KEGG   Pan paniscus (bonobo): 100970556
Entry
100970556         CDS       T02283                                 

Gene name
PTPN11
Definition
(RefSeq) protein tyrosine phosphatase, non-receptor type 11
  KO
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps04014  Ras signaling pathway
pps04072  Phospholipase D signaling pathway
pps04360  Axon guidance
pps04625  C-type lectin receptor signaling pathway
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04670  Leukocyte transendothelial migration
pps04722  Neurotrophin signaling pathway
pps04920  Adipocytokine signaling pathway
pps04931  Insulin resistance
pps05168  Herpes simplex virus 1 infection
pps05205  Proteoglycans in cancer
pps05211  Renal cell carcinoma
pps05220  Chronic myeloid leukemia
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100970556 (PTPN11)
   04630 JAK-STAT signaling pathway
    100970556 (PTPN11)
   04072 Phospholipase D signaling pathway
    100970556 (PTPN11)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100970556 (PTPN11)
   04650 Natural killer cell mediated cytotoxicity
    100970556 (PTPN11)
   04670 Leukocyte transendothelial migration
    100970556 (PTPN11)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    100970556 (PTPN11)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100970556 (PTPN11)
  09158 Development and regeneration
   04360 Axon guidance
    100970556 (PTPN11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    100970556 (PTPN11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100970556 (PTPN11)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    100970556 (PTPN11)
   05211 Renal cell carcinoma
    100970556 (PTPN11)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    100970556 (PTPN11)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    100970556 (PTPN11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:pps01009]
    100970556 (PTPN11)
Enzymes [BR:pps01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     100970556 (PTPN11)
Protein phosphatases and associated proteins [BR:pps01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    100970556 (PTPN11)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 100970556
NCBI-ProteinID: XP_014202822
Position
12
AA seq 512 aa
MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQ
SHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNP
MVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKL
LYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNS
KPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYG
VMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEE
VHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQR
SGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLP
PCTPTPPCAEMREDSARVYENVGLMQQQKSFR
NT seq 1539 nt   +upstreamnt  +downstreamnt
atggaacatcacgggcaattaaaagagaagaatggagatgtcattgagcttaaatatcct
ctgaactgtgcagatcctacctctgaaaggtggtttcatggacacctctctgggaaagaa
gcagagaaattattaactgaaaaaggaaaacatggtagttttcttgtacgagagagccag
agccaccctggagattttgttctttctgtgcgcactggtgatgacaaaggggagagcaat
gacggcaagtctaaagtgacccatgttatgattcgctgtcaggaactgaaatacgacgtt
ggtggaggagaacggtttgattctttgacagatcttgtggaacattataagaagaatcct
atggtggaaacattgggtacagtactacaactcaagcagccccttaacacgactcgtata
aatgctgctgaaatagaaagcagagttcgagaactaagcaaattagctgagaccacagat
aaagtcaaacaaggcttttgggaagaatttgagacactacaacaacaggagtgcaaactt
ctctacagccgaaaagagggtcaaaggcaagaaaacaaaaacaaaaatagatataaaaac
atcctgccctttgatcataccagggttgtcctacacgatggtgatcccaatgagcctgtt
tcagattacatcaatgcaaatatcatcatgcctgaatttgaaaccaagtgcaacaattca
aagcccaaaaagagttacattgccacacaaggctgcctgcaaaacacggtgaatgacttt
tggcggatggtgttccaagaaaactcccgagtgattgtcatgacaacgaaagaagtggag
agaggaaagagtaaatgtgtcaaatactggcctgatgagtatgctctaaaagaatatggc
gtcatgcgtgttaggaacgtcaaagaaagcgccgctcatgactatacgctaagagaactt
aaactttcaaaggttggacaagggaatacggagagaacggtctggcaataccactttcgg
acctggccggaccacggcgtacccagcgaccccgggggcgtgctggacttcctggaggag
gtgcaccataagcaggagagcatcatggatgcagggccggtcgtggtgcactgcagtgct
ggaattggccggacagggacgttcattgtgattgatattcttattgacatcatcagagag
aaaggtgttgactgcgatattgacgttcccaaaaccatccagatggtgcggtctcagagg
tcagggatggtccagacagaagcacagtaccgatttatctatatggcggtccagcattat
attgaaacactacagcgcaggattgaagaagagcagaaaagcaagaggaaagggcacgaa
tatacaaatattaagtattctctagcggaccagacgagtggagatcagagccccctcccg
ccttgtactccaacgccaccctgtgcagaaatgagagaagacagtgctagagtctatgaa
aacgtgggcctgatgcaacagcagaaaagtttcagatga

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