KEGG   Pan paniscus (bonobo): 100976294
Entry
100976294         CDS       T02283                                 

Gene name
CDK4
Definition
(RefSeq) cyclin dependent kinase 4
  KO
K02089  cyclin-dependent kinase 4 [EC:2.7.11.22]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01522  Endocrine resistance
pps04110  Cell cycle
pps04115  p53 signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04218  Cellular senescence
pps04530  Tight junction
pps04660  T cell receptor signaling pathway
pps04933  AGE-RAGE signaling pathway in diabetic complications
pps04934  Cushing syndrome
pps05160  Hepatitis C
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05169  Epstein-Barr virus infection
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05212  Pancreatic cancer
pps05214  Glioma
pps05218  Melanoma
pps05219  Bladder cancer
pps05220  Chronic myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    100976294 (CDK4)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    100976294 (CDK4)
   04115 p53 signaling pathway
    100976294 (CDK4)
   04218 Cellular senescence
    100976294 (CDK4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    100976294 (CDK4)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    100976294 (CDK4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100976294 (CDK4)
   05203 Viral carcinogenesis
    100976294 (CDK4)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100976294 (CDK4)
   05225 Hepatocellular carcinoma
    100976294 (CDK4)
   05214 Glioma
    100976294 (CDK4)
   05220 Chronic myeloid leukemia
    100976294 (CDK4)
   05218 Melanoma
    100976294 (CDK4)
   05219 Bladder cancer
    100976294 (CDK4)
   05224 Breast cancer
    100976294 (CDK4)
   05222 Small cell lung cancer
    100976294 (CDK4)
   05223 Non-small cell lung cancer
    100976294 (CDK4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100976294 (CDK4)
   05160 Hepatitis C
    100976294 (CDK4)
   05164 Influenza A
    100976294 (CDK4)
   05162 Measles
    100976294 (CDK4)
   05163 Human cytomegalovirus infection
    100976294 (CDK4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100976294 (CDK4)
   05169 Epstein-Barr virus infection
    100976294 (CDK4)
   05165 Human papillomavirus infection
    100976294 (CDK4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100976294 (CDK4)
   04934 Cushing syndrome
    100976294 (CDK4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100976294 (CDK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pps01001]
    100976294 (CDK4)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     100976294 (CDK4)
Protein kinases [BR:pps01001]
 Serine/threonine kinases: CMGC group
  CDK family
   100976294 (CDK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH Kdo ABC1 Haspin_kinase TCAD9 Kinase-like FTA2
Other DBs
NCBI-GeneID: 100976294
NCBI-ProteinID: XP_003824888
UniProt: A0A2R9BHC1
Position
12
AA seq 303 aa
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
NT seq 912 nt   +upstreamnt  +downstreamnt
atggctacctctcgatatgagccagtggctgaaattggtgtcggtgcctatgggacagtg
tacaaggcccgtgatccccacagtggccactttgtggccctcaagagtgtgagagtcccc
aatggaggaggaggtggaggaggccttcccatcagcacagttcgtgaggtggctttactg
aggcgactggaggcttttgagcatcccaatgttgtccggctgatggacgtctgtgccaca
tcccgaactgaccgggagatcaaggtaaccctggtgtttgagcatgtagaccaggaccta
aggacatatctggacaaggcacccccaccaggcttgccagccgaaaccatcaaggatctg
atgcgccagtttctaagaggcctagatttccttcatgccaattgcatcgttcaccgagat
ctgaagccagagaacattctggtgacaagtggtggaacagtcaagctggctgactttggc
ctggccagaatctacagctaccagatggcacttacacccgtggttgttacactctggtac
cgagctcccgaagttcttctgcagtccacatatgcaacacctgtggacatgtggagtgtt
ggctgtatctttgcagagatgtttcgtcgaaagcctctcttctgtggaaactcagaagcc
gaccagttgggcaaaatctttgacctgattgggctgcctccagaggatgactggcctcga
gatgtatccctgccccgtggagcctttccccccagagggccccgcccagtgcagtcggtg
gtacctgagatggaggagtcgggagcacagctgctgctggaaatgctgacttttaaccca
cacaagcgaatctctgcctttcgagctctgcagcactcttatctacataaggatgaaggt
aatccggagtga

KEGG   Pan paniscus (bonobo): 100981258
Entry
100981258         CDS       T02283                                 

Gene name
CDK6
Definition
(RefSeq) cyclin dependent kinase 6
  KO
K02091  cyclin-dependent kinase 6 [EC:2.7.11.22]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps04110  Cell cycle
pps04115  p53 signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04218  Cellular senescence
pps04934  Cushing syndrome
pps05160  Hepatitis C
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05169  Epstein-Barr virus infection
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05206  MicroRNAs in cancer
pps05212  Pancreatic cancer
pps05214  Glioma
pps05218  Melanoma
pps05220  Chronic myeloid leukemia
pps05222  Small cell lung cancer
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    100981258 (CDK6)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    100981258 (CDK6)
   04115 p53 signaling pathway
    100981258 (CDK6)
   04218 Cellular senescence
    100981258 (CDK6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100981258 (CDK6)
   05206 MicroRNAs in cancer
    100981258 (CDK6)
   05203 Viral carcinogenesis
    100981258 (CDK6)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    100981258 (CDK6)
   05225 Hepatocellular carcinoma
    100981258 (CDK6)
   05214 Glioma
    100981258 (CDK6)
   05220 Chronic myeloid leukemia
    100981258 (CDK6)
   05218 Melanoma
    100981258 (CDK6)
   05224 Breast cancer
    100981258 (CDK6)
   05222 Small cell lung cancer
    100981258 (CDK6)
   05223 Non-small cell lung cancer
    100981258 (CDK6)
  09172 Infectious disease: viral
   05160 Hepatitis C
    100981258 (CDK6)
   05164 Influenza A
    100981258 (CDK6)
   05162 Measles
    100981258 (CDK6)
   05163 Human cytomegalovirus infection
    100981258 (CDK6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100981258 (CDK6)
   05169 Epstein-Barr virus infection
    100981258 (CDK6)
   05165 Human papillomavirus infection
    100981258 (CDK6)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100981258 (CDK6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pps01001]
    100981258 (CDK6)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     100981258 (CDK6)
Protein kinases [BR:pps01001]
 Serine/threonine kinases: CMGC group
  CDK family
   100981258 (CDK6)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr APH ABC1 Kdo Haspin_kinase Kinase-like RIO1 FTA2 TCAD9
Other DBs
NCBI-GeneID: 100981258
NCBI-ProteinID: XP_003809779
Position
7
AA seq 326 aa
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
NT seq 981 nt   +upstreamnt  +downstreamnt
atggagaaggacggcctgtgccgcgctgaccagcagtacgaatgcgtggcggagatcggg
gagggcgcctatgggaaggtgttcaaggcccgcgacttgaagaacggaggccgtttcgtg
gcgttgaagcgcgtgcgggtgcagaccggcgaggagggcatgccgctctccaccatccgc
gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcaggttgttt
gatgtgtgcacagtgtcacgaacagacagagaaaccaaactaactttagtgtttgaacat
gtcgatcaagacttgaccacttacttggataaagttccagagcctggagtgcccactgaa
accataaaggatatgatgtttcagcttctccgaggtctggactttcttcattcacaccga
gtagtgcatcgcgatctaaaaccacagaacattctggtgaccagcagcggacaaataaaa
ctcgctgacttcggccttgcccgcatctatagtttccagatggctctaacctcagtggtc
gtcacgctgtggtacagagcacccgaagtcttgctccagtccagctacgccacccccgtg
gatctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt
ggaagttcagatgttgatcaactaggaaaaatcttggacgtaattggactcccaggagaa
gaagactggcctagagatgttgcccttcccaggcaggcttttcattcaaaatctgcccaa
ccaattgagaagtttgtaacagatattgatgaactaggcaaagacctacttctgaagtgt
ttgacatttaacccagccaaaagaatatctgcctacagtgccctgtctcacccatacttc
caggacctggaaaggtgcaaagaaaacctggattcccacctgccgcccagccagaacacc
tcggagctgaatacagcctga

KEGG   Pan paniscus (bonobo): 100981695
Entry
100981695         CDS       T02283                                 

Gene name
CDK2
Definition
(RefSeq) cyclin dependent kinase 2
  KO
K02206  cyclin-dependent kinase 2 [EC:2.7.11.22]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps04068  FoxO signaling pathway
pps04110  Cell cycle
pps04114  Oocyte meiosis
pps04115  p53 signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04218  Cellular senescence
pps04914  Progesterone-mediated oocyte maturation
pps04934  Cushing syndrome
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05169  Epstein-Barr virus infection
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05215  Prostate cancer
pps05222  Small cell lung cancer
pps05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    100981695 (CDK2)
   04151 PI3K-Akt signaling pathway
    100981695 (CDK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    100981695 (CDK2)
   04114 Oocyte meiosis
    100981695 (CDK2)
   04115 p53 signaling pathway
    100981695 (CDK2)
   04218 Cellular senescence
    100981695 (CDK2)
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    100981695 (CDK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100981695 (CDK2)
   05203 Viral carcinogenesis
    100981695 (CDK2)
  09162 Cancer: specific types
   05226 Gastric cancer
    100981695 (CDK2)
   05215 Prostate cancer
    100981695 (CDK2)
   05222 Small cell lung cancer
    100981695 (CDK2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100981695 (CDK2)
   05161 Hepatitis B
    100981695 (CDK2)
   05160 Hepatitis C
    100981695 (CDK2)
   05162 Measles
    100981695 (CDK2)
   05169 Epstein-Barr virus infection
    100981695 (CDK2)
   05165 Human papillomavirus infection
    100981695 (CDK2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100981695 (CDK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pps01001]
    100981695 (CDK2)
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:pps03032]
    100981695 (CDK2)
   03036 Chromosome and associated proteins [BR:pps03036]
    100981695 (CDK2)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     100981695 (CDK2)
Protein kinases [BR:pps01001]
 Serine/threonine kinases: CMGC group
  CDK family
   100981695 (CDK2)
DNA replication proteins [BR:pps03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    100981695 (CDK2)
Chromosome and associated proteins [BR:pps03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    100981695 (CDK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Haspin_kinase APH Kinase-like
Other DBs
NCBI-GeneID: 100981695
NCBI-ProteinID: XP_003824995
UniProt: A0A2R9B4E4
Position
12
AA seq 298 aa
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
NT seq 897 nt   +upstreamnt  +downstreamnt
atggagaacttccaaaaggtggaaaagatcggagagggcacgtacggagttgtgtacaaa
gccagaaacaagttgacgggagaagtggtggcgcttaagaaaatccgcctggacactgag
actgagggtgtgcccagtactgccatccgagagatctctctgcttaaggagcttaaccat
cctaatattgtcaagctgctggatgtcattcacacagaaaataaactctacctggttttt
gaatttctgcaccaagatctcaagaaattcatggatgcctctgctctcactggcattcct
cttcccctcatcaagagctatctgttccagctgctccagggcctagctttctgccattct
catcgggtcctccaccgagaccttaaacctcagaatctgcttattaacacagagggggcc
atcaagctagcagactttggactagccagagcttttggagtccctgttcgtacttacacc
catgaggtggtgaccctgtggtaccgagctcctgaaatcctcctgggctgcaaatattat
tccacagctgtggacatctggagcctgggctgcatctttgctgagatggtgactcgccgg
gccctattccctggagattctgagattgaccagctcttccggatctttcggactctgggg
accccagatgaggtggtgtggccaggagttacttctatgcctgattacaagccaagtttc
cccaagtgggcccggcaagattttagtaaagttgtacctcccctggatgaagatggacgg
agcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcagcc
ctggctcaccctttcttccaggatgtgaccaagccagtaccccatcttcgactctga

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