KEGG   Pan paniscus (bonobo): 100978497
Entry
100978497         CDS       T02283                                 
Symbol
CASP8
Name
(RefSeq) caspase-8 isoform X1
  KO
K04398  caspase 8 [EC:3.4.22.61]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01524  Platinum drug resistance
pps04115  p53 signaling pathway
pps04210  Apoptosis
pps04215  Apoptosis - multiple species
pps04217  Necroptosis
pps04620  Toll-like receptor signaling pathway
pps04621  NOD-like receptor signaling pathway
pps04622  RIG-I-like receptor signaling pathway
pps04623  Cytosolic DNA-sensing pathway
pps04625  C-type lectin receptor signaling pathway
pps04657  IL-17 signaling pathway
pps04668  TNF signaling pathway
pps04932  Non-alcoholic fatty liver disease
pps04936  Alcoholic liver disease
pps05010  Alzheimer disease
pps05016  Huntington disease
pps05022  Pathways of neurodegeneration - multiple diseases
pps05132  Salmonella infection
pps05134  Legionellosis
pps05142  Chagas disease
pps05145  Toxoplasmosis
pps05152  Tuberculosis
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05162  Measles
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05168  Herpes simplex virus 1 infection
pps05169  Epstein-Barr virus infection
pps05170  Human immunodeficiency virus 1 infection
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05416  Viral myocarditis
pps05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    100978497 (CASP8)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    100978497 (CASP8)
   04215 Apoptosis - multiple species
    100978497 (CASP8)
   04217 Necroptosis
    100978497 (CASP8)
   04115 p53 signaling pathway
    100978497 (CASP8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100978497 (CASP8)
   04621 NOD-like receptor signaling pathway
    100978497 (CASP8)
   04622 RIG-I-like receptor signaling pathway
    100978497 (CASP8)
   04623 Cytosolic DNA-sensing pathway
    100978497 (CASP8)
   04625 C-type lectin receptor signaling pathway
    100978497 (CASP8)
   04657 IL-17 signaling pathway
    100978497 (CASP8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100978497 (CASP8)
   05203 Viral carcinogenesis
    100978497 (CASP8)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100978497 (CASP8)
   05161 Hepatitis B
    100978497 (CASP8)
   05160 Hepatitis C
    100978497 (CASP8)
   05164 Influenza A
    100978497 (CASP8)
   05162 Measles
    100978497 (CASP8)
   05168 Herpes simplex virus 1 infection
    100978497 (CASP8)
   05163 Human cytomegalovirus infection
    100978497 (CASP8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100978497 (CASP8)
   05169 Epstein-Barr virus infection
    100978497 (CASP8)
   05165 Human papillomavirus infection
    100978497 (CASP8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100978497 (CASP8)
   05134 Legionellosis
    100978497 (CASP8)
   05152 Tuberculosis
    100978497 (CASP8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100978497 (CASP8)
   05142 Chagas disease
    100978497 (CASP8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100978497 (CASP8)
   05016 Huntington disease
    100978497 (CASP8)
   05022 Pathways of neurodegeneration - multiple diseases
    100978497 (CASP8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100978497 (CASP8)
   05416 Viral myocarditis
    100978497 (CASP8)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100978497 (CASP8)
   04932 Non-alcoholic fatty liver disease
    100978497 (CASP8)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    100978497 (CASP8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:pps01002]
    100978497 (CASP8)
Enzymes [BR:pps01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     100978497 (CASP8)
Peptidases and inhibitors [BR:pps01002]
 Cysteine peptidases
  Family C14: caspase family
   100978497 (CASP8)
SSDB
Motif
Pfam: Peptidase_C14 DED PYRIN
Other DBs
NCBI-GeneID: 100978497
NCBI-ProteinID: XP_003820792
Ensembl: ENSPPAG00000030711
Position
13:103859979..103910906
AA seq 538 aa
MEGGRRDRVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKM
DFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSF
LKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFK
FLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINRSLLKIINDYEEF
SKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINN
HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVQQIYEILKIYQL
MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQ
GDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWY
IQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
NT seq 1617 nt   +upstreamnt  +downstreamnt
atggagggaggcagaagagacagggtggttattgaaagtaaaagaaacttcttcctggga
gcctttcccacccccttccctgctgagcacgtggagttaggcaggttaggggactcggag
actgcgatggtgccaggaaagggtggagcggattatattctcctgccttttaaaaagatg
gacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcctcc
ctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggatgcc
ttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtccttc
ctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaacact
agaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcctac
agggtcatgctgtatcagatttcagaagaagtgagcagatcagaattgaggtcttttaag
tttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctggat
attttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctgaaa
agagtctgtgcccaaatcaacaggagcctgctgaagataatcaacgactatgaagaattc
agcaaagagagaagcagcagccttgaaggaagtcctgatgaattttcaaatggggaggag
ttgtgtggggtaatgacaatctcggactctccaagagaacaggatagtgaatcacagact
ttggacaaagtttaccaaatgaaaagcaaacctcggggatactgtctgatcatcaacaat
cacaattttgcaaaagcacgggagaaagtgcccaaacttcacagtattagggacaggaat
ggaacacacttggatgcaggggctttgaccacgacctttgaagagcttcattttgagatc
aagccccacgatgactgcacggtacagcaaatctatgagattttgaaaatctaccaactc
atggaccacagtaacatggactgcttcatctgctgtatcctctcccatggagacaagggc
atcatctacggcactgatggacaggaggcccccatctatgagctgacatctcagttcact
ggtttgaagtgcccttcccttgctggaaaacccaaagtgttttttattcaggcttgtcag
ggggataactaccagaaaggtatacctgttgagactgattcagaggagcaaccctattta
gaaatggatttatcatcacctcaaacgagatatatcccggatgaggctgactttctgctg
gggatggccactgtgaataactgtgtttcctaccgaaaccctgcagagggaacctggtac
atccagtcactttgccagagcctgagagagcgatgtcctcgaggcgatgatattctcacc
atcctgactgaagtgaactatgaagtaagcaacaaggatgacaagaaaaacatggggaaa
cagatgcctcagcctactttcacattaagaaaaaaacttgtcttcccttctgattga

  All links  
Gene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (13)   
   RefSeq(pep) (13)   
DNA sequence (15)   
   RefSeq(nuc) (15)   
Protein domain (3)   
   Pfam (3)   
All databases (35)   

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