KEGG   Pan paniscus (bonobo): 100988422
Entry
100988422         CDS       T02283                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps04010  MAPK signaling pathway
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04015  Rap1 signaling pathway
pps04022  cGMP-PKG signaling pathway
pps04024  cAMP signaling pathway
pps04062  Chemokine signaling pathway
pps04066  HIF-1 signaling pathway
pps04068  FoxO signaling pathway
pps04071  Sphingolipid signaling pathway
pps04072  Phospholipase D signaling pathway
pps04114  Oocyte meiosis
pps04140  Autophagy - animal
pps04148  Efferocytosis
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04210  Apoptosis
pps04218  Cellular senescence
pps04270  Vascular smooth muscle contraction
pps04370  VEGF signaling pathway
pps04371  Apelin signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04540  Gap junction
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04613  Neutrophil extracellular trap formation
pps04620  Toll-like receptor signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04666  Fc gamma R-mediated phagocytosis
pps04668  TNF signaling pathway
pps04720  Long-term potentiation
pps04722  Neurotrophin signaling pathway
pps04725  Cholinergic synapse
pps04726  Serotonergic synapse
pps04730  Long-term depression
pps04810  Regulation of actin cytoskeleton
pps04910  Insulin signaling pathway
pps04912  GnRH signaling pathway
pps04914  Progesterone-mediated oocyte maturation
pps04915  Estrogen signaling pathway
pps04916  Melanogenesis
pps04917  Prolactin signaling pathway
pps04919  Thyroid hormone signaling pathway
pps04921  Oxytocin signaling pathway
pps04926  Relaxin signaling pathway
pps04928  Parathyroid hormone synthesis, secretion and action
pps04929  GnRH secretion
pps04934  Cushing syndrome
pps04935  Growth hormone synthesis, secretion and action
pps05010  Alzheimer disease
pps05022  Pathways of neurodegeneration - multiple diseases
pps05034  Alcoholism
pps05132  Salmonella infection
pps05135  Yersinia infection
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05163  Human cytomegalovirus infection
pps05164  Influenza A
pps05165  Human papillomavirus infection
pps05166  Human T-cell leukemia virus 1 infection
pps05167  Kaposi sarcoma-associated herpesvirus infection
pps05170  Human immunodeficiency virus 1 infection
pps05200  Pathways in cancer
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05207  Chemical carcinogenesis - receptor activation
pps05208  Chemical carcinogenesis - reactive oxygen species
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05212  Pancreatic cancer
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05216  Thyroid cancer
pps05218  Melanoma
pps05219  Bladder cancer
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05230  Central carbon metabolism in cancer
pps05231  Choline metabolism in cancer
pps05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100988422 (MAP2K1)
   04012 ErbB signaling pathway
    100988422 (MAP2K1)
   04014 Ras signaling pathway
    100988422 (MAP2K1)
   04015 Rap1 signaling pathway
    100988422 (MAP2K1)
   04370 VEGF signaling pathway
    100988422 (MAP2K1)
   04371 Apelin signaling pathway
    100988422 (MAP2K1)
   04668 TNF signaling pathway
    100988422 (MAP2K1)
   04066 HIF-1 signaling pathway
    100988422 (MAP2K1)
   04068 FoxO signaling pathway
    100988422 (MAP2K1)
   04072 Phospholipase D signaling pathway
    100988422 (MAP2K1)
   04071 Sphingolipid signaling pathway
    100988422 (MAP2K1)
   04024 cAMP signaling pathway
    100988422 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    100988422 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    100988422 (MAP2K1)
   04150 mTOR signaling pathway
    100988422 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100988422 (MAP2K1)
   04148 Efferocytosis
    100988422 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    100988422 (MAP2K1)
   04210 Apoptosis
    100988422 (MAP2K1)
   04218 Cellular senescence
    100988422 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100988422 (MAP2K1)
   04540 Gap junction
    100988422 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100988422 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100988422 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100988422 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    100988422 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    100988422 (MAP2K1)
   04660 T cell receptor signaling pathway
    100988422 (MAP2K1)
   04662 B cell receptor signaling pathway
    100988422 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    100988422 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    100988422 (MAP2K1)
   04062 Chemokine signaling pathway
    100988422 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100988422 (MAP2K1)
   04929 GnRH secretion
    100988422 (MAP2K1)
   04912 GnRH signaling pathway
    100988422 (MAP2K1)
   04915 Estrogen signaling pathway
    100988422 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    100988422 (MAP2K1)
   04917 Prolactin signaling pathway
    100988422 (MAP2K1)
   04921 Oxytocin signaling pathway
    100988422 (MAP2K1)
   04926 Relaxin signaling pathway
    100988422 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    100988422 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    100988422 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    100988422 (MAP2K1)
   04916 Melanogenesis
    100988422 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100988422 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    100988422 (MAP2K1)
   04726 Serotonergic synapse
    100988422 (MAP2K1)
   04720 Long-term potentiation
    100988422 (MAP2K1)
   04730 Long-term depression
    100988422 (MAP2K1)
   04722 Neurotrophin signaling pathway
    100988422 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100988422 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100988422 (MAP2K1)
   05206 MicroRNAs in cancer
    100988422 (MAP2K1)
   05205 Proteoglycans in cancer
    100988422 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    100988422 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100988422 (MAP2K1)
   05230 Central carbon metabolism in cancer
    100988422 (MAP2K1)
   05231 Choline metabolism in cancer
    100988422 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100988422 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100988422 (MAP2K1)
   05212 Pancreatic cancer
    100988422 (MAP2K1)
   05225 Hepatocellular carcinoma
    100988422 (MAP2K1)
   05226 Gastric cancer
    100988422 (MAP2K1)
   05214 Glioma
    100988422 (MAP2K1)
   05216 Thyroid cancer
    100988422 (MAP2K1)
   05221 Acute myeloid leukemia
    100988422 (MAP2K1)
   05220 Chronic myeloid leukemia
    100988422 (MAP2K1)
   05218 Melanoma
    100988422 (MAP2K1)
   05211 Renal cell carcinoma
    100988422 (MAP2K1)
   05219 Bladder cancer
    100988422 (MAP2K1)
   05215 Prostate cancer
    100988422 (MAP2K1)
   05213 Endometrial cancer
    100988422 (MAP2K1)
   05224 Breast cancer
    100988422 (MAP2K1)
   05223 Non-small cell lung cancer
    100988422 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100988422 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    100988422 (MAP2K1)
   05161 Hepatitis B
    100988422 (MAP2K1)
   05160 Hepatitis C
    100988422 (MAP2K1)
   05164 Influenza A
    100988422 (MAP2K1)
   05163 Human cytomegalovirus infection
    100988422 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100988422 (MAP2K1)
   05165 Human papillomavirus infection
    100988422 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100988422 (MAP2K1)
   05135 Yersinia infection
    100988422 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100988422 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    100988422 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    100988422 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100988422 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100988422 (MAP2K1)
   01522 Endocrine resistance
    100988422 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pps01001]
    100988422 (MAP2K1)
Enzymes [BR:pps01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     100988422 (MAP2K1)
Protein kinases [BR:pps01001]
 Serine/threonine kinases: STE group
  STE7 family
   100988422 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 100988422
NCBI-ProteinID: XP_003828040
Ensembl: ENSPPAG00000028577
UniProt: A0A2R9A4U3
Position
15:45337117..45438826
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactgtctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggaa
ggagatgcggctgagaccccacccaggccaaggacccccgggaggccccttagctcatac
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (90)   
   KEGG PATHWAY (90)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (7)   
   Pfam (7)   
All databases (110)   

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