KEGG   Pan paniscus (bonobo): 100993451
Entry
100993451         CDS       T02283                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
pps  Pan paniscus (bonobo)
Pathway
pps01521  EGFR tyrosine kinase inhibitor resistance
pps01522  Endocrine resistance
pps04010  MAPK signaling pathway
pps04012  ErbB signaling pathway
pps04014  Ras signaling pathway
pps04062  Chemokine signaling pathway
pps04068  FoxO signaling pathway
pps04072  Phospholipase D signaling pathway
pps04150  mTOR signaling pathway
pps04151  PI3K-Akt signaling pathway
pps04380  Osteoclast differentiation
pps04510  Focal adhesion
pps04540  Gap junction
pps04550  Signaling pathways regulating pluripotency of stem cells
pps04630  JAK-STAT signaling pathway
pps04650  Natural killer cell mediated cytotoxicity
pps04660  T cell receptor signaling pathway
pps04662  B cell receptor signaling pathway
pps04664  Fc epsilon RI signaling pathway
pps04714  Thermogenesis
pps04722  Neurotrophin signaling pathway
pps04910  Insulin signaling pathway
pps04912  GnRH signaling pathway
pps04915  Estrogen signaling pathway
pps04917  Prolactin signaling pathway
pps04926  Relaxin signaling pathway
pps04935  Growth hormone synthesis, secretion and action
pps05034  Alcoholism
pps05160  Hepatitis C
pps05161  Hepatitis B
pps05163  Human cytomegalovirus infection
pps05165  Human papillomavirus infection
pps05200  Pathways in cancer
pps05203  Viral carcinogenesis
pps05205  Proteoglycans in cancer
pps05206  MicroRNAs in cancer
pps05210  Colorectal cancer
pps05211  Renal cell carcinoma
pps05213  Endometrial cancer
pps05214  Glioma
pps05215  Prostate cancer
pps05220  Chronic myeloid leukemia
pps05221  Acute myeloid leukemia
pps05223  Non-small cell lung cancer
pps05224  Breast cancer
pps05225  Hepatocellular carcinoma
pps05226  Gastric cancer
pps05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:pps00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100993451 (GRB2)
   04012 ErbB signaling pathway
    100993451 (GRB2)
   04014 Ras signaling pathway
    100993451 (GRB2)
   04630 JAK-STAT signaling pathway
    100993451 (GRB2)
   04068 FoxO signaling pathway
    100993451 (GRB2)
   04072 Phospholipase D signaling pathway
    100993451 (GRB2)
   04151 PI3K-Akt signaling pathway
    100993451 (GRB2)
   04150 mTOR signaling pathway
    100993451 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100993451 (GRB2)
   04540 Gap junction
    100993451 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100993451 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100993451 (GRB2)
   04660 T cell receptor signaling pathway
    100993451 (GRB2)
   04662 B cell receptor signaling pathway
    100993451 (GRB2)
   04664 Fc epsilon RI signaling pathway
    100993451 (GRB2)
   04062 Chemokine signaling pathway
    100993451 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100993451 (GRB2)
   04912 GnRH signaling pathway
    100993451 (GRB2)
   04915 Estrogen signaling pathway
    100993451 (GRB2)
   04917 Prolactin signaling pathway
    100993451 (GRB2)
   04926 Relaxin signaling pathway
    100993451 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    100993451 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100993451 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100993451 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    100993451 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100993451 (GRB2)
   05206 MicroRNAs in cancer
    100993451 (GRB2)
   05205 Proteoglycans in cancer
    100993451 (GRB2)
   05203 Viral carcinogenesis
    100993451 (GRB2)
   05231 Choline metabolism in cancer
    100993451 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100993451 (GRB2)
   05225 Hepatocellular carcinoma
    100993451 (GRB2)
   05226 Gastric cancer
    100993451 (GRB2)
   05214 Glioma
    100993451 (GRB2)
   05221 Acute myeloid leukemia
    100993451 (GRB2)
   05220 Chronic myeloid leukemia
    100993451 (GRB2)
   05211 Renal cell carcinoma
    100993451 (GRB2)
   05215 Prostate cancer
    100993451 (GRB2)
   05213 Endometrial cancer
    100993451 (GRB2)
   05224 Breast cancer
    100993451 (GRB2)
   05223 Non-small cell lung cancer
    100993451 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100993451 (GRB2)
   05160 Hepatitis C
    100993451 (GRB2)
   05163 Human cytomegalovirus infection
    100993451 (GRB2)
   05165 Human papillomavirus infection
    100993451 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    100993451 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100993451 (GRB2)
   01522 Endocrine resistance
    100993451 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pps04131]
    100993451 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:pps04990]
    100993451 (GRB2)
Membrane trafficking [BR:pps04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    100993451 (GRB2)
Domain-containing proteins not elsewhere classified [BR:pps04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   100993451 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 100993451
NCBI-ProteinID: XP_003813338
UniProt: A0A2R9A3I9
Position
17
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaacgaagaatgtgatcagaactggtacaaggcagag
cttaatggaaaagacggcttcattcccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttcttatccgagagagtgagagcgctcctggggacttctccctctctgtcaag
tttggaaacgatgtgcagcacttcaaggtgctccgagatggagccgggaagtacttcctc
tgggtggtgaagttcaattctttgaatgagctggtggattatcacagatctacatctgtc
tccagaaaccagcagatattcctgcgggacatagaacaggtgccacagcagccgacatac
gtccaggccctctttgactttgatccccaggaggatggagagctgggcttccgccgggga
gattttatccatgtcatggataactcagaccccaactggtggaaaggagcttgccacggg
cagaccggcatgtttccccgcaattatgtcacccccgtgaaccggaacgtctaa

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