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Database: PROSITE
Entry: PS00136
LinkDB: PS00136
Original site: PS00136 
ID   SUBTILASE_ASP; PATTERN.
AC   PS00136;
DT   01-APR-1990 CREATED; 01-DEC-2004 DATA UPDATE; 13-NOV-2019 INFO UPDATE.
DE   Serine proteases, subtilase family, aspartic acid active site.
PA   [STAIV]-{ERDL}-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-[DNH].
NR   /RELEASE=2019_10,561356;
NR   /TOTAL=354(354); /POSITIVE=172(172); /UNKNOWN=0(0); /FALSE_POS=182(182);
NR   /FALSE_NEG=0; /PARTIAL=6;
CC   /TAXO-RANGE=A?EP?; /MAX-REPEAT=1;
CC   /SITE=5,active_site;
CC   /VERSION=1;
DR   P09230    , AEP_YARLI  , T; P91863    , AEX5_CAEEL , T;
DR   P29118    , ALP_ACRCH  , T; P83610    , ALP_FUSCU  , T;
DR   Q03420    , ALP_HYPAT  , T; Q68GV9    , ALP_LECPS  , T;
DR   O31788    , APRX_BACSU , T; P08594    , AQL1_THEAQ , T;
DR   R4IR27    , ASES_SARSR , T; P31339    , ASPA_AERSA , T;
DR   P51559    , BLI4_CAEEL , T; A0A044RE18, BLI_ONCVO  , T;
DR   P42779    , BPRV_DICNO , T; P42780    , BPRX_DICNO , T;
DR   P58099    , C5AP_STRP1 , T; P0DD34    , C5AP_STRP3 , T;
DR   Q5X9R0    , C5AP_STRP6 , T; Q8NZ80    , C5AP_STRP8 , T;
DR   P0DD35    , C5AP_STRPQ , T; P15926    , C5AP_STRPY , T;
DR   P29138    , CUDP_METAN , T; P27693    , ELYA_BACAO , T;
DR   P41362    , ELYA_BACCS , T; P41363    , ELYA_BACHD , T;
DR   P20724    , ELYA_BACYA , T; P30199    , EPIP_STAEP , T;
DR   P23314    , EXPR_XANCP , T; O17798    , FKPC1_CAEEL, T;
DR   Q93LQ6    , FLS_FERPE  , T; P26016    , FUR11_DROME, T;
DR   P30430    , FUR1C_DROME, T; P30432    , FUR2_DROME , T;
DR   P29119    , FURI1_XENLA, T; Q28193    , FURIN_BOVIN, T;
DR   P09958    , FURIN_HUMAN, T; P23188    , FURIN_MOUSE, T;
DR   P23377    , FURIN_RAT  , T; P11018    , ISP1_BACSU , T;
DR   P40903    , ISP6_SCHPO , T; P29140    , ISP_BACCS  , T;
DR   P29139    , ISP_PAEPO  , T; P09231    , KEX1A_KLULA, T;
DR   P13134    , KEX2_YEAST , T; Q09175    , KRP1_SCHPO , T;
DR   O05458    , MYCP2_MYCTU, T; I6YC58    , MYCP4_MYCTU, T;
DR   O53945    , MYCP5_MYCTU, T; Q9GLR1    , NEC1_BOVIN , T;
DR   P29120    , NEC1_HUMAN , T; P63239    , NEC1_MOUSE , T;
DR   P63240    , NEC1_MUSCO , T; P28840    , NEC1_RAT   , T;
DR   Q9GLR0    , NEC2_BOVIN , T; G5ECN9    , NEC2_CAEEL , T;
DR   P16519    , NEC2_HUMAN , T; P21661    , NEC2_MOUSE , T;
DR   Q03333    , NEC2_PIG   , T; Q5REC2    , NEC2_PONAB , T;
DR   P28841    , NEC2_RAT   , T; P29146    , NECA_HYDVU , T;
DR   P29145    , NECB_HYDVU , T; Q07596    , NISP_LACLL , T;
DR   P83433    , NVSP_ALIVI , T; A1CIA7    , ORYZ_ASPCL , T;
DR   B0Y708    , ORYZ_ASPFC , T; B8N106    , ORYZ_ASPFN , T;
DR   P28296    , ORYZ_ASPFU , T; P12547    , ORYZ_ASPOR , T;
DR   Q00208    , ORYZ_EMENI , T; A1CWF3    , ORYZ_NEOFI , T;
DR   P16271    , P1P_LACLC  , T; P15293    , P2P_LACLC  , T;
DR   Q02470    , P2P_LACPA  , T; P15292    , P3P_LACLS  , T;
DR   Q6UW60    , PCSK4_HUMAN, T; P29121    , PCSK4_MOUSE, T;
DR   Q78EH2    , PCSK4_RAT  , T; Q92824    , PCSK5_HUMAN, T;
DR   Q04592    , PCSK5_MOUSE, T; P41413    , PCSK5_RAT  , T;
DR   P29122    , PCSK6_HUMAN, T; Q63415    , PCSK6_RAT  , T;
DR   P81719    , PIIS_ACHLY , T; P72186    , PLS_PYRFU  , T;
DR   Q59149    , PRCA_NOSS1 , T; P23916    , PRCA_TRIV2 , T;
DR   P16588    , PROA_VIBAL , T; P09232    , PRTB_YEAST , T;
DR   P06873    , PRTK_PARAQ , T; Q99405    , PRTM_BACSK , T;
DR   P23653    , PRTR_PARAQ , T; P20015    , PRTT_PARAQ , T;
DR   Q9UTS0    , PSP3_SCHPO , T; Q32ZM1    , RM201_RHOMI, T;
DR   P25381    , RRT12_YEAST, T; Q84WS0    , SBT11_ARATH, T;
DR   Q9LVJ1    , SBT14_ARATH, T; Q9FHA4    , SBT19_ARATH, T;
DR   Q9SA75    , SBT21_ARATH, T; Q9SUN6    , SBT22_ARATH, T;
DR   Q9FI12    , SBT23_ARATH, T; F4HYR6    , SBT24_ARATH, T;
DR   O64481    , SBT25_ARATH, T; Q9SZV5    , SBT26_ARATH, T;
DR   Q8GWX9    , SBT3G_ARATH, T; Q9LLL8    , SBT4E_ARATH, T;
DR   P80146    , SEPR_THESR , T; Q9Y778    , SMP1_MAGPO , T;
DR   G1X8P8    , SPAZ_ARTOA , T; G3FNQ9    , SPAZ_ARTOL , T;
DR   Q8SQJ3    , SPL1_ENCCU , T; D4AQG0    , SUB10_ARTBC, T;
DR   D4DIS6    , SUB10_TRIVH, T; L8G6I7    , SUB1_PSED2 , T;
DR   C5P6D1    , SUB2A_COCP7, T; C5P906    , SUB2B_COCP7, T;
DR   C5NZ70    , SUB2C_COCP7, T; D4AZ75    , SUB2_ARTBC , T;
DR   Q64K35    , SUB2_ARTBE , T; E4UZP9    , SUB2_ARTGP , T;
DR   C5G168    , SUB2_ARTOC , T; Q8J0D8    , SUB2_ARTOT , T;
DR   L8FSM5    , SUB2_PSED2 , T; B6VA85    , SUB2_TRIEQ , T;
DR   Q69F57    , SUB2_TRIRU , T; B8XGQ5    , SUB2_TRITO , T;
DR   Q5VJ76    , SUB2_TRIVC , T; D4DLI5    , SUB2_TRIVH , T;
DR   L8GD75    , SUB3_PSED2 , T; C5NZT2    , SUB4B_COCP7, T;
DR   D4B194    , SUB5_ARTBC , T; Q64K32    , SUB5_ARTBE , T;
DR   E4V2L6    , SUB5_ARTGP , T; C5G1D1    , SUB5_ARTOC , T;
DR   B6VA87    , SUB5_TRIEQ , T; Q69F34    , SUB5_TRIRU , T;
DR   B8XGQ8    , SUB5_TRITO , T; Q5VJ73    , SUB5_TRIVC , T;
DR   D4D0F5    , SUB5_TRIVH , T; D4ALV9    , SUB6_ARTBC , T;
DR   Q64K31    , SUB6_ARTBE , T; E4V4J8    , SUB6_ARTGP , T;
DR   C5FQI3    , SUB6_ARTOC , T; A1XIH0    , SUB6_TRIEQ , T;
DR   Q9UW97    , SUB6_TRIRU , T; A1XIH1    , SUB6_TRISD , T;
DR   Q8J077    , SUB6_TRISH , T; Q3ZEJ8    , SUB6_TRITO , T;
DR   Q5VJ72    , SUB6_TRIVC , T; D4D5H3    , SUB6_TRIVH , T;
DR   C5PGK9    , SUB7A_COCP7, T; C5NZ69    , SUB7C_COCP7, T;
DR   C5P9H3    , SUB7D_COCP7, T; P29599    , SUBB_BACLE , T;
DR   P00780    , SUBC_BACLI , T; P00781    , SUBD_BACLI , T;
DR   P16396    , SUBE_BACSU , T; P35835    , SUBN_BACNA , T;
DR   P29600    , SUBS_BACLE , T; P00782    , SUBT_BACAM , T;
DR   P07518    , SUBT_BACPU , T; P28842    , SUBT_BACS9 , T;
DR   P00783    , SUBT_BACSA , T; P04189    , SUBT_BACSU , T;
DR   P29142    , SUBT_GEOSE , T; P29141    , SUBV_BACSU , T;
DR   Q45670    , THES_BACSJ , T; P04072    , THET_THEVU , T;
DR   Q5JIZ5    , TKSP_THEKO , T; P58502    , TKSU_THEKO , T;
DR   P42781    , XPR6_YARLI , T; P25036    , YSP3_YEAST , T;
DR   P85157    , ASE2_ACRSP , P; P80406    , CUDP_METCM , P;
DR   P83454    , NCP3_COPCM , P; P28308    , PRTE_HALME , P;
DR   Q10721    , SP01_SCEBO , P; P13858    , THEM_MALCI , P;
DR   O29165    , ACDA1_ARCFU, F; O00906    , AGLU_TETPY , F;
DR   Q7G9P4    , ALDO3_ARATH, F; P56095    , AP1_KLULA  , F;
DR   Q7NRT5    , ARGC_CHRVO , F; Q8RSQ2    , BAH_RHOER  , F;
DR   Q7MYE3    , BTUB_PHOLL , F; Q7V3N8    , CBID_PROMP , F;
DR   O13356    , CHS1_CRYNH , F; Q5HEB2    , CLS2_STAAC , F;
DR   Q6GEY7    , CLS2_STAAR , F; P63800    , CLS_STAAM  , F;
DR   P63801    , CLS_STAAN  , F; Q6G7M2    , CLS_STAAS  , F;
DR   P63802    , CLS_STAAW  , F; Q9RYR8    , COBT_DEIRA , F;
DR   A7LFZ6    , DCL4_ORYSJ , F; Q9Y485    , DMXL1_HUMAN, F;
DR   Q6PNC0    , DMXL1_MOUSE, F; P57028    , DNAG_NEIMA , F;
DR   P57029    , DNAG_NEIMB , F; B1VUC2    , DNLJ1_STRGG, F;
DR   A7HJG6    , DNLJ_FERNB , F; P35406    , DRD1_CARAU , F;
DR   Q54NV1    , EXOC1_DICDI, F; P26487    , FIXJ_AZOC5 , F;
DR   Q89AZ7    , FLII_BUCBP , F; Q74GW4    , FMT_GEOSL  , F;
DR   Q6F8N7    , FOLD2_ACIAD, F; A3M846    , FOLD_ACIBT , F;
DR   Q8RAD0    , FOLD_CALS4 , F; Q8EV80    , FOLD_MYCPE , F;
DR   Q4FTX6    , FOLD_PSYA2 , F; Q1QD30    , FOLD_PSYCK , F;
DR   A1AXA0    , FOLD_RUTMC , F; Q6A7Y1    , GLUQ_CUTAK , F;
DR   Q6AAU3    , GLYA_CUTAK , F; A0R2V7    , GLYA_MYCS2 , F;
DR   Q6L1Q1    , GUAAB_PICTO, F; Q2UFN0    , GUAA_ASPOR , F;
DR   Q2RWE2    , HEM1_RHORT , F; P60596    , HIS5_ECOL6 , F;
DR   P60595    , HIS5_ECOLI , F; Q323I9    , HIS5_SHIBS , F;
DR   Q32EF2    , HIS5_SHIDS , F; Q83KJ5    , HIS5_SHIFL , F;
DR   Q3Z0G2    , HIS5_SHISS , F; Q9REB3    , HLYE_ECO57 , F;
DR   P77335    , HLYE_ECOLI , F; A1L1N5    , HN1BA_DANRE, F;
DR   Q8UW00    , HN1BB_DANRE, F; B2T2S2    , HOA_PARPJ  , F;
DR   Q99160    , HOY1_YARLI , F; A6TV07    , KATG2_ALKMQ, F;
DR   B4R8U3    , KATG_PHEZH , F; Q21DT6    , KATG_SACD2 , F;
DR   Q1M651    , KUP3_RHIL3 , F; Q9UIQ6    , LCAP_HUMAN , F;
DR   P22971    , LEC2_CYTSE , F; Q2YL58    , LEU3_BRUA2 , F;
DR   Q579B1    , LEU3_BRUAB , F; Q8YCX4    , LEU3_BRUME , F;
DR   Q8FVF3    , LEU3_BRUSU , F; Q17X64    , LPXK_HELAH , F;
DR   Q1CUH3    , LPXK_HELPH , F; Q9ZMB1    , LPXK_HELPJ , F;
DR   O25095    , LPXK_HELPY , F; A5PJJ5    , LRC14_BOVIN, F;
DR   Q15048    , LRC14_HUMAN, F; Q8VC16    , LRC14_MOUSE, F;
DR   Q569B5    , LRC14_RAT  , F; A8WHP9    , LRRC3_DANRE, F;
DR   Q9TMC8    , MATK_GAGLU , F; A6MMS5    , MATK_ILLOL , F;
DR   Q8LFA9    , METL2_ARATH, F; Q4ZZR8    , METN1_PSEU2, F;
DR   A5D9D4    , MSTO1_BOVIN, F; Q9BUK6    , MSTO1_HUMAN, F;
DR   Q4R681    , MSTO1_MACFA, F; Q2YDW2    , MSTO1_MOUSE, F;
DR   Q5RF82    , MSTO1_PONPY, F; P12845    , MYO2_CAEEL , F;
DR   Q9M0N8    , MZT1B_ARATH, F; Q8EFF2    , NADE_SHEON , F;
DR   Q7G765    , NADO2_ORYSJ, F; P18446    , NCAP_CVM1  , F;
DR   Q9PY96    , NCAP_CVM2  , F; P18447    , NCAP_CVM3  , F;
DR   P03416    , NCAP_CVMA5 , F; Q83360    , NCAP_CVMDV , F;
DR   P03417    , NCAP_CVMJH , F; P18448    , NCAP_CVMS  , F;
DR   P59713    , NCAP_CVPV  , F; Q9WCD0    , NCAP_CVRNJ , F;
DR   Q02915    , NCAP_CVRSD , F; P85527    , NEMS_APIME , F;
DR   Q8IH00    , NOL6_DROME , F; B4IBY3    , NOL6_DROSE , F;
DR   B4QX57    , NOL6_DROSI , F; B4PR18    , NOL6_DROYA , F;
DR   A0JNE3    , NR2C1_BOVIN, F; P13056    , NR2C1_HUMAN, F;
DR   Q95K90    , NR2C1_MACFA, F; Q505F1    , NR2C1_MOUSE, F;
DR   Q5RCZ5    , NR2C1_PONAB, F; Q8VIJ4    , NR2C1_RAT  , F;
DR   Q28CK1    , NR2C1_XENTR, F; P24021    , NUS1_ASPOR , F;
DR   B8YEK4    , OGR1_ORYSJ , F; A4IFJ5    , PA24A_BOVIN, F;
DR   P49147    , PA24A_CHICK, F; P50392    , PA24A_DANRE, F;
DR   O77793    , PA24A_HORSE, F; P47712    , PA24A_HUMAN, F;
DR   P47713    , PA24A_MOUSE, F; Q5R8A5    , PA24A_PONAB, F;
DR   Q9TT38    , PA24A_RABIT, F; P50393    , PA24A_RAT  , F;
DR   Q7T0T9    , PA24A_XENLA, F; B1WAZ6    , PA24A_XENTR, F;
DR   Q8TXD4    , PDAD_METKA , F; A0KEL3    , PEPQ_AERHH , F;
DR   A4STF0    , PEPQ_AERS4 , F; O29805    , PGP_ARCFU  , F;
DR   Q14IC9    , PNP_FRAT1  , F; A7NDP3    , PNP_FRATF  , F;
DR   Q2A269    , PNP_FRATH  , F; B2SDK7    , PNP_FRATM  , F;
DR   A0Q5I9    , PNP_FRATN  , F; Q0BKU1    , PNP_FRATO  , F;
DR   Q5NGX7    , PNP_FRATT  , F; A4IZA6    , PNP_FRATW  , F;
DR   Q9M2A1    , PP263_ARATH, F; P55826    , PPOC_ARATH , F;
DR   A7LBL2    , PURA_LEIDO , F; A4HVP7    , PURA_LEIIN , F;
DR   Q4QG35    , PURA_LEIMA , F; Q7MY25    , PYRE_PHOLL , F;
DR   Q8E9L5    , PYRE_SHEON , F; Q9KVD5    , PYRE_VIBCH , F;
DR   Q2FHZ1    , RNJ1_STAA3 , F; Q2FZG9    , RNJ1_STAA8 , F;
DR   Q2YX35    , RNJ1_STAAB , F; Q5HGZ5    , RNJ1_STAAC , F;
DR   Q99V09    , RNJ1_STAAM , F; Q7A682    , RNJ1_STAAN , F;
DR   Q6GHZ6    , RNJ1_STAAR , F; Q6GAC5    , RNJ1_STAAS , F;
DR   Q7A171    , RNJ1_STAAW , F; Q5HQ80    , RNJ1_STAEQ , F;
DR   Q8CT16    , RNJ1_STAES , F; Q4L5A3    , RNJ1_STAHJ , F;
DR   Q49WL3    , RNJ1_STAS1 , F; Q1IHH4    , RPOB_KORVE , F;
DR   A0T0Q8    , RR2_THAPS  , F; O74300    , SC6_SCHCO  , F;
DR   Q98RA6    , SECA_MYCPU , F; Q9UTE0    , SEY1_SCHPO , F;
DR   O14362    , SMI1_SCHPO , F; P33894    , STE13_YEAST, F;
DR   Q3SK29    , SYFB_THIDA , F; O34104    , T2S1_LACLC , F;
DR   Q9UKZ4    , TEN1_HUMAN , F; Q9WTS4    , TEN1_MOUSE , F;
DR   Q9C7B1    , TRP3_ARATH , F; P27235    , VL2_HPV42  , F;
DR   Q9CG78    , XERS_LACLA , F; A2RKP9    , XERS_LACLM , F;
DR   Q02YZ4    , XERS_LACLS , F; Q23229    , XOL1_CAEEL , F;
DR   O84075    , Y072_CHLTR , F; P9WQJ1    , Y1273_MYCTU, F;
DR   P0A4W5    , Y1304_MYCBO, F; Q8FPK2    , Y1776_COREF, F;
DR   Q9PKW7    , Y344_CHLMU , F; P55529    , Y4KK_SINFN , F;
DR   A4T1E2    , Y5194_MYCGI, F; Q58383    , Y973_METJA , F;
DR   P54718    , YFIB_BACSU , F; Q17405    , YQ02_CAEEL , F;
DR   Q74ZC0    , YSH1_ASHGO , F; Q6C2Z7    , YSH1_YARLI , F;
3D   1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU;
3D   1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI;
3D   1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5;
3D   1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64;
3D   1R6V; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ;
3D   1SCN; 1SEL; 1SIB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN;
3D   1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN;
3D   1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48;
3D   1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2E1P; 2G4V; 2HD4;
3D   2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC;
3D   2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 2Z2X; 2Z2Y; 2Z2Z; 2Z30; 2Z56; 2Z57;
3D   2Z58; 2ZRQ; 2ZWO; 2ZWP; 3A3N; 3A3O; 3A3P; 3AFG; 3AJ8; 3AJ9; 3BX1; 3D9Q;
3D   3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS;
3D   3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F7M; 3GT3; 3GT4; 3I2Y; 3I30; 3I34; 3I37;
3D   3L1K; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VHQ; 3VSB;
3D   3VV2; 3VYV; 3WHI; 3WIU; 3WIV; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5;
3D   4DWW; 4DZT; 4FON; 4JP8; 4MZD; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC; 4Z2A; 4ZAR;
3D   5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1; 5GL8; 5I9S;
3D   5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL; 5OX2; 5SIC;
3D   5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB; 6EQV; 6EQW;
3D   6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD; 6KKF; 6MH6; 6N4U;
3D   6O44; 6PKJ; 6PKK; 6PKL; 6PKM; 6PKN; 6PKO; 6PKP; 6PKQ; 6PKR; 6PKS; 6PKT;
3D   6PU4; 6PU5; 6QF1; 6QXV; 6RUG; 6RUH; 6RUK; 6RUN; 6RUW; 6RVE; 6RVG; 6RZP;
PR   PRU10080;
DO   PDOC00125;
//
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