KEGG   Panthera tigris altaica (Amur tiger): 102949488
Entry
102949488         CDS       T02988                                 
Symbol
PLCE1
Name
(RefSeq) phospholipase C epsilon 1
  KO
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg00562  Inositol phosphate metabolism
ptg01100  Metabolic pathways
ptg04014  Ras signaling pathway
ptg04015  Rap1 signaling pathway
ptg04020  Calcium signaling pathway
ptg04024  cAMP signaling pathway
ptg04070  Phosphatidylinositol signaling system
ptg04919  Thyroid hormone signaling pathway
ptg04933  AGE-RAGE signaling pathway in diabetic complications
ptg05205  Proteoglycans in cancer
Module
ptg_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102949488 (PLCE1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    102949488 (PLCE1)
   04015 Rap1 signaling pathway
    102949488 (PLCE1)
   04020 Calcium signaling pathway
    102949488 (PLCE1)
   04070 Phosphatidylinositol signaling system
    102949488 (PLCE1)
   04024 cAMP signaling pathway
    102949488 (PLCE1)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    102949488 (PLCE1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    102949488 (PLCE1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102949488 (PLCE1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptg04131]
    102949488 (PLCE1)
Enzymes [BR:ptg01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102949488 (PLCE1)
Membrane trafficking [BR:ptg04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102949488 (PLCE1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102949488 (PLCE1)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y RasGEF RA C2 EF-hand_like
Other DBs
NCBI-GeneID: 102949488
NCBI-ProteinID: XP_015392144
Position
Un
AA seq 1994 aa
MVSKGSAAGRGFAGMEEVRQLHVRFCKGIKIWHRXWFLCSLLGREPGEREAGCQLGLCTL
SARLRVGWLFPLSAAHSFTLLKDGCGCWRLKEDQIYNAVRRREEIENTIGSLLHFFTKLP
ASETAHERIRVGPCLKQCVRDTICEYRATLQRTSISQYIVGSLLEATTSLGARSGLLSTF
GGSTGRMMLKERQPGTSMANSSALPSSSAGISKELIDLQPLIQFPEEVASILMEQEQNIY
RRVLPVDYLCFLTRDLGSPECQTSLPCLKASISASILNSQNGEHNALEDLVMRFNEVSSW
VTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSD
LETMRSLKDAMAQHESSCEYKKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLMKLC
PRYNSQEETLEFVADYSGQDNFLQRVGHNGLKNSEKESTVNSIFQIIRSCSRSLEAEEED
SPSEGNSSRKNSLRDKARWQFIIGDLLDSENDIFEKSKEWDAHGSEEPQKAFDHGTELIP
WYVLSIRADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWTKPTTASLASAKAK
LGVLSNTSEPGKFPLLGNAGLSGLAEGVLDLFSAKAVYMGHPSIDIHTVCVQNKLGSMFL
SETGVTLLYGLQTTDNRLLHFVAPRHTAKMLFSGLLELTRAVRKMRKFPDQRQQWLRKQY
ASLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGTSAKSAEKPNVQRNNTLGISTTKKK
KKILIRGESGEAADDEMATRKAKMHRECRSRSGSDPQDMNEQEESEANAIMSPPNTLPSR
RAHSLTTAGSPNLSAGTSSPNRPVSSPVLSSSNKSPSSAWSSSSWHGRIKGGMKGFQSFM
VSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCNRAGSESVPLYTNLTIDENTSDL
QPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGVESTSLGVFGVGIL
ELNDFLVNCQGEHCTYDEILSIIQKFEPSVSMCHQGLLSFEGFARFLMDKDNFASKNDES
QENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWDGDDGL
PIIYHGHTLTTKIPFKEVVEAIERSAFVNSDLPIIISIENHCSLPQQRKMAEIFKSVFGE
KLVAKFLFESDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQAQAY
NGGNANPPPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRI
KKADNSACNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASG
SSRGKERKSRKSIFGNNPGRMSPGETASFNKASGKSSCEGMRQAWEESSSPLNPTTSLSA
IIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPLMFWLH
GIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDNME
PAIYSLTIVSGQNVCPSSSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFR
VHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFINSRR
MEENSSSSTTPASLMFNSEERKCLQAHRVTVHGVPGPEPFTVFSISGGTKAKQLLQQILT
TEQDTKPIITDYFLMEEKYFISKEKNECRKQPFQRVIGPEEEIMQILSSWFPEEGYVGRI
VLKTQQENLEEKSIVQDDKEVTLSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQ
TLCKAKYSYSILSNPNPSDYVLLEEVVKDTTKKSSTPKSSQRVLLDQECVFQAQSKWKGA
GKFILKLKEQVQASREDKRKGISFASEFKKFTKSTKQPRGLASPSQVLASEGVQNKEEKP
MGSLSSGDTMEYRQ
NT seq 5985 nt   +upstreamnt  +downstreamnt
atggtttcaaaaggaagtgcagcaggaagaggctttgcaggaatggaagaggtgaggcag
cttcatgtgagattctgcaaagggattaagatttggcaccgancttggtttctgtgcagc
ctcttaggcagagagcctggggagagggaagcgggctgtcagctggggctttgcacactc
tcagcccgcctcagggttgggtggcttttccctctctctgcagcacacagttttacctta
ttaaaggatggatgtggatgctggaggcttaaggaagaccagatctacaatgcagtgaga
aggagagaagaaatagaaaatacaattggatctcttcttcatttcttcacaaagcttcca
gcctctgaaacagcccatgaaaggattagggttggtccgtgcttaaagcaatgtgtccga
gataccatatgtgagtaccgtgccaccctccagaggacgtccatatctcagtacatcgtg
ggttctctgctagaagcaaccacatctttaggagcaagaagtggcctactcagtaccttt
ggaggatccaccggacgaatgatgctaaaagaacgtcagccaggcacctccatggccaat
tctagtgccctcccttcaagttcagctgggatcagcaaggagctgattgatctgcagccc
ctcattcagttcccagaggaagtcgccagcatcctgatggagcaggaacagaacatttac
cgaagggtcttgccagttgactacctttgcttcttgacccgggacttgggctctccagaa
tgccagacatccctgccctgcctcaaagcgtccatctcagcatcaattcttaactcccag
aacggagaacacaatgccctggaagatcttgtgatgagatttaatgaggtgagctcctgg
gtaacgtggctgatcctcaccgcgggctccatggaggagaagcgagaagtcttctcctat
ttggtgcacgtggccaaatgctgctggaacatgggcaactacaatgctgtcatggagttc
ttggccggcctcaggtcaagaaaagttttaaaaatgtggcagtttatggaccagtctgac
ctagagaccatgaggagcctgaaggatgccatggctcagcacgaatcttcctgcgagtac
aagaaggtggtcacgcgggctctgcacatacctggctgtaaggtggttccgttctgtggg
gtgtttctgaaggagctctgtgaagtactggacggagcctccggcctcatgaagctttgc
ccaaggtacaattcccaagaagaaactctagagtttgtagccgattacagcggacaagat
aatttcttacaacgagtgggacataatggcttaaagaattcggagaaagagtccacagtc
aacagcatctttcagatcatcaggagctgcagtcgaagtctggaggccgaggaggaggac
agccccagtgaaggaaacagctccaggaaaaattccttaagggataaagcccgatggcag
tttatcattggagacctgttagattctgaaaatgacatctttgagaaatccaaagaatgg
gacgctcacggatcagaagagccacagaaggcctttgaccatgggacagagctaatccca
tggtacgtgctgtccatccgagccgatgtgcaccagttcctgctgcagggggccactgtc
atccactacgaccaggacacgcacctctctgcccgatgcttcctccagcttcagcctgac
aacagcaccttgacctggacaaagcccaccactgcttccctggccagtgctaaagcaaaa
ctcggtgtgcttagtaacacgtctgagcctggcaaattcccgttactgggcaatgctgga
ctaagtggcctggcagagggggtcttggatctgttctcagcaaaagctgtgtacatggga
caccctagcatcgatatacacactgtgtgtgttcagaacaaactgggtagcatgtttctc
tcagagactggcgtgacgctgctctatgggctccagaccacggacaatagattattgcac
tttgtggcacccaggcacacagctaagatgctcttcagtggattgctggaactcacgaga
gccgtgaggaagatgaggaagttccctgaccagagacagcagtggctgcggaaacagtac
gccagcctctatcaggaagatggacggtacgaaggcccaactttggctcacgccgtggag
ttgtttggtggcaggcggtggagtacacgaaaccccagccccgggacatcagcaaagagt
gccgagaagcccaatgtgcaaagaaacaacaccttgggcataagcactaccaagaaaaag
aagaaaatccttataaggggtgagagcggagaggcagccgacgatgagatggccacccga
aaagccaaaatgcacagagagtgtcgcagccggagtggttctgaccctcaagacatgaat
gaacaagaagaatcagaggcaaatgccatcatgagccctcctaacactctgccttccaga
agagcccactctttgaccacggctgggtcccctaacttgtctgccgggacatcatctccc
aacaggccagtgtcttcccctgtgctgtcttcttcaaacaagagcccgtccagtgcttgg
agcagcagcagctggcacgggcggatcaaaggcggaatgaaaggtttccagagcttcatg
gtttcagacagtaacatgagctttgttgaattcgttgagctgttcaaatcattcagcgtg
aggagccgcaaggacctgaaggacctcttcgacgtctacgccgtgccctgcaaccgagcc
ggctccgagtcggtgccgctctacaccaacctaacaattgacgaaaacaccagcgatctt
cagcctgacctagatttattgaccagaaatgtctcggatttggggttgttcattaagagt
aaacagcagctgtcagacaaccagaggcagatatctgatgccattgctgctgcaagtatc
gtgacaaacggcactggggtcgagagcacatccttgggcgtgtttggggttggcatcctc
gagctcaatgacttcctagtgaactgccaaggagaacactgcacttatgatgaaatcctc
agcatcatccagaagttcgagcctagcgttagtatgtgtcatcagggcctactgtcattt
gaaggatttgcaaggtttctgatggataaagataatttcgcctcgaaaaatgatgagtca
caggaaaacattaaagaactacagctgcccctctcctactattacattgaatcttcacac
aatacctacctcacaggccaccagctcaaaggagagtcctcagtagaactctacagccag
gtcctcctgcaaggctgtaggagcatagagctggattgttgggatggagacgacgggttg
cccatcatctatcatggacacacgctgacaaccaagatccccttcaaggaggtggttgaa
gccattgaacgcagtgcctttgtcaactctgacctgcccatcatcatatcgattgagaac
cactgctcattgcctcagcaacgaaaaatggcagaaattttcaagagtgtgtttggagaa
aaactggtggctaagttcctgtttgagagtgatttctcagatgacccaatgcttccctca
cccgaccaacttaggaggaaagtgctccttaaaaataagaagctaaaagcccaccaaaca
ccagtggatatcttaaagcaaaaggctcatcagttagcatccatgcaagctcaggcttac
aatggtgggaatgccaaccccccaccggctaataacgaggaagaggaggatgaagaagac
gaatatgattacgactatgaatccctgtctgatgacaacattctagaagacagacctgaa
aataaatcatgtaatgacaagcttcagtttgagtataatgaagaaatccccaagaggata
aagaaagcagataactctgcttgcaacaaaggaaaggtttatgacatggaactgggagaa
gagttttatctccctcagaataaaaaagaaagcagacagattgcaccagagctctctgac
cttgtcatctattgccaagcagtaaaatttccaggcctgtcaactctaaatgcatctggc
tctagcagaggaaaagaaaggaaaagcaggaagtccatttttggcaacaatccgggcaga
atgagccctggggagacagcatcgtttaacaaagcatctggaaaaagttcctgtgaagga
atgcgacaggcctgggaggaatcttcttcccccctcaacccaaccacatccctcagcgct
atcattagaactcccaaatgttaccatatctcctcgctgaatgaaaatgccgccaaacgt
ctgtgtcgcaggtattctcagaaactgatccagcacaccgcctgtcagctgctgaggact
tacccggctgccactcgcatcgactcctccaaccccaatcccctcatgttctggctccat
gggatacagctcgtggcgctcaactaccagacagatgatctccctttacatttaaatgct
gccatgtttgaagccaacggtgggtgtggttatgttttgaaacccccagttctgtgggac
aagaactgtcccatgtatcagaagttctctcccttagaaagagatctggacaacatggag
cctgccatctactccttaactattgtctctggtcaaaacgtgtgcccgagtagcagcaca
ggaagcccgtgtatcgaagtcgatgtgctgggcatgcccctggacagctgccatttccgc
acaaagcccatccaccggaacactctgaaccccatgtggaatgaacagtttctcttccgg
gttcactttgaagatctcgtatttcttcgttttgccgttgtggaaaacaacagctcagct
gtaactgctcagagaatcatcccactcaaggctttaaaacgaggatatcgacatcttcag
ctgcgaaatctccacaacgaagtcttggaaatctctagtttattcataaacagtaggagg
atggaagaaaattcctccagcagcaccacgccggcctctttgatgtttaattcagaagaa
agaaaatgtttgcaggctcacagagtcacggtgcatggggtcccaggtccagagcccttt
actgttttctccataagtggaggcaccaaagcaaagcagcttctccaacaaattctgacc
actgaacaagacaccaaacctatcatcacagactattttttgatggaagaaaaatatttt
atatctaaagaaaagaatgaatgcaggaaacaaccgttccagagagtcattggtccagag
gaagagattatgcagattttaagcagctggtttccagaggaaggatatgttggcaggatt
gtcttaaaaacccagcaggaaaacctagaagagaaaagcattgttcaagatgacaaagag
gtgaccttgagctcagaggaggagagtttctttgttcaagtgcacgatgtttctccagag
caacctcgaacggtcatcaaagcaccccgtgtcagcaccgcacaggacgtcattcagcag
accttatgcaaagcaaagtattcctacagcatcctgagcaatcccaacccaagtgactat
gtgcttttggaagaggtggtaaaagacacgaccaagaagtcttccaccccaaagtcctcc
cagcgggtccttttggatcaggagtgtgtgtttcaagcccaaagcaagtggaaaggggca
ggaaaattcatccttaagctaaaggagcaggtgcaggcatcccgagaagacaaaaggaaa
ggcatttcttttgcaagtgaatttaagaagttcaccaagtcaactaaacaaccccgagga
ctcgcatcaccttctcaggtcttggcctcagaaggtgtccaaaacaaggaggagaaacct
atgggcagcttgtcctccggtgacaccatggagtatcgacaataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (11)   
   KEGG PATHWAY (10)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (6)   
   Pfam (6)   
All databases (39)   

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