KEGG   Panthera tigris altaica (Amur tiger): 102953204
Entry
102953204         CDS       T02988                                 
Symbol
TYK2
Name
(RefSeq) tyrosine kinase 2
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
ptg  Panthera tigris altaica (Amur tiger)
Pathway
ptg04217  Necroptosis
ptg04380  Osteoclast differentiation
ptg04620  Toll-like receptor signaling pathway
ptg04621  NOD-like receptor signaling pathway
ptg04630  JAK-STAT signaling pathway
ptg04658  Th1 and Th2 cell differentiation
ptg04659  Th17 cell differentiation
ptg05145  Toxoplasmosis
ptg05160  Hepatitis C
ptg05161  Hepatitis B
ptg05162  Measles
ptg05164  Influenza A
ptg05165  Human papillomavirus infection
ptg05167  Kaposi sarcoma-associated herpesvirus infection
ptg05168  Herpes simplex virus 1 infection
ptg05169  Epstein-Barr virus infection
ptg05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:ptg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    102953204 (TYK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    102953204 (TYK2)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    102953204 (TYK2)
   04621 NOD-like receptor signaling pathway
    102953204 (TYK2)
   04658 Th1 and Th2 cell differentiation
    102953204 (TYK2)
   04659 Th17 cell differentiation
    102953204 (TYK2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102953204 (TYK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    102953204 (TYK2)
   05160 Hepatitis C
    102953204 (TYK2)
   05171 Coronavirus disease - COVID-19
    102953204 (TYK2)
   05164 Influenza A
    102953204 (TYK2)
   05162 Measles
    102953204 (TYK2)
   05168 Herpes simplex virus 1 infection
    102953204 (TYK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102953204 (TYK2)
   05169 Epstein-Barr virus infection
    102953204 (TYK2)
   05165 Human papillomavirus infection
    102953204 (TYK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102953204 (TYK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ptg01001]
    102953204 (TYK2)
Enzymes [BR:ptg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     102953204 (TYK2)
Protein kinases [BR:ptg01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   102953204 (TYK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kdo Kinase-like FERM_C_FAK1 RIO1 ABC1
Other DBs
NCBI-GeneID: 102953204
NCBI-ProteinID: XP_015391775
Position
Un
AA seq 1150 aa
MPLCRWGATTRDSRPDGDEAQPMVSRGGLKVLLHWAGPDGGDPWVTFSEATLTAEEVCIH
IAHKVGITPSCLNLFALFDAQAQVWLPPNHILEVSRDMNLTLYFRMRFYFRNWHSMNPQE
PAVYRCGPTRAKSSSEQAEQGVQLLDPASFEYLFEQGKHEFVNDVAPLWELSSEEEIHHF
KNESLGMAFLHLCHLALCHGIPLEKVAKKISFKDCIPRSFRLQLRRHNALTRLRLRRLFR
RFVRAFQPGTLVWYLGARGLGSPSLPPXGSVFWRVCLLGEGLRPICDTGTXGDAXGACPR
ENCAGDXAGTALLGFQGPSGDGCSRNPRAGPSGKKSKAQEVGNQPVDRPQEAPWAYFCDF
QDITHVVLKERHVSIHCQDKCLELTLPSRAVALSLVSLVDGYFRLTADSSHYLCREVAPP
RLVMSIRDGIHGPLLPGLGALPAWTPAHRPHPCHLPQAPGGQQLHLRKFPIELRAGSFEL
EGWDRSFPSVRELRTALQGCSLRVGDDCFSLRRCCLPRPGELSNLIIMRGSRASPGPLNL
SQLSFHRVCQDDISQLSHLGQGTRTNVYEGILRVGERGPKEGTADGGDPPTPSGDRGQEL
RVVLKVLDPSHHDIALAFYETASLMSQVSHVHLAFVHGVCVHGSENIMVTEYVEHGPLDV
WLRRERGHVPVAWKVAVAQQLASALSYLEDKSLVHGNVCGRNILLARLGLAEGTSPFIKL
SDPGVGLGALSREERVERIPWTAPECLSGGASTLTTAADKWGFGVTLLEICFDGEAPLQG
RGPSEKECFYQKQHQLPQPSCPELATLTSQCLTYEPAQRPSFRTILRDLTQLQPQNLADI
LAVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAGGG
PQLRTGWRREIDILRTLYHKHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHNVGL
AQLLLFAQQICEGMAYLHAQHYVHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRV
REDGDSPVFWYAPECLKECKFYYASDVWSFGVTMYELLTYCDSSQSPPSKFIELIGLTQG
QMTVLRLTELLERGERLPRPEKCPCEIYLLMKNCWEAEASFRPTFQNLIPILKTVQEKYQ
GQAASVFNVC
NT seq 3453 nt   +upstreamnt  +downstreamnt
atgcctctgtgccgttggggtgccaccaccagggacagcaggcctgatggggatgaggct
cagcccatggtctccaggggaggcctaaaggtccttctgcactgggctggccctgatggc
ggggacccctgggtcaccttcagcgaggccacactgaccgcagaggaggtctgcatccac
atcgcacacaaagtcggcatcactccatcctgcctcaatctcttcgccctctttgatgcc
caggcccaggtgtggctgcccccaaaccacatcttggaggtctccagagacatgaacctg
acattgtacttccgcatgaggttttatttccggaattggcacagcatgaatcctcaggag
ccggccgtgtaccgctgtgggcccaccagggccaagtcttcctcggaacaggcagagcag
ggcgtgcaactcctggacccagcctcctttgagtacctctttgagcagggcaagcacgag
tttgtgaatgatgtggcaccactgtgggagctgtcgagcgaggaggagatccaccatttt
aagaacgagagcctgggcatggcctttctgcacctctgccacctcgccctttgccatggt
atccccctggagaaggtggccaagaagatcagcttcaaggactgcatcccgcgctccttc
cggctgcagctccggcggcacaacgcgttaacacggctgcgcctacggagactcttccgc
aggtttgtgcgggccttccagccggggaccctcgtctggtacctgggggcgagagggctc
ggctccccctctcttcctccctgaggttctgtcttctggcgtgtgtgtctcttgggggaa
ggtctccgtcccatctgtgacacggggacttagggggatgcctgaggagcctgtccccgg
gaaaactgtgcgggggactaagctggcacggccctgctgggtttccagggtcccagtggc
gatggttgcagcaggaacccccgtgctggcccatcagggaagaaaagcaaggcccaggag
gtgggcaaccagccagtggacaggcctcaggaagcgccgtgggcctacttctgtgacttc
caggacatcacccacgtggtgctgaaagagcgccacgtcagcatccactgtcaggacaag
tgcctggagctcaccctgccttcccgggctgtggccctatccttggtgtcgctggtggac
ggctatttccgcctgacggccgactcgagccactacctgtgccgggaggtggcccctccg
cggctggtgatgagcatccgggatggcatccacgggcccttgctgccggggctgggcgcg
ctccctgcctggacccctgctcaccgcccccacccctgccacctaccccaggcacctggc
gggcagcagctgcacctccgtaaattccccattgagctgcgggccgggagcttcgagctg
gagggctgggaccgctccttcccgagcgtgcgggagctgcgcaccgccctgcagggctgc
tcgctgcgggtcggggacgactgtttctccctgcgccgctgctgcctgccacggcccgga
gagctctccaacctcatcatcatgcgtgggtctcgggccagccctgggccactcaacctc
agccagctcagcttccaccgcgtctgccaggatgacattagtcagctgtctcacttgggc
caaggcacgaggaccaatgtgtatgagggcatcttacgggtgggggaaagaggccccaag
gagggcacggcagatggtggggacccccccacgcccagtggggaccgtggccaggagcta
cgagtggtactcaaggtgctggatcccagtcaccacgacatcgccctggccttctacgag
acagccagcctcatgagccaggtctcccacgtgcacctggcctttgtgcacggcgtctgc
gtgcacggctctgagaacatcatggtgacagagtacgtggagcacggacccctggatgtg
tggctgcggcgggagaggggccacgtgcctgtggcctggaaggtggcagtggcccagcag
ctggccagcgctctcagctacctggaagacaagagcctggttcatggtaatgtgtgtggc
cggaacatcctgctggcacggctgggactggcggagggcaccagcccctttatcaagctg
agcgatcccggtgtgggcctgggtgccctttccagggaggagcgggtagagaggatcccc
tggacagcccccgagtgcctgtcaggtggggccagcaccctaaccactgcagctgacaaa
tggggctttggtgtcaccctcctggagatctgcttcgacggggaggcccctctgcagggc
cgcggcccttccgagaaagagtgcttctaccagaagcagcaccagcttcctcagccctca
tgcccggagctggccacactcaccagccagtgcctgacctatgaaccagctcagcggccc
tccttccgcaccatcctgcgtgacctcactcagctgcagccccagaatcttgctgacatc
ttggctgtgaaccccgactcgcctgcgtcagaccccaccgttttccacaagcgctatttg
aaaaagatccgggatctgggcgagggtcatttcggcaaggtcagtctgtattgctacgac
ccgactaacgacggcaccggcgagatggtggctgtgaaggccctcaaggcgggcgggggc
ccccagctccgcactggctggcggcgggagatcgacatcctgcgcacgctctaccacaag
cacatcgtcaaatacaagggatgctgcgaggaccaaggagagaagtcggtgcagctcgtt
atggagtacgtgcctctgggcagcctccgggactaccttccccggcacaacgtcggactg
gcccaactgctactcttcgcccagcagatctgtgagggcatggcctaccttcatgcacag
cactacgtccaccgagacctggctgcccgcaacgtgctgctggacaacgacaggctggtc
aaaatcggggactttggcctagccaaggctgtgcctgaaggccatgagtactaccgcgtg
cgcgaagatggggacagccccgtattctggtatgctccagagtgcctgaaggagtgtaag
ttctactatgcatccgacgtctggtccttcggggtcaccatgtatgagctgctgacctac
tgtgactccagccagagccccccttcgaaattcatcgagctcataggcctcacccaaggg
cagatgacggtgctgaggctcactgagctgctggaacgaggggagaggctgccgcggcca
gagaaatgcccttgcgagatctacctcctcatgaagaactgctgggaggcagaggcctca
ttccgccccactttccagaacctcatccccattctcaagacggtccaggagaaataccaa
ggccaggccgcctcagtgttcaatgtgtgctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (17)   
   KEGG PATHWAY (17)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (10)   
   Pfam (10)   
All databases (42)   

Download RDF
DBGET integrated database retrieval system