KEGG   Pan troglodytes (chimpanzee): 451290Help
Entry
451290            CDS       T01005                                 

Gene name
PLCB3
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ptr00562  Inositol phosphate metabolism
ptr01100  Metabolic pathways
ptr04015  Rap1 signaling pathway
ptr04020  Calcium signaling pathway
ptr04022  cGMP-PKG signaling pathway
ptr04062  Chemokine signaling pathway
ptr04070  Phosphatidylinositol signaling system
ptr04071  Sphingolipid signaling pathway
ptr04072  Phospholipase D signaling pathway
ptr04261  Adrenergic signaling in cardiomyocytes
ptr04270  Vascular smooth muscle contraction
ptr04310  Wnt signaling pathway
ptr04371  Apelin signaling pathway
ptr04540  Gap junction
ptr04611  Platelet activation
ptr04621  NOD-like receptor signaling pathway
ptr04713  Circadian entrainment
ptr04720  Long-term potentiation
ptr04723  Retrograde endocannabinoid signaling
ptr04724  Glutamatergic synapse
ptr04725  Cholinergic synapse
ptr04726  Serotonergic synapse
ptr04728  Dopaminergic synapse
ptr04730  Long-term depression
ptr04750  Inflammatory mediator regulation of TRP channels
ptr04911  Insulin secretion
ptr04912  GnRH signaling pathway
ptr04915  Estrogen signaling pathway
ptr04916  Melanogenesis
ptr04918  Thyroid hormone synthesis
ptr04919  Thyroid hormone signaling pathway
ptr04921  Oxytocin signaling pathway
ptr04922  Glucagon signaling pathway
ptr04924  Renin secretion
ptr04925  Aldosterone synthesis and secretion
ptr04926  Relaxin signaling pathway
ptr04927  Cortisol synthesis and secretion
ptr04928  Parathyroid hormone synthesis, secretion and action
ptr04933  AGE-RAGE signaling pathway in diabetic complications
ptr04934  Cushing's syndrome
ptr04961  Endocrine and other factor-regulated calcium reabsorption
ptr04970  Salivary secretion
ptr04971  Gastric acid secretion
ptr04972  Pancreatic secretion
ptr05010  Alzheimer's disease
ptr05016  Huntington's disease
ptr05142  Chagas disease (American trypanosomiasis)
ptr05143  African trypanosomiasis
ptr05146  Amoebiasis
ptr05163  Human cytomegalovirus infection
ptr05200  Pathways in cancer
Module
ptr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ptr00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    451290 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    451290 (PLCB3)
   04310 Wnt signaling pathway
    451290 (PLCB3)
   04371 Apelin signaling pathway
    451290 (PLCB3)
   04020 Calcium signaling pathway
    451290 (PLCB3)
   04070 Phosphatidylinositol signaling system
    451290 (PLCB3)
   04072 Phospholipase D signaling pathway
    451290 (PLCB3)
   04071 Sphingolipid signaling pathway
    451290 (PLCB3)
   04022 cGMP - PKG signaling pathway
    451290 (PLCB3)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    451290 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    451290 (PLCB3)
   04621 NOD-like receptor signaling pathway
    451290 (PLCB3)
   04062 Chemokine signaling pathway
    451290 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    451290 (PLCB3)
   04922 Glucagon signaling pathway
    451290 (PLCB3)
   04912 GnRH signaling pathway
    451290 (PLCB3)
   04915 Estrogen signaling pathway
    451290 (PLCB3)
   04921 Oxytocin signaling pathway
    451290 (PLCB3)
   04926 Relaxin signaling pathway
    451290 (PLCB3)
   04918 Thyroid hormone synthesis
    451290 (PLCB3)
   04919 Thyroid hormone signaling pathway
    451290 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    451290 (PLCB3)
   04916 Melanogenesis
    451290 (PLCB3)
   04924 Renin secretion
    451290 (PLCB3)
   04925 Aldosterone synthesis and secretion
    451290 (PLCB3)
   04927 Cortisol synthesis and secretion
    451290 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    451290 (PLCB3)
   04270 Vascular smooth muscle contraction
    451290 (PLCB3)
  Digestive system
   04970 Salivary secretion
    451290 (PLCB3)
   04971 Gastric acid secretion
    451290 (PLCB3)
   04972 Pancreatic secretion
    451290 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    451290 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    451290 (PLCB3)
   04725 Cholinergic synapse
    451290 (PLCB3)
   04728 Dopaminergic synapse
    451290 (PLCB3)
   04726 Serotonergic synapse
    451290 (PLCB3)
   04720 Long-term potentiation
    451290 (PLCB3)
   04730 Long-term depression
    451290 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    451290 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    451290 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    451290 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    451290 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    451290 (PLCB3)
   05016 Huntington's disease
    451290 (PLCB3)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    451290 (PLCB3)
   04934 Cushing's syndrome
    451290 (PLCB3)
  Infectious diseases
   05163 Human cytomegalovirus infection
    451290 (PLCB3)
   05146 Amoebiasis
    451290 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    451290 (PLCB3)
   05143 African trypanosomiasis
    451290 (PLCB3)
Enzymes [BR:ptr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     451290 (PLCB3)
Membrane trafficking [BR:ptr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    451290 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    451290 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y EF-hand_like C2 DUF1154 BPL_N
Motif
Other DBs
NCBI-GeneID: 451290
NCBI-ProteinID: XP_003313091
Ensembl: ENSPTRG00000003828
VGNC: 3067
UniProt: A0A2I3T8F7
Position
11
AA seq 1234 aa AA seqDB search
MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF
MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS
TGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD
EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL
GSQPSSNPTPSPLDASPRRPPGPTTSPTSTSLSSPGQRDDLIASILSEVAPTPLDELRGH
KALVKLRSRQERDVRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED
TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF
KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE
EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG
DGPLVACASNGHAPGSSRHLSGADSESQEENTQL
NT seq 3705 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgcccagcccggcgtccacgcgctgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggagacctccagtcggaacctg
gtgaccctgcgtgtggaccccaatggcttcttcttgtactggacgggccccaacatggag
gtggacacactggacatcagttccatcagggacacacggacaggccggtacgcccgcctg
cccaaggaccccaagatccgggaagttctgggctttgggggtcccgatgcccggctggag
gagaagctgatgacggtggtgtctgggccagacccggtgaacacagtgttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggtctgaggagctattcaagctggctatg
aacatcctggctcagaacgcctcccggaacaccttcctgcgcaaagcatacacgaaactg
aagctgcaggtgaaccaggatggtcggatccccgtcaagaacatcctgaagatgttctca
gcagacaagaagcgggtggagactgcgctggaatcctgtggcctcaaattcaaccggagt
gagtccatccggcccgatgagttttccttggaaatctttgagcgattcctgaacaagctg
tgtctgcggccggacattgacaagatcctgctggagataggcgcgaagggcaagccatac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgcgacccgagactcaac
gaagtgctgtacccgcccctgcggccctcccaggcccggctgctcatcgaaaagtatgag
cccaaccagcagtttctggagcgagaccagatgtccatggagggctttagccgctacctg
ggaggcgaggagaatggcatcctgcccctggaagccctggatctgagcacggacatgacc
cagccactgagtgcctacttcatcaactcctcgcataacacctatctcactgcggggcag
ctggctgggacctcgtcggtggagatgtaccgccaggcactgctatggggctgccgctgc
gtggagctggacgtgtggaagggacggccacccgaggaggaacccttcattacccacggc
ttcaccatgaccacggaggtgcctctgcgcgacgtgctggaggccattgccgagactgcc
ttcaagacgtcgccctaccccgtcatcctctccttcgagaaccatgtggactcggcaaag
caacaggcaaagatggctgagtactgccgctccatctttggagacgcgctactcatcgag
cctctggacaagtacccgctggccccaggcgttcccctgcccagcccccaggacctgatg
ggccgtatcctggtgaagaacaagaagcggcaccgacccagcgcaggtggcccagacagc
accgggcgcaagcggcccctggagcagagcaattctgccctgagcgagagctccgcggcc
accgagccctcctccccgcagttggggtctcccagctctgacagctgcccaggcctgagc
aatggggaggaggtagggcttgagaagcccagcctggagcctcagaagtctctgggcgac
gagggcctgaaccggggcccctatgttcttggacctgctgaccgtgaggatgaggaggaa
gatgaggaagaggaggaacagacagaccccaaaaagccaactacagatgagggcacagcc
agcagcgaggtgaatgccactgaggagatgtccacgcttgtcaactacatcgagcctgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaaatgcttcgagatgtcgtccttt
gtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aagcagcagctcagccgcatctaccccaagggcacccgcgtggactcctccaactacatg
ccccagctcttctggaacgtagggtgccagcttgttgcgctcaacttccagaccctcgat
gtggcgatgcagctcaacgcgggcgtttttgagtacaacgggcgcagcgggtacctgctc
aagccggagttcatgcggcggccggacaagtccttcgaccccttcactgaggtcatcgtg
gatggcatcgtggccaatgccttgcgggtcaaggtgatctcagggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggacatgtttggcctccctgttgacacgcggcgc
aagtaccgcacccggacctctcaggggaactcgttcaaccccgtgtgggacgaagagccc
ttcgacttccccaaggtggtgctgcccacgctggcttcacttcgcatcgcagcctttgag
gaggggggtaaattcgtagggcaccggatcctgcctgtctctgccatccgctccggatac
cactacgtctgcctgcggaacgaggccaaccaaccgctgtgcctgccggccctgctcatc
tacactgaagcctcggactacattcctgacgaccaccaggactacgcggaggccctgatc
aaccccattaagcacgtcagcctgatggaccagagggcccggcagctggccgccctcatt
ggggagagtgaggctcaggctggccaagagacgtgccaggacacccagtctcagcagctg
gggtctcagccgtcctcaaaccccacccctagcccactggatgcctccccccgccggccc
cctggccccaccacctcccctaccagcacctccctcagcagcccagggcagcgcgatgat
ctcatcgccagcatcctctcagaggtggcccccaccccgctggatgagctccgaggtcac
aaggctctggtcaagctccggagccggcaagagcgagacgtgcgggagctgcgcaagaag
catcagcggaaggcagtcaccctcacccgccgcctgctggatggcctggctcaggcacag
gctgagggcaggtgccggctgcggccaggtgccctaggtggggccgctgatgtggaggac
acgaaggagggggaggacgaggcaaagcggtatcaggagttccagaacagacaggtgcag
agcctgctggagctgcgggaggcccaggtggacgcagaggcccagcggaggctggaacac
ctgagacaggctctgcagcggctcagggaggtcgtccttgatgcaaacacaactcagttc
aagaggctgaaagagatgaacgagagggagaagaaggagctgcagaagatcctggacaga
aagcgccataacagcatctcggaggccaagatgagggacaagcataagaaggaggcggaa
ctgacggagattaaccgtcggcacatcactgagtcagtcaactccatccgtcggctggag
gaggcccagaagcagcggcatgaccgtcttgtggctgggcagcagcaggtcctgcaacag
ctggcagaagaggagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgg
gcgaggctcccccaggagatccgccggagcctgctgggcgagatgccggaggggctgggg
gacgggcctctggtggcctgtgccagcaacggtcacgcacccgggagcagcaggcacctg
tcgggcgctgactcggagagccaggaggagaacacgcagctctga

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