KEGG   Pan troglodytes (chimpanzee): 456565
Entry
456565            CDS       T01005                                 
Symbol
PIK3R3
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ptr  Pan troglodytes (chimpanzee)
Pathway
ptr01521  EGFR tyrosine kinase inhibitor resistance
ptr01522  Endocrine resistance
ptr01524  Platinum drug resistance
ptr04012  ErbB signaling pathway
ptr04014  Ras signaling pathway
ptr04015  Rap1 signaling pathway
ptr04024  cAMP signaling pathway
ptr04062  Chemokine signaling pathway
ptr04066  HIF-1 signaling pathway
ptr04068  FoxO signaling pathway
ptr04070  Phosphatidylinositol signaling system
ptr04071  Sphingolipid signaling pathway
ptr04072  Phospholipase D signaling pathway
ptr04140  Autophagy - animal
ptr04150  mTOR signaling pathway
ptr04151  PI3K-Akt signaling pathway
ptr04152  AMPK signaling pathway
ptr04210  Apoptosis
ptr04211  Longevity regulating pathway
ptr04213  Longevity regulating pathway - multiple species
ptr04218  Cellular senescence
ptr04360  Axon guidance
ptr04370  VEGF signaling pathway
ptr04380  Osteoclast differentiation
ptr04510  Focal adhesion
ptr04550  Signaling pathways regulating pluripotency of stem cells
ptr04611  Platelet activation
ptr04613  Neutrophil extracellular trap formation
ptr04620  Toll-like receptor signaling pathway
ptr04625  C-type lectin receptor signaling pathway
ptr04630  JAK-STAT signaling pathway
ptr04650  Natural killer cell mediated cytotoxicity
ptr04660  T cell receptor signaling pathway
ptr04662  B cell receptor signaling pathway
ptr04664  Fc epsilon RI signaling pathway
ptr04666  Fc gamma R-mediated phagocytosis
ptr04668  TNF signaling pathway
ptr04670  Leukocyte transendothelial migration
ptr04722  Neurotrophin signaling pathway
ptr04725  Cholinergic synapse
ptr04750  Inflammatory mediator regulation of TRP channels
ptr04810  Regulation of actin cytoskeleton
ptr04910  Insulin signaling pathway
ptr04914  Progesterone-mediated oocyte maturation
ptr04915  Estrogen signaling pathway
ptr04917  Prolactin signaling pathway
ptr04919  Thyroid hormone signaling pathway
ptr04923  Regulation of lipolysis in adipocytes
ptr04926  Relaxin signaling pathway
ptr04929  GnRH secretion
ptr04930  Type II diabetes mellitus
ptr04931  Insulin resistance
ptr04932  Non-alcoholic fatty liver disease
ptr04933  AGE-RAGE signaling pathway in diabetic complications
ptr04935  Growth hormone synthesis, secretion and action
ptr04960  Aldosterone-regulated sodium reabsorption
ptr04973  Carbohydrate digestion and absorption
ptr05010  Alzheimer disease
ptr05017  Spinocerebellar ataxia
ptr05020  Prion disease
ptr05100  Bacterial invasion of epithelial cells
ptr05135  Yersinia infection
ptr05142  Chagas disease
ptr05146  Amoebiasis
ptr05160  Hepatitis C
ptr05161  Hepatitis B
ptr05162  Measles
ptr05163  Human cytomegalovirus infection
ptr05164  Influenza A
ptr05165  Human papillomavirus infection
ptr05166  Human T-cell leukemia virus 1 infection
ptr05167  Kaposi sarcoma-associated herpesvirus infection
ptr05168  Herpes simplex virus 1 infection
ptr05169  Epstein-Barr virus infection
ptr05170  Human immunodeficiency virus 1 infection
ptr05171  Coronavirus disease - COVID-19
ptr05200  Pathways in cancer
ptr05203  Viral carcinogenesis
ptr05205  Proteoglycans in cancer
ptr05206  MicroRNAs in cancer
ptr05207  Chemical carcinogenesis - receptor activation
ptr05208  Chemical carcinogenesis - reactive oxygen species
ptr05210  Colorectal cancer
ptr05211  Renal cell carcinoma
ptr05212  Pancreatic cancer
ptr05213  Endometrial cancer
ptr05214  Glioma
ptr05215  Prostate cancer
ptr05218  Melanoma
ptr05220  Chronic myeloid leukemia
ptr05221  Acute myeloid leukemia
ptr05222  Small cell lung cancer
ptr05223  Non-small cell lung cancer
ptr05224  Breast cancer
ptr05225  Hepatocellular carcinoma
ptr05226  Gastric cancer
ptr05230  Central carbon metabolism in cancer
ptr05231  Choline metabolism in cancer
ptr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ptr05415  Diabetic cardiomyopathy
ptr05417  Lipid and atherosclerosis
ptr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ptr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    456565 (PIK3R3)
   04014 Ras signaling pathway
    456565 (PIK3R3)
   04015 Rap1 signaling pathway
    456565 (PIK3R3)
   04370 VEGF signaling pathway
    456565 (PIK3R3)
   04630 JAK-STAT signaling pathway
    456565 (PIK3R3)
   04668 TNF signaling pathway
    456565 (PIK3R3)
   04066 HIF-1 signaling pathway
    456565 (PIK3R3)
   04068 FoxO signaling pathway
    456565 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    456565 (PIK3R3)
   04072 Phospholipase D signaling pathway
    456565 (PIK3R3)
   04071 Sphingolipid signaling pathway
    456565 (PIK3R3)
   04024 cAMP signaling pathway
    456565 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    456565 (PIK3R3)
   04152 AMPK signaling pathway
    456565 (PIK3R3)
   04150 mTOR signaling pathway
    456565 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    456565 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    456565 (PIK3R3)
   04218 Cellular senescence
    456565 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    456565 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    456565 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    456565 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    456565 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    456565 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    456565 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    456565 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    456565 (PIK3R3)
   04660 T cell receptor signaling pathway
    456565 (PIK3R3)
   04662 B cell receptor signaling pathway
    456565 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    456565 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    456565 (PIK3R3)
   04670 Leukocyte transendothelial migration
    456565 (PIK3R3)
   04062 Chemokine signaling pathway
    456565 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    456565 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    456565 (PIK3R3)
   04929 GnRH secretion
    456565 (PIK3R3)
   04915 Estrogen signaling pathway
    456565 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    456565 (PIK3R3)
   04917 Prolactin signaling pathway
    456565 (PIK3R3)
   04926 Relaxin signaling pathway
    456565 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    456565 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    456565 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    456565 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    456565 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    456565 (PIK3R3)
   04722 Neurotrophin signaling pathway
    456565 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    456565 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    456565 (PIK3R3)
   04380 Osteoclast differentiation
    456565 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    456565 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    456565 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    456565 (PIK3R3)
   05206 MicroRNAs in cancer
    456565 (PIK3R3)
   05205 Proteoglycans in cancer
    456565 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    456565 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    456565 (PIK3R3)
   05203 Viral carcinogenesis
    456565 (PIK3R3)
   05230 Central carbon metabolism in cancer
    456565 (PIK3R3)
   05231 Choline metabolism in cancer
    456565 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    456565 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    456565 (PIK3R3)
   05212 Pancreatic cancer
    456565 (PIK3R3)
   05225 Hepatocellular carcinoma
    456565 (PIK3R3)
   05226 Gastric cancer
    456565 (PIK3R3)
   05214 Glioma
    456565 (PIK3R3)
   05221 Acute myeloid leukemia
    456565 (PIK3R3)
   05220 Chronic myeloid leukemia
    456565 (PIK3R3)
   05218 Melanoma
    456565 (PIK3R3)
   05211 Renal cell carcinoma
    456565 (PIK3R3)
   05215 Prostate cancer
    456565 (PIK3R3)
   05213 Endometrial cancer
    456565 (PIK3R3)
   05224 Breast cancer
    456565 (PIK3R3)
   05222 Small cell lung cancer
    456565 (PIK3R3)
   05223 Non-small cell lung cancer
    456565 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    456565 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    456565 (PIK3R3)
   05161 Hepatitis B
    456565 (PIK3R3)
   05160 Hepatitis C
    456565 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    456565 (PIK3R3)
   05164 Influenza A
    456565 (PIK3R3)
   05162 Measles
    456565 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    456565 (PIK3R3)
   05163 Human cytomegalovirus infection
    456565 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    456565 (PIK3R3)
   05169 Epstein-Barr virus infection
    456565 (PIK3R3)
   05165 Human papillomavirus infection
    456565 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    456565 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    456565 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    456565 (PIK3R3)
   05142 Chagas disease
    456565 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    456565 (PIK3R3)
   05017 Spinocerebellar ataxia
    456565 (PIK3R3)
   05020 Prion disease
    456565 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    456565 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    456565 (PIK3R3)
   05415 Diabetic cardiomyopathy
    456565 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    456565 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    456565 (PIK3R3)
   04931 Insulin resistance
    456565 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    456565 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    456565 (PIK3R3)
   01524 Platinum drug resistance
    456565 (PIK3R3)
   01522 Endocrine resistance
    456565 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ptr04131]
    456565 (PIK3R3)
Membrane trafficking [BR:ptr04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    456565 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 Transcrip_act Cupin_8 Exonuc_VII_L
Other DBs
NCBI-GeneID: 456565
NCBI-ProteinID: XP_016817599
Ensembl: ENSPTRG00000000685
VGNC: 11765
Position
1:complement(44849584..44984316)
AA seq 417 aa
MTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTL
RKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQ
QDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIK
IFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQ
ALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNVWLGIKNEDADENYFIN
EEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHC
VIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1254 nt   +upstreamnt  +downstreamnt
atgacttcagcagttccaaatggaatgaaggacagttctgtttctcttcaggatgcagaa
tggtactggggggatatttcaagggaggaggtaaatgacaaattgcgggatatgccagat
gggaccttcttggtccgagatgcctcaacaaaaatgcagggagattatactttgactttg
cggaagggaggcaataataagttaataaagatctatcaccgggatggtaaatatggcttt
tctgatcctctgacatttaattccgtggtggagctcattaaccactatcaccatgaatct
cttgctcagtacaatcccaaacttgatgtgaagctgatgtacccagtgtccagataccaa
caggatcagttggtaaaagaagataatattgatgcagtaggtaaaaaactgcaagaatac
cactctcagtatcaggagaagagtaaagagtatgataggctgtatgaagaatatactaga
acatcccaggaaatacagatgaagaggactgcaatagaagcttttaatgaaacaattaaa
atatttgaagagcagtgtcacacacaagaacaacatagcaaagaatatattgagcgattt
cgcagagaggggaatgaaaaggagattgaacgaattatgatgaattatgataaattgaaa
tcacgtctgggagagattcatgatagcaaaatgcgtctagagcaggatttgaagaaacaa
gctttggacaaccgagaaatagataaaaaaatgaatagtatcaaacctgacctgatccag
ctgcgaaagatccgagatcaacaccttgtatggctcaatcacaaaggagtgagacagaaa
cgcctgaatgtctggctgggaattaagaatgaggatgctgatgagaactattttatcaat
gaggaagatgaaaacctgccccattatgatgagaaaacctggtttgttgaggatatcaat
cgagtacaagcagaggacttgctttatgggaaacctgatggtgcattcttaattcgtgag
agtagcaagaaaggatgctatgcttgctctgtggtggccgatggggaagtgaagcactgt
gtgatctacagcactgctcggggctatggctttgcagagccctacaacctgtacagctct
ctgaaggagctagtgctccattaccagcagacatccttggttcagcacaacgactccctc
aacgtcaggcttgcctaccctgttcatgcacagatgccctcgctttgcagataa

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (102)   
   KEGG PATHWAY (102)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (7)   
   RefSeq(pep) (7)   
DNA sequence (11)   
   RefSeq(nuc) (7)   
   GenBank (2)   
   EMBL (2)   
Protein domain (5)   
   Pfam (5)   
All databases (145)   

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