Database: PubMedEntry: 156716
Original site: 156716
Herendeen SL, VanBogelen RA, Neidhardt FC.
Levels of major proteins of Escherichia coli during growth at different
J Bacteriol. 1979 Jul;139(1):185-94. doi: 10.1128/jb.139.1.185-194.1979.
The adaptation of Escherichia coli B/r to temperature was studied by measuring
the levels of 133 proteins (comprising 70% of the cell's protein mass) during
balanced growth in rich medium at seven temperatures from 13.5 to 46 degrees C.
The growth rate of this strain in either rich or minimal medium varies as a
simple function of temperature with an Arrhenius constant of approximately 13,500
cal (ca. 56,500 J) per mol from 23 to 37 degrees C, the so-called normal range;
above and below this range the growth rate decreases sharply. Analysis of the
detailed results indicates that (i) metabolic coordination within the normal
(Arrhenius) range is largely achieved by modulation of enzyme activity rather
than amount; (ii) the restricted growth that occurs outside this range is
accompanied by marked changes in the levels of most of these proteins; (iii) a
few proteins are thermometer-like in varying simply with temperature over the
whole temperature range irrespective of the influence of temperature on cell
growth; and (iv) the temperature response of half of the proteins can be
predicted from current information on their metabolic role or from their
variation in level in different media at 37 degrees C.
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