Database: PubMed
Entry: 16021519
LinkDB: 16021519
Original site: 16021519 
     Wang L, Zhu YF, Guo XJ, Huo R, Ma X, Lin M,
     Zhou ZM, Sha JH.
     A two-dimensional electrophoresis reference map of human ovary.
     J Mol Med (Berl). 2005 Oct;83(10):812-21. doi: 10.1007/s00109-005-0676-y. Epub
     The ovary plays a central role in oogenesis and gonadal hormone secretion.
     Proteomic analysis is a valuable approach for gaining an increased understanding 
     of the molecular nature of the ovary. In this work, two-dimensional
     electrophoresis for protein separation followed by matrix-assisted laser
     desorption/ionization mass spectrometry and database searches, identified 231
     protein spots corresponding to 138 individual proteins that were found in gels
     representing both the follicular and luteal phases. The data were used to
     construct a database online ( The identified
     proteins were functionally classified into seven groups: (1) cell
     signaling/communication, (2) cell division, (3) gene/protein expression, (4)
     metabolism, (5) cell structure and motility, (6) cell/organism defense, and (7)
     unclassified. Among the proteins identified, 47% had not been previously reported
     in the human ovary. In addition, a number of disease-related proteins were
     identified in this protein map, including some cancer- and polycystic ovarian
     syndrome-related proteins. Two proteins with phosphorylation were verified by
     Western blot analysis. Comparison of protein abundance between follicular and
     luteal stages produced seven protein spots that had been identified in our
     database. This study provides a preliminary reference map of normal human ovary
     that will form a basis for comparative studies on normal and pathological
     conditions of the human ovary and may serve as a potential tool for clinical
     diagnosis, therapeutics, and prognosis.

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