Database: PubMed
Entry: 16699499
LinkDB: 16699499
Original site: 16699499 
     Vodovar N, Vallenet D, Cruveiller S, Rouy Z, Barbe V, Acosta C,
     Cattolico L, Jubin C, Lajus A, Segurens B, Vacherie B, Wincker P,
     Weissenbach J, Lemaitre B, Medigue C, Boccard F.
     Complete genome sequence of the entomopathogenic and metabolically versatile soil
     bacterium Pseudomonas entomophila.
     Nat Biotechnol. 2006 Jun;24(6):673-9. doi: 10.1038/nbt1212. Epub 2006 May 14.
     Pseudomonas entomophila is an entomopathogenic bacterium that, upon ingestion,
     kills Drosophila melanogaster as well as insects from different orders. The
     complete sequence of the 5.9-Mb genome was determined and compared to the
     sequenced genomes of four Pseudomonas species. P. entomophila possesses most of
     the catabolic genes of the closely related strain P. putida KT2440, revealing its
     metabolically versatile properties and its soil lifestyle. Several features that 
     probably contribute to its entomopathogenic properties were disclosed.
     Unexpectedly for an animal pathogen, P. entomophila is devoid of a type III
     secretion system and associated toxins but rather relies on a number of potential
     virulence factors such as insecticidal toxins, proteases, putative hemolysins,
     hydrogen cyanide and novel secondary metabolites to infect and kill insects.
     Genome-wide random mutagenesis revealed the major role of the two-component
     system GacS/GacA that regulates most of the potential virulence factors

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