Database: PubMedEntry: 271964
Original site: 271964
Anderson L, Anderson NG.
High resolution two-dimensional electrophoresis of human plasma proteins.
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5421-5. doi: 10.1073/pnas.74.12.5421.
The two-dimensional electrophoretic technique of O'Farrell has been adapted to
the analysis of human plasma proteins, and 30 polypeptides have been identified
in the pattern produced. Genetic variants involving charge (isoelectric point) or
size (molecular weight in the presence of sodium dodecyl sulfate) changes should
be routinely detectable in at least 20 proteins at once, facilitating studies of
human mutation rates.
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