Database: PubMedEntry: 6339477
Original site: 6339477
Smith MW, Neidhardt FC.
Proteins induced by aerobiosis in Escherichia coli.
J Bacteriol. 1983 Apr;154(1):344-50. doi: 10.1128/jb.154.1.344-350.1983.
The role of protein induction and repression in the adaptation of Escherichia
coli to changes in the supply of oxygen and other electron acceptors is only
poorly understood. We have studied the changes in cellular protein composition
associated with this adaptation by measuring the levels of 170 individual
polypeptides produced during aerobic or anaerobic growth of E. coli, with and
without nitrate. Nineteen polypeptides had levels highest during aerobic growth.
These proteins include the enzymes of the pyruvate dehydrogenase complex, several
tricarboxylic acid cycle enzymes, superoxide dismutase, and
tetrahydropteroyltriglutamate transmethylase. The other aerobiosis-induced
proteins have not been identified. These polypeptides are major cellular proteins
during aerobic growth and display several different patterns of regulation in
response to medium composition. Induction ratios for oxygen ranged from 2.2 to
11.2, with one exceptional member, superoxide dismutase, increasing 71-fold with
aeration. Most of the proteins were also induced by nitrate during anaerobic
growth. The time course of induction after shifts in oxygen supply revealed
similarities in response among proteins of related function or metabolic
regulation class. These results are discussed in relation to previously reported
information on the identified aerobiosis-induced proteins.
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