KEGG   Rousettus aegyptiacus (Egyptian rousette): 107509353
Entry
107509353         CDS       T06036                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ray  Rousettus aegyptiacus (Egyptian rousette)
Pathway
ray01521  EGFR tyrosine kinase inhibitor resistance
ray01522  Endocrine resistance
ray04010  MAPK signaling pathway
ray04012  ErbB signaling pathway
ray04068  FoxO signaling pathway
ray04270  Vascular smooth muscle contraction
ray04650  Natural killer cell mediated cytotoxicity
ray04720  Long-term potentiation
ray04726  Serotonergic synapse
ray04730  Long-term depression
ray04810  Regulation of actin cytoskeleton
ray04910  Insulin signaling pathway
ray04914  Progesterone-mediated oocyte maturation
ray04928  Parathyroid hormone synthesis, secretion and action
ray05010  Alzheimer disease
ray05022  Pathways of neurodegeneration - multiple diseases
ray05034  Alcoholism
ray05160  Hepatitis C
ray05161  Hepatitis B
ray05200  Pathways in cancer
ray05205  Proteoglycans in cancer
ray05208  Chemical carcinogenesis - reactive oxygen species
ray05210  Colorectal cancer
ray05211  Renal cell carcinoma
ray05212  Pancreatic cancer
ray05213  Endometrial cancer
ray05214  Glioma
ray05215  Prostate cancer
ray05218  Melanoma
ray05219  Bladder cancer
ray05220  Chronic myeloid leukemia
ray05221  Acute myeloid leukemia
ray05223  Non-small cell lung cancer
ray05224  Breast cancer
ray05225  Hepatocellular carcinoma
ray05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ray00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    107509353 (ARAF)
   04012 ErbB signaling pathway
    107509353 (ARAF)
   04068 FoxO signaling pathway
    107509353 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    107509353 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    107509353 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    107509353 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    107509353 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    107509353 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    107509353 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    107509353 (ARAF)
   04720 Long-term potentiation
    107509353 (ARAF)
   04730 Long-term depression
    107509353 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107509353 (ARAF)
   05205 Proteoglycans in cancer
    107509353 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    107509353 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107509353 (ARAF)
   05212 Pancreatic cancer
    107509353 (ARAF)
   05225 Hepatocellular carcinoma
    107509353 (ARAF)
   05226 Gastric cancer
    107509353 (ARAF)
   05214 Glioma
    107509353 (ARAF)
   05221 Acute myeloid leukemia
    107509353 (ARAF)
   05220 Chronic myeloid leukemia
    107509353 (ARAF)
   05218 Melanoma
    107509353 (ARAF)
   05211 Renal cell carcinoma
    107509353 (ARAF)
   05219 Bladder cancer
    107509353 (ARAF)
   05215 Prostate cancer
    107509353 (ARAF)
   05213 Endometrial cancer
    107509353 (ARAF)
   05224 Breast cancer
    107509353 (ARAF)
   05223 Non-small cell lung cancer
    107509353 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    107509353 (ARAF)
   05160 Hepatitis C
    107509353 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    107509353 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    107509353 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    107509353 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107509353 (ARAF)
   01522 Endocrine resistance
    107509353 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ray01001]
    107509353 (ARAF)
Enzymes [BR:ray01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     107509353 (ARAF)
Protein kinases [BR:ray01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   107509353 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 107509353
NCBI-ProteinID: XP_015997299
Position
Unknown
AA seq 688 aa
MWCLEIQIYFLSPATVLPDYHYQTSEFLLCLLGAPWHLPSPTSALLDKVLGSMEPPRAPP
ANGADPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGR
KTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTC
GYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGGSRQHEAPSNRPLNEPLTPQGPSLS
PDSSCTQHLDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSSLIQLTTQSFSTDG
EPPLPAPSAHPSTLLVSTHFSTITAAGNRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQ
RERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVL
KVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVAD
TRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWS
GAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQI
IFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIE
RSASEPSLHRTQADELPACLLSAARLVP
NT seq 2067 nt   +upstreamnt  +downstreamnt
atgtggtgcctggagattcaaatttattttttgtcccctgctactgtgcttccagactat
cattatcagacctctgaattcctcctctgtcttctaggagccccatggcacctacccagc
cccacctcagcccttcttgacaaagtcctaggctcaatggagccaccacgggccccccct
gccaatggggctgacccgtcccgggcagtgggcactgtcaaagtgtacttgcccaacaag
caacgcacggtggtgactgtccgggatggcatgagtgtctatgactctttagacaaggcc
ctcaaggtacggggtctcaatcaggattgctgcgtggtctaccggctcatcaagggacga
aagacggtcactgcctgggacacagccattgctcccctggatggcgaggagctcattgtg
gaggtccttgaagatgtcccactgaccatgcacaattttgtacggaagacgttcttcagc
ctggcattctgtgacttctgccttaagtttctgttccatggcttccgctgccaaacctgt
ggctacaagttccaccagcattgttcctccaaagtccccacagtctgtgttgatatgagt
accaaccgccgacagttctaccacagtgtccaggatttgtccggaggctccagacagcac
gaggctccctcaaaccgccccctgaatgagccgctaacccctcagggtcccagcctttcc
cctgacagctcctgcacccagcacctcgaccctgagcacttccccttccctgccccagcc
aatgcccctctccagcgcatccgctccacatccacccccaatgtccatatggtcagcacc
acagcccccatggactccagcctcatccagctcactacccagagtttcagcactgatggt
gagcccccgctgcctgcaccctcagcacacccttccaccctacttgtctccactcacttc
tccacaatcacagctgctggtaatagaggtggtggagatggagccccccgggggagcccc
agcccagccagcgtgtcctcagggaggaagtccccacattccaagtccccatcagaacag
cgggagcggaagtccttggccgatgacaagaagaaagtgaagaatctggggtaccgggat
tcgggctattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacg
ggctcatttggcaccgtgtttcgcgggcggtggcatggcgatgtggctgtgaaggtgctc
aaggtggcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctc
aggaagacacgtcatgtcaacatcttgctgttcatgggcttcatgacccggccggggttc
gccatcatcacacagtggtgtgagggctccagcctctaccaccacctccatgtagctgac
acacgttttgacatggtccagctcattgatgtggcccggcagactgcccagggcatggac
tacctccatgccaagaacatcatccaccgagatctcaagtctaacaacatctttttacac
gagggactcacagtgaagattggtgactttggcctggccacagtgaagacacggtggagc
ggagctcagcctctggaacagccctcaggctctgtgctatggatggcggctgaggtgatt
cgtatgcaggacccgaacccctacagcttccagtcggatgtctacgcctatggggttgtg
ctctatgagctcatgactggctccctaccttacagccacattggcagccgtgaccagatt
atctttatggtgggccgtggctatctgtctcctgacctcagcaaaatctctagtaactgc
cccaaagccatgcgacgcctgctgtccgactgcctgaagttccagcgggaggagcggcct
ctcttcccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgag
cggagtgcctcagaaccttccttgcaccgtacccaggctgatgagttgcccgcctgccta
ctcagcgcagcccgccttgtgccttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (36)   
   KEGG PATHWAY (36)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (7)   
   RefSeq(pep) (7)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (10)   
   Pfam (10)   
All databases (68)   

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