KEGG   REACTION: R00256Help
Entry
R00256                      Reaction                               

Name
L-glutamine amidohydrolase
Definition
L-Glutamine + H2O <=> L-Glutamate + Ammonia
Equation
Comment
the first step of several ligases (ec 6.3.5.x) using glutamine as amide-N-donor
ec 6.3.5.4 (see R00578, R00256+R00483)
ec 6.3.5.5 (see R00575, R00256+R10948+R10949+R01395)
Reaction class
RC00010  C00025_C00064
RC02798  C00014_C00064
Enzyme
1.4.1.13        1.4.7.1         3.5.1.2         3.5.1.38        
4.3.3.6         6.3.4.2         6.3.5.2         6.3.5.4         
6.3.5.5
Pathway
rn00220  Arginine biosynthesis
rn00250  Alanine, aspartate and glutamate metabolism
rn00471  D-Glutamine and D-glutamate metabolism
rn01100  Metabolic pathways
Orthology
K01425  glutaminase [EC:3.5.1.2]
K01954  carbamoyl-phosphate synthase [EC:6.3.5.5]
K01955  carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
K01956  carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
K05597  glutamin-(asparagin-)ase [EC:3.5.1.38]
K11540  carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
K11541  carbamoyl-phosphate synthase / aspartate carbamoyltransferase [EC:6.3.5.5 2.1.3.2]
Other DBs
RHEA: 15892

KEGG   REACTION: R00483Help
Entry
R00483                      Reaction                               

Name
L-aspartate:ammonia ligase (AMP-forming)
Definition
ATP + L-Aspartate + Ammonia <=> AMP + Diphosphate + L-Asparagine
Equation
Comment
second step of multi-step reaction (ec 6.3.5.4, see R00578, R00256+R00483)
Reaction class
RC00010  C00049_C00152
RC02798  C00014_C00152
Enzyme
6.3.1.1         6.3.5.4
Pathway
rn00250  Alanine, aspartate and glutamate metabolism
rn00460  Cyanoamino acid metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01230  Biosynthesis of amino acids
Orthology
K01914  aspartate--ammonia ligase [EC:6.3.1.1]
Other DBs
RHEA: 11375

KEGG   REACTION: R00578Help
Entry
R00578                      Reaction                               

Name
L-aspartate:L-glutamine amido-ligase (AMP-forming)
Definition
ATP + L-Aspartate + L-Glutamine + H2O <=> AMP + Diphosphate + L-Asparagine + L-Glutamate
Equation
Comment
two-step reaction (see R00256+R00483)
Reaction class
RC00010  C00025_C00064  C00049_C00152
Enzyme
Pathway
rn00250  Alanine, aspartate and glutamate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K01953  asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
Other DBs
RHEA: 12231

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