KEGG   REACTION: R01778
Entry
R01778                      Reaction                               
Name
(3S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
Definition
(3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
Equation
C00640 + C00003 <=> C00264 + C00004 + C00080
Comment
general reaction
the enzyme ec 1.1.1.35 has broad specificity to acyl chain-length, while ec 1.1.1.211 is long-chain specific
Reaction class
RC00001  C00003_C00004
RC00103  C00264_C00640
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
Module
M00085  Fatty acid elongation in mitochondria
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R01778  (3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
    1.1.1.211
     R01778  (3S)-3-Hydroxyacyl-CoA + NAD+ <=> 3-Oxoacyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
Other DBs
RHEA: 22435

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Pathway (3)   
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Chemical substance (5)   
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Chemical reaction (4)   
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Gene (1748)   
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KEGG   REACTION: R01975
Entry
R01975                      Reaction                               
Name
(S)-3-hydroxybutanoyl-CoA:NAD+ oxidoreductase
Definition
(S)-3-Hydroxybutanoyl-CoA + NAD+ <=> Acetoacetyl-CoA + NADH + H+
Equation
C01144 + C00003 <=> C00332 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00117  C00332_C01144
Enzyme
1.1.1.35
Pathway
rn00071  Fatty acid degradation
rn00310  Lysine degradation
rn00380  Tryptophan metabolism
rn00650  Butanoate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00087  beta-Oxidation
M00374  Dicarboxylate-hydroxybutyrate cycle
M00375  Hydroxypropionate-hydroxybutylate cycle
M00957  Lysine degradation, bacteria, L-lysine => glutarate => succinate/acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R01975  (S)-3-Hydroxybutanoyl-CoA + NAD+ <=> Acetoacetyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R01975  (S)-3-Hydroxybutanoyl-CoA <=> Acetoacetyl-CoA
Overall reaction [br08210.html]
 Carbon fixation
  R01975
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
K15016  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35]
Other DBs
RHEA: 30802

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Pathway (25)   
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Chemical substance (5)   
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Chemical reaction (5)   
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Gene (10428)   
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KEGG   REACTION: R04203
Entry
R04203                      Reaction                               
Name
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
Definition
(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
Equation
C04405 + C00003 <=> C03344 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00525  C03344_C04405
Enzyme
1.1.1.35        1.1.1.178
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
    1.1.1.178
     R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA + NAD+ <=> 2-Methylacetoacetyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04203  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylacetoacetyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K08683  3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]
Other DBs
RHEA: 13284

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Pathway (6)   
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Chemical substance (5)   
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KEGG   REACTION: R04737
Entry
R04737                      Reaction                               
Name
(S)-3-hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase
Definition
(S)-3-Hydroxyhexadecanoyl-CoA + NAD+ <=> 3-Oxopalmitoyl-CoA + NADH + H+
Equation
C05258 + C00003 <=> C05259 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00029  C05258_C05259
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04737  (S)-3-Hydroxyhexadecanoyl-CoA + NAD+ <=> 3-Oxopalmitoyl-CoA + NADH + H+
    1.1.1.211
     R04737  (S)-3-Hydroxyhexadecanoyl-CoA + NAD+ <=> 3-Oxopalmitoyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04737  (S)-3-Hydroxyhexadecanoyl-CoA <=> 3-Oxopalmitoyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04737  (S)-3-Hydroxyhexadecanoyl-CoA <=> 3-Oxopalmitoyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
Other DBs
RHEA: 31162

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Pathway (10)   
   KEGG PATHWAY (8)   
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Chemical substance (5)   
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Chemical reaction (5)   
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Gene (10745)   
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KEGG   REACTION: R04739
Entry
R04739                      Reaction                               
Name
(S)-3-hydroxytetradecanoyl-CoA:NAD+ oxidoreductase
Definition
(S)-3-Hydroxytetradecanoyl-CoA + NAD+ <=> 3-Oxotetradecanoyl-CoA + NADH
Equation
C05260 + C00003 <=> C05261 + C00004
Reaction class
RC00001  C00003_C00004
RC00029  C05260_C05261
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04739  (S)-3-Hydroxytetradecanoyl-CoA + NAD+ <=> 3-Oxotetradecanoyl-CoA + NADH
    1.1.1.211
     R04739  (S)-3-Hydroxytetradecanoyl-CoA + NAD+ <=> 3-Oxotetradecanoyl-CoA + NADH
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04739  (S)-3-Hydroxytetradecanoyl-CoA <=> 3-Oxotetradecanoyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04739  (S)-3-Hydroxytetradecanoyl-CoA <=> 3-Oxotetradecanoyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
Other DBs
RHEA: 31170

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Pathway (10)   
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Chemical substance (4)   
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Chemical reaction (4)   
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KEGG   REACTION: R04741
Entry
R04741                      Reaction                               
Name
(S)-3-hydroxydodecanoyl-CoA:NAD+ oxidoreductase
Definition
(S)-3-Hydroxydodecanoyl-CoA + NAD+ <=> 3-Oxododecanoyl-CoA + NADH + H+
Equation
C05262 + C00003 <=> C05263 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00029  C05262_C05263
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04741  (S)-3-Hydroxydodecanoyl-CoA + NAD+ <=> 3-Oxododecanoyl-CoA + NADH + H+
    1.1.1.211
     R04741  (S)-3-Hydroxydodecanoyl-CoA + NAD+ <=> 3-Oxododecanoyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04741  (S)-3-Hydroxydodecanoyl-CoA <=> 3-Oxododecanoyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04741  (S)-3-Hydroxydodecanoyl-CoA <=> 3-Oxododecanoyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
Other DBs
RHEA: 31182

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Pathway (10)   
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Chemical substance (5)   
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Chemical reaction (4)   
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KEGG   REACTION: R04743
Entry
R04743                      Reaction                               
Name
(S)-hydroxydecanoyl-CoA:NAD+ oxidoreductase
Definition
(S)-Hydroxydecanoyl-CoA + NAD+ <=> 3-Oxodecanoyl-CoA + NADH + H+
Equation
C05264 + C00003 <=> C05265 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00029  C05264_C05265
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04743  (S)-Hydroxydecanoyl-CoA + NAD+ <=> 3-Oxodecanoyl-CoA + NADH + H+
    1.1.1.211
     R04743  (S)-Hydroxydecanoyl-CoA + NAD+ <=> 3-Oxodecanoyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04743  (S)-Hydroxydecanoyl-CoA <=> 3-Oxodecanoyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04743  (S)-Hydroxydecanoyl-CoA <=> 3-Oxodecanoyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
Other DBs
RHEA: 31190

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Ontology (2)   
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Pathway (10)   
   KEGG PATHWAY (8)   
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Chemical substance (5)   
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Chemical reaction (5)   
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Gene (6312)   
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   KEGG GENES (6307)   
All databases (6334)   

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KEGG   REACTION: R04745
Entry
R04745                      Reaction                               
Name
(S)-hydroxyoctanoyl-CoA:NAD+ oxidoreductase
Definition
(S)-3-Hydroxyoctanoyl-CoA + NAD+ <=> 3-Oxooctanoyl-CoA + NADH + H+
Equation
C05266 + C00003 <=> C05267 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00029  C05266_C05267
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04745  (S)-3-Hydroxyoctanoyl-CoA + NAD+ <=> 3-Oxooctanoyl-CoA + NADH + H+
    1.1.1.211
     R04745  (S)-3-Hydroxyoctanoyl-CoA + NAD+ <=> 3-Oxooctanoyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04745  (S)-3-Hydroxyoctanoyl-CoA <=> 3-Oxooctanoyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04745  (S)-3-Hydroxyoctanoyl-CoA <=> 3-Oxooctanoyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
Other DBs
RHEA: 31198

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Ontology (2)   
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Pathway (10)   
   KEGG PATHWAY (8)   
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Chemical substance (5)   
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Chemical reaction (5)   
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Gene (10745)   
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KEGG   REACTION: R04748
Entry
R04748                      Reaction                               
Name
(S)-hydroxyhexanoyl-CoA:NAD+ oxidoreductase
Definition
(S)-Hydroxyhexanoyl-CoA + NAD+ <=> 3-Oxohexanoyl-CoA + NADH + H+
Equation
C05268 + C00003 <=> C05269 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00029  C05268_C05269
Enzyme
1.1.1.35        1.1.1.211
Pathway
rn00062  Fatty acid elongation
rn00071  Fatty acid degradation
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Module
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35
     R04748  (S)-Hydroxyhexanoyl-CoA + NAD+ <=> 3-Oxohexanoyl-CoA + NADH + H+
    1.1.1.211
     R04748  (S)-Hydroxyhexanoyl-CoA + NAD+ <=> 3-Oxohexanoyl-CoA + NADH + H+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.1.1.35
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04748  (S)-Hydroxyhexanoyl-CoA <=> 3-Oxohexanoyl-CoA
  1.1.1.211
   R01778  (3S)-3-Hydroxyacyl-CoA <=> 3-Oxoacyl-CoA
    R04748  (S)-Hydroxyhexanoyl-CoA <=> 3-Oxohexanoyl-CoA
Orthology
K00022  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07514  enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
K07515  enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K10527  enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35 1.1.1.211]
Other DBs
RHEA: 31146

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Pathway (10)   
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Chemical substance (5)   
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Gene (10745)   
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KEGG   REACTION: R04810
Entry
R04810                      Reaction                               
Name
(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA:NAD+ oxidoreductase
Definition
(24R,25R)-3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA + NAD+ <=> 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA + NADH + H+
Equation
C05448 + C00003 <=> C05449 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00089  C05448_C05449
Enzyme
1.1.1.-
Pathway
rn00120  Primary bile acid biosynthesis
rn01100  Metabolic pathways
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
M00862  beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R04810  (24R,25R)-3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA + NAD+ <=> 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA + NADH + H+
Orthology
K12405  (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.107 4.2.1.119]
Reference
1  [PMID:12543708]
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712
Reference
2  [PMID:11146090]
  Authors
Kurosawa T, Sato M, Nakano H, Fujiwara M, Murai T, Yoshimura T, Hashimoto T.
  Title
Conjugation reactions catalyzed by bifunctional proteins related to beta-oxidation in bile acid biosynthesis.
  Journal
Steroids 66:107-14 (2001)
DOI:10.1016/S0039-128X(00)00217-8

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