KEGG   REACTION: R01978Help
Entry
R01978                      Reaction                               

Name
acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
Definition
(S)-3-Hydroxy-3-methylglutaryl-CoA + CoA <=> Acetyl-CoA + H2O + Acetoacetyl-CoA
Equation
Comment
possibly two-step reaction (acetoacetyl-CoA-lyase, thioester-hydrolysing)
Reaction class
RC00004  C00010_C00024
RC00503  C00332_C00356
Enzyme
Pathway
rn00072  Synthesis and degradation of ketone bodies
rn00280  Valine, leucine and isoleucine degradation
rn00650  Butanoate metabolism
rn00900  Terpenoid backbone biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01130  Biosynthesis of antibiotics
Module
M00088  Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
M00095  C5 isoprenoid biosynthesis, mevalonate pathway
M00849  C5 isoprenoid biosynthesis, mevalonate pathway, archaea
Orthology
K01641  hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
Other DBs
RHEA: 10191

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