LOCUS NC_001138 270161 bp DNA linear CON 15-SEP-2023
DEFINITION Saccharomyces cerevisiae S288C chromosome VI, complete sequence.
ACCESSION NC_001138
VERSION NC_001138.5
DBLINK BioProject: PRJNA128
Assembly: GCF_000146045.2
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (bases 1 to 270161)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (bases 1 to 270161)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 3 (bases 1 to 270161)
AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M.,
Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al.
TITLE Analysis of the nucleotide sequence of chromosome VI from
Saccharomyces cerevisiae
JOURNAL Nat. Genet. 10 (3), 261-268 (1995)
PUBMED 7670463
REFERENCE 4 (bases 1 to 270161)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (14-SEP-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (bases 1 to 270161)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (bases 1 to 270161)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 7 (bases 1 to 270161)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 8 (bases 1 to 270161)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to BK006940.
On Apr 26, 2011 this sequence version replaced NC_001138.4.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..270161
/organism="Saccharomyces cerevisiae S288C"
/mol_type="genomic DNA"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="VI"
telomere complement(1..5530)
/note="TEL06L; Telomeric region on the left arm of
Chromosome VI; composed of an X element core sequence, X
element combinatorial repeats, a stretch of telomeric
repeats, and a short Y' element"
/db_xref="SGD:S000028882"
gene <53..>535
/locus_tag="YFL068W"
/db_xref="GeneID:850476"
mRNA <53..>535
/locus_tag="YFL068W"
/product="uncharacterized protein"
/transcript_id="NM_001179899.1"
/db_xref="GeneID:850476"
CDS 53..535
/locus_tag="YFL068W"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/note="hypothetical protein; SWAT-GFP and mCherry fusion
proteins localize to the cytosol"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116587.1"
/db_xref="GeneID:850476"
/db_xref="SGD:S000001826"
/translation="MMPAKLQLDVLRTLQSSARHGTQTLKNSNFLERFHKDRIVFCLP
FFPALFLVPVQKVLQHLCLRFTQVAPYFIIQLFDLPSRHAENLAPLLASCRIQYTNCF
SSSSNGQVPSIISLYLRVDLSPFYAKKFQIPYRVPMIWLDVFQVFFVFLVISQHSLHS
"
gene <836..>1363
/locus_tag="YFL067W"
/db_xref="GeneID:850477"
mRNA <836..>1363
/locus_tag="YFL067W"
/product="uncharacterized protein"
/transcript_id="NM_001179900.1"
/db_xref="GeneID:850477"
CDS 836..1363
/locus_tag="YFL067W"
/note="hypothetical protein; down-regulated at low calcium
levels; mCherry fusion protein localizes to the vacuole"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116588.1"
/db_xref="GeneID:850477"
/db_xref="SGD:S000001827"
/translation="MESIILSIAIFIGVLLGTSVGAGSGSSISPDVDAGSGSRTSPDV
DAGSGSRISAGVGTFSGSSTSPDVDAGSGSSTSPDVGAGSGSSISAGVGSRIGTGIGS
RIGTGIGTGIGSRISTSIGSRISPDVGTSSGNRISTGVSTGISTTMNARVAVLITAAI
LSAPVTAIALLEARR"
gene complement(<1437..>2615)
/locus_tag="YFL066C"
/db_xref="GeneID:850478"
mRNA complement(<1437..>2615)
/locus_tag="YFL066C"
/product="Y' element ATP-dependent helicase"
/transcript_id="NM_001179901.1"
/db_xref="GeneID:850478"
CDS complement(1437..2615)
/locus_tag="YFL066C"
/EC_number="3.6.4.12"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762]"
/note="Helicase-like protein encoded within the telomeric
Y' element; induced by treatment with 8-methoxypsoralen
and UVA irradiation; SWAT-GFP and mCherry fusion proteins
localize to the nucleus"
/codon_start=1
/product="Y' element ATP-dependent helicase"
/protein_id="NP_116589.1"
/db_xref="GeneID:850478"
/db_xref="SGD:S000001828"
/translation="MADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPY
TVLLANCMIRLGRRGCLNVAPVRNFIEEGYDGVTDLYVGIYDDLASTNFTDRIAAWEN
IVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEA
VADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHK
IWKKVESQPEEALKLLLALFEIEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKL
GAAEKVSRTKEFVTDGSMQVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRL
RDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCVC
"
gene complement(<3030..>3338)
/locus_tag="YFL065C"
/db_xref="GeneID:850479"
mRNA complement(<3030..>3338)
/locus_tag="YFL065C"
/product="uncharacterized protein"
/transcript_id="NM_001179902.1"
/db_xref="GeneID:850479"
CDS complement(3030..3338)
/locus_tag="YFL065C"
/note="hypothetical protein; induced by treatment with
8-methoxypsoralen and UVA irradiation"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116590.1"
/db_xref="GeneID:850479"
/db_xref="SGD:S000001829"
/translation="MRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPHMFLLLHVDELSI
FSAYQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRLGDVLRVCCPS
"
gene complement(<3322..>3846)
/locus_tag="YFL064C"
/db_xref="GeneID:850480"
mRNA complement(<3322..>3846)
/locus_tag="YFL064C"
/product="uncharacterized protein"
/transcript_id="NM_001179903.1"
/db_xref="GeneID:850480"
CDS complement(3322..3846)
/locus_tag="YFL064C"
/note="hypothetical protein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116591.1"
/db_xref="GeneID:850480"
/db_xref="SGD:S000001830"
/translation="MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVR
SFYEDEKSGLIKVVKFRTGAMNRKRSFEKIVISVMVGKNVQKFLTFVEDEPDFQGGPI
PSKYLIPKKINLMVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFPCPGTLSRNS
ECQAERQLYDAYFH"
rep_origin 5426..5529
/note="ARS600; Subtelomeric Autonomously Replicating
Sequence; originally published as ARS120"
/db_xref="SGD:S000029653"
gene <6426..>7565
/gene="COS4"
/locus_tag="YFL062W"
/db_xref="GeneID:850482"
mRNA <6426..>7565
/gene="COS4"
/locus_tag="YFL062W"
/product="Cos4p"
/transcript_id="NM_001179905.1"
/db_xref="GeneID:850482"
CDS 6426..7565
/gene="COS4"
/locus_tag="YFL062W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:14562095|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005768 endosome
[PMID:25942624]"
/note="Endosomal protein involved in turnover of plasma
membrane proteins; member of the DUP380 subfamily of
conserved, often subtelomeric COS genes; required for the
multivesicular vesicle body sorting pathway that
internalizes plasma membrane proteins for degradation; Cos
proteins provide ubiquitin in trans for nonubiquitinated
cargo proteins"
/codon_start=1
/product="Cos4p"
/protein_id="NP_116593.1"
/db_xref="GeneID:850482"
/db_xref="SGD:S000001832"
/translation="MKENELKNEKSVDVLSFKQLESQKIVLPQDLFRSSFTWFCYEIY
KSLAFRIWMLLWLPLSVWWKLSNNWIYPLMVSLLVLFWGPVFVLVIFRLSRKRSLSKQ
LTQFCKEITKSTPSSDPHDWEVVAANLNSYLYENKAWNIRYFFFNAMGCQEAFRTTLL
EPFSLKKDEAAKVKSFKDSVPYIEEALGVYFREVEKQWKLFNSEKSWSPVGLEDAKLP
KEAYRFKLTWFLKRISNIFMLIPFLNFLCCIYVSRGMCLLLRTLYLGWILFMLVQGFQ
NIRVLIMSMEHKMQFLSTIINEQESGANGWDEIARKMNRYLFEKKVWKNEEFFFDGID
CEWFFSHFFYRVLSAKKSMRALSLNVELWPYIKEAQLSCSEESLA"
gene <9545..>10222
/gene="DDI3"
/locus_tag="YFL061W"
/gene_synonym="DDI2"
/db_xref="GeneID:850483"
mRNA <9545..>10222
/gene="DDI3"
/locus_tag="YFL061W"
/gene_synonym="DDI2"
/product="cyanamide hydratase"
/transcript_id="NM_001179906.1"
/db_xref="GeneID:850483"
CDS 9545..10222
/gene="DDI3"
/locus_tag="YFL061W"
/gene_synonym="DDI2"
/EC_number="4.2.1.69"
/experiment="EXISTENCE:direct assay:GO:0018820 cyanamide
hydratase activity [PMID:25847245]"
/experiment="EXISTENCE:mutant phenotype:GO:0018890
cyanamide metabolic process [PMID:25847245]"
/note="Cyanamide hydratase that detoxifies cyanamide;
member of the HD domain metalloprotein superfamily;
expression is induced over 100-fold by cyanamide and by
SN2-type DNA alkylating agents such as MMS and DMA;
induction decreased in rad6 and rad18 mutants; gene and
protein are identical to DDI2 and Ddi2p"
/codon_start=1
/product="cyanamide hydratase"
/protein_id="NP_116594.1"
/db_xref="GeneID:850483"
/db_xref="SGD:S000001833"
/translation="MSQYGFVRVPREVEKAIPVVNAPRPRAVVPPPNSETARLVREYA
AKELTAPVLNHSLRVFQYSVAIIRDQFPAWDLDQEVLYVTCLLHDIATTDKNMRATKM
SFEYYGGILSRELVFNATGGNQDYADAVTEAIIRHQDLTGTGYITTLGLILQIATTLD
NVGSNTDLIHIDTVSAINEQFPRLHWLSCFATVVDTENSRKPWGHTSSLGDDFSKKVI
CNTFGYN"
gene complement(<10301..>10969)
/gene="SNO3"
/locus_tag="YFL060C"
/db_xref="GeneID:850484"
mRNA complement(<10301..>10969)
/gene="SNO3"
/locus_tag="YFL060C"
/product="putative pyridoxal 5'-phosphate synthase"
/transcript_id="NM_001179907.1"
/db_xref="GeneID:850484"
CDS complement(10301..10969)
/gene="SNO3"
/locus_tag="YFL060C"
/EC_number="3.5.1.2"
/EC_number="4.3.3.6"
/experiment="EXISTENCE:direct assay:GO:0008614 pyridoxine
metabolic process [PMID:9791124]"
/note="hypothetical protein; nearly identical to Sno2p;
expression is induced before the diauxic shift and also in
the absence of thiamin"
/codon_start=1
/product="putative pyridoxal 5'-phosphate synthase"
/protein_id="NP_116595.1"
/db_xref="GeneID:850484"
/db_xref="SGD:S000001834"
/translation="MTVVIGVLALQGAFIEHVRHVEKCIVENRDFYEKKLSVMTVKDK
NQLAQCDALIIPGGESTAMSLIAERTGFYDDLYAFVHNPSKVTWGTCAGLIYISQQLS
NEAKLVKTLNLLKVKVKRNAFGRQAQSSTRICDFSNFIPHCNDFPATFIRAPVIEEVL
DPEHVQVLYKLDGKDNGGQELIVAAKQKNNILATSFHPELAENDIRFHDWFIREFVLK
NYSK"
gene <11363..>12259
/gene="SNZ3"
/locus_tag="YFL059W"
/db_xref="GeneID:850485"
mRNA <11363..>12259
/gene="SNZ3"
/locus_tag="YFL059W"
/product="pyridoxine biosynthesis protein SNZ3"
/transcript_id="NM_001179908.1"
/db_xref="GeneID:850485"
CDS 11363..12259
/gene="SNZ3"
/locus_tag="YFL059W"
/EC_number="4.3.3.6"
/experiment="EXISTENCE:direct assay:GO:0036381 pyridoxal
5'-phosphate synthase (glutamine hydrolysing) activity
[PMID:30498136]"
/experiment="EXISTENCE:genetic interaction:GO:0008615
pyridoxine biosynthetic process [PMID:30498136]"
/experiment="EXISTENCE:genetic interaction:GO:0009228
thiamine biosynthetic process [PMID:30498136]"
/note="Pyridoxal-5'-phosphate synthase; involved in
thiamine and pyridoxine biosynthesis; member of a
stationary phase-induced gene family where transcriptional
induction precedes the diauxic shift; induced in the
absence of thiamine in a Thi2/3p-dependent manner and
repressed in its presence; forms a co-regulated gene pair
with SNO3; paralog of SNZ1 and SNZ2"
/codon_start=1
/product="pyridoxine biosynthesis protein SNZ3"
/protein_id="NP_116596.1"
/db_xref="GeneID:850485"
/db_xref="SGD:S000001835"
/translation="MSEFKVKTGLAQMLKGGVIMDVVTPEQAIIAERAGACAVMALER
IPADMRKSGQVCRMSDPRMIKEIMEAVSIPVMAKVRIGHFVEAQILEELQVDYIDESE
VLTPADWTHHIEKHNFKVPFVCGAKDLGEALRRINEGAAMIRTKGEAGTGDVSEAVKH
ITKIKAEIQQYKENLKTESDFAAKATELRVPVDLLKTTLSEGKLPVVNFAAGGVATPA
DAALLMQLGCEGVFVGSGIFKSSDPEKLACAIVEATTHYDNPAKLLQVSSDLGDLMGG
ISIQSINEAGGKNGARLSEIGW"
gene <12929..>13951
/gene="THI5"
/locus_tag="YFL058W"
/db_xref="GeneID:850486"
mRNA <12929..>13951
/gene="THI5"
/locus_tag="YFL058W"
/product="4-amino-5-hydroxymethyl-2-methylpyrimidine
phosphate synthase"
/transcript_id="NM_001179909.1"
/db_xref="GeneID:850486"
CDS 12929..13951
/gene="THI5"
/locus_tag="YFL058W"
/experiment="EXISTENCE:genetic interaction:GO:0009228
thiamine biosynthetic process [PMID:12777485]"
/note="Protein involved in synthesis of the thiamine
precursor HMP; member of a subtelomeric gene family
including THI5, THI11, THI12, and THI13;
hydroxymethylpyrimidine is also known as HMP"
/codon_start=1
/product="4-amino-5-hydroxymethyl-2-methylpyrimidine
phosphate synthase"
/protein_id="NP_116597.1"
/db_xref="GeneID:850486"
/db_xref="SGD:S000001836"
/translation="MSTDKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDMAILEPTN
PSDVTELIGSGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITED
FQSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEGKIDAGIGI
ECMQQVELEEYLAKQGRPASDAKMLRIDKLACLGCCCFCTVLYICNDEFLKKNPEKVR
KFLKAIKKATDYVLADPVKAWKEYIDFKPQLNNDLSYKQYQRCYAYFSSSLYNVHRDW
KKVTGYGKRLAILPPDYVSNYTNEYLSWPEPEEVSDPLEAQRLMAIHQEKCRQEGTFK
RLALPA"
gene complement(14305..15431)
/gene="AAD6"
/locus_tag="YFL056C"
/gene_synonym="YFL057C"
/note="Putative aryl-alcohol dehydrogenase; involved in
oxidative stress response; similar to P. chrysosporium
aryl-alcohol dehydrogenase; ORFs AAD6/YFL056C and
AAD16/YFL057C are displaced from one another by -1
frameshift; members of the AAD gene family comprise three
pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14)
whose two genes are more related to one another than to
other members of the family; expression induced in cells
treated with the mycotoxin patulin"
/pseudo
/db_xref="GeneID:850488"
/db_xref="SGD:S000001838"
mRNA complement(14305..15431)
/gene="AAD6"
/locus_tag="YFL056C"
/gene_synonym="YFL057C"
/pseudo
/db_xref="GeneID:850488"
/db_xref="SGD:S000001838"
gene <17004..>18680
/gene="AGP3"
/locus_tag="YFL055W"
/db_xref="GeneID:850489"
mRNA <17004..>18680
/gene="AGP3"
/locus_tag="YFL055W"
/product="Agp3p"
/transcript_id="NM_001179912.1"
/db_xref="GeneID:850489"
CDS 17004..18680
/gene="AGP3"
/locus_tag="YFL055W"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0006865 amino acid
transport [PMID:10654085]"
/experiment="EXISTENCE:direct assay:GO:0015171 amino acid
transmembrane transporter activity [PMID:10654085]"
/experiment="EXISTENCE:direct assay:GO:0055085
transmembrane transport [PMID:10654085]"
/experiment="EXISTENCE:mutant phenotype:GO:0006865 amino
acid transport [PMID:14697254]"
/experiment="EXISTENCE:mutant phenotype:GO:0015171 amino
acid transmembrane transporter activity [PMID:14697254]"
/note="Low-affinity amino acid permease; may act to supply
the cell with amino acids as nitrogen source in
nitrogen-poor conditions; transcription is induced under
conditions of sulfur limitation; plays a role in
regulating Ty1 transposition"
/codon_start=1
/product="Agp3p"
/protein_id="NP_116600.1"
/db_xref="GeneID:850489"
/db_xref="SGD:S000001839"
/translation="MAVLNLKRETVDIEETAKKDIKPYFASNVEAVDIDEDPDVSRYD
PQTGVKRALKNRHISLLALGGVIGPGCLVGAGNALNKGGPLALLLGFSIIGIIAFSVM
ESIGEMITLYPSGGGFTTLARRFHSDALPAVCGYAYVVVFFAVLANEYNTLSSILQFW
GPQVPLYGYILIFWFAFEIFQLVGVGLFGETEYWLAWLKIVGLVAYYIFSIVYISGDI
RNRPAFGFHYWNSPGALSHGFKGIAIVFVFCSTFYSGTESVALAATESKNPGKAVPLA
VRQTLWRILVVYIGIAVFYGATVPFDDPNLSASTKVLKSPIAIAISRAGWAGGAHLVN
AFILITCISAINGSLYIGSRTLTHLAHEGLAPKILAWTDRRGVPIPAITVFNALGLIS
LMNVSVGAANAYSYIVNLSGVGVFIVWGVISYTHLRIRKAWVAQGRSIEELPYEALFY
PWTPVLSLAANIFLALIQGWSYFVPFDAGNFVDAYILLPVGILLYIGICVFKSNHFRT
VDLRSINLDEGRRKDMEADLSDQESSLASSETMKDYKSATFFRYLSNIFT"
rep_origin 20702..20900
/note="ARS600.4; Strong autonomously replicating sequence"
/db_xref="SGD:S000178094"
gene complement(<20847..>22787)
/gene="AQY3"
/locus_tag="YFL054C"
/db_xref="GeneID:850490"
mRNA complement(<20847..>22787)
/gene="AQY3"
/locus_tag="YFL054C"
/product="Aqy3p"
/transcript_id="NM_001179913.1"
/db_xref="GeneID:850490"
CDS complement(20847..22787)
/gene="AQY3"
/locus_tag="YFL054C"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0015254
glycerol channel activity [PMID:12832087]"
/experiment="EXISTENCE:mutant phenotype:GO:0055085
transmembrane transport [PMID:12832087]"
/note="Putative channel-like protein; similar to Fps1p;
mediates passive diffusion of glycerol in the presence of
ethanol"
/codon_start=1
/product="Aqy3p"
/protein_id="NP_116601.1"
/db_xref="GeneID:850490"
/db_xref="SGD:S000001840"
/translation="MSYESGRSSSSSESTRPPTLKEEPNGKIAWEESVKKSRENNEND
STLLRRKLGETRKAIETGGSSRNKLSALTPLKKVVDERKDSVQPQVPSMGFTYSLPNL
KTLNSFSDAEQARIMQDYLSRGVNQGNSNNYVDPLYRQLNPTMGSSRNRPVWSLNQPL
PHVLDRGLAAKMIQKNMDARSRASSRRGSTDISRGGSTTSVKDWKRLLRGAAPGKKLG
DIEAQTQRDNTVGADVKPTKLEPENPQKPSNTHIENVSRKKKRTSHNVNFSLGDESYA
SSIADAESRKLKNMQTLDGSTPVYTKLPEELIEEENKSTSALDGNEIGASEDEDADIM
TFPNFWAKIRYHMREPFAEFLGTLVLVIFGVGGNLQATVTKGSGGSYESLSFAWGFGC
MLGVYVAGGISGGHINPAVTISMAIFRKFPWKKVPVYIVAQIIGAYFGGAMAYGYFWS
SITEFEGGPHIRTTATGACLFTDPKSYVTWRNAFFDEFIGASILVGCLMALLDDSNAP
PGNGMTALIIGFLVAAIGMALGYQTSFTINPARDLGPRIFASMIGYGPHAFHLTHWWW
TWGAWGGPIAGGIAGALIYDIFIFTGCESPVNYPDNGYIENRVGKLLHAEFHQNDGTV
SDESGVNSNSNTGSKKSVPTSS"
gene <23423..>25198
/gene="DAK2"
/locus_tag="YFL053W"
/db_xref="GeneID:850491"
mRNA <23423..>25198
/gene="DAK2"
/locus_tag="YFL053W"
/product="dihydroxyacetone kinase"
/transcript_id="NM_001179914.1"
/db_xref="GeneID:850491"
CDS 23423..25198
/gene="DAK2"
/locus_tag="YFL053W"
/EC_number="2.7.1.28"
/EC_number="2.7.1.29"
/experiment="EXISTENCE:genetic interaction:GO:0004371
glycerone kinase activity [PMID:12401799]"
/experiment="EXISTENCE:genetic interaction:GO:0061610
glycerol to glycerone phosphate metabolic process
[PMID:22979944]"
/experiment="EXISTENCE:mutant phenotype:GO:0004371
glycerone kinase activity [PMID:12401799]"
/note="Dihydroxyacetone kinase; required for
detoxification of dihydroxyacetone (DHA); involved in
stress adaptation"
/codon_start=1
/product="dihydroxyacetone kinase"
/protein_id="NP_116602.1"
/db_xref="GeneID:850491"
/db_xref="SGD:S000001841"
/translation="MSHKQFKSDGNIVTPYLLGLARSNPGLTVIKHDRVVFRTASAPN
SGNPPKVSLVSGGGSGHEPTHAGFVGEGALDAIAAGAIFASPSTKQIYSAIKAVESPK
GTLIIVKNYTGDIIHFGLAAERAKAAGMKVELVAVGDDVSVGKKKGSLVGRRGLGATV
LVHKIAGAAASHGLELAEVAEVAQSVVDNSVTIAASLDHCTVPGHKPEAILGENEYEI
GMGIHNESGTYKSSPLPSISELVSQMLPLLLDEDEDRSYVKFEPKEDVVLMVNNMGGM
SNLELGYAAEVISEQLIDKYQIVPKRTITGAFITALNGPGFGITLMNASKAGGDILKY
FDYPTTASGWNQMYHSAKDWEVLAKGQVPTAPSLKTLRNEKGSGVKADYDTFAKILLA
GIAKINEVEPKVTWYDTIAGDGDCGTTLVSGGEALEEAIKNHTLRLEDAALGIEDIAY
MVEDSMGGTSGGLYSIYLSALAQGVRDSGDKELTAETFKKASNVALDALYKYTRARPG
YRTLIDALQPFVEALKAGKGPRAAAQAAYDGAEKTRKMDALVGRASYVAKEELRKLDS
EGGLPDPGAVGLAALLDGFVTAAGY"
gene <28232..>29629
/gene="ZNF1"
/locus_tag="YFL052W"
/db_xref="GeneID:850492"
mRNA <28232..>29629
/gene="ZNF1"
/locus_tag="YFL052W"
/product="DNA-binding domain containing protein"
/transcript_id="NM_001179915.1"
/db_xref="GeneID:850492"
CDS 28232..29629
/gene="ZNF1"
/locus_tag="YFL052W"
/experiment="EXISTENCE:curator inference:GO:0005634
nucleus [PMID:25673751]"
/experiment="EXISTENCE:direct assay:GO:0000977 RNA
polymerase II transcription regulatory region
sequence-specific DNA binding [PMID:25673751]"
/experiment="EXISTENCE:mutant phenotype:GO:0001228
DNA-binding transcription activator activity, RNA
polymerase II-specific [PMID:25673751]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:25673751]"
/note="Zinc cluster transcription factor that regulates
respiratory growth; binds to promoters of genes involved
in respiration, gluconeogenesis, and the glyoxylate shunt;
required for normal carbon source utilization and
adaptation to pH, osmotic and ethanol stress especially
during non-fermentative metabolism"
/codon_start=1
/product="DNA-binding domain containing protein"
/protein_id="NP_116603.1"
/db_xref="GeneID:850492"
/db_xref="SGD:S000001842"
/translation="MARNRQACDCCCIRRVKCDRKKPCKCCLQHNLQCTYLRPLKKRG
PKPVKVRNLKKVDDVQVFSKSSSGGIMKVPKALIDQCLRLYNDKLYVIWPLLCYDDLY
ELLEKRYDETCVYWFLVSLSAATLSDLQTEIESEGGVTFTGIQLSSFCMSSRQEFDDF
NGSDIFKIMTYYCLNRCYAQMSNSRTSYRLSCEAVGLIKLAGFHREETLKLLPFDEQQ
LGRKVYYLLLLTERYFSVYTHCATSLDTTIAPPQPENVTDPRLSLDSFLEMIRVFTVP
GKCFFDALATDSANVTCTEDSLKKIWRELHTVPLEIEPWSYGYVDISFSRHWIRTLAW
KLVLQISGMRISFLSNSKNTHIPVEIARDMLEDTFLIPKNLYAVHGPGISVKALEIAD
ALVDVVNQYDQNAESEAWNFLFDISKFVFSLKHCDSTLVDKFTTKCQCALITLPLSNP
LESTDGSKEDVDALP"
gene complement(<30058..>30540)
/locus_tag="YFL051C"
/db_xref="GeneID:850493"
mRNA complement(<30058..>30540)
/locus_tag="YFL051C"
/product="uncharacterized protein"
/transcript_id="NM_001179916.1"
/db_xref="GeneID:850493"
CDS complement(30058..30540)
/locus_tag="YFL051C"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/note="hypothetical protein; SWAT-GFP fusion protein
localizes to the cell periphery while mCherry fusion
protein localizes to both the cell periphery and vacuole;
YFL051C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116576.1"
/db_xref="GeneID:850493"
/db_xref="SGD:S000001843"
/translation="MSIPHSVFSALLVFVALATTTLASTEACLPTNKREDGMNINFYE
YTIGDQTTYLEPEYMGYEYSNTKKLGSVSGQTNLSIYYSPPCESTPTCVTYAVLKRDE
DGYDPCGPLYETKKRDTEYCDPNTAYWSSDLFGFYTTPTNVTVEMTGYLIWSMGNRRR
"
rep_origin 32473..32995
/note="ARS601; Autonomously replicating sequence on
Chromosome VI; overlaps ARS602, ARS601/ARS602 together
appear to be activated during the second half of S phase
in
32% of cell cycles"
/db_xref="SGD:S000007633"
rep_origin 32667..33247
/note="ARS602; Autonomously replicating sequence on
Chromosome VI; overlaps ARS601, ARS601/ARS602 together
appear to be activated during the second half of S phase
in
32% of cell cycles"
/db_xref="SGD:S000007634"
gene complement(<33272..>35848)
/gene="ALR2"
/locus_tag="YFL050C"
/db_xref="GeneID:850494"
mRNA complement(<33272..>35848)
/gene="ALR2"
/locus_tag="YFL050C"
/product="putative Mg(2+) transporter ALR2"
/transcript_id="NM_001179917.1"
/db_xref="GeneID:850494"
CDS complement(33272..35848)
/gene="ALR2"
/locus_tag="YFL050C"
/experiment="EXISTENCE:direct assay:GO:0015693 magnesium
ion transport [PMID:12167543]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma
membrane [PMID:9430719]"
/experiment="EXISTENCE:mutant phenotype:GO:0006812
monoatomic cation transport [PMID:9430719]"
/experiment="EXISTENCE:mutant phenotype:GO:0022890
inorganic cation transmembrane transporter activity
[PMID:9430719]"
/experiment="EXISTENCE:mutant phenotype:GO:0055085
transmembrane transport [PMID:9430719]"
/note="Probable Mg(2+) transporter; overexpression confers
increased tolerance to Al(3+) and Ga(3+) ions; plays a
role in regulating Ty1 transposition"
/codon_start=1
/product="putative Mg(2+) transporter ALR2"
/protein_id="NP_116604.1"
/db_xref="GeneID:850494"
/db_xref="SGD:S000001844"
/translation="MSSLSTSFDSSSDLPRSKSVDNTAASMKTGKYPKLENYRQYSDA
QPIRHEALALKVDETKDSRHKFSSSNGENSGVENGGYVEKTNISTSGRMDFEGEAEAE
AVKRYQLRSFALLSSNARPSRLAKSETHQKQIHVESIAPSLPKNAALERGHDTALPAG
TSSNRCNLEASSSARTFTSARKASLVSAIFETSAESEHGTHPKQAKLKRRTYSTISTH
SSVNPTTLLTRTASQKSDMGNDTRRIKPLRMDSRVSFHSEISQASRDSQETEEDVCFP
MFRLLHTRVNGVDFDELEEYAQISNAERNLSLANHQRHSERTYNHTDQDTGFTNSAST
SGSSAALKYTPEISRTLEKNCSVNEMYVSENNESVREDDKPDLHPDVTFGRNKIEGEK
EGNDSSYSRAYYTLQNTEYQIPSRFSFFRSESDETVHASDIPSLISEGQTFYELFKGG
DPTWWLDCSCPTDDEMRCIAKTFGIHPLTAEDIRMQETREKVELFKSYYFVCFHTFEN
DKESENYLEPINVYIVVFRSGVLTFHFDPISHCANVRRRVRQLRDYVSVNSDWLCYAL
IDDITDSFAPVIQSIEYEADSIDDSVFMTRDMDFAAMLQRIGESRRKTMTLMRLLSGK
ADVIKMFAKRCQDETNGIGPVLKSQTNMVNLQAEQENVNQNNSNNQISLSNSYMQTTS
QPRGDIALYLGDIQDHLLTMFQNLLAYEKIFSRSHANYLAQLQVESFNSNNKVTEMLG
KVTMLGTMLVPLNVITGLFGMNVKVPGRNGSIAWWYGILGVLLLLAVISWFLASYWIK
KIDPPATLNEAAGSGAKSVISSFLPKRDKRFNDDSKNGNARVGVRRKSTVSLPSRYSR
YN"
gene <36803..>38674
/gene="SWP82"
/locus_tag="YFL049W"
/db_xref="GeneID:850495"
mRNA <36803..>38674
/gene="SWP82"
/locus_tag="YFL049W"
/product="Swp82p"
/transcript_id="NM_001179918.1"
/db_xref="GeneID:850495"
CDS 36803..38674
/gene="SWP82"
/locus_tag="YFL049W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0006338 chromatin
remodeling [PMID:16204215]"
/experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF
complex
[PMID:16464826|PMID:18644858|PMID:8127913|PMID:16204215]"
/note="Member of the SWI/SNF chromatin remodeling complex;
has an as yet unidentified role in the complex; has
identifiable counterparts in closely related yeast
species; abundantly expressed in many growth conditions;
paralog of Npl6p; relocates to the cytosol under hypoxic
conditions"
/codon_start=1
/product="Swp82p"
/protein_id="NP_116605.1"
/db_xref="GeneID:850495"
/db_xref="SGD:S000001845"
/translation="MLGEDEGNTVLEKGNNPSVKQGEVGAVFIVPKILIREHERVILK
QILQILDQDELVQPPLDKFPYKKLELPKYIDELKTRDATNTSYKMIQLDAYGEKKVGS
NGELFGGRHYLFNTFTFTAHMGVLLVLLQDVIKVLYQSNATHDEDEFIVQHDQILVME
TSEEQTKFLAKNGVIPEESKGSFKYITARSAFVEFGASVIAGGQRIVDDYWESLAKKQ
NLSSHQRVFKLSTNLISKISLLRPSFQNNRISNANEISANTNNTCTISTSKFESQYPI
VTEQPSAEIREAYIENFAKGEHISAIVPGQSISGTLELSAQFRVPRYHSKNSFQQALQ
MKAMDIPIGRHEELLAQYESQAPDGSASISLPNHIPSVNPSNKPIKRMLSSILDINVS
SSKNKKSEENEMIKPMNKGQHKNNTSLNINGWKFESLPLKSAENSGKQQYYRGLPLYE
KNTLLERLKQLTPNEIKELEHLHDAVFVNTGLQNVRKVRTKKWKKYWQYKAGIPIGLK
RSQLDEFKNKYLKDVLAQTSVTTNFNEITNTDETITTKRVPNPNFLGNCNIKDFKPPY
IYSHVNKVPQNVAGDKTAVKLDTEVKNTNANPVVATDPVAAKPDNLANFSNEVAMNN"
gene complement(<38843..>40180)
/gene="EMP47"
/locus_tag="YFL048C"
/db_xref="GeneID:850496"
mRNA complement(<38843..>40180)
/gene="EMP47"
/locus_tag="YFL048C"
/product="Emp47p"
/transcript_id="NM_001179919.1"
/db_xref="GeneID:850496"
CDS complement(38843..40180)
/gene="EMP47"
/locus_tag="YFL048C"
/experiment="EXISTENCE:direct assay:GO:0000139 Golgi
membrane [PMID:12857885]"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:12857885]"
/experiment="EXISTENCE:direct assay:GO:0030134
COPII-coated ER to Golgi transport vesicle
[PMID:11157978]"
/experiment="EXISTENCE:direct assay:GO:0097367
carbohydrate derivative binding [PMID:16439369]"
/experiment="EXISTENCE:genetic interaction:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:12857885]"
/note="Integral membrane component of ER-derived
COPII-coated vesicles; functions in ER to Golgi transport;
forms a complex with Ssp120p that may function in
trafficking plasma membrane glycoproteins through early
secretory pathway; EMP47 has a paralog, EMP46, that arose
from the whole genome duplication"
/codon_start=1
/product="Emp47p"
/protein_id="NP_116606.1"
/db_xref="GeneID:850496"
/db_xref="SGD:S000001846"
/translation="MMMLITMKSTVLLSVFTVLATWAGLLEAHPLGDTSDASKLSSDY
SLPDLINARKVPNNWQTGEQASLEEGRIVLTSKQNSKGSLWLKQGFDLKDSFTMEWTF
RSVGYSGQTDGGISFWFVQDSNVPRDKQLYNGPVNYDGLQLLVDNNGPLGPTLRGQLN
DGQKPVDKTKIYDQSFASCLMGYQDSSVPSTIRVTYDLEDDNLLKVQVDNKVCFQTRK
VRFPSGSYRIGVTAQNGAVNNNAESFEIFKMQFFNGVIEDSLIPNVNAMGQPKLITKY
IDQQTGKEKLIEKTAFDADKDKITNYELYKKLDRVEGKILANDINALETKLNDVIKVQ
QELLSFMTTITKQLSSKPPANNEKGTSTDDAIAEDKENFKDFLSINQKLEKVLVEQEK
YREATKRHGQDGPQVDEIARKLMIWLLPLIFIMLVMAYYTFRIRQEIIKTKLL"
gene <40421..>42565
/gene="RGD2"
/locus_tag="YFL047W"
/db_xref="GeneID:850497"
mRNA <40421..>42565
/gene="RGD2"
/locus_tag="YFL047W"
/product="GTPase-activating protein RGD2"
/transcript_id="NM_001179920.1"
/db_xref="GeneID:850497"
CDS 40421..42565
/gene="RGD2"
/locus_tag="YFL047W"
/experiment="EXISTENCE:direct assay:GO:0005096 GTPase
activator activity [PMID:11591390]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005934 cellular
bud tip [PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:physical interaction:GO:0007264
small GTPase mediated signal transduction [PMID:11591390]"
/note="GTPase-activating protein (RhoGAP) for Cdc42p and
Rho5p; relocalizes from bud neck to cytoplasm upon DNA
replication stress"
/codon_start=1
/product="GTPase-activating protein RGD2"
/protein_id="NP_428268.1"
/db_xref="GeneID:850497"
/db_xref="SGD:S000001847"
/translation="MLSFCDYFWSEDLVSGLDVLFDRLYHGCEQCDLFIQLFASRMQF
EVSHGRQLFGIEAGMDNLKAVQEDEDEGVTVSRALRGILQEMSQEGTHHLTIASNIES
LVLQPFSKWCIEHRERIQYSEKTLLTNVNNFRKSKKYVGKLEKEYFNKCRQLEEFKRT
HFNEDELANAMKSLKIQNKYEEDVAREKDHRFFNRIAGIDFDYKTMKETLQLLLTKLP
KTDYKLPLISYSLSNTNNGGEITKFLLDHMSLKDIDQAETFGQDLLNLGFLKYCNGVG
NTFVNSKKFQYQWKNTAYMFANVPMPGSEEPTTGESLISRFNNWDGSSAKEIIQSKIG
NDQGAAKIQAPHISDNERTLFRMMDALAASDKKYYQECFKMDALRCSVEELLIDHLSF
MEKCESDRLNAIKKATLDFCSTLGNKISSLRLCIDKMLTLENDIDPTADLLQLLVKYK
TGSFKPQAIVYNNYYNPGSFQNFGVDLETRCRLDKKVVPLIISSIFSYMDKIYPDLPN
DKVRTSIWTDSVKLSLTHQLRNLLNKQQFHNEGEIFDILSTSKLEPSTIASVVKIYLL
ELPDPLIPNDVSDILRVLYLDYPPLVETALQNSTSSPENQQDDDNEEGFDTKRIRGLY
TTLSSLSKPHIATLDAITTHFYRLIKILKMGENGNEVADEFTVSISQEFANCIIQSKI
TDDNEIGFKIFYDLLTHKKQIFHELKRQNSKN"
gene <42815..>43438
/gene="FMP32"
/locus_tag="YFL046W"
/gene_synonym="PUT6"
/db_xref="GeneID:850498"
mRNA <42815..>43438
/gene="FMP32"
/locus_tag="YFL046W"
/gene_synonym="PUT6"
/product="Fmp32p"
/transcript_id="NM_001179921.1"
/db_xref="GeneID:850498"
CDS 42815..43438
/gene="FMP32"
/locus_tag="YFL046W"
/gene_synonym="PUT6"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:12514182|PMID:14576278|PMID:16823961|PMID:24769239|P
MID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005743
mitochondrial inner membrane [PMID:32978391]"
/experiment="EXISTENCE:mutant phenotype:GO:0033617
mitochondrial cytochrome c oxidase assembly
[PMID:25565209]"
/experiment="EXISTENCE:mutant phenotype:GO:2000214
regulation of proline metabolic process [PMID:32978391]"
/note="Regulator of mitochondrial proline metabolism;
tethered with Put7p to inner mitochondrial membrane in
large hetero-oligomeric complex, abundance of which is
regulated by proline; involved in mitochondrial proline
homeostasis and cellular redox balance; null exhibits
pronounced defect in proline utilization, and can be
functionally complemented by expression of human homolog
MCUR1"
/codon_start=1
/product="Fmp32p"
/protein_id="NP_116608.1"
/db_xref="GeneID:850498"
/db_xref="SGD:S000001848"
/translation="MLKRIVGLPARRCFHRTSFLLGSDFETVHIPNTNHFKDLLIENG
KFQEDQATTIVEIMTDAIRGGVNHVSQDLAKREKLTQLSYQQRVDFAKLRDQLLSADR
SEFHNIQNEYESVKNDLEKLRNKLREEITKTNAGFKLDLSLEKGRIREESSHHDLQIK
EIDTKIEQEVTNMKMQIDSVKTQVMQWLIGVCTGTFALVLAYMRLLT"
gene complement(<43628..>44392)
/gene="SEC53"
/locus_tag="YFL045C"
/gene_synonym="ALG4"
/db_xref="GeneID:850499"
mRNA complement(<43628..>44392)
/gene="SEC53"
/locus_tag="YFL045C"
/gene_synonym="ALG4"
/product="phosphomannomutase SEC53"
/transcript_id="NM_001179922.1"
/db_xref="GeneID:850499"
CDS complement(43628..44392)
/gene="SEC53"
/locus_tag="YFL045C"
/gene_synonym="ALG4"
/EC_number="5.4.2.8"
/experiment="EXISTENCE:direct assay:GO:0004615
phosphomannomutase activity [PMID:3288631]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:3905826]"
/experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
stress granule [PMID:26777405]"
/note="Phosphomannomutase; involved in synthesis of
GDP-mannose and dolichol-phosphate-mannose; required for
folding and glycosylation of secretory proteins in the ER
lumen; human homolog PMM2 complements yeast mutants"
/codon_start=1
/product="phosphomannomutase SEC53"
/protein_id="NP_116609.1"
/db_xref="GeneID:850499"
/db_xref="SGD:S000001849"
/translation="MSIAEFAYKEKPETLVLFDVDGTLTPARLTVSEEVRKTLAKLRN
KCCIGFVGGSDLSKQLEQLGPNVLDEFDYSFSENGLTAYRLGKELASQSFINWLGEEK
YNKLAVFILRYLSEIDLPKRRGTFLEFRNGMINVSPIGRNASTEERNEFERYDKEHQI
RAKFVEALKKEFPDYGLTFSIGGQISFDVFPAGWDKTYCLQHVEKDGFKEIHFFGDKT
MVGGNDYEIFVDERTIGHSVQSPDDTVKILTELFNL"
gene complement(<44655..>45560)
/gene="OTU1"
/locus_tag="YFL044C"
/db_xref="GeneID:850500"
mRNA complement(<44655..>45560)
/gene="OTU1"
/locus_tag="YFL044C"
/product="ubiquitin-specific protease OTU1"
/transcript_id="NM_001179923.1"
/db_xref="GeneID:850500"
CDS complement(44655..45560)
/gene="OTU1"
/locus_tag="YFL044C"
/EC_number="3.4.19.12"
/experiment="EXISTENCE:direct assay:GO:0004843
cysteine-type deubiquitinase activity [PMID:16427015]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0016579 protein
deubiquitination [PMID:16427015]"
/experiment="EXISTENCE:mutant phenotype:GO:0006355
regulation of DNA-templated transcription [PMID:15755922]"
/note="Deubiquitylation enzyme that binds to the
chaperone-ATPase Cdc48p; may contribute to regulation of
protein degradation by deubiquitylating substrates that
have been ubiquitylated by Ufd2p; member of the Ovarian
Tumor (OTU) family; protein abundance increases in
response to DNA replication stress"
/codon_start=1
/product="ubiquitin-specific protease OTU1"
/protein_id="NP_116610.1"
/db_xref="GeneID:850500"
/db_xref="SGD:S000001850"
/translation="MKLKVTGAGINQVVTLKQDATLNDLIEHINVDVKTMRFGYPPQR
INLQGEDASLGQTQLDELGINSGEKITIESSDSNESFSLPPPQPKPKRVLKSTEMSIG
GSGENVLSVHPVLDDNSCLFHAIAYGIFKQDSVRDLREMVSKEVLNNPVKFNDAILDK
PNKDYAQWILKMESWGGAIEIGIISDALAVAIYVVDIDAVKIEKFNEDKFDNYILILF
NGIHYDSLTMNEFKTVFNKNQPESDDVLTAALQLASNLKQTGYSFNTHKAQIKCNTCQ
MTFVGEREVARHAESTGHVDFGQNR"
gene complement(<45720..>47744)
/gene="LAM5"
/locus_tag="YFL042C"
/gene_synonym="LTC2; YFL043C"
/db_xref="GeneID:850501"
mRNA complement(<45720..>47744)
/gene="LAM5"
/locus_tag="YFL042C"
/gene_synonym="LTC2; YFL043C"
/product="Lam5p"
/transcript_id="NM_001179924.1"
/db_xref="GeneID:850501"
CDS complement(45720..47744)
/gene="LAM5"
/locus_tag="YFL042C"
/gene_synonym="LTC2; YFL043C"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0044233
mitochondria-associated endoplasmic reticulum membrane
[PMID:26001273]"
/experiment="EXISTENCE:direct assay:GO:0071561
nucleus-vacuole junction [PMID:26001273]"
/note="Putative sterol transfer protein; one of six
StART-like domain-containing proteins in yeast that may be
involved in sterol transfer between intracellular
membranes; conserved across eukaryotes; has both GRAM and
StART-like (VASt) domains; localizes to membrane contact
sites throughout the cell, including nucleus-vacuole
junctions and ER-mitochondrial contact sites"
/codon_start=1
/product="Lam5p"
/protein_id="NP_116611.1"
/db_xref="GeneID:850501"
/db_xref="SGD:S000001852"
/translation="MSDVDNWEPVSDNEDSTDSVKQLGPPFEHASNNDNAGDTEAESL
QEVPLNTETNDVRKNLVVITNQSAADEHPTEIKHDQSRTSSTSSFFSGMISSFKSNVP
SPVSRSTTPTSPVSQPSIISHRREPSMGSKRRSSRRISNATIAEIGSPLQQVEKPDEV
KTRLTPSQMKEDNYDHRRFVEERYMDTPYHYASEQRNKDFHETFKSVPKDDRLLDDFN
CGLNRELLYQGKLYITETHLCFNSNVLGWIAKVLIAFEDVTFMEKTSAAGLFPSAISI
ETKMGKTLFNGFISRDAAFGLMKEVWSRTLLQKDMASENINTKAEKSGNGKEIDDAIN
SIDEENNDKDANDNDTNENDDENISTNETTPNSTSSSPDKEKEKAYKLRADSSYQYDG
PIYHHSTSFPAEPMANNEFVLKELPFDCAPGILFEIMFNSEQNEFLLDFLRGQEGSQI
TTIPNFTSIDGSSMTLKREYSYEKALHFPAGPKSTTCYVAEVIKRKDPDTYYEVISSI
RTPNVPSGGSFSTKTRYLIRWNDEITCLLRVSFWVEWTGSSWIKGMVENGCKNGQLEA
AQLMERILSKFIKNNVEECQITISKEEEEQDDKEVKNKLKEVDLEQPREAVVTAPAIA
EQQGLKVTMETWLFLYLIVVVLLLFNLFYIRSIAVSLHQLVKLQLVELKL"
gene <48734..>48925
/locus_tag="YFL041W-A"
/db_xref="GeneID:1466401"
mRNA <48734..>48925
/locus_tag="YFL041W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184549.1"
/db_xref="GeneID:1466401"
CDS 48734..48925
/locus_tag="YFL041W-A"
/note="hypothetical protein; identified by fungal homology
and RT-PCR"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_878071.1"
/db_xref="GeneID:1466401"
/db_xref="SGD:S000028547"
/translation="MKMWGPSQRDSFREITYKVKFKYDDGDYSLAIDLMSRDCINVYE
LITDRLLVDFLSKKLLKLR"
gene <49139..>51007
/gene="FET5"
/locus_tag="YFL041W"
/db_xref="GeneID:850502"
mRNA <49139..>51007
/gene="FET5"
/locus_tag="YFL041W"
/product="ferroxidase FET5"
/transcript_id="NM_001179925.1"
/db_xref="GeneID:850502"
CDS 49139..51007
/gene="FET5"
/locus_tag="YFL041W"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane
[PMID:23836928|PMID:10608875|PMID:24390141]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0045121 membrane
raft [PMID:23836928]"
/experiment="EXISTENCE:genetic interaction:GO:0004322
ferroxidase activity [PMID:9413439]"
/experiment="EXISTENCE:mutant phenotype:GO:0006826 iron
ion transport [PMID:9413439]"
/note="Multicopper oxidase; integral membrane protein with
similarity to Fet3p; targeted to vacuole via AP-3 pathway;
may have role in iron transport"
/codon_start=1
/product="ferroxidase FET5"
/protein_id="NP_116612.1"
/db_xref="GeneID:850502"
/db_xref="SGD:S000001853"
/translation="MLFYSFVWSVLAASVALAKTHKLNYTASWVTANPDGLHEKRMIG
FNGEWPLPDIHVEKGDRVELYLTNGFQDNTATSLHFHGLFQNTSLGNQLQMDGPSMVT
QCPIVPGQTYLYNFTVPEQVGTFWYHAHMGAQYGDGMRGAFIIHDPEEPFEYDHERVI
TLSDHYHENYKTVTKEFLSRYNPTGAEPIPQNILFNNTMNVTLDFTPGETYLFRFLNV
GLFVSQYIILEDHEMSIVEVDGVYVKPNFTDSIYLSAGQRMSVLIKAKDKMPTRNYAM
MQIMDETMLDVVPPELQLNQTIQMRYGHSLPEARALNIEDCDLDRATNDFYLEPLIER
DLLAHYDHQIVMDVRMVNLGDGVKYAFFNNITYVTPKVPTLTTLLTSGKLASDPRIYG
DNINAQLLKHNDIIEVVLNNYDSGRHPFHLHGHNFQIVQKSPGFHVDEAYDESEQDEM
TVPYNESAPLQPFPERPMVRDTVVLEPSGHVVLRFRADNPGVWYFHCHVDWHLQQGLA
SVFIEAPVLLQEREKLNENYLDICKAADIPVVGNAAGHSNDWFDLKGLPRQPEPLPKG
FTTEGYLALIISTIIGVWGLYSIAQYGIGEVIPNDEKVYHTLREILAENEIEVSRG"
gene <51350..>52972
/locus_tag="YFL040W"
/db_xref="GeneID:850503"
mRNA <51350..>52972
/locus_tag="YFL040W"
/product="uncharacterized protein"
/transcript_id="NM_001179926.1"
/db_xref="GeneID:850503"
CDS 51350..52972
/locus_tag="YFL040W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005628 prospore
membrane [PMID:24390141]"
/note="Putative transporter; member of the sugar porter
family; YFL040W is not an essential gene; may have a role
in intracellular sterol transport"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116613.1"
/db_xref="GeneID:850503"
/db_xref="SGD:S000001854"
/translation="MTAMKAIVWRLPKMPKIKITKTYEVTKITAILTLVGFIMGLEVP
SLATFLTNKTFNEYFKYPTPLQQGLLMGSTPLGGIMGCFICCIMNDRFSRIYQFQSGI
IIWNIVTLLNFCIWDILGLLICRMIKGMILGNFSILVASYANEVIPRGKRGSTMSYIQ
LCLTIGILVMHYLCIALSLWDSHFAFRIAWCIGIIPGLLFWMASYALPESYHWLVLHG
KMSEAQEIQHNLAKKFNESQPRDAVPEMSKIELAGDFWIGVNDLDFSKKLPRGSFKPL
ILGMTLQLLVQFSGINIILGYITYICEIVGLEGNVKLFTSSIPYFINMVLSLLPITFI
DYTSRKLITLLGGFPISGLLITIGALFVKYGQDTKPIDGNRSLVWSIGENPFVGGWIL
TLCFLIVGIFAMSLSSIPWVYTNEMLPSRVKVKGFAICVTFGWLGNFILTFLCPVMIE
RLKGTTFIIFGSLTFLISLSVLIWFPETKGMSIEDIDKFFEFESKEGTNLHGEKGIKT
PDSNSNGGSTRSSQEGQLHKPIKLKSDEEMII"
gene complement(<53260..>54696)
/gene="ACT1"
/locus_tag="YFL039C"
/gene_synonym="ABY1; END7"
/db_xref="GeneID:850504"
mRNA complement(join(<53260..54377,54687..>54696))
/gene="ACT1"
/locus_tag="YFL039C"
/gene_synonym="ABY1; END7"
/product="actin"
/transcript_id="NM_001179927.1"
/db_xref="GeneID:850504"
CDS complement(join(53260..54377,54687..54696))
/gene="ACT1"
/locus_tag="YFL039C"
/gene_synonym="ABY1; END7"
/experiment="EXISTENCE:direct assay:GO:0000142 cellular
bud neck contractile ring [PMID:3967297|PMID:8163554]"
/experiment="EXISTENCE:direct assay:GO:0000812 Swr1
complex [PMID:14645854|PMID:14690608|PMID:16299513]"
/experiment="EXISTENCE:direct assay:GO:0005200 structural
constituent of cytoskeleton [PMID:6217414]"
/experiment="EXISTENCE:direct assay:GO:0005884 actin
filament [PMID:6217414]"
/experiment="EXISTENCE:direct assay:GO:0006281 DNA repair
[PMID:16135807]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:8245125]"
/experiment="EXISTENCE:direct assay:GO:0030476 ascospore
wall assembly [PMID:17118118]"
/experiment="EXISTENCE:direct assay:GO:0030479 actin
cortical patch [PMID:3967297|PMID:6365930|PMID:8163554]"
/experiment="EXISTENCE:direct assay:GO:0032432 actin
filament bundle [PMID:3967297|PMID:6365930|PMID:8163554]"
/experiment="EXISTENCE:direct assay:GO:0035267 NuA4
histone acetyltransferase complex
[PMID:10911987|PMID:15485911]"
/experiment="EXISTENCE:genetic interaction:GO:0009306
protein secretion [PMID:10793147]"
/experiment="EXISTENCE:genetic interaction:GO:0030010
establishment of cell polarity [PMID:9864365]"
/experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole
inheritance [PMID:8978821]"
/experiment="EXISTENCE:mutant phenotype:GO:0006897
endocytosis [PMID:8590801]"
/experiment="EXISTENCE:mutant phenotype:GO:0009306 protein
secretion [PMID:10793147]"
/experiment="EXISTENCE:mutant phenotype:GO:1902404 mitotic
actomyosin contractile ring contraction [PMID:9732290]"
/experiment="EXISTENCE:physical interaction:GO:0031011
Ino80 complex [PMID:10952318|PMID:24034245]"
/note="Actin, structural protein in cytoskeleton; involved
in cell polarization, endocytosis, and other cytoskeletal
functions; monomeric actin in the nucleus plays a role in
INO80 chromatin remodeling"
/codon_start=1
/product="actin"
/protein_id="NP_116614.1"
/db_xref="GeneID:850504"
/db_xref="SGD:S000001855"
/translation="MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIM
VGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHP
VLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVT
HVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCY
VALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQ
TTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPE
RKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKCF"
gene complement(<55366..>55986)
/gene="YPT1"
/locus_tag="YFL038C"
/db_xref="GeneID:850505"
mRNA complement(<55366..>55986)
/gene="YPT1"
/locus_tag="YFL038C"
/product="Rab family GTPase YPT1"
/transcript_id="NM_001179928.1"
/db_xref="GeneID:850505"
CDS complement(55366..55986)
/gene="YPT1"
/locus_tag="YFL038C"
/experiment="EXISTENCE:direct assay:GO:0000139 Golgi
membrane [PMID:10747087]"
/experiment="EXISTENCE:direct assay:GO:0000149 SNARE
binding [PMID:18388317]"
/experiment="EXISTENCE:direct assay:GO:0000407 phagophore
assembly site [PMID:20375281]"
/experiment="EXISTENCE:direct assay:GO:0003924 GTPase
activity [PMID:3311726|PMID:9447979]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:10747087]"
/experiment="EXISTENCE:direct assay:GO:0005795 Golgi stack
[PMID:12802060]"
/experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi
network [PMID:26906739]"
/experiment="EXISTENCE:direct assay:GO:0031410 cytoplasmic
vesicle [PMID:23129774]"
/experiment="EXISTENCE:direct assay:GO:0035493 SNARE
complex assembly [PMID:8603910]"
/experiment="EXISTENCE:genetic interaction:GO:0006890
retrograde vesicle-mediated transport, Golgi to
endoplasmic reticulum [PMID:18388317]"
/experiment="EXISTENCE:genetic interaction:GO:0048194
Golgi vesicle budding [PMID:18388317]"
/experiment="EXISTENCE:mutant phenotype:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:15689495|PMID:2504726|PMID:7593181]"
/experiment="EXISTENCE:mutant phenotype:GO:0006890
retrograde vesicle-mediated transport, Golgi to
endoplasmic reticulum [PMID:18388317]"
/experiment="EXISTENCE:mutant phenotype:GO:0016236
macroautophagy [PMID:20375281]"
/experiment="EXISTENCE:mutant phenotype:GO:0032258
cytoplasm to vacuole transport by the Cvt pathway
[PMID:20375281]"
/experiment="EXISTENCE:mutant phenotype:GO:0032456
endocytic recycling [PMID:20059749]"
/experiment="EXISTENCE:mutant phenotype:GO:0034497 protein
localization to phagophore assembly site [PMID:26195667]"
/experiment="EXISTENCE:mutant phenotype:GO:0034498 early
endosome to Golgi transport [PMID:20059749]"
/experiment="EXISTENCE:mutant phenotype:GO:0035494 SNARE
complex disassembly [PMID:9157884]"
/experiment="EXISTENCE:mutant phenotype:GO:0048211 Golgi
vesicle docking [PMID:9545229]"
/experiment="EXISTENCE:mutant phenotype:GO:0061709
reticulophagy [PMID:26181331]"
/experiment="EXISTENCE:mutant phenotype:GO:0090114
COPII-coated vesicle budding [PMID:15689495]"
/experiment="EXISTENCE:mutant phenotype:GO:1900101
regulation of endoplasmic reticulum unfolded protein
response [PMID:22844259]"
/experiment="EXISTENCE:mutant phenotype:GO:1990261
pre-mRNA catabolic process [PMID:22844259]"
/experiment="EXISTENCE:physical interaction:GO:0000149
SNARE binding [PMID:18388317]"
/note="Rab family GTPase; involved in the ER-to-Golgi step
of the secretory pathway; complex formation with the Rab
escort protein Mrs6p is required for prenylation of Ypt1p
by type II protein geranylgeranyltransferase
(Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates the
unfolded protein response (UPR) by promoting the decay of
HAC1 RNA; localizes to the early Golgi, the transitional
Golgi and ER membranes, pre-autophagosomal structures, and
cytoplasmic vesicles"
/codon_start=1
/product="Rab family GTPase YPT1"
/protein_id="NP_116615.1"
/db_xref="GeneID:850505"
/db_xref="SGD:S000001856"
/translation="MNSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVD
FKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESFNGVKMW
LQEIDRYATSTVLKLLVGNKCDLKDKRVVEYDVAKEFADANKMPFLETSALDSTNVED
AFLTMARQIKESMSQQNLNETTQKKEDKGNVNLKGQSLTNTGGGCC"
gene <56336..>57709
/gene="TUB2"
/locus_tag="YFL037W"
/gene_synonym="ARM10; SHE8"
/db_xref="GeneID:850506"
mRNA <56336..>57709
/gene="TUB2"
/locus_tag="YFL037W"
/gene_synonym="ARM10; SHE8"
/product="beta-tubulin"
/transcript_id="NM_001179929.1"
/db_xref="GeneID:850506"
CDS 56336..57709
/gene="TUB2"
/locus_tag="YFL037W"
/gene_synonym="ARM10; SHE8"
/experiment="EXISTENCE:direct assay:GO:0005200 structural
constituent of cytoskeleton [PMID:9488492]"
/experiment="EXISTENCE:direct assay:GO:0045298 tubulin
complex [PMID:9488492]"
/experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic
spindle elongation [PMID:12181356]"
/experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase
activity [PMID:8171338]"
/experiment="EXISTENCE:mutant phenotype:GO:0031122
cytoplasmic microtubule organization
[PMID:8171338|PMID:12181356]"
/experiment="EXISTENCE:mutant phenotype:GO:0090307 mitotic
spindle assembly [PMID:12181356|PMID:7806575]"
/experiment="EXISTENCE:physical interaction:GO:0045298
tubulin complex [PMID:9488492]"
/note="Beta-tubulin; associates with alpha-tubulin (Tub1p
and Tub3p) to form tubulin dimer, which polymerizes to
form microtubules; mutation in human ortholog is
associated with congenital fibrosis of the extraocular
muscles (CFEOM) with polymicrogyria"
/codon_start=1
/product="beta-tubulin"
/protein_id="NP_116616.1"
/db_xref="GeneID:850506"
/db_xref="SGD:S000001857"
/translation="MREIIHISTGQCGNQIGAAFWETICGEHGLDFNGTYHGHDDIQK
ERLNVYFNEASSGKWVPRSINVDLEPGTIDAVRNSAIGNLFRPDNYIFGQSSAGNVWA
KGHYTEGAELVDSVMDVIRREAEGCDSLQGFQITHSLGGGTGSGMGTLLISKIREEFP
DRMMATFSVLPSPKTSDTVVEPYNATLSVHQLVEHSDETFCIDNEALYDICQRTLKLN
QPSYGDLNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLVPFPRLHFFMVGYAPLTAI
GSQSFRSLTVPELTQQMFDAKNMMAAADPRNGRYLTVAAFFRGKVSVKEVEDEMHKVQ
SKNSDYFVEWIPNNVQTAVCSVAPQGLDMAATFIANSTSIQELFKRVGDQFSAMFKRK
AFLHWYTSEGMDELEFSEAESNMNDLVSEYQQYQEATVEDDEEVDENGDFGAPQNQDE
PITENFE"
gene complement(57815..58521)
/gene="RUF21"
/locus_tag="YNCF0001C"
/db_xref="GeneID:9164892"
ncRNA complement(57815..58521)
/ncRNA_class="other"
/gene="RUF21"
/locus_tag="YNCF0001C"
/product="RUF21"
/note="RNA of Unknown Function"
/transcript_id="NR_132172.1"
/db_xref="GeneID:9164892"
/db_xref="SGD:S000130129"
gene <58782..>62837
/gene="RPO41"
/locus_tag="YFL036W"
/db_xref="GeneID:850507"
mRNA <58782..>62837
/gene="RPO41"
/locus_tag="YFL036W"
/product="DNA-directed RNA polymerase"
/transcript_id="NM_001179930.1"
/db_xref="GeneID:850507"
CDS 58782..62837
/gene="RPO41"
/locus_tag="YFL036W"
/EC_number="2.7.7.6"
/experiment="EXISTENCE:direct assay:GO:0003896 DNA primase
activity [PMID:26184436]"
/experiment="EXISTENCE:direct assay:GO:0003899
DNA-directed 5'-3' RNA polymerase activity
[PMID:2426263|PMID:3517858]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:2426263|PMID:3517858]"
/experiment="EXISTENCE:direct assay:GO:0006269 DNA
replication, synthesis of RNA primer [PMID:26184436]"
/experiment="EXISTENCE:direct assay:GO:0006390
mitochondrial transcription [PMID:21911502]"
/experiment="EXISTENCE:direct assay:GO:0034245
mitochondrial DNA-directed RNA polymerase complex
[PMID:7929382]"
/experiment="EXISTENCE:direct assay:GO:0042645
mitochondrial nucleoid [PMID:15692048]"
/experiment="EXISTENCE:mutant phenotype:GO:0000002
mitochondrial genome maintenance [PMID:3517858]"
/experiment="EXISTENCE:mutant phenotype:GO:0006390
mitochondrial transcription [PMID:3517858]"
/note="Mitochondrial RNA polymerase; single subunit enzyme
similar to those of T3 and T7 bacteriophages; requires a
specificity subunit encoded by MTF1 for promoter
recognition; Mtf1p interacts with and stabilizes the
Rpo41p-promoter complex, enhancing DNA bending and melting
to facilitate pre-initiation open complex formation;
Rpo41p also synthesizes RNA primers for mitochondrial DNA
replication"
/codon_start=1
/product="DNA-directed RNA polymerase"
/protein_id="NP_116617.1"
/db_xref="GeneID:850507"
/db_xref="SGD:S000001858"
/translation="MLRPAYKSLVKTSLLQRRLISSKGSKLFKPSPDSTSTILISEDP
LVTGSSPTSSTTSGIISSNDFPLFNKNRKDAKSSISYQWKNPSELEFDPFNKSHASAV
TSMTRTRDVMQLWSLLEACLQSNLMKRAFSILESLYLVPEHKQRFIEDYNMYLNSFSK
NDPNFPILKMNEKLTNDLETSFKDVNYNDKTLAIMIHHALNFHSTTSSMLLKPIISAY
LKMSVNGIREIFSCLDILTISDLNILMNDLKVITPSQLPNSVRPILESLTLSPTPVNN
IENEEGLNKVEAENDSKLHKASNASSDSIKKPSLDPLREVSFHGSTEVLSKDAEKLIA
VDTIGMRVIRHTLLGLSLTPEQKEQISKFKFDANDNVLKMKPTKNDDNNNSINFFEIY
NSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDFEEAKARGDISIEKNL
NVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKGLNKVDTNRLGYGPYLTLIDPGKM
CVITILELLKLNSTGGVIEGMRTARAVISVGKAIEMEFRSEQVLKSESQAFRDVNKKS
PEFKKLVQNAKSVFRSSQIEQSKILWPQSIRARIGSVLISMLIQVAKVSVQGVDPVTK
AKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLIASVQPQLLPMLVEPKPW
VNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASDNGDIDRVYDGLNVLGRTPWTVNRKV
FDVVSQVWNKGEGFLDIPGAQDEMVLPPAPPKNSDPSILRAWKLQVKTIANKFSSDRS
NRCDTNYKLEIARAFLGEKLYFPHNLDFRGRAYPLSPHFNHLGNDMSRGLLIFWHGKK
LGPSGLKWLKIHLSNLFGFDKLPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKP
WQALATCFELNEVMKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGATQVNLVPS
DKPQDVYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQTVMTNVYGVTYVGAT
FQIAKQLSPIFDDRKESLDFSKYLTKHVFSAIRELFHSAHLIQDWLGESAKRISKSIR
LDVDEKSFKNGNKPDFMSSVIWTTPLGLPIVQPYREESKKQVETNLQTVFISDPFAVN
PVNARRQKAGLPPNFIHSLDASHMLLSAAECGKQGLDFASVHDSYWTHASDIDTMNVV
LREQFIKLHEVDLVLRLKEEFDQRYKNYVKIGKLKRSTDLAQKIIRIRKDLSRKLGRS
TTLADEIYFEKKRQELLNSPLIEDRNVGEKMVTTVSLFEDITDLDALELENGGDENSG
MSVLLPLRLPEIPPKGDFDVTVLRNSQYFFS"
gene complement(<63016..>63993)
/gene="MOB2"
/locus_tag="YFL034C-B"
/gene_synonym="YFL035C; YFL035C-A"
/db_xref="GeneID:850508"
mRNA complement(join(<63016..63859,63974..>63993))
/gene="MOB2"
/locus_tag="YFL034C-B"
/gene_synonym="YFL035C; YFL035C-A"
/product="Mob2p"
/transcript_id="NM_001179931.1"
/db_xref="GeneID:850508"
CDS complement(join(63016..63859,63974..63993))
/gene="MOB2"
/locus_tag="YFL034C-B"
/gene_synonym="YFL035C; YFL035C-A"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11747810|PMID:12196508]"
/experiment="EXISTENCE:direct assay:GO:0005933 cellular
bud [PMID:12196508]"
/experiment="EXISTENCE:direct assay:GO:0005934 cellular
bud tip [PMID:11747810]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:11747810|PMID:12196508]"
/experiment="EXISTENCE:direct assay:GO:0030295 protein
kinase activator activity [PMID:12196508]"
/experiment="EXISTENCE:direct assay:GO:0043332 mating
projection tip [PMID:11747810]"
/experiment="EXISTENCE:genetic interaction:GO:0007118
budding cell apical bud growth [PMID:12972564]"
/experiment="EXISTENCE:mutant phenotype:GO:0000920 septum
digestion after cytokinesis [PMID:11747810|PMID:12196508]"
/experiment="EXISTENCE:mutant phenotype:GO:0001934
positive regulation of protein phosphorylation
[PMID:12196508]"
/experiment="EXISTENCE:mutant phenotype:GO:0007118 budding
cell apical bud growth [PMID:12972564]"
/experiment="EXISTENCE:mutant phenotype:GO:0007163
establishment or maintenance of cell polarity
[PMID:12196508]"
/note="Activator of Cbk1p kinase; component of the RAM
signaling network that regulates cellular polarity and
morphogenesis; activation of Cbk1p facilitates the
Ace2p-dependent daughter cell-specific transcription of
genes involved in cell separation; similar to Mob1p"
/codon_start=1
/product="Mob2p"
/protein_id="NP_116618.1"
/db_xref="GeneID:850508"
/db_xref="SGD:S000001859"
/translation="MSFFNFKAFGRNSKKNKNQPLNVAQPPAMNTIYSSPHSSNSRLS
LRNKHHSPKRHSQTSFPAQKSTPQSQQLTSTTPQSQQQEASERSESQQIMFLSEPFVR
TALVKGSFKTIVQLPKYVDLGEWIALNVFEFFTNLNQFYGVVAEYVTPDAYPTMNAGP
HTDYLWLDANNRQVSLPASQYIDLALTWINNKVNDKNLFPTKNGLPFPQQFSRDVQRI
MVQMFRIFAHIYHHHFDKIVHLSLEAHWNSFFSHFISFAKEFKIIDRKEMAPLLPLIE
SFEKQGKIIYN"
gene complement(<64243..>64932)
/gene="RPL22B"
/locus_tag="YFL034C-A"
/gene_synonym="YFL035C-B"
/db_xref="GeneID:850509"
mRNA complement(join(<64243..64599,64921..>64932))
/gene="RPL22B"
/locus_tag="YFL034C-A"
/gene_synonym="YFL035C-B"
/product="ribosomal 60S subunit protein L22B"
/transcript_id="NM_001184310.1"
/db_xref="GeneID:850509"
CDS complement(join(64243..64599,64921..64932))
/gene="RPL22B"
/locus_tag="YFL034C-A"
/gene_synonym="YFL035C-B"
/experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic
translation [PMID:6814480]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:6814480]"
/experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
large ribosomal subunit [PMID:6814480]"
/experiment="EXISTENCE:genetic interaction:GO:0002181
cytoplasmic translation [PMID:27478489]"
/note="Ribosomal 60S subunit protein L22A; required for
translation of long 5' UTR of IME1 mRNA and meiotic entry;
autoregulates splicing of its pre-m-RNA; homologous to
mammalian ribosomal protein L22, no bacterial homolog;
RPL22B has a paralog, RPL22A, that arose from the whole
genome duplication"
/codon_start=1
/product="ribosomal 60S subunit protein L22B"
/protein_id="NP_116619.1"
/db_xref="GeneID:850509"
/db_xref="SGD:S000006436"
/translation="MAPNTSRKQKVIKTLTVDVSSPTENGVFDPASYSKYLIDHIKVD
GAVGNLGNAIEVTEDGSIVTVVSSAKFSGKYLKYLTKKYLKKNQLRDWIRFVSIRQNQ
YKLVFYQVTPEDADEEEDDE"
gene <65477..>68698
/gene="MIL1"
/locus_tag="YFL034W"
/db_xref="GeneID:850510"
mRNA <65477..>68698
/gene="MIL1"
/locus_tag="YFL034W"
/product="Mil1p"
/transcript_id="NM_001179932.2"
/db_xref="GeneID:850510"
CDS 65477..68698
/gene="MIL1"
/locus_tag="YFL034W"
/experiment="EXISTENCE:direct assay:GO:0016020 membrane
[PMID:26658609]"
/experiment="EXISTENCE:direct assay:GO:0035650 AP-1
adaptor complex binding [PMID:26658609]"
/experiment="EXISTENCE:mutant phenotype:GO:0035652
clathrin-coated vesicle cargo loading [PMID:26658609]"
/note="Predicted lipase; binds variant medium clathrin
chain Apm2p and contributes to its membrane recruitment;
putative integral membrane protein that interacts with
Rpp0p component of ribosomal stalk"
/codon_start=1
/product="Mil1p"
/protein_id="NP_116583.2"
/db_xref="GeneID:850510"
/db_xref="SGD:S000001860"
/translation="MSDSEEDLGVQLKGLKIARHLKESGEHTDEESNSSPEHDCGLSN
QDDLTVMHTQAKEEVFKRREEDGTRTEDALHEGEAGKEGTGFPSSQSVCSPNEADSGI
DRADKPILLDPFKSVHDTDPVPGTKSRSNSDSDSDSDDGGWQEMPAVSSFNIYNHRGE
LELTSKVRNSEQASETSPTVPPGKNCKSVNDSRFDYTKMAAEQQAQRSYRTNKKTDFL
FDHKVLKKKINSSQTSVNLTSSPSTTSLNNEKNNDDDDDDSYDEYEDDVEPVNDLNRD
SQLNITKNLLSDMEKFAYVGAINILANQMCTNLATLCLCIDIKSHKKLAHRLQFTQKD
MAAWKTVVLSRLYDHLGISQEEIVMIEKLSLHKIQLEDLCKCLKTTQSIDNPWENDRD
HEEDGIEETTERMSPNEQNGSVQASTPDPEQSATPETPKAKQSPLSSDVPGKVLDPEN
VKSQDKLNIDVAWTIICDLFLICLQSSTYDSRSRTLLINFAKVLNMTSLEICEFERRV
TDSLDMEQSTEDQVWDEQDHMRNRRRSKRRKKMAYVALAMVGGSLVLGLSGGLLAPVI
GGGIAAGLSTIGITGATSFLTGVGGTTVVAVSSTAIGANIGARGMSKRMGSVRTFEFR
PLHNNRRVNLILTVSGWMVGNEDDVRLPFSTVDPVEGDLYSLYWEPEMLKSIGQTVSI
VATEIFTTSLQQILGATVLTALISSIQWPMALSKLGYILDNPWNVSLDRAWSAGKILA
DTLIARNLGARPITLVGFSIGARVIFSCLIELCKKKALGLIENVYLFGTPAVMKKEQL
VMARSVVSGRFVNGYSDKDWFLAYLFRAAAGGFSAVMGISTIENVEGIENINCTEFVD
GHLNYRKSMPKLLKRIGIAVLSEEFVEIEEMMNPEEVKRKRKLINDVDAAQKKLSERK
KHNSWVPKWLKPKKSKWKVMVEEAVEEGRDMQDLPENDVNNNENENPDEHEGIARQKR
RDAALVDHGALMHELQLIKQAMHEDEIKNKACLPGEDKEVESSNDFLGESHYKPPSTP
KINPPQSPNNFQLLSAGRTILPEDDDFDPRGKKKVEFSFPDDI"
rep_origin 68759..68861
/note="ARS603; Highly-efficient autonomously replicating
sequence on Chromosome VI; activated during the second
half of S phase in
67% of cell cycles"
/db_xref="SGD:S000007635"
gene complement(<69115..>74427)
/gene="RIM15"
/locus_tag="YFL033C"
/gene_synonym="TAK1"
/db_xref="GeneID:850511"
mRNA complement(<69115..>74427)
/gene="RIM15"
/locus_tag="YFL033C"
/gene_synonym="TAK1"
/product="protein kinase RIM15"
/transcript_id="NM_001179933.1"
/db_xref="GeneID:850511"
CDS complement(69115..74427)
/gene="RIM15"
/locus_tag="YFL033C"
/gene_synonym="TAK1"
/EC_number="2.7.11.1"
/experiment="EXISTENCE:direct assay:GO:0004672 protein
kinase activity
[PMID:9744870|PMID:9111339|PMID:24140345|PMID:16319894]"
/experiment="EXISTENCE:direct assay:GO:0004674 protein
serine/threonine kinase activity
[PMID:20471941|PMID:23273919]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14690612]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:14690612]"
/experiment="EXISTENCE:genetic interaction:GO:0010508
positive regulation of autophagy [PMID:25660547]"
/experiment="EXISTENCE:genetic interaction:GO:1903452
positive regulation of G1 to G0 transition
[PMID:23273919]"
/experiment="EXISTENCE:mutant phenotype:GO:0004674 protein
serine/threonine kinase activity [PMID:20471941]"
/experiment="EXISTENCE:mutant phenotype:GO:0010508
positive regulation of autophagy [PMID:25660547]"
/experiment="EXISTENCE:mutant phenotype:GO:0051039
positive regulation of transcription involved in meiotic
cell cycle [PMID:9111339]"
/experiment="EXISTENCE:mutant phenotype:GO:1901992
positive regulation of mitotic cell cycle phase transition
[PMID:23861665]"
/experiment="EXISTENCE:mutant phenotype:GO:1903452
positive regulation of G1 to G0 transition
[PMID:20471941|PMID:9744870]"
/note="Protein kinase involved in cell proliferation in
response to nutrients; glucose-repressible; involved in
signal transduction during cell proliferation in response
to nutrients, specifically the establishment of stationary
phase; identified as a regulator of IME2; phosphorylates
Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase"
/codon_start=1
/product="protein kinase RIM15"
/protein_id="NP_116620.1"
/db_xref="GeneID:850511"
/db_xref="SGD:S000001861"
/translation="MFNRSNTAGGSQAMKEGLGINKLSPISSNSNPSSLTSSNYEKYL
QLATEKNPCMILELELDGKVRYGSPQWNTITGVADDSGSSPTYIADLILGSDQDKGVF
QKATDMLLMNDDTSCTITFKIKAADYEGSAGCDDESTITTLEARGILIRDGHTQLPSH
TMWIVKPRTNDWSDFYANEDAQDDMVIQLSDNCDDIDIQLPEEFAKTLGFGAKIFVQY
LKRIRLEMIIDEFNLPLPKMELCRVCENFVPVWWLETHSQSCVCEHRTESLIQLLHDN
LLEQQAILANFTKDSEYKGSQIQVRSNNFLNQVLDSLRELCQDAIDINPSEMVPDLYH
SLSTFPQDNGNNNNNNNNNNNNNNALLDQFPIQKDTVSLNSYFQFSPRTNHNIQNVTS
WQSRFFLNDDQDPGLALLIHDTLDLARKKVDAVLRLDNAMTYSLKIKNEVNNYVVQLI
REQIEINKHAILTHPMNLRSSSIFHSPLPQIHSQQPEAENLIYSSSTPLQVQHDQCAS
FEAPSKSHLEPIPFPVSSIEETPTANDIRHPSPLPRSCSNTVMKLPTPRRKLDSNGLF
SDAYLNADIIPNPSIESTISIDRDNNTNSRGSSMKQYGIGEATDSRTSNSERPSSSSS
RLGIRSRSITPRQKIEYSHVDNDDRTNEMLSRDKDSLQPQPSVDTTITSSTQATTTGT
KTNSNNSTNSVLPKLMTSISLTPRRGSPSFGNLASHSMQQTNSFKLIHDKSPISSPFT
FSKDFLTPEQHPSNIARTDSINNAMLTSPNMPLSPLLLATNQTVKSPTPSIKDYDILK
PISKGAYGSVYLARKKLTGDYFAIKVLRKSDMIAKNQVTNVKSERAIMMVQSDKPYVA
RLFASFQNKDNLFLVMEYLPGGDLATLIKMMGYLPDQWAKQYLTEIVVGVNDMHQNGI
IHHDLKPENLLIDNAGHVKLTDFGLSRAGLIRRHKFVPHKSSLSISSTLPIDNPANNF
TMNNNNSNHSQLSTPDSFTSDHKQYNRSKKSSLGQQYEHSEYSSTSNSHSMTPTPSTN
TVVYPSYYRGKDRSHGSSNIDLPASLRRSESQLSFSLLDISRSSTPPLANPTNSNANN
IMRRKSLTENKSFSNDLLSSDAIAATNTNINSNNNISLSPAPSDLALFYPDDSKQNKK
FFGTPDYLAPETIEGKGEDNKQCDWWSVGCIFFELLLGYPPFHAETPDAVFKKILSGV
IQWPEFKNEEEEREFLTPEAKDLIEKLLVVDPAKRLGAKGIQEIKDHPYFKNVDWDHV
YDEEASFVPTIDNPEDTDYFDLRGAELQDFGDDIENDNANILFGKHGINTDVSELSAA
NLSPPLNHKNILSRKLSMSNTTNRSSNNSNSSVHDFGAHTPVNKLSIASVLESVPQET
GYITPNGTGTTTTSAKNSPNLKNLSLAIPPHMRDRRSSKLNDSQTEFGSFNFRNLSAL
DKANKDAINRLKSEHFSEQPGVHRRTSSASLMGSSSDGSVSTPGSNASNTTSGGKLKI
HKPTISGSPSTFGTFPKTFLRSDSFSTRSYSPERSISIDSSTLSRKGSIIGDNQQTTA
NSSDSPTMTKFKSPLSPANTTTVSSYFSRQRVLSKSFSQRTNSSDLSAEESDRLQAIS
RVNSLRNRRRSGRKSSSTSEIGYHMDVLVCEPIPIHRYRVTKDLENLGCTVVSVGAGD
ELVSRATSGVSFDLIMTALKLPKLGAIDIVQLLKQTNGANSTTPIVAITNYFQEAATS
RVFDDVLEKPVKLDELKKLVAKYALKKSQEDEEHTILSDSDETH"
gene <75179..>76147
/gene="HAC1"
/locus_tag="YFL031W"
/gene_synonym="ERN4; IRE15"
/db_xref="GeneID:850513"
mRNA join(<75179..75839,76092..>76147)
/gene="HAC1"
/locus_tag="YFL031W"
/gene_synonym="ERN4; IRE15"
/product="transcription factor HAC1"
/transcript_id="NM_001179935.1"
/db_xref="GeneID:850513"
CDS join(75179..75839,76092..76147)
/gene="HAC1"
/locus_tag="YFL031W"
/gene_synonym="ERN4; IRE15"
/experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding
transcription factor activity, RNA polymerase II-specific
[PMID:15141165|PMID:9077435]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:8898193]"
/experiment="EXISTENCE:direct assay:GO:0010674 negative
regulation of transcription from RNA polymerase II
promoter involved in meiotic cell cycle [PMID:15141165]"
/experiment="EXISTENCE:direct assay:GO:0045944 positive
regulation of transcription by RNA polymerase II
[PMID:9077435]"
/experiment="EXISTENCE:mutant phenotype:GO:0000981
DNA-binding transcription factor activity, RNA polymerase
II-specific [PMID:15141165|PMID:9077435]"
/experiment="EXISTENCE:mutant phenotype:GO:0010674
negative regulation of transcription from RNA polymerase
II promoter involved in meiotic cell cycle
[PMID:15141165]"
/experiment="EXISTENCE:mutant phenotype:GO:0030968
endoplasmic reticulum unfolded protein response
[PMID:16582425]"
/experiment="EXISTENCE:mutant phenotype:GO:0034976
response to endoplasmic reticulum stress [PMID:26966233]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:9077435|PMID:8898193]"
/note="Basic leucine zipper (bZIP) transcription factor
(ATF/CREB1 homolog); regulates unfolded protein response
via UPRE binding and membrane biogenesis; translation
initiation repressed under non-stress conditions by
un-spliced intron that interacts with 5'-UTR; under ER
stress Ire1p nuclease cleaves out inhibitory intron and
triggers efficient Hac1p translation; two functional forms
of Hac1p are produced; protein abundance increases in
response to DNA replication stress"
/codon_start=1
/product="transcription factor HAC1"
/protein_id="NP_116622.1"
/db_xref="GeneID:850513"
/db_xref="SGD:S000001863"
/translation="MEMTDFELTSNSQSNLAIPTNFKSTLPPRKRAKTKEEKEQRRIE
RILRNRRAAHQSREKKRLHLQYLERKCSLLENLLNSVNLEKLADHEDALTCSHDAFVA
SLDEYRDFQSTRGASLDTRASSHSSSDTFTPSPLNCTMEPATLSPKSMRDSASDQETS
WELQMFKTENVPESTTLPAVDNNNLFDAVASPLADPLCDDIAGNSLPFDNSIDLDNWR
NPEAQSGLNSFELNDFFITS"
gene <76831..>77988
/gene="AGX1"
/locus_tag="YFL030W"
/db_xref="GeneID:850514"
mRNA <76831..>77988
/gene="AGX1"
/locus_tag="YFL030W"
/product="alanine--glyoxylate transaminase"
/transcript_id="NM_001179936.1"
/db_xref="GeneID:850514"
CDS 76831..77988
/gene="AGX1"
/locus_tag="YFL030W"
/EC_number="2.6.1.44"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0008453
alanine-glyoxylate transaminase activity [PMID:16226833]"
/experiment="EXISTENCE:direct assay:GO:0019265 glycine
biosynthetic process, by transamination of glyoxylate
[PMID:16226833]"
/experiment="EXISTENCE:mutant phenotype:GO:0008453
alanine-glyoxylate transaminase activity [PMID:14745783]"
/note="Alanine:glyoxylate aminotransferase (AGT);
catalyzes the synthesis of glycine from glyoxylate, which
is one of three pathways for glycine biosynthesis in
yeast; similar to mammalian and plant alanine:glyoxylate
aminotransferases; human homolog AGXT complements yeast
null mutant"
/codon_start=1
/product="alanine--glyoxylate transaminase"
/protein_id="NP_116623.1"
/db_xref="GeneID:850514"
/db_xref="SGD:S000001864"
/translation="MTKSVDTLLIPGPIILSGAVQKALDVPSLGHTSPEFVSIFQRVL
KNTRAVFKSAAASKSQPFVLAGSGTLGWDIFASNFILSKAPNKNVLVVSTGTFSDRFA
DCLRSYGAQVDVVRPLKIGESVPLELITEKLSQNSYGAVTVTHVDTSTAVLSDLKAIS
QAIKQTSPETFFVVDAVCSIGCEEFEFDEWGVDFALTASQKAIGAPAGLSISLCSSRF
MDYALNDSKNGHVHGYFSSLRRWTPIMENYEAGKGAYFATPPVQLINSLDVALKEILE
EGLHKRWDLHREMSDWFKDSLVNGLQLTSVSRYPSNMSAHGLTAVYVADPPDVIAFLK
SHGVVIAGGIHKDIGPKYIRIGHMGVTACNKNLPYMKNCFDLIKLALQRKK"
gene complement(<78055..>79161)
/gene="CAK1"
/locus_tag="YFL029C"
/gene_synonym="CIV1"
/db_xref="GeneID:850515"
mRNA complement(<78055..>79161)
/gene="CAK1"
/locus_tag="YFL029C"
/gene_synonym="CIV1"
/product="cyclin-dependent protein kinase-activating
kinase CAK1"
/transcript_id="NM_001179937.1"
/db_xref="GeneID:850515"
CDS complement(78055..79161)
/gene="CAK1"
/locus_tag="YFL029C"
/gene_synonym="CIV1"
/EC_number="2.7.11.22"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:9819350]"
/experiment="EXISTENCE:direct assay:GO:0019912
cyclin-dependent protein kinase activating kinase activity
[PMID:10373527|PMID:8752210|PMID:8752211|PMID:8781234]"
/experiment="EXISTENCE:genetic interaction:GO:0060633
negative regulation of transcription initiation by RNA
polymerase II [PMID:19269370]"
/experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M
transition of mitotic cell cycle
[PMID:8752210|PMID:8752211]"
/experiment="EXISTENCE:mutant phenotype:GO:0019912
cyclin-dependent protein kinase activating kinase activity
[PMID:10373527|PMID:8752210|PMID:8752211|PMID:8781234]"
/experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic
cell cycle [PMID:11739722]"
/note="Cyclin-dependent kinase-activating kinase; required
for passage through the cell cycle; phosphorylates and
activates Cdc28p; nucleotide-binding pocket differs
significantly from those of most other protein kinases;
required for premeiotic DNA synthesis, expression of early
and middle sporulation specific genes and direct
phosphorylation of the Smk1p MAPK to regulate spore
morphogenesis"
/codon_start=1
/product="cyclin-dependent protein kinase-activating
kinase CAK1"
/protein_id="NP_116624.1"
/db_xref="GeneID:850515"
/db_xref="SGD:S000001865"
/translation="MKLDSIDITHCQLVKSTRTARIYRSDTYAIKCLALDFDIPPHNA
KFEVSILNKLGNKCKHILPLLESKATDNNDLLLLFPFEEMNLYEFMQMHYKRDRRKKN
PYYDLLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIAFLHENKIIHRDIKPQ
NIMLTNNTSTVSPKLYIIDFGISYDMANNSQTSAEPMDSKVTDISTGIYKAPEVLFGV
KCYDGGVDVWSLLIIISQWFQRETSRMGHVPAMIDDGSDDMNSDGSDFRLICSIFEKL
GIPSIQKWEEVAQHGSVDAFVGMFGADGDGKYVLDQEKDVQISIVERNMPRLDEIADV
KVKQKFINCILGMVSFSPNERWSCQRILQELEKP"
gene complement(<79344..>80213)
/gene="CAF16"
/locus_tag="YFL028C"
/db_xref="GeneID:850516"
mRNA complement(<79344..>80213)
/gene="CAF16"
/locus_tag="YFL028C"
/product="putative ATP-binding cassette family ATPase
CAF16"
/transcript_id="NM_001179938.1"
/db_xref="GeneID:850516"
CDS complement(79344..80213)
/gene="CAF16"
/locus_tag="YFL028C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0030014 CCR4-NOT
complex [PMID:11113136]"
/experiment="EXISTENCE:mutant phenotype:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:11113136]"
/note="Part of evolutionarily-conserved CCR4-NOT
regulatory complex; contains single ABC-type ATPase domain
but no transmembrane domain; interacts with several
subunits of Mediator"
/codon_start=1
/product="putative ATP-binding cassette family ATPase
CAF16"
/protein_id="NP_116625.1"
/db_xref="GeneID:850516"
/db_xref="SGD:S000001866"
/translation="MVSQFAIEVRNLTYKFKESSDPSVVDINLQIPWNTRSLVVGANG
AGKSTLLKLLSGKHLCLDGKILVNGLDPFSPLSMNQVDDDESVEDSTNYQTTTYLGTE
WCHMSIINRDIGVLELLKSIGFDHFRERGERLVRILDIDVRWRMHRLSDGQKRRVQLA
MGLLKPWRVLLLDEVTVDLDVIARARLLEFLKWETETRRCSVVYATHIFDGLAKWPNQ
VYHMKSGKIVDNLDYQKDVEFSEVVNAKVNGQVAFENDNNKVVISKVNSLHPLALEWL
KRDNQIPDKEIGI"
gene complement(<80419..>81912)
/gene="GYP8"
/locus_tag="YFL027C"
/db_xref="GeneID:850517"
mRNA complement(<80419..>81912)
/gene="GYP8"
/locus_tag="YFL027C"
/product="GTPase-activating protein GYP8"
/transcript_id="NM_001179939.1"
/db_xref="GeneID:850517"
CDS complement(80419..81912)
/gene="GYP8"
/locus_tag="YFL027C"
/experiment="EXISTENCE:direct assay:GO:0005096 GTPase
activator activity [PMID:12189143]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:12189143]"
/experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
[PMID:36164978]"
/experiment="EXISTENCE:mutant phenotype:GO:0016192
vesicle-mediated transport [PMID:12189143]"
/note="GTPase-activating protein for yeast Rab family
members; Ypt1p is the preferred in vitro substrate but
also acts on Sec4p, Ypt31p and Ypt32p; involved in the
regulation of ER to Golgi vesicle transport; localizes to
the ER and peroxisomes"
/codon_start=1
/product="GTPase-activating protein GYP8"
/protein_id="NP_444296.1"
/db_xref="GeneID:850517"
/db_xref="SGD:S000001867"
/translation="MPLRSLFHTNQSSHDKDALTRGGYNAYLESLSRCDSGKAEEQKG
KVISKLLEKKDVRALRYIGLGPLGFVNNSLRKDCWYELLASQLLIDDATEYITPVEKH
KDEGQVILDAERSFGGIVDKNLKLQLRKLLVELITRVLRKYPTLNYYQGYHDIVSVFI
MCFSWNVTKENGLELENLSLQEEIDMERLFYCIEAFTLLYLRDFMMNSLDFSFEQLRV
ISSLIKESNMKFYNLFKFDENEPLFAIGSILTIFAHNLKPIDSGDNNLHKILFQIFDM
TISMQSMRLPLIIYKNLLLQNASEISKQIEANSDFFENDFDLRHGAIQTVLQKKLYDE
ALWEEVLQITRKDATTASKKALKRVSLNKYSALLNTACGKPGCFDMSTIIFYLSEQTK
MNEHYKEEKYHGVAARSKTRALVQRLGHFLPSKYNRWSKISLLIGIVAILYQLRTTRS
LSLVLNLRYMISTKLKDLSHININLHHVSHIWVDPIRDILKLGHPTR"
gene <82580..>83875
/gene="STE2"
/locus_tag="YFL026W"
/db_xref="GeneID:850518"
mRNA <82580..>83875
/gene="STE2"
/locus_tag="YFL026W"
/product="alpha-factor pheromone receptor STE2"
/transcript_id="NM_001179940.2"
/db_xref="GeneID:850518"
CDS 82580..83875
/gene="STE2"
/locus_tag="YFL026W"
/experiment="EXISTENCE:direct assay:GO:0000755 cytogamy
[PMID:17369365]"
/experiment="EXISTENCE:direct assay:GO:0004934 mating-type
alpha-factor pheromone receptor activity [PMID:2161538]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:2839507]"
/experiment="EXISTENCE:genetic interaction:GO:0004934
mating-type alpha-factor pheromone receptor activity
[PMID:9742115]"
/experiment="EXISTENCE:mutant phenotype:GO:0000750
pheromone-dependent signal transduction involved in
conjugation with cellular fusion [PMID:3037311]"
/experiment="EXISTENCE:mutant phenotype:GO:0000755
cytogamy [PMID:17369365]"
/experiment="EXISTENCE:mutant phenotype:GO:0004934
mating-type alpha-factor pheromone receptor activity
[PMID:6360378|PMID:9742115]"
/note="Receptor for alpha-factor pheromone; seven
transmembrane-domain GPCR that interacts with both
pheromone and a heterotrimeric G protein to initiate the
signaling response that leads to mating between haploid a
and alpha cells"
/codon_start=1
/product="alpha-factor pheromone receptor STE2"
/protein_id="NP_116627.2"
/db_xref="GeneID:850518"
/db_xref="SGD:S000001868"
/translation="MSDAAPSLSNLFYDPTYNPGQSTINYTSIYGNGSTITFDELQGL
VNSTVTQAIMFGVRCGAAALTLIVMWMTSRSRKTPIFIINQVSLFLIILHSALYFKYL
LSNYSSVTYALTGFPQFISRGDVHVYGATNIIQVLLVASIETSLVFQIKVIFTGDNFK
RIGLMLTSISFTLGIATVTMYFVSAVKGMIVTYNDVSATQDKYFNASTILLASSINFM
SFVLVVKLILAIRSRRFLGLKQFDSFHILLIMSCQSLLVPSIIFILAYSLKPNQGTDV
LTTVATLLAVLSLPLSSMWATAANNASKTNTITSDFTTSTDRFYPGTLSSFQTDSINN
DAKSSLRSRLYDLYPRRKETTSDKHSERTFVSETADDIEKNQFYQLPTPTSSKNTRIG
PFADASYKEGEVEPVDMYTPDTAADEEARKFWTEDNNNL"
gene complement(<84145..>87234)
/gene="BST1"
/locus_tag="YFL025C"
/gene_synonym="PER17"
/db_xref="GeneID:850519"
mRNA complement(<84145..>87234)
/gene="BST1"
/locus_tag="YFL025C"
/gene_synonym="PER17"
/product="Bst1p"
/transcript_id="NM_001179941.1"
/db_xref="GeneID:850519"
CDS complement(84145..87234)
/gene="BST1"
/locus_tag="YFL025C"
/gene_synonym="PER17"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762|PMID:8862519]"
/experiment="EXISTENCE:genetic interaction:GO:0006505 GPI
anchor metabolic process [PMID:14734546]"
/experiment="EXISTENCE:genetic interaction:GO:0050185
phosphatidylinositol deacylase activity [PMID:14734546]"
/experiment="EXISTENCE:mutant phenotype:GO:0006621 protein
retention in ER lumen [PMID:8862519]"
/experiment="EXISTENCE:mutant phenotype:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:8862519]"
/experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle
organization [PMID:8862519]"
/experiment="EXISTENCE:mutant phenotype:GO:0030433
ubiquitin-dependent ERAD pathway [PMID:11673477]"
/experiment="EXISTENCE:mutant phenotype:GO:0034368
protein-lipid complex remodeling [PMID:27325793]"
/note="GPI inositol deacylase of the endoplasmic reticulum
(ER); negatively regulates COPII vesicle formation;
prevents production of vesicles with defective subunits;
required for proper discrimination between resident ER
proteins and Golgi-bound cargo molecules; functional
ortholog of human PGAP1, mutation of which is associated
with intellectual disability and encephalopathy"
/codon_start=1
/product="Bst1p"
/protein_id="NP_116628.1"
/db_xref="GeneID:850519"
/db_xref="SGD:S000001869"
/translation="MGIRRLVSVITRPIINKVNSSGQYSRVLATREDQDKASPKYMNN
DKIAKKPYTYRLFSILGILSICSLLLISLLKPFNGADAPQCESIYMFPSYARIDGFDE
RYTPLAHKYHLYLYREQSVDREPLNGDELQLDGIPVLFIPGNAGSFRQCRSIASACSN
IYFDSNTRATLRNENVRNLDFFTADFNEDFTAFHGETMLDQAEYLNDAIKYILSLYER
TPDYPHPKPQSVIIVGHSMGGIVSRVMLTLKNHVPGSISTILTLSSPHAASPVTFDGD
ILKLYKNTNEYWRKQLSQNDSFFSKNISLVSITGGILDTTLPADYASVEDLVSLENGF
TSFTTTIPDVWTPIDHLAIVWCKQLREVLARLLLESIDASKPEKVKPLNQRLQIARKL
LLSGFEDYSWMNSKLNYPQENLQEFSDNFFSDYATLEMNDVLDFEMFNLEKWHNNYTK
INIPSNISSTEHLHFTLLTSLDMPMIYFCTESRVNLSCITAVDSILTVPRSSKDTQFA
ADSSFGEAKNPFKAVSVGKNILQKYDYLMISKPTYGEFSEQEGMEDNQGFLLALLRNV
SNVQIVNTTPSQILLFGEQLHLDGKDIEQVISFSNLWDSLLSYKLETKIEASNEGIAS
EETLFQPFIRQWVYEPFESKWHLNIINKSLDINMHNVAPFIPLNESEPRSLQLSFFIP
PGMSLEAKMTINWSLTLKMLFIRYRLALASFPVAFIALVLSYQFYWYNKTSEFPSFDS
TLGYILRKHGILMFFTLFLASPVVNNKLVQRILYLLDPVGLNYPFLLSERNMHANFYY
LGIRDWFMSTIGILFGVMTVGLLALVSKIFGSLEILVIFLQRKLSKKNTEDKEAFDTI
EHKAYGKGRLMASVLLLLLVFFHIPYQMAFVISLVIQIATCIRVALLKLSNNEQKLNL
LNYNMTLLLLLLFVSAINIPIIIVFLHNVAIKWETSFRSHHNILAVAPIIFLVGNNSI
FKMPNSVPLDTWDGKVTIILFVYLTVFSFIYGIRNLYWIHHLVNIICAWLLFFETIH"
gene complement(<87847..>90345)
/gene="EPL1"
/locus_tag="YFL024C"
/db_xref="GeneID:850520"
mRNA complement(<87847..>90345)
/gene="EPL1"
/locus_tag="YFL024C"
/product="Epl1p"
/transcript_id="NM_001179942.1"
/db_xref="GeneID:850520"
CDS complement(87847..90345)
/gene="EPL1"
/locus_tag="YFL024C"
/experiment="EXISTENCE:direct assay:GO:0004402 histone
acetyltransferase activity [PMID:10911987|PMID:17274630]"
/experiment="EXISTENCE:direct assay:GO:0006281 DNA repair
[PMID:15610740|PMID:16135807]"
/experiment="EXISTENCE:direct assay:GO:0006357 regulation
of transcription by RNA polymerase II [PMID:10911987]"
/experiment="EXISTENCE:direct assay:GO:0032777 Piccolo
NuA4 histone acetyltransferase complex [PMID:12782659]"
/experiment="EXISTENCE:direct assay:GO:0035267 NuA4
histone acetyltransferase complex
[PMID:10911987|PMID:15485911]"
/experiment="EXISTENCE:mutant phenotype:GO:0016239
positive regulation of macroautophagy [PMID:22539722]"
/note="Subunit of NuA4, an essential histone H4/H2A
acetyltransferase complex; conserved region at N-terminus
is essential for interaction with the NPC (nucleosome core
particle); required for autophagy; homologous to
Drosophila Enhancer of Polycomb; coding sequence contains
length polymorphisms in different strains"
/codon_start=1
/product="Epl1p"
/protein_id="NP_116629.1"
/db_xref="GeneID:850520"
/db_xref="SGD:S000001870"
/translation="MPTPSNAIEINDGSHKSGRSTRRSGSRSAHDDGLDSFSKGDSGA
GASAGSSNSRFRHRKISVKQHLKIYLPNDLKHLDKDELQQREVVEIETGVEKNEEKEV
HLHRILQMGSGHTKHKDYIPTPDASMTWNEYDKFYTGSFQETTSYIKFSATVEDCCGT
NYNMDERDETFLNEQVNKGSSDILTEDEFEILCSSFEHAIHERQPFLSMDPESILSFE
ELKPTLIKSDMADFNLRNQLNHEINSHKTHFITQFDPVSQMNTRPLIQLIEKFGSKIY
DYWRERKIEVNGYEIFPQLKFERPGEKEEIDPYVCFRRREVRHPRKTRRIDILNSQRL
RALHQELKNAKDLALLVAKRENVSLNWINDELKIFDQRVKIKNLKRSLNISGEDDDLI
NHKRKRPTIVTVEQREAELRKAELKRAAAAAAAAKAKNNKRNNQLEDKSSRLTKQQQQ
QLLQQQQQQQQNALKTENGKQLANASSSSTSQPITSHVYVKLPSSKIPDIVLEDVDAL
LNSKEKNARKFVQEKMEKRKIEDADVFFNLTDDPFNPVFDMSLPKNFSTSNVPFASIA
SSKFQIDRSFYSSHLPEYLKGISDDIRIYDSNGRSRNKDNYNLDTKRIKKTELYDPFQ
ENLEIHSREYPIKFRKRVGRSNIKYVDRMPNFTTSSTKSACSLMDFVDFDSIEKEQYS
REGSNDTDSINVYDSKYDEFVRLYDKWKYDSPQNEYGIKFSDEPARLNQISNDTQVIR
FGTMLGTKSYEQLREATIKYRRDYITRLKQKHIQHLQQQQQQQQQQQQQAQQQKQKSQ
NNNSNSSNSLKKLNDSLINSEAKQNSSITQKNSS"
gene <90986..>93376
/gene="BUD27"
/locus_tag="YFL023W"
/gene_synonym="URI1"
/db_xref="GeneID:850521"
mRNA <90986..>93376
/gene="BUD27"
/locus_tag="YFL023W"
/gene_synonym="URI1"
/product="Bud27p"
/transcript_id="NM_001179943.1"
/db_xref="GeneID:850521"
CDS 90986..93376
/gene="BUD27"
/locus_tag="YFL023W"
/gene_synonym="URI1"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:18959479]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:19387492]"
/experiment="EXISTENCE:genetic interaction:GO:0001731
formation of translation preinitiation complex
[PMID:19387492]"
/experiment="EXISTENCE:mutant phenotype:GO:0001731
formation of translation preinitiation complex
[PMID:19387492]"
/experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA
processing [PMID:32503921]"
/experiment="EXISTENCE:mutant phenotype:GO:0042791 5S
class rRNA transcription by RNA polymerase III
[PMID:32503921]"
/experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA
transcription by RNA polymerase III [PMID:32503921]"
/experiment="EXISTENCE:mutant phenotype:GO:1990113 RNA
polymerase I assembly [PMID:23459708]"
/experiment="EXISTENCE:mutant phenotype:GO:1990114 RNA
polymerase II core complex assembly [PMID:23459708]"
/experiment="EXISTENCE:mutant phenotype:GO:1990115 RNA
polymerase III assembly [PMID:23459708]"
/experiment="EXISTENCE:mutant phenotype:GO:2001209
positive regulation of transcription elongation by RNA
polymerase I [PMID:32503921]"
/note="Unconventional prefoldin protein involved in
translation initiation; required for correct assembly of
RNAP I, II, and III in an Rpb5p-dependent manner; shuttles
between nucleus and cytoplasm; mutants have inappropriate
expression of nutrient sensitive genes due to
translational derepression of Gcn4p transcription factor;
diploid mutants show random budding; mutations affect TOR
signaling; ortholog of human URI/RMP"
/codon_start=1
/product="Bud27p"
/protein_id="NP_683715.1"
/db_xref="GeneID:850521"
/db_xref="SGD:S000001871"
/translation="MDLLAASVESTLKNLQDKRNFLSEQREHYIDIRSRLVRFINDND
DGEEEGEGQGMVFGDIIISTSKIYLSLGYEYYVEKTKEEAITFVDDKLKLMEDAIEQF
NLKIEEAKKTLDNLNHMEDGNGIEEDEANNDEDFLPSMEIREELDDEGNVISSSVTPT
TKQPSQSNSKKEQTPAVGPKEKGLAKEKKSKSFEENLKGKLLKRNDEVKKKVQPSKVD
TENVYTFADLVQQMDQQDELEDGYIETDEINYDYDAFENSNFKVNDNYEEDDEDEDEE
EYLNHSIIPGFEAQSSFLQQIQRLRAQKQSQDHEREEGDVNKSLKPILKKSSFAENSD
KKQKKKQVGFASSLEIHEVENLKEENKRQMQSFAVPMYETQESTGIANKMTSDEFDGD
LFAKMLGVQEADEVHEKYKEELINQERLEGEASRSNRRTRVSRFRKDRASKKENTLST
FKQETTRSVENEVVEKEPVVGDIIEKEPVVGDVIEKEPVVGDVIEKEPAVTDIVEREP
AVNDIVERKPVVGDIIEKEPTINDIVEKEPEINSKSEFETPFKKKKLKSLQKPRSSKS
MKKKFDPKILENISDDDYDDDDDGNKKLLSNKSKNNTDEQDKFPSKIQEVSRSMAKTG
ATVGSEPVRITNVDYHALGGNLDDMVKAYSLGLYDDDLEEDPGTIVEKLEDFKEYNKQ
VELLRDEIRDFQLENKPVTMEEEENDGNVMNDIIEHEFPESYTNDEDEVALHPGRLQE
EVAIEYRRLKEATASKWQSSSPAAHTEGELEPIDKFGNPVKTSRFRSQRLHMDSKP"
gene complement(<93499..>95010)
/gene="FRS2"
/locus_tag="YFL022C"
/db_xref="GeneID:850522"
mRNA complement(<93499..>95010)
/gene="FRS2"
/locus_tag="YFL022C"
/product="phenylalanine--tRNA ligase subunit alpha"
/transcript_id="NM_001179944.2"
/db_xref="GeneID:850522"
CDS complement(93499..95010)
/gene="FRS2"
/locus_tag="YFL022C"
/EC_number="6.1.1.20"
/experiment="EXISTENCE:direct assay:GO:0004826
phenylalanine-tRNA ligase activity
[PMID:16162501|PMID:166841]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0006432
phenylalanyl-tRNA aminoacylation
[PMID:16162501|PMID:166841]"
/experiment="EXISTENCE:direct assay:GO:0009328
phenylalanine-tRNA ligase complex [PMID:3049607]"
/experiment="EXISTENCE:mutant phenotype:GO:0002161
aminoacyl-tRNA editing activity [PMID:27226603]"
/note="Alpha subunit of cytoplasmic phenylalanyl-tRNA
synthetase; forms a tetramer with Frs1p to form active
enzyme; evolutionarily distant from mitochondrial
phenylalanyl-tRNA synthetase based on protein sequence,
but substrate binding is similar"
/codon_start=1
/product="phenylalanine--tRNA ligase subunit alpha"
/protein_id="NP_116631.1"
/db_xref="GeneID:850522"
/db_xref="SGD:S000001872"
/translation="MSDFQLEILKKLDELDEIKSTLATFPQHGSQDVLSALNSLKAHN
KLEFSKVDTVTYDLTKEGAQILNEGSYEIKLVKLIQELGQLQIKDVMSKLGPQVGKVG
QARAFKNGWIAKNASNELELSAKLQNTDLNELTDETQSILAQIKNNSHLDSIDAKILN
DLKKRKLIAQGKITDFNVTKGPEFSTDLTKLETDLTSDMVSTNAYKDLKFKPYNFNSQ
GVQISSGALHPLNKVREEFRQIFFSMGFTEMPSNQYVETGFWNFDALYVPQQHPARDL
QDTFYIKDPLTADLPDDKTYMDNIKAVHEQGRFGSIGYRYNWKPEECQKLVLRTHSTA
ISARMLHDLAKDPKPTRLFSIDRVFRNEAVDATHLAEFHQVEGVLADYNITLGDLIKF
MEEFFERMGVTGLRFKPTYNPYTEPSMEIFSWHEGLQKWVEIGNSGMFRPEMLESMGL
PKDLRVLGWGLSLERPTMIKYKVQNIRELLGHKVSLDFIETNPAARLDEDLYE"
gene <95966..>97498
/gene="GAT1"
/locus_tag="YFL021W"
/gene_synonym="MEP80; NIL1"
/db_xref="GeneID:850523"
mRNA <95966..>97498
/gene="GAT1"
/locus_tag="YFL021W"
/gene_synonym="MEP80; NIL1"
/product="Gat1p"
/transcript_id="NM_001179945.1"
/db_xref="GeneID:850523"
CDS 95966..97498
/gene="GAT1"
/locus_tag="YFL021W"
/gene_synonym="MEP80; NIL1"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:10799523]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:10799523]"
/experiment="EXISTENCE:genetic interaction:GO:0001080
nitrogen catabolite activation of transcription from RNA
polymerase II promoter [PMID:7568152]"
/experiment="EXISTENCE:genetic interaction:GO:0043565
sequence-specific DNA binding [PMID:7568152]"
/experiment="EXISTENCE:genetic interaction:GO:0090294
nitrogen catabolite activation of transcription
[PMID:7568152|PMID:8622686]"
/experiment="EXISTENCE:mutant phenotype:GO:0001080
nitrogen catabolite activation of transcription from RNA
polymerase II promoter [PMID:7568152]"
/experiment="EXISTENCE:mutant phenotype:GO:0001228
DNA-binding transcription activator activity, RNA
polymerase II-specific [PMID:9106207]"
/experiment="EXISTENCE:mutant phenotype:GO:0090294
nitrogen catabolite activation of transcription
[PMID:7568152|PMID:8622686]"
/experiment="EXISTENCE:physical interaction:GO:0005634
nucleus [PMID:19380492]"
/note="Transcriptional activator of nitrogen catabolite
repression genes; contains a GATA-1-type zinc finger
DNA-binding motif; activity and localization regulated by
nitrogen limitation and Ure2p; different translational
starts produce two major and two minor isoforms that are
differentially regulated and localized"
/codon_start=1
/product="Gat1p"
/protein_id="NP_116632.1"
/db_xref="GeneID:850523"
/db_xref="SGD:S000001873"
/translation="MHVFFPLLFRPSPVLFIACAYIYIDIYIHCTRCTVVNITMSTNR
VPNLDPDLNLNKEIWDLYSSAQKILPDSNRILNLSWRLHNRTSFHRINRIMQHSNSIM
DFSASPFASGVNAAGPGNNDLDDTDTDNQQFFLSDMNLNGSSVFENVFDDDDDDDDVE
THSIVHSDLLNDMDSASQRASHNASGFPNFLDTSCSSSFDDHFIFTNNLPFLNNNSIN
NNHSHNSSHNNNSPSIANNTNANTNTNTSASTNTNSPLLRRNPSPSIVKPGSRRNSSV
RKKKPALKKIKSSTSVQSSATPPSNTSSNPDIKCSNCTTSTTPLWRKDPKGLPLCNAC
GLFLKLHGVTRPLSLKTDIIKKRQRSSTKINNNITPPPSSSLNPGAAGKKKNYTASVA
ASKRKNSLNIVAPLKSQDIPIPKIASPSIPQYLRSNTRHHLSSSVPIEAETFSSFRPD
MNMTMNMNLHNASTSSFNNEAFWKPLDSAIDHHSGDTNPNSNMNTTPNGNLSLDWLNL
NL"
gene complement(<99231..>99599)
/gene="PAU5"
/locus_tag="YFL020C"
/db_xref="GeneID:850524"
mRNA complement(<99231..>99599)
/gene="PAU5"
/locus_tag="YFL020C"
/product="seripauperin PAU5"
/transcript_id="NM_001179946.1"
/db_xref="GeneID:850524"
CDS complement(99231..99599)
/gene="PAU5"
/locus_tag="YFL020C"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:18312373]"
/experiment="EXISTENCE:direct assay:GO:0016020 membrane
[PMID:18312373]"
/note="Member of the seripauperin multigene family;
encoded mainly in subtelomeric regions; induced during
alcoholic fermentation; induced by low temperature and
also by anaerobic conditions; negatively regulated by
oxygen and repressed by heme"
/codon_start=1
/product="seripauperin PAU5"
/protein_id="NP_116633.1"
/db_xref="GeneID:850524"
/db_xref="SGD:S000001874"
/translation="MVKLTSIAAGVAAIAAGASAAATTTLSQSDERVNLVELGVYVSD
IRAHLAEYYSFQAAHPTETYPVEIAEAVFNYGDFTTMLTGIPADQVTRVITGVPWYSS
RLKPAISSALSADGIYTIAN"
gene complement(<100252..>100605)
/locus_tag="YFL019C"
/db_xref="GeneID:850525"
mRNA complement(<100252..>100605)
/locus_tag="YFL019C"
/product="uncharacterized protein"
/transcript_id="NM_001348831.1"
/db_xref="GeneID:850525"
CDS complement(100252..100605)
/locus_tag="YFL019C"
/note="hypothetical protein; conserved across S.
cerevisiae strains; YFL019C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335772.1"
/db_xref="GeneID:850525"
/db_xref="SGD:S000001875"
/translation="MIVELYSNIIEVRRYTTKDSLCSIFESGSTSHFEINQLQVKRLN
LLQNQFASVFTSFHPKDNTKGIHINFFSPVTRITDLQYSFFYTNQILFGTRYLIKMIQ
NFVTGKVFTRTNQSK"
repeat_region 100581..100901
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006924"
gene 101376..101478
/gene="SUF9"
/locus_tag="YNCF0002W"
/db_xref="GeneID:850526"
tRNA join(101376..101411,101443..101478)
/gene="SUF9"
/locus_tag="YNCF0002W"
/product="tRNA-Pro"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Proline tRNA (tRNA-Pro), predicted by tRNAscan-SE
analysis; can mutate to suppress +1 frameshift mutations
in proline codons"
/db_xref="GeneID:850526"
/db_xref="SGD:S000006681"
gene complement(<101628..>103127)
/gene="LPD1"
/locus_tag="YFL018C"
/gene_synonym="HPD1"
/db_xref="GeneID:850527"
mRNA complement(<101628..>103127)
/gene="LPD1"
/locus_tag="YFL018C"
/gene_synonym="HPD1"
/product="dihydrolipoyl dehydrogenase"
/transcript_id="NM_001179948.1"
/db_xref="GeneID:850527"
CDS complement(101628..103127)
/gene="LPD1"
/locus_tag="YFL018C"
/gene_synonym="HPD1"
/EC_number="1.8.1.4"
/experiment="EXISTENCE:direct assay:GO:0004148
dihydrolipoyl dehydrogenase activity [PMID:2821168]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005967
mitochondrial pyruvate dehydrogenase complex
[PMID:12756305]"
/experiment="EXISTENCE:direct assay:GO:0009353
mitochondrial oxoglutarate dehydrogenase complex
[PMID:2072900]"
/experiment="EXISTENCE:direct assay:GO:0042645
mitochondrial nucleoid [PMID:10869431|PMID:11926067]"
/experiment="EXISTENCE:genetic interaction:GO:0042743
hydrogen peroxide metabolic process [PMID:17110466]"
/experiment="EXISTENCE:mutant phenotype:GO:0004375 glycine
dehydrogenase (decarboxylating) activity [PMID:7498764]"
/experiment="EXISTENCE:mutant phenotype:GO:0004591
oxoglutarate dehydrogenase (succinyl-transferring)
activity [PMID:3528755]"
/experiment="EXISTENCE:mutant phenotype:GO:0004738
pyruvate dehydrogenase activity [PMID:3528755]"
/experiment="EXISTENCE:mutant phenotype:GO:0005960 glycine
cleavage complex [PMID:7498764]"
/experiment="EXISTENCE:mutant phenotype:GO:0006090
pyruvate metabolic process [PMID:3528755]"
/experiment="EXISTENCE:mutant phenotype:GO:0006103
2-oxoglutarate metabolic process [PMID:3528755]"
/experiment="EXISTENCE:mutant phenotype:GO:0006546 glycine
catabolic process [PMID:7498764]"
/experiment="EXISTENCE:mutant phenotype:GO:0006550
isoleucine catabolic process [PMID:1479341]"
/experiment="EXISTENCE:mutant phenotype:GO:0006552 leucine
catabolic process [PMID:1479341]"
/experiment="EXISTENCE:mutant phenotype:GO:0006564
L-serine biosynthetic process [PMID:7498764]"
/experiment="EXISTENCE:mutant phenotype:GO:0006574 valine
catabolic process [PMID:1479341]"
/experiment="EXISTENCE:mutant phenotype:GO:0042743
hydrogen peroxide metabolic process [PMID:17110466]"
/note="Dihydrolipoamide dehydrogenase; the lipoamide
dehydrogenase component (E3) of the pyruvate dehydrogenase
and 2-oxoglutarate dehydrogenase multi-enzyme complexes;
PDH complex is concentrated in spots within the
mitochondrial matrix, often near the ERMES complex and
near peroxisomes; LPD1 has a paralog, IRC15, that arose
from the whole genome duplication"
/codon_start=1
/product="dihydrolipoyl dehydrogenase"
/protein_id="NP_116635.1"
/db_xref="GeneID:850527"
/db_xref="SGD:S000001876"
/translation="MLRIRSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIK
AAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIK
INVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVK
EDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLE
MGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDD
KNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQF
NSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAW
VGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPN
AGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC"
gene <103699..>103932
/gene="SMX2"
/locus_tag="YFL017W-A"
/gene_synonym="SNP2; YFL018W-A"
/db_xref="GeneID:850528"
mRNA <103699..>103932
/gene="SMX2"
/locus_tag="YFL017W-A"
/gene_synonym="SNP2; YFL018W-A"
/product="mRNA splicing protein SMX2"
/transcript_id="NM_001180864.1"
/db_xref="GeneID:850528"
CDS 103699..103932
/gene="SMX2"
/locus_tag="YFL017W-A"
/gene_synonym="SNP2; YFL018W-A"
/experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP
[PMID:11720284|PMID:11720285]"
/experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP
[PMID:9012791|PMID:9630245]"
/experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5
tri-snRNP complex [PMID:10377396|PMID:10449419]"
/experiment="EXISTENCE:direct assay:GO:0071004 U2-type
prespliceosome [PMID:16618970]"
/note="Core Sm protein Sm G; part of heteroheptameric
complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and
Smx3p) that is part of the spliceosomal U1, U2, U4, and U5
snRNPs; homolog of human Sm G"
/codon_start=1
/product="mRNA splicing protein SMX2"
/protein_id="NP_116636.1"
/db_xref="GeneID:850528"
/db_xref="SGD:S000002965"
/translation="MVSTPELKKYMDKKILLNINGSRKVAGILRGYDIFLNVVLDDAM
EINGEDPANNHQLGLQTVIRGNSIISLEALDAI"
gene complement(<103983..>104462)
/gene="GNA1"
/locus_tag="YFL017C"
/gene_synonym="PAT1"
/db_xref="GeneID:850529"
mRNA complement(<103983..>104462)
/gene="GNA1"
/locus_tag="YFL017C"
/gene_synonym="PAT1"
/product="glucosamine 6-phosphate N-acetyltransferase"
/transcript_id="NM_001179949.1"
/db_xref="GeneID:850529"
CDS complement(103983..104462)
/gene="GNA1"
/locus_tag="YFL017C"
/gene_synonym="PAT1"
/EC_number="2.3.1.4"
/experiment="EXISTENCE:direct assay:GO:0004343 glucosamine
6-phosphate N-acetyltransferase activity [PMID:9867860]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0006048
UDP-N-acetylglucosamine biosynthetic process
[PMID:9867860]"
/experiment="EXISTENCE:mutant phenotype:GO:0006048
UDP-N-acetylglucosamine biosynthetic process
[PMID:9867860]"
/note="Glucosamine-6-phosphate acetyltransferase;
evolutionarily conserved; required for multiple cell cycle
events including passage through START, DNA synthesis, and
mitosis; involved in UDP-N-acetylglucosamine synthesis,
forms GlcNAc6P from AcCoA"
/codon_start=1
/product="glucosamine 6-phosphate N-acetyltransferase"
/protein_id="NP_116637.1"
/db_xref="GeneID:850529"
/db_xref="SGD:S000001877"
/translation="MSLPDGFYIRRMEEGDLEQVTETLKVLTTVGTITPESFSKLIKY
WNEATVWNDNEDKKIMQYNPMVIVDKRTETVAATGNIIIERKIIHELGLCGHIEDIAV
NSKYQGQGLGKLLIDQLVTIGFDYGCYKIILDCDEKNVKFYEKCGFSNAGVEMQIRK"
rep_origin 104463..104701
/note="ARS603.1; Very weak autonomously replicating
sequence"
/db_xref="SGD:S000178095"
gene complement(<104701..>106236)
/gene="MDJ1"
/locus_tag="YFL016C"
/db_xref="GeneID:850530"
mRNA complement(<104701..>106236)
/gene="MDJ1"
/locus_tag="YFL016C"
/product="Mdj1p"
/transcript_id="NM_001179950.1"
/db_xref="GeneID:850530"
CDS complement(104701..106236)
/gene="MDJ1"
/locus_tag="YFL016C"
/experiment="EXISTENCE:direct assay:GO:0001671 ATPase
activator activity [PMID:9973563]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005759
mitochondrial matrix [PMID:15383543]"
/experiment="EXISTENCE:direct assay:GO:0042026 protein
refolding [PMID:9973563]"
/experiment="EXISTENCE:mutant phenotype:GO:0000002
mitochondrial genome maintenance [PMID:10567545]"
/experiment="EXISTENCE:mutant phenotype:GO:0006458 'de
novo' protein folding [PMID:8168133]"
/experiment="EXISTENCE:mutant phenotype:GO:0006515 protein
quality control for misfolded or incompletely synthesized
proteins [PMID:7957078]"
/experiment="EXISTENCE:mutant phenotype:GO:0009408
response to heat [PMID:8603724]"
/experiment="EXISTENCE:mutant phenotype:GO:0042026 protein
refolding [PMID:8168133]"
/experiment="EXISTENCE:mutant phenotype:GO:0051082
unfolded protein binding [PMID:8943361]"
/note="Co-chaperone that stimulates HSP70 protein Ssc1p
ATPase activity; involved in protein folding/refolding in
the mitochodrial matrix; required for proteolysis of
misfolded proteins; member of the HSP40 (DnaJ) family of
chaperones"
/codon_start=1
/product="Mdj1p"
/protein_id="NP_116638.1"
/db_xref="GeneID:850530"
/db_xref="SGD:S000001878"
/translation="MAFQQGVLSRCSGVFRHHVGHSRHINNILYRHAIAFASIAPRIP
KSSFHTSAIRNNEAFKDPYDTLGLKKSATGAEIKKAYYKLAKKYHPDINKEPDAEKKF
HDLQNAYEILSDETKRQQYDQFGPAAFGGGGAAGGAGGGSGSPFGSQFHDFSGFTSAG
GSPFGGINFEDLFGAAFGGGGRGSGGASRSSSMFRQYRGDPIEIVHKVSFKDAVFGSK
NVQLRFSALDPCSTCSGTGMKPNTHKVSCSTCHGTGTTVHIRGGFQMMSTCPTCNGEG
TMKRPQDNCTKCHGEGVQVNRAKTITVDLPHGLQDGDVVRIPGQGSYPDIAVEADLKD
SVKLSRGDILVRIRVDKDPNFSIKNKYDIWYDKEIPITTAALGGTVTIPTVEGQKIRI
KVAPGTQYNQVISIPNMGVPKTSTIRGDMKVQYKIVVKKPQSLAEKCLWEALADVTND
DMAKKTMQPGTAAGTAINEEILKKQKQEEEKHAKKDDDNTLKRLENFITNTFRKIKGD
KKN"
gene complement(<106469..>106963)
/locus_tag="YFL015C"
/db_xref="GeneID:850531"
mRNA complement(<106469..>106963)
/locus_tag="YFL015C"
/product="uncharacterized protein"
/transcript_id="NM_001348832.1"
/db_xref="GeneID:850531"
CDS complement(106469..106963)
/locus_tag="YFL015C"
/note="hypothetical protein; conserved across S.
cerevisiae strains; partially overlaps dubious ORF
YFL015W-A; YFL015C is not an essential gene"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335773.1"
/db_xref="GeneID:850531"
/db_xref="SGD:S000001879"
/translation="MLAYTFPSFNFYVNGFFSFLFLFLFLFPSLLRFYVILCRPLQVA
TYPLNRCQQYSSLAIFTASGFWLLVLVPRAKGPSTRRHCYRQLAPTHHRPFFSIFGWA
VSGIRPLPEIFTWICASPFFLHSLTPPTFSHFSVYQEEKKEKRRTPKNTEQEGNRMCI
WMSG"
gene <107256..>107585
/gene="HSP12"
/locus_tag="YFL014W"
/gene_synonym="GLP1; HOR5"
/db_xref="GeneID:850532"
mRNA <107256..>107585
/gene="HSP12"
/locus_tag="YFL014W"
/gene_synonym="GLP1; HOR5"
/product="lipid-binding protein HSP12"
/transcript_id="NM_001179952.1"
/db_xref="GeneID:850532"
CDS 107256..107585
/gene="HSP12"
/locus_tag="YFL014W"
/gene_synonym="GLP1; HOR5"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005768 endosome
[PMID:20797624]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:20797624]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:10675505|PMID:16622836|PMID:20797624]"
/experiment="EXISTENCE:direct assay:GO:0007155 cell
adhesion [PMID:11816034]"
/experiment="EXISTENCE:direct assay:GO:0008289 lipid
binding [PMID:20797624]"
/experiment="EXISTENCE:mutant phenotype:GO:0007009 plasma
membrane organization [PMID:20797624]"
/experiment="EXISTENCE:mutant phenotype:GO:0034599
cellular response to oxidative stress [PMID:20797624]"
/experiment="EXISTENCE:mutant phenotype:GO:0034605
cellular response to heat [PMID:20797624]"
/experiment="EXISTENCE:mutant phenotype:GO:0071470
cellular response to osmotic stress [PMID:20797624]"
/note="Plasma membrane protein involved in maintaining
membrane organization; involved in maintaining
organization during stress conditions; induced by heat
shock, oxidative stress, osmostress, stationary phase,
glucose depletion, oleate and alcohol; protein abundance
increased in response to DNA replication stress and
dietary restriction; regulated by the HOG and Ras-Pka
pathways; required for dietary restriction-induced
lifespan extension"
/codon_start=1
/product="lipid-binding protein HSP12"
/protein_id="NP_116640.1"
/db_xref="GeneID:850532"
/db_xref="SGD:S000001880"
/translation="MSDAGRKGFGEKASEALKPDSQKSYAEQGKEYITDKADKVAGKV
QPEDNKGVFQGVHDSAEKGKDNAEGQGESLADQARDYMGAAKSKLNDAVEYVSGRVHG
EEDPTKK"
gene complement(<107852..>109930)
/gene="IES1"
/locus_tag="YFL013C"
/db_xref="GeneID:850534"
mRNA complement(<107852..>109930)
/gene="IES1"
/locus_tag="YFL013C"
/product="Ies1p"
/transcript_id="NM_001179953.1"
/db_xref="GeneID:850534"
CDS complement(107852..109930)
/gene="IES1"
/locus_tag="YFL013C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095|PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0006338 chromatin
remodeling [PMID:12887900]"
/experiment="EXISTENCE:direct assay:GO:0031011 Ino80
complex [PMID:12887900]"
/experiment="EXISTENCE:physical interaction:GO:0031011
Ino80 complex [PMID:24034245]"
/note="Subunit of the INO80 chromatin remodeling complex;
relocalizes to the cytosol in response to hypoxia"
/codon_start=1
/product="Ies1p"
/protein_id="NP_116641.1"
/db_xref="GeneID:850534"
/db_xref="SGD:S000001881"
/translation="MGKRVYDPIHDTFQLREDNSDETKADSPMQSVKSGSQEEASPSS
IQSETETVTTKSIPVIHEIEIDDKNDDDSTQSEEENTNILLNFEPSTVPEATGASTAT
GPVTTNTVRRKPKESNASKYNRHLKKPDGEPFNRKDIQFSFMQELLMDKRQIFTNVLK
PLYKNSIVPINIDGDKLSINVTDKEYDARTFVFNDKLTFAQLYVLTIATSIKCSKILR
DKLLLDQQVAFSTCVLALLVNIGRLNTTINFYLEMTSQLRTFHSVPVLQLHANDPKLL
QDTPRLKSILKNLPWGNEQLSLMETYKKVDQNDGEVDTVNKFNIINMLFSICDNSGLI
DKRFLSKYVEVESKAQEQDMVDEQNEVKETEAENEKQESKAAYATTLFDILDYSKYEP
KDRSNILIWLLYIHLETNLSQEEVEESVRFFNGLEDGAPAGKFILRCTERSYDTDPED
ELEFGANQRIKRREFMSKMEEGRKRERTNVTEVKKPSIGGDKSEEDGEGEDDKSEETV
EETRSLLTPTPILESSSPMTLNRKKVTPQLPKVTPAAPTETEEEITSAAIIDKNDLNL
TPLKKYNSSATVNKVDKLISLDLNKHVSENGKTQEEFLADLKKSQVPNRLKRRDIGLI
KIFNEFEDIPVASVLGIRGKKRKKFKDNLLGFETDFMKNLGASKKVLLNKIERAEIDD
EEATAMFKLE"
gene <110647..>111093
/locus_tag="YFL012W"
/db_xref="GeneID:850535"
mRNA <110647..>111093
/locus_tag="YFL012W"
/product="uncharacterized protein"
/transcript_id="NM_001179954.1"
/db_xref="GeneID:850535"
CDS 110647..111093
/locus_tag="YFL012W"
/note="hypothetical protein; transcribed during
sporulation; null mutant exhibits increased resistance to
rapamycin"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116643.1"
/db_xref="GeneID:850535"
/db_xref="SGD:S000001882"
/translation="MPKSRPKRTIASSSSVFYGSSPFQNDGYIKVMELVSHIVIEINH
SPTATTDETRKQNNPELKVKEPVCNLKKWENNTNFILEDHTKNKTKLSSTDRIRKWFR
RHILKEEIEILSHGKQLSSIDEDYCPSNVLVGCSRDLNKLRSFQNF"
gene <112345..>113985
/gene="HXT10"
/locus_tag="YFL011W"
/db_xref="GeneID:850536"
mRNA <112345..>113985
/gene="HXT10"
/locus_tag="YFL011W"
/product="hexose transporter HXT10"
/transcript_id="NM_001179955.1"
/db_xref="GeneID:850536"
CDS 112345..113985
/gene="HXT10"
/locus_tag="YFL011W"
/experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
vacuole [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0005353
fructose transmembrane transporter activity
[PMID:10618490]"
/experiment="EXISTENCE:mutant phenotype:GO:0005354
galactose transmembrane transporter activity
[PMID:10618490]"
/experiment="EXISTENCE:mutant phenotype:GO:0005355 glucose
transmembrane transporter activity [PMID:10618490]"
/experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose
transmembrane transport [PMID:10618490]"
/experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose
transmembrane transporter activity [PMID:10618490]"
/note="Hexose transporter; expressed at low levels and
expression is repressed by glucose"
/codon_start=1
/product="hexose transporter HXT10"
/protein_id="NP_116644.1"
/db_xref="GeneID:850536"
/db_xref="SGD:S000001883"
/translation="MVSSSVSILGTSAKASTSLSRKDEIKLTPETREASLDIPYKPII
AYWTVMGLCLMIAFGGFIFGWDTGTISGFINQTDFKRRFGELQRDGSFQLSDVRTGLI
VGIFNIGCALGGLTLGRLGDIYGRKIGLMCVILVYVVGIVIQIASSDKWYQYFIGRIV
SGMGVGGVAVLSPTLISEISPKHLRGTCVSFYQLMITLGIFLGYCTNYGTKKYSNSIQ
WRVPLGLCFAWAIFMVIGMVMVPESPRYLVEKGKYEEARRSLAKSNKVTVTDPGVVFE
FDTIVANMELERAVGNASWHELFSNKGAILPRVIMGIVIQSLQQLTGCNYFFYYGTTI
FNAVGMQDSFETSIVLGAVNFASTFVALYIVDKFGRRKCLLWGSASMAICFVIFATVG
VTRLWPQGKDQPSSQSAGNVMIVFTCFFIFSFAITWAPIAYVIVAETYPLRVKNRAMA
IAVGANWMWGFLIGFFTPFITRSIGFSYGYVFMGCLIFSYFYVFFFVCETKGLTLEEV
NEMYEERIKPWKSGGWIPSSRRTPQPTSSTPLVIVDSK"
gene <114990..>115274
/gene="AUA1"
/locus_tag="YFL010W-A"
/gene_synonym="YFL011W-A"
/db_xref="GeneID:850537"
mRNA <114990..>115274
/gene="AUA1"
/locus_tag="YFL010W-A"
/gene_synonym="YFL011W-A"
/product="Aua1p"
/transcript_id="NM_001180024.1"
/db_xref="GeneID:850537"
CDS 114990..115274
/gene="AUA1"
/locus_tag="YFL010W-A"
/gene_synonym="YFL011W-A"
/experiment="EXISTENCE:mutant phenotype:GO:0006865 amino
acid transport [PMID:8497191]"
/note="Protein required for the negative regulation by
ammonia of Gap1p; Gap1p is a general amino acid permease"
/codon_start=1
/product="Aua1p"
/protein_id="NP_116645.1"
/db_xref="GeneID:850537"
/db_xref="SGD:S000001955"
/translation="MDRSLQVYICMYPYLDGSKQYRFDELISFYRPCPKSLDNIKSHY
RQIHHQIRRRTHQHHQIRRRTHQHHHRSNCSRQRQCLVRHSCGRQMRVLA"
gene complement(<115108..>115743)
/gene="WWM1"
/locus_tag="YFL010C"
/db_xref="GeneID:850538"
mRNA complement(<115108..>115743)
/gene="WWM1"
/locus_tag="YFL010C"
/product="Wwm1p"
/transcript_id="NM_001179956.1"
/db_xref="GeneID:850538"
CDS complement(115108..115743)
/gene="WWM1"
/locus_tag="YFL010C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:12062425|PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/note="WW domain containing hypothetical protein; binds to
Mca1p, a caspase-related protease that regulates
H2O2-induced apoptosis; overexpression causes G1 phase
growth arrest and clonal death that is suppressed by
overexpression of MCA1"
/codon_start=1
/product="Wwm1p"
/protein_id="NP_570898.1"
/db_xref="GeneID:850538"
/db_xref="SGD:S000001884"
/translation="MAQSKSNPPQVPSGWKAVFDDEYQTWYYVDLSTNSSQWEPPRGT
TWPRPKGPPPGVNNEKSSRQQADQAPPPYSSQSTPQVQAGAQAQQPRYYQPQQPQYPQ
YPQQQRYYPQQAPMPAAAPQQAYYGTAPSTSKGSGHGGAMMGGLLGVGAGLLGGAMLE
HAFDDHNYDGPDTVVVENNYYGDDAGGSDGGFDDAGGFDGGFDDGFDGSDF"
gene <116145..>118484
/gene="CDC4"
/locus_tag="YFL009W"
/db_xref="GeneID:850539"
mRNA <116145..>118484
/gene="CDC4"
/locus_tag="YFL009W"
/product="SCF ubiquitin ligase complex subunit CDC4"
/transcript_id="NM_001179957.1"
/db_xref="GeneID:850539"
CDS 116145..118484
/gene="CDC4"
/locus_tag="YFL009W"
/experiment="EXISTENCE:direct assay:GO:0004842
ubiquitin-protein transferase activity [PMID:9346239]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11080155]"
/experiment="EXISTENCE:direct assay:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:9346238|PMID:9346239]"
/experiment="EXISTENCE:direct assay:GO:0016363 nuclear
matrix [PMID:2244914]"
/experiment="EXISTENCE:direct assay:GO:0016567 protein
ubiquitination [PMID:23645675]"
/experiment="EXISTENCE:direct assay:GO:0019005 SCF
ubiquitin ligase complex [PMID:9346238|PMID:9346239]"
/experiment="EXISTENCE:direct assay:GO:0031146
SCF-dependent proteasomal ubiquitin-dependent protein
catabolic process [PMID:9346238|PMID:9346239]"
/experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin
binding [PMID:21070969]"
/experiment="EXISTENCE:direct assay:GO:0043224 nuclear SCF
ubiquitin ligase complex [PMID:11080155]"
/experiment="EXISTENCE:direct assay:GO:0050815
phosphoserine residue binding [PMID:23314252]"
/experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin
protein ligase activity [PMID:9346238]"
/experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M
transition of mitotic cell cycle [PMID:7954792]"
/experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S
transition of mitotic cell cycle [PMID:10409741]"
/experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M
transition of mitotic cell cycle [PMID:10409741]"
/experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic
cell cycle [PMID:328339]"
/experiment="EXISTENCE:mutant phenotype:GO:0061630
ubiquitin protein ligase activity [PMID:21098119]"
/experiment="EXISTENCE:physical interaction:GO:0019005 SCF
ubiquitin ligase complex [PMID:9346238|PMID:9346239]"
/note="F-box protein required for both the G1/S and G2/M
phase transitions; modular substrate specificity factor
which associates with core SCF (Cdc53p, Skp1p and
Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as
a ubiquitin-protein ligase directing ubiquitination of
cyclin-dependent kinase (CDK) phosphorylated substrates,
such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p"
/codon_start=1
/product="SCF ubiquitin ligase complex subunit CDC4"
/protein_id="NP_116585.1"
/db_xref="GeneID:850539"
/db_xref="SGD:S000001885"
/translation="MGSFPLAEFPLRDIPVPYSYRVSGGIASSGSVTALVTAAGTHRN
SSTAKTVETEDGEEDIDEYQRKRAAGSGESTPERSDFKRVKHDNHKTLHPVNLQNTGA
ASVDNDGLHNLTDISNDAEKLLMSVDDGSAAPSTLSVNMGVASHNVAAPTTVNAATIT
GSDVSNNVNSATINNPMEEGALPLSPTASSPGTTTPLAKTTKTINNNNNIADLIESKD
SIISPEYLSDEIFSAINNNLPHAYFKNLLFRLVANMDRSELSDLGTLIKDNLKRDLIT
SLPFEISLKIFNYLQFEDIINSLGVSQNWNKIIRKSTSLWKKLLISENFVSPKGFNSL
NLKLSQKYPKLSQQDRLRLSFLENIFILKNWYNPKFVPQRTTLRGHMTSVITCLQFED
NYVITGADDKMIRVYDSINKKFLLQLSGHDGGVWALKYAHGGILVSGSTDRTVRVWDI
KKGCCTHVFKGHNSTVRCLDIVEYKNIKYIVTGSRDNTLHVWKLPKESSVPDHGEEHD
YPLVFHTPEENPYFVGVLRGHMASVRTVSGHGNIVVSGSYDNTLIVWDVAQMKCLYIL
SGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIWNNGECSYATNSASPCAKILGA
MYTLQGHTALVGLLRLSDKFLVSAAADGSIRGWDANDYSRKFSYHHTNLSAITTFYVS
DNILVSGSENQFNIYNLRSGKLVHANILKDADQIWSVNFKGKTLVAAVEKDGQSFLEI
LDFSKASKINYVSNPVNSSSSSLESISTSLGLTRTTIIP"
rep_origin 118637..118957
/note="ARS603.5; Autonomously replicating sequence on
Chromosome VI; activated early in S phase in
50% of cell cycles"
/db_xref="SGD:S000007645"
gene <119429..>123106
/gene="SMC1"
/locus_tag="YFL008W"
/gene_synonym="CHL10"
/db_xref="GeneID:850540"
mRNA <119429..>123106
/gene="SMC1"
/locus_tag="YFL008W"
/gene_synonym="CHL10"
/product="cohesin subunit SMC1"
/transcript_id="NM_001179958.1"
/db_xref="GeneID:850540"
CDS 119429..123106
/gene="SMC1"
/locus_tag="YFL008W"
/gene_synonym="CHL10"
/experiment="EXISTENCE:direct assay:GO:0000217 DNA
secondary structure binding [PMID:9727028]"
/experiment="EXISTENCE:direct assay:GO:0003680 minor
groove of adenine-thymine-rich DNA binding [PMID:9727028]"
/experiment="EXISTENCE:direct assay:GO:0003690
double-stranded DNA binding [PMID:9727028]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0030892 mitotic
cohesin complex [PMID:9990856]"
/experiment="EXISTENCE:genetic interaction:GO:0007064
mitotic sister chromatid cohesion [PMID:9335333]"
/experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic
sister chromatid segregation [PMID:8276886]"
/experiment="EXISTENCE:mutant phenotype:GO:0006302
double-strand break repair [PMID:11448778|PMID:15280507]"
/note="Subunit of the multiprotein cohesin complex;
essential protein involved in chromosome segregation and
in double-strand DNA break repair; SMC chromosomal ATPase
family member, binds DNA with a preference for DNA with
secondary structure"
/codon_start=1
/product="cohesin subunit SMC1"
/protein_id="NP_116647.1"
/db_xref="GeneID:850540"
/db_xref="SGD:S000001886"
/translation="MGRLVGLELSNFKSYRGVTKVGFGESNFTSIIGPNGSGKSNMMD
AISFVLGVRSNHLRSNILKDLIYRGVLNDENSDDYDNEGAASSNPQSAYVKAFYQKGN
KLVELMRIISRNGDTSYKIDGKTVSYKDYSIFLENENILIKAKNFLVFQGDVEQIAAQ
SPVELSRMFEEVSGSIQYKKEYEELKEKIEKLSKSATESIKNRRRIHGELKTYKEGIN
KNEEYRKQLDKKNELQKFQALWQLYHLEQQKEELTDKLSALNSEISSLKGKINNEMKS
LQRSKSSFVKESAVISKQKSKLDYIFKDKEKLVSDLRLIKVPQQAAGKRISHIEKRIE
SLQKDLQRQKTYVERFETQLKVVTRSKEAFEEEIKQSARNYDKFKLNENDLKTYNCLH
EKYLTEGGSILEEKIAVLNNDKREIQEELERFNKRADISKRRITEELSITGEKLDTQL
NDLRVSLNEKNALHTERLHELKKLQSDIESANNQEYDLNFKLRETLVKIDDLSANQRE
TMKERKLRENIAMLKRFFPGVKGLVHDLCHPKKEKYGLAVSTILGKNFDSVIVENLTV
AQECIAFLKKQRAGTASFIPLDTIETELPTLSLPDSQDYILSINAIDYEPEYEKAMQY
VCGDSIICNTLNIAKDLKWKKGIRGKLVTIEGALIHKAGLMTGGISGDANNRWDKEEY
QSLMSLKDKLLIQIDELSNGQRSNSIRAREVENSVSLLNSDIANLRTQVTQQKRSLDE
NRLEIKYHNDLIEKEIQPKITELKKKLDDLENTKDNLVKEKEALQNNIFKEFTSKIGF
TIKEYENHSGELMRQQSKELQQLQKQILTVENKLQFETDRLSTTQRRYEKAQKDLENA
QVEMKSLEEQEYAIEMKIGSIESKLEEHKNHLDELQKKFVTKQSELNSSEDILEDMNS
NLQVLKRERDGIKEDIEKFDLERVTALKNCKISNINIPISSETTIDDLPISSTDNEAI
TISNSIDINYKGLPKKYKENNTDSARKELEQKIHEVEEILNELQPNARALERYDEAEG
RFEVINNETEQLKAEEKKILNQFLKIKKKRKELFEKTFDYVSDHLDAIYRELTKNPNS
NVELAGGNASLTIEDEDEPFNAGIKYHATPPLKRFKDMEYLSGGEKTVAALALLFAIN
SYQPSPFFVLDEVDAALDITNVQRIAAYIRRHRNPDLQFIVISLKNTMFEKSDALVGV
YRQQQENSSKIITLDLSNYAE"
gene <123479..>129910
/gene="BLM10"
/locus_tag="YFL007W"
/gene_synonym="YFL006W"
/db_xref="GeneID:850541"
mRNA <123479..>129910
/gene="BLM10"
/locus_tag="YFL007W"
/gene_synonym="YFL006W"
/product="Blm10p"
/transcript_id="NM_001179959.1"
/db_xref="GeneID:850541"
CDS 123479..129910
/gene="BLM10"
/locus_tag="YFL007W"
/gene_synonym="YFL006W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:12973301|PMID:15778719|PMID:22908043]"
/experiment="EXISTENCE:direct assay:GO:0016504 peptidase
activator activity [PMID:22025621]"
/experiment="EXISTENCE:direct assay:GO:0034515 proteasome
storage granule [PMID:23982732]"
/experiment="EXISTENCE:direct assay:GO:0061136 regulation
of proteasomal protein catabolic process [PMID:22025621]"
/experiment="EXISTENCE:direct assay:GO:0070628 proteasome
binding [PMID:22025621]"
/experiment="EXISTENCE:genetic interaction:GO:0043248
proteasome assembly [PMID:17911101]"
/experiment="EXISTENCE:mutant phenotype:GO:0043248
proteasome assembly [PMID:12973301]"
/experiment="EXISTENCE:mutant phenotype:GO:0070628
proteasome binding [PMID:22025621]"
/experiment="EXISTENCE:mutant phenotype:GO:1902906
proteasome storage granule assembly [PMID:23982732]"
/experiment="EXISTENCE:mutant phenotype:GO:1990236
proteasome core complex import into nucleus
[PMID:23982732]"
/note="Proteasome activator; binds the core proteasome
(CP) and stimulates proteasome-mediated protein
degradation by inducing gate opening; required for
sequestering CP into proteasome storage granule (PSG)
during quiescent phase and for nuclear import of CP in
proliferating cells; required for resistance to bleomycin,
may be involved in protecting against oxidative damage;
similar to mammalian PA200"
/codon_start=1
/product="Blm10p"
/protein_id="NP_116648.2"
/db_xref="GeneID:850541"
/db_xref="SGD:S000001887"
/translation="MTANNDDDIKSPIPITNKTLSQLKRFERSPGRPSSSQGEIKRKK
SRLYAADGRPHSPLRARSATPTLQDQKLFNGMDSTSLLNERLQHYTLDYVSDRAQHMK
NIYDPSSRWFSRSVRPEFPIEEFLPYKTESHEDQAKYLCHVLVNLYIAISSLDIQGLI
SISSKDLADLKKEVDDLALKTDLFRLSNNTAENDLLGNDIADYDDAEGLEDELDEYFD
LAGPDFNATGKITAKSATIVNVNHWTNELKNCLHFDFPVALRKSLATVYYYLSLVQGQ
KVYRQMHVDMFERLVSLDDDRTNFTELLQKQGLLLDHQIMLNFLCEFLPYPDPDYARY
ELSSKEDLQLFRLLLKHAHNAKPFFDKSKESLLVDTMNFLLSSLAPSTMMAVMPIVTS
VVPYHYHIHSKIIDYFPFCYSIWSSVSANVAIDTHMYDFVGSISKDVHNKILSSEHEK
DVVGVEFGEFGIFTDDQMTFMFNRLQGHLRTDGQIHSYSRTVKPFVYAINGSKKDRFF
EKLVSLAKAIETFIHPSNNGFWTKPNAKFVHAFIKSYHGRVKYEEDICARGVTNGICL
TSFCHEEIVEIFLNIISLGSQNKNPDIANYYISCFAYLLELDPSNAYLIYDKILIDLY
DTLADQFINSRHRIISSLKQFTRVIRFIVMDKLYRVHITNVLSMLVSKLDMNDTNLTS
NLINGIVSIAAFIPIQDLTGEDDYISFESDTLPLVQQHFYHIKCGESSKTFRVDDELL
NNAFKASTTVFQSMLKVYVEKIFQLVDVDLEDSLVTKINQTTMILQESMDDKIFNYFA
SLLQRNFWSNDSFKEKDPNYELVTIPLAALVRRNNGLSKELVRTLLFHIKEQIKRGAG
SVRSTSEIQQRDVKLVLYLTALNDVLRQCHESLLEYSDELITFMKYLYDNVTNPPLDV
ITSIVIHSALATLCTTEITDCRLFPEDSKIPEKDRWGGLQFDPRRFDKQHLSFQWHVP
SSDEITLSISILESLSEYCINNVEELMKAPRHDSEYGDMIQKYVLVMTHTLSGSSLLF
DPDFNKYRTQSNLSYREKLILLKNIRENNCDPQELDIDIEQIRSGKDDEDYIESKDIE
AGLNAGVSDVVQLRDEFPDELIVDEEVVSEMPSGVNTPIAGTHGTDNSAMSSDLAFRD
LDIYTCNYYFGNTTEEKLQNPQYLQVHRVRARIGHFFHKLYVFLSTNFENNTNMFQIL
LHGLKVWFTDLGQETVFNEDPNAFIDVDFLENVQSLSHVNEPFTRTNFAIRANSLHQS
RVLLHSTNRKASKLENLLLVDIIQLATSLYPDIYKPAQGTLVHCMKQLVGSYGVVINK
IIPSLEKAIKDHDYMKIQVILNVLLIKKIHRKLMTDYKDIGRLIFLLIECCRVNELEI
GMYADKILTDIVIGIKIPSSVCVISDQAFLPLAPPDGTINLQVEAVKLAKKKKREYYL
SLLVDLQDKLLDKLDNEKDMGWKIRMFILRFVTQIQSNLESKPDKRAVFSIISQISTK
HPEIIHLVVKSLLSTCNKIISLSDYEYDITRAYKNEFNPSFVEILDTSTTSFPKTFTE
EMNNFDNPKYFIDLRAYVGWLCWGRLMYVMSPKALKLNLRENELEVLKTAGHLLTREF
LRDVTMNLVQDNETRGVFSSGNVSFFSLVILLISSGFCELNMSDLFELCESYYNKDDK
ASMIMSVEIVAGLVCGSKFMSVSDLDKRDTFIENFLAKCLDYELNHDAFEIWSTLAWW
LPAVVDLRRSKTFFCHFINADGMFDRESDAATHQTSKIYMLRSILMSMEFRAPDVGKL
FDELVFDHPYDQVRQAVAKLLTTLVQNQSNPSISDPTTLLEAERNDPDGLGLPLKSVP
EKVDAYIKKQFEIIKNLEDSVVGLNPQQFIKTDYFYRTSTIFYWIKEMARGPNKVLLV
PYLVDYVLPFLIGLVKHKDVCALASLDPVRLYAGLGYMPIRKNHVAAIVDYVCSSNVA
LSSNQTKLQLAFIQHFLSAELLQLTEEEKNKILEFVVSNLYNEQFVEVRVRAASILSD
IVHNWKEEQPLLSLIERFAKGLDVNKYTSKERQKLSKTDIKIHGNVLGLGAIISAFPY
VFPLPPWIPKQLSNLSSWARTSGMTGQAAKNTISEFKKVRADTWKFDRASFNTEELED
LEGVLWRSYYA"
rep_origin 127751..128071
/gene="BLM10"
/locus_tag="YFL007W"
/gene_synonym="YFL006W"
/note="ARS604; Extremely inefficient ARS on Chromosome VI"
/db_xref="SGD:S000007636"
gene <130334..>130981
/gene="SEC4"
/locus_tag="YFL005W"
/gene_synonym="SRO6"
/db_xref="GeneID:850543"
mRNA <130334..>130981
/gene="SEC4"
/locus_tag="YFL005W"
/gene_synonym="SRO6"
/product="Rab family GTPase SEC4"
/transcript_id="NM_001179961.1"
/db_xref="GeneID:850543"
CDS 130334..130981
/gene="SEC4"
/locus_tag="YFL005W"
/gene_synonym="SRO6"
/experiment="EXISTENCE:direct assay:GO:0000131 incipient
cellular bud site [PMID:9128251]"
/experiment="EXISTENCE:direct assay:GO:0003924 GTPase
activity [PMID:2111819]"
/experiment="EXISTENCE:direct assay:GO:0005525 GTP binding
[PMID:2111819]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005741
mitochondrial outer membrane [PMID:16407407]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:16622836]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0006887 exocytosis
[PMID:15772160]"
/experiment="EXISTENCE:direct assay:GO:0030133 transport
vesicle [PMID:23079598]"
/experiment="EXISTENCE:direct assay:GO:0031982 vesicle
[PMID:12456647]"
/experiment="EXISTENCE:direct assay:GO:0043332 mating
projection tip [PMID:22832273]"
/experiment="EXISTENCE:genetic interaction:GO:0006914
autophagy [PMID:20444978]"
/experiment="EXISTENCE:genetic interaction:GO:0007107
membrane addition at site of cytokinesis [PMID:12456647]"
/experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi
to plasma membrane transport [PMID:9017592]"
/experiment="EXISTENCE:mutant phenotype:GO:0006906 vesicle
fusion [PMID:9017592]"
/experiment="EXISTENCE:mutant phenotype:GO:0006914
autophagy [PMID:20444978]"
/experiment="EXISTENCE:mutant phenotype:GO:0007107
membrane addition at site of cytokinesis [PMID:12456647]"
/experiment="EXISTENCE:mutant phenotype:GO:0031321
ascospore-type prospore assembly [PMID:9425151]"
/note="Rab family GTPase; essential for vesicle-mediated
exocytic secretion and autophagy; associates with the
exocyst component Sec15p and may regulate polarized
delivery of transport vesicles to the exocyst at the
plasma membrane; exocyst association is negatively
regulated via phosphorylation by Cdc5p during cytokinesis"
/codon_start=1
/product="Rab family GTPase SEC4"
/protein_id="NP_116650.1"
/db_xref="GeneID:850543"
/db_xref="SGD:S000001889"
/translation="MSGLRTVSASSGNGKSYDSIMKILLIGDSGVGKSCLLVRFVEDK
FNPSFITTIGIDFKIKTVDINGKKVKLQLWDTAGQERFRTITTAYYRGAMGIILVYDV
TDERTFTNIKQWFKTVNEHANDEAQLLLVGNKSDMETRVVTADQGEALAKELGIPFIE
SSAKNDDNVNEIFFTLAKLIQEKIDSNKLVGVGNGKEGNISINSGSGNSSKSNCC"
gene complement(131061..131503)
/gene="RUF20"
/locus_tag="YNCF0003C"
/db_xref="GeneID:9164889"
ncRNA complement(131061..131503)
/ncRNA_class="other"
/gene="RUF20"
/locus_tag="YNCF0003C"
/product="RUF20"
/note="RNA of Unknown Function"
/transcript_id="NR_132173.1"
/db_xref="GeneID:9164889"
/db_xref="SGD:S000130127"
gene <131810..>134296
/gene="VTC2"
/locus_tag="YFL004W"
/gene_synonym="PHM1"
/db_xref="GeneID:850544"
mRNA <131810..>134296
/gene="VTC2"
/locus_tag="YFL004W"
/gene_synonym="PHM1"
/product="vacuolar transporter chaperone"
/transcript_id="NM_001179962.1"
/db_xref="GeneID:850544"
CDS 131810..134296
/gene="VTC2"
/locus_tag="YFL004W"
/gene_synonym="PHM1"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:11823419|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005516 calmodulin
binding [PMID:17079729]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:17079729]"
/experiment="EXISTENCE:direct assay:GO:0007034 vacuolar
transport [PMID:17079729]"
/experiment="EXISTENCE:direct assay:GO:0016237 lysosomal
microautophagy [PMID:17079729]"
/experiment="EXISTENCE:genetic interaction:GO:0006797
polyphosphate metabolic process [PMID:11102525]"
/experiment="EXISTENCE:mutant phenotype:GO:0006797
polyphosphate metabolic process [PMID:11102525]"
/experiment="EXISTENCE:mutant phenotype:GO:0007034
vacuolar transport [PMID:17079729]"
/experiment="EXISTENCE:mutant phenotype:GO:0008104 protein
localization [PMID:10480897]"
/experiment="EXISTENCE:mutant phenotype:GO:0016237
lysosomal microautophagy [PMID:17079729]"
/experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole
fusion, non-autophagic [PMID:11823419]"
/experiment="EXISTENCE:physical interaction:GO:0033254
vacuolar transporter chaperone complex [PMID:11823419]"
/note="Regulatory subunit of vacuolar transporter
chaperone (VTC) complex; involved in membrane trafficking,
vacuolar polyphosphate accumulation, microautophagy and
non-autophagic vacuolar fusion; important regulator of
substrate invagination from the vacuolar membrane;
targeted to vacuole via AP-3 pathway; VTC2 has a paralog,
VTC3, that arose from the whole genome duplication"
/codon_start=1
/product="vacuolar transporter chaperone"
/protein_id="NP_116651.1"
/db_xref="GeneID:850544"
/db_xref="SGD:S000001890"
/translation="MLFGVKLANEVYPPWKGSYINYEGLKKFLKEDSVKDGSNDKKAR
WDDSDESKFVEELDKELEKVYGFQLKKYNNLMERLSHLEKQTDTEAAIKALDADAFQR
VLEELLSESTELDNFKRLNFTGFAKIVKKHDKLYPKYPSVKSLLEVRLKELPSHSEEY
SPLLYRISFLYNILRSNFNTASEPLASASKFSSIVSNDIDMNFRSFKFWVHNDNLMEV
KTRILRHLPVLVYANVPSENDDLVNRFESDISNNDEIVGSSSSTSSVEHGLGARSFDP
LINTLYFDNEHFELYNDKLLKLNSAPTLRLRWTGQLSDKPDIFLEKKTLIEDEATGKS
EFDLTKLQLKQKFINGFIFEGDKKFKEQTLKKLKESGTAGRDLERLEEDFSEIQNFII
KNELQPVFRTVYTRTAFQIPGDDKIRVTIDSNIVFIKEDSFDRERPIRDPNTWHRTDI
DANVANPLKFLRGGEYAKFPYSVMEIKVKSSLDSSMSASSMISNVKLPKKHGQWLNDL
TNSHLVKEIPKFSIFVQGVASLYGDDEKLDILPFWLPDLETDIRQDPKQAYEEEKKKL
LKQKEIQKKIDGMRRLSNLKEPQHQAAVPVSQEENERITSQGDLEADGSSDEETEQEP
HSKRSKKVRRRKPKATFLRILAGRDPKLMGVDSEEEEIELPPGVKKPLNLLKNAGPVN
VEAKVWLANERTFNRWLSVTSLLSVLTFSIYNSVKKAEYPTLANYMAYVYFGLTIFCA
LWSYSIYMKRVDIIQQRSGQHLDAPLGPVLVSIVLFVTLVVNFVMAFRNAAKSRQELQ
IQNLEVPERIPEVLRPLQNYLFKLMGPSSD"
gene complement(<134521..>137157)
/gene="MSH4"
/locus_tag="YFL003C"
/db_xref="GeneID:850545"
mRNA complement(<134521..>137157)
/gene="MSH4"
/locus_tag="YFL003C"
/product="MutS family protein MSH4"
/transcript_id="NM_001179963.1"
/db_xref="GeneID:850545"
CDS complement(134521..137157)
/gene="MSH4"
/locus_tag="YFL003C"
/experiment="EXISTENCE:direct assay:GO:0000228 nuclear
chromosome [PMID:11454751]"
/experiment="EXISTENCE:direct assay:GO:0000400 four-way
junction DNA binding [PMID:30467025]"
/experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA
binding [PMID:30467025]"
/experiment="EXISTENCE:direct assay:GO:0003690
double-stranded DNA binding [PMID:30467025]"
/experiment="EXISTENCE:direct assay:GO:0062037 D-loop DNA
binding [PMID:30467025]"
/experiment="EXISTENCE:mutant phenotype:GO:0007131
reciprocal meiotic recombination
[PMID:11454751|PMID:18615017|PMID:7622037]"
/experiment="EXISTENCE:physical interaction:GO:0062128
MutSgamma complex [PMID:9374523]"
/note="Protein involved in meiotic recombination; required
for normal levels of crossing over, colocalizes with Zip2p
to discrete foci on meiotic chromosomes, has homology to
bacterial MutS protein"
/codon_start=1
/product="MutS family protein MSH4"
/protein_id="NP_116652.1"
/db_xref="GeneID:850545"
/db_xref="SGD:S000001891"
/translation="MSESNLSSFISTNYFNLRSAANSSNSISKPSTKKSIRNQKSPTN
ISSWALKKKTLQIAETTWENNEKDSTHSHYLMTGSMASRTATSLSRYSTNASLLGPSI
DCVLCCIYEVPRDISTRIGLCIINCNTGQMYLSDFMDSQIYIRVVHKLQIYQPTEILI
PSSSLAPTVSKLATMIKFNVAETVKIEEGSRKCFNSQDGLAAITKYLMDDTKKDLKIE
EIIDKTFALCAASAAISYMEEIISKSSRNLNAFRKLRIQFEGTENTMLIDSKTVRGLE
LVENKLDKNGISLWKFLDTTSTKMGQRSLRNSILQPLTDRGSIEMRLEALEELKANDD
LLQKLRLEMKSLPDLDKLFSRLLCINHSAIKPDQRINYVLLLKETLQSVKSLKDALND
QLIQSRLISETKKIFNNDAIMEIEKLINSCINEDCVWASSAIQLLNQRSYAVKSDSNG
LLDVSRQIYKEVKEEFFREVEDLTAKNKINLDHNYDSARGFYLRIKRQEFTDDVATLP
DVFISRTIKKNYIECTTLNIIKKNARLKEVMEEILLLSEETVDELLDKIATHISELFM
IAEAVAILDLVCSFTYNLKENNYTIPIFTNNLLIRDSRHPLLEKVLKNFVPNTISSTK
HSSSLQIITGCNMSGKSVYLKQVALICIMAQMGSGIPALYGSFPVFKRLHARVCNDSM
ELTSSNFGFEMKEMAYFLDDINTETLLILDELGRGSSIADGFCVSLAVTEHLLRTEAT
VFLSTHFQDIPKIMSKKPAVSHLHMDAVLLNDNSVKMNYQLTQKSVAIENSGIRVVKK
IFNPDIIAEAYNIHSLLKIAKARTENEDSNGVVDQKTINQMKRIHNLVAILKECAGNE
KEPLTLGKLKEINSDFIENFEE"
rep_origin 135985..136085
/note="ARS605; Autonomously replicating sequence on
Chromosome VI; activated early in S phase in
27% of cell cycles; inactive during premeiotic S phase"
/db_xref="SGD:S000007637"
gene complement(137486..137559)
/locus_tag="YNCF0004C"
/db_xref="GeneID:850546"
tRNA complement(137486..137559)
/locus_tag="YNCF0004C"
/product="tRNA-Asn"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Asparagine tRNA (tRNA-Asn), predicted by
tRNAscan-SE analysis"
/db_xref="GeneID:850546"
/db_xref="SGD:S000006669"
repeat_region 137663..137912
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006925"
mobile_element 137913..143871
/note="YFLWTy2-1; Ty2 element, LTR retrotransposon of the
Copia (Pseudoviridae) group; contains co-transcribed genes
TYA Gag and TYB Pol, encoding proteins involved in
structure and function of virus-like particles, flanked by
two direct repeats"
/mobile_element_type="retrotransposon:YFLWTy2-1"
/db_xref="SGD:S000006930"
repeat_region 137913..138240
/note="Ty2 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006926"
gene <138204..>143517
/locus_tag="YFL002W-A"
/db_xref="GeneID:850548"
mRNA <138204..>143517
/locus_tag="YFL002W-A"
/product="gag-pol fusion protein"
/transcript_id="NM_001180862.2"
/db_xref="GeneID:850548"
CDS join(138204..139496,139498..143517)
/locus_tag="YFL002W-A"
/EC_number="2.7.7.7"
/EC_number="2.7.7.49"
/EC_number="3.1.26.4"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9448009]"
/ribosomal_slippage
/note="Retrotransposon TYA Gag and TYB Pol genes;
transcribed/translated as one unit; polyprotein is
processed to make a nucleocapsid-like protein (Gag),
reverse transcriptase (RT), protease (PR), and integrase
(IN); similar to retroviral genes"
/codon_start=1
/product="gag-pol fusion protein"
/protein_id="NP_116653.1"
/db_xref="GeneID:850548"
/db_xref="SGD:S000002962"
/translation="MESQQLHQNPHSLHGSAYASVTSKEVPSNQDPLAVSASNLPEFD
RDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWA
HYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAETK
VRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKSQMTYEEHAYIYN
TFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGS
TSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQ
LFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPR
AAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLGQQQKESKPTHTIDSNDEL
PDHLLIDSGASQTLVRSAHYLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKT
SIKALHTPNIAYDLLSLSELANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKY
LIPSHISKLTINNVNKSKSVNKYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIE
WSNASTYQCPDCLIGKSTKHRHVKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSY
FISFTDEKTRFQWVYPLHDRREESILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNK
TLHKFFTNRGITACYTTTADSRAHGVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEF
STIIRNSLVSPKNDKSARQHAGLAGLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYA
LHPSRNSYGYIIYLPSLKKTVDTTNYVILQDKQSKLDQFNYDTLTFDDDLNRLTAHNQ
SFIEQNETEQSYDQNTESDHDYQSEIEINSDPLVNDFSSQSINPLQLDKEPVQKVRAP
KEVDADISEYNILPSTIRSRTPHIINKESTEMGGTVESDTTSPRHSSTFTARNQNRPG
STNEMIDLTSQDRVNYGLENIKTTRLGGTEEPYIQRNSDTNIKYRTTNSTPSIDDRSS
NSESTTPIISIETKAVCDNTPSIDTDPPEYRSSDHATPNIMPDKSSKNVTADSILDDL
PLPDLTHKSPTDTSDVSKDIPHIHSRQTNSSLGGMDDSNVLTTTKSKKRSLEDNETEI
EVSRDTWNNKNMRSLEPPRSKKRINLIAAIKGVKSIKPVRTTLRYDEAITYNKDNKEK
DRYVEAYHKEISQLLKMNTWDTNKYYDRNDIDPKKVINSMFIFNKKRDGTHKARFVAR
GDIQHPDTYDSDMQSNTVHHYALMTSLSIALDNDYYITQLDISSAYLYADIKEELYIR
PPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKSYLINCCDMQEVRGWSCVFKNSQVT
ICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESDNEIQYDILGLEIKYQRSK
YMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGHYIDQDELEIDEDEYKEKVHEMQ
KLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYELIQFMWDTRDKQLIWHK
NKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKVIGGKSTKASLTCTSTTEAEI
HAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISIIKSTNEEKFRNRFFGTKAM
RLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH"
gene <138204..>139520
/locus_tag="YFL002W-B"
/db_xref="GeneID:850547"
mRNA <138204..>139520
/locus_tag="YFL002W-B"
/product="gag protein"
/transcript_id="NM_001184430.1"
/db_xref="GeneID:850547"
CDS 138204..139520
/locus_tag="YFL002W-B"
/note="Retrotransposon TYA Gag gene co-transcribed with
TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is
a nucleocapsid protein that is the structural constituent
of virus-like particles (VLPs); similar to retroviral Gag"
/codon_start=1
/product="gag protein"
/protein_id="NP_058157.1"
/db_xref="GeneID:850547"
/db_xref="SGD:S000007404"
/translation="MESQQLHQNPHSLHGSAYASVTSKEVPSNQDPLAVSASNLPEFD
RDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWA
HYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAETK
VRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKSQMTYEEHAYIYN
TFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGS
TSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQ
LFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYHRTNSSKPR
AAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLRPATERI"
repeat_region 143540..143871
/note="Ty2 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006927"
repeat_region 143872..143947
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006928"
repeat_region 144203..144523
/note="Ty4 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006929"
repeat_region complement(144524..144822)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006923"
gene complement(<145114..>146934)
/gene="SPB4"
/locus_tag="YFL002C"
/db_xref="GeneID:850549"
mRNA complement(<145114..>146934)
/gene="SPB4"
/locus_tag="YFL002C"
/product="putative ATP-dependent RNA helicase SPB4"
/transcript_id="NM_001179964.1"
/db_xref="GeneID:850549"
CDS complement(145114..146934)
/gene="SPB4"
/locus_tag="YFL002C"
/EC_number="3.6.4.13"
/experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm
[PMID:9769101]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:14562095|PMID:9769101]"
/experiment="EXISTENCE:direct assay:GO:0030686 90S
preribosome [PMID:21825077]"
/experiment="EXISTENCE:direct assay:GO:0030687
preribosome, large subunit precursor [PMID:22735702]"
/experiment="EXISTENCE:mutant phenotype:GO:0000027
ribosomal large subunit assembly
[PMID:21825077|PMID:2408148]"
/experiment="EXISTENCE:mutant phenotype:GO:0000470
maturation of LSU-rRNA [PMID:2408148]"
/experiment="EXISTENCE:mutant phenotype:GO:1902626
assembly of large subunit precursor of preribosome
[PMID:22735702]"
/experiment="EXISTENCE:physical interaction:GO:0030686 90S
preribosome [PMID:21825077]"
/note="Putative ATP-dependent RNA helicase; nucleolar
protein required for synthesis of 60S ribosomal subunits
at a late step in the pathway; sediments with 66S
pre-ribosomes in sucrose gradients"
/codon_start=1
/product="putative ATP-dependent RNA helicase SPB4"
/protein_id="NP_116654.1"
/db_xref="GeneID:850549"
/db_xref="SGD:S000001894"
/translation="MSKSLEWDNLGFSLLPWIRTGLDVMGFETMTPVQASTIPMLAGN
KDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFKKAHFHSLIIAPTRELSRQIESV
VLSFLEHYPSDLFPIKCQLLVGTNEATVRDDVSNFLRNRPQILIGTPGRVLDFLQMPA
VKTSACSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSAGSDIFKTGL
RNPVRITVNSKNQAPSSLKLNYCVVNPAEKLQLLVSILNNYKFKKCIVYFPTCVSVSY
FYSFIQYLGKRNILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLFTTDVAARGI
DIPDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVE
LEELDLEVKGITTNFYEDFRNWILEDRDRFDKGVKAYVAFIKYYSNHSATSIFRLQSL
DYVGIAKLYGLFRLPRMPEITKYLATEKQEGIFPGNWLVDPPVNMDEYKYKDKKREKE
RQETLKNISLINDKKKLKSELKKKNLAWSDKTLTKERKLERKEKMSLKRKAIEEELKA
EELDENAEEERIKEDWKEIVLQNKRKKVSSKAIQGNFDDL"
gene <147131..>148459
/gene="DEG1"
/locus_tag="YFL001W"
/gene_synonym="HRM3; PUS3"
/db_xref="GeneID:850550"
mRNA <147131..>148459
/gene="DEG1"
/locus_tag="YFL001W"
/gene_synonym="HRM3; PUS3"
/product="pseudouridine synthase DEG1"
/transcript_id="NM_001179965.1"
/db_xref="GeneID:850550"
CDS 147131..148459
/gene="DEG1"
/locus_tag="YFL001W"
/gene_synonym="HRM3; PUS3"
/EC_number="5.4.99.45"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:9430663]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:9430663]"
/experiment="EXISTENCE:direct assay:GO:0009982
pseudouridine synthase activity [PMID:9430663]"
/experiment="EXISTENCE:direct assay:GO:0031119 tRNA
pseudouridine synthesis [PMID:9430663]"
/experiment="EXISTENCE:mutant phenotype:GO:0009982
pseudouridine synthase activity [PMID:9430663]"
/experiment="EXISTENCE:mutant phenotype:GO:0031119 tRNA
pseudouridine synthesis [PMID:9430663]"
/experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA
pseudouridine synthesis [PMID:25192136]"
/note="tRNA:pseudouridine synthase; introduces
pseudouridines at position 38 or 39 in tRNA; also
responsible for pseudouracil modification of some mRNAs;
important for maintenance of translation efficiency and
normal cell growth, localizes to both the nucleus and
cytoplasm; non-essential for viability"
/codon_start=1
/product="pseudouridine synthase DEG1"
/protein_id="NP_116655.1"
/db_xref="GeneID:850550"
/db_xref="SGD:S000001895"
/translation="MSNFIRRLVGKMKAISTGTNAIVSKKDSIYANWSKEQLIRRITE
LENANKPHSEKFQHIEDNKKRKISQEEVTRSKAKKAPKKFDFSKHNTRFIALRFAYLG
WNYNGLAVQKEYTPLPTVEGTILEAMNKCKLVPSMVLQDYKFSRCGRTDKGVSAMNQV
ISLEVRSNLTDEEQRDPTNDSREIPYVHVLNQLLPDDIRISAVCLRPPPNFDARFSCV
HRHYKYIFNGKNLNIEKMSKAASYFVGERDFRNFCKLDGSKQITNFKRTIISSKILPL
SETFYCFDLVGSAFLWHQVRCMMAILFLVGQSLEVPEIVLRLTDIEKTPQRPVYEMAN
DIPLLLYDCKFPEMDWQEPTVDDYKAIKFTTATEALTLHYELKAAVCNIFKDVLPTAN
TNNFSKTIINLGDGRGKVVGTYVKLEDRSVMEPVEVVNAKYSKKKNNKNK"
centromere 148510..148627
/note="CEN6; Chromosome VI centromere"
/db_xref="SGD:S000001896"
centromere 148510..148519
/note="CEN6_CDEI of CEN6"
centromere 148520..148602
/note="CEN6_CDEII of CEN6"
centromere 148603..148627
/note="CEN6_CDEIII of CEN6"
gene <149110..>149724
/gene="LOC1"
/locus_tag="YFR001W"
/db_xref="GeneID:850551"
mRNA <149110..>149724
/gene="LOC1"
/locus_tag="YFR001W"
/product="Loc1p"
/transcript_id="NM_001179966.1"
/db_xref="GeneID:850551"
CDS 149110..149724
/gene="LOC1"
/locus_tag="YFR001W"
/experiment="EXISTENCE:direct assay:GO:0003729 mRNA
binding [PMID:11309412]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:16871394]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0017148 negative
regulation of translation [PMID:31323064]"
/experiment="EXISTENCE:direct assay:GO:0030687
preribosome, large subunit precursor
[PMID:11583614|PMID:27458021|PMID:17443350|PMID:23212245]"
/experiment="EXISTENCE:mutant phenotype:GO:0000055
ribosomal large subunit export from nucleus
[PMID:16871394]"
/experiment="EXISTENCE:mutant phenotype:GO:0000447
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from
5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript
(SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16871394]"
/experiment="EXISTENCE:mutant phenotype:GO:0000472
endonucleolytic cleavage to generate mature 5'-end of
SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
[PMID:16871394]"
/experiment="EXISTENCE:mutant phenotype:GO:0000480
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA
transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
[PMID:16871394]"
/experiment="EXISTENCE:mutant phenotype:GO:0008298
intracellular mRNA localization [PMID:11309412]"
/experiment="EXISTENCE:mutant phenotype:GO:0042273
ribosomal large subunit biogenesis
[PMID:11583614|PMID:27458021|PMID:31779129]"
/experiment="EXISTENCE:mutant phenotype:GO:0101031 protein
folding chaperone complex [PMID:31779129]"
/experiment="EXISTENCE:physical interaction:GO:0042273
ribosomal large subunit biogenesis [PMID:11583614]"
/note="Nucleolar protein involved in the asymmetric
localization of ASH1 mRNA; binds cooperatively with She2p
to the E3 zip-code element in the 3'-UTR of the mRNA;
constituent of 66S pre-ribosomal particles involved in
pre-rRNA processing and nuclear export of the 60S subunit;
may facilitate Rpl43p loading; required
post-transcriptionally for efficient retrotransposition;
absence results in decreased Ty1 Gag:GFP protein levels;
relocalizes from nucleus to cytoplasm upon DNA replication
stress"
/codon_start=1
/product="Loc1p"
/protein_id="NP_116656.1"
/db_xref="GeneID:850551"
/db_xref="SGD:S000001897"
/translation="MAPKKPSKRQNLRREVAPEVFQDSQARNQLANVPHLTEKSAQRK
PSKTKVKKEQSLARLYGAKKDKKGKYSEKDLNIPTLNRAIVPGVKIRRGKKGKKFIAD
NDTLTLNRLITTIGDKYDDIAESKLEKARRLEEIRELKRKEIERKEALKQDKLEEKKD
EIKKKSSVARTIRRKNKRDMLKSEAKASESKTEGRKVKKVSFAQ"
gene <150016..>152535
/gene="NIC96"
/locus_tag="YFR002W"
/db_xref="GeneID:850552"
mRNA <150016..>152535
/gene="NIC96"
/locus_tag="YFR002W"
/product="linker nucleoporin NIC96"
/transcript_id="NM_001179967.1"
/db_xref="GeneID:850552"
CDS 150016..152535
/gene="NIC96"
/locus_tag="YFR002W"
/experiment="EXISTENCE:direct assay:GO:0005643 nuclear
pore [PMID:10684247|PMID:7688296]"
/experiment="EXISTENCE:direct assay:GO:0044612 nuclear
pore linkers [PMID:18046406]"
/experiment="EXISTENCE:direct assay:GO:0044615 nuclear
pore nuclear basket [PMID:9813081]"
/experiment="EXISTENCE:mutant phenotype:GO:0000055
ribosomal large subunit export from nucleus
[PMID:11071906]"
/experiment="EXISTENCE:mutant phenotype:GO:0006606 protein
import into nucleus [PMID:12730220|PMID:7828598]"
/experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear
pore organization [PMID:11121302|PMID:8682854]"
/experiment="EXISTENCE:mutant phenotype:GO:0017056
structural constituent of nuclear pore [PMID:18206968]"
/note="Linker nucleoporin component of the nuclear pore
complex (NPC); also part of the NPC nuclear basket;
contributes to nucleocytoplasmic transport and NPC
biogenesis; forms stable associations with three
FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)"
/codon_start=1
/product="linker nucleoporin NIC96"
/protein_id="NP_116657.1"
/db_xref="GeneID:850552"
/db_xref="SGD:S000001898"
/translation="MLETLRGNKLHSGTSKGANKKLNELLESSDNLPSASSELGSIQV
SINELRRRVFQLRSKNKASKDYTKAHYLLANSGLSFEDVDAFIKDLQTNQFLEPNPPK
IIESEELEFYIRTKKEENILMSIEQLLNGATKDFDNFINHNLNLDWAQHKNEVMKNFG
ILIQDKKTVDHKKSISSLDPKLPSWGNKGNNILNSNESRLNVNENNILREKFENYARI
VFQFNNSRQANGNFDIANEFISILSSANGTRNAQLLESWKILESMKSKDINIVEVGKQ
YLEQQFLQYTDNLYKKNMNEGLATNVNKIKSFIDTKLKKADKSWKISNLTVINGVPIW
ALIFYLLRAGLIKEALQVLVENKANIKKVEQSFLTYFKAYASSKDHGLPVEYSTKLHT
EYNQHIKSSLDGDPYRLAVYKLIGRCDLSRKNIPAVTLSIEDWLWMHLMLIKEKDAEN
DPVYERYSLEDFQNIIISYGPSRFSNYYLQTLLLSGLYGLAIDYTYTFSEMDAVHLAI
GLASLKLFKIDSSTRLTKKPKRDIRFANILANYTKSFRYSDPRVAVEYLVLITLNEGP
TDVELCHEALRELVLETKEFTVLLGKIGRDGARIPGVIEERQPLLHVRDEKEFLHTIT
EQAARRADEDGRIYDSILLYQLAEEYDIVITLVNSLLSDTLSASDLDQPLVGPDDNSE
TNPVLLARRMASIYFDNAGISRQIHVKNKEICMLLLNISSIRELYFNKQWQETLSQME
LLDLLPFSDELSARKKAQDFSNLDDNIVKNIPNLLIITLSCISNMIHILNESKYQSST
KGQQIDSLKNVARQCMIYAGMIQYRMPRETYSTLINIDVSL"
gene complement(<152657..>153124)
/gene="YPI1"
/locus_tag="YFR003C"
/db_xref="GeneID:850553"
mRNA complement(<152657..>153124)
/gene="YPI1"
/locus_tag="YFR003C"
/product="type 1 protein phosphatase-activating protein
YPI1"
/transcript_id="NM_001179968.1"
/db_xref="GeneID:850553"
CDS complement(152657..153124)
/gene="YPI1"
/locus_tag="YFR003C"
/experiment="EXISTENCE:direct assay:GO:0004865 protein
serine/threonine phosphatase inhibitor activity
[PMID:14506263]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:17142459|PMID:18172024]"
/experiment="EXISTENCE:direct assay:GO:0035308 negative
regulation of protein dephosphorylation [PMID:14506263]"
/experiment="EXISTENCE:direct assay:GO:1900180 regulation
of protein localization to nucleus [PMID:18172024]"
/experiment="EXISTENCE:genetic interaction:GO:0007094
mitotic spindle assembly checkpoint signaling
[PMID:18172024]"
/experiment="EXISTENCE:genetic interaction:GO:0035307
positive regulation of protein dephosphorylation
[PMID:18172024]"
/experiment="EXISTENCE:genetic interaction:GO:0072542
protein phosphatase activator activity [PMID:18172024]"
/experiment="EXISTENCE:mutant phenotype:GO:0004865 protein
serine/threonine phosphatase inhibitor activity
[PMID:14506263]"
/experiment="EXISTENCE:mutant phenotype:GO:0005977
glycogen metabolic process [PMID:14506263]"
/experiment="EXISTENCE:mutant phenotype:GO:0006873
intracellular monoatomic ion homeostasis [PMID:22367039]"
/experiment="EXISTENCE:mutant phenotype:GO:0035308
negative regulation of protein dephosphorylation
[PMID:14506263]"
/experiment="EXISTENCE:mutant phenotype:GO:1900180
regulation of protein localization to nucleus
[PMID:17142459]"
/note="Regulatory subunit of the type I protein
phosphatase (PP1) Glc7p; Glc7p participates in the
regulation of a variety of metabolic processes including
mitosis and glycogen metabolism; in vitro evidence
suggests Ypi1p is an inhibitor of Glc7p while in vivo
evidence suggests it is an activator; overproduction
causes decreased cellular content of glycogen; partial
depletion causes lithium sensitivity, while overproduction
confers lithium-tolerance"
/codon_start=1
/product="type 1 protein phosphatase-activating protein
YPI1"
/protein_id="NP_116658.1"
/db_xref="GeneID:850553"
/db_xref="SGD:S000001899"
/translation="MSGNQMAMGSEQQQTVGSRTVSVEEVPAVLQLRATQDPPRSQEA
MPTRHNVRWEENVIDNENMNKKKTKICCIFHPQNEDEEECNHHSDDDGSSSSGSSSSE
SENEKDLDFNERRQRRLERRHRKLEKKRSYSPNAYEIQPDYSEYRRKQQEKKD"
gene <153393..>154313
/gene="RPN11"
/locus_tag="YFR004W"
/gene_synonym="MPR1"
/db_xref="GeneID:850554"
mRNA <153393..>154313
/gene="RPN11"
/locus_tag="YFR004W"
/gene_synonym="MPR1"
/product="proteasome regulatory particle lid subunit
RPN11"
/transcript_id="NM_001179969.1"
/db_xref="GeneID:850554"
CDS 153393..154313
/gene="RPN11"
/locus_tag="YFR004W"
/gene_synonym="MPR1"
/EC_number="3.4.19.12"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:15210724]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:19773362]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:19773362]"
/experiment="EXISTENCE:direct assay:GO:0008541 proteasome
regulatory particle, lid subcomplex
[PMID:11742986|PMID:9741626]"
/experiment="EXISTENCE:direct assay:GO:0016579 protein
deubiquitination [PMID:25389291]"
/experiment="EXISTENCE:direct assay:GO:0034515 proteasome
storage granule [PMID:18504300]"
/experiment="EXISTENCE:direct assay:GO:0140492
metal-dependent deubiquitinase activity [PMID:25389291]"
/experiment="EXISTENCE:genetic interaction:GO:0016579
protein deubiquitination [PMID:14581483]"
/experiment="EXISTENCE:genetic interaction:GO:0043248
proteasome assembly [PMID:20941496]"
/experiment="EXISTENCE:mutant phenotype:GO:0000266
mitochondrial fission [PMID:19773362]"
/experiment="EXISTENCE:mutant phenotype:GO:0016559
peroxisome fission [PMID:19773362]"
/experiment="EXISTENCE:mutant phenotype:GO:0016579 protein
deubiquitination [PMID:12183636]"
/experiment="EXISTENCE:mutant phenotype:GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic
process [PMID:12183636]"
/experiment="EXISTENCE:mutant phenotype:GO:0043248
proteasome assembly [PMID:20061387]"
/experiment="EXISTENCE:mutant phenotype:GO:0140492
metal-dependent deubiquitinase activity
[PMID:12353037|PMID:12183636]"
/experiment="EXISTENCE:mutant phenotype:GO:1902906
proteasome storage granule assembly [PMID:23936414]"
/note="Metalloprotease subunit of 19S regulatory particle;
part of 26S proteasome lid; couples the deubiquitination
and degradation of proteasome substrates; involved,
independent of catalytic activity, in fission of
mitochondria and peroxisomes; protein abundance increases
in response to DNA replication stress"
/codon_start=1
/product="proteasome regulatory particle lid subunit
RPN11"
/protein_id="NP_116659.1"
/db_xref="GeneID:850554"
/db_xref="SGD:S000001900"
/translation="MERLQRLMMNSKVGSADTGRDDTKETVYISSIALLKMLKHGRAG
VPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGTGVSVEAVDDVFQAKMMDMLKQTGRDQ
MVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLID
TGALINNLEPRQTTSNTGLLNKANIQALIHGLNRHYYSLNIDYHKTAKETKMLMNLHK
EQWQSGLKMYDYEEKEESNLAATKSMVKIAEQYSKRIEEEKELTEEELKTRYVGRQDP
KKHLSETADETLENNIVSVLTAGVNSVAIK"
gene complement(<154527..>155873)
/gene="SAD1"
/locus_tag="YFR005C"
/db_xref="GeneID:850555"
mRNA complement(<154527..>155873)
/gene="SAD1"
/locus_tag="YFR005C"
/product="mRNA splicing protein SAD1"
/transcript_id="NM_001179970.1"
/db_xref="GeneID:850555"
CDS complement(154527..155873)
/gene="SAD1"
/locus_tag="YFR005C"
/experiment="EXISTENCE:direct assay:GO:0000245
spliceosomal complex assembly [PMID:24681967]"
/experiment="EXISTENCE:direct assay:GO:0000398 mRNA
splicing, via spliceosome [PMID:10022888]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:10022888]"
/note="Conserved zinc-finger domain protein involved in
pre-mRNA splicing; critical for splicing of nearly all
intron-containing genes; required for assembly of U4 snRNA
into the U4/U6 particle"
/codon_start=1
/product="mRNA splicing protein SAD1"
/protein_id="NP_116660.1"
/db_xref="GeneID:850555"
/db_xref="SGD:S000001901"
/translation="MEVDNKRRHSEDELKQEAVKKIKSQEPNYAYLETVVREKLDFDS
EKICCITLSPLNVYCCLVCGHYYQGRHEKSPAFIHSIDENHHVFLNLTSLKFYMLPQN
VQILHDGEVQLLNSIKFAAYPTYCPKDLEDFPRQCFDLSNRTYLNGFIGFTNAATYDY
AHSVLLLISHMVPVRDHFLLNHFDNQGEFIKRLSICVKKIWSPKLFKHHLSVDDFVSY
LKVREGLNLNPIDPRLFLLWLFNKICSSSNDLKSILNHSCKGKVKIAKVENKPEASES
VTGKVIVKPFWVLTLDLPEFSPFEDGNSVDDLPQINITKLLTKFTKSRSSSTSTVFEL
TRLPQFLIFHFNRFDRNSDHPVKNRNQTLVEFSSELEILHVKYRLKANVVHVVIKQPS
TDGNAFNGDEKSHWITQLYDNKSEKWIEIDGINTTEREAELLFLKETFIQVWEKQE"
gene <156145..>157752
/locus_tag="YFR006W"
/db_xref="GeneID:850556"
mRNA <156145..>157752
/locus_tag="YFR006W"
/product="putative Xaa-Pro dipeptidase"
/transcript_id="NM_001179971.1"
/db_xref="GeneID:850556"
CDS 156145..157752
/locus_tag="YFR006W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/note="Putative X-Pro aminopeptidase; green fluorescent
protein (GFP)-fusion protein localizes to the cytoplasm;
YFR006W is not an essential gene"
/codon_start=1
/product="putative Xaa-Pro dipeptidase"
/protein_id="NP_116661.1"
/db_xref="GeneID:850556"
/db_xref="SGD:S000001902"
/translation="MCLEPISLVVFGSLVFFFGLVKYFKRGERQRTRGILQPEYKDKY
YYSKEKGEEMGEVANVNEIPVKIRNHKYPAKEHNLRVKDLLLNRNPKLSKISTAFFIA
GEELEGNKYCDTNKDFRQNRYFYHLSGVDIPASAILFNCSTDKLTLFLPNIDEEDVIW
SGMPLSLDEAMRVFDIDEALYISDLGKKFKELQDFAIFTTDLDNVHDENIARSLIPSD
PNFFYAMDETRAIKDWYEIESIRKACQISDKSHLAVMSALPIELNELQIQAEFEYHAT
RQGGRSLGYDPICCSGPACGTLHYVKNSEDIKGKHSILIDAGAEWRQYTSDITRCFPT
SGKFTAEHREVYETVLDMQNQAMERIKPGAKWDDLHALTHKVLIKHFLSMGIFKKEFS
EDEIFKRRASCAFYPHGLGHMLGLDVHDVGGNPNYDDPDPMFRYLRIRRPLKENMVIT
NEPGCYFNQFLIKEFLEKHPERLEVVDMSVLKRYMYVGGVRIEDDILVTKDGYENLTG
ITSDPDEIEKIVQKGLKKPRSGFHVIV"
gene complement(157916..158007)
/locus_tag="YNCF0005C"
/db_xref="GeneID:850557"
tRNA complement(join(157916..157951,157971..158007))
/locus_tag="YNCF0005C"
/product="tRNA-Phe"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Phenylalanine tRNA (tRNA-Phe), predicted by
tRNAscan-SE analysis"
/db_xref="GeneID:850557"
/db_xref="SGD:S000006564"
repeat_region 158376..158686
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006933"
gene <159299..>160360
/gene="YFH7"
/locus_tag="YFR007W"
/gene_synonym="AIM12"
/db_xref="GeneID:850558"
mRNA <159299..>160360
/gene="YFH7"
/locus_tag="YFR007W"
/gene_synonym="AIM12"
/product="Yfh7p"
/transcript_id="NM_001179972.1"
/db_xref="GeneID:850558"
CDS 159299..160360
/gene="YFH7"
/locus_tag="YFR007W"
/gene_synonym="AIM12"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:18004758]"
/note="Putative kinase with similarity to the PRK/URK/PANK
kinase subfamily; the PRK/URK/PANK subfamily of P-loop
kinases is also known as phosphoribulokinase/uridine
kinase/bacterial pantothenate kinase"
/codon_start=1
/product="Yfh7p"
/protein_id="NP_116662.1"
/db_xref="GeneID:850558"
/db_xref="SGD:S000001903"
/translation="MVDTHKLADDVLQLLDNRIEDNYRVCVILVGSPGSGKSTIAEEL
CQIINEKYHTFLSEHPNVIEVNDRLKPMVNLVDSLKTLQPNKVAEMIENQGLFKDHVE
DVNFQPVKYSALTSNNEECTAVVARGGTANAIRIAAVDNPVNVNKLAQDSINIAQIVP
MDGFHLSRRCLDLFKDPQTAHKRRGSPSTFDSNNFLQLCKILAKTSLCKVSSHHKFYS
TSSVFEKLSKTFSQTIPDIFVPGFNHALKDPTPDQYCISKFTRIVILEGLYLLYDQEN
WKKIYKTLADTGALLVYKIDIDYEATEERVAKRHLQSGLVTTIAEGREKFRSNDLLNG
RDIDNHLIKVDNIVHIRND"
gene <160535..>161200
/gene="FAR7"
/locus_tag="YFR008W"
/db_xref="GeneID:850559"
mRNA <160535..>161200
/gene="FAR7"
/locus_tag="YFR008W"
/product="Far7p"
/transcript_id="NM_001179973.1"
/db_xref="GeneID:850559"
CDS 160535..161200
/gene="FAR7"
/locus_tag="YFR008W"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:23625923]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0000321
re-entry into mitotic cell cycle after pheromone arrest
[PMID:12588993]"
/note="Protein involved in recovery from pheromone-induced
cell cycle arrest; acts in a Far1p-independent pathway;
interacts with Far3p, Far8p, Far9p, Far10p, and Far11p;
protein abundance increases in response to DNA replication
stress"
/codon_start=1
/product="Far7p"
/protein_id="NP_116663.1"
/db_xref="GeneID:850559"
/db_xref="SGD:S000001904"
/translation="MSDQINVLSMQQQQQQQQQQQQVYMSPQAENLNHMYLLVNKLVK
QLRENQAEKAKILRNIDILSGSLNKYETSEEPHDTTENIALFNRFLEQRGKAPITEKE
QLSNNLDENAKDDVMLGVLKRQNSMLRKSLQESKQVTLESMDLLSYSEDSLNYIVAQL
RGNILMHHKETIKLIRQKFQTETIPLEDEEFKMYLENVNGLQKLTDISHTYRLLLRLH
AQD"
repeat_region complement(161804..162135)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006931"
gene 162228..162298
/gene="SUF20"
/locus_tag="YNCF0006W"
/db_xref="GeneID:850560"
tRNA 162228..162298
/gene="SUF20"
/locus_tag="YNCF0006W"
/product="tRNA-Gly"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0030371 translation
repressor activity [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043022 ribosome
binding [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043555 regulation
of translation in response to stress [PMID:27609601]"
/note="Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE
analysis; can mutate to suppress +1 frameshift mutations
in glycine codons"
/db_xref="GeneID:850560"
/db_xref="SGD:S000006579"
gene <162488..>164746
/gene="GCN20"
/locus_tag="YFR009W"
/db_xref="GeneID:850561"
mRNA <162488..>164746
/gene="GCN20"
/locus_tag="YFR009W"
/product="putative AAA family ATPase GCN20"
/transcript_id="NM_001179974.1"
/db_xref="GeneID:850561"
CDS 162488..164746
/gene="GCN20"
/locus_tag="YFR009W"
/experiment="EXISTENCE:direct assay:GO:0022626 cytosolic
ribosome [PMID:9234705]"
/experiment="EXISTENCE:mutant phenotype:GO:0006448
regulation of translational elongation [PMID:9234705]"
/experiment="EXISTENCE:mutant phenotype:GO:0043335 protein
unfolding [PMID:32320318]"
/note="Positive regulator of the Gcn2p kinase activity;
important for disaggregation of ordered and disordered
protein aggregates; forms a complex with Gcn1p; proposed
to stimulate Gcn2p activation by an uncharged tRNA;
suppresses frameshifting at stalled ribosomes"
/codon_start=1
/product="putative AAA family ATPase GCN20"
/protein_id="NP_116664.1"
/db_xref="GeneID:850561"
/db_xref="SGD:S000001905"
/translation="MASIGSQVRKAASSIDPIVTDYAVGYFNHLSGITFDAVQSKQVD
LSTEVQFVSDLLIDAGASKAKVKELSESILKQLTTQLKENEAKLELTGDTSKRLLDIN
VLKSHNSKSDINVSLSMLGVNGDIEHTGRKMETRVDLKKLAKAEQKIAKKVAKRNNKF
VKYEASKLINDQKEEDYDSFFLQINPLEFGSSAGKSKDIHIDTFDLYVGDGQRILSNA
QLTLSFGHRYGLVGQNGIGKSTLLRALSRRELNVPKHVSILHVEQELRGDDTKALQSV
LDADVWRKQLLSEEAKINERLKEMDVLRQEFEEDSLEVKKLDNEREDLDNHLIQISDK
LVDMESDKAEARAASILYGLGFSTEAQQQPTNSFSGGWRMRLSLARALFCQPDLLLLD
EPSNMLDVPSIAYLAEYLKTYPNTVLTVSHDRAFLNEVATDIIYQHNERLDYYRGQDF
DTFYTTKEERRKNAQREYDNQMVYRKHLQEFIDKYRYNAAKSQEAQSRIKKLEKLPVL
EPPEQDKTIDFKFPECDKLSPPIIQLQDVSFGYDENNLLLKDVNLDVQMDSRIALVGA
NGCGKTTLLKIMMEQLRPLKGFVSRNPRLRIGYFTQHHVDSMDLTTSAVDWMSKSFPG
KTDEEYRRHLGSFGITGTLGLQKMQLLSGGQKSRVAFAALCLNNPHILVLDEPSNHLD
TTGLDALVEALKNFNGGVLMVSHDISVIDSVCKEIWVSEQGTVKRFEGTIYDYRDYIL
QSADAAGVVKKH"
gene <165067..>166566
/gene="UBP6"
/locus_tag="YFR010W"
/db_xref="GeneID:850562"
mRNA <165067..>166566
/gene="UBP6"
/locus_tag="YFR010W"
/product="ubiquitin-specific protease UBP6"
/transcript_id="NM_001179975.1"
/db_xref="GeneID:850562"
CDS 165067..166566
/gene="UBP6"
/locus_tag="YFR010W"
/EC_number="3.4.19.12"
/experiment="EXISTENCE:direct assay:GO:0000502 proteasome
complex [PMID:12408819]"
/experiment="EXISTENCE:direct assay:GO:0004843
cysteine-type deubiquitinase activity
[PMID:12408819|PMID:17018280]"
/experiment="EXISTENCE:direct assay:GO:0005838 proteasome
regulatory particle [PMID:11029046]"
/experiment="EXISTENCE:genetic interaction:GO:0016579
protein deubiquitination [PMID:14581483]"
/experiment="EXISTENCE:mutant phenotype:GO:0004843
cysteine-type deubiquitinase activity
[PMID:12408819|PMID:17018280]"
/experiment="EXISTENCE:mutant phenotype:GO:0016579 protein
deubiquitination [PMID:12408819]"
/experiment="EXISTENCE:mutant phenotype:GO:0072671
mitochondria-associated ubiquitin-dependent protein
catabolic process [PMID:21070972]"
/experiment="EXISTENCE:mutant phenotype:GO:1901799
negative regulation of proteasomal protein catabolic
process [PMID:17018280]"
/note="Ubiquitin-specific protease; situated in the base
subcomplex of the 26S proteasome, releases free ubiquitin
from branched polyubiquitin chains en bloc, rather than
from the distal tip of the chain; negatively regulates
degradation of ubiquitinated proteins by the proteasome;
works in opposition to Hul5p polyubiquitin elongation
activity; mutant has aneuploidy tolerance; human homolog
UBP14 complements yeast null mutant"
/codon_start=1
/product="ubiquitin-specific protease UBP6"
/protein_id="NP_116665.1"
/db_xref="GeneID:850562"
/db_xref="SGD:S000001906"
/translation="MSGETFEFNIRHSGKVYPITLSTDATSADLKSKAEELTQVPSAR
QKYMVKGGLSGEESIKIYPLIKPGSTVMLLGTPDANLISKPAKKNNFIEDLAPEQQVQ
QFAQLPVGFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQI
VIEMKRCFENLQNKSFKSVLPIVLLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLF
HSMSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQCHISGTTNFMRNGL
LEGLNEKIEKRSDLTGANSIYSVEKKISRLPKFLTVQYVRFFWKRSTNKKSKILRKVV
FPFQLDVADMLTPEYAAEKVKVRDELRKVEKEKNEKEREIKRRKFDPSSSENVMTPRE
QYETQVALNESEKDQWLEEYKKHFPPNLEKGENPSCVYNLIGVITHQGANSESGHYQA
FIRDELDENKWYKFNDDKVSVVEKEKIESLAGGGESDSALILMYKGFGL"
gene complement(<166746..>167258)
/gene="MIC19"
/locus_tag="YFR011C"
/gene_synonym="AIM13; MCS19"
/db_xref="GeneID:850563"
mRNA complement(<166746..>167258)
/gene="MIC19"
/locus_tag="YFR011C"
/gene_synonym="AIM13; MCS19"
/product="Mic19p"
/transcript_id="NM_001179976.1"
/db_xref="GeneID:850563"
CDS complement(166746..167258)
/gene="MIC19"
/locus_tag="YFR011C"
/gene_synonym="AIM13; MCS19"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0044284
mitochondrial crista junction [PMID:22009199]"
/experiment="EXISTENCE:direct assay:GO:0061617 MICOS
complex [PMID:21944719|PMID:21987634|PMID:22009199]"
/experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae
formation [PMID:21944719|PMID:21987634|PMID:22009199]"
/note="Component of the MICOS complex; MICOS (formerly
MINOS or MitOS) is a mitochondrial inner membrane complex
that extends into the intermembrane space and has a role
in the maintenance of crista junctions, inner membrane
architecture, and formation of contact sites to the outer
membrane; Mic19p is peripheral to the inner membrane and
may connect Mic60p with the Mic10p-Mic12p-Mic27p
subcomplex; both yeast and human Mic19p become oxidized,
and oxidation may regulate MICOS"
/codon_start=1
/product="Mic19p"
/protein_id="NP_116666.1"
/db_xref="GeneID:850563"
/db_xref="SGD:S000001907"
/translation="MGSNTSKVGAGAEKQQVYTPLTQIDFSQSLVSQLDSSKESDYVT
KQNAEKFIEKKVSQRLSNLEVETLKKFEDTLNNSLLSDDDKDAVDGISSSSLNNQIES
LNKKLTLFDQLELQKLEKYGGAKGKSDKKTDNGSISIKAKLTECLLANKGKPLNCYEE
MEEFKKLVMG"
gene 167437..167525
/gene="SUP11"
/locus_tag="YNCF0007W"
/db_xref="GeneID:850564"
tRNA join(167437..167475,167490..167525)
/gene="SUP11"
/locus_tag="YNCF0007W"
/product="tRNA-Tyr"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE
analysis; can mutate to suppress ochre nonsense mutations"
/db_xref="GeneID:850564"
/db_xref="SGD:S000006779"
rep_origin 167547..167801
/note="ARS606; Highly-efficient autonomously replicating
sequence on Chromosome VI; activated early in S phase in
74% of cell cycles; replication capacity dependent upon
Sum1p"
/db_xref="SGD:S000007638"
gene <167888..>168496
/gene="DCV1"
/locus_tag="YFR012W"
/db_xref="GeneID:850565"
mRNA <167888..>168496
/gene="DCV1"
/locus_tag="YFR012W"
/product="Dcv1p"
/transcript_id="NM_001179977.1"
/db_xref="GeneID:850565"
CDS 167888..168496
/gene="DCV1"
/locus_tag="YFR012W"
/experiment="EXISTENCE:direct assay:GO:0005635 nuclear
envelope [PMID:33002606]"
/note="hypothetical protein; deletion mutant shows strong
genetic interaction with cdc28-as1 mutant in the presence
of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from
the whole genome duplication"
/codon_start=1
/product="Dcv1p"
/protein_id="NP_116667.1"
/db_xref="GeneID:850565"
/db_xref="SGD:S000001908"
/translation="MLNYKLILLFSSFLQLISFSGFMICCLTSPIIRNWGLAQAAGVS
YGTFGYCKTLNSFSCSRVRLIYNTSKEILPGPSLERWWLSPKARHTIGGLLISIPVAT
CLTFISFALPLVIIFLFQTGGTNVSLITSNAILHILTLLSTIFACTVILLLCMHRDPV
TISSLYDLVWLANCSLFPLLVIGVHFLSFRFDTSAQSDRKHS"
gene <169224..>169310
/locus_tag="YFR012W-A"
/db_xref="GeneID:850566"
mRNA <169224..>169310
/locus_tag="YFR012W-A"
/product="uncharacterized protein"
/transcript_id="NM_001184472.1"
/db_xref="GeneID:850566"
CDS 169224..169310
/locus_tag="YFR012W-A"
/note="hypothetical protein; identified by homology"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_076889.1"
/db_xref="GeneID:850566"
/db_xref="SGD:S000007606"
/translation="MLPRKYKPAYKKQAHRVKSNPQPAYTFQ"
gene <169922..>172285
/gene="IOC3"
/locus_tag="YFR013W"
/db_xref="GeneID:850567"
mRNA <169922..>172285
/gene="IOC3"
/locus_tag="YFR013W"
/product="Ioc3p"
/transcript_id="NM_001179978.1"
/db_xref="GeneID:850567"
CDS 169922..172285
/gene="IOC3"
/locus_tag="YFR013W"
/experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
[PMID:12482963]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:12482963]"
/experiment="EXISTENCE:direct assay:GO:0031491 nucleosome
binding [PMID:12482963]"
/experiment="EXISTENCE:direct assay:GO:0036436 Isw1a
complex [PMID:12482963]"
/experiment="EXISTENCE:mutant phenotype:GO:0007062 sister
chromatid cohesion [PMID:27185881]"
/note="Subunit of the Isw1a complex; Isw1a has
nucleosome-stimulated ATPase activity and represses
transcription initiation by specific positioning of a
promoter proximal dinucleosome; promotes nucleosome shifts
in the 5 prime direction; IOC3 has a paralog, ESC8, that
arose from the whole genome duplication"
/codon_start=1
/product="Ioc3p"
/protein_id="NP_116668.1"
/db_xref="GeneID:850567"
/db_xref="SGD:S000001909"
/translation="MDSPSNSIQNLQQEAQGSSSAQLADHDHDRVSMAMPLQTDQSVS
VSQSSDNLRRSRRVPKPRTSIYDEYEEELKERANKPKRKRPAPPKKKAPSTQNSKSND
KVEKKKTTSIAKDGKPTLKTNDKKVAPKPKPAHEQVEPALIPSNWTSVIPLLTSDFKN
QYSVISRLKNPNMKPVPYAGDIIKLMAFINKFSSFFHSDLQNLSFQDFEVGLDLYPGD
PNGSAAGIVKGPEDTSLLLYPDFMAIKDIVYCQDKMNLLFLSLLDLTFTENFDGKSAK
KKGPLTTWENLKSSSKKVFSNPLYRLRLVAREWGYPREWRQQLPSDQDISKPKTALFE
QDEQTPVVDPSHPEILTPNIYTWNANEPLPLESNPLYNREMDKNGILALKPMDRVVLL
RALTDWCASHSSAIHDEIYKLTHGKKDPVFGIQTQQVPRYTIEGVDNTINQFKKLCSL
IQSRYEIRSKKKHFVKQLKEGKKPDLSRKLEILKEIKAELKNAVKSEKDELLFSLYDK
WVPLFEGELPDQPLANPFSERLYKLRLQEFFLGRVPHIGDFYMPRLHSYGDSLEMSTF
TDLRNLQALLSKFKNNEYNAFTLFENDGQSMSAQFKLFYHDTPSLAHDVARGRNTSGK
VYWYELCHDSATLLEFLEFLDYKIVKPQDEKKEGNEKEKEALNNEAHILEQKSTTDNN
PSINTNPLPKDAKYNTARKKLQILKEFLSDYYFILRQFEQMKVQFADMKPGKRQLRRI
QRQTVNYNTEYDSEEYVDDEEDDEADIYDDNDNDSSFDDGRVKRQRT"
gene complement(<172537..>173877)
/gene="CMK1"
/locus_tag="YFR014C"
/db_xref="GeneID:850568"
mRNA complement(<172537..>173877)
/gene="CMK1"
/locus_tag="YFR014C"
/product="calmodulin-dependent protein kinase CMK1"
/transcript_id="NM_001179979.2"
/db_xref="GeneID:850568"
CDS complement(172537..173877)
/gene="CMK1"
/locus_tag="YFR014C"
/EC_number="2.7.11.17"
/experiment="EXISTENCE:direct assay:GO:0004672 protein
kinase activity [PMID:16319894]"
/experiment="EXISTENCE:direct assay:GO:0004683
calmodulin-dependent protein kinase activity
[PMID:2061341]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:9756868]"
/experiment="EXISTENCE:mutant phenotype:GO:0007165 signal
transduction [PMID:11743609]"
/note="Calmodulin-dependent protein kinase; may play a
role in stress response, many Ca++/calmodulin dependent
phosphorylation substrates demonstrated in vitro, amino
acid sequence similar to mammalian Cam Kinase II; CMK1 has
a paralog, CMK2, that arose from the whole genome
duplication"
/codon_start=1
/product="calmodulin-dependent protein kinase CMK1"
/protein_id="NP_116669.1"
/db_xref="GeneID:850568"
/db_xref="SGD:S000001910"
/translation="MDDKVSEKESSPKQTEEDSEGKMAHVQPASYVNKKKYVFGKTLG
AGTFGVVRQAKNTETGEDVAVKILIKKALKGNKVQLEALYDELDILQRLHHPNIVAFK
DWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHR
DLKPENLLYIDKSDESPLVVADFGIAKRLKSDEELLYKPAGSLGYVAPEVLTQDGHGK
PCDIWSIGVITYTLLCGYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFI
LKALNLDPSKRPTAAELLEDPWIICTELKTHNLLPGLKEGLDARQKFRNSVERVRLNM
KIQKLRDLYLEQTESDSDFDEGSQANGSVPPLKATDTSQLSKKLSEEEQSKLKSELTS
KAFAQLVNTVLAEKEKFLNINRVCSSDSDLPGSDIKSLDEAKEKPEGKDTKTEE"
gene complement(<174265..>176391)
/gene="GSY1"
/locus_tag="YFR015C"
/db_xref="GeneID:850569"
mRNA complement(<174265..>176391)
/gene="GSY1"
/locus_tag="YFR015C"
/product="glycogen (starch) synthase GSY1"
/transcript_id="NM_001179980.1"
/db_xref="GeneID:850569"
CDS complement(174265..176391)
/gene="GSY1"
/locus_tag="YFR015C"
/EC_number="2.4.1.11"
/experiment="EXISTENCE:direct assay:GO:0004373 glycogen
(starch) synthase activity [PMID:2123485]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095|PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:mutant phenotype:GO:0005978
glycogen biosynthetic process [PMID:1908457]"
/note="Glycogen synthase; expression induced by glucose
limitation, nitrogen starvation, environmental stress, and
entry into stationary phase; GSY1 has a paralog, GSY2,
that arose from the whole genome duplication; relocalizes
from nucleus to cytoplasmic foci upon DNA replication
stress"
/codon_start=1
/product="glycogen (starch) synthase GSY1"
/protein_id="NP_116670.1"
/db_xref="GeneID:850569"
/db_xref="SGD:S000001911"
/translation="MARDLQNHLLFEVATEVTNRVGGIYSVLKSKAPVTVAQYGDNYT
LLGPLNKATYESEVEKLDWEDESIFPEELLPIQKTLMSMREKGVNFVYGNWLIEGAPR
VILFELDSVRHFLNEWKADLWSLVGIPSPEHDHETNDAILLGYVVVWFLGEVSKLDSS
HAIIGHFHEWLAGVALPLCRKKRIDVVTIFTTHATLLGRYLCAAGDVDFYNNLQYFDV
DQEAGKRGIYHRYCIERAAAHTADVFTTVSQITALEAEHLLKRKPDGILPNGLNVVKF
QAVHEFQNLHALKKDKINDFVRGHFHGCFDFDLDNTVYFFIAGRYEYKNKGADMFIES
LARLNYRLKVSGSKKTVVAFLIMPAKTNSFTVEALKSQAIVKSLENTVNEVTASIGKR
IFEHTMRYPHNGLESELPTNLDELLKSSEKVLLKKRVLALRRPYGELPPVVTHNMCDD
ANDPILNQIRHVRLFNDSSDRVKVIFHPEFLNANNPILGLDYDEFVRGCHLGVFPSYY
EPWGYTPAECTVMGVPSITTNVSGFGAYMEDLIETDQAKDYGIYIVDRRFKSPDESVE
QLADYMEEFVNKTRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLGLRRAYPEQFKQ
LVGETISDANMNTLAGGKKFKIARPLSVPGSPKVRSNSTVYMTPGDLGTLQDANNADD
YFNLSTNGAIDNDDDDNDTSAYYEDN"
gene complement(<177042..>180743)
/gene="AIP5"
/locus_tag="YFR016C"
/db_xref="GeneID:850570"
mRNA complement(<177042..>180743)
/gene="AIP5"
/locus_tag="YFR016C"
/product="Aip5p"
/transcript_id="NM_001179981.1"
/db_xref="GeneID:850570"
CDS complement(177042..180743)
/gene="AIP5"
/locus_tag="YFR016C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005933 cellular
bud [PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005934 cellular
bud tip [PMID:31699995]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:31699995]"
/experiment="EXISTENCE:direct assay:GO:0032233 positive
regulation of actin filament bundle assembly
[PMID:31699995]"
/note="Protein that positively regulates actin assembly;
forms a homodimer and interacts with G-actin; localization
to the bud neck and bud tip requires Spa2p; YFR016C is not
an essential gene"
/codon_start=1
/product="Aip5p"
/protein_id="NP_116671.1"
/db_xref="GeneID:850570"
/db_xref="SGD:S000001912"
/translation="MVESLTVENQEHNVQPPSVTSAGDSYSTLATDLPLPSTNDIIES
RDQLTESDLDEAINATENFAQELSSQRKSSKLKGHKKKNQGQIKANRDRDTIVKLSSS
VGETEEASTRDAISHDLERKDDVIEIATDTINDATESPTQIPIDVNVVIKETSTNNVA
EGTENVPPIKESTGIEVGNSPITRRKKNKKKKTTNRRGRNSSNPADTTDLSKQSTLDS
ILVGIEEYLQEDGSKNEDIKVNIVQDEPVNVEKMDIRTRNESSDKTFDIDVPNKDNVD
ETSSKSENNINEEKAEHTLPREENEILNVNEGNAASFKHQLEPHGLEAGDENGQASTK
DVESESLTKNGFNFKENESKHLKAGEKQQTESDRDGISPSVLAKNQKETEIGKEDHVF
EQKDKEDEKCRKELSVNHENNMSHNFNAAGSDSIIPPETERETYDDETMGPTKRISDN
EKNLQHGTNDISVEVEKEEEEEEEEEENSTFSKVKKENVTGEQEAVRNNEVSGTEEES
TSKGEEIMGGDEKQSEAGEKSSIIEIEGSANSAKISKDNLVLEDEAEAPTQENKPTEV
VGEIDIPDAPRDDVEIVEAVEKNIIPEDLEVAKEDQEGEQVKLDEPVKAMKDDKIAMR
GAESISEDMKKKQEGTAELSNEKAKKEVDETARESAEGVEVEKSKTPESPKVVKRCTS
GRPEDLQINERDPEVLKEDVRVPDEDVKPEIATTIENSEEEDPKSQRVQISTEQAETT
QKDMGDVGSTTSFKEEEKPKRFEITQEGDKITGKDTNHEHGEATEAASENSKASDVGT
AEKYIEPSSESVKKDTEEDAEVENSEKTEFIKVKAELENLDAPKEAEVTAELNKENED
VEVDTEEDAEVENSEKTEFIKVKAELGNLDAPKEAEVTAELNKENEDVEVAATSKEDI
ETKCSEPAETPIEDGTCTEAEVSKKDAEAVTKEDENMENSKIAEALKDVTGDQEIDDI
NISDEFQRTVELPELEKQDIKDNKGEDKELEVEETEKETSLPDLVVEENITEEKNEIK
QEEEEVSQLDFNETESISKEAPNNDENGFEDQSTRENPKKASADDIFKDILDETNEFL
EQLKIVDDSELNALLQSLDAKDSTTQTTEQSKKNNDKPQDVITTSEIRKLNEKEPVYI
YTSLAGGGFHMIPRTNRLSTILTANRIPFTYRDLGTDDEARKVWKTFSKGRSLPGVVR
GHNDLIGNWEEIEEANEDYKLRELIYDTI"
gene complement(180974..181044)
/locus_tag="YNCF0008C"
/db_xref="GeneID:850571"
tRNA complement(180974..181044)
/locus_tag="YNCF0008C"
/product="tRNA-Gly"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0030371 translation
repressor activity [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043022 ribosome
binding [PMID:27609601]"
/experiment="EXISTENCE:direct assay:GO:0043555 regulation
of translation in response to stress [PMID:27609601]"
/note="Glycine tRNA (tRNA-Gly), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:850571"
/db_xref="SGD:S000006580"
gene complement(<182274..>182861)
/gene="IGD1"
/locus_tag="YFR017C"
/db_xref="GeneID:850572"
mRNA complement(<182274..>182861)
/gene="IGD1"
/locus_tag="YFR017C"
/product="Igd1p"
/transcript_id="NM_001179982.1"
/db_xref="GeneID:850572"
CDS complement(182274..182861)
/gene="IGD1"
/locus_tag="YFR017C"
/experiment="EXISTENCE:direct assay:GO:0004857 enzyme
inhibitor activity [PMID:21585652]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0004857 enzyme
inhibitor activity [PMID:21585652]"
/experiment="EXISTENCE:mutant phenotype:GO:0045818
negative regulation of glycogen catabolic process
[PMID:21585652]"
/note="Cytoplasmic protein that inhibits Gdb1p glycogen
debranching activity; required for normal intracellular
accumulation of glycogen; phosphorylated in vivo;
expression increases during wine fermentation; protein
abundance increases in response to DNA replication stress;
IGD1 has a paralog, YOL024W, that arose from the whole
genome duplication"
/codon_start=1
/product="Igd1p"
/protein_id="NP_116672.1"
/db_xref="GeneID:850572"
/db_xref="SGD:S000001913"
/translation="MTDPHLNTPQVSTSPTFERSQDFLNIDEPPCAQETPSVSTFNLP
GPSAPAQSVDKPVPMIRRRSTNYMDALNSREQARERESSIGEHAPGAERRSSGPMDFQ
NTIHNMQYRTTNDSDLSHAGVDMGDSISHTPICSRAGNRPIFKNSYLDNNSNGNSARV
PHGSPPQLGTRRKSSFKYEDFKKDIYNQLHMFGEK"
gene complement(<183131..>184222)
/locus_tag="YFR018C"
/db_xref="GeneID:850573"
mRNA complement(<183131..>184222)
/locus_tag="YFR018C"
/product="uncharacterized protein"
/transcript_id="NM_001179983.1"
/db_xref="GeneID:850573"
CDS complement(183131..184222)
/locus_tag="YFR018C"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/note="hypothetical protein; SWAT-GFP and seamless GFP
fusion proteins localize to the endoplasmic reticulum and
mCherry fusion protein localizes to the vacuole"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116673.1"
/db_xref="GeneID:850573"
/db_xref="SGD:S000001914"
/translation="MGMKYVLPLRLIGLAYLLVLFQVHRVTGWELSYEQYHAAHLNEA
INPDSGWNKSTKNLLLPFNRTRVPGSEGSREIQRFIIEHFNNTLAGEWAVETQAFEEN
GYRFNNLVMTLQNNASEYLVLAAHYDTKIAPTGMVGAIDSAASCAALLYTAQFLTHIA
CHERTKEYNDLESNTVVSNSTLGVKIVFFDGEEAIEEWGPEDSIYGARRLAAQWLADG
TMTRIRLLFLLDLLGSGEEEPLVPSYYAETHQEYQLLNRIEDDLLFRRGDEINGESAL
AAEVARQRKHLDPTDYRFLGLGHSVIGDDHTPFLAAGVPVLHAIPLPFPSTWHTVDDD
FRHLDAAETRHWALLVCEFVVQSLRSRNQ"
gene <184502..>191338
/gene="FAB1"
/locus_tag="YFR019W"
/gene_synonym="SVL7"
/db_xref="GeneID:850574"
mRNA <184502..>191338
/gene="FAB1"
/locus_tag="YFR019W"
/gene_synonym="SVL7"
/product="1-phosphatidylinositol-3-phosphate 5-kinase"
/transcript_id="NM_001179984.2"
/db_xref="GeneID:850574"
CDS 184502..191338
/gene="FAB1"
/locus_tag="YFR019W"
/gene_synonym="SVL7"
/EC_number="2.7.1.150"
/experiment="EXISTENCE:direct assay:GO:0000285
1-phosphatidylinositol-3-phosphate 5-kinase activity
[PMID:9811604]"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane [PMID:11889142|PMID:9763421]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0010008 endosome
membrane [PMID:11889142|PMID:9763421]"
/experiment="EXISTENCE:direct assay:GO:0032266
phosphatidylinositol-3-phosphate binding [PMID:9702203]"
/experiment="EXISTENCE:direct assay:GO:0046854
phosphatidylinositol phosphate biosynthetic process
[PMID:9811604]"
/experiment="EXISTENCE:direct assay:GO:0070772 PAS complex
[PMID:19037259]"
/experiment="EXISTENCE:mutant phenotype:GO:0000285
1-phosphatidylinositol-3-phosphate 5-kinase activity
[PMID:9763421|PMID:9811604]"
/experiment="EXISTENCE:mutant phenotype:GO:0046854
phosphatidylinositol phosphate biosynthetic process
[PMID:9763421|PMID:9811604]"
/experiment="EXISTENCE:physical interaction:GO:0070772 PAS
complex [PMID:19037259]"
/note="1-phosphatidylinositol-3-phosphate 5-kinase;
vacuolar membrane kinase that generates
phosphatidylinositol (3,5)P2, which is involved in
vacuolar sorting and homeostasis"
/codon_start=1
/product="1-phosphatidylinositol-3-phosphate 5-kinase"
/protein_id="NP_116674.2"
/db_xref="GeneID:850574"
/db_xref="SGD:S000001915"
/translation="MSSEEPHASISFPDGSHVRSSSTGTSSVNTIDATLSRPNYIKKP
SLHIMSTSTTSTTTDLVTNPILSNISVPKISPPTSSSIATATSTSHVTGTASHSNIKA
NANTSTSVNKKNLPPTTSGRIPSSTIKRYPSRYKPSHSLQLPIKNDSNFKRSSIYASK
STVTAIPIRNNRPISMQNSYARTPDSDHDDVGDEVSSIKSASSSLTASLSKSFLFAFY
NNRKKDKTSNNGVLSKEYWMKDESSKECFSCGKTFNTFRRKHHCRICGQIFCSSCTLL
IDGDRFGCHAKMRVCYNCYEHADTYEDSSDEENDSTMQLNEPRSRSRSRSSNTNPYSH
SHSHLHLISQDNHNGTDLHDPVAATDNPQQQNEVYLLNDDDVQSIMTSGEDSKLFIST
PPPPPKMAIPATKQGGSLEISFDSENDRALHYQDDNPGRHHHLDSVPTRYTIRDMDNI
SHYDTNSNSTLRPHYNTNNSTITINNLNNTTSNNSNYNNTNSNSNINNPAHSLRRSIF
HYVSSNSVNKDSNNSSATPASSAQSSSILDPANRIIGNYAHRNYKFKFNYNSKGPSQQ
NDTANGNNDNNNNNNNNNNNNNNNSASGIADNNNIPSNDNGTTFTLDKKKRNPLTKSK
STSAYLEYPLNEEDSSEDEGSMSIYSVLNDDHKTDNPIRSMRNSTKSFQRAQASLQRM
RFRRKSKSKHFPNNSKSSIYRDLNFLTNSTPNLLSVVSDDNLYDDSSPLQDKASSSAA
SRLTDRKFSNSSGSNNNSNSNSNINTDPWKRIASISGFKLKKEKKRELNEVSLLHMHA
LLKQLLNDQEISNLQEWITLLDGALRKVLRTILNARDLNTLDFRQTYVKIKRISGGSP
QNSEYIDGVVFSKALPSKTMPRHLKNPRILLIMFPLEYQKNNNHFLSIESVFRQEREY
LDKLVSRLKSLHPDIIYVGANVSGYALELLNDSGIVVQFNMKPQVIERIAKLTEADIA
ISVDKLATNIKMGECETFEVKSYIYGNISKTYTFLRGCNPELGGTILLRGDSLENLRK
IKQVSEFMVYAIFSLKLESSFFNDNFIQLSTDVYLKRAESKKLQVFEGYFADFLIKFN
NRILTVSPTVDFPIPFLLEKARGLEKKLIERINQYESESDLDRQTQLNMLQGLESTIT
KKHLGNLIKFLHEMEIENLELEFQKRSRQWEVSYSSSQNLLGTGSHQSITVLYSMVST
KTATPCVGPQIVTIDYFWDSDISIGQFIENVVGTARYPCQQGCNGLYLDHYRSYVHGS
GKVDVLIEKFQTRLPKLKDIILTWSYCKKCGTSTPILQISEKTWNHSFGKYLEVMFWS
YKDSVTGIGKCPHDFTKDHVKYFGYNDLVVRLEYSDLEVHELITPPRKIKWKPHIDIK
LKVELYYKILEKINNFYGSVLSRLERIKLDSMTKDKVLSGQAKIIELKSNATEEQKLM
LQDLDTFYADSPCDQHLPLNLVIKSLYDKAVNWNSTFAIFAKSYLPSETDISRITAKQ
LKKLFYDSSRKDSEDKKSLHDEKAKTRKPEKNELPLEGLKDVEKPKIDSKNTTENRDR
TNEPQNAVTITTFKDDTPIIPTSGTSHLTVTPSASSVSSSLTPQTEERPPISRSGTGI
SMTHDKSTRPNIRKMSSDSSLCGLASLANEYSKNNKVSKLATFFDQMHFDALSKEFEL
ERERERLQLNKDKYQAIRLQTSTPIVEIYKNVKDAVDEPLHSRSSGNNLSSANVKTLE
APVGEHSRANNCNPPNLDQNLETELENSISQWGENILNPSGKTTASTHLNSKPVVKET
SENPKSIVRESDNSKSEPLPPVITTTTVNKVESTPQPEKSLLMKTLSNFWADRSAYLW
KPLVYPTCPSEHIFTDSDVIIREDEPSSLIAFCLSTSDYRNKMMNLNVQQQQQQQTAE
AAPAKTGGNSGGTTQTGDPSVNISPSVSTTSHNKGRDSEISSLVTTKEGLLNTPPIEG
ARDRTPQESQTHSQANLDTLQELEKIMTKKTATHLRYQFEEGLTVMSCKIFFTEHFDV
FRKICDCQENFIQSLSRCVKWDSNGGKSGSGFLKTLDDRFIIKELSHAELEAFIKFAP
SYFEYMAQAMFHDLPTTLAKVFGFYQIQVKSSISSSKSYKMDVIIMENLFYEKKTTRI
FDLKGSMRNRHVEQTGKANEVLLDENMVEYIYESPIHVREYDKKLLRASVWNDTLFLA
KMNVMDYSLVIGIDNEGYTLTVGIIDFIRTFTWDKKLESWVKEKGLVGGASVIKQPTV
VTPRQYKKRFREAMERYILMVPDPWYREGN"
gene complement(191513..191613)
/locus_tag="YNCF0009C"
/db_xref="GeneID:850575"
tRNA complement(join(191513..191557,191577..191613))
/locus_tag="YNCF0009C"
/product="tRNA-Ser"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Serine tRNA (tRNA-Ser), predicted by tRNAscan-SE
analysis"
/db_xref="GeneID:850575"
/db_xref="SGD:S000006731"
repeat_region complement(191685..191854)
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006932"
gene <192737..>193435
/gene="CSS2"
/locus_tag="YFR020W"
/db_xref="GeneID:850576"
mRNA <192737..>193435
/gene="CSS2"
/locus_tag="YFR020W"
/product="Css2p"
/transcript_id="NM_001270745.1"
/db_xref="GeneID:850576"
CDS 192737..193435
/gene="CSS2"
/locus_tag="YFR020W"
/experiment="EXISTENCE:direct assay:GO:0005576
extracellular region [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/note="hypothetical protein, secreted when constitutively
expressed; SWAT-GFP fusion protein localizes to the
endoplasmic reticulum (ER) and extracellular region, while
mCherry fusion protein localizes to the ER and vacuole;
mRNA identified as translated by ribosome profiling data;
CSS2 is a non-essential gene"
/codon_start=1
/product="Css2p"
/protein_id="NP_001257674.1"
/db_xref="GeneID:850576"
/db_xref="SGD:S000001916"
/translation="MWCYSHFLLIFVSFVTSFAHKLPANNSTTNGGTDGIAVPVIETT
IDSGMYSENGTDLMTPEDLPDLLSDGIVLSFANTTETGSDSDSTLIDSEDLRRCIDMP
DRSCSAQRGNLCSYSFWDIPFSFLNTVHDIFGMTNMGNCAVMAGDKGAFYYKYYPVEP
NCNSTIHQKTIDDALQQATEQLNGDFNNMYFFHVNRGGLWQGDMMVGTRVFTWFAGAK
WAEHKGSIEAGFTS"
gene <194812..>196314
/gene="ATG18"
/locus_tag="YFR021W"
/gene_synonym="AUT10; CVT18; NMR1; SVP1"
/db_xref="GeneID:850577"
mRNA <194812..>196314
/gene="ATG18"
/locus_tag="YFR021W"
/gene_synonym="AUT10; CVT18; NMR1; SVP1"
/product="phosphoinositide binding protein ATG18"
/transcript_id="NM_001179986.1"
/db_xref="GeneID:850577"
CDS 194812..196314
/gene="ATG18"
/locus_tag="YFR021W"
/gene_synonym="AUT10; CVT18; NMR1; SVP1"
/experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
vacuole membrane
[PMID:15103325|PMID:22842922|PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0000407 phagophore
assembly site [PMID:18497569]"
/experiment="EXISTENCE:direct assay:GO:0005768 endosome
[PMID:18769150]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:11707261]"
/experiment="EXISTENCE:direct assay:GO:0006624 vacuolar
protein processing [PMID:11707261]"
/experiment="EXISTENCE:direct assay:GO:0016236
macroautophagy [PMID:11707261]"
/experiment="EXISTENCE:direct assay:GO:0032258 cytoplasm
to vacuole transport by the Cvt pathway [PMID:11707261]"
/experiment="EXISTENCE:direct assay:GO:0032266
phosphatidylinositol-3-phosphate binding
[PMID:15103325|PMID:15155809]"
/experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin
binding [PMID:21070969]"
/experiment="EXISTENCE:direct assay:GO:0061908 phagophore
[PMID:23549786]"
/experiment="EXISTENCE:direct assay:GO:0070273
phosphatidylinositol-4-phosphate binding [PMID:15155809]"
/experiment="EXISTENCE:direct assay:GO:0070772 PAS complex
[PMID:19037259]"
/experiment="EXISTENCE:direct assay:GO:0071944 cell
periphery [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0080025
phosphatidylinositol-3,5-bisphosphate binding
[PMID:15103325]"
/experiment="EXISTENCE:mutant phenotype:GO:0006624
vacuolar protein processing [PMID:11707261]"
/experiment="EXISTENCE:mutant phenotype:GO:0016236
macroautophagy [PMID:11707261]"
/experiment="EXISTENCE:mutant phenotype:GO:0030242
autophagy of peroxisome [PMID:11739783]"
/experiment="EXISTENCE:mutant phenotype:GO:0032258
cytoplasm to vacuole transport by the Cvt pathway
[PMID:11707261|PMID:16876790]"
/experiment="EXISTENCE:mutant phenotype:GO:0034727
piecemeal microautophagy of the nucleus [PMID:18701704]"
/experiment="EXISTENCE:mutant phenotype:GO:0044090
positive regulation of vacuole organization
[PMID:17699591]"
/experiment="EXISTENCE:mutant phenotype:GO:0044805 late
nucleophagy [PMID:22768199]"
/experiment="EXISTENCE:mutant phenotype:GO:0045324 late
endosome to vacuole transport [PMID:15103325]"
/experiment="EXISTENCE:physical interaction:GO:0070772 PAS
complex [PMID:19037259]"
/note="Phosphoinositide binding protein; required for
vesicle formation in autophagy and the
cytoplasm-to-vacuole targeting (CVT) pathway; binds
PtdIns(3,5)P2, PI3P and PI4P; WD-40 repeat containing
protein and PROPPIN family member; relocalizes from the
vacuole to cytoplasm upon DNA replication stress;
mammalian homologs include: WIPI1, WIPI2, WIPI3 and
WIPI4/WDR45; mutations in human WDR45 cause static
encephalopathy of childhood with neurodegeneration in
adulthood (SENDA)"
/codon_start=1
/product="phosphoinositide binding protein ATG18"
/protein_id="NP_444297.1"
/db_xref="GeneID:850577"
/db_xref="SGD:S000001917"
/translation="MSDSSPTINFINFNQTGTCISLGTSKGFKIFNCEPFGKFYSEDS
GGYAIVEMLFSTSLLALVGIGDQPALSPRRLRIINTKKHSIICEVTFPTSILSVKMNK
SRLVVLLQEQIYIYDINTMRLLHTIETNPNPRGLMAMSPSVANSYLVYPSPPKVINSE
IKAHATTNNITLSVGGNTETSFKRDQQDAGHSDISDLDQYSSFTKRDDADPTSSNGGN
SSIIKNGDVIVFNLETLQPTMVIEAHKGEIAAMAISFDGTLMATASDKGTIIRVFDIE
TGDKIYQFRRGTYATRIYSISFSEDSQYLAVTGSSKTVHIFKLGHSMSNNKLDSDDSN
MEEAAADDSSLDTTSIDALSDEENPTRLAREPYVDASRKTMGRMIRYSSQKLSRRAAR
TLGQIFPIKVTSLLESSRHFASLKLPVETNSHVMTISSIGSPIDIDTSEYPELFETGN
SASTESYHEPVMKMVPIRVVSSDGYLYNFVMDPERGGDCLILSQYSILMD"
gene <196833..>199034
/gene="ROG3"
/locus_tag="YFR022W"
/gene_synonym="ART7"
/db_xref="GeneID:850578"
mRNA <196833..>199034
/gene="ROG3"
/locus_tag="YFR022W"
/gene_synonym="ART7"
/product="Rog3p"
/transcript_id="NM_001179987.3"
/db_xref="GeneID:850578"
CDS 196833..199034
/gene="ROG3"
/locus_tag="YFR022W"
/gene_synonym="ART7"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0031625 ubiquitin
protein ligase binding [PMID:24820415]"
/experiment="EXISTENCE:genetic interaction:GO:0000754
adaptation of signaling pathway by response to pheromone
involved in conjugation with cellular fusion
[PMID:24820415]"
/experiment="EXISTENCE:genetic interaction:GO:0002092
positive regulation of receptor internalization
[PMID:24820415]"
/experiment="EXISTENCE:mutant phenotype:GO:0000754
adaptation of signaling pathway by response to pheromone
involved in conjugation with cellular fusion
[PMID:24820415]"
/experiment="EXISTENCE:mutant phenotype:GO:0031625
ubiquitin protein ligase binding [PMID:24820415]"
/experiment="EXISTENCE:physical interaction:GO:0031625
ubiquitin protein ligase binding [PMID:18976803]"
/note="Alpha-arrestin involved in ubiquitin-dependent
endocytosis; contributes to desensitization of
agonist-occupied alpha-factor receptor Ste2p by
Rsp5p-independent internalization; PPXY motif-mediated
binding of the ubiquitin ligase Rsp5p is not required for
adaptation; mutation suppresses the temperature
sensitivity of an mck1 rim11 double mutant; SWAT-GFP and
mCherry fusion proteins localize to the cytosol; ROG3 has
a paralog, ROD1, that arose from the whole genome
duplication"
/codon_start=1
/product="Rog3p"
/protein_id="NP_116677.3"
/db_xref="GeneID:850578"
/db_xref="SGD:S000001918"
/translation="MGFSSGKSTKKKPLLFDIRLKNVDNDVILLKGPPNEAPSVLLSG
CIVLSINEPMQIKSISLRLYGKIQIDVPLERPQDASSSSLSSSPPKIRKYNKVFYNYA
WDNVNLKEYLSGLRGQSGLAGSSSSSNILGTRQRAQSTSSLKSLKGSSSPSSCTLDKG
NYDFPFSAILPGSLPESVESLPNCFVTYSMESVIERSKNYSDLICRKNIRVLRTISPA
AVELSETVCVDNSWPDKVDYSISVPNKAVAIGSATPINISIVPLSKGLKLGSIKVVLF
ENYQYCDPFPPVISENRQVTELNLEDPLNESSGEFNGNGCFVNNPFFQPDHSFQDKWE
IDTILQIPNSLSNCVQDCDVRSNIKVRHKLKFFIILINPDGHKSELRASLPIQLFISP
FVALSIKPLSSSNLYSLFSTTNQKDENSSQEEEEEYLFSRSASVTGLELLADMRSGGS
VPTISDLMTPPNYEMHVYDRLYSGSFTRTAVETSGTCTPLGSECSTVEDQQQDLEDLR
IRLTKIRNQRDNLGLPPSASSAAASRSLSPLLNVPAPEDGTERILPQSALGPNSGSVP
GVHSNVSPVLLSRSPAPSVSAHEVLPVPSGLNYPETQNLNKVPSYGKAMKYDIIGEDL
PPSYPCAIQNVQPRKPSRVHSRNSSTTLSSSIPTSFHSSSFMSSTASPISIINGSRSS
SSGVSLNTLNELTSKTSNNPSSNSMKRSPTRRRATSLAGFMGGFLSKGNKR"
gene complement(199299..199813)
/gene="RUF22"
/locus_tag="YNCF0010C"
/db_xref="GeneID:9164891"
ncRNA complement(199299..199813)
/ncRNA_class="other"
/gene="RUF22"
/locus_tag="YNCF0010C"
/product="RUF22"
/note="RNA of Unknown Function; precise location of 3' end
uncertain; RUF22 may be longer than currently annotated"
/transcript_id="NR_132174.1"
/db_xref="GeneID:9164891"
/db_xref="SGD:S000130131"
rep_origin 199395..199505
/note="ARS607; Highly-efficient autonomously replicating
sequence on Chromosome VI; activated very early in S phase
in >85% of cell cycles"
/db_xref="SGD:S000007639"
gene <199874..>201709
/gene="PES4"
/locus_tag="YFR023W"
/db_xref="GeneID:850579"
mRNA <199874..>201709
/gene="PES4"
/locus_tag="YFR023W"
/product="Pes4p"
/transcript_id="NM_001179988.1"
/db_xref="GeneID:850579"
CDS 199874..201709
/gene="PES4"
/locus_tag="YFR023W"
/experiment="EXISTENCE:direct assay:GO:0005628 prospore
membrane [PMID:28193845]"
/experiment="EXISTENCE:genetic interaction:GO:0006417
regulation of translation [PMID:28193845]"
/experiment="EXISTENCE:genetic interaction:GO:0010609 mRNA
localization resulting in post-transcriptional regulation
of gene expression [PMID:28193845]"
/experiment="EXISTENCE:genetic interaction:GO:0016071 mRNA
metabolic process [PMID:28193845]"
/note="Putative RNA binding protein; partially redundant
function with paralog MIP6 in the steady-state expression,
translational timing and localization of a subset of
Ndt80-dependent mRNAs that are protected until translated
near the end of meiosis II; regulator of meiotic
commitment; redundant function with MIP6 in sporulation;
localizes to puncta near the openings of the prospore
membrane; suppressor of a DNA polymerase epsilon mutation;
induced by NDT80"
/codon_start=1
/product="Pes4p"
/protein_id="NP_116678.1"
/db_xref="GeneID:850579"
/db_xref="SGD:S000001919"
/translation="MYSISNKKPSILSMVPLNILKNQDLKVKKDQEKKISFNPVVTPI
RPDDYHEKTSRSSSSSHSDSPEFLRINNNKSGHKNGKLKSFESKKLVPLFIGDLHETV
TEETLKGIFKKYPSFVSAKVCLDSVTKKSLGHGYLNFEDKEEAEKAMEELNYTKVNGK
EIRIMPSLRNTTFRKNFGTNVFFSNLPLNNPLLTTRVFYDTFSRYGKILSCKLDSRKD
IGFVYFEDEKTARNVIKMYNNTSFFGKKILCGIHFDKEVRSVPNFETQKSRLDAETII
EKEQSLNEKHSKGNDKESKNIYSSSQNSIFIKNLPTITTRDDILNFFSEVGPIKSIYL
SNATKVKYLWAFVTYKNSSDSEKAIKRYNNFYFRGKKLLVTRAQDKEERAKFIESQKI
STLFLENLSAVCNKEFLKYLCHQENIRPFKIQIDGYDENSSTYSGFIKFRNFEDATRI
FNFLNNRLVGGSIVTTSWERQNNAPKYHDGYGMRNIHTSSHPQITPYYQYSHANSLNS
PHMRDLSSMNSSTRSLIKNKNFNKKVLETFEKQVRRGIDFMRFPSATRDENVHGIAEY
IFDTYWNRDVLILDKFLSLLNSSPYHEGVLQKQIEEAASSLGFKR"
gene complement(<201960..>203433)
/gene="LSB3"
/locus_tag="YFR024C-A"
/gene_synonym="YFR024C"
/db_xref="GeneID:850580"
mRNA complement(join(<201960..203292,203387..>203433))
/gene="LSB3"
/locus_tag="YFR024C-A"
/gene_synonym="YFR024C"
/product="Lsb3p"
/transcript_id="NM_001180865.3"
/db_xref="GeneID:850580"
CDS complement(join(201960..203292,203387..203433))
/gene="LSB3"
/locus_tag="YFR024C-A"
/gene_synonym="YFR024C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0051666
actin cortical patch localization [PMID:19158382]"
/experiment="EXISTENCE:mutant phenotype:GO:0051666 actin
cortical patch localization [PMID:19158382]"
/note="Protein containing a C-terminal SH3 domain; binds
Las17p, which is a homolog of human Wiskott-Aldrich
Syndrome protein involved in actin patch assembly and
actin polymerization; protein abundance increases in
response to DNA replication stress; LSB3 has a paralog,
YSC84, that arose from the whole genome duplication"
/codon_start=1
/product="Lsb3p"
/protein_id="NP_219497.4"
/db_xref="GeneID:850580"
/db_xref="SGD:S000002968"
/translation="MGINNPIPRSLKSETKKAAKILASFVKPNQVFGADQVIPPDVLK
RAKGLAIITILKAGFLFSGRAGSGVIVARLKDGTWSAPSAIAMAGAGAGGMVGIELTD
FVFILNTQDAVKSFSEFGTITLGGNVSVSAGPLGRSAEAAASASAGGVAAVFAYSKSK
GLFAGVSVEGSAIIERREANRKFYGDNCTAKMILSGRIRPPPAVDPLFRVLESRAFNY
RPSNGGRGSFDDDEDDYYDDDDYYNDIPSSFSSTDASSTRPNTRSTRRRAQSGSRYTF
DDDDDDDDYGTGYSRNSRLAPTNSGGSGGKLDDPSGASSYYASHRRSGTAQSRARSSR
NRWADDEYDDYDDDYESGYRRGNGRDRTKDREVDDLSNRFSKSRISSASTPQTSQGRF
TAPTSPSTSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGI
FPANYVELV"
gene complement(<203743..>204750)
/gene="HIS2"
/locus_tag="YFR025C"
/db_xref="GeneID:850581"
mRNA complement(<203743..>204750)
/gene="HIS2"
/locus_tag="YFR025C"
/product="histidinol-phosphatase"
/transcript_id="NM_001179990.1"
/db_xref="GeneID:850581"
CDS complement(203743..204750)
/gene="HIS2"
/locus_tag="YFR025C"
/EC_number="3.1.3.15"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:mutant phenotype:GO:0000105
histidine biosynthetic process [PMID:14190241]"
/experiment="EXISTENCE:mutant phenotype:GO:0004401
histidinol-phosphatase activity [PMID:14190241]"
/note="Histidinolphosphatase; catalyzes the eighth step in
histidine biosynthesis; mutations cause histidine
auxotrophy and sensitivity to Cu, Co, and Ni salts;
transcription is regulated by general amino acid control"
/codon_start=1
/product="histidinol-phosphatase"
/protein_id="NP_116681.1"
/db_xref="GeneID:850581"
/db_xref="SGD:S000001921"
/translation="MHSHHSHSGDYSAHGTDPLDSVVDQVVNLNFHTYCLTEHIPRIE
AKFIYPEEQSLGKNPEEVITKLETSFKNFMSHAQEIKTRYADRPDVRTKFIIGMEIES
CDMAHIEYAKRLMKENNDILKFCVGSVHHVNGIPIDFDQQQWYNSLHSFNDNLKHFLL
SYFQSQYEMLINIKPLVVGHFDLYKLFLPNDMLVNQKSGNCNEETGVPVASLDVISEW
PEIYDAVVRNLQFIDSYGGAIEINTSALRKRLEEPYPSKTLCNLVKKHCGSRFVLSDD
AHGVAQVGVCYDKVKKYIVDVLQLEYICYLEESQSPENLLTVKRLPISQFVNDPFWAN
I"
gene complement(204924..204996)
/locus_tag="YNCF0011C"
/db_xref="GeneID:850582"
tRNA complement(204924..204996)
/locus_tag="YNCF0011C"
/product="tRNA-Ala"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Alanine tRNA (tRNA-Ala), predicted by tRNAscan-SE
analysis; one of 11 nuclear tRNA genes containing the
tDNA-anticodon AGC (converted to IGC in the mature tRNA),
decodes GCU and GCC codons into alanine, one of 16 nuclear
tRNAs for alanine"
/db_xref="GeneID:850582"
/db_xref="SGD:S000006511"
gene complement(<205748..>206257)
/gene="ULI1"
/locus_tag="YFR026C"
/db_xref="GeneID:850583"
mRNA complement(<205748..>206257)
/gene="ULI1"
/locus_tag="YFR026C"
/product="Uli1p"
/transcript_id="NM_001179991.3"
/db_xref="GeneID:850583"
CDS complement(205748..206257)
/gene="ULI1"
/locus_tag="YFR026C"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0030968
endoplasmic reticulum unfolded protein response
[PMID:19073890]"
/note="hypothetical protein; involved in and induced by
the endoplasmic reticulum unfolded protein response (UPR);
SWAT-GFP and mCherry fusion proteins localize to the
endoplasmic reticulum"
/codon_start=1
/product="Uli1p"
/protein_id="NP_116682.3"
/db_xref="GeneID:850583"
/db_xref="SGD:S000001922"
/translation="MTPYAVAITVALLIVTVSALQVNNSCVAFPPSNLRGKNGDGTNE
QYATALLSIPWNGPPESLRDINLIELEPQVALYLLENYINHYYNTTRDNKCPNNHYLM
GGQLGSSSDNRSLNDPQTMLWPEKKEDEKNCQETFKGACSCTKRFCKGYFSVNIFGIN
LNISYSSGK"
repeat_region 206922..207138
/note="Ty1 LTR"
/rpt_type=long_terminal_repeat
/db_xref="SGD:S000006934"
gene <207452..>208297
/gene="ECO1"
/locus_tag="YFR027W"
/gene_synonym="CTF7"
/db_xref="GeneID:850584"
mRNA <207452..>208297
/gene="ECO1"
/locus_tag="YFR027W"
/gene_synonym="CTF7"
/product="Eco1p"
/transcript_id="NM_001179992.1"
/db_xref="GeneID:850584"
CDS 207452..208297
/gene="ECO1"
/locus_tag="YFR027W"
/gene_synonym="CTF7"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:22842922]"
/experiment="EXISTENCE:direct assay:GO:0006281 DNA repair
[PMID:11448778]"
/experiment="EXISTENCE:direct assay:GO:0016407
acetyltransferase activity
[PMID:11864574|PMID:18614053|PMID:22593213]"
/experiment="EXISTENCE:direct assay:GO:0018393 internal
peptidyl-lysine acetylation [PMID:18614053]"
/experiment="EXISTENCE:direct assay:GO:0043596 nuclear
replication fork [PMID:16962805]"
/experiment="EXISTENCE:genetic interaction:GO:0034087
establishment of mitotic sister chromatid cohesion
[PMID:16934511]"
/experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA
replication [PMID:9990856]"
/experiment="EXISTENCE:mutant phenotype:GO:0006302
double-strand break repair [PMID:11448778]"
/experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic
chromosome condensation [PMID:19948494]"
/experiment="EXISTENCE:mutant phenotype:GO:0016407
acetyltransferase activity [PMID:22593213]"
/experiment="EXISTENCE:mutant phenotype:GO:0032200
telomere organization [PMID:19948494]"
/experiment="EXISTENCE:mutant phenotype:GO:0034087
establishment of mitotic sister chromatid cohesion
[PMID:9990855|PMID:9990856]"
/experiment="EXISTENCE:mutant phenotype:GO:0034089
establishment of meiotic sister chromatid cohesion
[PMID:35103590]"
/experiment="EXISTENCE:mutant phenotype:GO:0051276
chromosome organization [PMID:19948494]"
/experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA
gene clustering [PMID:19948494]"
/experiment="EXISTENCE:mutant phenotype:GO:0140588
chromatin looping [PMID:32032532]"
/note="Acetyltransferase required for sister chromatid
cohesion; elicits cohesin dimerization during S phase;
acetylates Mps3p to regulate nuclear organization;
modifies Smc3p at replication forks and Mcd1p in response
to dsDNA breaks; phosphorylated by Cdc28p, Cdc7p, Mck1p to
generate pair of phosphates spaced precisely for
recognition by ubiquitin ligase SCF-Cdc4; relative
distribution to nucleus increases upon DNA replication
stress; mutations in human homolog ESCO2 cause Roberts
syndrome"
/codon_start=1
/product="Eco1p"
/protein_id="NP_116683.1"
/db_xref="GeneID:850584"
/db_xref="SGD:S000001923"
/translation="MKARKSQRKAGSKPNLIQSKLQVNNGSKSNKIVKCDKCEMSYSS
TSIEDRAIHEKYHTLQLHGRKWSPNWGSIVYTERNHSRTVHLSRSTGTITPLNSSPLK
KSSPSITHQEEKIVYVRPDKSNGEVRAMTEIMTLVNNELNAPHDENVIWNSTTEEKGK
AFVYIRNDRAVGIIIIENLYGGNGKTSSRGRWMVYDSRRLVQNVYPDFKIGISRIWVC
RTARKLGIATKLIDVARENIVYGEVIPRYQVAWSQPTDSGGKLASKYNGIMHKSGKLL
LPVYI"
gene complement(<208413..>210068)
/gene="CDC14"
/locus_tag="YFR028C"
/gene_synonym="OAF3"
/db_xref="GeneID:850585"
mRNA complement(<208413..>210068)
/gene="CDC14"
/locus_tag="YFR028C"
/gene_synonym="OAF3"
/product="phosphoprotein phosphatase CDC14"
/transcript_id="NM_001179993.3"
/db_xref="GeneID:850585"
CDS complement(208413..210068)
/gene="CDC14"
/locus_tag="YFR028C"
/gene_synonym="OAF3"
/EC_number="3.1.3.48"
/experiment="EXISTENCE:direct assay:GO:0004721
phosphoprotein phosphatase activity
[PMID:9295359|PMID:17173039|PMID:24319056|PMID:24954044]"
/experiment="EXISTENCE:direct assay:GO:0004722 protein
serine/threonine phosphatase activity
[PMID:26085509|PMID:35238874]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276|PMID:26090959]"
/experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
[PMID:36259662|PMID:12062061|PMID:26090959]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:26090959]"
/experiment="EXISTENCE:direct assay:GO:0005816 spindle
pole body [PMID:12062061]"
/experiment="EXISTENCE:direct assay:GO:0005935 cellular
bud neck [PMID:36259662]"
/experiment="EXISTENCE:direct assay:GO:0010508 positive
regulation of autophagy [PMID:35238874]"
/experiment="EXISTENCE:direct assay:GO:0030869 RENT
complex [PMID:10219244]"
/experiment="EXISTENCE:direct assay:GO:0044732 mitotic
spindle pole body [PMID:36259662]"
/experiment="EXISTENCE:direct assay:GO:0071958 new mitotic
spindle pole body [PMID:36259662]"
/experiment="EXISTENCE:direct assay:GO:0140013 meiotic
nuclear division [PMID:35238874]"
/experiment="EXISTENCE:genetic interaction:GO:1903501
positive regulation of mitotic actomyosin contractile ring
assembly [PMID:26085509]"
/experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic
cell cycle [PMID:6749599]"
/experiment="EXISTENCE:mutant phenotype:GO:0000422
autophagy of mitochondrion [PMID:29694832]"
/experiment="EXISTENCE:mutant phenotype:GO:0007059
chromosome segregation [PMID:16769819]"
/experiment="EXISTENCE:mutant phenotype:GO:0007096
regulation of exit from mitosis [PMID:10219244]"
/experiment="EXISTENCE:mutant phenotype:GO:0016479
negative regulation of transcription by RNA polymerase I
[PMID:19158678]"
/experiment="EXISTENCE:mutant phenotype:GO:0032467
positive regulation of cytokinesis [PMID:25371407]"
/experiment="EXISTENCE:mutant phenotype:GO:0051229 meiotic
spindle disassembly [PMID:12737806]"
/experiment="EXISTENCE:mutant phenotype:GO:0071470
cellular response to osmotic stress [PMID:25411400]"
/experiment="EXISTENCE:mutant phenotype:GO:1903501
positive regulation of mitotic actomyosin contractile ring
assembly [PMID:26085509]"
/experiment="EXISTENCE:mutant phenotype:GO:2000786
positive regulation of autophagosome assembly
[PMID:29694832]"
/note="Protein phosphatase required for mitotic exit;
required for rDNA segregation, cytokinesis, meiosis I
spindle disassembly, environmental stress response,
autophagy during meiosis; downregulates microautophagy
induction after TORC1 inactivation; held in nucleolus by
Cdc55p in early meiosis, liberated by FEAR and Mitotic
Exit Network in anaphase; sequestered in metaphase II,
released upon entry into anaphase II; human homolog CDC14A
can complement thermosensitivity of cdc14-1 mutant"
/codon_start=1
/product="phosphoprotein phosphatase CDC14"
/protein_id="NP_116684.3"
/db_xref="GeneID:850585"
/db_xref="SGD:S000001924"
/translation="MRRSVYLDNTIEFLRGRVYLGAYDYTPEDTDELVFFTVEDAIFY
NSFHLDFGPMNIGHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANAACMLCCYM
ILVQAWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGLIDLH
SFNLESYEKYEHVEFGDFNVLTPDFIAFASPQEDHPKGYLATKSSHLNQPFKSVLNFF
ANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVKNFVGAAETIIKRG
GKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFLRFIRPGMVVGPQQHWLYLHQN
DFREWKYTTRISLKPSEAIGGLYPLISLEEYRLQKKKLKDDKRVAQNNIEGELRDLTM
TPPSNGHGALSARNSSQPSTANNGSNSFKSSAVPQTSPGQPRKGQNGSNTIEDINNNR
NPTSHANRKVVIESNNSDDESMQDTNGTSNHYPKVSRKKNDISSASSSRMEDNEPSAT
NINNAADDTILRQLLPKNRRVTSGRRTTSAAGGIRKISGSIKK"
gene complement(210619..210707)
/gene="SUP6"
/locus_tag="YNCF0012C"
/db_xref="GeneID:850586"
tRNA complement(join(210619..210654,210669..210707))
/gene="SUP6"
/locus_tag="YNCF0012C"
/product="tRNA-Tyr"
/experiment="EXISTENCE:curator inference:GO:0005829
cytosol [PMID:9023104]"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/note="Tyrosine tRNA (tRNA-Tyr), predicted by tRNAscan-SE
analysis; can mutate to suppress ochre nonsense mutations"
/db_xref="GeneID:850586"
/db_xref="SGD:S000006780"
gene <210937..>212973
/gene="PTR3"
/locus_tag="YFR029W"
/gene_synonym="RAA2; SSY3"
/db_xref="GeneID:850587"
mRNA <210937..>212973
/gene="PTR3"
/locus_tag="YFR029W"
/gene_synonym="RAA2; SSY3"
/product="Ptr3p"
/transcript_id="NM_001179994.1"
/db_xref="GeneID:850587"
CDS 210937..212973
/gene="PTR3"
/locus_tag="YFR029W"
/gene_synonym="RAA2; SSY3"
/experiment="EXISTENCE:direct assay:GO:0005886 plasma
membrane [PMID:10409731]"
/experiment="EXISTENCE:mutant phenotype:GO:0043200
response to amino acid [PMID:10409731]"
/note="Component of the SPS plasma membrane amino acid
sensor system; senses external amino acid concentration
and transmits intracellular signals that result in
regulation of expression of amino acid permease genes;
other members are Ssy1p, Ptr3p, and Ssy5p"
/codon_start=1
/product="Ptr3p"
/protein_id="NP_116685.1"
/db_xref="GeneID:850587"
/db_xref="SGD:S000001925"
/translation="MHSHRQKWGRQTDIARVLDDIEHDLYLPQRLSLDGATGTDESHV
QYGIVKDCSVLTCGCCISESLFNDLCRETSNKQTACPICQRENVRLLSAIKPLRDLAR
QIDFFRSTTGQGESESDELPAIVKTSPSSSSLSLTPSRSSSTAGLEADNKTLSDPTVK
EKSSLLELFHIVASKMHNANTEVGSDHPLTTGTTRDQEEHTTKENYSSSLLEPNYDDH
ANWKILDNASNTRTVPIDNNFSLMSTDVTIPSTANYQTNSAHDLDEEKEYFFANCFPM
YRKKFQFNTHPKFLGTKSKLFINQSISPDCTKFALITEHKWEIYSINPKDNSPQLVSC
GKSSGEYGPNFNQLTEQSSSSLSTTSQASKKKKKNWSQRFCKLSNDFLIISGSQNILN
VHDIHQNGKLIYTYVSRFPIRCIDIDPRSQIIAYGITGKDRHTGAEQALVVIQQITRN
KVTLEPEFPPPITITLPYRDPINTIQLSHDAKYLTCSTALESRFLIISLQKINEPRLI
MKSVRSIDTSLESEGITDTKLFPGNPNLMCITSTAFNSSPLVINTKITQINGVRTVAQ
PSMLIRVDEIGCKIHKCEISPRNDAIAFLDRNGSVYIMCAPTMMDNNEKRRTILVETV
ANAYRAYESATLRFNPEGNKLYILDRKGTFFVEDFAYGLPQSREITKCKQIFHK"
gene <213312..>216419
/gene="MET10"
/locus_tag="YFR030W"
/db_xref="GeneID:850588"
mRNA <213312..>216419
/gene="MET10"
/locus_tag="YFR030W"
/product="sulfite reductase subunit alpha"
/transcript_id="NM_001179995.3"
/db_xref="GeneID:850588"
CDS 213312..216419
/gene="MET10"
/locus_tag="YFR030W"
/EC_number="1.8.1.2"
/experiment="EXISTENCE:direct assay:GO:0004783 sulfite
reductase (NADPH) activity [PMID:6751400]"
/experiment="EXISTENCE:direct assay:GO:0009337 sulfite
reductase complex (NADPH) [PMID:6751400]"
/experiment="EXISTENCE:mutant phenotype:GO:0000103 sulfate
assimilation [PMID:19236486|PMID:7928966]"
/note="Subunit alpha of assimilatory sulfite reductase;
complex converts sulfite into sulfide"
/codon_start=1
/product="sulfite reductase subunit alpha"
/protein_id="NP_116686.3"
/db_xref="GeneID:850588"
/db_xref="SGD:S000001926"
/translation="MPVEFATNPFGEAKNATSLPKYGTPVTAISSVLFNNVDSIFAYK
SFSQPDLLHQDLKKWSEKRGNESRGKPFFQELDIRSGAGLAPLGFSHGLKNTTAIVAP
GFSLPYFINSLKTVSHDGKFLLNVGALNYDNATGSVTNDYVTALDAASKLKYGVVTPI
SANEVQSVALLALAIATFSNNSGAINLFDGLNYSKTVLPLVESVPEASILAKLSKVIA
PDAAFDDVLDKFNELTGLRLHNFQYFGAQDAETVFITYGSLESELFNSAISGNNSKIG
LINVRVPLPFNVAKFVTHVPSTTKQIVVIGQTLDGSSPSFLRSQVSAALFYHGRTSIS
VSEYIYQPDFIWSPKAVKSIVSSFIPEFTYNADSSFGEGFIYWASDKSINIDVASKLV
KALSLEDGKFVSLRTKFDNLANAGTFQAQFVTSKEQIPVSNIDSTKLSVVEDVSLLKH
LDVAATVAEQGSIALVSQKAVKDLDLNSVESYVKNLGIPESFLISIAKKNIKLFIIDG
ETTNDESKLSLFIQAVFWKLAFGLDVAECTNRIWKSIDSGADISAASISEFLTGAFKN
FLSEVPLALYTKFSEINIEKKEDEEEPAALPIFVNETSFLPNNSTIEEIPLPETSEIS
DIAKKLSFKEAYEVENKLRPDLPVKNFVVKVKENRRVTPADYDRYIFHIEFDISGTGM
TYDIGEALGIHARNNESLVKEFLTFYGLNESDVVLVPNKDNHHLLETRTVLQAFVENL
DIFGKPPKRFYESLIPYASNEEEKKKLEDLVTPAGAVDLKRFQDVEYYTYADIFELFP
SVRPSLEELVTIIEPLKRREYSIASSQKVHPNEVHLLIVVVDWVDNKGRKRYGQASKY
ISDLAVGSELVVSVKPSVMKLPPSPKQPVIMSGLGTGLAPFKAIVEEKLWQKQQGYEI
GEVFLYLGSRHKREEYLYGELWEAYKDAGIITHIGAAFSRDQPQKIYIQDRIKENLDE
LKTAMIDNKGSFYLCGPTWPVPDITQALQDILAKDAEERGIKVDLDAAIEELKEASRY
ILEVY"
rep_origin 216357..216704
/note="ARS608; Extremely inefficient autonomously
replicating sequence on Chr VI; activated early in S phase
in <10% of cell cycles"
/db_xref="SGD:S000007640"
gene complement(<216594..>220106)
/gene="SMC2"
/locus_tag="YFR031C"
/db_xref="GeneID:850589"
mRNA complement(<216594..>220106)
/gene="SMC2"
/locus_tag="YFR031C"
/product="condensin subunit SMC2"
/transcript_id="NM_001179996.2"
/db_xref="GeneID:850589"
CDS complement(216594..220106)
/gene="SMC2"
/locus_tag="YFR031C"
/experiment="EXISTENCE:direct assay:GO:0000217 DNA
secondary structure binding [PMID:9727028]"
/experiment="EXISTENCE:direct assay:GO:0000796 condensin
complex [PMID:10811823]"
/experiment="EXISTENCE:direct assay:GO:0003680 minor
groove of adenine-thymine-rich DNA binding [PMID:9727028]"
/experiment="EXISTENCE:direct assay:GO:0003682 chromatin
binding [PMID:16055730]"
/experiment="EXISTENCE:direct assay:GO:0003690
double-stranded DNA binding [PMID:9727028]"
/experiment="EXISTENCE:direct assay:GO:0005524 ATP binding
[PMID:9727028]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14576278|PMID:16823961]"
/experiment="EXISTENCE:direct assay:GO:0016887 ATP
hydrolysis activity [PMID:12719426]"
/experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic
sister chromatid segregation [PMID:10811823]"
/experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic
chromosome condensation [PMID:10811823]"
/experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA
gene clustering [PMID:18708579]"
/experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA
chromatin condensation [PMID:10811823]"
/experiment="EXISTENCE:mutant phenotype:GO:1903342
negative regulation of meiotic DNA double-strand break
formation [PMID:25103240]"
/note="Subunit of the condensin complex; condensin
reorganizes chromosomes during both mitosis and meiosis;
essential SMC chromosomal ATPase family member that forms
a subcomplex with Smc2p that has ATP-hydrolyzing and
DNA-binding activity, but other condensin subunits are
required for chromatin binding; required for clustering of
tRNA genes at the nucleolus"
/codon_start=1
/product="condensin subunit SMC2"
/protein_id="NP_116687.1"
/db_xref="GeneID:850589"
/db_xref="SGD:S000001927"
/translation="MKVEELIIDGFKSYATRTVITDWDPQFNAITGLNGSGKSNILDA
ICFVLGIASMSTVRASSLQDLIYKRGQAGVTKASVTIVFDNTDKSNSPIGFTNSPQIS
VTRQVVLGGTSKYLINGHRAPQQSVLQLFQSVQLNINNPNFLIMQGKITKVLNMKPSE
ILSLIEEAAGTKMFEDRREKAERTMSKKETKLQENRTLLTEEIEPKLEKLRNEKRMFL
EFQSTQTDLEKTERIVVSYEYYNIKHKHTSIRETLENGETRMKMLNEFVKKTSEEIDS
LNEDVEEIKLQKEKELHKEGTISKLENKENGLLNEISRLKTSLSIKVENLNDTTEKSK
ALESEIASSSAKLIEKKSAYANTEKDYKMVQEQLSKQRDLYKRKEELVSTLTTGISST
GAADGGYNAQLAKAKTELNEVSLAIKKSSMKMELLKKELLTIEPKLKEATKDNELNVK
HVKQCQETCDKLRARLVEYGFDPSRIKDLKQREDKLKSHYYQTCKNSEYLKRRVTNLE
FNYTKPYPNFEASFVHGVVGQLFQIDNDNIRYATALQTCAGGRLFNVVVQDSQTATQL
LERGRLRKRVTIIPLDKIYTRPISSQVLDLAKKIAPGKVELAINLIRFDESITKAMEF
IFGNSLICEDPETAKKITFHPKIRARSITLQGDVYDPEGTLSGGSRNTSESLLVDIQK
YNQIQKQIETIQADLNHVTEELQTQYATSQKTKTIQSDLNLSLHKLDLAKRNLDANPS
SQIIARNEEILRDIGECENEIKTKQMSLKKCQEEVSTIEKDMKEYDSDKGSKLNELKK
ELKLLAKELEEQESESERKYDLFQNLELETEQLSSELDSNKTLLHNHLKSIESLKLEN
SDLEGKIRGVEDDLVTVQTELNEEKKRLMDIDDELNELETLIKKKQDEKKSSELELQK
LVHDLNKYKSNTNNMEKIIEDLRQKHEFLEDFDLVRNIVKQNEGIDLDTYRERSKQLN
EKFQELRKKVNPNIMNMIENVEKKEAALKTMIKTIEKDKMKIQETISKLNEYKRETLV
KTWEKVTLDFGNIFADLLPNSFAKLVPCEGKDVTQGLEVKVKLGNIWKESLIELSGGQ
RSLIALSLIMALLQFRPAPMYILDEVDAALDLSHTQNIGHLIKTRFKGSQFIVVSLKE
GMFANANRVFRTRFQDGTSVVSIM"
gene complement(<220507..>221418)
/gene="RPL2A"
/locus_tag="YFR031C-A"
/gene_synonym="RPL5B"
/db_xref="GeneID:850590"
mRNA complement(join(<220507..221267,221415..>221418))
/gene="RPL2A"
/locus_tag="YFR031C-A"
/gene_synonym="RPL5B"
/product="ribosomal 60S subunit protein L2A"
/transcript_id="NM_001180030.3"
/db_xref="GeneID:850590"
CDS complement(join(220507..221267,221415..221418))
/gene="RPL2A"
/locus_tag="YFR031C-A"
/gene_synonym="RPL5B"
/experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic
translation [PMID:18782943]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:18782943]"
/experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
large ribosomal subunit [PMID:18782943]"
/experiment="EXISTENCE:mutant phenotype:GO:0042273
ribosomal large subunit biogenesis [PMID:18263608]"
/experiment="EXISTENCE:mutant phenotype:GO:1990145
maintenance of translational fidelity [PMID:18263608]"
/note="Ribosomal 60S subunit protein L2A; homologous to
mammalian ribosomal protein L2 and bacterial L2; RPL2A has
a paralog, RPL2B, that arose from the whole genome
duplication"
/codon_start=1
/product="ribosomal 60S subunit protein L2A"
/protein_id="NP_116688.3"
/db_xref="GeneID:850590"
/db_xref="SGD:S000002104"
/translation="MGRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGI
VKQIVHDSGRGAPLAKVVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNVL
PLGSVPEGTIVSNVEEKPGDRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISS
DARGVIGVIAGGGRVDKPLLKAGRAFHKYRLKRNSWPKTRGVAMNPVDHPHGGGNHQH
IGKASTISRGAVSGQKAGLIAARRTGLLRGSQKTQD"
gene 221714..221967
/gene="RUF23"
/locus_tag="YNCF0013W"
/db_xref="GeneID:9164890"
ncRNA 221714..221967
/ncRNA_class="other"
/gene="RUF23"
/locus_tag="YNCF0013W"
/product="RUF23"
/note="RNA of Unknown Function; precise location of 3' end
uncertain; RUF23 may be longer than currently annotated"
/transcript_id="NR_132175.1"
/db_xref="GeneID:9164890"
/db_xref="SGD:S000130133"
gene complement(<222090..>222959)
/gene="RRT5"
/locus_tag="YFR032C"
/db_xref="GeneID:850591"
mRNA complement(<222090..>222959)
/gene="RRT5"
/locus_tag="YFR032C"
/product="Rrt5p"
/transcript_id="NM_001179997.1"
/db_xref="GeneID:850591"
CDS complement(222090..222959)
/gene="RRT5"
/locus_tag="YFR032C"
/experiment="EXISTENCE:direct assay:GO:0005628 prospore
membrane [PMID:24390141]"
/note="hypothetical protein; non-essential gene identified
in a screen for mutants with increased levels of rDNA
transcription; expressed at high levels during
sporulation"
/codon_start=1
/product="Rrt5p"
/protein_id="NP_116689.1"
/db_xref="GeneID:850591"
/db_xref="SGD:S000001928"
/translation="MTEQVNNDTTSDTTTTITTVYISNLPFTASERDLHAFLNNYGAS
SVLIPTQTVRRFSKRHNSNPRKPLGIAFAQFANNTLALKAIQDLNGTVFQNQKLFLKL
HVPYEADSTPDTDVKKPKEKNKVKKTPETAADTVYCHDLPDDITDSEIRELFQLYSPQ
EIWIYRSKVYRRKCIPFAPHQITAALVTLQSETPIGDICDSVAKTATLRGKSIIVKPA
YVSKIQEIKQLVKDNLTNARDPPPAALAEPAPAPAPVEPAEQVQEGQDNAETNDVPPP
PASSSDRPTVAAT"
gene complement(<223258..>223437)
/gene="RPL29"
/locus_tag="YFR032C-A"
/db_xref="GeneID:850592"
mRNA complement(<223258..>223437)
/gene="RPL29"
/locus_tag="YFR032C-A"
/product="ribosomal 60S subunit protein L29"
/transcript_id="NM_001184311.3"
/db_xref="GeneID:850592"
CDS complement(223258..223437)
/gene="RPL29"
/locus_tag="YFR032C-A"
/experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic
translation [PMID:18782943]"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:18782943]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
large ribosomal subunit [PMID:18782943]"
/note="Ribosomal 60S subunit protein L29; not essential
for translation, but required for proper joining of large
and small ribosomal subunits and for normal translation
rate; homologous to mammalian ribosomal protein L29, no
bacterial homolog"
/codon_start=1
/product="ribosomal 60S subunit protein L29"
/protein_id="NP_116690.3"
/db_xref="GeneID:850592"
/db_xref="SGD:S000006437"
/translation="MAKSKNHTAHNQTRKAHRNGIKKPKTYKYPSLKGVDPKFRRNHK
HALHGTAKALAAAKK"
gene complement(<223710..>223973)
/gene="MIN10"
/locus_tag="YFR032C-B"
/db_xref="GeneID:1466402"
mRNA complement(<223710..>223973)
/gene="MIN10"
/locus_tag="YFR032C-B"
/product="Min10p"
/transcript_id="NM_001184591.1"
/db_xref="GeneID:1466402"
CDS complement(223710..223973)
/gene="MIN10"
/locus_tag="YFR032C-B"
/note="Mitochondrial hypothetical protein; identified by
gene-trapping, microarray-based expression analysis, and
genome-wide homology searching"
/codon_start=1
/product="Min10p"
/protein_id="NP_878072.1"
/db_xref="GeneID:1466402"
/db_xref="SGD:S000028630"
/translation="MVASRARENQRYSQCRKSTIFPLGFAIISGYIQFQNISILHISR
FNPLFYNIFHSIFKNPGTTIQLESTLYYHEVPISPIGNAGSQI"
gene complement(<224326..>224769)
/gene="QCR6"
/locus_tag="YFR033C"
/gene_synonym="COR3; UCR6"
/db_xref="GeneID:850593"
mRNA complement(<224326..>224769)
/gene="QCR6"
/locus_tag="YFR033C"
/gene_synonym="COR3; UCR6"
/product="ubiquinol--cytochrome-c reductase subunit 6"
/transcript_id="NM_001179998.3"
/db_xref="GeneID:850593"
CDS complement(224326..224769)
/gene="QCR6"
/locus_tag="YFR033C"
/gene_synonym="COR3; UCR6"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion
[PMID:11914276|PMID:14576278|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005750
mitochondrial respiratory chain complex III
[PMID:10873857]"
/experiment="EXISTENCE:direct assay:GO:0005758
mitochondrial intermembrane space [PMID:22984289]"
/experiment="EXISTENCE:direct assay:GO:0034399 nuclear
periphery [PMID:25817432]"
/experiment="EXISTENCE:mutant phenotype:GO:0006122
mitochondrial electron transport, ubiquinol to cytochrome
c [PMID:8288589]"
/experiment="EXISTENCE:mutant phenotype:GO:0008121
ubiquinol-cytochrome-c reductase activity [PMID:8288589]"
/experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic
respiration [PMID:8288589]"
/note="Subunit 6 of the ubiquinol cytochrome-c reductase
complex; the complex, also known as the cytochrome bc(1)
complex or Complex III, is a component of the
mitochondrial inner membrane electron transport chain;
highly acidic protein; required for maturation of
cytochrome c1; may be loosely associated with the complex
since it is easily released into the intermembrane space"
/codon_start=1
/product="ubiquinol--cytochrome-c reductase subunit 6"
/protein_id="NP_116691.3"
/db_xref="GeneID:850593"
/db_xref="SGD:S000001929"
/translation="MGMLELVGEYWEQLKITVVPVVAAAEDDDNEQHEEKAAEGEEKE
EENGDEDEDEDEDEDDDDDDDEDEEEEEEVTDQLEDLREHFKNTEEGKALVHHYEECA
ERVKIQQQQPGYADLEHKEDCVEEFFHLQHYLDTATAPRLFDKLK"
gene complement(<225020..>225958)
/gene="PHO4"
/locus_tag="YFR034C"
/db_xref="GeneID:850594"
mRNA complement(<225020..>225958)
/gene="PHO4"
/locus_tag="YFR034C"
/product="phosphate-sensing transcription factor PHO4"
/transcript_id="NM_001179999.1"
/db_xref="GeneID:850594"
CDS complement(225020..225958)
/gene="PHO4"
/locus_tag="YFR034C"
/experiment="EXISTENCE:direct assay:GO:0000122 negative
regulation of transcription by RNA polymerase II
[PMID:18408055]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:10320381]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:10320381]"
/experiment="EXISTENCE:direct assay:GO:0016036 cellular
response to phosphate starvation [PMID:10320381]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding
[PMID:2183025|PMID:2664469|PMID:19111667|PMID:19158363]"
/experiment="EXISTENCE:genetic interaction:GO:0045937
positive regulation of phosphate metabolic process
[PMID:3915785]"
/experiment="EXISTENCE:genetic interaction:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:3915785]"
/experiment="EXISTENCE:mutant phenotype:GO:0003700
DNA-binding transcription factor activity [PMID:2183025]"
/experiment="EXISTENCE:mutant phenotype:GO:0006338
chromatin remodeling [PMID:2196175]"
/experiment="EXISTENCE:mutant phenotype:GO:0016036
cellular response to phosphate starvation [PMID:10320381]"
/experiment="EXISTENCE:mutant phenotype:GO:0045944
positive regulation of transcription by RNA polymerase II
[PMID:3139496|PMID:4616940]"
/note="Basic helix-loop-helix (bHLH) transcription factor
of the myc-family; activates transcription cooperatively
with Pho2p in response to phosphate limitation; binding to
'CACGTG' motif is regulated by chromatin restriction,
competitive binding of Cbf1p to the same DNA binding motif
and cooperation with Pho2p; function is regulated by
phosphorylation at multiple sites and by phosphate
availability"
/codon_start=1
/product="phosphate-sensing transcription factor PHO4"
/protein_id="NP_116692.1"
/db_xref="GeneID:850594"
/db_xref="SGD:S000001930"
/translation="MGRTTSEGIHGFVDDLEPKSSILDKVGDFITVNTKRHDGREDFN
EQNDELNSQENHNSSENGNENENEQDSLALDDLDRAFELVEGMDMDWMMPSHAHHSPA
TTATIKPRLLYSPLIHTQSAVPVTISPNLVATATSTTSANKVTKNKSNSSPYLNKRRG
KPGPDSATSLFELPDSVIPTPKPKPKPKQYPKVILPSNSTRRVSPVTAKTSSSAEGVV
VASESPVIAPHGSSHSRSLSKRRSSGALVDDDKRESHKHAEQARRNRLAVALHELASL
IPAEWKQQNVSAAPSKATTVEAACRYIRHLQQNVST"
gene complement(<226121..>226465)
/locus_tag="YFR035C"
/db_xref="GeneID:850595"
mRNA complement(<226121..>226465)
/locus_tag="YFR035C"
/product="uncharacterized protein"
/transcript_id="NM_001180000.3"
/db_xref="GeneID:850595"
CDS complement(226121..226465)
/locus_tag="YFR035C"
/note="hypothetical protein; deletion mutant exhibits
synthetic phenotype with alpha-synuclein"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116693.3"
/db_xref="GeneID:850595"
/db_xref="SGD:S000001931"
/translation="MSASDKTKLCNKGMSRTSRTTTFVITPAFRERDDEGANSLCKAF
LNTFSNLKSGMFKCLLGVGAVGTFISTFPQFFLLPCLLCVRCVCVCLCASISYAASAI
FSFSIFFFFCLA"
gene complement(226688..226760)
/locus_tag="YNCF0014C"
/db_xref="GeneID:850596"
tRNA complement(226688..226760)
/locus_tag="YNCF0014C"
/product="tRNA-Lys"
/experiment="EXISTENCE:curator inference:GO:0006414
translational elongation [PMID:9023104]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:8915539]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:8915539]"
/experiment="EXISTENCE:mutant phenotype:GO:0030533 triplet
codon-amino acid adaptor activity [PMID:17560369]"
/experiment="EXISTENCE:mutant phenotype:GO:0032543
mitochondrial translation [PMID:17560369]"
/note="Lysine tRNA (tRNA-Lys), predicted by tRNAscan-SE
analysis; a small portion is imported into mitochondria
via interaction with mt lysyl-tRNA synthetase Msk1p and is
necessary to decode AAG codons at high temperature, when
base modification of mt-encoded tRNA-Lys is reduced"
/db_xref="GeneID:850596"
/db_xref="SGD:S000006620"
gene <226963..>227337
/gene="CDC26"
/locus_tag="YFR036W"
/gene_synonym="HIT3; SCD26"
/db_xref="GeneID:850597"
mRNA <226963..>227337
/gene="CDC26"
/locus_tag="YFR036W"
/gene_synonym="HIT3; SCD26"
/product="anaphase promoting complex subunit CDC26"
/transcript_id="NM_001180001.1"
/db_xref="GeneID:850597"
CDS 226963..227337
/gene="CDC26"
/locus_tag="YFR036W"
/gene_synonym="HIT3; SCD26"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0005680
anaphase-promoting complex [PMID:9469814]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:22932476]"
/experiment="EXISTENCE:direct assay:GO:0031145
anaphase-promoting complex-dependent catabolic process
[PMID:8895471]"
/experiment="EXISTENCE:genetic interaction:GO:0006325
chromatin organization [PMID:12399376]"
/experiment="EXISTENCE:mutant phenotype:GO:0016567 protein
ubiquitination [PMID:8895471]"
/experiment="EXISTENCE:mutant phenotype:GO:0061630
ubiquitin protein ligase activity [PMID:8895471]"
/note="Subunit of the Anaphase-Promoting Complex/Cyclosome
(APC/C); which is a ubiquitin-protein ligase required for
degradation of anaphase inhibitors, including mitotic
cyclins, during the metaphase/anaphase transition;
relocalizes to the cytosol in response to hypoxia"
/codon_start=1
/product="anaphase promoting complex subunit CDC26"
/protein_id="NP_116694.1"
/db_xref="GeneID:850597"
/db_xref="SGD:S000001932"
/translation="MIRRAPTTLQLSHDDVTSLIDDLNEQKLKQQLNIEKTKYFQGKN
GGSLHSNTDFQDTSQNIEDNNNDNDNDIDEDDDMSSYNDKAASVAHTRVLNSLHLSTD
SNTAHETSNANDNHNPFYIREE"
gene complement(<227513..>229186)
/gene="RSC8"
/locus_tag="YFR037C"
/gene_synonym="SWH3"
/db_xref="GeneID:850598"
mRNA complement(<227513..>229186)
/gene="RSC8"
/locus_tag="YFR037C"
/gene_synonym="SWH3"
/product="Rsc8p"
/transcript_id="NM_001180002.3"
/db_xref="GeneID:850598"
CDS complement(227513..229186)
/gene="RSC8"
/locus_tag="YFR037C"
/gene_synonym="SWH3"
/experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
[PMID:16461455]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0006303
double-strand break repair via nonhomologous end joining
[PMID:15870268]"
/experiment="EXISTENCE:direct assay:GO:0006337 nucleosome
disassembly [PMID:16492771]"
/experiment="EXISTENCE:direct assay:GO:0006368
transcription elongation by RNA polymerase II
[PMID:17081996]"
/experiment="EXISTENCE:direct assay:GO:0016586 RSC-type
complex [PMID:10619019|PMID:12183366]"
/experiment="EXISTENCE:mutant phenotype:GO:0006303
double-strand break repair via nonhomologous end joining
[PMID:15870268]"
/note="Component of the RSC chromatin remodeling complex;
essential for viability and mitotic growth; homolog of
SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate
transcription of reporters"
/codon_start=1
/product="Rsc8p"
/protein_id="NP_116695.3"
/db_xref="GeneID:850598"
/db_xref="SGD:S000001933"
/translation="MSDTEKDKDVPMVDSHEATEEPPTTSTNTPSFPHLAQEQAKEES
ATLGAEVAHKKINYEQEAQKLEEKALRFLAKQTHPVIIPSFASWFDISKIHEIEKRSN
PDFFNDSSRFKTPKAYKDTRNFIINTYRLSPYEYLTITAVRRNVAMDVASIVKIHAFL
EKWGLINYQIDPRTKPSLIGPSFTGHFQVVLDTPQGLKPFLPENVIKQEVEGGDGAEP
QVKKEFPVNLTIKKNVYDSAQDFNALQDESRNSRQIHKVYICHTCGNESINVRYHNLR
ARDTNLCSRCFQEGHFGANFQSSDFIRLENNGNSVKKNWSDQEMLLLLEGIEMYEDQW
EKIADHVGGHKRVEDCIEKFLSLPIEDNYIREVVGSTLNGKGGDSRDGSVSGSKLMEC
VNDAVQTLLQGDDKLGKVSDKSREISEKYIEESQAIIQELVKLTMEKLESKFTKLCDL
ETQLEMEKLKYVKESEKMLNDRLSLSKQILDLNKSLEELNVSKKLVLISEQVDSGIQL
VEKDQEGDDEDGNTATGHGVKRVGKEGEEVGEGDSIAKLQPQVYKPWSL"
gene <229380..>231941
/gene="IRC5"
/locus_tag="YFR038W"
/db_xref="GeneID:850599"
mRNA <229380..>231941
/gene="IRC5"
/locus_tag="YFR038W"
/product="putative ATPase"
/transcript_id="NM_001180003.1"
/db_xref="GeneID:850599"
CDS 229380..231941
/gene="IRC5"
/locus_tag="YFR038W"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic
recombination [PMID:18085829]"
/experiment="EXISTENCE:mutant phenotype:GO:0070987
error-free translesion synthesis [PMID:30111537]"
/note="Putative ATPase containing the DEAD/H
helicase-related sequence motif; null mutant displays
increased levels of spontaneous Rad52p foci; SWAT-GFP and
mCherry fusion proteins localize to the nucleus"
/codon_start=1
/product="putative ATPase"
/protein_id="NP_116696.2"
/db_xref="GeneID:850599"
/db_xref="SGD:S000001934"
/translation="MSRCSNAALMTVVEDAVGARVAARTRNMSNGVNYREKEVNDLTA
DISDSDSDLDSEDNKHGKGDNDTAPIWLQDDVHSDEDIQLDSEDDSDTEAVQAQVVDK
LAKDTKSEQKSLDDELSEMDTKTVSLKLKKLNEFVRQSQVYSSIIADTLLHRSNEVAN
ANTKDNSNSDDEEHSSKKRKTKKKSITDFFKKQKKNEDTTTQNGAPDDAAIKQPRLLK
NCILKPYQLEGLNWLITLYENGLNGILADEMGLGKTVQSIALLAFIYEMDTKGPFLVT
APLSTLDNWMNEFAKFAPDLPVLKYYGTNGYKERSAKLKNFFKQHGGTGIVITSYEII
LRDTDLIMSQNWKFLIVDEGHRLKNINCRLIKELKKINTSNRLLLTGTPLQNNLAELW
SLLNFIMPDIFADFEIFNKWFDFDSLNLGSGSNSEALNKLINDELQKNLISNLHTILK
PFLLRRLKKVVLANILPPKREYIINCPMTSAQEKFYKAGLNGKLKKTMFKELIKDFFT
LNDEYIGHVSNRSIRDFINYKLSGNETSNTDNKINPTLLQMDKLYKKNLQMEISNKKL
QNMMMQLRQIIDSTFLFYFPYLHPEDLTLETLLKTSGKLQILQKLIPPLISEGHKVLI
YSQFVNMLDLIEDWCDLNSFATFRIDGSVNNETRKDQLEKFNSSKDKHNIFLLSTRAA
GLGINLVGADTVVLFDSDWNPQVDLQAMDRCHRIGQESPVIVYRLCCDNTIEHVILTR
AANKRNLERMVIQMGKFNNLKKLALNEGSFLKANKAGVNVTNKDLVQELSMLLMSDES
NIGFENGGQKENKATEGQLTDKEVEELTNRSLEAYKANRVVDLPHVKLFETTSGL"
gene complement(<232012..>233544)
/gene="OSW7"
/locus_tag="YFR039C"
/db_xref="GeneID:850600"
mRNA complement(<232012..>233544)
/gene="OSW7"
/locus_tag="YFR039C"
/product="Osw7p"
/transcript_id="NM_001180004.3"
/db_xref="GeneID:850600"
CDS complement(232012..233544)
/gene="OSW7"
/locus_tag="YFR039C"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:genetic interaction:GO:0030476
ascospore wall assembly [PMID:23966878]"
/note="Protein involved in outer spore wall assembly;
likely involved directly in dityrosine layer assembly; may
be involved in response to high salt and changes in carbon
source; SWAT-GFP, seamless-GFP and mCherry fusion proteins
localize to the endoplasmic reticulum; deletion mutant has
decreased spore survival in Drosophila feces; OSW7 has a
paralog, SHE10, that arose from the whole genome
duplication; paralogs are redundant for spore wall
dityrosine assembly"
/codon_start=1
/product="Osw7p"
/protein_id="NP_116697.3"
/db_xref="GeneID:850600"
/db_xref="SGD:S000001935"
/translation="MKAVFKVTTALLACVFIARYLVCQQNGLGSFATDLQPICRHTEF
SVGSLFDSKLVEGSAVSDYLVGKYSQSIKPLIERYPNSSLKRIMGYFYRFWYNIFSFL
RLNELCCSLHSKLGPLLNHLRIAWYYLKPYTDNVKNVLENPFNSSTDWMKYGSFSADG
TLTKPIFETDSETEDYEDDENENEDEDEDEDEDDVGIEDENKEYEFDGVQDGHGNSQL
VTAAILQDLSKIIIGSNSHAELETYEAESLKMEYEAWIKAIDSKIHSAMALLDSEIQS
VFEAEVQNKSIEITRNLDDLNTTVNEQLVFLDSKIKDINCTSKFDPVQNKIKYFDESG
QVELEAYITKSSITSILKNYKIHLLDFEKSLFHSLDSFLTEMAKLAESIRLENVEVYE
EWGDVMISQWSQRMAYMDVRGLHLEDQYDPAYIEENHSNWLRFMELKKKVISERNRLV
KHDLDMTLILEWITKLKADFQNTKNNIQDTFLQRMNTADTLFKNRELKEQLEEEFVRQ
EH"
gene <234242..>237250
/gene="SAP155"
/locus_tag="YFR040W"
/db_xref="GeneID:850601"
mRNA <234242..>237250
/gene="SAP155"
/locus_tag="YFR040W"
/product="Sap155p"
/transcript_id="NM_001180005.2"
/db_xref="GeneID:850601"
CDS 234242..237250
/gene="SAP155"
/locus_tag="YFR040W"
/experiment="EXISTENCE:direct assay:GO:1903765 negative
regulation of potassium ion export across plasma membrane
[PMID:15947196]"
/experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S
transition of mitotic cell cycle [PMID:8649382]"
/experiment="EXISTENCE:mutant phenotype:GO:1903765
negative regulation of potassium ion export across plasma
membrane [PMID:15947196]"
/note="Protein required for function of the Sit4p protein
phosphatase; forms a complex with Sit4p; member of a
family of similar proteins including Sap4p, Sap185p, and
Sap190p; protein abundance increases in response to DNA
replication stress; SAP155 has a paralog, SAP4, that arose
from the whole genome duplication"
/codon_start=1
/product="Sap155p"
/protein_id="NP_116698.3"
/db_xref="GeneID:850601"
/db_xref="SGD:S000001936"
/translation="MSFWPFGQNLNHSNINKILDEYFHVLHELERINPSVGKAIPAIF
NNVQERGTSDSLDSIPEEYSHGDEVKTARGDQKSRFEKDDQQERYEKEEEERSMNSSE
SSTTSFSSGSTSKTDLDEEDISNATAPMMVTTKNLDNSFIERMLVETELLNELSRQNK
TLLDFICFGFFFDKKTNKKVNNMEYLVDQLMECISKIKTATTVDLNNLIDYQEQQQLD
DSSQEDVYVESDTEQEEEKEDDNNSNNKKRRKRGSSSFGNDDINNNDDDDDANEDDES
AYLTKATIISEIFSLDIWLISESLVKNQSYLNKIWSIINQPNFNSENSPLVPIFLKIN
QNLLLTRQDQYLNFIRTERSFVDDMLKHVDISLLMDFFLKIISTDKIESPTGIIELVY
DQNLISKCLSFLNNKESPADIQACVGDFLKALIAISANAPLDDISIGPNSLTRQLASP
ESIAKLVDIMINQRGAALNTTVSIVIELIRKNNSDYDQVNLLTTTIKTHPPSNRDPIY
LGYLLRKFSNHLSDFFQIILDIENDANIPLHENQLHEKFKPLGFERFKVVELIAELLH
CSNMGLMNSKRAERIARRRDKVRSQLSHHLQDALNDLSIEEKEQLKTKHSPTRDTDHD
LKNNNGKIDNDNNDNDDESDYGDEIDESFEIPYINMKQNIKLRTDPTVGDLFKIKLYD
TRIVSKIMELFLTHPWNNFWHNVIFDIIQQIFNGRMDFSYNSFLVLSLFNLKSSYQFM
TDIVISDEKGTDVSRFSPVIRDPNFDFKITTDFILRGYQDSYKFYELRKMNLGYMGHI
VLIAEEVVKFSKLYKVELISPDIQVILQTEEWQYYSEEVLNETRMMYSKILGGGSYID
DGNGNIIPQLPDNTTVLTPNGDASNNNEILDSDTGSSNGTSGGGQLINVESLEEQLSL
STESDLHNKLREMLINRAQEDVDNKNTENGVFILGPPEDKNSNSNINNTNHNSNNSNN
NDNNDNNDNDNDNTRNYNEDADNDNDYDHE"
gene complement(<237368..>238255)
/gene="ERJ5"
/locus_tag="YFR041C"
/db_xref="GeneID:850602"
mRNA complement(<237368..>238255)
/gene="ERJ5"
/locus_tag="YFR041C"
/product="Erj5p"
/transcript_id="NM_001180006.3"
/db_xref="GeneID:850602"
CDS complement(237368..238255)
/gene="ERJ5"
/locus_tag="YFR041C"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:14562095|PMID:17157937|PMID:26928762]"
/experiment="EXISTENCE:mutant phenotype:GO:0006457 protein
folding [PMID:17157937]"
/note="Type I membrane protein with a J domain; required
to preserve the folding capacity of the endoplasmic
reticulum; loss of the non-essential ERJ5 gene leads to a
constitutively induced unfolded protein response"
/codon_start=1
/product="Erj5p"
/protein_id="NP_116699.3"
/db_xref="GeneID:850602"
/db_xref="SGD:S000001937"
/translation="MNGYWKPALVVLGLVSLSYAFTTIETEIFQLQNEISTKYGPDMN
FYKFLKLPKLQNSSTKEITKNLRKLSKKYHPDKNPKYRKLYERLNLATQILSNSSNRK
IYDYYLQNGFPNYDFHKGGFYFSRMKPKTWFLLAFIWIVVNIGQYIISIIQYRSQRSR
IENFISQCKQQDDTNGLGVKQLTFKQHEKDEGKSLVVRFSDVYVVEPDGSETLISPDT
LDKPSVKNCLFWRIPASVWNMTFGKSVGSAGKEEIITDSKKYDGNQTKKGNKVKKGSA
KKGQKKMELPNGKVIYSRK"
gene <238458..>239060
/gene="KEG1"
/locus_tag="YFR042W"
/db_xref="GeneID:850603"
mRNA <238458..>239060
/gene="KEG1"
/locus_tag="YFR042W"
/product="Keg1p"
/transcript_id="NM_001180007.1"
/db_xref="GeneID:850603"
CDS 238458..239060
/gene="KEG1"
/locus_tag="YFR042W"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
reticulum membrane [PMID:17893149]"
/experiment="EXISTENCE:mutant phenotype:GO:0006078
(1->6)-beta-D-glucan biosynthetic process [PMID:17893149]"
/experiment="EXISTENCE:mutant phenotype:GO:0051276
chromosome organization [PMID:18439903]"
/note="Integral membrane protein of the ER; physically
interacts with Kre6p; has a role in the synthesis of
beta-1,6-glucan in the cell wall; required for cell
viability"
/codon_start=1
/product="Keg1p"
/protein_id="NP_116700.1"
/db_xref="GeneID:850603"
/db_xref="SGD:S000001938"
/translation="MAGIKLTHKLYQYYQLATSFLYAALLIRWLILMPLVGSRFLPGG
IHEFLIYLMFYSSIMEVIWLLRFHGFKYGLLSRTFLKDLNFIYLVSVIHFYDDYEHAL
ILKNASYSSFIISLSLSQAYCHWCKLFKRKGVKERTLVWKVNTFVTLPILYLSEFALL
LLNIQVKNYHSTPTLDIINRVVLLAYFPVLLTAYKKLLTK"
gene complement(<239114..>239827)
/gene="IRC6"
/locus_tag="YFR043C"
/db_xref="GeneID:850604"
mRNA complement(<239114..>239827)
/gene="IRC6"
/locus_tag="YFR043C"
/product="Irc6p"
/transcript_id="NM_001180008.3"
/db_xref="GeneID:850604"
CDS complement(239114..239827)
/gene="IRC6"
/locus_tag="YFR043C"
/experiment="EXISTENCE:direct assay:GO:0030674
protein-macromolecule adaptor activity [PMID:22993212]"
/experiment="EXISTENCE:genetic interaction:GO:0016192
vesicle-mediated transport [PMID:22993212]"
/experiment="EXISTENCE:physical interaction:GO:0016192
vesicle-mediated transport [PMID:22993212]"
/note="Clathrin coat accessory factor; involved in
clathrin-mediated vesicle trafficking; may function to
link the AP-1 clathrin adaptor complex with the Rab GTPase
Ypt31p; has structural similarity to G-proteins; mouse
homolog Aagab (p34) functionally complements irc6 null
mutation; null mutant displays increased levels of
spontaneous Rad52p foci"
/codon_start=1
/product="Irc6p"
/protein_id="NP_116701.3"
/db_xref="GeneID:850604"
/db_xref="SGD:S000001939"
/translation="MVLQYPQNKILVLSDHPHNFLKTQFLQDLFHCSSTGISIVKDQT
WENRYYKVHFDLYIDSCKEIPVWVEEFITPECEPLRNVMAGIILITDIRQTKPQELLH
QFMIAAHRNTFVVLANVNEEVEQDEIDELNEIWSNAFTNVIEFVNWKRSKPTVNHNDY
GEKLGLDRIQEIIDTHDWLNCEVQPATKIREEIPNEMPLEQIIRNLQSARLKYKSIEN
SSEADAFANEMADELSRYL"
gene complement(<239992..>241437)
/gene="DUG1"
/locus_tag="YFR044C"
/db_xref="GeneID:850605"
mRNA complement(<239992..>241437)
/gene="DUG1"
/locus_tag="YFR044C"
/product="metallodipeptidase"
/transcript_id="NM_001180009.1"
/db_xref="GeneID:850605"
CDS complement(239992..241437)
/gene="DUG1"
/locus_tag="YFR044C"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276|PMID:14562095|PMID:17179087]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0070573
metallodipeptidase activity [PMID:19346245]"
/experiment="EXISTENCE:genetic interaction:GO:0008242
omega peptidase activity [PMID:17179087]"
/experiment="EXISTENCE:mutant phenotype:GO:0006751
glutathione catabolic process [PMID:17179087]"
/experiment="EXISTENCE:mutant phenotype:GO:0070573
metallodipeptidase activity [PMID:19346245]"
/note="Cys-Gly metallo-di-peptidase; forms a complex with
Dug2p and Dug3p to degrade glutathione (GSH) and other
peptides containing a gamma-glu-X bond in an alternative
pathway to GSH degradation by gamma-glutamyl
transpeptidase (Ecm38p); human homolog CNDP2 can
complement yeast dug1 mutant"
/codon_start=1
/product="metallodipeptidase"
/protein_id="NP_116702.1"
/db_xref="GeneID:850605"
/db_xref="SGD:S000001940"
/translation="MSHSLTSVFQKIDSLKPQFFSRLTKAIQIPAVSSDESLRSKVFD
KAKFISEQLSQSGFHDIKMVDLGIQPPPISTPNLSLPPVILSRFGSDPSKKTVLVYGH
YDVQPAQLEDGWDTEPFKLVIDEAKGIMKGRGVTDDTGPLLSWINVVDAFKASGQEFP
VNLVTCFEGMEESGSLKLDELIKKEANGYFKGVDAVCISDNYWLGTKKPVLTYGLRGC
NYYQTIIEGPSADLHSGIFGGVVAEPMIDLMQVLGSLVDSKGKILIDGIDEMVAPLTE
KEKALYKDIEFSVEELNAATGSKTSLYDKKEDILMHRWRYPSLSIHGVEGAFSAQGAK
TVIPAKVFGKFSIRTVPDMDSEKLTSLVQKHCDAKFKSLNSPNKCRTELIHDGAYWVS
DPFNAQFTAAKKATKLVYGVDPDFTREGGSIPITLTFQDALNTSVLLLPMGRGDDGAH
SINEKLDISNFVGGMKTMAAYLQYYSESPEN"
gene <241998..>242999
/gene="MRX20"
/locus_tag="YFR045W"
/db_xref="GeneID:850606"
mRNA join(<241998..242009,242082..>242999)
/gene="MRX20"
/locus_tag="YFR045W"
/product="Mrx20p"
/transcript_id="NM_001180010.3"
/db_xref="GeneID:850606"
CDS join(241998..242009,242082..242999)
/gene="MRX20"
/locus_tag="YFR045W"
/note="Putative mitochondrial transport protein; null
mutant is viable, exhibits decreased levels of chitin and
normal resistance to calcofluor white"
/codon_start=1
/product="Mrx20p"
/protein_id="NP_116703.5"
/db_xref="GeneID:850606"
/db_xref="SGD:S000001941"
/translation="MANQNSDLYKQITAGSVAAVFQTTMTYPFEYLKTGLQLQPKGTA
FEIILPQIKSYFVGCSALNVAAFGKTILRFVTFDKLCHSLNNNIDNNDNFQRLTGYNL
LIAGTLTGIVESLFIIPFENIKTTLIQSAMIDHKKLEKNQPVVNAKATFHKVATKSTP
VARIEKLLPAVKHMYQTRGPAAFVQGTTATIFRQIANTSIQFTAYTAFKRLLQARNDK
ASSVITGLATSFTLVAMTQPIDVVKTRMMSQNAKTEYKNTLNCMYRIFVQEGMATFWK
GSIFRFMKVGISGGLTFTVYEQVSLLLGFSSRS"
gene complement(<243074..>244159)
/gene="CNN1"
/locus_tag="YFR046C"
/db_xref="GeneID:850607"
mRNA complement(<243074..>244159)
/gene="CNN1"
/locus_tag="YFR046C"
/product="centromere-binding protein CNN1"
/transcript_id="NM_001180011.1"
/db_xref="GeneID:850607"
CDS complement(243074..244159)
/gene="CNN1"
/locus_tag="YFR046C"
/experiment="EXISTENCE:direct assay:GO:0000776 kinetochore
[PMID:14633972]"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0019237 centromeric
DNA binding [PMID:22561345|PMID:22561346]"
/experiment="EXISTENCE:direct assay:GO:0044877
protein-containing complex binding
[PMID:22561345|PMID:22561346]"
/experiment="EXISTENCE:mutant phenotype:GO:1905560
negative regulation of kinetochore assembly
[PMID:22561345]"
/experiment="EXISTENCE:physical interaction:GO:0007059
chromosome segregation [PMID:14633972|PMID:9520439]"
/note="Kinetochore protein; associated with the essential
kinetochore proteins Nnf1p and Spc24p; phosphorylated by
Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by
Clb2-Cdk1; localizes to the lower region of the Ndc80
complex during anaphase and regulates KMN activity by
inhibiting the Mtw1 and Spc105 complexes from binding to
the Ndc80 complex; similar to metazoan CENP-T"
/codon_start=1
/product="centromere-binding protein CNN1"
/protein_id="NP_116704.1"
/db_xref="GeneID:850607"
/db_xref="SGD:S000001942"
/translation="MSTPRKAAGNNENTEVSEIRTPFRERALEEQRLKDEVLIRNTPG
YRKLLSASTKSHDILNKDPNEVRSFLQDLSQVLARKSQGNDTTTNKTQARNLIDELAY
EESQPEENELLRSRSEKLTDNNIGNETQPDYTSLSQTVFAKLQERDKGLKSRKIDPII
IQDVPTTGHEDELTVHSPDKANSISMEVLRTSPSIGMDQVDEPPVRDPVPISITQQEE
PLSEDLPSDDKEETEEAENEDYSFENTSDENLDDIGNDPIRLNVPAVRRSSIKPLQIM
DLKHLTRQFLNENRIILPKQTWSTIQEESLNIMDFLKQKIGTLQKQELVDSFIDMGII
NNVDDMFELAHELLPLELQSRIESYLF"
gene complement(<244279..>245166)
/gene="BNA6"
/locus_tag="YFR047C"
/gene_synonym="QPT1"
/db_xref="GeneID:850608"
mRNA complement(<244279..>245166)
/gene="BNA6"
/locus_tag="YFR047C"
/gene_synonym="QPT1"
/product="nicotinate-nucleotide diphosphorylase
(carboxylating)"
/transcript_id="NM_001180012.3"
/db_xref="GeneID:850608"
CDS complement(244279..245166)
/gene="BNA6"
/locus_tag="YFR047C"
/gene_synonym="QPT1"
/EC_number="2.4.2.19"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:14562095]"
/experiment="EXISTENCE:genetic interaction:GO:0034354 'de
novo' NAD biosynthetic process from tryptophan
[PMID:12062417]"
/experiment="EXISTENCE:mutant phenotype:GO:0004514
nicotinate-nucleotide diphosphorylase (carboxylating)
activity [PMID:12062417]"
/note="Quinolinate phosphoribosyl transferase; required
for the de novo biosynthesis of NAD from tryptophan via
kynurenine; expression regulated by Hst1p"
/codon_start=1
/product="nicotinate-nucleotide diphosphorylase
(carboxylating)"
/protein_id="NP_602317.3"
/db_xref="GeneID:850608"
/db_xref="SGD:S000001943"
/translation="MPVYEHLLPVNGAWRQDVTNWLSEDVPSFDFGGYVVGSDLKEAN
LYCKQDGMLCGVPFAQEVFNQCELQVEWLFKEGSFLEPSKNDSGKIVVAKITGPAKNI
LLAERTALNILSRSSGIATASHKIISLARSTGYKGTIAGTRKTTPGLRRLEKYSMLVG
GCDTHRYDLSSMVMLKDNHIWATGSITNAVKNARAVCGFAVKIEVECLSEDEATEAIE
AGADVIMLDNFKGDGLKMCAQSLKNKWNGKKHFLLECSGGLNLDNLEEYLCDDIDIYS
TSSIHQGTPVIDFSLKLAH"
gene <246146..>248134
/gene="RMD8"
/locus_tag="YFR048W"
/db_xref="GeneID:850609"
mRNA <246146..>248134
/gene="RMD8"
/locus_tag="YFR048W"
/product="Rmd8p"
/transcript_id="NM_001180013.1"
/db_xref="GeneID:850609"
CDS 246146..248134
/gene="RMD8"
/locus_tag="YFR048W"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11914276]"
/experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
reticulum [PMID:26928762]"
/note="Cytosolic protein required for sporulation"
/codon_start=1
/product="Rmd8p"
/protein_id="NP_683716.1"
/db_xref="GeneID:850609"
/db_xref="SGD:S000001944"
/translation="MSYKANQPSPGEMPKRSPSILVTDARTSKNRMSAPFAGHAAGSR
KNMENAGVTKSQGVRSSAIGPSPLQSFTHPRRRSSGRFSDISIDNILSDNSDIPSARR
EERLSSSSSDRPRQYERLSSRRKMINPLPPRTSKTSQKLVLIPEDDNLNHFQTLPTNA
LDRQRPKVGSMKSNSFDRLPRYSKEKSMARITAYNVADGFNLNQLYKFLQETHEVSPR
LYDECLYVAYTLPLLPGKGGFRIKSNLSKKTMGGKTLIDNLIDTSEQRDHHYEYYSGV
ETVEDANNNYELETSGNNNNANQDTTTVPDHLPNPVGQQDSFNPMEPQFFAEETPLEI
EKRERTERINMLKKEENDSDASCGNDNNNKNNDKSKLYAVEGNDQYVQSSRSPASPSS
ISTPSPPSSSQNDFDRVYKMHRDNDHEGNDRHAEIFIFHYGVIVFWNFTEIQEKNILG
DITFADYKNLMIRPLDEQDIETEQFHFEYDRDTERPRIFNDIVTLRSGDHIIELTLSH
AIAQSSKLSRFESRISPILISVTKLPKRLALYGTLGLKREQLLKKSGKLFKLRVDVNL
SSTILDTPEFFWSFEPSLHPLYVAMREYLEIDQRVQVLNDRCKVFLEFFDICVDSVAE
RNMARVTWWFILVILFGVIFSLTEIFVRYVIIHRHTST"
gene <248523..>248894
/gene="YMR31"
/locus_tag="YFR049W"
/gene_synonym="KGD4"
/db_xref="GeneID:850610"
mRNA <248523..>248894
/gene="YMR31"
/locus_tag="YFR049W"
/gene_synonym="KGD4"
/product="mitochondrial 37S ribosomal protein YMR31"
/transcript_id="NM_001180014.3"
/db_xref="GeneID:850610"
CDS 248523..248894
/gene="YMR31"
/locus_tag="YFR049W"
/gene_synonym="KGD4"
/experiment="EXISTENCE:direct assay:GO:0003735 structural
constituent of ribosome [PMID:2693936]"
/experiment="EXISTENCE:direct assay:GO:0004591
oxoglutarate dehydrogenase (succinyl-transferring)
activity [PMID:25165143]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16823961|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005761
mitochondrial ribosome [PMID:2693936]"
/experiment="EXISTENCE:direct assay:GO:0009353
mitochondrial oxoglutarate dehydrogenase complex
[PMID:25165143]"
/experiment="EXISTENCE:mutant phenotype:GO:0004591
oxoglutarate dehydrogenase (succinyl-transferring)
activity [PMID:25165143]"
/experiment="EXISTENCE:mutant phenotype:GO:0006099
tricarboxylic acid cycle [PMID:25165143]"
/experiment="EXISTENCE:mutant phenotype:GO:0006103
2-oxoglutarate metabolic process [PMID:25165143]"
/note="Subunit of the mitochondrial alpha-ketoglutarate
dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2
(Kgd1p, Kgd2p) core; exists in two forms derived from a
single mRNA translated from two alternative start sites;
has similarity to human mitochondrial ribosomal protein
MRP-S36"
/codon_start=1
/product="mitochondrial 37S ribosomal protein YMR31"
/protein_id="NP_116707.3"
/db_xref="GeneID:850610"
/db_xref="SGD:S000001945"
/translation="MIATPIRLAKSAYEPMIKFVGTRHPLVKHATEVVVHPCATNGML
PGSKECIPVSKFMENYKPFRVVPIKHSANAGLSSSKTSVFVNRPLQKDELASIFELPA
RFRYKPINEHELESINSGGAW"
gene complement(<249066..>249866)
/gene="PRE4"
/locus_tag="YFR050C"
/db_xref="GeneID:850611"
mRNA complement(<249066..>249866)
/gene="PRE4"
/locus_tag="YFR050C"
/product="proteasome core particle subunit beta 7"
/transcript_id="NM_001180015.1"
/db_xref="GeneID:850611"
CDS complement(249066..249866)
/gene="PRE4"
/locus_tag="YFR050C"
/experiment="EXISTENCE:direct assay:GO:0005634 nucleus
[PMID:26928762]"
/experiment="EXISTENCE:direct assay:GO:0010499 proteasomal
ubiquitin-independent protein catabolic process
[PMID:19162040]"
/experiment="EXISTENCE:direct assay:GO:0019774 proteasome
core complex, beta-subunit complex [PMID:9087403]"
/experiment="EXISTENCE:direct assay:GO:0034515 proteasome
storage granule [PMID:18504300]"
/experiment="EXISTENCE:direct assay:GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic
process [PMID:11545745|PMID:19029916]"
/experiment="EXISTENCE:genetic interaction:GO:0043248
proteasome assembly [PMID:17911101]"
/note="Beta 7 subunit of the 20S proteasome"
/codon_start=1
/product="proteasome core particle subunit beta 7"
/protein_id="NP_116708.1"
/db_xref="GeneID:850611"
/db_xref="SGD:S000001946"
/translation="MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSV
ISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKD
LVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFL
RYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLY
YRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI"
gene complement(<250163..>251803)
/gene="RET2"
/locus_tag="YFR051C"
/db_xref="GeneID:850612"
mRNA complement(<250163..>251803)
/gene="RET2"
/locus_tag="YFR051C"
/product="coatomer subunit delta"
/transcript_id="NM_001180016.3"
/db_xref="GeneID:850612"
CDS complement(250163..251803)
/gene="RET2"
/locus_tag="YFR051C"
/experiment="EXISTENCE:direct assay:GO:0030126 COPI
vesicle coat [PMID:21435344]"
/experiment="EXISTENCE:genetic interaction:GO:0048313
Golgi inheritance [PMID:18595704]"
/experiment="EXISTENCE:genetic interaction:GO:0090167
Golgi distribution to daughter cells [PMID:18595704]"
/experiment="EXISTENCE:mutant phenotype:GO:0006888
endoplasmic reticulum to Golgi vesicle-mediated transport
[PMID:8617224]"
/experiment="EXISTENCE:mutant phenotype:GO:0006890
retrograde vesicle-mediated transport, Golgi to
endoplasmic reticulum [PMID:8617224]"
/experiment="EXISTENCE:mutant phenotype:GO:0030126 COPI
vesicle coat [PMID:8617224]"
/note="Delta subunit of the coatomer complex (COPI); COPI
coats Golgi-derived transport vesicles; involved in
retrograde transport between Golgi and ER"
/codon_start=1
/product="coatomer subunit delta"
/protein_id="NP_116709.3"
/db_xref="GeneID:850612"
/db_xref="SGD:S000001947"
/translation="MVVLAASITTRQGKPLLSRQFKDLSKDRVLELLSNFQNLVSEIS
SDHTFVEDKHVRYVYRPFDNYYIILITNRQSNIIKDLATLNLFSQTINSYLSSFQDQE
IFHNAFEILSSFDEIVSMGGYKENLSFTQVQTYLSMESHEERIQEIIERNKEIEATEE
RKRRAKEIARKEHERKHGFMSSNGDYDGANRFMGSKDPNVTNAINSYYSHASPAAQQS
YLQSSHAAAAEVAPVASPMATSQRAGHSATGGMKLGGGAGRRAGAAPRPSAISSASSG
TPPPPEEDVPENNGILISIKEVINAEFSRDGTIHSSELKGVLELRINDHDLSHSNLKL
ADSIDVRDKSFQFKTHPNIDKQSFLSTKLISLRDKSKAFPANDQSLGVLRWRKVAPAE
DDSLIPLTLTTWVSPSESQQGFDVIIEYESVLETELADVIFTIPVFPQEPVDINTESS
TCSDAEVVNMDQEMGTSIKISKIAANDAGALAFTIEAPYEDALYPMTVSFQESTRDKL
AKSFTGMAIQSVVMANDHDQELPYDVITSLKSDEYLVQ"
gene <252505..>253329
/gene="RPN12"
/locus_tag="YFR052W"
/gene_synonym="NIN1"
/db_xref="GeneID:850613"
mRNA <252505..>253329
/gene="RPN12"
/locus_tag="YFR052W"
/gene_synonym="NIN1"
/product="proteasome regulatory particle lid subunit
RPN12"
/transcript_id="NM_001180017.1"
/db_xref="GeneID:850613"
CDS 252505..253329
/gene="RPN12"
/locus_tag="YFR052W"
/gene_synonym="NIN1"
/experiment="EXISTENCE:direct assay:GO:0008541 proteasome
regulatory particle, lid subcomplex [PMID:9741626]"
/experiment="EXISTENCE:direct assay:GO:0034515 proteasome
storage granule [PMID:18504300]"
/experiment="EXISTENCE:mutant phenotype:GO:0006511
ubiquitin-dependent protein catabolic process
[PMID:10490625]"
/note="Subunit of the 19S regulatory particle of the 26S
proteasome lid; synthetically lethal with RPT1, which is
an ATPase component of the 19S regulatory particle;
physically interacts with Nob1p and Rpn3p; protein
abundance increases in response to DNA replication stress"
/codon_start=1
/product="proteasome regulatory particle lid subunit
RPN12"
/protein_id="NP_116710.1"
/db_xref="GeneID:850613"
/db_xref="SGD:S000001948"
/translation="MPSLAELTKSLSIAFENGDYAACEKLLPPIKIELIKNNLLIPDL
SIQNDIYLNDLMITKRILEVGALASIQTFNFDSFENYFNQLKPYYFSNNHKLSESDKK
SKLISLYLLNLLSQNNTTKFHSELQYLDKHIKNLEDDSLLSYPIKLDRWLMEGSYQKA
WDLLQSGSQNISEFDSFTDILKSAIRDEIAKNTELSYDFLPLSNIKALLFFNNEKETE
KFALERNWPIVNSKVYFNNQSKEKADYEDEMMHEEDQKTNIIEKAMDYAISIENIV"
gene complement(<253592..>255049)
/gene="HXK1"
/locus_tag="YFR053C"
/db_xref="GeneID:850614"
mRNA complement(<253592..>255049)
/gene="HXK1"
/locus_tag="YFR053C"
/product="hexokinase 1"
/transcript_id="NM_001180018.3"
/db_xref="GeneID:850614"
CDS complement(253592..255049)
/gene="HXK1"
/locus_tag="YFR053C"
/EC_number="2.7.1.1"
/experiment="EXISTENCE:direct assay:GO:0004396 hexokinase
activity [PMID:12611889|PMID:332086]"
/experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
[PMID:11254124]"
/experiment="EXISTENCE:direct assay:GO:0005739
mitochondrion [PMID:16962558|PMID:24769239]"
/experiment="EXISTENCE:direct assay:GO:0005829 cytosol
[PMID:14562095]"
/experiment="EXISTENCE:direct assay:GO:0006013 mannose
metabolic process [PMID:332086]"
/experiment="EXISTENCE:direct assay:GO:0006096 glycolytic
process [PMID:332086]"
/experiment="EXISTENCE:genetic interaction:GO:0046323
glucose import [PMID:6300872]"
/experiment="EXISTENCE:genetic interaction:GO:1990539
fructose import across plasma membrane [PMID:6300872]"
/experiment="EXISTENCE:mutant phenotype:GO:0004396
hexokinase activity [PMID:6341351]"
/experiment="EXISTENCE:mutant phenotype:GO:0006000
fructose metabolic process [PMID:6300872]"
/experiment="EXISTENCE:mutant phenotype:GO:0006006 glucose
metabolic process [PMID:6300872]"
/note="Hexokinase isoenzyme 1; a cytosolic protein that
catalyzes phosphorylation of glucose during glucose
metabolism; expression is highest during growth on
non-glucose carbon sources; glucose-induced repression
involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that
arose from the whole genome duplication"
/codon_start=1
/product="hexokinase 1"
/protein_id="NP_116711.3"
/db_xref="GeneID:850614"
/db_xref="SGD:S000001949"
/translation="MVHLGPKKPQARKGSMADVPKELMDEIHQLEDMFTVDSETLRKV
VKHFIDELNKGLTKKGGNIPMIPGWVMEFPTGKESGNYLAIDLGGTNLRVVLVKLSGN
HTFDTTQSKYKLPHDMRTTKHQEELWSFIADSLKDFMVEQELLNTKDTLPLGFTFSYP
ASQNKINEGILQRWTKGFDIPNVEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIA
SYYTDPETKMGVIFGTGVNGAFYDVVSDIEKLEGKLADDIPSNSPMAINCEYGSFDNE
HLVLPRTKYDVAVDEQSPRPGQQAFEKMTSGYYLGELLRLVLLELNEKGLMLKDQDLS
KLKQPYIMDTSYPARIEDDPFENLEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTRA
ARLAVCGIAAICQKRGYKTGHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPI
TIVPAEDGSGAGAAVIAALSEKRIAEGKSLGIIGA"
rep_origin 256277..256431
/note="ARS609; Autonomously replicating sequence on
Chromosome VI; activated very late in S phase in
37% of cell cycles; this origin is specifically fired in
the absence of RAD53 in the presence of hydroxyurea"
/db_xref="SGD:S000007641"
gene complement(<258855..>259433)
/locus_tag="YFR054C"
/db_xref="GeneID:850615"
mRNA complement(<258855..>259433)
/locus_tag="YFR054C"
/product="uncharacterized protein"
/transcript_id="NM_001348833.1"
/db_xref="GeneID:850615"
CDS complement(258855..259433)
/locus_tag="YFR054C"
/note="hypothetical protein; conserved among S. cerevisiae
strains"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_001335774.1"
/db_xref="GeneID:850615"
/db_xref="SGD:S000001950"
/translation="MLFAYSGCLAPQCIPDISSFKALPFRDTESRFTTDSSVISSRFS
SSFTSSSSKIIIITSIFSSKMDNEHVGASLIVSLSMASLILTNVFSFSSTSYSSQPSD
YIACSPSGIDDQPVAEPSGYTPVGSSSPHSGCITSGLDAIGYQSSLNEGQSTNASSRF
VTKVYSHSALTHIILHLLSILQKFYLQVSTIS"
gene <264204..>265226
/gene="IRC7"
/locus_tag="YFR055W"
/db_xref="GeneID:850616"
mRNA <264204..>265226
/gene="IRC7"
/locus_tag="YFR055W"
/product="cysteine-S-conjugate beta-lyase IRC7"
/transcript_id="NM_001180021.1"
/db_xref="GeneID:850616"
CDS 264204..265226
/gene="IRC7"
/locus_tag="YFR055W"
/EC_number="4.4.1.13"
/experiment="EXISTENCE:direct assay:GO:0006790 sulfur
compound metabolic process [PMID:21569935]"
/experiment="EXISTENCE:direct assay:GO:0019450 L-cysteine
catabolic process to pyruvate [PMID:21569935]"
/experiment="EXISTENCE:direct assay:GO:0047804
cysteine-S-conjugate beta-lyase activity [PMID:21569935]"
/experiment="EXISTENCE:mutant phenotype:GO:0006790 sulfur
compound metabolic process [PMID:21569935]"
/experiment="EXISTENCE:mutant phenotype:GO:0019450
L-cysteine catabolic process to pyruvate [PMID:21569935]"
/experiment="EXISTENCE:mutant phenotype:GO:0047804
cysteine-S-conjugate beta-lyase activity [PMID:21569935]"
/note="Cysteine desulphydrase, enables growth on cysteine
as nitrogen source; involved in the production of thiols;
null mutant displays increased levels of spontaneous
Rad52p foci; expression induced by nitrogen limitation in
a GLN3, GAT1-dependent manner and by copper levels in a
Mac1-dependent manner"
/codon_start=1
/product="cysteine-S-conjugate beta-lyase IRC7"
/protein_id="NP_116714.1"
/db_xref="GeneID:850616"
/db_xref="SGD:S000001952"
/translation="MIDRTELSKFGITTQLSVIGRNPDEQSGFVNPPLYKGSTIILKK
LSDLEQRKGRFYGTAGSPTIDNLENAWTHLTGGAGTVLSASGLGSISLALLALSKAGD
HILMTDSVYVPTRMLCDGLLAKFGVETDYYDPSIGKDIEKLVKPNTTVIFLESPGSGT
MEVQDIPALVSVAKKHGIKTILDNTWATPLFFDAHAHGIDISVEAGTKYLGGHSDLLI
GLASANEECWPLLRSTYDAMAMLPGAEDCQLALRGMRTLHLRLKEVERKALDLAAWLG
NRDEVEKVLHPAFEDCPGHEYWVRDYKGSSGLFSIVLKNGFTRAGLEKMVEGMKVLQL
GFSWGG"
gene <269061..>269516
/locus_tag="YFR057W"
/db_xref="GeneID:850618"
mRNA <269061..>269516
/locus_tag="YFR057W"
/product="uncharacterized protein"
/transcript_id="NM_001180022.3"
/db_xref="GeneID:850618"
CDS 269061..269516
/locus_tag="YFR057W"
/note="Telomere-linked gene, silencing of which is
strictly Sir2-dependent"
/codon_start=1
/product="uncharacterized protein"
/protein_id="NP_116715.3"
/db_xref="GeneID:850618"
/db_xref="SGD:S000001953"
/translation="MIFGPTSVYSKCSAKSSGIIKDTAKLPISRVRIKVMLEITVSFL
FFDRFPRSFLNHNLYDSICPFFAWQYTSYYLSIYRQSFLFHFLQKDFSNDFVSEELIY
ALVALGAKNSFDNSLSKHTYEYYNHSKRNLLEDSTNKNSAFSSASVTKP"
rep_origin 269417..270035
/note="ARS610; Autonomously Replicating Sequence"
/db_xref="SGD:S000121260"
telomere 269731..270161
/note="TEL06R; Telomeric region on the right arm of
Chromosome VI; composed of an X element core sequence and
a short terminal stretch of telomeric repeats"
/db_xref="SGD:S000028957"
CONTIG join(BK006940.2:1..270161)
//