Database: RefSeq
Entry: NP_001119808
LinkDB: NP_001119808
Original site: NP_001119808 
LOCUS       NP_001119808             655 aa            linear   PRI 02-JUL-2019
DEFINITION  versican core protein isoform 2 precursor [Homo sapiens].
ACCESSION   NP_001119808
VERSION     NP_001119808.1
DBSOURCE    REFSEQ: accession NM_001126336.3
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 655)
  AUTHORS   Tang PH, Velez G, Tsang SH, Bassuk AG and Mahajan VB.
  TITLE     VCAN Canonical Splice Site Mutation is Associated With
            Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site
  JOURNAL   Invest. Ophthalmol. Vis. Sci. 60 (1), 282-293 (2019)
   PUBMED   30657523
  REMARK    GeneRIF: The intronic VCAN mutation removes an MMP cleavage site,
            which alters versican structure and results in abnormal vitreous
            modeling. Disruption of a versican protein network may underlie
            clinicopathologic disease features and point to targeted therapies.
REFERENCE   2  (residues 1 to 655)
  AUTHORS   Kenagy RD, Kikuchi S, Evanko SP, Ruiter MS, Piola M, Longchamp A,
            Pesce M, Soncini M, Deglise S, Fiore GB, Haefliger JA, Schmidt TA,
            Majesky MW, Sobel M and Wight TN.
  TITLE     Versican is differentially regulated in the adventitial and medial
            layers of human vein grafts
  JOURNAL   PLoS ONE 13 (9), e0204045 (2018)
   PUBMED   30265729
  REMARK    GeneRIF: Examined the production and distribution of versican and
            hyaluronan in intact vein rings cultured ex vivo, veins perfused ex
            vivo, and cultured venous adventitial and smooth muscle cells.
            Immunohistochemistry revealed higher levels of versican in the
            intima/media compared to the adventitia, and no differences in
            hyaluronan. In the vasa vasorum, versican and hyaluronan associated
            with CD34+ progenitor cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 655)
  AUTHORS   Araujo JR, Tavares-Ferreira J, Estrela-Silva S, Rocha P, Brandao E,
            Faria PA, Falcao-Reis F and Rocha-Sousa A.
  TITLE     WAGNER syndrome: anatomic, functional and genetic characterization
            of a Portuguese family
  JOURNAL   Graefes Arch. Clin. Exp. Ophthalmol. 256 (1), 163-171 (2018)
   PUBMED   29071374
  REMARK    GeneRIF: The macular dysfunction on mfERG was profound and of early
            onset. A heterozygous mutation in intron 7 of the VCAN gene
            (c.4004-1G > A) was found.
REFERENCE   4  (residues 1 to 655)
  AUTHORS   Zako M, Shinomura T, Ujita M, Ito K and Kimata K.
  TITLE     Expression of PG-M(V3), an alternatively spliced form of PG-M
            without a chondroitin sulfate attachment in region in mouse and
            human tissues
  JOURNAL   J. Biol. Chem. 270 (8), 3914-3918 (1995)
   PUBMED   7876137
REFERENCE   5  (residues 1 to 655)
  AUTHORS   Naso MF, Zimmermann DR and Iozzo RV.
  TITLE     Characterization of the complete genomic structure of the human
            versican gene and functional analysis of its promoter
  JOURNAL   J. Biol. Chem. 269 (52), 32999-33008 (1994)
   PUBMED   7528742
REFERENCE   6  (residues 1 to 655)
  AUTHORS   Kloeckener-Gruissem,B. and Amstutz,C.
  TITLE     VCAN-Related Vitreoretinopathy
  JOURNAL   (in) Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens
            K and Amemiya A (Eds.);
   PUBMED   20301747
REFERENCE   7  (residues 1 to 655)
  AUTHORS   Iozzo RV, Naso MF, Cannizzaro LA, Wasmuth JJ and McPherson JD.
  TITLE     Mapping of the versican proteoglycan gene (CSPG2) to the long arm
            of human chromosome 5 (5q12-5q14)
  JOURNAL   Genomics 14 (4), 845-851 (1992)
   PUBMED   1478664
REFERENCE   8  (residues 1 to 655)
  AUTHORS   Perides G, Rahemtulla F, Lane WS, Asher RA and Bignami A.
  TITLE     Isolation of a large aggregating proteoglycan from human brain
  JOURNAL   J. Biol. Chem. 267 (33), 23883-23887 (1992)
   PUBMED   1429726
REFERENCE   9  (residues 1 to 655)
  AUTHORS   Perides G, Lane WS, Andrews D, Dahl D and Bignami A.
  TITLE     Isolation and partial characterization of a glial
            hyaluronate-binding protein
  JOURNAL   J. Biol. Chem. 264 (10), 5981-5987 (1989)
   PUBMED   2466833
REFERENCE   10 (residues 1 to 655)
  AUTHORS   Bignami A, Lane WS, Andrews D and Dahl D.
  TITLE     Structural similarity of hyaluronate binding proteins in brain and
  JOURNAL   Brain Res. Bull. 22 (1), 67-70 (1989)
   PUBMED   2469524
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA361670.1, D32039.1,
            BC050524.1, DT217515.1 and AC026696.5.
            Summary: This gene is a member of the aggrecan/versican
            proteoglycan family. The protein encoded is a large chondroitin
            sulfate proteoglycan and is a major component of the extracellular
            matrix. This protein is involved in cell adhesion, proliferation,
            proliferation, migration and angiogenesis and plays a central role
            in tissue morphogenesis and maintenance. Mutations in this gene are
            the cause of Wagner syndrome type 1. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2009].
            Transcript Variant: This variant (2), also known as PG-M(V3), omits
            two coding exons, compared to variant 1. This results in a shorter
            protein (isoform 2) with no chondroitin sulfate attachment domain.
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            Transcript exon combination :: SRR1803613.71064.1, D32039.1
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Homo sapiens"
     Protein         1..655
                     /product="versican core protein isoform 2 precursor"
                     /note="versican proteoglycan; versican core protein; glial
                     hyaluronate-binding protein; large fibroblast
                     proteoglycan; chondroitin sulfate proteoglycan core
                     protein 2"
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     mat_peptide     21..655
                     /product="versican core protein isoform 2"
     Region          29..147
                     /note="Immunoglobulin like; smart00410"
     Region          36..151
                     /note="Immunoglobulin (Ig)-like domain of the chondroitin
                     sulfate proteoglycan core protein (CSPG), versican;
     Region          150..244
                     /note="Link_domain_CSPGs_modules_1_3; this extracellular
                     link domain is found in the first and third link modules
                     of the chondroitin sulfate proteoglycan core protein
                     (CSPG) aggrecan. In addition, it is found in the first
                     link module of three other CSPGs:...; cd03517"
     Site            160..161
                     /note="putative hyaluronan binding site [chemical
     Region          251..346
                     /note="Link_domain_CSPGs_modules_2_4; this link domain is
                     found in the second and fourth link modules of the
                     chondroitin sulfate proteoglycan core protein (CSPG)
                     aggrecan and, in the second link module of three other
                     CSPGs: versican, neurocan, and brevican. The...; cd03520"
     Site            258..259
                     /note="putative hyaluronan binding site [chemical
     Region          350..384
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
     Region          386..422
                     /note="Calcium-binding EGF-like domain, present in a large
                     number of membrane-bound and extracellular (mostly animal)
                     proteins. Many of these proteins require calcium for their
                     biological function and calcium-binding sites have been
                     found to be located at the...; cd00054"
     Site            order(386,389,403)
                     /note="Ca2+ binding site [ion binding]"
     Region          428..551
                     /note="C-type lectin (CTL)/C-type lectin-like (CTLD)
                     domain; cl02432"
     Site            order(522,526,528,534,536..539,542..544)
                     /note="ligand binding surface [chemical binding]"
     Region          555..611
                     /note="Complement control protein (CCP) modules (aka short
                     consensus repeats SCRs or SUSHI repeats) have been
                     identified in several proteins of the complement system;
     Site            order(565,585)
                     /note="receptor-ligand interactions"
     CDS             1..655
                     /gene_synonym="CSPG2; ERVR; GHAP; PG-M; WGN; WGN1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
        1 mfiniksilw mcstlivtha lhkvkvgksp pvrgslsgkv slpchfstmp tlppsyntse
       61 flrikwskie vdkngkdlke ttvlvaqngn ikigqdykgr vsvpthpeav gdasltvvkl
      121 lasdaglyrc dvmygiedtq dtvsltvdgv vfhyraatsr ytlnfeaaqk acldvgavia
      181 tpeqlfaaye dgfeqcdagw ladqtvrypi raprvgcygd kmgkagvrty gfrspqetyd
      241 vycyvdhldg dvfhltvpsk ftfeeaakec enqdarlatv gelqaawrng fdqcdygwls
      301 dasvrhpvtv araqcgggll gvrtlyrfen qtgfpppdsr fdaycfkrpd rckmnpclng
      361 gtcyptetsy vctcvpgysg dqceldfdec hsnpcrngat cvdgfntfrc lclpsyvgal
      421 ceqdtetcdy gwhkfqgqcy kyfahrrtwd aaerecrlqg ahltsilshe eqmfvnrvgh
      481 dyqwiglndk mfehdfrwtd gstlqyenwr pnqpdsffsa gedcvviiwh engqwndvpc
      541 nyhltytckk gtvacgqppv venaktfgkm kpryeinsli ryhckdgfiq rhlptirclg
      601 ngrwaipkit cmnpsayqrt ysmkyfknss sakdnsints khdhrwsrrw qesrr
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