LOCUS NC_001407 9392 bp ss-RNA linear VRL 13-AUG-2018
DEFINITION Rous sarcoma virus, complete genome.
ACCESSION NC_001407
VERSION NC_001407.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Rous sarcoma virus
ORGANISM Rous sarcoma virus
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
REFERENCE 1 (bases 1 to 9392)
AUTHORS Petropoulos,C.J.
TITLE Appendix 2: Retroviral taxonomy, protein structure, sequences, and
genetic maps
JOURNAL (in) Coffin,J.M. (Ed.);
RETROVIRUSES: 757;
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York,
NY, USA (1997)
REFERENCE 2 (bases 1 to 9392)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (03-SEP-2004) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 9392)
AUTHORS Chappey,C.
TITLE Direct Submission
JOURNAL Submitted (12-NOV-1997) NIH, NLM, Rockville Pike, Bethesda, MD
20894, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AF033808.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..9392
/organism="Rous sarcoma virus"
/mol_type="genomic RNA"
/db_xref="taxon:11886"
gene 1..9392
/locus_tag="RSVgp1"
/db_xref="GeneID:2193432"
mRNA 1..9392
/gene="gag-pol"
mRNA join(1..397,5078..9392)
/gene="env"
/product="gPr95 polyprotein precursor"
5'UTR 22..102
CDS join(380..397,5078..6865)
/gene="env"
/codon_start=1
/product="gPr95 polyprotein precursor"
/protein_id="NP_056885.1"
/translation="MEAVIKAFLTGYPGKTSKKDSKEKPLATSKKDPEKTPLLPTRVN
YILIIGVLVLCEVTGVRADVHLLEQPGNLWITWANRTGQTDFCLSTQSATSPFQTCLI
GIPSPISEGDFKGYVSDTNCSTVGTDRLVLSASITGGPDNSTTLTYRKVSCLLLKLNV
SMWDEPPELQLLGSQSLPNVTNITQVSGVAGGCVYFAPRATGLFLGWSKQGLSRFLLR
HPFTSTSNSTEPFTVVTADRHNLFMGSEYCGAYGYRFWEIYNCSQTRNTYRCGDVGGT
GLPETWCRGKGGIWVNQSKEINETEPFSFTANCTGSNLGNVSGCCGEPITILPLGAWI
DSTQGSFTKPKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDILKILA
NSSRTGIRRKRSVSHLDDTCSDEVQLWGPTARIFASILAPGVAAAQALREIERLACWS
VKQANLTTSLLGDLLDDVTSIRHAVLQNRAAIDFLLLAHGHGCEDVAGMCCFNLSDHS
ESIQKKFQLMKKHVNKIGVDSDPIGSWLRGIFGGIGEWAVHLLKGLLLGLVVILLLLV
CLPCLLQFVSSSIRKMINSSINYHTEYRKMQGGAV"
mat_peptide 5249..6268
/gene="env"
/product="gp85 SU"
/protein_id="NP_955614.1"
misc_feature 5531..6271
/gene="env"
/note="Avian retrovirus envelope protein, gp85; Region:
Avian_gp85; pfam03708"
/db_xref="CDD:281671"
mat_peptide 6269..6862
/gene="env"
/product="gp37 TM"
/protein_id="NP_955615.1"
misc_feature 6404..6619
/gene="env"
/note="heptad repeat 1-heptad repeat 2 region (ectodomain)
of the transmembrane subunit of Rous sarcoma virus (RSV),
and related domains; Region: RSV-like_HR1-HR2; cd09949"
/db_xref="CDD:197372"
misc_feature order(6404..6412,6416..6421,6425..6430,6434..6442,
6446..6454,6458..6463,6467..6475,6479..6505,6509..6517,
6542..6547,6554..6556,6563..6574,6578..6580,6596..6598,
6605..6610,6617..6619)
/gene="env"
/note="homotrimer interface [polypeptide binding]; other
site"
/db_xref="CDD:197372"
misc_feature 6404..6517
/gene="env"
/note="HR1; other site"
/db_xref="CDD:197372"
misc_feature 6485..6535
/gene="env"
/note="immunosuppressive region; other site"
/db_xref="CDD:197372"
misc_feature 6491..6493
/gene="env"
/note="Cl binding site [ion binding]; other site"
/db_xref="CDD:197372"
misc_feature 6536..6559
/gene="env"
/note="CX(6)C motif; other site"
/db_xref="CDD:197372"
misc_feature 6593..6619
/gene="env"
/note="HR2; other site"
/db_xref="CDD:197372"
CDS join(380..2482,2482..5190)
/gene="gag-pol"
/ribosomal_slippage
/codon_start=1
/product="Pr180 polyprotein precursor"
/protein_id="NP_056886.1"
/translation="MEAVIKVISSACKTYCGKTSPSKKEIGAMLSLLQKEGLLMSPSD
LYSPGSWDPITAALSQRAMILGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGG
GRVSPPGPECIEKPATERRIDKGEEVGETTVQRDAKMAPEETATPKTVGTSCYHCGTA
IGCNCATASAPPPPYVGSGLYPSLAGVGEQQGQGGDTPPGAEQSRAEPGHAGQAPGPA
LTDWARVREELASTGPPVVAMPVVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITM
AEVEALMSSPLLPHDVTNLMRVILGPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQ
GRGERTNLNRLKGLADGMVGNPQGQAALLRPGELVAITASALQAFREVARLAEPAGPW
ADIMQGPSESFVDFANRLIKAVEGSDLPPSARAPVIIDCFRQKSQPDIQQLIRTAPST
LTTPGEIIKYVLDRQKTAPLTDQGIAAAMSSAIQPLIMAVVNRERDGQTGSGGRARGL
CYTCGSPGHYQAQCPKKRKSGNSRERCQLCNGMGHNAKQCRKRDGNQGQRPGKGLSSG
PWPGPEPPAVSLAMTMEHKDRPLVRVILTNTGSHPVKQRSVYITALLDSGADITIISE
EDWPTDWPVMEAANPQIHGIGGGIPMRKSRDMIELGVINRDGSLERPLLLFPAVAMVR
GSILGRDCLQGLGLRLTNLIGRATVLTVALHLAIPLKWKPDHTPVWIDQWPLPEGKLV
ALTQLVEKELQLGHIEPSLSCWNTPVFVIRKASGSYRLLHDLRAVNAKLVPFGAVQQG
APVLSALPRGWPLMVLDLKDCFFSIPLAEQDREAFAFTLPSVNNQAPARRFQWKVLPQ
GMTCSPTICQLVVGQVLEPLRLKHPSLCMLHYMDDLLLAASSHDGLEAAGEEVISTLE
RAGFTISPDKVQREPGVQYLGYKLGSTYVAPVGLVAEPRIATLWDVQKLVGSLQWLRP
ALGIPPRLMGPFYEQLRGSDPNEAREWNLDMKMAWREIVRLSTTAALERWDPALPLEG
AVARCEQGAIGVLGQGLSTHPRPCLWLFSTQPTKAFTAWLEVLTLLITKLRASAVRTF
GKEVDILLLPACFREDLPLPEGILLALKGFAGKIRSSDTPSIFDIARPLHVSLKVRVT
DHPVPGPTVFTDASSSTHKGVVVWREGPRWEIKEIADLGASVQQLEARAVAMALLLWP
TTPTNVVTDSAFVAKMLLKMGQEGVPSTAAAFILEDALSQRSAMAAVLHVRSHSEVPG
FFTEGNDVADSQATFQAYPLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHC
NSAPALEAGVNPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTS
VAVQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNSQGQAMV
ERANRLLKDRIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFERGENTKTPIQKHWR
PTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVKNRDTDKVIWVPSRKVKPDITQK
DEVTKKDEASPLFAGISDWIPWEDEQEGLQGETASNKQERPGEDTLAANES"
misc_feature 383..640
/gene="gag-pol"
/note="Retroviral M domain; Region: Retro_M; pfam02813"
/db_xref="CDD:280904"
misc_feature 1124..1537
/gene="gag-pol"
/note="gag gene protein p24 (core nucleocapsid protein);
Region: Gag_p24; pfam00607"
/db_xref="CDD:425774"
misc_feature 1553..>1714
/gene="gag-pol"
/note="Gag protein p24 C-terminal domain; Region:
Gag_p24_C; pfam19317"
/db_xref="CDD:437149"
misc_feature <1856..2065
/gene="gag-pol"
/note="universal minicircle sequence binding protein
(UMSBP); Provisional; Region: PTZ00368"
/db_xref="CDD:173561"
mat_peptide join(2102..2482,2482..2502)
/gene="gag-pol"
/product="p15 PR"
/protein_id="NP_955613.1"
misc_feature 2129..2476
/gene="gag-pol"
/note="Retroviral aspartyl protease; Region: RVP;
pfam00077"
/db_xref="CDD:425454"
misc_feature order(2219..2221,2225..2227,2231..2233,2297..2305,
2432..2434)
/gene="gag-pol"
/note="inhibitor binding site [active]"
/db_xref="CDD:133149"
misc_feature 2219..2227
/gene="gag-pol"
/note="catalytic motif [active]"
/db_xref="CDD:133149"
misc_feature 2219..2221
/gene="gag-pol"
/note="Catalytic residue [active]"
/db_xref="CDD:133149"
misc_feature order(2297..2311,2315..2329)
/gene="gag-pol"
/note="Active site flap [active]"
/db_xref="CDD:133149"
mat_peptide 2503..4218
/gene="gag-pol"
/product="p68a RT"
/protein_id="NP_955611.1"
misc_feature 2554..3192
/gene="gag-pol"
/note="Reverse transcriptases (RTs) from retroviruses
(Rtvs). RTs catalyze the conversion of single-stranded RNA
into double-stranded viral DNA for integration into host
chromosomes. Proteins in this subfamily contain long
terminal repeats (LTRs) and are...; Region: RT_Rtv;
cd01645"
/db_xref="CDD:238823"
misc_feature order(2572..2577,2677..2679,2689..2691,2707..2709,
2713..2721,2725..2727,2734..2736,2758..2760,2764..2769,
2773..2775,2821..2838,2944..2949,2953..2955,2962..2964,
3040..3042,3046..3051,3178..3183)
/gene="gag-pol"
/note="active site"
/db_xref="CDD:238823"
misc_feature order(2572..2577,2713..2721,2725..2727,2734..2736,
2758..2760,2764..2769,2773..2775,2947..2949,2953..2955,
2962..2964,3040..3042,3178..3183)
/gene="gag-pol"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:238823"
misc_feature order(2689..2691,2707..2709,2821..2838,2944..2946,
3046..3048)
/gene="gag-pol"
/note="dNTP binding site [chemical binding]; other site"
/db_xref="CDD:238823"
misc_feature order(2791..2802,3028..3030,3034..3036,3055..3057,
3061..3063,3169..3171)
/gene="gag-pol"
/note="NNRTI binding site [active]"
/db_xref="CDD:238823"
misc_feature 3235..3375
/gene="gag-pol"
/note="Reverse transcriptase thumb domain; Region:
RVT_thumb; pfam06817"
/db_xref="CDD:429135"
misc_feature 3838..4215
/gene="gag-pol"
/note="Ribonuclease H-like superfamily, including RNase H,
HI, HII, HIII, and RNase-like domain IV of spliceosomal
protein Prp8; Region: RNase_H_like; cl14782"
/db_xref="CDD:449355"
misc_feature order(3850..3861,3940..3945,3952..3954,4015..4017,
4135..4137,4204..4206)
/gene="gag-pol"
/note="RNA/DNA hybrid binding site [nucleotide binding];
other site"
/db_xref="CDD:259998"
mat_peptide 4219..5187
/gene="gag-pol"
/product="p32 IN"
/protein_id="NP_955612.1"
misc_feature 4237..4344
/gene="gag-pol"
/note="Integrase Zinc binding domain; Region:
Integrase_Zn; pfam02022"
/db_xref="CDD:426567"
misc_feature 4387..4668
/gene="gag-pol"
/note="Integrase core domain; Region: rve; pfam00665"
/db_xref="CDD:425808"
gene 380..2485
/gene="gag"
/locus_tag="RSVgp2"
/db_xref="GeneID:1491923"
CDS 380..2485
/gene="gag"
/locus_tag="RSVgp2"
/codon_start=1
/product="Pr76 polyprotein precursor"
/protein_id="NP_056887.1"
/db_xref="GeneID:1491923"
/translation="MEAVIKVISSACKTYCGKTSPSKKEIGAMLSLLQKEGLLMSPSD
LYSPGSWDPITAALSQRAMILGKSGELKTWGLVLGALKAAREEQVTSEQAKFWLGLGG
GRVSPPGPECIEKPATERRIDKGEEVGETTVQRDAKMAPEETATPKTVGTSCYHCGTA
IGCNCATASAPPPPYVGSGLYPSLAGVGEQQGQGGDTPPGAEQSRAEPGHAGQAPGPA
LTDWARVREELASTGPPVVAMPVVIKTEGPAWTPLEPKLITRLADTVRTKGLRSPITM
AEVEALMSSPLLPHDVTNLMRVILGPAPYALWMDAWGVQLQTVIAAATRDPRHPANGQ
GRGERTNLNRLKGLADGMVGNPQGQAALLRPGELVAITASALQAFREVARLAEPAGPW
ADIMQGPSESFVDFANRLIKAVEGSDLPPSARAPVIIDCFRQKSQPDIQQLIRTAPST
LTTPGEIIKYVLDRQKTAPLTDQGIAAAMSSAIQPLIMAVVNRERDGQTGSGGRARGL
CYTCGSPGHYQAQCPKKRKSGNSRERCQLCNGMGHNAKQCRKRDGNQGQRPGKGLSSG
PWPGPEPPAVSLAMTMEHKDRPLVRVILTNTGSHPVKQRSVYITALLDSGADITIISE
EDWPTDWPVMEAANPQIHGIGGGIPMRKSRDMIELGVINRDGSLERPLLLFPAVAMVR
GSILGRDCLQGLGLRLTNL"
mat_peptide 380..844
/gene="gag"
/locus_tag="RSVgp2"
/product="p19"
/protein_id="NP_955607.1"
misc_feature 383..640
/gene="gag"
/locus_tag="RSVgp2"
/note="Retroviral M domain; Region: Retro_M; pfam02813"
/db_xref="CDD:280904"
mat_peptide 911..1096
/gene="gag"
/locus_tag="RSVgp2"
/product="pp10"
/protein_id="NP_955608.1"
mat_peptide 1097..1816
/gene="gag"
/locus_tag="RSVgp2"
/product="p27 CA"
/protein_id="NP_955609.1"
misc_feature 1124..1537
/gene="gag"
/locus_tag="RSVgp2"
/note="gag gene protein p24 (core nucleocapsid protein);
Region: Gag_p24; pfam00607"
/db_xref="CDD:425774"
misc_feature 1553..>1714
/gene="gag"
/locus_tag="RSVgp2"
/note="Gag protein p24 C-terminal domain; Region:
Gag_p24_C; pfam19317"
/db_xref="CDD:437149"
mat_peptide 1844..2110
/gene="gag"
/locus_tag="RSVgp2"
/product="p12 NC"
/protein_id="NP_955610.1"
misc_feature <1868..2065
/gene="gag"
/locus_tag="RSVgp2"
/note="universal minicircle sequence binding protein
(UMSBP); Provisional; Region: PTZ00368"
/db_xref="CDD:173561"
misc_feature 2129..2476
/gene="gag"
/locus_tag="RSVgp2"
/note="Retroviral aspartyl protease; Region: RVP;
pfam00077"
/db_xref="CDD:425454"
misc_feature order(2219..2221,2225..2227,2231..2233,2297..2305,
2432..2434)
/gene="gag"
/locus_tag="RSVgp2"
/note="inhibitor binding site [active]"
/db_xref="CDD:133149"
misc_feature 2219..2227
/gene="gag"
/locus_tag="RSVgp2"
/note="catalytic motif [active]"
/db_xref="CDD:133149"
misc_feature 2219..2221
/gene="gag"
/locus_tag="RSVgp2"
/note="Catalytic residue [active]"
/db_xref="CDD:133149"
misc_feature order(2297..2311,2315..2329)
/gene="gag"
/locus_tag="RSVgp2"
/note="Active site flap [active]"
/db_xref="CDD:133149"
gene 2482..5190
/gene="pol"
/locus_tag="RSVgp3"
/db_xref="GeneID:1491924"
gene 7129..8709
/gene="src"
/locus_tag="RSVgp4"
/db_xref="GeneID:1491925"
mRNA 7129..8709
/gene="src"
/locus_tag="RSVgp4"
/product="p60 src"
/db_xref="GeneID:1491925"
CDS 7129..8709
/gene="src"
/locus_tag="RSVgp4"
/note="p60-SRC phosphoprotein"
/codon_start=1
/product="p60 src"
/protein_id="NP_056888.1"
/db_xref="GeneID:1491925"
/translation="MGSSKSKPKDPSQRRHSLEPPDSTHHGGFPASQTPDETAAPDAH
RNPSRSFGTVATEPKLFWGFNTSDTVTSPQRAGALAGGVTTFVALYDYESWTETDLSF
KKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESER
LLLNPENPRGTFLVRKSETAKGAYCLSVSDFDNAKGPNVKHYKIYKLYSGGFYITSRT
QFGSLQQLVAYYSKHADGLCHRLANVCPTSKPQTQGLAKDAWEIPRESLRLEAKLGQG
CFGEVWMGTWNDTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPI
YIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI
LVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI
LLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPT
FKYLQAQLLPACVLEVAE"
mat_peptide 7132..8706
/gene="src"
/locus_tag="RSVgp4"
/product="pp60 SRC"
/protein_id="NP_955616.1"
misc_feature 7381..7548
/gene="src"
/locus_tag="RSVgp4"
/note="Src homology 3 domain of Src Protein Tyrosine
Kinase; Region: SH3_Src; cd12008"
/db_xref="CDD:212941"
misc_feature order(7381..7404,7411..7416,7420..7434,7444..7461,
7465..7467,7471..7473,7477..7506,7510..7524,7534..7548)
/gene="src"
/locus_tag="RSVgp4"
/note="swapped dimer interface [polypeptide binding];
other site"
/db_xref="CDD:212941"
misc_feature order(7396..7398,7402..7416,7423..7425,7471..7482,
7519..7521,7525..7527,7531..7536)
/gene="src"
/locus_tag="RSVgp4"
/note="peptide ligand binding site [polypeptide binding];
other site"
/db_xref="CDD:212941"
misc_feature 7558..7860
/gene="src"
/locus_tag="RSVgp4"
/note="Src homology 2 (SH2) domain; Region: SH2; cl15255"
/db_xref="CDD:449520"
misc_feature order(7591..7593,7651..7653,7729..7731,7735..7737)
/gene="src"
/locus_tag="RSVgp4"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198173"
misc_feature order(7732..7734,7813..7815)
/gene="src"
/locus_tag="RSVgp4"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198173"
misc_feature 7942..8676
/gene="src"
/locus_tag="RSVgp4"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl21453"
/db_xref="CDD:451246"
misc_feature order(7945..7956,7963..7965,7969..7971,8005..8007,
8011..8013,8095..8097,8140..8151,8284..8286,8296..8301,
8305..8307,8335..8340)
/gene="src"
/locus_tag="RSVgp4"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:270870"
3'UTR 9058..9292
/locus_tag="RSVgp1"
ORIGIN
1 gccattttac cattcaccac attggtgtgc acctgggttg atggccggac cgtcgattcc
61 ctaacgattg cgaacacctg aatgaagcag aaggcttcat ttggtgaccc cgacgtgata
121 gttagggaat agtggtcggc cacagacggc gtggcgatcc tgccctcatc cgtctcgctt
181 attcggggag cggacgatga ccctagtaga gggggctgcg gcttaggagg gcagaagctg
241 agtggcgtcg gagggagctc tactgcaggg agcccagata ccctaccgag aactcagaga
301 gtcgttggaa gacgggaagg aagcccgacg actgagcagt ccaccccagg cgtgattctg
361 gtcgcccggt ggatcaagca tggaagccgt cataaaggtg atttcgtccg cgtgtaaaac
421 ctattgcggg aaaacctctc cttctaagaa ggaaataggg gccatgttgt ccctcttaca
481 aaaggaaggg ttgcttatgt ctccctcaga cttatattcc ccggggtcct gggatcccat
541 taccgcggcg ctatcccagc gggctatgat acttgggaaa tcgggagagt taaaaacctg
601 gggattggtt ttgggggcat tgaaggcggc tcgagaggaa caggttacat ctgagcaagc
661 aaagttttgg ttgggattag ggggagggag ggtctctccc ccaggtccgg agtgcatcga
721 gaaaccagca acggagcggc gaatcgacaa aggggaggaa gtgggagaaa caactgtgca
781 gcgagatgcg aagatggcgc cggaggaaac ggccacacct aaaaccgttg gcacatcctg
841 ctatcattgc ggaacagcta ttggctgtaa ttgcgccaca gcctcggctc ctcctcctcc
901 ttatgtgggg agtggtttgt atccttccct ggcgggggtg ggagagcagc agggccaggg
961 gggtgacaca cctccggggg cggaacagtc aagggcggag ccagggcatg cgggtcaggc
1021 tcctgggccg gccctgactg actgggcaag ggtcagggag gagcttgcga gtactggtcc
1081 gcccgtggtg gccatgcctg tagtgattaa gacagaggga cccgcttgga cccctctgga
1141 gccaaaattg atcacaagac tggctgatac ggtcaggacc aagggcttac gatccccgat
1201 tactatggca gaagtggaag cgcttatgtc ctccccgctg ctgccgcatg acgtcacgaa
1261 tctaatgaga gttattttag ggcctgcccc atatgcctta tggatggacg cttggggagt
1321 ccaactccag acagttatag cggcagccac tcgcgacccc cgacacccag cgaacggtca
1381 agggcggggg gaacggacta atttgaatcg cttaaagggc ttagctgatg ggatggtggg
1441 caacccacag ggtcaggccg cattattaag accgggggaa ttggttgcta ttacggcgtc
1501 ggctctccag gcgtttagag aggttgcccg gctggcggaa cctgcaggtc catgggcgga
1561 catcatgcag ggaccatctg agtcctttgt tgattttgcc aatcggctta taaaggcggt
1621 tgaggggtca gatctcccgc cttccgcgcg ggctccggtg atcattgact gctttaggca
1681 gaagtcacag ccagatattc agcagcttat acggacagca ccctccacgc tgaccacccc
1741 aggagagata attaaatatg tgctagacag gcagaagact gcccctctta cggatcaagg
1801 catagccgcg gccatgtcgt ctgctatcca gcccttaatt atggcagtag tcaatagaga
1861 gagggatgga caaactgggt cgggtggtcg tgcccgaggg ctctgctaca cttgtggatc
1921 cccgggacat tatcaggcgc agtgcccgaa aaaacggaag tcaggaaaca gccgtgagcg
1981 atgtcagttg tgtaacggga tgggacacaa cgctaaacag tgtaggaagc gggatggcaa
2041 ccagggccaa cgcccaggaa aaggtctctc ttcggggccg tggcccggcc ctgagccacc
2101 tgccgtctcg ttagcgatga caatggaaca taaagatcgc cccttggtta gggtcattct
2161 gactaacact gggagtcatc cggtcaaaca gcgttcggtg tatatcaccg cgctgttgga
2221 ctctggagcg gacatcacta ttatttcaga ggaggattgg cccaccgatt ggccagtgat
2281 ggaggccgcg aacccgcaga tccatgggat aggaggggga attcccatgc gaaaatctcg
2341 tgacatgata gagttggggg ttattaaccg agacgggtct ttggagcgac ccctgctcct
2401 cttccccgca gtagctatgg ttagagggag tatcctagga agagattgtc tgcagggcct
2461 agggctccgc ttgacaaatt tatagggagg gccactgttc tcactgttgc gctacatctg
2521 gctattccgc tcaaatggaa gccagaccac acgcctgtgt ggattgacca gtggcccctc
2581 cctgaaggta aacttgtagc gctaacgcaa ttagtggaaa aagaattaca gttaggacat
2641 atagaacctt cacttagttg ttggaacaca cctgtcttcg tgatccggaa ggcttccggg
2701 tcttaccgct tactgcatga tttgcgcgct gttaacgcca agcttgttcc ttttggggcc
2761 gtccaacagg gggcgccagt tctctccgcg ctcccgcgtg gctggcccct gatggtctta
2821 gacctcaagg attgcttctt ttctatccct cttgcggaac aagatcgcga agcttttgca
2881 tttacgctcc cctctgtgaa taaccaggcc cccgctcgaa gattccaatg gaaggtcttg
2941 ccccaaggga tgacctgttc tcccactatc tgtcagttgg tagtgggtca ggtacttgag
3001 cccttgcgac tcaagcaccc atctctgtgc atgttgcatt atatggatga tcttttgcta
3061 gccgcctcaa gtcacgatgg gttggaagcg gcaggggagg aggttatcag tacattggaa
3121 agagccgggt tcactatttc gcctgataag gtccagaggg agcccggagt acaatatctt
3181 gggtacaagt taggcagtac gtatgtagca cccgtaggcc tggtagcaga acccaggata
3241 gccaccttgt gggatgttca aaagctggtg gggtcacttc agtggcttcg cccagcgtta
3301 ggaatcccgc cacgactgat gggccccttc tatgagcagt tacgagggtc agatcctaac
3361 gaggcgaggg aatggaatct agacatgaaa atggcctgga gagagatcgt acggcttagc
3421 accactgctg ccttggaacg atgggaccct gccctgcctc tggaaggagc ggtcgctaga
3481 tgtgaacagg gggcaatagg ggttttggga cagggactgt ccacacaccc aaggccatgc
3541 ttgtggttat tctccaccca acccaccaag gcgtttactg cttggttaga agtgctcacc
3601 cttttgatta ctaagctacg tgcttcggca gtgcgaacct ttggcaagga ggtcgatatc
3661 ctcctgttgc ctgcatgctt tcgggaggac cttccgctcc cagaggggat cctgttagcc
3721 cttaaggggt ttgcaggaaa aatcaggagt agtgacacgc catctatttt tgacattgcg
3781 cgtccactgc atgtttctct gaaagtgagg gttaccgacc accctgtgcc gggacccact
3841 gtctttactg acgcctcctc aagcacccat aagggggtgg tagtctggag ggagggccca
3901 aggtgggaga taaaagaaat agctgatttg ggggcaagtg tacaacaact ggaagcacgc
3961 gctgtggcca tggcacttct gctgtggccg acaacgccca ctaatgtagt gactgactcc
4021 gcgtttgttg cgaaaatgtt actcaagatg ggacaggagg gagtcccgtc tacagcggcg
4081 gcttttattt tagaggatgc gttaagccaa aggtcagcca tggccgccgt tctccacgtg
4141 cggagtcatt ctgaagtgcc agggtttttc acagaaggaa atgacgtggc agatagccaa
4201 gccaccttcc aagcgtatcc cttgagagag gctaaagatc ttcataccgc tctccatatt
4261 ggaccccgcg cgctatccaa agcgtgtaat atatctatgc agcaggctag ggaggttgtt
4321 cagacctgcc cgcattgtaa ttcagcccct gcgttggagg ccggagtaaa ccctaggggt
4381 ttgggacccc tacagatatg gcagacagac tttacgcttg agcctagaat ggccccccgt
4441 tcctggctcg ctgttactgt ggataccgcc tcatcagcga tagtcgtaac tcagcatggc
4501 cgtgtcacat cggttgctgt acaacatcat tgggccacgg ctatcgccgt tttgggaaga
4561 ccaaaggcca taaaaacaga taatgggtcc tgcttcacgt ctaaatccac gcgagagtgg
4621 ctcgcgagat gggggatagc acacaccacc gggattccgg gtaattccca gggtcaagct
4681 atggtagagc gggccaaccg gctcctgaaa gataggatcc gtgtgcttgc ggagggggac
4741 ggctttatga aaagaatccc caccagcaaa cagggggaac tattagccaa ggcaatgtat
4801 gccctcaatc actttgagcg tggtgaaaac acgaaaacac cgatacaaaa acactggaga
4861 cctaccgttc ttacagaagg acccccggtt aaaatacgaa tagagacagg ggagtgggaa
4921 aaaggatgga acgtgctggt ctggggacga ggttatgccg ctgtgaaaaa cagggacact
4981 gataaggtta tttgggtacc ctctcgaaaa gttaaaccgg acatcaccca aaaggatgag
5041 gtgactaaga aagatgaggc gagccctctt tttgcaggca tttctgactg gataccctgg
5101 gaagacgagc aagaaggact ccaaggagaa accgctagca acaagcaaga aagacccgga
5161 gaagacaccc ttgctgccaa cgagagttaa ttatattctc attattggtg tcctggtctt
5221 gtgtgaggtt acgggggtaa gagctgatgt tcacttactc gagcagccag ggaacctttg
5281 gattacatgg gccaaccgta caggccaaac ggatttctgc ctctctacac agtcagccac
5341 ctcccctttt caaacatgtt tgataggtat cccgtctcct atttccgaag gtgattttaa
5401 gggatatgtt tctgatacaa attgctccac tgtgggaact gaccggttag tcttgtcagc
5461 cagcattacc ggcggccctg acaacagcac caccctcact tatcgaaagg tttcatgcct
5521 gctgttaaag ctgaacgtct ccatgtggga tgagccacct gaactgcagc tgctaggttc
5581 ccagtctctc cctaacgtta ctaacattac tcaggtctct ggcgtggccg ggggatgtgt
5641 atatttcgcc ccaagggcca ctggcctgtt tttaggttgg tctaaacaag gtctctcgcg
5701 gttcctcctc cgtcacccct ttacctccac ctctaactcc acggaaccgt tcacggtggt
5761 gacagcggat agacacaatc tttttatggg gagtgagtac tgtggtgcat atggctacag
5821 attttgggaa atatataact gctcacagac taggaatact taccgctgtg gagacgtggg
5881 aggtactggc ctccctgaaa cctggtgcag aggaaaagga ggtatatggg ttaatcaatc
5941 aaaggaaatt aatgagacag agccgttcag ttttactgcg aactgtactg gcagtaattt
6001 gggtaatgtc agcggatgtt gcggagaacc aatcacgatt ctcccactag gggcatggat
6061 cgacagtacg caaggtagtt tcactaaacc aaaagcgcta ccacccgcaa ttttcctcat
6121 ttgtggggat cgcgcatggc aaggaattcc cagtcgtccg gtagggggcc cctgctattt
6181 aggcaagctt accatgttag cacccaacca tacagatatt ctcaaaatac ttgctaattc
6241 gtcgcggaca ggtataagac gtaaacgaag cgtctcacac ctggatgata catgctcaga
6301 tgaagtacag ctttggggtc ctacagcaag aatctttgca tctatcttag ccccgggggt
6361 agcagctgcg caagccttaa gagaaattga gagactagcc tgttggtccg ttaaacaggc
6421 taacttgaca acatcactcc tcggggactt attggatgat gtcacgagta ttcgacacgc
6481 ggtcctgcag aaccgagcgg ctattgactt cttgcttcta gctcacggcc atggctgtga
6541 ggacgttgcc ggaatgtgtt gtttcaatct gagtgatcac agtgaatcta tacagaagaa
6601 gttccagcta atgaagaaac atgtcaataa gatcggcgtg gacagcgacc caatcggaag
6661 ttggctgcga gggatattcg ggggaatagg ggaatgggcc gttcatctgc taaaaggact
6721 gcttttgggg cttgtagtta ttttattgct actggtgtgc ctgccttgcc ttttacaatt
6781 tgtgtctagt agtattcgaa agatgattaa tagttcaatc aactatcata ctgaatacag
6841 gaagatgcag ggcggagcag tctagagctc agttataata atcctgcgaa tcgggctgta
6901 acggggcaag gcttgaccga ggggactata acatgtatag gcgaaaagcg gggtctcggt
6961 tgtaacgcgc ttaggaagtc ccctcgaggt atggcagata tgctcttgca tagggggaaa
7021 aaatgtagtc ttaatattgt ctgtgtgctg caggagctaa gctgactctg ctggtggcct
7081 cgcgtaccac tgtggccagg cggtagctgg gacgtgcagc cgaccaccat ggggagcagc
7141 aagagcaagc ctaaggaccc cagccagcgc cggcacagcc tggagccacc cgacagcacc
7201 caccacgggg gattcccagc ctcgcagacc cccgacgaga cagcagcccc cgacgcacac
7261 cgcaacccca gccgctcctt cgggaccgtg gccaccgagc ccaagctctt ctggggcttc
7321 aacacttctg acaccgtcac gtcgccgcag cgtgccgggg cactggctgg cggcgtcacc
7381 actttcgtgg ctctctacga ctacgagtcc tggactgaaa cggacttgtc cttcaagaaa
7441 ggagaacgcc tgcagattgt caacaacacg gaaggtgact ggtggctggc tcattccctc
7501 actacaggac agacgggcta catccccagt aactatgtcg cgccctcaga ctccatccag
7561 gctgaagagt ggtactttgg gaagatcact cgtcgggagt ccgagcggct gctgcttaac
7621 cccgaaaacc cccggggaac cttcttggtc cggaagagcg agacggcaaa gggtgcctat
7681 tgcctctccg tttctgactt tgacaacgcc aaggggccca atgtgaagca ctacaagatc
7741 tacaagctgt acagcggcgg cttctacatc acctcacgca cacagttcgg cagcctacag
7801 cagctggtgg cctactactc caaacatgct gatggcttgt gccaccgcct ggccaacgtc
7861 tgccccacgt ccaagcccca gacccaggga ctcgccaagg acgcgtggga aatcccccgg
7921 gagtcgctac ggctggaggc gaagctgggg cagggctgct ttggagaggt ctggatgggg
7981 acctggaacg acaccaccag agtggccata aagactctga agcccggcac catgtccccg
8041 gaggccttcc tgcaggaagc ccaagtgatg aagaagctcc ggcatgagaa gctggttcag
8101 ctgtacgcag tggtgtcgga agagcccatc tacatcgtca ttgagtacat gagcaagggg
8161 agcctcctgg atttcctgaa gggagagatg ggcaagtacc tgcggctgcc acagctcgtc
8221 gatatggctg ctcagattgc atccggcatg gcctatgtgg agagaatgaa ctacgtgcac
8281 cgagacctgc gggcggccaa catcctggtg ggggagaacc tggtgtgcaa ggtggctgac
8341 ttcgggctgg cacgcctcat cgaggacaac gagtacacag cacggcaagg tgccaagttc
8401 cccatcaagt ggacagcccc cgaggcagcc ctctatggcc ggttcaccat caagtcggat
8461 gtctggtcct tcggcatcct gctgactgag ctgaccacca agggccgggt gccataccca
8521 gggatggtca acagggaggt gctggaccag gtggagaggg gctaccgcat gccctgcccg
8581 cccgagtgcc ccgagtcgct gcatgacctc atgtgccagt gctggcggaa ggaccctgag
8641 gagcggccca cctttaagta cctgcaggcc cagctgctcc ctgcttgtgt gttggaggtc
8701 gctgagtaag tacgaggcgt gacctacaat tgctcaaata atgcttctgt agaaattgtt
8761 tagcattagg cgtcctgcgt tgctccgcga tgtacgggtc aggtataatg tgcagtttga
8821 ctgaggggac catgatgtgt ataggcgtca agcggggctt cggttgtacg cggataggaa
8881 tcccctcagg acaattctgc ttggaatatg atggcgtctt ccctgttttg cccttagact
8941 attcgagttg cctctgtgga ttagggctgg aggcagcacg gatagtctga tggccaaata
9001 aggcaggcaa gacagctatt tgtaactgcg aaatacgctt ttgcataggg agggggaaat
9061 gtagtcttat gcaatactcc tgtagtcttg caacatgctt atgtaacgat gagttagcaa
9121 tatgccttac aaggaaagaa aaggcaccgt gcatgccgat tggtggtagt aaggtggtac
9181 gatcgtgcct tattaggaag gtatcagacg ggtctaacat ggattggacg aaccactgaa
9241 ttccgcatcg cagagatatt gtatttaagt gcctagctcg atacaataaa cgccatttta
9301 ccattcacca cattggtgtg cacctgggtt gatggccgga ccgtcgattc cctaacgatt
9361 gcgaacacct gaatgaagca gaaggcttca tt
//
