LOCUS NC_001451 27608 bp ss-RNA linear VRL 13-AUG-2018
DEFINITION Avian infectious bronchitis virus, complete genome.
ACCESSION NC_001451
VERSION NC_001451.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Infectious bronchitis virus
ORGANISM Infectious bronchitis virus
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
Gammacoronavirus; Igacovirus; Avian coronavirus.
REFERENCE 1 (bases 529 to 20417)
AUTHORS Ziebuhr,J., Snijder,E.J. and Gorbalenya,A.E.
TITLE Virus-encoded proteinases and proteolytic processing in the
Nidovirales
JOURNAL J. Gen. Virol. 81 (Pt 4), 853-879 (2000)
PUBMED 10725411
REFERENCE 2 (bases 529 to 20417)
AUTHORS Brierley,I., Boursnell,M.E., Binns,M.M., Bilimoria,B., Blok,V.C.,
Brown,T.D. and Inglis,S.C.
TITLE An efficient ribosomal frame-shifting signal in the
polymerase-encoding region of the coronavirus IBV
JOURNAL EMBO J. 6 (12), 3779-3785 (1987)
PUBMED 3428275
REFERENCE 3 (bases 1 to 27608)
AUTHORS Boursnell,M.E., Brown,T.D., Foulds,I.J., Green,P.F., Tomley,F.M.
and Binns,M.M.
TITLE Completion of the sequence of the genome of the coronavirus avian
infectious bronchitis virus
JOURNAL J. Gen. Virol. 68 (Pt 1), 57-77 (1987)
PUBMED 3027249
REFERENCE 4 (sites)
AUTHORS Boursnell,M.E., Binns,M.M. and Brown,T.D.
TITLE Sequencing of coronavirus IBV genomic RNA: three open reading
frames in the 5' 'unique' region of mRNA D
JOURNAL J. Gen. Virol. 66 (Pt 10), 2253-2258 (1985)
PUBMED 2995560
REFERENCE 5 (sites)
AUTHORS Binns,M.M., Boursnell,M.E., Cavanagh,D., Pappin,D.J. and Brown,T.D.
TITLE Cloning and sequencing of the gene encoding the spike protein of
the coronavirus IBV
JOURNAL J. Gen. Virol. 66 (Pt 4), 719-726 (1985)
PUBMED 2984314
REFERENCE 6 (sites)
AUTHORS Boursnell,M.E., Binns,M.M., Foulds,I.J. and Brown,T.D.
TITLE Sequences of the nucleocapsid genes from two strains of avian
infectious bronchitis virus
JOURNAL J. Gen. Virol. 66 (Pt 3), 573-580 (1985)
PUBMED 2983001
REFERENCE 7 (sites)
AUTHORS Boursnell,M.E. and Brown,T.D.
TITLE Sequencing of coronavirus IBV genomic RNA: a 195-base open reading
frame encoded by mRNA B
JOURNAL Gene 29 (1-2), 87-92 (1984)
PUBMED 6092234
REFERENCE 8 (sites)
AUTHORS Boursnell,M.E., Brown,T.D. and Binns,M.M.
TITLE Sequence of the membrane protein gene from avian coronavirus IBV
JOURNAL Virus Res. 1 (4), 303-313 (1984)
PUBMED 6099661
REFERENCE 9 (bases 1 to 27608)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (09-SEP-2004) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from M95169.
Bases 25322-26092 are found in Gene 29, 87-92 (1984). These data
kindly submitted in computer readable form by: David Cavanagh
Molecular Biology Animal Health Institute Compton Nr.
Newbury, Berkshire RG16 ONNUK
Phone: 44 635 578411 x504
Email: cavanaghd@uk.ac.afrc.irad
Fax: 44 635 579003.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..27608
/organism="Infectious bronchitis virus"
/mol_type="genomic RNA"
/strain="Beaudette"
/db_xref="taxon:11120"
/lab_host="embryonated chicken eggs"
gene 529..20417
/gene="1ab"
/locus_tag="IBVgp1"
/note="translational frameshift on a slippery sequence
results in expression of orf1a and orf1b as a single
polyprotein 1ab"
/db_xref="GeneID:1489740"
CDS join(529..12354,12354..20417)
/gene="1ab"
/locus_tag="IBVgp1"
/experiment="experimental evidence, no additional details
recorded"
/note="frameshift product"
/codon_start=1
/product="ORF1ab polyprotein"
/protein_id="NP_066134.1"
/db_xref="GeneID:1489740"
/translation="MASSLKQGVSPKPRDVILVSKDIPEQLCDALFFYTSHNPKDYAD
AFAVRQKFDRSLQTGKQFKFETVCGLFLLKGVDKITPGVPAKVLKATSKLADLEDIFG
VSPLARKYRELLKTACQWSLTVEALDVRAQTLDEIFDPTEILWLQVAAKIHVSSMAMR
RLVGEVTAKVMDALGSNLSALFQIVKQQIARIFQKALAIFENVNELPQRIAALKMAFA
KCARSITVVVVERTLVVKEFAGTCLASINGAVAKFFEELPNGFMGSKIFTTLAFFKEA
AVRVVENIPNAPRGTKGFEVVGNAKGTQVVVRGMRNDLTLLDQKADIPVEPEGWSAIL
DGHLCYVFRSGDRFYAAPLSGNFALSDVHCCERVVCLSDGVTPEINDGLILAAIYSSF
SVSELVTALKKGEPFKFLGHKFVYAKDAAVSFTLAKAATIADVLRLFQSARVIAEDVW
SSFTEKSFEFWKLAYGKVRNLEEFVKTYVCKAQMSIVILAAVLGEDIWHLVSQVIYKL
GVLFTKVVDFCDKHWKGFCVQLKRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYKSF
KKCALGRIHGDLLFWKGGVHKIVQDGDEIWFDAIDSVDVEDLGVVQEKSIDFEVCDDV
TLPENQPGHMVQIEDDGKNYMFFRFKKDENIYYTPMSQLGAINVVCKAGGKTVTFGET
TVQEIPPPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVDTDLTVEQLLSVIYEKMCDD
LKLFPEAPEPPPFENVALVDKNGKDLDCIKSCHLIYRDYESDDDIEEEDAEECDTDSG
EAEECDTNSECEEEDEDTKVLALIQDPASIKYPLPLDEDYSVYNGCIVHKDALDVVNL
PSGEETFVVNNCFEGAVKPLPQKVVDVLGDWGEAVDAQEQLCQQEPLQHTFEEPVENS
TGSSKTMTEQVVVEDQELPVVEQDQDVVVYTPTDLEVAKETAEEVDEFILIFAVPKEE
VVSQKDGAQIKQEPIQVVKPQREKKAKKFKVKPATCEKPKFLEYKTCVGDLTVVIAKA
LDEFKEFCIVNAANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQRLVTPSFV
KGIQCVNNVVGPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVDFKMSIDA
MREAFEGCTIRVLLFSLSQEHIDYFDVTCKQKTIYLTEDGVKYRSIVLKPGDSLGQFG
QVYAKNKIVFTADDVEDKEILYVPTTDKSILEYYGLDAQKYVIYLQTLAQKWNVQYRD
NFLILEWRDGNCWISSAIVLLQAAKIRFKGFLTEAWAKLLGGDPTDFVAWCYASCTAK
VGDFSDANWLLANLAEHFDADYTNAFLKKRVSCNCGIKSYELRGLEACIQPVRATNLL
HFKTQYSNCPTCGANNTDEVIEASLPYLLLFATDGPATVDCDEDAVGTVVFVGSTNSG
HCYTQAAGQAFDNLAKDRKFGKKSPYITAMYTRFAFKNETSLPVAKQSKGKSKSVKED
VSNLATSSKASFDNLTDFEQWYDSNIYESLKVQESPDNFDKYVSFTTKEDSKLPLTLK
VRGIKSVVDFRSKDGFIYKLTPDTDENSKAPVYYPVLDAISLKAIWVEGNANFVVGHP
NYYSKSLHIPTFWENAENFVKMGDKIGGVTMGLWRAEHLNKPNLERIFNIAKKAIVGS
SVVTTQCGKLIGKAATFIADKVGGGVVRNITDSIKGLCGITRGHFERKMSPQFLKTLM
FFLFYFLKASVKSVVASYKTVLCKVVLATLLIVWFVYTSNPVMFTGIRVLDFLFEGSL
CGPYKDYGKDSFDVLRYCADDFICRVCLHDKDSLHLYKHAYSVEQVYKDAASGFIFNW
NWLYLVFLILFVKPVAGFVIICYCVKYLVLNSTVLQTGVCFLDWFVQTVFSHFNFMGA
GFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSGY
NFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDF
VNLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHA
LEEAKNAAIYYAQYLCKPILILDQALYEQLVVEPVSKSVIDKVCSILSSIISVDTAAL
NYKAGTLRDALLSITKDEEAVDMAIFCHNHDVDYTGDGFTNVIPSYGIDTGKLTPRDR
GFLINADASIANLRVKNAPPVVWKFSELIKLSDSCLKYLISATVKSGVRFFITKSGAK
QVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTACCSGYYYMEVSKSFV
HPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFWGRPYDNSRNCPIVT
AVIDGDGTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFNREIVGYTQDSIITE
GSFYTSIALFSARCLYLTASNTPQLYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLI
VPQQILHTPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFNDEYTSKPGVFCGST
VRELMFSMVSTFFTGVNPNIYMQLATMFLILVVVVLIFAMVIKFQGVFKAYATTVFIT
MLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLVFTFGLIVPTW
LACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVIRGSEFVKL
TNEIGDKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSGVEIVYTPPR
YSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHVLGKFSGD
QWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKYKFIKANCG
DSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLEL
PNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSLPKW
LESTTVSVDDYNKWAGDNGFTPFSTSTAITKLSAITGVDVCKLLRTIMVKNSQWGGDP
ILGQYNFEDELTPESVFNQIGGVRLQSSFVRKATSWFWSRCVLACFLFVLCAIVLFTA
VPLKFYVYAAVILLMAVLFISFTVKHVMAYMDTFLLPTLITVIIGVCAEVPFIYNTLI
SQVVIFLSQWYDPVVFDTMVPWMFLPLVLYTAFKCVQGCYMNSFNTSLLMLYQFVKLG
FVIYTSSNTLTAYTEGNWELFFELVHTTVLANVSSNSLIGLFVFKCAKWMLYYCNATY
LNNYVLMAVMVNCIGWLCTCYFGLYWWVNKVFGLTLGKYNFKVSVDQYRYMCLHKINP
PKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSDVKCTTVVLMQLLTKLNVEANSKMH
VYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLSEYCDDILKRSTVLQSVTQ
EFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAANIAKSVFDRDLAVQKK
LDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVP
LATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDADGTELHPTSTGS
GLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTKACVAGVDQAHCSVE
SKCYYTNISGNSVVAAITSSNPNLKVASFLNEAGNQIYVDLDPPCKFGMKVGVKVEVV
YLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDPADTYCKY
VAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPGSVG
NLDGRCQFKGSFVQIPTTEKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKSSVQSV
AGASDFDKNYLNRVRGSSEARLIPLASGCDPDVVKRAFDVCNKESAGMFQNLKRNCAR
FQELRDTEDGNLEYLDSYFVVKQTTPSNYEHEKSCYEDLKSEVTADHDFFVFNKNIYN
ISRQRLTKYTMMDFCYALRHFDPKDCEVLKEILVTYGCIEDYHPKWFEENKDWYDPIE
NSKYYVMLAKMGPIVRRALLNAIEFGNLMVEKGYVGVITLDNQDLNGKFYDFGDFQKT
APGAGVPVFDTYYSYMMPIIAMTDALAPERYFEYDVHKGYKSYDLLKYDYTEEKQELF
QKYFKYWDQEYHPNCRDCSDDRCLIHCANFNILFSTLIPQTSFGNLCRKVFVDGVPFI
ATCGYHSKELGVIMNQDNTMSFSKMGLSQLMQFVGDPALLVGTSNNLVDLRTSCFSVC
ALTSGITHQTVKPGHFNKDFYDFAEKAGMFKEGSSIPLKHFFYPQTGNAAINDYDYYR
YNRPTMFDICQLLFCLEVTSKYFECYEGGCIPASQVVVNNLDKSAGYPFNKFGKARLY
YEMSLEEQDQLFEITKKNVLPTITQMNLKYAISAKNRARTVAGVSILSTMTNRQFHQK
ILKSIVNTRNASVVIGTTKFYGGWDNMLRNLIQGVEDPILMGWDYPKCDRAMPNLLRI
AASLVLARKHTNCCSWSERIYRLYNECAQVLSETVLATGGIYVKPGGTSSGDATTAYA
NSVFNIIQATSANVARLLSVITRDIVYDNIKSLQYELYQQVYRRVNFDPAFVEKFYSY
LCKNFSLMILSDDGVVCYNNTLAKQGLVADISGFREVLYYQNNVFMADSKCWVEPDLE
KGPHEFCSQHTMLVEVDGEPKYLPYPDPSRILGACVFVDDVDKTEPVAVMERYIALAI
DAYPLVHHENEEYKKVFFVLLAYIRKLYQELSQNMLMDYSFVMDIDKGSKFWEQEFYE
NMYRAPTTLQSCGVCVVCNSQTILRCGNCIRKPFLCCKCCYDHVMHTDHKNVLSINPY
ICSQLGCGEADVTKLYLGGMSYFCGNHKPKLSIPLVSNGTVFGIYRANCAGSENVDDF
NQLATTNWSIVEPYILANRCSDSLRRFAAETVKATEELHKQQFASAEVREVFSDRELI
LSWEPGKTRPPLNRNYVFTGYHFTRTSKVQLGDFTFEKGEGKDVVYYKATSTAKLSVG
DIFVLTSHNVVSLVAPTLCPQQTFSRFVNLRPNVMVPECFVNNIPLYHLVGKQKRTTV
QGPPGSGKSHFAIGLAVYFSSARVVFTACSHAAVDALCEKAFKFLKVDDCTRIVPQRT
TVDCFSKFKANDTGKKYIFSTINALPEVSCDILLVDEVSMLTNYELSFINGKINYQYV
VYVGDPAQLPAPRTLLNGSLSPKDYNVVTNLMVCVKPDIFLAKCYRCPKEIVDTVSTL
VYDGKFIANNPESRECFKVIVNNGNSDVGHESGSAYNTTQLEFVKDFVCRNKQWREAI
FISPYNAMNQRAYRMLGLNVQTVDSSQGSEYDYVIFCVTADSQHALNINRFNVALTRA
KRGILVVMRQRDELYSALKFTELDSETSLQGTGLFKICNKEFSGVHPAYAVTTKALAA
TYKVNDELAALVNVEAGSEITYKHLISLLGFKMSVNVEGCHNMFITRDEAIRNVRGWV
GFDVEATHACGTNIGTNLPFQVGFSTGADFVVTPEGLVDTSIGNNFEPVNSKAPPGEQ
FNHLRVLFKSAKPWHVIRPRIVQMLADNLCNVSDCVVFVTWCHGLELTTLRYFVKIGK
EQVCSCGSRATTFNSHTQAYACWKHCLGFDFVYNPLLVDIQQWGYSGNLQFNHDLHCN
VHGHAHVASVDAIMTRCLAINNAFCQDVNWDLTYPHIANEDEVNSSCRYLQRMYLNAC
VDALKVNVVYDIGNPKGIKCVRRGDVNFRFYDKNPIVRNVKQFEYDYNQHKDKFADGL
CMFWNCNVDCYPDNSLVCRYDTRNLSVFNLPGCNGGSLYVNKHAFYTPKFDRISFRNL
KAMPFFFYDSSPCETIQVDGVAQDLVSLATKDCITKCNIGGAVCKKHAQMYAEFVTSY
NAAVTAGFTFWVTNKLNPYNLWKSFSALQSIDNIAYNMYKGGHYDAIAGEMPTVITGD
KVFVIDQGVEKAVFVNQTTLPTSVAFELYAKRNIRTLPNNRILKGLGVDVTNGFVIWD
YANQTPLYRNTVKVCAYTDIEPNGLVVLYDDRYGDYQSFLAADNAVLVSTQCYKRYSY
VEIPSNLLVQNGMPLKDGANLYVYKRVNGAFVTLPNTINTQGRSYETFEPRSDIERDF
LAMSEESFVERYGKDLGLQHILYGEVDKPQLGGLHTVIGMYRLLRANKLNAKSVTNSD
SDVMQNYFVLSDNGSYKQVCTVVDLLLDDFLELLRNILKEYGTNKSKVVTVSIDYHSI
NFMTWFEDGSIKTCYPQLQSAWTCGYNMPELYKVQNCVMEPCNIPNYGVGITLPSGIL
MNVAKYTQLCQYLSKTTICVPHNMRVMHFGAGSDKGVAPGSTVLKQWLPEGTLLVDND
IVDYVSDAHVSVLSDCNKYNTEHKFDLVISDMYTDNDSKRKHEGVIANNGNDDVFIYL
SSFLRNNLALGGSFAVKVTETSWHEVLYDIAQDCAWWTMFCTAVNASSSEAFLIGVNY
LGASEKVKVSGKTLHANYIFWRNCNYLQTSAYSIFDVAKFDLRLKATPVVNLKTEQKT
DLVFNLIKCGKLLVRDVGNTSFTSDSFVCTM"
mat_peptide 529..2547
/gene="1ab"
/locus_tag="IBVgp1"
/product="leader protein p87"
/experiment="experimental evidence, no additional details
recorded"
/protein_id="NP_740634.1"
misc_feature 568..1641
/gene="1ab"
/locus_tag="IBVgp1"
/note="Replicase polyprotein 1a N-terminal domain; Region:
Nsp2a_N; pfam17896"
/db_xref="CDD:375411"
mat_peptide 2548..8865
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp1 (HD1)"
/note="hydrophobic domain 1"
/protein_id="NP_740622.1"
misc_feature 2608..2859
/gene="1ab"
/locus_tag="IBVgp1"
/note="first ubiquitin-like (Ubl) domain located at the
N-terminus of coronavirus SARS-CoV non-structural protein
3 (Nsp3) and related proteins; Region:
Ubl1_cv_Nsp3_N-like; cl28922"
/db_xref="CDD:452900"
misc_feature 3634..4014
/gene="1ab"
/locus_tag="IBVgp1"
/note="X-domain (or Mac1 domain) of viral non-structural
protein 3 and related macrodomains; Region:
Macro_X_Nsp3-like; cd21557"
/db_xref="CDD:438957"
misc_feature order(3652..3660,3670..3690,3913..3918,3922..3936,
4009..4011)
/gene="1ab"
/locus_tag="IBVgp1"
/note="ADP-ribose binding site [chemical binding]; other
site"
/db_xref="CDD:438957"
misc_feature 4048..4959
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus papain-like protease; Region:
gammaCoV_PLPro; cd21733"
/db_xref="CDD:409650"
misc_feature order(4258..4260,4333..4335,4342..4353,4498..4506,
4510..4515,4522..4527,4621..4626,4639..4641,4678..4686,
4690..4692,4753..4758,4762..4767,4813..4815,4834..4839,
4915..4917)
/gene="1ab"
/locus_tag="IBVgp1"
/note="ubiquitin binding site [polypeptide binding]; other
site"
/db_xref="CDD:409650"
misc_feature order(4498..4506,4765..4770,4813..4815,4822..4824,
4840..4842,4915..4917)
/gene="1ab"
/locus_tag="IBVgp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:409650"
misc_feature 5749..7323
/gene="1ab"
/locus_tag="IBVgp1"
/note="C-terminus of gammacoronavirus non-structural
protein 3, including transmembrane and Y domains; Region:
TM_Y_gammaCoV_Nsp3_C; cd21710"
/db_xref="CDD:409658"
misc_feature 5749..5814
/gene="1ab"
/locus_tag="IBVgp1"
/note="TM1 [structural motif]; Region: TM1"
/db_xref="CDD:409658"
misc_feature 6058..6126
/gene="1ab"
/locus_tag="IBVgp1"
/note="TM2 [structural motif]; Region: TM2"
/db_xref="CDD:409658"
misc_feature 7363..8544
/gene="1ab"
/locus_tag="IBVgp1"
/note="coronavirus non-structural protein 4 (Nsp4)
transmembrane domain; Region: cv_Nsp4_TM; cd21473"
/db_xref="CDD:394836"
misc_feature 7363..7431
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative TM helix 1 [structural motif]; Region:
putative TM helix 1"
/db_xref="CDD:394836"
misc_feature 8200..8265
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative TM helix 2 [structural motif]; Region:
putative TM helix 2"
/db_xref="CDD:394836"
misc_feature 8308..8373
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative TM helix 3 [structural motif]; Region:
putative TM helix 3"
/db_xref="CDD:394836"
misc_feature 8452..8520
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative TM helix 4 [structural motif]; Region:
putative TM helix 4"
/db_xref="CDD:394836"
misc_feature 8587..8856
/gene="1ab"
/locus_tag="IBVgp1"
/note="Coronavirus nonstructural protein 4 C-terminus;
Region: Corona_NSP4_C; pfam16348"
/db_xref="CDD:406690"
mat_peptide 8866..9786
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp2 (3CL-Pro)"
/protein_id="NP_740623.1"
misc_feature 8869..9786
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 5, also
called Main protease (Mpro); Region: gammaCoV_Nsp5_Mpro;
cd21667"
/db_xref="CDD:394888"
misc_feature order(8869..8871,8875..8877,8881..8898,8905..8907,
9223..9240,9268..9282,9355..9369,9715..9717,9721..9726,
9760..9765)
/gene="1ab"
/locus_tag="IBVgp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:394888"
misc_feature order(8938..8946,8986..8988,9277..9294,9346..9357,
9373..9375,9418..9435)
/gene="1ab"
/locus_tag="IBVgp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:394888"
misc_feature 9748..10665
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 6; Region:
gammaCoV-Nsp6; cd21559"
/db_xref="CDD:394845"
mat_peptide 9787..10665
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp3 (HD2)"
/note="hydrophobic domain 2"
/protein_id="NP_740624.1"
mat_peptide 10666..10914
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp4"
/protein_id="NP_740625.1"
misc_feature 10666..10914
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 7; Region:
gammaCoV_Nsp7; cd21828"
/db_xref="CDD:409254"
misc_feature order(10669..10671,10678..10689,10696..10704,10708..10713,
10720..10722,10747..10749,10756..10758,10774..10776,
10810..10827,10831..10848,10867..10881)
/gene="1ab"
/locus_tag="IBVgp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409254"
mat_peptide 10915..11544
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp5"
/protein_id="NP_740626.1"
misc_feature 10915..11544
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 8; Region:
gammaCoV_Nsp8; cd21832"
/db_xref="CDD:409259"
misc_feature order(10924..10932,10939..10944,10948..10953,10963..10965,
10981..10986,11116..11118,11125..11127,11134..11139,
11161..11166,11173..11178,11182..11190,11194..11202,
11206..11226,11230..11238,11242..11247,11254..11259,
11263..11265,11269..11274,11281..11292,11371..11373)
/gene="1ab"
/locus_tag="IBVgp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409259"
misc_feature 11539..11877
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 9; Region:
gammaCoV_Nsp9; cd21899"
/db_xref="CDD:409332"
mat_peptide 11545..11877
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp6"
/protein_id="NP_740627.1"
misc_feature 11545..11562
/gene="1ab"
/locus_tag="IBVgp1"
/note="N-finger; other site"
/db_xref="CDD:409332"
misc_feature order(11551..11559,11563..11568,11755..11763,11806..11808,
11824..11829,11833..11841,11845..11853,11857..11862)
/gene="1ab"
/locus_tag="IBVgp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409332"
mat_peptide 11878..12312
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp7 (GLF)"
/note="growth factor-like protein"
/protein_id="NP_740628.1"
misc_feature 11881..12282
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 10; Region:
gammaCoV_Nsp10; cd21902"
/db_xref="CDD:409327"
misc_feature order(11881..11904,11914..11916,11920..11928,11932..11940,
11953..11958,11965..11970,11977..11979,11998..12015,
12052..12057,12085..12087,12091..12096,12106..12108,
12112..12129,12154..12162,12169..12180)
/gene="1ab"
/locus_tag="IBVgp1"
/note="Nsp14 interface [polypeptide binding]; other site"
/db_xref="CDD:409327"
misc_feature order(11920..11928,11932..11940,11953..11955,11998..12000,
12004..12015,12052..12060,12112..12123,12130..12132,
12175..12180,12232..12234)
/gene="1ab"
/locus_tag="IBVgp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409327"
misc_feature order(11953..11955,12004..12015,12052..12060,12130..12132,
12175..12180,12232..12234)
/gene="1ab"
/locus_tag="IBVgp1"
/note="homotrimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409327"
misc_feature order(11998..12021,12052..12057,12085..12096,12109..12114,
12118..12120,12169..12180)
/gene="1ab"
/locus_tag="IBVgp1"
/note="Nsp16 interface [polypeptide binding]; other site"
/db_xref="CDD:409327"
mat_peptide join(12313..12354,12354..15131)
/gene="1ab"
/locus_tag="IBVgp1"
/product="RNA-dependent RNA polymerase"
/note="coronavirus nsp9 (RdRp)"
/protein_id="NP_740629.1"
misc_feature join(12340..12354,12354..15131)
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus RNA-dependent RNA polymerase, also
known as non-structural protein 12: responsible for
replication and transcription of the viral RNA genome;
Region: gammaCoV_RdRp; cd21587"
/db_xref="CDD:394891"
misc_feature order(13143..13157,13305..13310,13314..13316,13320..13334,
13350..13361,13368..13370,13440..13442,13449..13454,
13458..13463,13470..13472,13476..13490,13494..13514,
13524..13526,13530..13532,13542..13547,13557..13559,
13851..13856,13863..13865,13878..13883,13887..13889,
13893..13904,14331..14333)
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative Nsp8 interaction site [polypeptide
binding]; other site"
/db_xref="CDD:394891"
misc_feature order(13563..13577,13581..13583,13596..13598,13623..13625,
13629..13631,13656..13673,13983..13985,13989..13991,
14862..14864)
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative Nsp7 interaction site [polypeptide
binding]; other site"
/db_xref="CDD:394891"
misc_feature order(13830..13832,13836..13844,13968..13970,14004..14006,
14010..14012,14028..14030,14040..14042,14052..14054,
14064..14066,14103..14105,14109..14111,14115..14117,
14379..14390,14397..14399,14607..14618,14772..14777,
14829..14831,14853..14855,14904..14909,14919..14921,
14925..14930)
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative RNA binding site [nucleotide binding];
other site"
/db_xref="CDD:394891"
misc_feature 13836..13877
/gene="1ab"
/locus_tag="IBVgp1"
/note="conserved polymerase motif G; other site"
/db_xref="CDD:394891"
misc_feature 13947..14015
/gene="1ab"
/locus_tag="IBVgp1"
/note="conserved polymerase motif F; other site"
/db_xref="CDD:394891"
misc_feature order(13980..13982,14373..14381,14394..14396,14406..14408,
14610..14612)
/gene="1ab"
/locus_tag="IBVgp1"
/note="inhibitor binding site [chemical binding];
inhibition site"
/db_xref="CDD:394891"
misc_feature 14166..14216
/gene="1ab"
/locus_tag="IBVgp1"
/note="conserved polymerase motif A; other site"
/db_xref="CDD:394891"
misc_feature 14373..14462
/gene="1ab"
/locus_tag="IBVgp1"
/note="conserved polymerase motif B; other site"
/db_xref="CDD:394891"
misc_feature 14592..14636
/gene="1ab"
/locus_tag="IBVgp1"
/note="conserved polymerase motif C; other site"
/db_xref="CDD:394891"
misc_feature 14658..14723
/gene="1ab"
/locus_tag="IBVgp1"
/note="conserved polymerase motif D; other site"
/db_xref="CDD:394891"
misc_feature 14763..14798
/gene="1ab"
/locus_tag="IBVgp1"
/note="conserved polymerase motif E; other site"
/db_xref="CDD:394891"
mat_peptide 15132..16931
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp10"
/note="metal-binding NTPase/helicase"
/protein_id="NP_740630.1"
misc_feature 15132..15416
/gene="1ab"
/locus_tag="IBVgp1"
/note="Cys/His rich zinc-binding domain (CH/ZBD) of
coronavirus SARS NSP13 helicase and related proteins;
Region: ZBD_cv_Nsp13-like; cd21401"
/db_xref="CDD:439168"
misc_feature order(15264..15266,15327..15329,15333..15335,15372..15374,
15399..15413)
/gene="1ab"
/locus_tag="IBVgp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:439168"
misc_feature 15426..15569
/gene="1ab"
/locus_tag="IBVgp1"
/note="stalk domain of coronavirus Nsp13 helicase and
related proteins; Region: stalk_CoV_Nsp13-like; cd21689"
/db_xref="CDD:410205"
misc_feature order(15435..15437,15522..15524)
/gene="1ab"
/locus_tag="IBVgp1"
/note="key interaction residues; other site"
/db_xref="CDD:410205"
misc_feature 15579..15815
/gene="1ab"
/locus_tag="IBVgp1"
/note="1B domain of coronavirus SARS NSP13 helicase and
related proteins; Region: 1B_cv_Nsp13-like; cd21409"
/db_xref="CDD:394817"
misc_feature order(15663..15668,15672..15674,15765..15767)
/gene="1ab"
/locus_tag="IBVgp1"
/note="nucleic acid substrate binding site [nucleotide
binding]; other site"
/db_xref="CDD:394817"
misc_feature 15777..15785
/gene="1ab"
/locus_tag="IBVgp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:394817"
misc_feature 15882..16910
/gene="1ab"
/locus_tag="IBVgp1"
/note="helicase domain of gammacoronavirus non-structural
protein 13; Region: gammaCoV_Nsp13-helicase; cd21720"
/db_xref="CDD:409653"
misc_feature order(15984..16001,16341..16343,16455..16457,16749..16751,
16755..16757,16836..16838)
/gene="1ab"
/locus_tag="IBVgp1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:409653"
misc_feature order(15993..15998,16251..16256,16341..16343,16836..16838)
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative active site [active]"
/db_xref="CDD:409653"
mat_peptide 16932..18494
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp11"
/protein_id="NP_740631.1"
misc_feature 16935..18488
/gene="1ab"
/locus_tag="IBVgp1"
/note="nonstructural protein 14 of gammacoronavirus;
Region: gammaCoV_Nsp14; cd21658"
/db_xref="CDD:394957"
misc_feature order(16935..16937,16941..16952,16977..17006,17079..17081,
17091..17093,17106..17129,17229..17234,17298..17300,
17304..17306,17316..17321,17502..17504,17511..17516,
17523..17531,17574..17576)
/gene="1ab"
/locus_tag="IBVgp1"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:394957"
misc_feature order(17196..17198,17202..17204,17499..17501,17727..17729,
17742..17744)
/gene="1ab"
/locus_tag="IBVgp1"
/note="ExoN active site [active]"
/db_xref="CDD:394957"
misc_feature order(17799..17801,17841..17843,17850..17855,17862..17864,
17922..17933,17937..17939,17979..17987,18012..18020,
18069..18083,18117..18119,18174..18176,18180..18185,
18192..18194,18198..18200,18429..18431)
/gene="1ab"
/locus_tag="IBVgp1"
/note="N7-MTase active site [active]"
/db_xref="CDD:394957"
mat_peptide 18495..19508
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp12"
/protein_id="NP_740632.1"
misc_feature 18498..18677
/gene="1ab"
/locus_tag="IBVgp1"
/note="N-terminal domain of gammacoronavirus Nonstructural
protein 15 (Nsp15), and related proteins; Region:
NTD_gammaCoV_Nsp15-like; cd22650"
/db_xref="CDD:439165"
misc_feature order(18498..18503,18555..18557,18561..18572,18594..18596,
18609..18611,18636..18638,18642..18653)
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative hexamer interface [polypeptide binding];
other site"
/db_xref="CDD:439165"
misc_feature order(18519..18527,18531..18536,18573..18584,18588..18590,
18597..18599,18603..18620,18627..18638,18675..18677)
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative trimer interface [polypeptide binding];
other site"
/db_xref="CDD:439165"
misc_feature 18687..19052
/gene="1ab"
/locus_tag="IBVgp1"
/note="middle domain of gammacoronavirus Nonstructural
protein 15 (Nsp15), and related proteins; Region:
M_gcv_Nsp15-like; cd21168"
/db_xref="CDD:394906"
misc_feature 19047..19502
/gene="1ab"
/locus_tag="IBVgp1"
/note="Nidoviral uridylate-specific endoribonuclease
(NendoU) domain of coronavirus Nonstructural Protein 15
(Nsp15) and related proteins; Region:
NendoU_cv_Nsp15-like; cd21161"
/db_xref="CDD:439158"
misc_feature order(19068..19070,19074..19076,19179..19187,19251..19253,
19263..19268,19272..19274,19293..19295,19299..19301,
19305..19307,19314..19319,19323..19325)
/gene="1ab"
/locus_tag="IBVgp1"
/note="trimer interface [polypeptide binding]; other site"
/db_xref="CDD:439158"
misc_feature order(19161..19163,19173..19175,19197..19202,19206..19208,
19326..19328,19335..19340,19488..19490,19494..19496)
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative active site [active]"
/db_xref="CDD:439158"
mat_peptide 19509..20414
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp13"
/protein_id="NP_740633.1"
misc_feature 19509..20408
/gene="1ab"
/locus_tag="IBVgp1"
/note="Coronavirus NSP13; Region: NSP13; pfam06460"
/db_xref="CDD:399456"
CDS 529..12384
/gene="1ab"
/locus_tag="IBVgp1"
/note="ORF for gene 1; label: 1a"
/codon_start=1
/product="ORF1a polyprotein"
/protein_id="NP_040829.1"
/db_xref="GeneID:1489740"
/translation="MASSLKQGVSPKPRDVILVSKDIPEQLCDALFFYTSHNPKDYAD
AFAVRQKFDRSLQTGKQFKFETVCGLFLLKGVDKITPGVPAKVLKATSKLADLEDIFG
VSPLARKYRELLKTACQWSLTVEALDVRAQTLDEIFDPTEILWLQVAAKIHVSSMAMR
RLVGEVTAKVMDALGSNLSALFQIVKQQIARIFQKALAIFENVNELPQRIAALKMAFA
KCARSITVVVVERTLVVKEFAGTCLASINGAVAKFFEELPNGFMGSKIFTTLAFFKEA
AVRVVENIPNAPRGTKGFEVVGNAKGTQVVVRGMRNDLTLLDQKADIPVEPEGWSAIL
DGHLCYVFRSGDRFYAAPLSGNFALSDVHCCERVVCLSDGVTPEINDGLILAAIYSSF
SVSELVTALKKGEPFKFLGHKFVYAKDAAVSFTLAKAATIADVLRLFQSARVIAEDVW
SSFTEKSFEFWKLAYGKVRNLEEFVKTYVCKAQMSIVILAAVLGEDIWHLVSQVIYKL
GVLFTKVVDFCDKHWKGFCVQLKRAKLIVTETFCVLKGVAQHCFQLLLDAIHSLYKSF
KKCALGRIHGDLLFWKGGVHKIVQDGDEIWFDAIDSVDVEDLGVVQEKSIDFEVCDDV
TLPENQPGHMVQIEDDGKNYMFFRFKKDENIYYTPMSQLGAINVVCKAGGKTVTFGET
TVQEIPPPDVVPIKVSIECCGEPWNTIFKKAYKEPIEVDTDLTVEQLLSVIYEKMCDD
LKLFPEAPEPPPFENVALVDKNGKDLDCIKSCHLIYRDYESDDDIEEEDAEECDTDSG
EAEECDTNSECEEEDEDTKVLALIQDPASIKYPLPLDEDYSVYNGCIVHKDALDVVNL
PSGEETFVVNNCFEGAVKPLPQKVVDVLGDWGEAVDAQEQLCQQEPLQHTFEEPVENS
TGSSKTMTEQVVVEDQELPVVEQDQDVVVYTPTDLEVAKETAEEVDEFILIFAVPKEE
VVSQKDGAQIKQEPIQVVKPQREKKAKKFKVKPATCEKPKFLEYKTCVGDLTVVIAKA
LDEFKEFCIVNAANEHMTHGSGVAKAIADFCGLDFVEYCEDYVKKHGPQQRLVTPSFV
KGIQCVNNVVGPRHGDNNLHEKLVAAYKNVLVDGVVNYVVPVLSLGIFGVDFKMSIDA
MREAFEGCTIRVLLFSLSQEHIDYFDVTCKQKTIYLTEDGVKYRSIVLKPGDSLGQFG
QVYAKNKIVFTADDVEDKEILYVPTTDKSILEYYGLDAQKYVIYLQTLAQKWNVQYRD
NFLILEWRDGNCWISSAIVLLQAAKIRFKGFLTEAWAKLLGGDPTDFVAWCYASCTAK
VGDFSDANWLLANLAEHFDADYTNAFLKKRVSCNCGIKSYELRGLEACIQPVRATNLL
HFKTQYSNCPTCGANNTDEVIEASLPYLLLFATDGPATVDCDEDAVGTVVFVGSTNSG
HCYTQAAGQAFDNLAKDRKFGKKSPYITAMYTRFAFKNETSLPVAKQSKGKSKSVKED
VSNLATSSKASFDNLTDFEQWYDSNIYESLKVQESPDNFDKYVSFTTKEDSKLPLTLK
VRGIKSVVDFRSKDGFIYKLTPDTDENSKAPVYYPVLDAISLKAIWVEGNANFVVGHP
NYYSKSLHIPTFWENAENFVKMGDKIGGVTMGLWRAEHLNKPNLERIFNIAKKAIVGS
SVVTTQCGKLIGKAATFIADKVGGGVVRNITDSIKGLCGITRGHFERKMSPQFLKTLM
FFLFYFLKASVKSVVASYKTVLCKVVLATLLIVWFVYTSNPVMFTGIRVLDFLFEGSL
CGPYKDYGKDSFDVLRYCADDFICRVCLHDKDSLHLYKHAYSVEQVYKDAASGFIFNW
NWLYLVFLILFVKPVAGFVIICYCVKYLVLNSTVLQTGVCFLDWFVQTVFSHFNFMGA
GFYFWLFYKIYIQVHHILYCKDVTCEVCKRVARSNRQEVSVVVGGRKQIVHVYTNSGY
NFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYHVVDEACLVDDF
VNLKYKAATPGKDSASSAVKCFSVTDFLKKAVFLKEALKCEQISNDGFIVCNTQSAHA
LEEAKNAAIYYAQYLCKPILILDQALYEQLVVEPVSKSVIDKVCSILSSIISVDTAAL
NYKAGTLRDALLSITKDEEAVDMAIFCHNHDVDYTGDGFTNVIPSYGIDTGKLTPRDR
GFLINADASIANLRVKNAPPVVWKFSELIKLSDSCLKYLISATVKSGVRFFITKSGAK
QVIACHTQKLLVEKKAGGIVSGTFKCFKSYFKWLLIFYILFTACCSGYYYMEVSKSFV
HPMYDVNSTLHVEGFKVIDKGVLREIVPEDTCFSNKFVNFDAFWGRPYDNSRNCPIVT
AVIDGDGTVATGVPGFVSWVMDGVMFIHMTQTERKPWYIPTWFNREIVGYTQDSIITE
GSFYTSIALFSARCLYLTASNTPQLYCFNGDNDAPGALPFGSIIPHRVYFQPNGVRLI
VPQQILHTPYVVKFVSDSYCRGSVCEYTRPGYCVSLNPQWVLFNDEYTSKPGVFCGST
VRELMFSMVSTFFTGVNPNIYMQLATMFLILVVVVLIFAMVIKFQGVFKAYATTVFIT
MLVWVINAFILCVHSYNSVLAVILLVLYCYASLVTSRNTVIIMHCWLVFTFGLIVPTW
LACCYLGFIIYMYTPLFLWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVIRGSEFVKL
TNEIGDKFEAYLSAYARLKYYSGTGSEQDYLQACRAWLAYALDQYRNSGVEIVYTPPR
YSIGVSRLQSGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHVLGKFSGD
QWNDVLNLANNHEFEVTTQHGVTLNVVSRRLKGAVLILQTAVANAETPKYKFIKANCG
DSFTIACAYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLEL
PNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSLPKW
LESTTVSVDDYNKWAGDNGFTPFSTSTAITKLSAITGVDVCKLLRTIMVKNSQWGGDP
ILGQYNFEDELTPESVFNQIGGVRLQSSFVRKATSWFWSRCVLACFLFVLCAIVLFTA
VPLKFYVYAAVILLMAVLFISFTVKHVMAYMDTFLLPTLITVIIGVCAEVPFIYNTLI
SQVVIFLSQWYDPVVFDTMVPWMFLPLVLYTAFKCVQGCYMNSFNTSLLMLYQFVKLG
FVIYTSSNTLTAYTEGNWELFFELVHTTVLANVSSNSLIGLFVFKCAKWMLYYCNATY
LNNYVLMAVMVNCIGWLCTCYFGLYWWVNKVFGLTLGKYNFKVSVDQYRYMCLHKINP
PKTVWEVFSTNILIQGIGGDRVLPIATVQAKLSDVKCTTVVLMQLLTKLNVEANSKMH
VYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLSEYCDDILKRSTVLQSVTQ
EFSHIPSYAEYERAKNLYEKVLVDSKNGGVTQQELAAYRKAANIAKSVFDRDLAVQKK
LDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQASSGVVP
LATVPIVCSNKLTLVIPDPETWVKCVEGVHVTYSTVVWNIDTVIDADGTELHPTSTGS
GLTYCISGANIAWPLKVNLTRNGHNKVDVVLQNNELMPHGVKTKACVAGVDQAHCSVE
SKCYYTNISGNSVVAAITSSNPNLKVASFLNEAGNQIYVDLDPPCKFGMKVGVKVEVV
YLYFIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDPADTYCKY
VAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGASVCLYCRAHIAHPGSVG
NLDGRCQFKGSFVQIPTTEKDPVGFCLRNKVCTVCQCWIGYGCQCDSLRQPKSSVQSV
AGASDFDKNYLNGYGVAVRLG"
misc_feature 568..1641
/gene="1ab"
/locus_tag="IBVgp1"
/note="gamma- and deltacoronavirus non-structural protein
2 (Nsp2), similar to IBV Nsp2 and related proteins;
Region: cv_gamma-delta_Nsp2_IBV-like; cl40697"
/db_xref="CDD:424328"
misc_feature 2608..2859
/gene="1ab"
/locus_tag="IBVgp1"
/note="first ubiquitin-like (Ubl) domain located at the
N-terminus of coronavirus SARS-CoV non-structural protein
3 (Nsp3) and related proteins; Region:
Ubl1_cv_Nsp3_N-like; cl28922"
/db_xref="CDD:452900"
misc_feature 3634..4014
/gene="1ab"
/locus_tag="IBVgp1"
/note="X-domain (or Mac1 domain) of viral non-structural
protein 3 and related macrodomains; Region:
Macro_X_Nsp3-like; cd21557"
/db_xref="CDD:438957"
misc_feature order(3652..3660,3670..3690,3913..3918,3922..3936,
4009..4011)
/gene="1ab"
/locus_tag="IBVgp1"
/note="ADP-ribose binding site [chemical binding]; other
site"
/db_xref="CDD:438957"
misc_feature 4048..4959
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus papain-like protease; Region:
gammaCoV_PLPro; cd21733"
/db_xref="CDD:409650"
misc_feature order(4258..4260,4333..4335,4342..4353,4498..4506,
4510..4515,4522..4527,4621..4626,4639..4641,4678..4686,
4690..4692,4753..4758,4762..4767,4813..4815,4834..4839,
4915..4917)
/gene="1ab"
/locus_tag="IBVgp1"
/note="ubiquitin binding site [polypeptide binding]; other
site"
/db_xref="CDD:409650"
misc_feature order(4498..4506,4765..4770,4813..4815,4822..4824,
4840..4842,4915..4917)
/gene="1ab"
/locus_tag="IBVgp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:409650"
misc_feature 5749..7323
/gene="1ab"
/locus_tag="IBVgp1"
/note="C-terminus of gammacoronavirus non-structural
protein 3, including transmembrane and Y domains; Region:
TM_Y_gammaCoV_Nsp3_C; cd21710"
/db_xref="CDD:409658"
misc_feature 5749..5814
/gene="1ab"
/locus_tag="IBVgp1"
/note="TM1 [structural motif]; Region: TM1"
/db_xref="CDD:409658"
misc_feature 6058..6126
/gene="1ab"
/locus_tag="IBVgp1"
/note="TM2 [structural motif]; Region: TM2"
/db_xref="CDD:409658"
misc_feature 7363..8544
/gene="1ab"
/locus_tag="IBVgp1"
/note="coronavirus non-structural protein 4 (Nsp4)
transmembrane domain; Region: cv_Nsp4_TM; cd21473"
/db_xref="CDD:394836"
misc_feature 7363..7431
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative TM helix 1 [structural motif]; Region:
putative TM helix 1"
/db_xref="CDD:394836"
misc_feature 8200..8265
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative TM helix 2 [structural motif]; Region:
putative TM helix 2"
/db_xref="CDD:394836"
misc_feature 8308..8373
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative TM helix 3 [structural motif]; Region:
putative TM helix 3"
/db_xref="CDD:394836"
misc_feature 8452..8520
/gene="1ab"
/locus_tag="IBVgp1"
/note="putative TM helix 4 [structural motif]; Region:
putative TM helix 4"
/db_xref="CDD:394836"
misc_feature 8587..8856
/gene="1ab"
/locus_tag="IBVgp1"
/note="Coronavirus nonstructural protein 4 C-terminus;
Region: Corona_NSP4_C; pfam16348"
/db_xref="CDD:406690"
misc_feature 8869..9786
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 5, also
called Main protease (Mpro); Region: gammaCoV_Nsp5_Mpro;
cd21667"
/db_xref="CDD:394888"
misc_feature order(8869..8871,8875..8877,8881..8898,8905..8907,
9223..9240,9268..9282,9355..9369,9715..9717,9721..9726,
9760..9765)
/gene="1ab"
/locus_tag="IBVgp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:394888"
misc_feature order(8938..8946,8986..8988,9277..9294,9346..9357,
9373..9375,9418..9435)
/gene="1ab"
/locus_tag="IBVgp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:394888"
misc_feature 9748..10665
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 6; Region:
gammaCoV-Nsp6; cd21559"
/db_xref="CDD:394845"
misc_feature 10666..10914
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 7; Region:
gammaCoV_Nsp7; cd21828"
/db_xref="CDD:409254"
misc_feature order(10669..10671,10678..10689,10696..10704,10708..10713,
10720..10722,10747..10749,10756..10758,10774..10776,
10810..10827,10831..10848,10867..10881)
/gene="1ab"
/locus_tag="IBVgp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409254"
misc_feature 10915..11544
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 8; Region:
gammaCoV_Nsp8; cd21832"
/db_xref="CDD:409259"
misc_feature order(10924..10932,10939..10944,10948..10953,10963..10965,
10981..10986,11116..11118,11125..11127,11134..11139,
11161..11166,11173..11178,11182..11190,11194..11202,
11206..11226,11230..11238,11242..11247,11254..11259,
11263..11265,11269..11274,11281..11292,11371..11373)
/gene="1ab"
/locus_tag="IBVgp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409259"
misc_feature 11539..11877
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 9; Region:
gammaCoV_Nsp9; cd21899"
/db_xref="CDD:409332"
misc_feature 11545..11562
/gene="1ab"
/locus_tag="IBVgp1"
/note="N-finger; other site"
/db_xref="CDD:409332"
misc_feature order(11551..11559,11563..11568,11755..11763,11806..11808,
11824..11829,11833..11841,11845..11853,11857..11862)
/gene="1ab"
/locus_tag="IBVgp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409332"
misc_feature 11881..12282
/gene="1ab"
/locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 10; Region:
gammaCoV_Nsp10; cd21902"
/db_xref="CDD:409327"
misc_feature order(11881..11904,11914..11916,11920..11928,11932..11940,
11953..11958,11965..11970,11977..11979,11998..12015,
12052..12057,12085..12087,12091..12096,12106..12108,
12112..12129,12154..12162,12169..12180)
/gene="1ab"
/locus_tag="IBVgp1"
/note="Nsp14 interface [polypeptide binding]; other site"
/db_xref="CDD:409327"
misc_feature order(11920..11928,11932..11940,11953..11955,11998..12000,
12004..12015,12052..12060,12112..12123,12130..12132,
12175..12180,12232..12234)
/gene="1ab"
/locus_tag="IBVgp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409327"
misc_feature order(11953..11955,12004..12015,12052..12060,12130..12132,
12175..12180,12232..12234)
/gene="1ab"
/locus_tag="IBVgp1"
/note="homotrimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409327"
misc_feature order(11998..12021,12052..12057,12085..12096,12109..12114,
12118..12120,12169..12180)
/gene="1ab"
/locus_tag="IBVgp1"
/note="Nsp16 interface [polypeptide binding]; other site"
/db_xref="CDD:409327"
mat_peptide 12313..12381
/gene="1ab"
/locus_tag="IBVgp1"
/product="coronavirus nsp8"
/protein_id="NP_740621.1"
gene 20368..23856
/gene="2"
/locus_tag="IBVgp2"
/db_xref="GeneID:1489741"
CDS 20368..23856
/gene="2"
/locus_tag="IBVgp2"
/note="gene 2; label: S"
/codon_start=1
/product="spike protein"
/protein_id="NP_040831.1"
/db_xref="GeneID:1489741"
/translation="MLVTPLLLVTLLCALCSAVLYDSSSYVYYYQSAFRPPSGWHLQG
GAYAVVNISSEFNNAGSSSGCTVGIIHGGRVVNASSIAMTAPSSGMAWSSSQFCTAHC
NFSDTTVFVTHCYKHGGCPLTGMLQQNLIRVSAMKNGQLFYNLTVSVAKYPTFRSFQC
VNNLTSVYLNGDLVYTSNETIDVTSAGVYFKAGGPITYKVMREVKALAYFVNGTAQDV
ILCDGSPRGLLACQYNTGNFSDGFYPFTNSSLVKQKFIVYRENSVNTTCTLHNFIFHN
ETGANPNPSGVQNIQTYQTKTAQSGYYNFNFSFLSSFVYKESNFMYGSYHPSCKFRLE
TINNGLWFNSLSVSIAYGPLQGGCKQSVFKGRATCCYAYSYGGPSLCKGVYSGELDHN
FECGLLVYVTKSGGSRIQTATEPPVITQNNYNNITLNTCVDYNIYGRTGQGFITNVTD
SAVSYNYLADAGLAILDTSGSIDIFVVQGEYGLNYYKVNPCEDVNQQFVVSGGKLVGI
LTSRNETGSQLLENQFYIKITNGTRRFRRSITENVANCPYVSYGKFCIKPDGSIATIV
PKQLEQFVAPLFNVTENVLIPNSFNLTVTDEYIQTRMDKVQINCLQYVCGSSLDCRKL
FQQYGPVCDNILSVVNSVGQKEDMELLNFYSSTKPAGFNTPVLSNVSTGEFNISLLLT
NPSSRRKRSLIEDLLFTSVESVGLPTNDAYKNCTAGPLGFFKDLACAREYNGLLVLPP
IITAEMQALYTSSLVASMAFGGITAAGAIPFATQLQARINHLGITQSLLLKNQEKIAA
SFNKAIGHMQEGFRSTSLALQQIQDVVSKQSAILTETMASLNKNFGAISSVIQEIYQQ
FDAIQANAQVDRLITGRLSSLSVLASAKQAEYIRVSQQRELATQKINECVKSQSIRYS
FCGNGRHVLTIPQNAPNGIVFIHFSYTPDSFVNVTAIVGFCVKPANASQYAIVPANGR
GIFIQVNGSYYITARDMYMPRAITAGDVVTLTSCQANYVSVNKTVITTFVDNDDFDFN
DELSKWWNDTKHELPDFDKFNYTVPILDIDSEIDRIQGVIQGLNDSLIDLEKLSILKT
YIKWPWYVWLAIAFATIIFILILGWVFFMTGCCGCCCGCFGIMPLMSKCGKKSSYYTT
FDNDVVTEQYRPKKSV"
misc_feature 21634..23616
/gene="2"
/locus_tag="IBVgp2"
/note="SD-1 and SD-2 subdomains, the S1/S2 cleavage
region, and the S2 fusion subunit of the spike (S)
glycoprotein from avian infectious bronchitis coronavirus
(IBV) and related gammacoronaviruses; Region:
gammaCoV_Spike_SD1-2_S1-S2_S2; cd22372"
/db_xref="CDD:411959"
misc_feature 22033..22110
/gene="2"
/locus_tag="IBVgp2"
/note="S1/S2 cleavage region; other site"
/db_xref="CDD:411959"
misc_feature 22360..22410
/gene="2"
/locus_tag="IBVgp2"
/note="fusion peptide; other site"
/db_xref="CDD:411959"
misc_feature 22438..22491
/gene="2"
/locus_tag="IBVgp2"
/note="internal fusion peptide (IFP); other site"
/db_xref="CDD:411959"
misc_feature 22738..22935
/gene="2"
/locus_tag="IBVgp2"
/note="heptad repeat 1 [structural motif]; Region: heptad
repeat 1"
/db_xref="CDD:411959"
misc_feature 23500..23616
/gene="2"
/locus_tag="IBVgp2"
/note="heptad repeat 2 [structural motif]; Region: heptad
repeat 2"
/db_xref="CDD:411959"
gene 23856..24553
/gene="3"
/locus_tag="IBVgp3"
/db_xref="GeneID:1489742"
CDS 23856..24029
/gene="3"
/locus_tag="IBVgp3"
/note="ORF for gene 3; label: 3a"
/codon_start=1
/product="3a protein"
/protein_id="NP_040832.1"
/db_xref="GeneID:1489742"
/translation="MIQSPTSFLIVLILLWCKLVLSCFREFIIALQQLIQVLLQIINS
NLQSRLTLWHSLD"
misc_feature 23856..24026
/gene="3"
/locus_tag="IBVgp3"
/note="IBV 3A protein; Region: IBV_3A; pfam03617"
/db_xref="CDD:281600"
CDS 24029..24223
/gene="3"
/locus_tag="IBVgp3"
/note="ORF for gene 3; label: 3b"
/codon_start=1
/product="3b protein"
/protein_id="NP_040833.1"
/db_xref="GeneID:1489742"
/translation="MLNLEVIIETGEQVIQKISFNLQHISSVLNTEVFDPFDYCYYRG
GNFWEIESAEDCSGDDEFIE"
misc_feature 24029..24220
/gene="3"
/locus_tag="IBVgp3"
/note="IBV 3B protein; Region: IBV_3B; pfam03622"
/db_xref="CDD:281605"
CDS 24207..24533
/gene="3"
/locus_tag="IBVgp3"
/note="ORF for gene 3; label: sM"
/codon_start=1
/product="small virion-associated protein"
/protein_id="NP_040834.1"
/db_xref="GeneID:1489742"
/translation="MNLLNKSLEENGSFLTALYIIVGFLALYLLGRALQAFVQAADAC
CLFWYTWVVIPGAKGTAFVYKYTYGRKLNNPELEAVIVNEFPKNGWNNKNPANFQDAQ
RDKLYS"
misc_feature 24207..24482
/gene="3"
/locus_tag="IBVgp3"
/note="IBV 3C protein; Region: IBV_3C; pfam03620"
/db_xref="CDD:281603"
gene 24505..25182
/gene="M"
/locus_tag="IBVgp4"
/db_xref="GeneID:1489743"
CDS 24505..25182
/gene="M"
/locus_tag="IBVgp4"
/note="ORF for gene 4; label: M"
/codon_start=1
/product="membrane protein"
/protein_id="NP_040835.1"
/db_xref="GeneID:1489743"
/translation="MPNETNCTLDFEQSVQLFKEYNLFITAFLLFLTIILQYGYATRS
KVIYTLKMIVLWCFWPLNIAVGVISCTYPPNTGGLVAAIILTVFACLSFVGYWIQSIR
LFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPMVLSPIIKNGVLYCEGQWLAK
CEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVYAKQSVDTGELESVAT
GGSSLYT"
misc_feature 24523..25158
/gene="M"
/locus_tag="IBVgp4"
/note="gammacoronavirus Membrane (or Matrix) protein;
Region: gammaCoV_M; cd21566"
/db_xref="CDD:394852"
gene 25488..25930
/gene="5"
/locus_tag="IBVgp5"
/db_xref="GeneID:1489744"
CDS 25488..25685
/gene="5"
/locus_tag="IBVgp5"
/note="ORF for gene 5; label: 5a"
/codon_start=1
/product="5a protein"
/protein_id="NP_040836.1"
/db_xref="GeneID:1489744"
/translation="MKWLTSFGRAVISCYKSLLLTQLRVLDRLILDHGLLRVLTCSRR
VLLVQLDLVYRLAYTPTQSLA"
misc_feature 25488..25679
/gene="5"
/locus_tag="IBVgp5"
/note="Coronavirus 5a protein; Region: Corona_5a;
pfam06336"
/db_xref="CDD:283895"
CDS 25682..25930
/gene="5"
/locus_tag="IBVgp5"
/note="ORF for gene 5; label: 5b"
/codon_start=1
/product="5b protein"
/protein_id="NP_040837.1"
/db_xref="GeneID:1489744"
/translation="MNNSKDNPFRGAIARKARIYLREGLDCVYFLNKAGQAEPCPACT
SLVFQGKTCEEHIHNNNLLSWQAVKQLEKQTPQRQSLN"
misc_feature 25682..25927
/gene="5"
/locus_tag="IBVgp5"
/note="Coronavirus gene 5 protein; Region: Coronavirus_5;
pfam05528"
/db_xref="CDD:283238"
gene 25873..27102
/gene="N"
/locus_tag="IBVgp6"
/db_xref="GeneID:1489745"
CDS 25873..27102
/gene="N"
/locus_tag="IBVgp6"
/note="ORF for gene 6; label: N"
/codon_start=1
/product="nucleocapsid protein"
/protein_id="NP_040838.1"
/db_xref="GeneID:1489745"
/translation="MASGKAAGKTDAPAPVIKLGGPKPPKVGSSGNASWFQAIKAKKL
NTPPPKFEGSGVPDNENIKPSQQHGYWRRQARFKPGKGGRKPVPDAWYFYYTGTGPAA
DLNWGDTQDGIVWVAAKGADTKSRSNQGTRDPDKFDQYPLRFSDGGPDGNFRWDFIPL
NRGRSGRSTAASSAAASRAPSREGSRGRRSDSGDDLIARAAKIIQDQQKKGSRITKAK
ADEMAHRRYCKRTIPPNYRVDQVFGPRTKGKEGNFGDDKMNEEGIKDGRVTAMLNLVP
SSHACLFGSRVTPKLQLDGLHLRFEFTTVVPCDDPQFDNYVKICDQCVDGVGTRPKDD
EPKPKSRSSSRPATRGNSPAPRQQRPKKEKKLKKQDDEADKALTSDEERNNAQLEFYD
EPKVINWGDAALGENEL"
misc_feature 25936..26931
/gene="N"
/locus_tag="IBVgp6"
/note="N-terminal domain of nucleocapsid (N) protein of
coronavirus; Region: CoV_N-NTD; cl41918"
/db_xref="CDD:455263"
misc_feature order(25963..25986,26140..26142,26146..26148,26152..26154,
26266..26268,26287..26289)
/gene="N"
/locus_tag="IBVgp6"
/note="RNA binding site [nucleotide binding]; other site"
/db_xref="CDD:439219"
ORIGIN
1 acttaagata gatattaata tatatctatt acactagcct tgcgctagat ttttaactta
61 acaaaacgga cttaaatacc tacagctggt cctcataggt gttccattgc agtgcacttt
121 agtgccctgg atggcacctg gccacctgtc aggtttttgt tattaaaatc ttattgttgc
181 tggtatcact gcttgttttg ccgtgtctca ctttatacat ctgttgcttg ggctacctag
241 tgtccagcgt cctacgggcg tcgtggctgg ttcgagtgcg aggaacctct ggttcatcta
301 gcggtaggcg ggtgtgtgga agtagcactt cagacgtacc ggttctgttg tgtgaaatac
361 ggggtcacct ccccccacat acctctaagg gcttttgagc ctagcgttgg gctacgttct
421 cgcataaggt cggctatacg acgtttgtag ggggtagtgc caaacaaccc ctgaggtgac
481 aggttctggt ggtgtttagt gagcagacat acaatagaca gtgacaacat ggcttcaagc
541 ctaaaacagg gagtatctcc caaaccacgg gatgtcattc ttgtgtccaa agacatccct
601 gaacaacttt gtgacgcttt gtttttctat acgtcacata accctaagga ttacgctgat
661 gcttttgcag ttaggcagaa gtttgaccgt agtctccaga ctgggaaaca gttcaaattt
721 gaaactgtgt gtggtctctt cctcttgaag ggagttgaca aaataacacc tggcgtccca
781 gcaaaagttt taaaagccac ttctaagttg gcagatttag aagacatctt tggtgtctct
841 cctttagcgc ggaagtaccg tgaattgttg aaaacagcgt gtcagtggtc tcttactgta
901 gaagcactgg atgttcgtgc acaaactctc gatgaaattt ttgaccccac tgaaatactt
961 tggcttcagg tggctgcaaa aattcatgtt tcatctatgg caatgcgcag gcttgttgga
1021 gaagtaactg caaaagtcat ggatgctctg ggctcaaact tgagtgctct ttttcaaatt
1081 gttaaacaac aaatagccag aatctttcaa aaggcactgg ctatttttga gaatgtgaat
1141 gaattaccac agcgtattgc agcacttaag atggcttttg ccaagtgtgc taggtcaatt
1201 actgttgtgg ttgttgaaag aactctagtt gttaaagagt tcgcaggaac ttgtcttgca
1261 agcattaatg gtgctgtcgc aaaattcttt gaagagttgc caaacggctt catgggttct
1321 aagattttca caacacttgc cttctttaaa gaggcagctg tgagagttgt ggagaacata
1381 ccaaatgcac cgagaggtac taagggattt gaagttgttg gcaatgccaa aggcacacag
1441 gtagttgtgc gcggcatgcg aaatgactta acattgcttg accaaaaagc tgatattcct
1501 gttgaaccag aaggttggtc tgcaattttg gatggacatc tttgctatgt ctttaggagt
1561 ggtgatcgct tttatgctgc acctctttca ggaaattttg ctttgagtga tgttcattgc
1621 tgtgagcgtg tagtctgtct atctgatggt gtaacaccgg agataaatga tggactcatt
1681 ctagctgcaa tctactcttc ttttagtgtc tctgagcttg taacagctct taaaaagggt
1741 gaaccattca agttcttggg ccataaattc gtgtatgcga aggatgcagc agtgtctttt
1801 actttagcga aggctgccac tattgcagat gtcttgaggc tgtttcaatc agctcgtgtg
1861 atagcagaag atgtttggtc ttcatttact gaaaagtctt ttgaattctg gaagcttgca
1921 tatggaaaag tgcgcaacct tgaagaattt gtgaagacct atgtttgtaa ggctcaaatg
1981 tcgattgtga ttctagcagc agtgcttgga gaggacattt ggcatcttgt ctcacaagtc
2041 atctataaat taggtgttct ttttactaaa gtcgttgact tttgtgacaa acactggaaa
2101 ggtttttgtg tacagttgaa aagagctaag ctcattgtca ccgaaacctt ctgtgtttta
2161 aaaggagttg cacagcattg ttttcaactg ctgctagatg caatacactc tttgtacaag
2221 agttttaaga agtgtgcact tggtagaatc catggagatt tgctcttctg gaaaggaggt
2281 gtgcataaaa ttgttcaaga tggcgatgaa atatggtttg acgccattga tagtgttgat
2341 gttgaagatc tgggtgttgt tcaggaaaaa tcgattgatt ttgaggtttg cgatgacgtg
2401 acacttccag aaaaccaacc tggtcatatg gttcaaatag aggatgatgg taagaactac
2461 atgttcttcc gttttaaaaa ggatgagaac atttattata caccaatgtc tcaacttggt
2521 gctattaatg tggtttgcaa agcaggcggt aagactgtca cctttggaga aactacagta
2581 caagagatac caccacctga tgtcgtgcct attaaggtta gcatagaatg ttgtggtgaa
2641 ccatggaata cgatcttcaa gaaggcttat aaagagccta tagaagtaga tacagacctc
2701 acagtagaac aattgctctc tgtgatctat gagaaaatgt gtgacgacct taaattgttt
2761 ccagaggcac cagagcctcc accatttgag aatgtcgcac ttgttgataa gaacggtaaa
2821 gatttggatt gtataaaatc ttgccatttg atctatcgtg actatgagag cgatgatgac
2881 atcgaggagg aagatgctga ggagtgtgac acagactcag gtgaagctga ggagtgtgac
2941 actaattcag aatgtgaaga agaggatgag gatactaaag tgttggctct tatacaagac
3001 ccggcaagta ttaaataccc tctgcctctt gatgaagatt atagcgtcta taatggatgt
3061 attgtacaca aggacgctct tgatgttgtg aatttaccat ctggtgaaga aacttttgtt
3121 gtcaataact gttttgaggg agctgttaaa ccacttccac agaaggtagt tgatgttctt
3181 ggtgactggg gagaggctgt tgatgcgcaa gaacaactgt gtcaacaaga gcctctgcaa
3241 catacctttg aagaaccagt cgaaaattct actggtagtt ctaagacaat gactgaacaa
3301 gtcgttgtag aagatcaaga actacctgtt gttgaacaag atcaggatgt agttgtttat
3361 acacctacag atcttgaagt tgcaaaagaa acagcagaag aggttgatga gtttattctc
3421 atttttgctg ttcctaaaga agaagttgtg tcccagaaag atggggcaca gattaaacaa
3481 gagcctattc aagttgttaa accacaacgt gagaagaagg ctaaaaagtt caaagttaaa
3541 ccagccacat gtgagaaacc taaatttttg gagtataaaa catgtgtggg tgatttgact
3601 gttgtaattg ccaaagcatt ggatgagttt aaagagttct gcattgtaaa tgctgcaaat
3661 gagcatatga ctcatggtag tggcgttgca aaggcaattg cagacttttg tggactggat
3721 tttgttgaat attgtgagga ctatgttaag aaacatgggc cacaacagag acttgttaca
3781 ccttcgtttg tcaaaggcat tcaatgtgtg aataatgttg taggaccccg ccatggagac
3841 aacaacttgc atgagaagct tgttgctgcc tacaagaatg tgcttgtaga tggcgtagtc
3901 aattatgttg tgccagttct ttcattagga atttttggtg tagattttaa aatgtcaata
3961 gacgcaatgc gtgaagcttt tgaaggttgc accatacgcg ttcttttgtt ttctctgagc
4021 caagaacaca tcgattattt cgatgtaact tgcaaacaga agacaattta tcttacggag
4081 gatggtgtta aataccgctc cattgttcta aaacctggtg actcattggg tcaatttgga
4141 caggtttatg ctaaaaacaa gatagttttt acagccgatg atgttgagga caaagaaatt
4201 ctctacgtcc ccacgactga taaaagcatt cttgaatact atggtttaga tgcgcaaaag
4261 tatgtaatat atttgcaaac gcttgcgcag aaatggaatg tccaatatag ggacaatttt
4321 cttatactag agtggcgcga tggaaattgt tggattagtt cagcaatagt tctccttcaa
4381 gctgctaaaa ttaggtttaa aggttttcta acagaagcgt gggctaaact gttaggtgga
4441 gatcctacag actttgttgc ctggtgttat gcaagttgta ctgctaaagt aggtgatttc
4501 tcagatgcta attggctttt agcgaattta gcagaacatt ttgacgcaga ttacacaaat
4561 gcgtttctta agaagcgcgt ttcgtgtaac tgtggtatta agagctatga gcttagaggc
4621 cttgaagctt gtattcagcc agttcgggca actaatctgc tacattttaa gacgcaatat
4681 tcaaattgcc caacctgtgg cgcaaataat acggatgaag taatagaagc ttcgttaccg
4741 tacttattgc tttttgctac tgatggtcct gctacagttg attgtgatga agatgctgtg
4801 gggactgtcg tgtttgttgg ttctactaat agtggccatt gttatacaca agctgcaggg
4861 caagcttttg ataatcttgc taaagataga aaatttggaa agaagtcgcc ttacattact
4921 gcaatgtata cgcgattcgc ttttaagaat gaaacctctt tgcctgttgc taaacagagc
4981 aagggtaagt ctaagtcggt aaaggaagat gtttctaacc ttgctactag ttctaaggcc
5041 agttttgata atcttactga cttcgaacag tggtatgata gtaacatcta tgaaagtctt
5101 aaagtgcagg aatcacctga taactttgat aaatatgtgt cattcacaac aaaggaagat
5161 tctaagttgc cattgacact taaggttaga ggtattaaat cagttgttga ctttagatcg
5221 aaggatggtt ttatttataa gttaacacct gatactgatg aaaattcaaa agcaccagtc
5281 tactacccag tcttggacgc tattagtctt aaggcaatat gggtggaagg taatgctaac
5341 tttgttgttg gtcatccaaa ttattatagt aagtctcttc atattcctac tttttgggaa
5401 aatgctgaga attttgttaa aatgggtgat aaaattggtg gtgtaactat gggactttgg
5461 cgtgcagaac accttaataa acctaatttg gagagaattt tcaacattgc taagaaagcc
5521 attgttggat ctagtgttgt tactacacaa tgcggtaaat taataggtaa agcagctaca
5581 ttcattgctg ataaagtagg tggtggtgta gttcgcaata ttacagatag cattaagggt
5641 ctttgtggaa ttacacgagg gcattttgaa agaaaaatgt ctccacaatt cctaaagacg
5701 cttatgttct ttttattcta tttcttgaag gctagtgtta agagtgttgt cgctagctat
5761 aagaccgtgt tatgtaaggt ggtacttgct actttactta tagtttggtt tgtctacaca
5821 agtaacccag taatgtttac aggaatacgt gtgttagatt ttctattcga gggttctttg
5881 tgtggtcctt ataaagacta tggtaaagat tcttttgatg tgttacgata ttgtgcagat
5941 gattttattt gtcgtgtgtg tttacatgac aaagattcac ttcatttgta caaacacgct
6001 tatagtgtag agcaggtcta taaagatgca gcttctggtt ttatttttaa ttggaattgg
6061 ctttatttgg tctttctaat attatttgtt aaaccagtgg caggttttgt tattatttgc
6121 tattgtgtta agtatttggt attgaattca actgtgctgc aaactggtgt ttgtttttta
6181 gattggtttg tacaaacagt ttttagtcac tttaatttta tgggagcagg gttttatttc
6241 tggctctttt acaagatata tatacaggtg catcatatac tgtattgtaa ggatgtaaca
6301 tgtgaagtgt gcaaaagggt tgcacgcagc aacaggcaag aggttagcgt ggttgttggt
6361 ggacgcaagc agatagtgca tgtttacact aactctggct ataacttttg taagagacat
6421 aattggtatt gtagaaattg tgatgattat ggtcaccaaa atacatttat gtctcctgaa
6481 gttgctggcg agctctctga aaagcttaag cgccatgtta aacctacagc atacgcttac
6541 cacgttgtgg atgaggcatg cttagttgat gattttgtca atttaaaata taaagctgca
6601 actcctggta aggatagtgc atcttcagct gttaagtgtt tcagtgttac agatttcttg
6661 aagaaagctg tttttcttaa ggaagcactg aaatgtgaac aaatatctaa tgatggtttt
6721 atagtgtgta atacacagag tgctcatgca ttagaggaag caaagaatgc agccatctat
6781 tatgcgcaat atctgtgtaa gccaatactt atacttgacc aggcacttta tgagcaatta
6841 gtagtagagc ctgtgtctaa gagtgttata gataaagtgt gtagcatttt gtctagtata
6901 atatctgtag atactgcagc tttaaattat aaggcaggca cacttcgtga tgctctgctt
6961 tctattacta aagacgaaga ggccgtagat atggctatat tctgtcataa tcatgatgtg
7021 gattacactg gtgatggttt tactaatgtg ataccgtcat atggtataga cactggcaag
7081 ttaacacctc gtgatagagg gtttttgata aatgcagatg cttctattgc taacttaaga
7141 gttaaaaatg ctccgccggt agtatggaag ttttctgagc ttattaagtt gtctgacagt
7201 tgtcttaaat atttaatttc ggctactgtt aagtcaggtg ttcgtttctt tataacaaag
7261 tctggtgcta aacaagttat tgcttgtcat acacagaagt tgttagtaga gaaaaaggca
7321 ggtggtattg ttagcggcac ctttaagtgt tttaagagtt attttaaatg gctcttgatc
7381 ttttacatac tttttacagc atgttgttcg ggttattact atatggaggt gagtaaaagt
7441 tttgttcacc ccatgtatga tgtaaactcc acactgcatg ttgaaggttt taaagttata
7501 gataaaggtg ttcttaggga aattgtacca gaagatacat gtttctctaa taaatttgtt
7561 aattttgatg ctttttgggg cagaccatat gataatagta gaaactgtcc aattgtcaca
7621 gctgttatag atggtgatgg gacagtagct acaggtgttc ctggttttgt gtcctgggtt
7681 atggatggtg ttatgtttat acatatgaca cagactgaga gaaaaccgtg gtacattcct
7741 acttggttta atagagaaat tgtcggttac actcaggatt caattattac tgagggtagt
7801 ttttatacat ctatagcgtt attttccgct aggtgtttat atttaacagc cagcaataca
7861 cctcaattgt attgctttaa tggtgataat gatgcacctg gggctttgcc atttggtagt
7921 attattcctc atagagttta tttccaaccc aatggtgtta ggcttatagt tccacaacaa
7981 atactgcaca caccctacgt agtaaagttt gtatcagaca gctattgtag gggtagtgtg
8041 tgtgagtaca ctagaccagg ttactgtgtg tcattaaacc cacaatgggt tttgtttaat
8101 gacgaataca caagtaaacc cggtgttttc tgtggttcta ctgttagaga acttatgttt
8161 agtatggtta gtacattctt tactggtgtt aaccccaata tctatatgca attagcaact
8221 atgtttttaa tactagttgt tgttgtatta atctttgcaa tggttataaa gtttcaaggt
8281 gtttttaaag cttatgcaac cactgttttt ataacaatgt tagtttgggt aattaacgca
8341 tttattttgt gtgtacatag ttacaacagt gttttagctg ttatattact agtactctat
8401 tgctatgcgt cattggttac aagtcgcaat actgttataa taatgcattg ttggcttgtt
8461 tttacctttg gtttaatagt acccacatgg ttggcttgtt gctacctggg atttattatt
8521 tatatgtata caccgttgtt tttatggtgt tatggtacta caaaaaacac tcgtaagctg
8581 tatgatggca atgagtttgt tggtaattat gatcttgctg cgaagagcac ttttgttatt
8641 cgcggctctg aatttgttaa gcttactaat gagataggtg ataaatttga ggcctacctt
8701 tcagcgtatg ctagattaaa gtactattca ggcactggca gtgaacaaga ttatttgcaa
8761 gcttgtcgtg catggttagc ttatgctttg gaccaatata gaaatagtgg tgtggaaatt
8821 gtttatactc cgccacgtta ctctattggt gttagtagat tacaatctgg ttttaagaaa
8881 ctggtttctc ctagtagtgc tgttgaaaag tgcattgtta gtgtctctta tagaggtaat
8941 aatcttaatg gactgtggct aggtgacact atctactgtc ctcgtcatgt attgggtaag
9001 ttttcaggtg accaatggaa tgatgtactt aatcttgcta ataatcatga gtttgaagtt
9061 acaactcaac atggtgttac tttgaatgtt gtcagtaggc gtttaaaagg tgcagtttta
9121 attttacaaa ctgctgttgc taatgctgaa actccaaagt ataagtttat taaagctaat
9181 tgtggtgata gtttcactat agcttgtgct tatggtggta cagttgtagg actctaccct
9241 gttactatgc gttctaatgg tactattaga gcatcttttc ttgcgggagc ctgtggttca
9301 gttggtttta atatagaaaa gggtgtagtt aatttctttt atatgcacca tcttgagtta
9361 cctaatgcat tacacactgg aactgaccta atgggtgaat tctatggtgg ttatgttgat
9421 gaagaggttg cacaaagagt gccaccagat aatttagtta ctaacaatat tgtagcatgg
9481 ctctatgcgg caattattag tgttaaggag agtagtttct cgctgcctaa atggttggag
9541 agtactactg ttagtgttga tgattataat aagtgggctg gtgacaatgg ttttacacca
9601 ttttctacta gtaccgctat tactaaatta agtgctataa ctggagttga tgtttgtaag
9661 ctccttcgca ctattatggt aaaaaatagc cagtggggtg gtgaccccat tttagggcaa
9721 tataattttg aagatgaatt gacaccggag tctgtattta atcagattgg tggtgttaga
9781 ttacaatctt cttttgtaag aaaagctaca tcttggtttt ggagtagatg tgtgttagct
9841 tgcttcttat ttgtgttgtg tgctattgtc ttgtttacgg cagtgccact taaattttat
9901 gtatatgcag ctgttatttt gttaatggct gtacttttta tttcttttac tgttaaacat
9961 gttatggcat atatggatac ttttctattg ccaacattga ttacagttat tattggagtt
10021 tgtgctgaag tgcctttcat ctacaatact ctaattagtc aagttgttat tttcttaagt
10081 caatggtatg acccagtagt ctttgatact atggtaccat ggatgttctt gccactagtg
10141 ttgtatactg cttttaagtg tgtacaaggt tgctatatga attctttcaa tacttctttg
10201 ttaatgctgt atcagtttgt gaagttaggt tttgttattt acacctcttc taatactctt
10261 actgcataca cagaaggtaa ttgggagtta ttcttcgagt tggtgcacac tactgtgttg
10321 gctaatgtta gtagtaattc tttaattggt ttatttgttt ttaagtgtgc taaatggatg
10381 ttgtattatt gtaatgcaac atacttaaac aattatgtac taatggcagt tatggttaac
10441 tgcattggct ggctctgcac ttgttacttt gggttgtatt ggtgggttaa taaggttttt
10501 ggtttaacct taggtaaata caattttaaa gtttcagtag atcaatatag gtatatgtgt
10561 ttgcacaaga taaacccacc taaaactgtg tgggaagtct tttcgacaaa tatacttata
10621 caaggaattg gtggtgaccg tgtgttgcct attgctacag ttcaagctaa attgagtgat
10681 gtaaagtgta caactgttgt tttaatgcag cttttgacta agcttaatgt tgaagcaaat
10741 tcaaaaatgc atgtttatct tgttgagtta cacaataaaa ttcttgcttc tgatgatgtt
10801 ggagagtgca tggataattt gttgggtatg cttataacac tattttgtat agattctact
10861 attgatttga gtgagtattg tgatgacata cttaagaggt caactgtatt acaatcggtt
10921 actcaagaat tctcacatat accctcttat gctgaatatg aaagggctaa gaatctttat
10981 gaaaaggttt tagttgattc taaaaatggt ggtgttacac agcaagagct tgctgcatat
11041 cgtaaagctg ccaatattgc aaagtcagtt tttgatagag acttggctgt ccaaaagaag
11101 ttagatagca tggcagagcg tgctatgaca acaatgtata aagaggcgcg tgtaacagat
11161 agacgagcaa aattagtctc atcactacat gcgttacttt tctcaatgct taagaaaata
11221 gattctgaaa agcttaatgt cttgtttgac caggctagta gtggtgttgt gcccctagcg
11281 actgttccaa ttgtttgtag taataagctt acacttgtaa taccagaccc agaaacgtgg
11341 gtcaagtgtg tggaaggtgt gcatgttaca tattcaacag ttgtttggaa tatagacact
11401 gttattgatg ccgatggcac agagttacac ccaacttcta caggtagtgg attgacatac
11461 tgtataagtg gtgctaatat agcatggcct ttaaaggtta acttgactag gaatgggcat
11521 aataaggttg atgttgtttt gcaaaataat gagcttatgc cacatggtgt taaaacaaag
11581 gcttgcgtag caggtgtaga tcaagcacat tgtagcgtag agtctaaatg ttattataca
11641 aatattagtg gcaattcagt tgtagctgct attacttctt caaatccaaa tctgaaagta
11701 gcttcgtttt tgaatgaggc aggcaatcag atttatgtag acttagaccc accatgtaaa
11761 tttggcatga aagtgggtgt caaggttgag gttgtttact tgtattttat aaagaataca
11821 aggtcgattg ttaggggtat ggtacttggt gctatatcta atgttgttgt cttacagtct
11881 aaagggcatg aaacagagga agtggatgct gttggcattc tttcactatg ttcatttgca
11941 gtagatcccg cggacacata ttgtaaatat gtggcagcag gtaatcaacc tttaggtaac
12001 tgtgttaaaa tgttgacagt gcataatggt agtggttttg ctataacttc aaagccaagt
12061 cctactcctg accaggattc ttatggagga gcttctgtgt gtctctattg tagagcacac
12121 atagcacatc caggaagtgt aggaaattta gatggacgtt gtcaatttaa aggttctttt
12181 gtgcaaatac ctactacgga gaaagacccc gttggattct gtctacgtaa taaggtttgc
12241 actgtttgcc agtgttggat tggttatgga tgtcagtgtg attcacttag acaaccaaaa
12301 tcttctgttc aatcagttgc tggagcatct gattttgata agaattattt aaacgggtac
12361 ggggtagcag tgaggctcgg ctgatacccc ttgctagtgg atgtgatcct gatgttgtaa
12421 agcgagcctt tgatgtttgt aataaggaat cagctggtat gtttcaaaat ttgaagcgta
12481 actgcgctag attccaggaa ctacgcgata ctgaagatgg aaatcttgag tatcttgatt
12541 cttactttgt agttaaacaa accactccta gtaattatga acatgaaaaa tcttgttacg
12601 aagacttaaa gtcagaagta acagctgacc atgacttctt tgtgttcaat aagaacattt
12661 acaatattag taggcaacgg cttactaaat atactatgat ggacttctgc tatgctttga
12721 gacatttcga cccaaaggat tgtgaagttc ttaaagaaat acttgtcact tatggttgta
12781 tagaagacta tcaccctaag tggtttgagg agaataagga ttggtacgac ccaatagaaa
12841 actcaaaata ttatgtcatg ttggctaaaa tgggacctat tgtacgacgt gctttattga
12901 atgctattga gttcggaaac cttatggttg aaaaaggtta tgttggtgtt attacactcg
12961 ataaccaaga ccttaatggc aaattttatg attttggtga ttttcagaag acggcacctg
13021 gtgctggtgt tcctgttttt gatacgtatt attcttacat gatgcccatc atagccatga
13081 cggatgcttt agcacctgag aggtactttg aatatgatgt gcacaagggt tataaatctt
13141 atgatctcct caagtatgat tatactgagg agaaacaaga attgtttcag aagtacttta
13201 agtactggga tcaagagtat catcctaact gccgtgactg tagtgatgac aggtgtttga
13261 tacattgtgc aaacttcaat atcttgtttt ctacacttat accgcagact tctttcggta
13321 atttgtgtag aaaagttttt gttgatggtg taccatttat agctacttgt ggctatcatt
13381 ctaaggaact tggtgttatt atgaatcaag ataacaccat gtctttttca aaaatgggtt
13441 taagtcaact catgcagttt gttggagatc ctgctttgtt agtgggaaca tccaataatt
13501 tagttgatct tagaacgtct tgttttagtg tttgtgcgtt aacatctggt attactcatc
13561 aaacggtaaa gccaggtcac tttaacaagg atttctatga ttttgcagag aaggctggta
13621 tgtttaagga gggttcgtct ataccactta aacatttttt ctatcctcaa actggtaatg
13681 ctgctataaa cgattatgat tattatcgtt ataacaggcc taccatgttt gacatatgtc
13741 aacttctatt ttgtttagaa gtgacttcta aatactttga gtgttatgaa ggcggctgta
13801 taccagctag ccaagttgta gttaacaact tagataagag tgcaggctat ccatttaata
13861 agtttggaaa agcccgcctc tattatgaaa tgagtctaga ggaacaggac caactcttcg
13921 agattacgaa gaagaatgtc ctacccacta taactcaaat gaatttaaaa tatgccatat
13981 ccgcgaaaaa tagagcgcgt acagtggcag gtgtgtctat cctttctact atgactaata
14041 ggcagtttca tcagaagatt cttaagtcta tagtcaacac tagaaatgct tctgtagtta
14101 ttggaacaac caagttttat ggcggttggg acaacatgtt gagaaacctg attcagggtg
14161 ttgaagaccc aattcttatg ggttgggatt atcctaagtg tgatagagca atgcctaatt
14221 tgttgcgtat agcagcatcc ttagtacttg ctcgcaaaca cactaactgt tgtagttggt
14281 ctgaacgcat ttataggttg tataatgaat gcgcccaggt cttatctgaa actgtacttg
14341 ctacaggtgg tatttatgtt aaacctggtg gcactagcag tggtgatgct actactgctt
14401 atgcaaacag tgtttttaac ataatacaag ccacatctgc taatgttgcg cgtcttttga
14461 gtgttataac gcgtgatatt gtctatgata atattaagag cttgcagtat gaattgtatc
14521 agcaggtcta caggcgagtt aattttgacc cagcctttgt tgaaaagttt tattcttact
14581 tatgtaagaa tttttcgttg atgatcttgt ctgacgacgg tgttgtttgt tacaacaaca
14641 cattagccaa acaaggtctt gtagcagata tttctggttt tagagaggtt ctctactatc
14701 agaataatgt ttttatggct gattctaaat gttgggttga accagattta gaaaaaggcc
14761 cacatgagtt ttgttcacaa cacacaatgc tagtggaggt tgatggtgag cctaagtatt
14821 tgccataccc agacccttca cgcattttgg gtgcatgtgt ttttgtagat gacgtggata
14881 agacagaacc tgtggctgtt atggagcgtt atatagctct tgccatagat gcttatccac
14941 tagtacatca tgaaaatgaa gagtacaaga aggtattctt tgttctcctt gcatatatca
15001 gaaaactcta tcaagagctt tctcagaata tgcttatgga ctactctttt gtaatggata
15061 tagacaaggg tagtaaattt tgggaacagg agttctatga gaatatgtat agagctccta
15121 cgactttaca atcttgtggc gtttgtgtag tttgtaatag tcaaactata ctacgctgcg
15181 gtaattgtat tcgtaaaccg tttttgtgtt gtaagtgttg ctatgaccac gtcatgcata
15241 cggaccacaa aaatgtttta tctataaatc cttatatttg ctcacagcta ggttgcggtg
15301 aagcagatgt tactaaattg tacctcgggg gtatgtcgta cttctgtggt aatcataaac
15361 cgaaattgtc aataccgtta gtatctaatg gtactgtttt tggaatttac agggctaatt
15421 gtgctggtag tgaaaatgtt gatgatttta atcaactagc tactactaat tggtccattg
15481 tcgaacctta tattttagca aatcgctgta gtgattcatt gagacgtttt gctgcagaga
15541 cagtaaaagc cacagaagaa ttacataagc aacaatttgc tagtgcagaa gtgcgagaag
15601 tattctcaga tcgtgaattg attctatcat gggaaccagg aaaaaccagg ccgccattga
15661 atagaaatta tgttttcaca ggttatcact ttacaagaac tagtaaggtg cagcttggtg
15721 attttacatt tgaaaaaggt gaaggtaagg atgttgtcta ttataaagca acgtctactg
15781 ctaaattgtc tgtaggagac atttttgttt taacctcaca caatgttgtt tctctcgtag
15841 cgccaacatt gtgtccacaa caaacctttt ctaggtttgt aaatttaaga cctaatgtaa
15901 tggtacctga atgttttgta aataacattc cactttacca tttagtaggt aaacagaagc
15961 gtactacagt acaaggtcct cctggcagtg gtaaatccca ctttgctata ggccttgcag
16021 tatactttag tagcgctcgt gttgttttta ctgcatgttc tcatgcagct gttgatgctt
16081 tatgtgaaaa agcttttaag tttcttaaag ttgatgattg cactcgtata gtaccccaaa
16141 ggactactgt cgattgcttc tcaaaattta aagctaatga cacaggcaaa aagtacattt
16201 ttagtactat taatgccttg ccggaagtta gttgtgatat tcttttggtt gacgaggtta
16261 gtatgttgac caattacgaa ttgtccttta ttaatggtaa gataaattac caatatgttg
16321 tgtatgtagg tgatccggct caattaccgg caccccgcac tttacttaat ggttcacttt
16381 ctccaaagga ttataatgtt gtcacaaacc ttatggtttg tgttaaacct gatattttcc
16441 ttgcaaagtg ttatcgttgt cctaaggaaa ttgtagacac tgtgtctact cttgtttatg
16501 atggaaagtt tattgcaaat aacccagaat cacgtgagtg tttcaaggtt atagttaata
16561 atggcaattc tgatgtagga catgaaagtg gttcagccta caacacaaca caattggaat
16621 ttgtgaaaga ctttgtttgt cgcaataaac aatggcggga agcaatattt atttcacctt
16681 acaatgctat gaaccagaga gcttaccgta tgcttggact taatgttcaa acagtagatt
16741 cttctcaagg ttcagagtat gattatgtca tcttctgtgt tactgcagat tcgcagcatg
16801 cactgaatat taatagattt aatgtggcgc ttacaagagc taagcgtggt atactagttg
16861 tcatgcgcca gcgtgatgaa ttgtattctg ctcttaagtt tacagagcta gatagtgaaa
16921 caagtctgca aggtacaggt ttgtttaaaa tttgcaacaa agaatttagt ggtgtccatc
16981 ctgcttatgc agtcacaact aaggctcttg ctgcaaccta taaagttaat gatgaacttg
17041 ctgcacttgt taatgtggaa gctggttcag aaataacata taaacatctt atttctctgt
17101 taggattcaa gatgagtgtt aatgttgaag gctgccacaa catgtttata acacgtgatg
17161 aggcaatccg caatgtaaga ggttgggtag gttttgatgt agaagcaaca catgcttgtg
17221 gcactaacat tggtactaac ctgccttttc aagtaggttt ctctactggt gcagactttg
17281 tagtcacgcc tgagggactt gtagatactt caataggcaa taattttgag cctgtgaatt
17341 ctaaagcacc tccaggtgaa caatttaacc acttgagagt gttatttaaa agtgctaaac
17401 cttggcatgt tataagacca aggatagtgc agatgttagc agacaatcta tgcaacgttt
17461 cagattgtgt agtgtttgtc acatggtgtc atggcctaga actaactact ttgcgctatt
17521 ttgttaaaat aggcaaggaa caagtttgtt cttgtggttc tagagctaca acttttaatt
17581 ctcatactca agcttatgct tgttggaagc attgtttggg ttttgatttt gtttataacc
17641 cacttctagt ggatattcaa cagtggggtt actcgggtaa cctacagttt aatcatgatt
17701 tgcactgtaa tgtgcatggc cacgctcatg tagcttctgt tgacgctata atgactcgtt
17761 gtcttgcaat taacaatgca ttttgtcaag atgtcaactg ggatttgaca taccctcaca
17821 ttgcaaatga ggatgaagtc aattctagtt gtagatatct acaacgcatg tatcttaatg
17881 cgtgtgttga tgctcttaaa gttaatgttg tctatgatat aggcaaccct aaaggtatta
17941 aatgtgttag gcgtggggat gttaatttta gattctatga taagaatcca atagtacgca
18001 acgtcaagca gtttgagtat gactataatc agcacaaaga taagtttgct gatggtcttt
18061 gtatgttttg gaattgtaat gtggattgtt atcctgataa ttccttggtt tgtaggtatg
18121 acacacgaaa tttgagtgtg tttaacctac caggctgtaa tggtggtagt ctgtacgtta
18181 acaaacatgc attctacaca cctaaatttg accgcattag cttccgcaat ttgaaagcta
18241 tgccattctt tttttatgac tcatcgcctt gtgaaaccat tcaagtggat ggagttgcgc
18301 aagaccttgt gtctctagct acgaaagact gtatcacaaa gtgcaacatt ggtggcgctg
18361 tttgtaagaa acatgcccag atgtatgcag aatttgtgac ttcttacaat gcagctgtca
18421 cagctggctt tactttctgg gtaactaata aacttaaccc ttataactta tggaaaagtt
18481 tttcagctct ccagtctatc gacaatattg cttataatat gtataagggt ggtcattatg
18541 atgctattgc tggagaaatg cccactgtca taactggaga caaagttttt gttattgatc
18601 aaggtgtaga aaaggcagtt tttgttaatc aaacaactct acctacatct gtggcgtttg
18661 agctatatgc aaagagaaat attcgcacac tgccaaacaa ccgtattttg aaaggtttag
18721 gtgtagacgt aaccaatgga tttgtaattt gggattatgc taaccaaaca ccattgtatc
18781 gtaataccgt caaggtatgt gcatatacag atattgagcc aaatggccta gtagttctgt
18841 atgatgatag atatggtgat taccagtctt ttcttgctgc tgataatgct gttctagttt
18901 ctacacagtg ttataagcga tattcatacg tagaaatacc atctaatttg ctcgttcaga
18961 atggtatgcc attaaaagat ggagcgaacc tgtatgttta taagcgtgtt aatggtgcgt
19021 ttgttacact acctaacaca ataaacaccc agggtcgaag ttatgaaact tttgaacctc
19081 gtagtgacat tgagcgtgat tttctcgcta tgtcagagga gagttttgta gaaaggtatg
19141 gtaaagactt aggcctacaa cacatactgt atggtgaagt tgataagccc caattaggtg
19201 gtttacacac tgttataggt atgtacagac tcttacgtgc gaataagttg aacgcaaagt
19261 ctgtaactaa ttcggattct gatgtcatgc aaaattactt tgtattgtcg gacaatggtt
19321 cttacaagca agtgtgtact gttgtggatt tactgcttga tgatttctta gaacttctta
19381 gaaacatact taaggagtat ggtactaata agtcaaaagt tgtaacagtg tcaattgatt
19441 accatagcat aaattttatg acttggtttg aagatggcag tattaaaaca tgttatccac
19501 agcttcaatc agcatggacg tgtggttata atatgcctga actttataaa gttcagaatt
19561 gtgttatgga accttgcaac attcctaatt atggtgttgg aataacgttg cctagcggta
19621 ttcttatgaa tgtggcaaag tatacacaac tttgtcaata cctttcgaaa acaacaattt
19681 gtgtaccgca taacatgcga gtaatgcatt tcggagcagg aagcgacaaa ggagtggcgc
19741 caggtagtac tgttcttaaa caatggctcc cagaagggac actccttgtc gataatgata
19801 ttgtagacta tgtgtctgat gcacatgttt ctgtgctttc agattgcaat aaatataata
19861 cagagcacaa gtttgatctt gtgatatctg atatgtatac agataatgat tcaaaaagaa
19921 agcatgaagg cgtgatagcc aataatggca atgatgacgt tttcatatat ctctcaagtt
19981 ttcttcgtaa caatttggct ctaggtggta gttttgctgt aaaagtgaca gagacaagtt
20041 ggcacgaagt tttatatgac attgcacagg attgtgcatg gtggacaatg ttttgtacag
20101 cagtgaatgc ctcttcttca gaagcattct tgattggtgt taattatttg ggtgcaagtg
20161 aaaaggttaa ggttagtgga aaaacgctgc acgcaaatta tatattttgg aggaattgta
20221 attatttaca aacctctgct tatagtatat ttgacgttgc taagtttgat ttgagattga
20281 aagcaacgcc agttgttaat ttgaaaactg aacaaaagac agacttagtc tttaatttaa
20341 ttaagtgtgg taagttactg gtaagagatg ttggtaacac ctcttttact agtgactctt
20401 ttgtgtgcac tatgtagtgc tgttttgtat gacagtagtt cttacgttta ctactaccaa
20461 agtgccttca gaccacctag tggttggcat ttacaagggg gtgcttatgc ggtagttaac
20521 atttctagcg aatttaataa tgcaggctct tcatcagggt gtactgttgg tattattcat
20581 ggtggtcgtg ttgttaatgc ttcttctata gctatgacgg caccgtcatc aggtatggct
20641 tggtctagca gtcagttttg tactgcacac tgtaattttt cagatactac agtgtttgtt
20701 acacattgtt ataaacatgg tgggtgtcct ttaactggca tgcttcaaca gaatcttata
20761 cgtgtttctg ctatgaaaaa tggccagctt ttctataatt taacagttag tgtagctaag
20821 taccctactt ttagatcatt tcagtgtgtt aataatttaa catccgtata tttaaatggt
20881 gatcttgttt acacctctaa tgagaccata gatgttacat ctgcaggtgt ttattttaaa
20941 gctggtggac ctataactta taaagttatg agagaagtta aagccctggc ttattttgtt
21001 aatggtactg cacaagatgt tattttgtgt gatggatcac ctagaggctt gttagcatgc
21061 cagtataata ctggcaattt ttcagatggc ttttatcctt ttactaatag tagtttagtt
21121 aagcagaagt ttattgtcta tcgtgaaaat agtgttaata ctacttgtac gttacacaat
21181 ttcatttttc ataatgagac tggcgccaac cctaatccta gtggtgttca gaatattcaa
21241 acttaccaaa caaaaacagc tcagagtggt tattataatt ttaatttttc ctttctgagt
21301 agttttgttt ataaggagtc taattttatg tatggatctt atcacccaag ttgtaaattt
21361 agactagaaa ctattaataa tggcttgtgg tttaattcac tttcagtttc aattgcttac
21421 ggtcctcttc aaggtggttg caagcaatct gtctttaaag gtagagcaac ttgttgttat
21481 gcttattcat atggaggtcc ttcgctgtgt aaaggtgttt attcaggtga gttagatcat
21541 aattttgaat gtggactgtt agtttatgtt actaagagcg gtggctctcg tatacaaaca
21601 gccactgaac cgccagttat aactcaaaac aattataata atattacttt aaatacttgt
21661 gttgattata atatatatgg cagaactggc caaggtttta ttactaatgt gaccgactca
21721 gctgttagtt ataattatct agcagacgca ggtttggcta ttttagatac atctggttcc
21781 atagacatct ttgttgtaca aggtgaatat ggtcttaatt attataaggt taacccttgc
21841 gaagatgtca accagcagtt tgtagtttct ggtggtaaat tagtaggtat tcttacttca
21901 cgtaatgaga ctggttctca gcttcttgag aaccagtttt acatcaaaat cactaatgga
21961 acacgtcgtt ttagacgttc tattactgaa aatgttgcaa attgccctta tgttagttat
22021 ggtaagtttt gtataaaacc tgatggctca attgccacaa tagtaccaaa acaattggaa
22081 cagtttgtgg cacctttatt taatgttact gaaaatgtgc tcatacctaa cagtttcaac
22141 ttaactgtta cagatgagta catacaaacg cgtatggata aggtccaaat taattgcctg
22201 cagtatgttt gtggcagttc tctggattgt agaaagttgt ttcaacaata tgggcctgtt
22261 tgcgacaaca tattgtctgt agtaaatagt gttggtcaaa aagaagatat ggaacttttg
22321 aatttctatt cttctactaa accggctggt tttaatacac cagttcttag taatgttagc
22381 actggtgagt ttaatatttc tcttctgtta acaaatccta gtagtcgtag aaagcgttct
22441 cttattgaag accttctatt tacaagcgtt gaatctgttg gactaccaac aaatgacgca
22501 tataaaaatt gcactgcagg acctttaggc ttttttaagg accttgcgtg tgctcgtgaa
22561 tataatggtt tgcttgtgtt gcctcctatc ataacagcag aaatgcaagc tttgtatact
22621 agttctctag tagcttctat ggcttttggt ggtattactg cagctggtgc tatacctttt
22681 gccacacaac tgcaggctag aattaatcac ttgggtatta cccagtcact tttgttgaag
22741 aatcaagaaa aaattgctgc ttcctttaat aaggccattg gtcatatgca ggaaggtttt
22801 agaagtacat ctctagcatt acaacaaatt caagatgttg ttagtaaaca gagtgctatt
22861 cttactgaga ctatggcatc acttaataaa aattttggtg ctatttcttc tgtgattcaa
22921 gaaatctacc agcaatttga cgccatacaa gcaaatgctc aagtggatcg tcttataact
22981 ggtagattgt catcactttc tgttttagca tctgctaagc aggcggagta tattagagtg
23041 tcacaacagc gtgagttagc tactcagaaa attaatgagt gtgttaagtc acagtctatt
23101 aggtactcct tttgtggtaa tggacgacat gttctaacca taccgcaaaa tgcacctaat
23161 ggtatagtgt ttatacactt ttcttatact ccagatagtt ttgttaatgt tactgcaata
23221 gtgggttttt gtgtaaagcc agctaatgct agtcagtatg caatagtgcc cgctaatggt
23281 aggggtattt ttatacaagt taatggtagt tactacatca ctgcacgaga tatgtatatg
23341 ccaagagcta ttactgcagg agatgtagtt acgcttactt cttgtcaagc aaattatgta
23401 agtgtaaata agaccgtcat tactacattc gtagacaatg atgattttga ttttaatgac
23461 gaattgtcaa aatggtggaa tgatactaag catgagctac cagactttga caaattcaat
23521 tacacagtac ctatacttga cattgatagt gaaattgatc gtattcaagg cgttatacag
23581 ggtcttaatg actctctaat agaccttgaa aaactttcaa tactcaaaac ttatattaag
23641 tggccttggt atgtgtggtt agccatagct tttgccacta ttatcttcat cttaatacta
23701 ggatgggttt tcttcatgac tggttgttgt ggttgttgtt gtggatgctt tggcattatg
23761 cctctaatga gtaagtgtgg taagaaatct tcttattaca cgacttttga taacgatgtg
23821 gtaactgaac aatacagacc taaaaagtct gtttgatgat ccaaagtccc acgtccttcc
23881 taatagtatt aattcttctt tggtgtaaac ttgtactaag ttgttttaga gagtttatta
23941 tagcgctcca acaactaata caagttttac tccaaattat caatagtaac ttacagtcta
24001 gactgaccct ttggcacagt ctagactaat gttaaactta gaagtaatta ttgaaactgg
24061 tgagcaagtg attcaaaaaa tcagtttcaa tttacagcat atttcaagtg tattaaacac
24121 agaagtattt gatccctttg actattgtta ttacagagga ggtaattttt gggaaataga
24181 gtcagctgaa gattgttcag gtgatgatga atttattgaa taagtcgcta gaggagaatg
24241 gaagttttct aacagcgctt tacataattg taggattttt agcactttat cttctaggta
24301 gagcacttca agcatttgta caggctgctg atgcttgttg tttattttgg tatacatggg
24361 tagtaattcc aggagctaag ggtacagcct ttgtatacaa gtatacatat ggtagaaaac
24421 ttaacaatcc ggaattagaa gcagttattg ttaacgagtt tcctaagaac ggttggaata
24481 ataaaaatcc agcaaatttt caagatgccc aacgagacaa attgtactct tgactttgaa
24541 cagtcagttc agctttttaa agagtataat ttatttataa ctgcattctt gttgttctta
24601 accataatac ttcagtatgg ctatgcaaca agaagtaagg ttatttatac actgaaaatg
24661 atagtgttat ggtgcttttg gccccttaac attgcagtag gtgtaatttc atgtacatac
24721 ccaccaaaca caggaggtct tgtcgcagcg ataatactta cagtgtttgc gtgtctgtct
24781 tttgtaggtt attggatcca gagtattaga ctctttaagc ggtgtaggtc atggtggtca
24841 tttaatccag aatctaatgc cgtaggttca atactcctaa ctaatggtca acaatgtaat
24901 tttgctatag agagtgtgcc aatggtgctt tctccaatta taaagaatgg tgttctttat
24961 tgtgagggtc agtggcttgc taagtgtgaa ccagaccact tgcctaaaga tatatttgtt
25021 tgtacaccgg atagacgtaa tatctaccgt atggtgcaga aatatactgg tgaccaaagc
25081 ggaaataaga aaaggtttgc tacgtttgtc tatgcaaagc agtcagtaga tactggcgag
25141 ctagaaagtg tagcaacagg aggaagtagt ctttacacat aaatgtgtgt gtgtagagag
25201 tatttaaaat tattctttaa tagcgcctct gttttaagag cgcataagag tatttatttt
25261 gaggatacta atataaatcc tctttgtttt atactctcct ttcaagagct attaacggtg
25321 ttacctttca agtagataat ggaaaagtct actacgaagg aacaccagtt ttccaaaaag
25381 gttgttgtag gatgtggtcc aattataaga aagaataatt gaaccaccta ctacacttat
25441 ttttataaga ggtgttttac ttaacaaaaa cttaacaaat acggacgatg aaatggctga
25501 ctagttttgg aagagcagtt atttcttgtt ataaatccct actattaact caacttagag
25561 tgttagatag gttaatttta gatcacggac tactacgcgt tttaacgtgt agtaggcgcg
25621 tgcttttagt tcaattagat ttagtttata ggttggcgta tacgcccacc caatcgctgg
25681 catgaataat agtaaagata atccttttcg cggagcaata gcaagaaaag ctcgaattta
25741 tctgagagaa ggattagatt gtgtttactt tcttaacaaa gcaggacaag cagagccttg
25801 tcccgcgtgt acctctctag tattccaagg gaaaacttgt gaggaacaca tacataataa
25861 taatcttttg tcatggcaag cggtaaagca gctggaaaaa cagacgcccc agcgccagtc
25921 attaaactag gaggaccaaa accacctaaa gtcggttctt ctggaaatgc atcttggttt
25981 caagcaataa aagccaagaa gttaaataca cctccgccca agtttgaagg tagcggtgtt
26041 cctgataacg aaaacattaa gccaagccag caacatggat actggagacg ccaagccagg
26101 tttaagccag gcaaaggtgg aagaaaacca gtcccagatg cttggtactt ttactatact
26161 ggaacaggac ctgccgctga cctgaactgg ggtgatactc aagatggtat agtgtgggtt
26221 gctgctaagg gtgctgatac taaatctaga tccaatcagg gtacaagaga tcctgataag
26281 tttgaccaat acccactacg attctcggat ggcggacctg atggtaattt ccgttgggac
26341 ttcattcccc tgaaccgtgg taggagtgga agatcaacag cagcttcatc agcagcagct
26401 agtagagcac catcacgtga aggttcgcgt ggtcgtagaa gtgattctgg agatgacctt
26461 attgctcgtg cagcaaagat aatccaggat cagcagaaaa agggctctcg cattaccaag
26521 gcaaaggcag atgaaatggc tcatcgccgg tattgcaagc gcactatccc acctaattat
26581 agggttgatc aagtgtttgg tccccgtact aaaggtaagg aggggaattt tggtgatgac
26641 aagatgaatg aggaaggtat taaggatggg cgtgttacag caatgctcaa cctagtccct
26701 agcagccatg cttgtctttt tggaagtaga gtgacaccca aacttcaact agatgggctt
26761 cacttgagat ttgaatttac tactgtggtc ccatgtgatg acccgcagtt tgataattat
26821 gtgaaaattt gtgatcagtg tgtcgatggt gtaggaacgc gtccaaaaga tgacgaacca
26881 aaaccaaagt cacgctcaag ttcaagacct gctacaagag gaaattctcc agcgccaaga
26941 caacagcgcc caaagaagga gaaaaagcta aagaagcagg atgatgaagc agataaagca
27001 ttgacctcag atgaggagag gaacaatgca cagctggaat tttatgatga gcccaaggta
27061 attaactggg gggatgcagc tctaggagag aatgaacttt gagtaacata atggacctgt
27121 tgtttcctgg tacattttgt taaacactat ttctgtgctt tcctatcaat tattacaggc
27181 attgattgtg attatgttca atacttaagc ttcttttggt tgctttttgc ttattgtatt
27241 gttgctgtgc tttttattgt tgtgattctc attagtttgc tttatcgtag aaattcaata
27301 gtaagagtta aggaagatag gcatgtagct tgattaccta catgtctatc gccagggaaa
27361 tgtctaatct gtctacttag tagcctggaa acgaacggta gacccttaga ttttaattta
27421 gtttaatttt tagtttagtt taagttagtt tagagtaggt ataaagatgc cagtgccggg
27481 gccacgcgga gtacgatcga gggtacagca ctaggacgcc cattagggga agagctaaat
27541 tttagtttaa gttaagttta attggctaag tatagttaaa atttataggc tagtatagag
27601 ttagagca
//
