LOCUS NC_001475 10707 bp RNA linear VRL 11-JUL-2019
DEFINITION Dengue virus 3, complete genome.
ACCESSION NC_001475
VERSION NC_001475.2
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Dengue virus 3
ORGANISM Dengue virus 3
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
Amarillovirales; Flaviviridae; Flavivirus.
REFERENCE 1 (bases 1 to 10707)
AUTHORS Peyrefitte,C.N., Couissinier-Paris,P., Mercier-Perennec,V.,
Bessaud,M., Martial,J., Kenane,N., Durand,J.P. and Tolou,H.J.
TITLE Genetic Characterization of Newly Reintroduced Dengue Virus Type 3
in Martinique (French West Indies)
JOURNAL J. Clin. Microbiol. 41 (11), 5195-5198 (2003)
PUBMED 14605161
REFERENCE 2 (bases 1 to 10707)
AUTHORS Peyrefitte,C., Mercier,V., Couissinier-Paris,P., Tock,F.,
Kenane,N., Durand,J.-P. and Tolou,H.
TITLE Direct Submission
JOURNAL Submitted (23-APR-2002) Unite de Virologie Tropicale, IMTSSA, Parc
du Pharo, Marseille Armees, BDR 13998, France
REFERENCE 3 (bases 1 to 10707)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (01-AUG-2000) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AY099336.
On Dec 20, 2007 this sequence version replaced NC_001475.1.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..10707
/organism="Dengue virus 3"
/mol_type="genomic RNA"
/isolate="D3/H/IMTSSA-SRI/2000/1266"
/db_xref="taxon:11069"
/country="Sri Lanka"
5'UTR 1..94
stem_loop 2..69
/note="stem-loop A (SLA)"
regulatory 70..78
/regulatory_class="other"
/note="oligo U track spacer"
regulatory 79..94
/regulatory_class="ribosome_binding_site"
/note="5' upstream AUG region (UAR)"
stem_loop 79..93
/note="stem-loop B (SLB)"
gene 95..10267
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/db_xref="GeneID:5075727"
CDS 95..10267
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/codon_start=1
/product="polyprotein"
/protein_id="YP_001621843.1"
/db_xref="GeneID:5075727"
/translation="MNNQRKKTGKPSINMLKRVRNRVSTGSQLAKRFSKGLLNGQGPM
KLVMAFIAFLRFLAIPPTAGVLARWGTFKKSGAIKVLKGFKKEISNMLSIINQRKKTS
LCLMMILPAALAFHLTSRDGEPRMIVGKNERGKSLLFKTASGINMCTLIAMDLGEMCD
DTVTYKCPHITEVEPEDIDCWCNLTSTWVTYGTCNQAGEHRRDKRSVALAPHVGMGLD
TRTQTWMSAEGAWRQVEKVETWALRHPGFTILALFLAHYIGTSLTQKVVIFILLMLVT
PSMTMRCVGVGNRDFVEGLSGATWVDVVLEHGGCVTTMAKNKPTLDIELQKTEATQLA
TLRKLCIEGKITNITTDSRCPTQGEAVLPEEQDQNYVCKHTYVDRGWGNGCGLFGKGS
LVTCAKFQCLEPIEGKVVQYENLKYTVIITVHTGDQHQVGNETQGVTAEITPQASTTE
AILPEYGTLGLECSPRTGLDFNEMILLTMKNKAWMVHRQWFFDLPLPWASGATTETPT
WNRKELLVTFKNAHAKKQEVVVLGSQEGAMHTALTGATEIQNSGGTSIFAGHLKCRLK
MDKLELKGMSYAMCTNTFVLKKEVSETQHGTILIKVEYKGEDAPCKIPFSTEDGQGKA
HNGRLITANPVVTKKEEPVNIEAEPPFGESNIVIGIGDNALKINWYKKGSSIGKMFEA
TERGARRMAILGDTAWDFGSVGGVLNSLGKMVHQIFGSAYTALFSGVSWVMKIGIGVL
LTWIGLNSKNTSMSFSCIAIGIITLYLGAVVQADMGCVINWKGKELKCGSGIFVTNEV
HTWTEQYKFQADSPKRLATAIAGAWENGVCGIRSTTRMENLLWKQIANELNYILWENN
IKLTVVVGDTLGVLEQGKRTLTPQPMELKYSWKTWGKAKIVTAETQNSSFIIDGPNTP
ECPSASRAWNVWEVEDYGFGVFTTNIWLKLREVYTQLCDHRLMSAAVKDERAVHADMG
YWIESQKNGSWKLEKASLIEVKTCTWPKSHTLWTNGVLESDMIIPKSLAGPISQHNYR
PGYHTQTAGPWHLGKLELDFNYCEGTTVVITESCGTRGPSLRTTTVSGKLIHEWCCRS
CTLPPLRYMGEDGCWYGMEIRPISEKEENMVKSLVSAGSGKVDNFTMGVLCLAILFEE
VLRGKFGKKHMIAGVFFTFVLLLSGQITWRDMAHTLIMIGSNASDRMGMGVTYLALIA
TFKIQPFLALGFFLRKLTSRENLLLGVGLAMATTLQLPEDIEQMANGVALGLMALKLI
TQFETYQLWTALVSLTCSNTIFTLTVAWRTATLILAGVSLLPVCQSSSMRKTDWLPMT
VAAMGVPPLPLFIFSLKDTLKRRSWPLNEGVMAVGLVSILASSLLRNDVPMAGPLVAG
GLLIACYVITGTSADLTVEKAPDVTWEEEAEQTGVSHNLMITVDDDGTMRIKDDETEN
ILTVLLKTALLIVSGIFPYSIPATLLVWHTWQKQTQRSGVLWDVPSPPETQKAELEEG
VYRIKQQGIFGKTQVGVGVQKEGVFHTMWHVTRGAVLTHNGKRLEPNWASVKKDLISY
GGGWRLSAQWQKGEEVQVIAVEPGKNPKNFQTTPGTFQTTTGEIGAIALDFKPGTSGS
PIINREGKVVGLYGNGVVTKNGGYVSGIAQTNAEPDGPTPELEEEMFKKRNLTIMDLH
PGSGKTRKYLPAIVREAIKRRLRTLILAPTRVVAAEMEEALKGLPIRYQTTATKSEHT
GREIVDLMCHATFTMRLLSPVRVPNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAA
AIFMTATPPGTADAFPQSNAPIQDEERDIPERSWNSGNEWITDFAGKTVWFVPSIKAG
NDIANCLRKNGKKVIQLSRKTFDTEYQKTKLNDWDFVVTTDISEMGANFKADRVIDPR
RCLKPVILTDGPERVILAGPMPVTAASAAQRRGRVGRNPQKENDQYIFTGQPLNNDED
HAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRLKGESRKTFVELMRRGDL
PVWLAHKVASEGIKYTDRKWCFDGQRNNQILEENMDVEIWTKEGEKKKLRPRWLDART
YSDPLALKEFKDFAAGRKSIALDLVTEIGRVPSHLAHRTRNALDNLVMLHTSEDGGRA
YRHAVEELPETMETLLLLGLMILLTGGAMLFLISGKGIGKTSIGLICVIASSGMLWMA
EVPLQWIASAIVLEFFMMVLLIPEPEKQRTPQDNQLAYVVIGILTLAATIAANEMGLL
ETTKRDLGMSKEPGVVSPTSYLDVDLHPASAWTLYAVATTVITPMLRHTIENSTANVS
LAAIANQAVVLMGLDKGWPISKMDLGVPLLALGCYSQVNPLTLTAAVLLLITHYAIIG
PGLQAKATREAQKRTAAGIMKNPTVDGIMTIDLDSVIFDSKFEKQLGQVMLLVLCAVQ
LLLMRTSWALCEALTLATGPITTLWEGSPGKFWNTTIAVSMANIFRGSYLAGAGLAFS
IMKSVGTGKRGTGSQGETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRG
ETTHHAVSRGSAKLQWFVERNMVVPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKG
GPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTVEESRTIRV
LKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLSRNSTHEMYWISN
GTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVDLGAGTRHVNAEPETPNMDVIGERI
KRIKEEHNSTWHYDDENPYKTWAYHGSYEVKATGSASSMINGVVKLLTKPWDVVPMVT
QMAMTDTTPFGQQRVFKEKVDTRTPRPMPGTRKAMEITAEWLWRTLGRNKRPRLCTRE
EFTKKVRTNAAMGAVFTEENQWDSAKAAVEDEEFWKLVDRERELHKLGKCGSCVYNMM
GKREKKLGEFGKAKGSRAIWYMWLGARYLEFEALGFLNEDHWFSRENSYSGVEGEGLH
KLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKIIQQMDPEHRQLANAIFKL
TYQNKVVKVQRPTPTGTVMDIISRKDQRGSGQLGTYGLNTFTNMEAQLVRQMEGEGVL
TKADLENPHLLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGK
VRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGA
GWSLRETACLGKAYAQMWSLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQ
WMTTEDMLTVWNRVWIEENPWMEDKTPVTTWENVPYLGKREDQWCGSLIGLTSRATWA
QNIPTAIQQVRSLIGNEEFLDYMPSMKRFRKEEESEGAIW"
mat_peptide 95..436
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="anchored capsid protein ancC"
/protein_id="YP_001531165.2"
mat_peptide 95..394
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="capsid protein C"
/protein_id="YP_001531164.2"
misc_feature 107..436
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus capsid protein C; Region: Flavi_capsid;
pfam01003"
/db_xref="CDD:250285"
mat_peptide 437..934
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="membrane glycoprotein precursor prM"
/note="premembrane/membrane protein"
/protein_id="YP_001531166.1"
mat_peptide 437..709
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="protein pr"
/note="peptide pr"
/protein_id="YP_009164955.1"
misc_feature 470..706
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus polyprotein propeptide; Region:
Flavi_propep; pfam01570"
/db_xref="CDD:279856"
mat_peptide 710..934
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="membrane glycoprotein M"
/note="protein M"
/protein_id="YP_001531167.1"
misc_feature 713..934
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus envelope glycoprotein M; Region:
Flavi_M; pfam01004"
/db_xref="CDD:279358"
mat_peptide 935..2413
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="envelope protein E"
/note="protein E"
/protein_id="YP_001531168.2"
misc_feature 938..1816
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus glycoprotein, central and dimerization
domains; Region: Flavi_glycoprot; pfam00869"
/db_xref="CDD:279241"
misc_feature 1820..2107
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus glycoprotein, immunoglobulin-like
domain; Region: Flavi_glycop_C; pfam02832"
/db_xref="CDD:280922"
misc_feature 2123..2413
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="flavivirus envelope glycoprotein E, stem/anchor
domain; Region: flavi_E_stem; TIGR04240"
/db_xref="CDD:213897"
mat_peptide 2414..3469
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="nonstructural protein NS1"
/protein_id="YP_001531169.2"
misc_feature 2420..3478
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus non-structural Protein NS1; Region:
Flavi_NS1; pfam00948"
/db_xref="CDD:279316"
mat_peptide 3470..4123
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="nonstructural protein NS2A"
/protein_id="YP_001531170.2"
misc_feature 3500..4048
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus non-structural protein NS2A; Region:
Flavi_NS2A; pfam01005"
/db_xref="CDD:279359"
mat_peptide 4124..4513
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="nonstructural protein NS2B"
/protein_id="YP_001531171.3"
misc_feature 4133..4513
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus non-structural protein NS2B; Region:
Flavi_NS2B; pfam01002"
/db_xref="CDD:279357"
mat_peptide 4514..6370
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="nonstructural protein NS3"
/protein_id="YP_001531172.2"
misc_feature 4574..5014
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Peptidase S7, Flavivirus NS3 serine protease;
Region: Peptidase_S7; pfam00949"
/db_xref="CDD:279317"
misc_feature 5054..5491
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="DEAD-like helicases superfamily; Region: DEXDc;
smart00487"
/db_xref="CDD:214692"
misc_feature 5069..5506
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus DEAD domain; Region: Flavi_DEAD;
pfam07652"
/db_xref="CDD:284962"
misc_feature 5102..5116
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:238005"
misc_feature 5366..5377
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="putative Mg++ binding site [ion binding]; other
site"
/db_xref="CDD:238005"
misc_feature 5627..5905
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="helicase superfamily c-terminal domain; Region:
HELICc; smart00490"
/db_xref="CDD:197757"
misc_feature order(5762..5764,5882..5884,5894..5896,5903..5905)
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="ATP-binding site [chemical binding]; other site"
/db_xref="CDD:238034"
mat_peptide 6371..6751
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="nonstructural protein NS4A"
/protein_id="YP_001531173.2"
misc_feature 6383..6814
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus non-structural protein NS4A; Region:
Flavi_NS4A; pfam01350"
/db_xref="CDD:279666"
mat_peptide 6752..6820
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="protein 2K"
/note="presumably plays a role in membrane rearrangement"
/protein_id="YP_001531174.2"
mat_peptide 6821..7564
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="nonstructural protein NS4B"
/protein_id="YP_001531175.2"
misc_feature 6821..7543
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus non-structural protein NS4B; Region:
Flavi_NS4B; pfam01349"
/db_xref="CDD:279665"
mat_peptide 7565..10264
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/product="RNA-dependent RNA polymerase NS5"
/protein_id="YP_001531176.2"
misc_feature 7727..8233
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="FtsJ-like methyltransferase; Region: FtsJ;
pfam01728"
/db_xref="CDD:279986"
misc_feature 8312..10231
/gene="POLY"
/locus_tag="DV3_gp1"
/gene_synonym="polyprotein gene"
/note="Flavivirus RNA-directed RNA polymerase; Region:
Flavi_NS5; pfam00972"
/db_xref="CDD:279336"
stem_loop 114..130
/note="capsid region hairpin (cHP)"
regulatory 132..142
/regulatory_class="other"
/note="5' conserved sequence (CS); also called cyclization
sequence"
3'UTR 10268..10707
ncRNA 10290..10707
/ncRNA_class="lncRNA"
/product="sfRNA1"
/note="subgenomic flavivirus RNA"
stem_loop 10294..10359
/note="flaviviral nuclease-resistant RNA 1 (fNR1); also
called stem-loop 1 or xrRNA1"
ncRNA 10366..10707
/ncRNA_class="lncRNA"
/product="sfRNA2"
/note="subgenomic flavivirus RNA"
stem_loop 10370..10432
/note="flaviviral nuclease-resistant RNA 2 (fNR2); also
called stem-loop 2 or xrRNA2"
ncRNA 10436..10707
/ncRNA_class="lncRNA"
/product="sfRNA3"
/note="subgenomic flavivirus RNA"
stem_loop 10440..10552
/note="dumbbell 1 (DBI); also called xrRNA3"
ncRNA 10524..10707
/ncRNA_class="lncRNA"
/product="sfRNA4"
/note="subgenomic flavivirus RNA"
stem_loop 10524..10605
/note="dumbbell 2 (DBII); also called xrRNA4"
regulatory 10602..10612
/regulatory_class="other"
/note="3' conserved sequence (CS); also called cyclization
sequence"
stem_loop 10615..10628
/note="short hairpin (sHP)"
regulatory 10626..10642
/regulatory_class="promoter"
/note="3' upstream AUG region (UAR)"
stem_loop 10629..10707
/note="3' stem-loop (3'SL)"
ORIGIN
1 agttgttagt ctacgtggac cgacaagaac agtttcgact cggaagcttg cttaacgtag
61 tgctgacagt tttttattag agagcagatc tctgatgaac aaccaacgga agaagacggg
121 aaaaccgtct atcaatatgc tgaaacgcgt gagaaaccgt gtgtcaactg gatcacagtt
181 ggcgaagaga ttctcaaaag gactgctgaa cggccaggga ccaatgaaat tggttatggc
241 gttcatagct ttcctcagat ttctagccat tccaccaaca gcaggagtct tggctagatg
301 gggaaccttc aagaagtcgg gggccattaa ggtcctgaaa ggcttcaaga aggagatctc
361 aaacatgctg agcataatca accaacggaa aaagacatcg ctctgtctca tgatgatatt
421 gccagcagca cttgctttcc acttgacttc acgagatgga gagccgcgca tgattgtggg
481 gaagaatgaa agaggtaaat ccctactttt taagacagcc tctggaatca acatgtgcac
541 actcatagcc atggatttgg gagagatgtg tgatgacacg gtcacttaca aatgccccca
601 cattaccgaa gtggaacctg aagacattga ctgctggtgc aaccttacat caacatgggt
661 gacttatgga acgtgcaatc aagctggaga gcatagacgc gacaagagat cagtggcgtt
721 agctccccat gtcggcatgg gactggacac acgcacccaa acctggatgt cggctgaagg
781 agcttggaga caagtcgaga aggtagagac atgggccctt aggcacccag ggttcaccat
841 actagcccta tttctcgccc attacatagg cacttccctg acccagaagg tggttatttt
901 catattatta atgctggtca ccccatccat gacaatgaga tgtgtgggag taggaaacag
961 agattttgtg gaagggctat caggagctac gtgggttgac gtggtgctcg agcacggggg
1021 gtgtgtgact accatggcta agaacaagcc cacgctggat atagagcttc agaagaccga
1081 ggccacccaa ctggcgaccc taaggaagct atgcattgag gggaaaatta ccaacataac
1141 aactgactca agatgtccta cccaagggga agcggttttg cctgaggagc aggaccagaa
1201 ctacgtgtgt aagcatacat acgtagacag aggttggggg aacggttgtg gtttgtttgg
1261 caaaggaagc ttggtaacat gtgcgaaatt tcaatgcctg gaaccaatag agggaaaagt
1321 ggtgcaatat gagaacctca aatacaccgt catcattaca gtgcacacag gagaccaaca
1381 ccaggtggga aatgaaacgc aaggagtcac ggctgagata acacctcagg catcaaccac
1441 tgaagccatc ttgcctgaat atggaaccct tgggctagaa tgctcaccac ggacaggttt
1501 ggatttcaat gaaatgatct tactaacaat gaagaacaaa gcatggatgg tacatagaca
1561 atggttcttt gacctacctc taccatgggc atcaggagct acaacagaaa caccaacctg
1621 gaacaggaag gagcttcttg tgacattcaa aaacgcacat gcgaaaaaac aagaagtagt
1681 tgtccttgga tcgcaagagg gagcaatgca taccgcactg acaggagcta cagaaatcca
1741 aaactcagga ggcacaagca ttttcgcggg gcacttaaaa tgtagactta agatggacaa
1801 attggaactc aaggggatga gctatgcaat gtgcacgaat acctttgtgt tgaagaaaga
1861 agtctcagaa acgcagcacg ggacaatact cattaaggtt gagtacaaag gggaagatgc
1921 accttgcaag attccctttt ccacagagga tggacaaggg aaagctcata atggcagact
1981 gatcacagcc aaccctgtgg tgactaagaa ggaggagcct gtcaatattg aggctgaacc
2041 tccttttggg gaaagcaata tagtaattgg aattggagac aacgccttga aaatcaactg
2101 gtacaagaag gggagctcga ttgggaagat gttcgaggcc actgaaaggg gtgcaaggcg
2161 catggccatc ttgggagaca cagcttggga ctttggatca gtgggtggtg ttctgaactc
2221 attaggcaaa atggtgcacc aaatatttgg aagtgcttat acagccctgt tcagtggagt
2281 ctcttgggtg atgaaaattg gaataggtgt cctcttgact tggatagggt tgaattcaaa
2341 aaacacatcc atgtcatttt catgcattgc gataggaatc attacactct atctgggagc
2401 tgtggtacaa gctgacatgg ggtgtgtcat aaactggaag ggcaaagaac tcaaatgtgg
2461 aagcggaatt ttcgtcacca atgaggtcca tacctggaca gagcaataca aattccaagc
2521 agactcccca aaaagattgg caacagccat tgcaggcgcc tgggagaatg gagtgtgtgg
2581 aattaggtca acaaccagaa tggagaatct cttgtggaag caaatagcca atgaactgaa
2641 ctacatatta tgggaaaaca atatcaaatt aacggtagtt gtgggcgata cacttggggt
2701 cttagagcaa gggaaaagaa cactaacacc acaacccatg gagctaaaat actcatggaa
2761 aacgtgggga aaggcaaaaa tagtgacagc tgaaacacaa aattcctctt tcataataga
2821 cgggccaaac acaccggagt gtccaagtgc ctcaagagca tggaatgtgt gggaggtgga
2881 agattacggg ttcggagtct tcacaaccaa catatggctg aaactccgag aggtctacac
2941 ccaactatgt gaccataggc taatgtcggc agctgtcaag gatgagaggg ccgtgcatgc
3001 cgacatgggc tactggatag aaagccaaaa gaatggaagt tggaagctag aaaaagcatc
3061 cctcatagag gtaaaaacct gcacatggcc aaaatcacac actctctgga ctaatggtgt
3121 gctagagagt gacatgatca tcccaaagag tctagctggt cctatctcac aacacaacta
3181 caggcccggg taccacaccc aaacggcagg accctggcac ttaggaaaat tggagctgga
3241 cttcaactac tgtgaaggaa caacagttgt catcacagaa agctgtggga caagaggccc
3301 atcattgaga acaacaacag tgtcagggaa gttgatacac gaatggtgtt gccgctcgtg
3361 cacacttccc cccctgcgat acatgggaga agacggctgc tggtatggca tggaaatcag
3421 acccatcagt gagaaagaag agaacatggt aaagtcttta gtctcagcgg gaagtggaaa
3481 ggtggacaac ttcacaatgg gtgtcttgtg tttggcaatc ctctttgaag aggtgttgag
3541 aggaaaattt gggaagaaac acatgattgc aggggttttc tttacgtttg tgctccttct
3601 ctcagggcaa ataacatgga gagacatggc gcacacacta ataatgatcg ggtccaacgc
3661 ctctgacagg atgggaatgg gcgtcaccta cctagctcta attgcaacat ttaaaatcca
3721 gccattcttg gctttgggat ttttcctaag aaagctgaca tctagagaaa atttattgtt
3781 aggagttggg ttggccatgg caacaacgtt acaactgcca gaggacattg aacaaatggc
3841 aaatggagtc gctctggggc tcatggctct taaactgata acacaatttg aaacatacca
3901 attgtggacg gcattagtct ccttaacgtg ttcaaacaca atttttacgt tgactgttgc
3961 ctggagaaca gccactctga ttttggccgg agtttcgctt ttaccagtgt gccagtcttc
4021 aagcatgagg aaaacagatt ggctcccaat gacagtggca gctatgggag ttccacccct
4081 tccacttttt atttttagct tgaaagacac actcaaaagg agaagctggc cactgaatga
4141 aggggtgatg gctgttgggc ttgtgagcat tctggccagt tctctcctta gaaatgatgt
4201 gcccatggct ggaccattag tggccggggg cttgctgata gcgtgctacg tcataactgg
4261 cacgtcagcg gacctcactg tagaaaaagc cccagatgta acatgggagg aagaggctga
4321 gcagacagga gtgtcccaca acttaatgat cacagttgat gatgatggaa caatgagaat
4381 aaaagatgat gagactgaga acatcctaac agtgctttta aaaacagcat tactaatagt
4441 atcaggcatt tttccatact ccatacccgc aacattgttg gtctggcaca cttggcaaaa
4501 acaaacccaa agatccggcg ttttatggga cgtacccagc cccccagaga cacagaaagc
4561 agaactggaa gaaggggttt ataggatcaa acagcaagga atttttggga aaacccaagt
4621 aggggttgga gtacagaaag aaggagtctt ccacaccatg tggcacgtca caagaggggc
4681 agtgttgaca cataatggga aaagactgga accaaactgg gctagtgtga aaaaagatct
4741 gatttcatat ggaggaggat ggagactgag cgcacaatgg caaaaggggg aggaggtgca
4801 ggttattgcc gtagagccag ggaagaaccc aaagaacttt caaaccacgc caggcacttt
4861 ccagactact acaggggaaa taggagcaat tgcactggat ttcaagcctg gaacttcagg
4921 atctcctatc ataaatagag agggaaaggt agtgggactg tatggcaatg gagtggttac
4981 aaagaatggt ggctatgtca gcggaatagc gcaaacaaat gcagaaccag atggaccgac
5041 accagagttg gaagaagaga tgttcaaaaa gcgaaacctg accataatgg atcttcatcc
5101 tgggtcagga aagacacgga aataccttcc agctattgtc agagaggcaa tcaagagacg
5161 tttaagaacc ttaattttgg caccgacaag ggtggttgca gctgagatgg aagaagcatt
5221 gaaagggctc ccaataaggt accaaacaac agcaacaaaa tctgaacaca caggaagaga
5281 gattgttgat ctaatgtgcc acgcaacgtt cacaatgcgt ttgctgtcac cagttagggt
5341 tccaaattac aacttgataa taatggatga ggcccatttc acagacccag ccagtatagc
5401 ggctagaggg tacatatcaa ctcgtgttgg aatgggagag gcagccgcaa tcttcatgac
5461 agcaacaccc cctggaacag ctgatgcctt tcctcagagc aacgctccaa ttcaagatga
5521 agaaagggac ataccagaac gctcatggaa ttcaggcaat gaatggatta ccgacttcgc
5581 tgggaaaacg gtgtggtttg tccctagcat taaagccgga aatgacatag caaactgctt
5641 gcgaaaaaac gggaaaaaag tcattcaact tagtaggaag acttttgaca cagaatatca
5701 gaagactaaa ctgaatgatt gggactttgt ggtgacaact gacatttcag aaatgggggc
5761 caatttcaaa gcagatagag tgatcgaccc aagaagatgt ctcaaaccag tgatcttgac
5821 agatggacca gagcgggtga tcctggccgg accaatgcca gtcaccgcgg cgagtgctgc
5881 gcaaaggaga gggagagttg gcaggaaccc acaaaaagag aatgaccagt acatattcac
5941 gggccagcct ctcaacaatg atgaagacca tgctcactgg acagaagcaa aaatgctgct
6001 ggacaacatc aacacaccag aagggattat accagctctc tttgaaccag aaagggagaa
6061 gtcagccgcc atagacggtg agtatcgcct gaagggtgag tccaggaaga ctttcgtgga
6121 actcatgagg aggggtgacc ttccagtttg gttagcccat aaagtagcat cagaaggaat
6181 caaatacaca gatagaaaat ggtgctttga tgggcaacgc aataatcaaa ttttagagga
6241 gaacatggat gtggaaattt ggacaaagga aggagaaaag aaaaaattga gacctaggtg
6301 gcttgatgcc cgcacttatt cagatccatt ggcactcaag gaattcaagg actttgcggc
6361 tggcagaaag tcaatcgccc ttgatcttgt gacagaaata ggaagagtgc cttcacatct
6421 agcccacaga acaagaaacg ctctggacaa tctggtgatg ctgcatacgt cagaagatgg
6481 cggtagggct tacaggcatg cggtggagga actaccagaa acaatggaaa cactcctact
6541 cttgggacta atgatcttgt tgacaggtgg agcaatgctt ttcttgatat caggtaaagg
6601 gattggaaag acttcaatag gactcatttg tgtaatcgct tccagcggca tgttgtggat
6661 ggccgaagtt ccactccaat ggatcgcgtc ggctatagtc ctggagtttt ttatgatggt
6721 gttgctcata ccagaaccag aaaagcagag aaccccccaa gacaaccaac tcgcatatgt
6781 cgtgataggc atacttacat tggctgcaac aatagcagcc aatgaaatgg gactgctgga
6841 aaccacaaag agagacttag gaatgtctaa ggagccaggt gttgtttctc caaccagcta
6901 tttggatgtg gacttgcacc cagcatcagc ctggacattg tacgccgtgg ccactacagt
6961 aataacacca atgttaagac ataccataga gaattctaca gcaaatgtgt ccctggcagc
7021 tatagccaac caggcagtgg tcctgatggg tttggacaaa ggatggccaa tatcaaaaat
7081 ggacttaggc gtgccactac tggcactggg ttgctattca caagtgaacc cactgactct
7141 aactgcggca gtacttttgc taatcacaca ttatgctatc ataggtccag gattgcaagc
7201 aaaagccacc cgtgaagctc agaaaaggac agctgctgga ataatgaaga atccaacagt
7261 ggatgggata atgacaatag acctagattc tgtaatattt gattcaaaat ttgaaaaaca
7321 actgggacag gttatgctcc tggttttgtg cgcagtccaa ctcttgctaa tgagaacatc
7381 atgggccttg tgtgaagctt taactctagc tacaggacca ataacaacac tctgggaagg
7441 atcacctggt aagttctgga acaccacgat agctgtttcc atggcgaaca tttttagagg
7501 gagctattta gcaggagctg ggcttgcttt ttctattatg aaatcagttg gaacaggaaa
7561 aagaggaaca ggctcacaag gtgaaacttt aggagaaaaa tggaaaaaga aattaaatca
7621 attatcccgg aaagagtttg acctttacaa gaaatctgga atcactgaag tggatagaac
7681 agaagccaaa gaagggttga aaagaggaga gacaacacat catgccgtgt cccgaggtag
7741 cgcaaaactt caatggtttg tggaaagaaa catggtcgtt cccgaaggaa gagtcataga
7801 cttgggctgt ggaagaggag gctggtcata ttactgtgca ggactgaaaa aagtcacaga
7861 agtgcgagga tacacaaaag gcggtccagg acacgaagaa ccagtaccta tgtctacata
7921 tggatggaac atagttaagt taatgagcgg aaaggatgtg ttctatctcc cacctgaaaa
7981 gtgtgatacc ctgttgtgtg acattggaga atcttcacca agcccaacag tggaagagag
8041 cagaactata agagttttga agatggttga accatggcta aaaaacaacc agttttgcat
8101 taaagttttg aacccttaca tgccaactgt gattgagcac ctagaaagac tacaaaggaa
8161 acatggagga atgcttgtga gaaatccact ttcacgaaac tccacgcacg aaatgtactg
8221 gatatctaat ggcacaggta acattgtctc ttcagtcaac atggtgtcta gattgctact
8281 gaacaggttc acgatgacac acaggagacc caccatagag aaagatgtgg atttaggagc
8341 aggaactcga catgttaatg cggaaccaga aacacccaac atggatgtca ttggggaaag
8401 aataaaaagg atcaaggagg agcataattc aacatggcac tatgatgacg aaaaccccta
8461 caaaacgtgg gcttaccatg gatcctatga agtcaaagcc acaggctcag cctcctccat
8521 gataaatgga gtcgtgaaac tcctcaccaa accatgggat gtggtgccca tggtgacaca
8581 gatggcaatg acagacacaa ctccatttgg ccagcagaga gtctttaaag agaaagtgga
8641 caccaggacg cccaggccca tgccagggac aagaaaggct atggagatca cagcggagtg
8701 gctctggaga accctgggaa ggaacaaaag acccagatta tgcacaaggg aagagtttac
8761 aaaaaaggtc agaactaacg cagccatggg cgccgttttc acagaggaga accaatggga
8821 cagtgcgaaa gctgctgttg aggatgaaga attttggaaa cttgtggaca gagaacgtga
8881 actccacaaa ttgggcaaat gtggaagctg cgtttataac atgatgggca agagagagaa
8941 aaaacttgga gagtttggca aagcaaaagg cagtagagct atatggtaca tgtggttggg
9001 agccaggtac cttgagttcg aagcccttgg attcttaaat gaagaccact ggttctcgcg
9061 tgaaaactct tacagtggag tagaaggaga aggactgcac aagctaggct acatattaag
9121 ggacatttcc aagatacccg gaggagccat gtatgctgat gacacagctg gttgggacac
9181 aagaataaca gaagatgacc tgcacaatga ggaaaagatc atacagcaaa tggaccctga
9241 acacaggcag ttagcgaacg ctatattcaa gctcacatac caaaacaaag tggtcaaagt
9301 tcaacgaccg actccaacgg gcacggtaat ggatattata tctaggaaag accaaagggg
9361 cagtggacaa ctgggaactt atggcctgaa tacattcacc aacatggaag cccagttagt
9421 cagacaaatg gaaggagaag gtgtgctgac aaaggcagac ctcgagaacc ctcatctgct
9481 agagaagaaa atcacacaat ggttggaaac caaaggagtg gagaggttaa aaagaatggc
9541 cattagcggg gatgattgcg tggtgaaacc aatcgatgac aggttcgcta atgccctgct
9601 tgctttgaac gatatgggaa aggttcggaa agacatacct caatggcagc catcaaaggg
9661 atggcatgat tggcaacagg ttcctttctg ctcccaccac tttcatgaat tgatcatgaa
9721 agatggaaga aagttggtgg ttccctgcag accccaggac gaactaatag gaagagcaag
9781 aatctctcaa ggagcgggat ggagccttag agaaactgca tgtctgggga aagcctacgc
9841 ccaaatgtgg agtctcatgt attttcacag aagagatctc agattagcat ccaacgccat
9901 atgttcagca gtaccagtcc actgggttcc cacaagtaga acgacatggt ctattcatgc
9961 tcaccatcag tggatgacta cagaagacat gcttactgtt tggaacaggg tgtggataga
10021 ggaaaatcca tggatggaag acaaaactcc agttacaact tgggaaaatg ttccatatct
10081 aggaaagaga gaagaccaat ggtgtggatc acttattggt ctcacttcca gagcaacctg
10141 ggcccagaac atacccacag caattcaaca ggtgagaagc cttataggca atgaagagtt
10201 cctggactac atgccttcaa tgaagagatt caggaaggaa gaggagtcgg agggagccat
10261 ttggtaaacg taggaagtgg aaaagaggct aactgtcagg ccaccttaag ccacagtacg
10321 gaagaagctg tgctgcctgt gagccccgtc caaggacgtt aaaagaagaa gtcaggcccc
10381 aaagccacgg tttgagcaaa ccgtgctgcc tgtagctccg tcgtggggac gtaaaacctg
10441 ggaggctgca aactgtggaa gctgtacgca cggtgtagca gactagcggt tagaggagac
10501 ccctcccatg acacaacgca gcagcggggc ccgagcactg agggaagctg tacctccttg
10561 caaaggacta gaggttagag gagacccccc gcaaataaaa acagcatatt gacgctggga
10621 gagaccagag atcctgctgt ctcctcagca tcattccagg cacagaacgc cagaaaatgg
10681 aatggtgctg ttgaatcaac aggttct
//
