LOCUS       NC_001653               1682 bp ss-RNA     circular VRL 12-APR-2023
DEFINITION  Hepatitis delta virus, complete genome.
ACCESSION   NC_001653
VERSION     NC_001653.2
DBLINK      BioProject: PRJNA485481
KEYWORDS    RefSeq.
SOURCE      Hepatitis delta virus
  ORGANISM  Hepatitis delta virus
            Viruses; Ribozyviria; Kolmioviridae; Deltavirus.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Saldanha,J.A., Thomas,H.C. and Monjardino,J.P.
  TITLE     Cloning and sequencing of RNA of hepatitis delta virus isolated
            from human serum
  JOURNAL   J. Gen. Virol. 71 (PT 7), 1603-1606 (1990)
   PUBMED   2374010
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Makino,S., Chang,M.F., Shieh,C.K., Kamahora,T., Vannier,D.M.,
            Govindarajan,S. and Lai,M.M.
  TITLE     Molecular cloning and sequencing of a human hepatitis delta (delta)
            virus RNA
  JOURNAL   Nature 329 (6137), 343-346 (1987)
   PUBMED   3627276
REFERENCE   3  (bases 1 to 1682)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (03-SEP-2004) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D01075.
            
            On Mar 12, 2001 this sequence version replaced NC_001653.1.
            Annotation based on that found in PMID: 3627276, PMID: 2374010 and
            AF104264.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Hepatitis delta virus"
                     /mol_type="genomic RNA"
                     /db_xref="taxon:12475"
                     /clone="D380, D600, D75, D280, D54, D4, D20, D33, D69,
                     462b, 702b, 572c, 772c, 462c"
                     /note="HindIII site of chimpanzee-derived HDV RNA;
                     isolated from human serum;
                     synonym: Hepatitis D virus"
     misc_feature    153..157
                     /note="viroid consensus sequence"
     misc_feature    685..686
                     /note="self-splicing site"
     misc_feature    735..755
                     /note="palindromic sequence"
     misc_feature    complement(784..785)
                     /note="self-splicing site"
     misc_feature    942..946
                     /note="viroid consensus sequence"
     gene            complement(956..1600)
                     /gene="L-HDAg"
                     /locus_tag="HDvgp1"
                     /db_xref="GeneID:920836"
     CDS             complement(956..1600)
                     /gene="L-HDAg"
                     /locus_tag="HDvgp1"
                     /note="RNA editing"
                     /codon_start=1
                     /transl_except=(pos:complement(1013..1015),aa:Trp)
                     /product="large delta antigen"
                     /protein_id="NP_597693.2"
                     /db_xref="GeneID:920836"
                     /translation="MSRPEGRKNRGGREEVLEQWVSGRKKLEELERDLRKVKKKIKKL
                     EDEHPWLGNIKGILGKKDKDGEGAPPAKRARTDQMEVDSGPRKRPSRGGFTDKERQDH
                     RRRKALENKRKQLSAGGKNLSKEEEEELRRLTEEDERRERRIAGPQVGGVNPLEGGTR
                     GAPGGGFVPSMQGVPESPFTRTGEGLDIRGSQGFPWDILFPADPPSSPQSCRPQ"
     misc_feature    complement(1079..1597)
                     /gene="L-HDAg"
                     /locus_tag="HDvgp1"
                     /note="Hepatitis delta virus delta antigen; Region:
                     HDV_ag; pfam01517"
                     /db_xref="CDD:426302"
     gene            complement(1013..1600)
                     /gene="S-HDAg"
                     /locus_tag="HDvgp2"
                     /db_xref="GeneID:920835"
     CDS             complement(1013..1600)
                     /gene="S-HDAg"
                     /locus_tag="HDvgp2"
                     /note="small delta antigen"
                     /codon_start=1
                     /product="delta antigen"
                     /protein_id="NP_077804.1"
                     /db_xref="GeneID:920835"
                     /translation="MSRPEGRKNRGGREEVLEQWVSGRKKLEELERDLRKVKKKIKKL
                     EDEHPWLGNIKGILGKKDKDGEGAPPAKRARTDQMEVDSGPRKRPSRGGFTDKERQDH
                     RRRKALENKRKQLSAGGKNLSKEEEEELRRLTEEDERRERRIAGPQVGGVNPLEGGTR
                     GAPGGGFVPSMQGVPESPFTRTGEGLDIRGSQGFP"
     misc_feature    complement(1079..1597)
                     /gene="S-HDAg"
                     /locus_tag="HDvgp2"
                     /note="Hepatitis delta virus delta antigen; Region:
                     HDV_ag; pfam01517"
                     /db_xref="CDD:426302"
     misc_feature    1478..1483
                     /note="viroid consensus sequence"
ORIGIN      
        1 atgagccaag ttccgaacaa ggattcgcgg ggaggataga tcagcgcccg agaggggtga
       61 gtcggtaaag agcattggaa cgtcggagat acaactccca agaaggaaaa aagagaaagc
      121 aagaagcgga tgaatttccc cataacgcca gtgaaactct aggaagggga aagagggaag
      181 gtggaagaga aggaggcggg cctcccgatc cgaggggccc ggcggccaag tttggaggac
      241 actccggccc gaagggttga gagtacccca gagggaggaa gccacacgga gtagaacaga
      301 gaaatcacct ccagaggacc ccttcagcga acagagagcg catcgcgaga gggagtagac
      361 catagcgata ggaggggatg ctaggagttg ggggagaccg aagcgaggag gaaagcaaag
      421 agagcagcgg ggctagcagg tgggtgttcc gccccccgag aggggacgag tgaggcttat
      481 cccggggaac tcgacttatc gtccccacat agcagactcc cggaccccct ttcaaagtga
      541 ccgagggggg tgactttgaa cattggggac cagtggagcc atgggatgct cctcccgatt
      601 ccgcccaagc tccttccccc caagggtcgc ccaggaatgg cgggacccca ctctgcaggg
      661 tccgcgttcc atcctttctt acctgatggc cggcatggtc ccagcctcct cgctggcgcc
      721 ggctgggcaa cattccgagg ggaccgtccc ctcggtaatg gcgaatggga cccacaaatc
      781 tctctagctt cccagagaga agcgagagaa aagtggctct cccttagcca tccgagtgga
      841 cgtgcgtcct ccttcggatg cccaggtcgg accgcgagga ggtggagatg ccatgccgac
      901 ccgaagagga aagaaggacg cgagacgcaa acctgcgagt ggaaacccgc tttattcact
      961 ggggtcgaca actctgggga gaggagggag ggtcggctgg gaagagtata tcctatggga
     1021 atccctggct tccccttatg tccagtccct ccccggtccg agtaaagggg gactccggga
     1081 ctccttgcat gctggggacg aagccgcccc cgggcgctcc cctcgttcca ccttcgaggg
     1141 ggttcacacc cccaacctgc gggccggcta ttcttctttc ccttctctcg tcttcctcgg
     1201 tcaacctcct aagttcctct tcctcctcct tgctgaggtt ctttcccccc gccgatagct
     1261 gctttctctt gttctcgagg gccttccttc gtcggtgatc ctgcctctcc ttgtcggtga
     1321 atcctcccct ggaaggcctc ttcctaggtc cggagtctac ttccatctgg tccgttcggg
     1381 ccctcttcgc cgggggagcc ccctctccat ccttatcttt ctttccgaga attcctttga
     1441 tgtttcccag ccagggatgt tcatcctcaa gtttcttgat tttcttctta accttccgga
     1501 ggtctctctc gagttcctct aacttctttc ttccgctcac ccactgctcg agaacctctt
     1561 ctctcccccc gcggtttttc cttccttcgg gccggctcat cttcgactag aggcgacggt
     1621 cctcagtact cttactcttt tctgtaaaga ggagactgct ggccctgtcg cccaagttcg
     1681 ag
//