LOCUS NC_001693 7313 bp DNA linear VRL 13-AUG-2018
DEFINITION Human papillomavirus type 60, complete genome.
ACCESSION NC_001693
VERSION NC_001693.1
DBLINK Project: 14028
KEYWORDS RefSeq.
SOURCE Human papillomavirus type 60
ORGANISM Human papillomavirus type 60
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
Papovaviricetes; Zurhausenvirales; Papillomaviridae;
Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 4.
REFERENCE 1 (sites)
AUTHORS Matsukura,T., Iwasaki,T. and Kawashima,M.
TITLE Molecular cloning of a novel human papillomavirus (type 60) from a
plantar cyst with characteristic pathological changes
JOURNAL Virology 190 (1), 561-564 (1992)
PUBMED 1326820
REFERENCE 2 (bases 1 to 7313)
AUTHORS Delius,H.
TITLE Sequenced by Hajo Delius, Deutsches Krebsforschungzentrum,
Angewandte Tumorvirologie, I.N.F. 506, W-6900 Heidelberg, Germany
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 7313)
AUTHORS Farmer,A.D.
TITLE Direct Submission
JOURNAL Submitted (18-JUL-1995) Andrew D. Farmer, HIV Sequence Database,
Los Alamos National Labroatory, T-10, Mail Stop K710, Los Alamos,
NM 87501, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to U31792.
HPV60 was originally isolated from a keratinous plantar cyst
composed of the wall of the squamous cell layer and the horny inner
substance in the lower dermis displaying cytoplasmic amorphous
eosinophilic inclusions and vacuolated structure with or without
pyknotic nuclei. These morphological changes are not characteristic
of skin lesions associated with other HPV types (1, 2, 3, 4, and
7). HPV 60 was found in three out of three other plantar cysts with
similar pathological changes; a fourth cyst without the associated
pathological changes as negative for HPV60. These results strongly
suggest that HPV 60 has unique biological properties which can
induce a plantar cyst. The HPV60 genome appeared to be in an
episomal form. HPV 60 showed no similarity with other known
prototypes (HPVs 1-59) by Southern blot analysis under stringent
conditions. Phylogenetically, it is associated with HPV 4, 48, 50,
and 65, a group of primarily cutaneous types.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..7313
/organism="Human papillomavirus type 60"
/mol_type="genomic DNA"
/db_xref="taxon:40540"
/note="cloned HPV-60 DNA was obtained from the
Papillomavirus Reference Center, Heidelberg and sequenced
by Dr. H. Delius"
gene 102..530
/gene="E6"
/db_xref="GeneID:1403638"
CDS 102..530
/gene="E6"
/note="putative"
/codon_start=1
/product="transforming protein E6"
/protein_id="NP_043437.1"
/db_xref="GeneID:1403638"
/translation="MQMEEDRFPTTVADYCSEFDIPLKDLKLKCVFCRFYLTEQQLAA
FYIKNLKLVWKNRYCFACCTPCLRLTAKFEAENYFQCMCKGEVLEVLTRIPLSSLSVR
CFDCLTLLSFAEKIDCIISGQNFYLVRGRWRSYCRNCIEK"
misc_feature 189..518
/gene="E6"
/note="Early Protein (E6); Region: E6; cl27673"
/db_xref="CDD:452769"
gene 527..817
/gene="E7"
/db_xref="GeneID:1403639"
CDS 527..817
/gene="E7"
/note="putative"
/codon_start=1
/product="transforming protein E7"
/protein_id="NP_043438.1"
/db_xref="GeneID:1403639"
/translation="MIGNQPNVNNLDVNLEELVLPVSLLADEELSPDGDPEEEEHYPY
TIDTCCKPCGAGVRFTIIATPSAVITLRQLLLQEVFLTCLRCSRSLFRHGRS"
misc_feature 533..784
/gene="E7"
/note="E7 protein, Early protein; Region: E7; cl02891"
/db_xref="CDD:295537"
gene 804..2636
/gene="E1"
/db_xref="GeneID:1403640"
CDS 804..2636
/gene="E1"
/note="putative"
/codon_start=1
/product="replication protein E1"
/protein_id="NP_043439.1"
/db_xref="GeneID:1403640"
/translation="MADPNKGINSLELNEGHSEWYVVTEAECINSLDTMEELFEESTD
GSIVSNLIDDSEELEEGNSLALYNEQLTEDCNRAILALKRKLTKTPLKSQDRTVADLS
PRLEAVTISPQRQSKRRLFEDSGLGEDEATNSIEKKVVSNSLESNESGTLVVETDSIF
RSTNRKATLLAKFKEYFGVAYGDLTRPFKSDRSCCENWVISVCAAAEEVIEASKTVMQ
QHCDFLQVISYGFYALYLVKFKTAKSRDTIMKLFSLTLNVQEQQLMCDPPKSRSTPTA
LYFYRRSFGNASFIYGPFPDWLAKLTMLDHESAASSEQFELAQMIQFAYDNNLTTESE
IAYKYALLADSDANAAAFLKSNQQVKYVRDCYAMLRYYKRQEMKDMSISEWIWKCCDD
CNQEGNWKLIAQFLRYQEVNFISFLCALKTLFKGIPKRNCLVFWGPPDTGKSYICSSL
TRFMQGKVVSFMNRHSQFWLQPLQDCKLGFLDDATFQCWQYMDVNMRNALDGNHISLD
LKHKAPLQIKLPPLLITTNVDVENEASLMYLKSRLVFFKFPNKLPLKENDEVLYEITD
ASWKCFFIKFASHLELTARGDEQHESGRSDRAFRCTAGTNTESI"
misc_feature 804..2633
/gene="E1"
/note="E1; Provisional; Region: PHA02774"
/db_xref="CDD:222927"
gene 2572..3786
/gene="E2"
/db_xref="GeneID:1403641"
CDS 2572..3786
/gene="E2"
/note="putative"
/codon_start=1
/product="regulatory protein E2"
/protein_id="NP_043440.1"
/db_xref="GeneID:1403641"
/translation="MNQADLTERSDALQEQILNLYEQDSKDIQAQIQYWDLNRKLYVT
YYYARKEGYSHLGLQPLPALQVSEYKAKQAIEMGLLLTSLSKSQYASELWGLTDTSAE
LLLTPPRNTFKKKGYTVNVWFDNNENNTFPYTNWEYIYYQDDIEQWHRTRGEVDYNGL
YFTENNGNRAYFLLFDSDAQTYSQTGTWTVHYKNQIISAPVTSSSKQSSDDYTSKAGQ
QPHFFASSSSPTTTDGGQTSQEGVSSSTTSPSAVRLRRRRSNEQQRELSSRESPRTKR
RRVPDEVDRQSAVGSAPTAEEVGSRHRSLPRSGISRLARLQGEARDPPILLIKGLANS
LKCWRYRLKKYTRYFKCMSTVFRWVDIDVPESSRHKLLVVFNDTTQRDVFMKLVTLPR
GCTYTFGTLNSL"
misc_feature 2587..3168
/gene="E2"
/note="E2 (early) protein, N terminal; Region: PPV_E2_N;
pfam00508"
/db_xref="CDD:278909"
misc_feature <3178..>3543
/gene="E2"
/note="transcriptional regulator ICP4; Provisional;
Region: PHA03307"
/db_xref="CDD:223039"
misc_feature 3541..3774
/gene="E2"
/note="E2 (early) protein, C terminal; Region: PPV_E2_C;
pfam00511"
/db_xref="CDD:395411"
gene 2930..3553
/gene="E4"
/db_xref="GeneID:1403642"
CDS <2930..3553
/gene="E4"
/codon_start=1
/product="hypothetical protein"
/protein_id="NP_043441.1"
/db_xref="GeneID:1403642"
/translation="MCGLIIMKIIHFPIQIGNIFTIRMILNNGTGPEERWTIMDFISQ
KIMEIEHIFSYLIVMHKHIHKLGHGQCIIKTKLFLLLLPAPQNNPPTTTLPKPGSNPT
SSPHPHRRLLPTEDRPHKRESLALPRRRVLFDYDAEDPTSNKENYPPESRPVPKDAEY
PTKSTDRVPWGLPQLLKRWEADIDLFLEAVYQDLQDFKEKLGILQSC"
misc_feature 3074..3544
/gene="E4"
/note="E4 protein; Provisional; Region: PHA03419"
/db_xref="CDD:223079"
gene 3807..5384
/gene="L2"
/db_xref="GeneID:1403643"
CDS 3807..5384
/gene="L2"
/note="putative"
/codon_start=1
/product="minor capsid protein L2"
/protein_id="NP_043442.1"
/db_xref="GeneID:1403643"
/translation="MYARVKRVKRDSVENLYKQCQLGADCPPDVRNKVEGTTLADRLL
QIFGSILYLGNLGIGTGKGSGGATGYTPLGTARVPASTPGTVIKPTRPFSVPLDPIGS
GIPSQPVGGRLPVDIIDASASSIIPLQEVLPETTIIVGGDSGPGLGASEIDIVSEPRP
DVVGVDTQPTVYTSIDNTVATLDITPATPPVKKIILDPISSGSEGAAAITFSDISAAD
LNVFVDPQGAGDRISFGEEIELGPINQPAQFEIEEPPRTSTPGEGFQRVTTRARELYN
RFVQQQPTQNIDFLGRPSRAVQFEFENPAFFNDEVTMQFEQDLQEVAAAPDQDFADVR
ELGRARFSETSAGTIRVSRLGTKGTMKTRSGLTIGQKVHFYFDISDIPAAETIQLRTL
GESSHDFSAVDNITESTYINLTETTNEGLIPDNILEDEFTENFNNAQLIFATIDEGES
MIMPTIPPGVALKLFIPEIAASVLNVVHPSSEWTILIPNVPDEIIQPAMAVDVYDDFY
LHPHLLRRRKRKRLDFF"
misc_feature 3822..5339
/gene="L2"
/note="Late Protein L2; Region: Late_protein_L2; cl28153"
/db_xref="CDD:332973"
gene 5395..6921
/gene="L1"
/db_xref="GeneID:1403644"
CDS 5395..6921
/gene="L1"
/note="putative"
/codon_start=1
/product="major capsid protein L1"
/protein_id="NP_043443.1"
/db_xref="GeneID:1403644"
/translation="MALWLQTAGQLYLPPSKPVARVLSTDEYVQPTNLVFHTGTDRML
IVGHPYFDIIDSGSNNITVPKCSGNQFRVMRLLFPDPNKFAMIDRAVFNPERERLVWR
LEGLEIGRGGPLGIGTSGHPLFNKYGDTENPAAYPLKQNNGDDNRMDVSMDPKQMQLF
IVGCKPATGEHWDIAKPCDPAPAKGSCPPIKLTQSIIQDGEMCDTGFGNANFITLQED
KSGVPLDITNEICKYPDLLKMTKDIYGDAVFFFGKREQIYSRHYFVRGGIDGDSLPDS
GYYLAPQTDKPQNNLGGYSYFPTPSGSVASSDNQLFNRPYWLHRAQGANNGICWGNQL
FITIVDNTRNTNLSISVYKQDAAIDNRYKYKQEDFRQYLRHTEEYEVELILRLCKVPL
NPDVLAHLNVMDKNILEDWQLSFVPPPPQGIEDAYRYIMSQATMCPTDVPNTEREDPY
KQYTFWTIDLQERFSNELSQFSLGKRYLYQYGLLNGRKRSASSFVTKKSKTVKRKRTK
"
misc_feature 5395..6918
/gene="L1"
/note="major capsid L1 protein; Provisional; Region:
PHA02778"
/db_xref="CDD:222928"
ORIGIN
1 tataggatat acactgattg ttggcaacta tcattaaatc ataaaaaaaa tatgaccaga
61 agaggtatat ataaatagct gagacgttcg taaactttag gatgcagatg gaagaagaca
121 ggtttccaac aacagtggct gattattgct ctgaatttga tattccttta aaagatctta
181 agttaaaatg tgtattttgt agattttact taactgaaca gcagttggct gcattttata
241 ttaagaattt aaagttagtt tggaaaaacc gttattgctt tgcttgttgt actccgtgtc
301 ttagacttac tgctaaattt gaagctgaaa actattttca gtgtatgtgt aaaggagaag
361 tattagaagt tctaactcgt attcctttga gttctctttc tgtacgctgt tttgattgcc
421 ttacattgtt atcttttgca gaaaaaatag attgtataat tagtggtcaa aacttttatc
481 ttgtaagggg tcgctggaga tcatattgta gaaattgcat tgagaaatga ttggtaatca
541 gcctaatgtt aataaccttg atgtaaattt ggaggagttg gttttacctg tcagtctttt
601 agctgatgag gagttgtcac ccgatggtga tcctgaggag gaggagcact atccctatac
661 aatagacacc tgttgcaaac cttgtggagc aggtgttaga tttactatta ttgctactcc
721 ttctgctgta ataactcttc gtcaactatt gcttcaagaa gtgttcctga cctgtttgag
781 gtgctccaga tccctttttc gacatggcag atcctaataa aggtattaat tctcttgaat
841 taaatgaggg gcatagcgaa tggtatgttg tgacagaagc tgagtgtatt aatagtttgg
901 atacaatgga agagctattt gaagaaagta cagatggatc tattgtgtcc aatctgatag
961 acgattccga ggaactggag gagggaaatt ccctggcact ctacaatgaa cagttaacag
1021 aggattgcaa tagagctatt ttagcgctaa aacgaaagtt aactaaaaca cctttgaaaa
1081 gccaggacag aacggttgct gacctaagtc caaggttgga agctgtcaca atttcacctc
1141 agagacaaag caaaaggaga ttatttgagg acagtggatt aggagaagat gaagctacaa
1201 attctattga aaaaaaggta gtttcgaact ctttagagag taatgaaagt gggaccttgg
1261 ttgtggaaac ggacagtata tttcgcagta ctaatagaaa agccacttta ttggctaaat
1321 ttaaagaata ctttggtgta gcatatggag atttaacgcg accgtttaaa agtgatagat
1381 catgttgtga aaactgggtt ataagtgtgt gtgccgctgc agaagaagta atagaagctt
1441 caaaaacagt tatgcagcaa cattgtgatt ttttacaggt tatttcatat gggttttatg
1501 ctttatattt ggtaaaattt aaaacagcaa aaagtagaga tactataatg aaattatttt
1561 ctttaacatt gaatgtacaa gaacaacaat taatgtgtga tccaccaaaa tctagaagta
1621 ccccaacagc tctttatttt tatagaaggt catttggaaa tgcatcgttt atttatggac
1681 cgtttccaga ttggttagca aaattaacta tgttagacca tgaatccgcc gcgagctcag
1741 aacagtttga acttgctcaa atgattcaat ttgcttatga caataacttg acaactgaat
1801 ctgaaatagc ttataaatat gcattgttag ctgattctga tgctaatgca gctgcatttt
1861 taaaaagtaa tcaacaggta aaatatgtac gagactgcta tgcaatgtta agatattata
1921 aaagacaaga aatgaaagat atgtcaattt ctgagtggat atggaaatgt tgcgatgatt
1981 gtaatcaaga gggcaactgg aaattaatag cacaattttt acgttatcaa gaagttaatt
2041 tcatttcatt tttatgtgca ttaaagacat tgtttaaagg tattccaaaa agaaattgtt
2101 tagtgttttg gggacctcca gatacaggaa agtcttatat ttgttcttca cttacacggt
2161 ttatgcaggg aaaagtggta tctttcatga atagacacag tcaattttgg ctacaacctt
2221 tacaagattg taagcttgga ttcttagatg atgctacatt tcaatgttgg caatacatgg
2281 atgtaaatat gcgaaatgca ttagatggta atcatatttc attagattta aaacataaag
2341 ctcctttaca aataaaatta cctcctttat taataactac caatgttgat gttgaaaatg
2401 aagctagctt aatgtattta aagagtagac tagtattttt taagtttcct aacaaattac
2461 ctttaaaaga aaatgatgaa gtactttatg aaattactga tgcatcatgg aaatgttttt
2521 ttatcaaatt tgcaagccat ttagagctga cagccagagg agacgagcag catgaatcag
2581 gccgatctga ccgagcgttc cgatgcactg caggaacaaa tactgaatct atatgagcaa
2641 gattcaaagg acattcaggc ccaaatacaa tattgggatt taaatagaaa actatatgtc
2701 acatactatt atgcaagaaa agaaggctat tcgcatttgg gtcttcaacc cttaccagct
2761 ttgcaagtat cagagtacaa agccaagcag gcaatcgaaa tgggattgtt attaaccagt
2821 ttaagcaaat cccaatatgc ttcagaacta tggggtttaa cagatacaag tgcagaattg
2881 ttattaaccc ctccaagaaa tacatttaaa aagaagggat atactgtaaa tgtgtggttt
2941 gataataatg aaaataatac atttccctat acaaattggg aatatattta ctatcaggat
3001 gatattgaac aatggcacag gaccagagga gaggtggact ataatggact ttatttcaca
3061 gaaaataatg gaaatagagc atattttctc ctatttgata gtgatgcaca aacatattca
3121 caaactggga catggacagt gcattataaa aaccaaatta tttctgctcc tgttaccagc
3181 tcctcaaaac aatcctccga cgactacact tccaaagccg ggcagcaacc ccacttcttc
3241 gcctcatcct catcgccgac tactaccgac ggaggacaga cctcacaaga gggagtctct
3301 agctctacca cgtcgccgag tgctgttcga ttacgacgcc gaagatccaa cgagcaacaa
3361 agagaactat cctccagaga gtcgccccgt accaaaagac gcagagtacc cgacgaagtc
3421 gaccgacaga gtgccgtggg gtctgcccca actgctgaag aggtgggaag cagacataga
3481 tctcttccta gaagcggtat atcaagactt gcaagacttc aaggagaagc tcgggatcct
3541 ccaatcctgc taattaaagg tctagcaaac tcccttaaat gttggagata tcgattgaaa
3601 aagtatacac gttattttaa atgtatgagt acagtattta gatgggtaga catagacgta
3661 ccagaatctt ctagacataa attgttagtt gtttttaatg ataccacaca acgagatgtt
3721 tttatgaaat tagtaacttt gccaagaggt tgtacatata catttggaac attaaactct
3781 ttgtaatatt tgtaaaacaa aacaaaatgt atgctagagt aaagcgtgtt aaaagagact
3841 ctgttgaaaa cttatataaa caatgtcaac ttggtgctga ctgccctcct gatgtacgaa
3901 ataaagtaga aggaaccaca cttgcagatc gattattaca aatatttgga agtatcttat
3961 acctggggaa tttgggtata gggacaggta aaggatcggg gggtgctaca ggctatacac
4021 ctcttggtac tgcaagagtg ccagcgtcta cacctggaac agttataaaa cccacacgac
4081 cgttttcggt tcctttagat ccaataggtt ctggaattcc atcgcaacct gtaggaggtc
4141 ggttacctgt ggacattata gatgccagtg cttcctctat tatacccttg caggaggtcc
4201 tgccagagac caccattata gtaggcggtg acagcggtcc tggattgggt gcaagtgaaa
4261 ttgatatagt ttcagaacca agaccagatg tggtcggtgt tgatactcaa ccaacagtat
4321 atacctccat tgataataca gttgctacat tagacattac accagctaca ccaccagtga
4381 agaaaataat attagaccct ataagttcag gttctgaagg tgctgcagca ataacatttt
4441 cagatataag tgctgcagat ttaaatgtat ttgttgatcc tcagggagca ggagatagaa
4501 taagttttgg agaagaaata gagttaggcc ctattaatca gcctgctcaa tttgaaatag
4561 aagaacctcc acgtaccagt acacctgggg agggatttca acgtgttaca acacgggcaa
4621 gggaattata taatagattt gtgcagcaac agccaacaca aaatattgac ttcttaggac
4681 gtccttcccg cgctgtacaa tttgaatttg aaaatcccgc cttttttaat gatgaggtga
4741 ctatgcagtt tgagcaagat ttgcaagagg tggctgcagc gccagaccag gattttgcag
4801 atgtcaggga attaggacga gctcggtttt cagaaacatc tgcaggaaca atacgagtca
4861 gcagattagg aacaaaagga acaatgaaaa cacgaagtgg actaactatt ggtcagaaag
4921 ttcactttta ttttgatatt agtgatattc cagctgcaga aaccatacaa ctaagaacat
4981 taggcgagtc ttcccacgat ttttctgcag tagataatat tactgaaagt acatatatta
5041 atttaactga aactacaaat gaaggcctaa tacctgacaa tatactagag gatgaattta
5101 cagaaaactt taataatgca cagctgatat ttgcaacaat agatgaagga gaatctatga
5161 tcatgcccac aattcctcca ggtgtagctt taaagttatt tattccagaa atagctgcaa
5221 gcgtgttaaa tgtggttcat ccttcttctg agtggactat tttgattcct aatgttccag
5281 atgaaattat tcagcctgct atggcagtag atgtttatga tgacttttat ttacatcctc
5341 atcttcttag gcgacgcaaa cgaaaacggt tggatttttt ttaatgtttt acagatggct
5401 ctttggttgc agacagctgg acaattgtat cttccaccaa gcaagcctgt tgctcgtgta
5461 ctcagtacgg atgaatatgt acagccaaca aatttagttt ttcatacagg aactgacaga
5521 atgctaattg taggacaccc ttattttgat attatagaca gtggttcaaa taatattact
5581 gtacctaaat gtagtggaaa tcagtttaga gttatgcgac tactatttcc agatccaaac
5641 aaatttgcaa tgatagacag agctgtcttt aacccagaaa gagagagatt agtctggaga
5701 ttggaaggcc ttgaaattgg tagaggtggg cctttaggaa ttggaacttc tggccatcca
5761 ttatttaata aatatggaga tacagaaaat cctgccgcat atcctttaaa gcagaataat
5821 ggtgatgaca atagaatgga tgtttcaatg gatccaaaac aaatgcaatt gtttattgta
5881 ggatgtaaac cagccactgg tgaacactgg gatattgcta aaccttgtga tcctgctcca
5941 gcaaaaggat cctgtccccc aattaaatta acacagtcta taattcagga cggtgaaatg
6001 tgcgatacag gctttggaaa tgcaaatttt attaccttgc aagaagataa atcaggtgtt
6061 cctctagata ttaccaatga aatttgtaaa tatcctgatt tactaaaaat gacaaaagat
6121 atctatggag atgcagtatt tttctttggt aaacgtgaac aaatttattc caggcattat
6181 tttgtaagag gagggataga tggagatagt ttgccagatt ctggatatta cttagcacca
6241 caaactgata aacctcaaaa taaccttggt ggttatagtt acttccctac accaagtggt
6301 tctgtagctt ctagtgataa tcaacttttt aatagacctt attggcttca cagagcccaa
6361 ggtgcaaata atggtatttg ttggggtaac caattattca ttactatagt agataatact
6421 cgaaatacta atttatctat ttcagtttac aaacaagatg ctgctattga taacagatat
6481 aaatataaac aggaagattt tagacagtat ttacgccata ctgaagaata tgaagtagag
6541 ttaattctga gactctgtaa agtgcctttg aatccagatg ttctagctca tttaaatgta
6601 atggacaaaa atattttaga ggattggcaa ctttcatttg tacctccacc accacaaggt
6661 attgaagatg cttacagata tataatgtct caggcaacaa tgtgtccaac agatgttcct
6721 aatactgaaa gggaagaccc ttataaacag tatacatttt ggacaataga tttgcaagaa
6781 cgtttttcta acgaattatc ccagttttct cttggaaaaa gatatttata tcagtatggc
6841 ttacttaacg gacgaaaacg gtctgctagt agttttgtaa cgaagaaatc aaaaactgtg
6901 aaacgtaaaa gaactaaata aatacatata tatattatat gattaatgaa ggatatatta
6961 attaataatg ctgctgttgt aaaatgaagg attaataaat tgcacatcag caagtgtctg
7021 actcacgggg tctacatttt tgtctaccgc gccttcataa ttatcttggc attgcatatc
7081 gagactataa gaaacaatca cttggcacac tctcggattt aacaagcatt gctggacact
7141 taccaaccgt aactggttaa aaaagagcgc caaaggggaa acaggcaacc gttttcgttc
7201 tcctgaagga acgttttcca ggtaagtaca tgttcataca aagttttgac tcactctctt
7261 tgttagaaac catttccgtt ctgtggatat gcgccagacc aaaaacggtt gcc
//
