LOCUS NC_006296 15882 bp RNA linear VRL 13-AUG-2018
DEFINITION Rinderpest virus (strain Kabete O), complete genome.
ACCESSION NC_006296
VERSION NC_006296.2
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq; C protein; complete genome; F protein; H protein; L
protein; M protein; N protein; P protein.
SOURCE Rinderpest virus (strain Kabete O)
ORGANISM Rinderpest virus (strain Kabete O)
Viruses; Riboviria; Orthornavirae; Negarnaviricota;
Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae;
Orthoparamyxovirinae; Morbillivirus; Morbillivirus pecoris.
REFERENCE 1
AUTHORS Baron,M.D., Kamata,Y., Barras,V., Goatley,L. and Barrett,T.
TITLE The genome sequence of the virulent Kabete 'O' strain of rinderpest
virus: comparison with the derived vaccine
JOURNAL J. Gen. Virol. 77 (PT 12), 3041-3046 (1996)
PUBMED 9000095
REFERENCE 2 (bases 1 to 15882)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (08-DEC-2004) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 15882)
AUTHORS Baron,M.D.
TITLE Direct Submission
JOURNAL Submitted (07-DEC-2004) M.D. Baron, Institute for Animal Health,
Ash Road, Pirbright, Surrey GU24 0NF, UK
REFERENCE 4
AUTHORS Baron,M.D.
TITLE Direct Submission
JOURNAL Submitted (17-SEP-2004) M.D. Baron, Institute for Animal Health,
Ash Road, Pirbright, Surrey GU24 0NF, UK
REMARK revised by [4]
REFERENCE 5
AUTHORS Baron,M.D.
TITLE Direct Submission
JOURNAL Submitted (04-JUN-1996) M.D. Baron, Institute for Animal Health,
Ash Road, Pirbright, Surrey GU24 0NF, UK
REMARK revised by [3]
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to X98291.
On Dec 8, 2004 this sequence version replaced NC_006296.1.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..15882
/organism="Rinderpest virus (strain Kabete O)"
/mol_type="genomic RNA"
/strain="Kabete 'O' virulent"
/isolation_source="infected animal"
/host="cattle, wild bovids, other artiodactyls"
/db_xref="taxon:11242"
/country="Kenya"
regulatory complement(1..100)
/regulatory_class="promoter"
/note="genome promoter"
gene 108..1685
/locus_tag="RPVgp1"
/db_xref="GeneID:3021777"
CDS 108..1685
/locus_tag="RPVgp1"
/codon_start=1
/product="N protein"
/protein_id="YP_087120.2"
/db_xref="GOA:Q629I6"
/db_xref="InterPro:IPR002021"
/db_xref="UniProtKB/TrEMBL:Q629I6"
/db_xref="GeneID:3021777"
/translation="MASLLKSLALFKRAKDKPPLAAGSGGAIRGIKHVIVVPIPGDSS
ITTRSRLLDRLVKMVGDPDISGPKLTGALISILSLFVESPGQLIQRITDDPDISIKLV
EVVQSDKTQSGLTFASRGTSMDDEADRYFTYEEPNDGEERQSYWFENRDIQDIEIQDP
EGFNMILATILAQIWILLAKAVTAPDTAADSELRRWVKYTQQRRVIGEFRLDKGWLDT
VRNRVAEDLSLRRFMVALILDIKRTPGNKPRIAEMICDIDTYIVEAGLASFILTIKFG
IETMYPALGLHEFAGELSTIESLMNLYQQMGELAPYMVILENSIQNKFSAGAYPLLWS
YAMGIGVELENSMGGLNFGRSYFDPAYFRLGQEMVRRSAGKVSSNLASELGITEEEAR
LVSEIAAYTSDDRNNRTSGPKQAQVSFLRTDQGSEAQHSASKKDEARAPQVKKETRTS
SKSDKHKEGTDKEPVSSSAMTLIDVDTTLEADTDPLESKKSAEALLRLQAMAGILGDS
TLGNDSLRAYNDKDLLN"
misc_feature 108..1679
/locus_tag="RPVgp1"
/note="Paramyxovirus nucleocapsid protein; Region:
Paramyxo_ncap; pfam00973"
/db_xref="CDD:395775"
gene 1807..3330
/locus_tag="RPVgp2"
/db_xref="GeneID:3021775"
CDS 1807..3330
/locus_tag="RPVgp2"
/codon_start=1
/product="P protein"
/protein_id="YP_087121.2"
/db_xref="GOA:Q629I5"
/db_xref="InterPro:IPR004897"
/db_xref="InterPro:IPR016075"
/db_xref="UniProtKB/TrEMBL:Q629I5"
/db_xref="GeneID:3021775"
/translation="MAEEQAYHVNKGLECIKALRARPLDPLVVEEALAAWVETSEGQT
LDRMSSDEAEADHQDISKPCFPAAGPGKSSMSRCHDQGLGGSNSCDEELGAFIGDSSM
HSTEVQHYHVYDHSGEKVEGVEDADSILVQSGADDGVEVWGGDEESENSDVDSGEPDP
EGSAPADWGSSPISPATRASDVETVEGDEIQKLLEDQSRIRKMTKAGKTLVVPPIPSQ
ERPTASEKPIKKGTDVKSTSSGTMAESSSTGGATRPALKSQWGPSGPNASAENALASA
SNVSPTQGSKTESGTTTSRISQSNIEPEDDYDDELFSDIQDIKTALAKLHDDQQIIIT
RLESLLSLKGEIDSIKKQISKQNISISTIEGHLSSVMIAIPGFGKDPNDPTADVDINP
DLRPIIGRDSGRALAEVLKKPASERQSKDTGKLGIESKGLLKKEFQLKPIEKKSSSAI
RFVPDGSVASRSVIRSIIKSSHLGEDRKDYLMSLLNDIQGSKDLAQFHQMLVKILKN"
misc_feature 1816..2742
/locus_tag="RPVgp2"
/note="Paramyxovirus structural protein V/P N-terminus;
Region: Paramyxo_PNT; pfam13825"
/db_xref="CDD:372740"
misc_feature 2776..3312
/locus_tag="RPVgp2"
/note="C-terminal domain of Measles virus phosphoprotein
and related proteins; Region: MEV_P-protein-C_like;
cl03936"
/db_xref="CDD:413868"
gene 1829..2362
/locus_tag="RPVgp3"
/db_xref="GeneID:3021779"
CDS 1829..2362
/locus_tag="RPVgp3"
/codon_start=1
/product="C protein"
/protein_id="YP_087122.1"
/db_xref="InterPro:IPR003875"
/db_xref="UniProtKB/TrEMBL:Q629I4"
/db_xref="GeneID:3021779"
/translation="MSTKAWNASRLSGPDPSTPWSLKKPLQHGSRPPKGKRLTVCPPT
RPKQTIRISASHASQQLDQAKAACLAVTIRDLEEATAVMRSWEHSLVTPQCIAPRYSI
IMFMITAVKRLRESKMLTLSWFNQALMMVSKSGEEMRNLRTAMWILANLIPREVLPLT
GDLLPSLQQQEPPMLKQ"
misc_feature 1859..2329
/locus_tag="RPVgp3"
/note="Non-structural protein C; Region: Paramyxo_NS_C;
pfam02725"
/db_xref="CDD:280822"
gene 3438..4445
/locus_tag="RPVgp4"
/db_xref="GeneID:3021778"
CDS 3438..4445
/locus_tag="RPVgp4"
/codon_start=1
/product="M protein"
/protein_id="YP_087123.1"
/db_xref="GOA:Q629I3"
/db_xref="InterPro:IPR000982"
/db_xref="UniProtKB/TrEMBL:Q629I3"
/db_xref="GeneID:3021778"
/translation="MAEIYDFDKSAWDVKGSIAPIRPKTYSDGRLIPQVRVIDPGLGD
RKDECFMYIFLLGIVEDSDPLSPPRGRTFGSLPLGVGKSTAKPEELLKEVTDLDIVVR
RTAGLNEKLVFYNNTPLSLLTPWKKILTTGSVFNANQVCNAVNLIPLDTPQRFRVVYM
SITRLSDSGYYTVPRKILEFRSANAVAFNLLVTLEIDRDTEPGRPAAGGLGLSEATFM
VHVGNFRRKKNEAYSADYCKMKIEKMGLVFALGGIGGTSLHIRSTGKMSKTLHAQLGF
KKTLCYPLMDINEDLNRLLWRSRCKIVRIQAVLQPSVPQEFRIYDDVIINDDQGLFKV
L"
misc_feature 3447..4430
/locus_tag="RPVgp4"
/note="Viral matrix protein; Region: Matrix; pfam00661"
/db_xref="CDD:395535"
gene 5458..7098
/locus_tag="RPVgp5"
/db_xref="GeneID:3021776"
CDS 5458..7098
/locus_tag="RPVgp5"
/codon_start=1
/product="F protein"
/protein_id="YP_087124.2"
/db_xref="GOA:Q629I2"
/db_xref="InterPro:IPR000776"
/db_xref="UniProtKB/TrEMBL:Q629I2"
/db_xref="GeneID:3021776"
/translation="MKILFATLLVVTTPHLVTGQIHWGNLSKIGVVGTGSASYKVMTQ
SSHQTLVIKLMPNITAIDNCTKTEIEEYKRLLGTVLQPIKVALNAITKNIKPIRSSTT
SRRHRRFAGVALAGAALGVATAAQITAGIALHQSMMNTQAIESLKASLETTNQAIEEI
RQAGQEMILAVQGVQDYINNELVPAMGQLSCDIVGQKLGLKLLRYYTEILSLFGPSLR
DPISAEISIQALSYALGGDINKILEKLGYSGSDLLAILESKGIKAKITYVDIESYFIV
LSIAYPSLSEIKGVIIHRLEGVSYNIGSQEWYTTVPRYVATQGYLISNFDDTPCAFSP
EGTICSQNALYPMSPLLQECFRGSTRSCARTLVSGSIGNRFILSKGNLIANCASILCK
CYTTGSIISQDPDKILTYIAADQCPIVEVDGVTIQVGSREYPDAVYLHKIDLGPPISL
EKLDVGTNLGNAVTKLEKAKDLLDSSDLILETIKGASVTNTGHILVGAGLIAVVGILI
VTCCCRKRSNDSKVSTVILNPGLKPDLTGTSKSYVRSL"
misc_feature 5521..6906
/locus_tag="RPVgp5"
/note="Fusion glycoprotein F0; Region: Fusion_gly;
pfam00523"
/db_xref="CDD:395418"
gene 7259..9088
/locus_tag="RPVgp6"
/db_xref="GeneID:3021774"
CDS 7259..9088
/locus_tag="RPVgp6"
/codon_start=1
/product="H protein"
/protein_id="YP_087125.2"
/db_xref="GOA:Q629I1"
/db_xref="InterPro:IPR000665"
/db_xref="InterPro:IPR011040"
/db_xref="UniProtKB/TrEMBL:Q629I1"
/db_xref="GeneID:3021774"
/translation="MSPPRDRVDAYYKDNFQFKNTRVVLNKEQLLIERPCMLLTVLFV
MFLSLVGLLAIAGIRLHRAAVNTAKINNDLTTSIDITKSIEYQVKDVLTPLFKIIGDE
VGLRTPQRFTDLTKFISDKIKFLNPDKEYDFRDINWCINPPERIKIDYDQYCAHTAAE
DLITMLVNSSLTGTTVLRTSLVNLGRNCTGPTTTKGQFSNISLTLSGIYSGRGYNISS
MITITGKGMYGSTYLVGKYNQRARRPSIVWQQDYRVFEVGIIRELGVGTPVFHMTNYL
ELPRQPELETCMLALGESKLAALCLADSPVALHYGRVGDDNKIRFVKLGVWASPADRD
TLATLSAIDPTLDGLYITTHRGIIAAGTAIWAVPVTRTDDQVKMGKCRLEACRDRPPP
FCNSTDWEPLEAGRIPAYGVLTIKLGLADEPKVDIISEFGPLITHDSGMDLYTSFDGT
KYWLTTPPLQNSALGTVNTLVLEPSLKISPNILTLPIRSGGGDCYTPTYLSDRADDDV
KLSSNLVILPSRDLQYVSATYDISRVEHAIVYHIYSTGRLSSYYYPFKLPIKGDPVSL
QIECFPWDRKLWCHHFCSVIDSGTGEQVTHIGVVGIEITCNGK"
misc_feature 7817..9061
/locus_tag="RPVgp6"
/note="Measles virus hemagglutinin; Region: MV-h; cd15467"
/db_xref="CDD:271231"
misc_feature order(7829..7846,8648..8653,8705..8707,8756..8758,
8765..8767,8771..8773,8879..8881,8885..8887,8897..8899,
8906..8908)
/locus_tag="RPVgp6"
/note="receptor binding site [polypeptide binding]; other
site"
/db_xref="CDD:271231"
misc_feature order(7859..7861,7865..7873,7880..7885,7892..7894,
7898..7900,7964..7966,7973..7975,8039..8041,8045..8053,
8069..8074,8081..8083,8087..8089)
/locus_tag="RPVgp6"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:271231"
misc_feature 7904..8098
/locus_tag="RPVgp6"
/note="Sialidase propeller 1 [structural motif]; Region:
Sialidase propeller 1"
/db_xref="CDD:271231"
misc_feature 8105..8263
/locus_tag="RPVgp6"
/note="Sialidase propeller 2 [structural motif]; Region:
Sialidase propeller 2"
/db_xref="CDD:271231"
misc_feature 8294..8563
/locus_tag="RPVgp6"
/note="Sialidase propeller 3 [structural motif]; Region:
Sialidase propeller 3"
/db_xref="CDD:271231"
misc_feature 8567..8710
/locus_tag="RPVgp6"
/note="Sialidase propeller 4 [structural motif]; Region:
Sialidase propeller 4"
/db_xref="CDD:271231"
misc_feature 8783..8917
/locus_tag="RPVgp6"
/note="Sialidase propeller 5 [structural motif]; Region:
Sialidase propeller 5"
/db_xref="CDD:271231"
misc_feature 8945..9061
/locus_tag="RPVgp6"
/note="Sialidase propeller 6 [structural motif]; Region:
Sialidase propeller 6"
/db_xref="CDD:271231"
gene 9222..15773
/locus_tag="RPVgp7"
/db_xref="GeneID:3021780"
CDS 9222..15773
/locus_tag="RPVgp7"
/function="polymerase"
/codon_start=1
/product="L protein"
/protein_id="YP_087126.2"
/db_xref="GOA:Q86499"
/db_xref="InterPro:IPR001016"
/db_xref="InterPro:IPR014023"
/db_xref="InterPro:IPR016269"
/db_xref="UniProtKB/TrEMBL:Q86499"
/db_xref="GeneID:3021780"
/translation="MDSLSVNQILYPEVHLDSPIVTNKLVAILEYARIPHKYVLEDPT
LCKNIKHRLDSGFSNQMIINNVEIGNVVQSKLKGYPNHEHIPYPECNQELFNARDKKA
TEKIRSLFKKGTTLYTKISDKVCTCLETANSRLGLGADLGIGIKEKILSLSLYMQSSQ
WYEPFLFWFTIKTEMRSTIKSSVHTSHRRRYVPSFFSGDSFEILISRDLVAIVHRRLH
HVYYLTFELVLMYCDIIEGRLMTETAMVIDPRYTELLERVRYMWKLIDGFFPTLGNST
YQVVALLEPLSLAYLQLRDVTTELRGAFLNHCFTEIREILNQNGVTDDNTYHEIVEAL
DYIFITDDIHLTGEIFSFFRSFGHPRLEAITAADNVRKHMNQPKVIVYETLMKGHAIF
CGIIINGYRDRHGGSWPPIHLPVHAATSIRNAQASGEGLTYEQCVDNWKSFAGVRFGC
FMPLSLDSDLTMYLKDKALAALKKEWDSAYPKEFLRYNPPKSTSSRRLVDVFLNDSTF
DPYNMIMYVVSGDYLRDPDFNSSYSLKEKEIKETGRLFAKMTYKMRACQVIAENLIPN
GIGKYFRDNGMAKDEHDLTKALHTLAVSGVPKDFKDNYRGGPRAKTFSSKKTHTGAGI
SRVSRNEANYRSPEQRGCNTGGPDQIESYETVSAFITADLKKYCLNWRYETISLFAQR
LNEIYGLPSFFQWLHRRLERSVLYVSDPHCPPDLDSHVNLDNVPNDQIFIKYPMGGIE
GYCQKLWTISTIPYLYLAAHESGVRIASLVQGDNQTIAVTKRVPSSWPYHLKKREAAR
VTREYFCLLRQRLHDIGHHLKANETIVSSHFFVYSKGIYYDGLLISQSLKSIARCVFW
SETIVDETRAACSNIATTIAKSIERGFDRYLAYSLNILKVIQQILISLGFTINSTMTQ
DVVVPLLSNHDLLIRMALLPAPIGGMNYLNMSRLFVRNIGDPVTSSIADLKRMIGASL
MPEETLHQVMTQQPGDSSFLDWASDPYSANLVCIQSITRLLKNITAKYVLINSPNPML
RGLFHDDSKEEDEQLATFLMDRSVIVPRAAHEILDHSITGAREAIAGMLDTTKGLIRT
SSRRGGLTTRVIARLSTYDYEQFRSGMVLLTGSKRNYLIDRDSCSVQLARALRSHMWA
RLARGRPIYGLEVPDVLESMRGHLIQRHATCILCDFGSANYGWFFVPSNCQLDDIDRE
TSALRVPYIGSTTDERTDMKLAFVKSPSRTLRSAVRIATVYSWAYGDDDKSWNEALKL
AQQRAKVSLEELKMITPISTSTNLAHRLRDRSTQVKYSGTSLVRVARYTTISNDNLSF
VISDKKVDTNFIYQQGMLLGLGVLETLFRLDKDTGPSNTVLHLHVETDCCVIPMVDHP
RIPSLHELKFRRELCTNPLIYDSAPIIDREATKLYTQSHRRHLVEFVTWSTSQLYHIL
AKSTALSMIDLVTKFEKDHMNEVSALIGDDDINSFITEFLLVEPRLFTVYLGQCTAIN
WAFDIHYHRPSGKYQMGELLTSFLARMSKSVFKVFVNALSHPKIYRKFWHSGIIEPIH
GPSLDTQNLHITVCNMIYSCYMTYLDLLLNDELDEFTYLLCESDEDIVADRFDNIQAR
HLCVLSDLYCNPRGCPTIRGLQPVEKCAIMTKHIEAEAKLSLAGPSWNIGPIVIDHFS
CSLTYLRRGSIKQIRLRVDPGFIFEALTVTDPQKPNFQHEQAADMHISNFRPPYDGVA
ELLGTINSSKHNLPILGTGVYNYEVHAFRRIGLNSSACYKAVEISTLIKSSMDPEEDS
LFLGEGSGSMLITYKEILKLKKCFYNSGVSAESRSGQRELAPYPSEVSLVEHQLGAEK
TVKVLFNGRPEVTWIGSVDCFNYIISNIQTSSLGLIHSDIETLPTKDITEKLEELSAI
LALALLLGKVGSVLVIKVMPISGDYVQGFMSYVVPYYREVLIIYPRYSNFISTEAYLV
LLGLRANRLIDPERIKQQVMESGIRTIPGLVGHILSIKQLNCIQSQAGPAITRGEINP
ILRKLTPIERILISCGLTINGTKICSDVVHHDISSGPDGLLNSSIILLKELARFRDNQ
RSQQGMFHAYPVLLSSRQRELISRVARKFWGYILLYSSDRRLLSRLVSNLKSGYLLFD
LHQNLFMKNLSKSEKQLIRTGGLKREWLFKLTTKEIKEWFKLIGYSALIRE"
misc_feature 9258..12575
/locus_tag="RPVgp7"
/note="Mononegavirales RNA dependent RNA polymerase;
Region: Mononeg_RNA_pol; pfam00946"
/db_xref="CDD:395756"
misc_feature 12924..15761
/locus_tag="RPVgp7"
/note="mRNA capping enzyme, paramyxovirus family; Region:
paramyx_RNAcap; TIGR04198"
/db_xref="CDD:275046"
regulatory 15782..15882
/regulatory_class="promoter"
/note="antigenome promoter"
ORIGIN
1 accaaacaaa gttgggtaag gatcggtcta tcaatgatta tgatttagca cacttaggat
61 tcaagatcct atcgactgga gcaggcttaa ggtaaaggtt ctttaaaatg gcttctctct
121 tgaagagctt agctctgttc aaaagggcca aagacaagcc accccttgct gcaggctctg
181 gtggggctat ccggggaatc aaacatgtca ttgttgttcc gattcctggg gattcctcaa
241 tcaccacaag atcccgcctc ctagaccgtc tcgttaaaat ggtgggagac ccagacatca
301 gtggccctaa attaaccggg gctctcatca gcatcttatc actgtttgtc gagtcaccag
361 gccaacttat tcagagaatc actgatgacc ctgatatcag cattaaattg gtggaggtag
421 tccaaagtga caaaactcaa tcagggctga catttgcctc taggggtacg agcatggatg
481 acgaggctga tagatatttc acttatgaag aacccaatga cggagaagaa aggcagtctt
541 actggtttga gaatcgagat attcaagaca ttgagatcca ggatccagaa gggttcaata
601 tgatactggc aaccatctta gcccagatct ggatcttact agctaaagca gtcacagccc
661 ctgatactgc agccgattca gagttacgga ggtgggtgaa atacactcaa caaaggaggg
721 taattggaga attcagactt gacaaaggat ggcttgacac agtgcgcaac agggtagcag
781 aagatctctc tttacgcaga tttatggtgg cattgatctt agatatcaag agaaccccag
841 gcaataaacc aaggatcgct gaaatgatct gtgacattga tacctacata gtggaggcag
901 ggttggccag ttttatactc actatcaaat ttggtataga aacgatgtac ccagcactgg
961 gcctgcatga attcgccgga gagctctcca caatcgagtc tcttatgaat ctgtaccagc
1021 aaatgggtga actggctcct tatatggtga tcttagagaa ctcaatccag aacaagttca
1081 gtgcaggagc ataccccctg ttgtggagct atgctatggg gattggggtt gaattagaga
1141 attctatggg gggacttaat tttggcaggt cgtactttga ccctgcatat ttcagattag
1201 gacaagaaat ggtaaggagg tcagctggga aggtcagctc caacctggca tctgagctcg
1261 gcatcaccga ggaggaagca agacttgtct ctgagatcgc agcatacaca agtgatgatc
1321 ggaacaatag aacctctgga cccaaacagg cccaggtttc attccttcgc accgatcaag
1381 ggagtgaggc ccagcacagc gcaagcaaga aagatgaagc tagagcaccc caggtcaaga
1441 aggaaaccag gaccagcagc aagtcagaca agcacaagga aggtacagac aaagaacctg
1501 taagctcctc agctatgact ctgattgatg tggacacaac cctcgaggca gatactgatc
1561 ctctagagag caagaagtca gcagaggctc ttcttagact gcaggctatg gccggcatct
1621 taggggactc aacccttggc aatgacagtc tgagagcata caacgacaag gatcttctca
1681 actgagtgag tgccccgcac gcttcagcac gcaatctccc catgcaaagc gccattataa
1741 aaaacttagg acccaggtct acaaatccgc tcaccccggg acaacccgcc ccagcgaccg
1801 acccagatgg cagaggagca agcttaccat gtcaacaaag gcctggaatg catcaaggct
1861 ctcagggccc gacccctcga ccccctggtc gttgaagaag cccttgcagc atgggtcgag
1921 acctccgaag ggcaaacgct tgaccgtatg tcctccgacg aggccgaagc agaccatcag
1981 gatatcagca agccatgctt cccagcagct ggaccaggca aaagcagcat gtctcgctgt
2041 cacgatcagg gacttggagg aagcaacagc tgtgatgagg agctgggagc attcattggt
2101 gactcctcaa tgcatagcac cgaggtacag cattatcatg tttatgatca cagcggtgaa
2161 aaggttgagg gagtcgaaga tgctgactct atcctggttc aatcaggcgc tgatgatggt
2221 gtcgaagtct ggggaggaga tgaggaatct gagaacagcg atgtggattc tggcgaacct
2281 gatcccgagg gaagtgctcc cgctgactgg ggatcttctc ccatctctcc agcaacaaga
2341 gcctccgatg ttgaaacagt agaaggggac gagatccaaa agctgctgga agatcagtca
2401 cggattcgga aaatgaccaa ggcagggaag actcttgtgg tgccgccgat cccctctcag
2461 gagaggccaa ctgcatcaga gaaacccatt aaaaagggca cagacgtgaa atcgacctca
2521 tctggaacga tggccgagtc ttcatcgaca ggtggtgcaa cccgacctgc tctaaagtca
2581 cagtggggac cgtcagggcc aaatgcatct gcggagaatg ccctcgcgtc tgcgagcaat
2641 gtatcaccga ctcagggatc gaaaacagaa tctggtacca caacctcgcg gatatcccag
2701 agtaacattg agcctgagga tgattacgat gatgagctgt tctcggatat ccaagacatc
2761 aaaacagctc tagctaaatt gcatgatgac cagcaaatta taattaccag gttagagtca
2821 ctgctttcgc tcaagggaga gattgattcg atcaagaagc aaatcagtaa gcagaacatt
2881 agcatctcta ccatagaagg ccatctctcc agcgtcatga tcgcaatccc gggatttggc
2941 aaggatccca acgatcccac tgccgatgtc gacatcaacc ctgatctgag acccataatt
3001 ggtcgggact ccgggagagc ccttgctgaa gtactcaaaa agccggcctc agaaaggcaa
3061 tccaaggaca ctggcaaatt agggatcgag tccaaaggcc tgttgaagaa agagttccaa
3121 ctgaaaccaa tagaaaagaa atctagttcg gctatcagat tcgtcccgga cggcagtgtt
3181 gcatctcgca gtgtgatccg ttcaatcatc aagtcaagtc atctcgggga ggatcgcaag
3241 gattacctga tgagtctctt gaatgacatt cagggctcca aggatcttgc tcagttccat
3301 cagatgctgg tcaaaattct aaagaactag actcggcaca acatagctga tctcctcgct
3361 tcccctcagc ttagctacag cttgcatgct cattataaaa aacttaggag caaagcataa
3421 cgcctcgcac tcccaacatg gcagaaattt atgattttga caaatcagcg tgggatgtca
3481 aagggtcgat tgcaccaatc aggccaaaaa catacagtga cggccgattg attccccaag
3541 tgagagtaat tgatccagga ctcggggatc ggaaagacga gtgctttatg tatatcttcc
3601 ttctggggat tgtagaagac agtgacccgc taagtccccc gcgaggccga acttttggtt
3661 ccctgccgtt aggagtgggc aagtccaccg caaaaccaga ggagctgctc aaggaagtga
3721 ccgatctaga catagtcgtc agacgcacag caggattgaa cgaaaaactg gtattctaca
3781 acaatacccc tttatctctc ctgacgccct ggaaaaagat cctgacaaca gggagtgttt
3841 tcaatgccaa tcaggtgtgc aatgcagtta acctgatccc gctagatacc ccacagagat
3901 tccgcgtggt gtacatgagt ataacgcgtc tatctgacag cggttattac actgtaccaa
3961 ggaagatact agagttcaga tccgccaatg cagtggcctt caacttattg gtcaccctcg
4021 agattgacag ggacactgaa cctggaagac cagcagcggg gggattgggc ctttccgagg
4081 cgacatttat ggtccatgtt gggaacttca gaaggaagaa gaacgaggct tattcagcag
4141 attattgtaa gatgaagatt gagaagatgg gcctagtctt tgcactcgga gggatagggg
4201 gaacaagcct tcacataaga agtactggca aaatgagcaa gacactccac gcacaattgg
4261 gattcaagaa gactttgtgt taccctctga tggatatcaa tgaagacctc aaccggttgc
4321 tgtggagatc cagatgcaag attgttagga ttcaggctgt cttgcaaccg tcagtccctc
4381 aggagtttcg catttatgat gatgtgatca taaatgacga tcaagggctt ttcaaggtcc
4441 tgtaatactc acccagcatc actccacccc cgccgcaccg tcccgcagag acccacagca
4501 gggcagaacg cccgacacca gcctcaaccc agccgaacaa caaggcctag acccccacag
4561 cgcagccccc caccccgaac tcaacacacg gagcacccag ctctgggcag cacccgcacc
4621 ccacctgccc tgcaccccca cctggtccgg acctccccac ggctccgccc accgccgcag
4681 ccgaccaagg cccgaccaac acgcggccgc tgcacatcca gagcgcacac ccgacaacaa
4741 ccccgacagt cccctaccga aaggacaacc ccagacaccc aaccagggcc aacagaggaa
4801 ggaaaccaca ggaaccagac acccccgaga cgaggcaacc tacccaccat gaataccaaa
4861 caaaacttag ggtcaaagaa tcacatcaac ccgaatcgcc ggaagagaca acatcaccga
4921 cacacaacca aaccgggaac caaggggcaa ccacccgcag ggcccagggc ccgggcccac
4981 cacccagagc agcgcagaac cgaaggacag gcccgcccca cgcacagcag cagagcacct
5041 ccagaccccc cacccagagc caccccgacg ccggaccgag cccaagagca cccaggggga
5101 ccctccggtc ccagatcccc aacagcagca ccccccacgc acccccccca ccaccgcccc
5161 cgggactcca cctccacacc acgccagatg ggaacagagg gccccactcc cccgcccccc
5221 tccgcccgag cactcccatc gagaccaccc ccgcacccca acacagcgga ccctggtcac
5281 ccatcgccgc cggagagccg gccaggcgga gcaccaaggg caagccactg ggtcccgcgg
5341 cagatctccc cagccgggca gcccaaggcc accaaatcca tccgagcatc aaaccacggc
5401 atagcgaccg agacactgcc caataaacac acccagatca cccacataat ctctagcatg
5461 aagatcttat ttgctaccct gctagtagtg accacccctc acttagtcac tggccagatc
5521 cactggggca atctttcgaa aattggagtc gtagggacgg gtagtgctag ttacaaggtg
5581 atgacccaat cgagtcacca gacactagtt ataaagctga tgcccaatat caccgctata
5641 gacaactgca ctaagactga gattgaggag tataagaggc tgttggggac agtgcttcag
5701 cctattaagg tcgctctgaa cgccattact aagaatataa aaccaatcag gagttccact
5761 accagtagga gacacagaag gttcgcaggg gtcgctttgg ctggtgcagc tctcggagtt
5821 gcaaccgcag cccagattac agcagggatt gctcttcatc aatcaatgat gaatacccag
5881 gctattgaaa gtcttaaggc aagtctggaa acaactaatc aagcaattga ggaaatacga
5941 caagcaggcc aagaaatgat cctagcagtt caaggtgtcc aggactacat caacaatgaa
6001 ctggtacctg caatgggcca attatcgtgt gatatcgtgg gtcagaagct agggctgaaa
6061 ctgctcagat actacactga aatattatca ttatttggcc ccagcctcag agacccaatt
6121 tcggccgaga tttctatcca ggctttgagt tacgccttag gtggggacat aaacaaaata
6181 ctagaaaagc tagggtatag cgggagtgat ctccttgcta tactggaaag taaaggtatc
6241 aaagctaaga taacctatgt ggatatcgaa agttacttca ttgtgctcag cattgcctat
6301 ccttcgcttt ctgaaattaa aggggtgata attcatcgcc tggagggtgt ctcttacaat
6361 atagggtcgc aggagtggta taccacagta cctcgatatg tggcaaccca aggttacctc
6421 atttcgaatt tcgatgacac accctgtgca ttctccccag agggcactat ctgcagccag
6481 aatgcattat acccaatgag cccactcctc caggaatgtt tccgtgggtc aaccaggtca
6541 tgcgctcgta cactggtctc tgggtctata gggaataggt ttatcctatc caaggggaac
6601 ctcattgcca actgtgcctc aatcttgtgc aagtgttaca ccactggctc aataataagt
6661 caagatcctg acaagatcct aacatatata gctgcagacc aatgccccat cgtagaagtg
6721 gacggtgtaa ccatccaggt tgggagcaga gagtaccctg atgcagtgta cctgcataaa
6781 atagaccttg gcccaccaat atcgctggag aagctagatg ttgggactaa cctcggcaat
6841 gcagtgacaa aactggagaa agccaaggat ctactagatt catctgatct gatcctggaa
6901 accatcaagg gtgcttcagt cacgaacaca ggccatattc tagttggagc cgggttgatt
6961 gcagtagtgg gtatcctcat tgttacctgt tgctgtagga agcgcagtaa tgacagcaaa
7021 gtgtccactg tgatattgaa tccgggtctt aaaccagacc tcactggtac atccaaatcc
7081 tacgtacggt cactgtagta ggtgtgtctc ccatgtgacc actgtccccg aacacctcag
7141 caaagcccac gatgccttat cccctccaca accaatcagc tgccattccc agcaggcacc
7201 ctgtccgttc gcttactaat tgttataaag aaaaacttag gatgcaaggt catcaaccat
7261 gtctccccca agagacaggg tcgacgctta ctacaaggac aacttccaat tcaagaacac
7321 tcgggtggtt cttaataaag agcagctcct gatagagaga ccttgcatgt tgctgacggt
7381 gttgtttgtc atgttcctga gtctagtcgg gctattagct atcgcaggta tcagactcca
7441 tcgagctgct gtcaatacag caaaaatcaa caatgacctg acaacaagta ttgatattac
7501 caaatccatt gagtaccagg tcaaggatgt tttaactcca ctcttcaaaa taattggaga
7561 tgaggtcggg ttgaggacgc ctcagagatt cacagatctg actaaattca tatcagacaa
7621 gatcaagttc cttaaccctg ataaggagta cgactttaga gatatcaact ggtgcatcaa
7681 ccctccagag agaattaaga ttgattatga tcagtattgt gctcacacag cagctgagga
7741 tctgataaca atgcttgtca attcatcctt aacagggact acagtactcc gcacgtcatt
7801 agtcaacttg gggaggaact gtactggacc cacaaccact aagggtcagt tctctaatat
7861 atcattgacc ctttccggga tatactcagg tcgtggctac aacatttcat ctatgatcac
7921 tattactggg aaaggcatgt acgggagcac ttatctggtc gggaaataca atcaaagagc
7981 caggaggcca agcatagtat ggcaacagga ttaccgagtc ttcgaagtag gcataattag
8041 agaactagga gtgggcacac cagtgtttca tatgacaaac tacctggaac ttccaagaca
8101 gccggaattg gagacttgca tgctagccct aggagagtcc aaattagctg ccctctgcct
8161 agctgacagc cccgtcgcac tgcactacgg gagggtagga gacgacaaca agatcagatt
8221 tgtcaaattg ggagtatggg catcaccggc cgaccgagac actttggcca ctctttcagc
8281 aatagacccg acattggacg gactctatat cacaactcat agggggatca tagctgcagg
8341 gactgccata tgggctgtcc ctgtgacgag aacagatgac caagtgaaaa tgggaaagtg
8401 ccgcctagag gcttgtcgag acagaccacc acctttctgt aacagtacag attgggagcc
8461 actagaggct ggccgaatac cggcgtatgg agtactaacc atcaaactag ggctggctga
8521 tgagcctaaa gttgacataa tttcagaatt tggtcctcta atcacccatg actcagggat
8581 ggatttatac acctcatttg acggtaccaa gtactggttg actactcctc cattgcagaa
8641 ctcagctcta ggaactgtga acaccctagt tttagagccc agtctcaaaa ttagtcctaa
8701 catccttact ctccccatca ggtcgggagg gggtgactgt tatactccta cttacctgtc
8761 agaccgggct gacgatgatg ttaaattgag ctccaatctt gtaatcctcc caagtaggga
8821 cctccaatat gtgtctgcaa cctacgacat ctccagagtt gaacatgcca ttgtgtacca
8881 catctatagt accgggcgac tatcatcgta ttactaccct ttcaagttgc ccataaaggg
8941 agatcctgtc agtctgcaga tcgaatgctt cccgtgggac cgcaaactgt ggtgccatca
9001 tttctgctct gttatagatt cagggactgg tgagcaggtc acccatatag gggtagtagg
9061 gattgagatc acttgcaatg ggaaatagtg gtgtctagac tctgcagagg cttataaacc
9121 agggcctccc acaatgacgg gaccaagcac cgcaaagcaa catacaaacg gctaccaaca
9181 ttaccattat aaaaaacgta gggtccaagc tgtatttcac catggactcc ctctctgtta
9241 accaaatttt gtacccggag gtgcaccttg atagcccgat agtgactaac aagctggttg
9301 ccatattaga gtatgcccgg atcccacata agtacgtcct cgaggatcca actctctgca
9361 aaaatataaa gcatcgccta gatagcggtt tttcaaatca gatgatcatc aacaatgttg
9421 agatagggaa tgttgtccaa tccaaactca aaggttatcc gaaccatgag cacatcccat
9481 atccagaatg caaccaagag ttgttcaatg ctcgggataa gaaggctacg gagaaaattc
9541 gatccctgtt taaaaagggg accaccctgt acaccaaaat cagtgataaa gtgtgtacat
9601 gcttagagac tgctaactca agactaggat tgggtgccga cttaggaatt gggatcaagg
9661 agaagatctt gagtctaagc ttgtacatgc agagttccca gtggtatgag ccattcttgt
9721 tctggttcac gatcaagaca gaaatgagat caacaatcaa gtcatcagtc cataccagtc
9781 accgacgaag gtacgtaccc tctttcttct ccggtgactc atttgagatt ctgatttccc
9841 gcgatctagt ggcgatagta cacaggagac tccatcatgt gtattacctg acattcgagt
9901 tggtgttgat gtactgtgat atcatagagg gtaggttgat gactgagact gctatggtca
9961 tagatcccag gtacacagag ctgctggaga gagtccggta tatgtggaaa ctcattgatg
10021 ggtttttccc aactcttgga aattctactt accaagttgt ggctctgtta gagccgcttt
10081 cacttgccta cctccaactg agagatgtaa caacagaatt aagaggtgca ttcctaaatc
10141 attgcttcac tgagatccgt gaaattctta atcagaacgg agtcacagat gacaacacat
10201 accacgagat cgtcgaggcc ctagattata ttttcataac tgatgacatt cacctcacgg
10261 gtgaaatctt ttcattcttt agaagtttcg gccaccccag gcttgaggca atcacagccg
10321 cagacaatgt aaggaaacat atgaaccagc cgaaggtaat agtttatgaa accctgatga
10381 aaggacatgc catattttgc gggattatca tcaacgggta tcgggacagg catggaggga
10441 gctggccacc catccacctc cctgtgcatg ccgccacctc tataaggaat gctcaggctt
10501 cgggtgaagg gttgacgtat gagcagtgtg tcgataactg gaagtcattt gccggtgtaa
10561 ggtttggctg cttcatgccc ctgagtttag acagtgacct tactatgtac ttaaaggaca
10621 aggctctagc agctctcaaa aaggaatggg actccgctta tccgaaagaa ttcctccgct
10681 ataacccacc taagagtact agttcacgga ggctagtcga tgtcttcctc aatgattcga
10741 catttgaccc ttataacatg atcatgtatg tggtgagcgg tgattacctc cgagaccctg
10801 acttcaattc atcttatagc ctaaaggaaa aggaaattaa agagactggg agactctttg
10861 ccaaaatgac ttacaagatg agagcatgtc aggttatagc cgaaaacctg attcccaatg
10921 gtatcgggaa gtattttaga gacaatggga tggcaaaaga tgagcatgac ctcactaaag
10981 ctctccatac attggcagtc tcaggagttc caaaggattt taaagataat taccgcggtg
11041 gacccagggc caagactttc tcctccaaga agacacacac tggggctggt atctcaaggg
11101 tgtctagaaa tgaggcaaac taccggtcac ccgaacaacg aggctgcaac accggtggcc
11161 ccgatcagat agagagttat gaaacagtta gtgcttttat cacagctgat ctgaaaaagt
11221 attgcctgaa ctggaggtat gagacaatca gcttatttgc tcaaaggcta aatgagatat
11281 acgggttacc atccttcttc cagtggttac ataggcgcct tgaaagatca gtattgtatg
11341 tcagtgaccc tcattgtccc cccgatttag atagccacgt gaacttggat aatgtcccga
11401 atgatcagat tttcatcaaa taccctatgg gggggataga aggctattgt caaaaactgt
11461 ggacaattag cactatcccc tatctttact tggctgcaca tgagagcggg gtcaggattg
11521 cctctcttgt ccagggagac aatcagacaa ttgcagtcac caagcgggtc ccaagttcat
11581 ggccttacca ccttaagaaa agagaagctg cacgcgtgac aagagaatat ttctgtctcc
11641 tgaggcaaag actccatgat attggccatc accttaaggc aaacgaaact atcgtgtcat
11701 cacacttctt tgtttactcc aaggggatat attacgacgg actactaatc tcacagtctc
11761 tcaaaagcat tgcacgatgt gtcttctggt cagaaactat agttgatgag acaagagcag
11821 cttgcagcaa catcgccacg actatagcca agagcataga gagagggttt gacaggtacc
11881 ttgcttattc tctgaacatc ctgaaagtta tacaacagat actaatatca ctgggtttca
11941 caataaattc tacaatgaca caagatgtag tggtccctct tctatcaaac catgacctcc
12001 tgataaggat ggccctttta cctgctccaa tcgggggtat gaactactta aacatgagta
12061 ggttatttgt caggaacatc ggggatccag tgacatcgtc tatagctgac ctcaagagga
12121 tgattggtgc gtcactgatg cctgaggaga cacttcatca ggtgatgaca caacaaccag
12181 gtgactcatc atttctcgac tgggctagtg acccctattc tgctaaccta gtatgcattc
12241 aaagcataac aaggcttctc aagaatatca ccgcaaagta tgttctaatc aacagcccca
12301 acccgatgct cagaggttta ttccatgatg acagcaagga agaagatgag caattagcca
12361 cctttctaat ggacaggagt gtaatagtcc cgagagccgc ccacgaaata ttagaccata
12421 gtataactgg agcccgggaa gcaattgcag ggatgctaga tacaactaaa ggactcatca
12481 ggactagctc cagaagaggg ggcctgacca ccagagtgat agcaagacta tccacatatg
12541 actatgagca gtttagatct gggatggtgc ttctaacagg ctcaaagaga aattatctca
12601 ttgatagaga ctcatgctca gtccagctgg ctagggctct gagaagccac atgtgggcca
12661 ggctcgcccg aggaaggccc atatatggct tagaggtgcc ggacgtgcta gaatcaatga
12721 gaggccacct gatccaacgc catgcaacct gcatcttatg tgactttggt tcagccaatt
12781 atggttggtt ttttgtacca tcgaactgtc agttggatga catagataga gagacgtcag
12841 cactcagggt cccctacatc ggatcgacaa cagatgagag gactgatatg aagctcgcat
12901 ttgttaagtc acccagtcga accctgcggt cagctgtgcg gatagccacc gtgtactcat
12961 gggcatacgg agatgacgac aaatcatgga atgaagcttt aaaactagca cagcagaggg
13021 caaaagtgag cctggaggaa ttaaaaatga taactccaat ttcaacatcc accaacctag
13081 cacatagact cagggatcgg agtacccaag ttaagtactc tgggacatct ttggtcagag
13141 tggctcggta tacaacaata tcaaatgata acctatcctt tgtcatctcg gataagaaag
13201 tagatacaaa cttcatctat cagcagggga tgttactagg tttgggtgtc ctcgagacat
13261 tgtttaggct tgataaagac acaggaccct caaacactgt actgcacctc catgtagaaa
13321 cagattgctg cgtgatccct atggtagatc acccgaggat cccaagcttg catgaattga
13381 agttcagaag ggagctatgt accaacccac tgatttatga tagtgcaccc atcatcgaca
13441 gggaagcaac aaaactctat acccaaagtc atcggagaca tctcgtggaa tttgtgacat
13501 ggtctacatc tcagttgtac cacatcttgg caaaatcaac tgcattgtcg atgatagact
13561 tagtgacaaa attcgagaaa gatcatatga acgaggtatc tgctctgata ggagatgatg
13621 atatcaacag ttttataaca gagttcctcc ttgtagagcc tagactgttt accgtctact
13681 taggtcagtg tacagctata aattgggcat ttgacattca ttaccatcga ccttcaggga
13741 aatatcagat gggggaactc ctgacctcat tccttgcaag gatgagtaag agcgtattca
13801 aggtctttgt gaatgcactg agccacccca agatttacag gaagttctgg catagtggga
13861 ttatagagcc aatccatggt ccttcattgg atactcaaaa tcttcatatt actgtatgta
13921 atatgatcta cagttgctat atgacttacc ttgacctact gttgaatgac gaactggacg
13981 agttcacata cctcctctgc gaaagtgatg aggacatagt ggctgaccgc tttgataaca
14041 tacaggctag acatctgtgt gtcctatcgg atttatactg caatcccaga ggatgcccga
14101 ccatcagggg tctacaacca gtagagaaat gtgccatcat gaccaaacac atcgaggccg
14161 aggcaaaact atccctcgct ggcccttcat ggaacatagg ccccattgta attgatcact
14221 tctcttgttc tctgacttac ttaaggcggg gttcgatcaa gcaaattcgg ttgagggttg
14281 atccagggtt catttttgag gctctaactg taacagatcc gcagaaaccc aactttcagc
14341 atgaacaagc cgctgatatg cacataagca attttaggcc gccctatgat ggtgtggcag
14401 agctgttagg gacgataaac tcgagtaagc ataaccttcc tatacttggc acaggtgttt
14461 ataattacga ggtccatgcg tttcgcagga taggattaaa ctcgtctgct tgttacaagg
14521 cagtggagat atccacgcta atcaagagct ctatggaccc agaagaggat agcttgttct
14581 taggggaagg atcagggtca atgttgataa cgtataaaga aatccttaaa ttaaagaagt
14641 gcttttacaa cagcggggtg tcagcagaat ctagatcagg ccagcgagag ttagcccctt
14701 acccatctga ggtaagcctg gtcgaacatc agcttggtgc agagaaaact gtcaaagtac
14761 tattcaacgg gaggcccgag gttacctgga taggtagtgt agattgcttc aattatatca
14821 tcagcaatat acagacatct agccttggcc taatacactc agacatagaa accctcccta
14881 caaaagatat cacagagaaa ttggaagagt tgtcagctat cctagcgttg gctctattgc
14941 taggtaaggt aggttcagta ttggttatca aagtaatgcc tataagtgga gactatgtcc
15001 aggggttcat gagttatgtg gtgccttatt acagagaggt actcatcatc tacccgagat
15061 atagtaactt catatcaact gaggcatatc tagtcctgtt gggactcagg gccaatagac
15121 tgatagatcc tgaaagaatt aaacaacagg tgatggaatc cgggatcaga actatccccg
15181 gtttagtcgg acatatatta tccatcaagc agctcaattg catacaaagc caggcggggc
15241 cagctatcac tagaggtgag ataaacccga tattaagaaa gctcacacct atcgagcgta
15301 ttctgatcag ctgcgggctt accatcaacg gcacaaagat ttgcagtgat gtagtccacc
15361 atgatatatc atcagggccg gacggtctgc ttaattcttc tatcattctg ctcaaggagt
15421 tggccagatt cagggataat caaaggagtc agcaggggat gttccatgct taccccgttc
15481 tgctgagcag caggcagcgt gaactgatct ccagggttgc tagaaagttt tggggttaca
15541 ttctcttata ctccagcgat aggagactac taagtaggct ggtgagtaat ctcaagtctg
15601 gatacctttt gtttgatctt catcagaact tgttcatgaa aaacctgtca aagtctgaga
15661 agcagctgat cagaacagga gggctcaagc gtgagtggct ttttaaactc actacgaaag
15721 agatcaaaga gtggttcaag ctaataggtt acagtgcact cattcgggag tgattctgca
15781 actgtctgct tcccgatcct gatctggtca ataaaactgt agaaataata tactaaagaa
15841 aacttcaaag aagtgaagtt tctatcccca gctttgtctg gt
//
