LOCUS NC_034968 14964 bp ss-RNA linear VRL 13-AUG-2018
DEFINITION Avian paramyxovirus 15 isolate
APMV-15/calidris_fuscicollis/Brazil/RS-1177/2012, partial genome.
ACCESSION NC_034968
VERSION NC_034968.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Avian paramyxovirus 15
ORGANISM Avian paramyxovirus 15
Viruses; Riboviria; Orthornavirae; Negarnaviricota;
Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae;
Avulavirinae; Metaavulavirus; Metaavulavirus peixense.
REFERENCE 1 (bases 1 to 14964)
AUTHORS Thomazelli,L.M., de Araujo,J., Fabrizio,T., Walker,D., Reischak,D.,
Ometto,T., Barbosa,C.M., Petry,M.V., Webby,R.J. and Durigon,E.L.
TITLE Novel avian paramyxovirus (APMV-15) isolated from a migratory bird
in South America
JOURNAL PLoS ONE 12 (5), E0177214 (2017)
PUBMED 28486490
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 14964)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (13-JUN-2017) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 14964)
AUTHORS Thomazelli,L.M., Araujo,J., Fabrizio,T., Walker,D., Ometto,T.,
Barbosa,C.M., Petry,M.V., Webby,R.J. and Durigon,E.L.
TITLE Direct Submission
JOURNAL Submitted (31-MAY-2017) Depto Microbiologia, Instituto de Ciencias
Biomedicas, Universidade de Sao Paulo, Av. Prof. Lineu Prestes,
1374, Sao Paulo, SP 05508000, Brazil
REMARK Sequence update by submitter
REFERENCE 4 (bases 1 to 14964)
AUTHORS Thomazelli,L.M., Araujo,J., Fabrizio,T., Walker,D., Ometto,T.,
Barbosa,C.M., Petry,M.V., Webby,R.J. and Durigon,E.L.
TITLE Direct Submission
JOURNAL Submitted (30-SEP-2016) Depto Microbiologia, Instituto de Ciencias
Biomedicas, Universidade de Sao Paulo, Av. Prof. Lineu Prestes,
1374, Sao Paulo, SP 05508000, Brazil
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to KX932454.
##Assembly-Data-START##
Assembly Method :: De Novo assembly in CLC Genomics Workbench
v. 9.0.1
Sequencing Technology :: Illumina
##Assembly-Data-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..14964
/organism="Avian paramyxovirus 15"
/mol_type="genomic RNA"
/isolate="APMV-15/calidris_fuscicollis/Brazil/RS-
1177/2012"
/isolation_source="oral/traqueal swab"
/host="Calidris fuscicollis"
/db_xref="taxon:1983777"
/country="Brazil: Parque Nacional da Lagoa do Peixe, RS"
/collection_date="Apr-2012"
gene 85..1452
/gene="NP"
/locus_tag="CDH63_gp1"
/db_xref="GeneID:33133686"
CDS 85..1452
/gene="NP"
/locus_tag="CDH63_gp1"
/codon_start=1
/product="nucleocapsid"
/protein_id="YP_009380504.1"
/db_xref="GeneID:33133686"
/translation="MSSVFSDYQALQEQLVKPTTRRMDAGSTGLLKAEIPVCVTLSND
PRERWNLACINLRWLISESSTMPMRQGAIISILSLHSDNMRAHATLASKAADAAITVL
EVDNVDLQNGILAFNPRSGVPDKRAQQLLAIADDLPKSCPNNSPLVTRDIEESEPLDL
SETIERLQGIAIQVWVAAIKSMTAPDTASESESKRLAKYQQQGRLMKQVMLHNSVRQE
FLRVIRSSLVIRHFMINECRRAATMGNNTSRYYAIVGDISLYFKNAGLTAFFLTLKFG
VGTKYPTLAMSALSGELKKLAALIKLYRNKGEDAAYMAFLEDPDMGHFAPANYSTIYS
YAMGVGTVLESSVTKYQFAREFTSETFFRLGVETAQSQQASIDETTAVEMGLTREARN
QVKILVENLDLSAGSDIQTSAPQFLDESDSQPQVNSRSIPTTTKNSTPAKPSNPDGDD
LSMDW"
misc_feature 283..>1251
/gene="NP"
/locus_tag="CDH63_gp1"
/note="Paramyxovirus nucleocapsid protein; Region:
Paramyxo_ncap; pfam00973"
/db_xref="CDD:395775"
gene 1624..2871
/gene="P"
/locus_tag="CDH63_gp2"
/db_xref="GeneID:33133681"
CDS 1624..2871
/gene="P"
/locus_tag="CDH63_gp2"
/codon_start=1
/product="phosphoprotein"
/protein_id="YP_009380505.1"
/db_xref="GeneID:33133681"
/translation="MEFKSDEEINDLLNLSSSVISELQRAELKPPQTLGKPQVPSGNT
TSLISLWEAEGAPENKLGRGNTGTATDTEGEQDQQIVQTEIEQTHTEDTCPKEIPVDN
PGSFTQESDLDKTLKKLEQRNSNLLKKTDSPDAGTTFKKGGQIAPKHQPLPSQVIEGN
LPPQDCRQSRPSRTDASQRPSTTPKGAHPQLHPFQDIEENTQSVPLDHPLKLLVGATP
DVHQFEQSQGENGAHVGNVLESASFAEMTLSVLNEVLIRVARMEEKINDILKTNSTIP
LIRNDISQLKATTALLSTQMASVQVLDPGNAGFKSLSEMKAASKPAIIAISGPGDMDA
VPIQDKLLVKDVLGRPISAERNIQAKETPDSVITQSDKDAIQSLIDTLVEDTSKQARL
KAQLERVQDKPGLLKLKRLIYNA"
misc_feature 1624..1794
/gene="P"
/locus_tag="CDH63_gp2"
/note="N-terminal region of Paramyxovirinae phosphoprotein
(P); Region: Soyouz_module; pfam14313"
/db_xref="CDD:316803"
misc_feature 2401..2859
/gene="P"
/locus_tag="CDH63_gp2"
/note="C-terminal domain of Measles virus phosphoprotein
and related proteins; Region: MEV_P-protein-C_like;
cl03936"
/db_xref="CDD:413868"
gene 3133..4257
/gene="M"
/locus_tag="CDH63_gp3"
/db_xref="GeneID:33133682"
CDS 3133..4257
/gene="M"
/locus_tag="CDH63_gp3"
/codon_start=1
/product="matrix protein"
/protein_id="YP_009380506.1"
/db_xref="GeneID:33133682"
/translation="MASTSIPLHINQSDPSSELLSFPLIFTNNDSGSKTLQPQVRFSQ
LGDIQGGKDETVFITLYGFIQTEQDSLDLTHNQSTFQVLGQTSKPDTITAACIPLGAT
TLRSTITRMAEESLELLILVKKSAVSSEKLAVSFINIPPSLAGILVIRAGGFILSAEE
YVKSPSKLQAGYQYKFKPVFITCTRIFKGKLYKVPKSMHYIASELLYKAVLEIQFQLD
IKPDHPQTKMLKKQDTNEGPEYYGFVWFHLLNFKKTTARGEIRTLEKISDKIRAMGIK
VSLYDLWGPTILAEITGKKSKYAQGFFSLNGCACLPVARASPEIAKLIWSCSTRIKSA
TIIVQSSDKRGLLNSEDLEIKGAVGVSPRKLGSYSLFKKH"
misc_feature 3178..4203
/gene="M"
/locus_tag="CDH63_gp3"
/note="Viral matrix protein; Region: Matrix; pfam00661"
/db_xref="CDD:395535"
gene 4456..6084
/gene="F"
/locus_tag="CDH63_gp4"
/db_xref="GeneID:33133683"
CDS 4456..6084
/gene="F"
/locus_tag="CDH63_gp4"
/codon_start=1
/product="fusion protein"
/protein_id="YP_009380507.1"
/db_xref="GeneID:33133683"
/translation="MYVPGVILALLMINPCLTLDNSKLAPVGIISAAEHELAIYTNTL
SGSIAVRFLPNLPANLTHCQKTILDNYNVTVTRILKPIADNLNILKHGLEVPKERLVG
AIIGTVALGVATSAQITAAVAVAQAQQNAKDIWKLKNAILSTNEAVLELKTGLQQTAI
ALDKIQDYINNEIIPTVNNLTCEVMANRLGVYLSLYLTELTTVFGNQITNPALSTISY
QGLTNLCGNNIGALTKLIGLKDDNVESIYEAGLITGQVVDYDPASQILIIQVSYPSIS
RLSDIRATELITVGVTTPFGEGRAIVPKYVAQSTVLIEELDISSCKFSSTTLYCTQIN
TRPLPPRVSSCLKGDYENCQFTTEVGVLASRYASIGKGVVVNCRSIICKCLEPPRIIP
QNSLASITVIDSKICKKLQLPDVILRLDGNLESQYFTNISINGGQVTPSGPLDISSEI
GNINQTVNRVEDLIHESESWLSRVNPKLISNTAIIVLCVLSSLCVLWLILITAFMAKL
LSNVKKIERKVAVSSLIGNPYVYTNPGYSGSKSA"
misc_feature 4513..5910
/gene="F"
/locus_tag="CDH63_gp4"
/note="Fusion glycoprotein F0; Region: Fusion_gly;
pfam00523"
/db_xref="CDD:395418"
gene 6304..8043
/gene="HN"
/locus_tag="CDH63_gp5"
/db_xref="GeneID:33133684"
CDS 6304..8043
/gene="HN"
/locus_tag="CDH63_gp5"
/codon_start=1
/product="hemagglutinin-neuraminidase"
/protein_id="YP_009380508.1"
/db_xref="GeneID:33133684"
/translation="MNSSYSQDNLYTNQTAAQPRGTWRVLYRAVSLIFQILIFSLVLT
NVIQYSNLHSPSVSEISAATTTETIDGLKPHLETPLNQINDIFRLTALDLPIQMNTMT
REITSQLNILTSGINELVTSNNSGRLLQTTDPAYTGGIGVFVLNNYLDYPPNLQNMSL
LEQPNFVPGSTTTGGCTRIPTFHLSSTHWCYSHNIIEKGCHDAGHSSMYISIGVVQVS
SRGVPVFLTTQSVIVDDETNRKSCSIVSTEYGCDILCSIVTERESDDYKSDPPTRMLH
GRLLFNGSYVEAAVKFTNDINKFSANYPGVGSGILLGNKILFPLYGGIKQSTDLFNYL
HNRTAQVSNNKTVCSTGYDKKKLEAAYRPPLIGGRFWAIGIVICKFSINSLGDCRYKI
YDSSVVMMGSENRLMKVGNQVFLYQRSSSWWPIGLTYILNSTDLLNTDSDIVSSIIPI
YHTKFPRPTYDRNACTRPNVCPATCIEGVYADIWPLNNPAEPSKIIWVSHYLNSEVGR
EFPAIGVANQYEWVKEFRPLPPTTGAAYATTSCFKNTISNRIFCVSVAEFKDNLFGQF
RIVPLLYEIKVIN"
misc_feature 6793..8025
/gene="HN"
/locus_tag="CDH63_gp5"
/note="Hemagglutinin-neuraminidase (HN) of parainfluenza
virus 5, Newcastle disease virus, and related
paramyxoviridiae; Region: HN; cd15469"
/db_xref="CDD:271233"
misc_feature order(6805..6822,6892..6894,6928..6930,6955..6957,
6961..6963,6997..6999,7003..7005,7981..7992,8002..8004,
8008..8016)
/gene="HN"
/locus_tag="CDH63_gp5"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:271233"
misc_feature 6832..7008
/gene="HN"
/locus_tag="CDH63_gp5"
/note="Sialidase propeller 1 [structural motif]; Region:
Sialidase propeller 1"
/db_xref="CDD:271233"
misc_feature order(6835..6837,6907..6909,7510..7512,7555..7557,
7825..7827,7909..7911,7972..7974)
/gene="HN"
/locus_tag="CDH63_gp5"
/note="active site"
/db_xref="CDD:271233"
misc_feature order(6835..6837,7087..7089,7210..7212,7264..7266,
7396..7401,7510..7512,7555..7557,7561..7563,7729..7731,
7825..7827,7909..7911)
/gene="HN"
/locus_tag="CDH63_gp5"
/note="receptor binding site [chemical binding]; other
site"
/db_xref="CDD:271233"
misc_feature 7015..7173
/gene="HN"
/locus_tag="CDH63_gp5"
/note="Sialidase propeller 2 [structural motif]; Region:
Sialidase propeller 2"
/db_xref="CDD:271233"
misc_feature 7198..7497
/gene="HN"
/locus_tag="CDH63_gp5"
/note="Sialidase propeller 3 [structural motif]; Region:
Sialidase propeller 3"
/db_xref="CDD:271233"
misc_feature 7501..7662
/gene="HN"
/locus_tag="CDH63_gp5"
/note="Sialidase propeller 4 [structural motif]; Region:
Sialidase propeller 4"
/db_xref="CDD:271233"
misc_feature 7735..7884
/gene="HN"
/locus_tag="CDH63_gp5"
/note="Sialidase propeller 5 [structural motif]; Region:
Sialidase propeller 5"
/db_xref="CDD:271233"
misc_feature 7903..8025
/gene="HN"
/locus_tag="CDH63_gp5"
/note="Sialidase propeller 6 [structural motif]; Region:
Sialidase propeller 6"
/db_xref="CDD:271233"
gene 8314..14964
/gene="L"
/locus_tag="CDH63_gp6"
/db_xref="GeneID:33133685"
CDS 8314..14964
/gene="L"
/locus_tag="CDH63_gp6"
/codon_start=1
/product="polymerase protein"
/protein_id="YP_009380509.1"
/db_xref="GeneID:33133685"
/translation="MDQRQSDNIIHPEVHLDSPLVKNKLALLWKLLGLPLPKDLQDIE
LINLTTEADFLRQEQTIKDKLLALRDLSTKHLKRHGLLWNHIEPVCHPRTLSWLLKLE
CSKAQHLRAKREQVINQSFKEHGTNIQHLFTSLSHKLISNSGLFSSGDQPQESPLPAI
SSGAKTLITSYRAAVNTEWSEGRWCWLHVKQVMRYLMYQSRIHKHSTNIKVWSEKSNI
IGVTPDVVVVINVLRKIYTVLTFEMVLMYSDTAEGRDNAIVVGRLSPFLQLVVDKLGI
LFELIDSLAIEIGEKIYDVIATLESMAYASVQLHDASIVQAGEFLSFNLSELVETLNS
LIDPAQAKRIIEIIRLCYTGLSVDQSAELLCLMRLFGHPLLSAKDAAKKVRESMCSPK
VVEFDTILQTLSFFKGILINGYRRAHSGIWPNIDPDTILDEDIRQLYLESSEIPHSIM
LRKYQALSLLEFKKSIDFDLSADLSAYLKDKAICRPKPQWSAIFRKSLVGKSRQMNNS
TDIRSNRLLIDFLESDDFDPYQEFNYVVSMDYLKDPDFCASYSLKEKEIKTTGRIFAK
MTRKMRSCQVLLESLLSKHICKFFKENGVSMEQLSLTKSLLSMSQLAPRISTLGLRPI
RNNRTRPKYDEKNESSANFSGDPRGALVRDKTVVATFLTTDLQKYCLNWRYSSIKLFA
QALNQLFGLDHGFEWIHLRLMDSTMFVGDPYSPPESALYTDLDDAPNDDIFIVSARGG
IEGLCQKLWTMISISIIHCVAEKIGARVAAMVQGDNQVIAITRELYSGDSAESLLDEL
DHLSDQYFAEFKRHNYGIGHNLKLKETIRSHSFFVYSKRVFWEGRILSQILKNATKLC
YIADHVGENSVSSCSNLSSTIARLVENGYEKDTAFILNQSYLMNQLMIDEQYTLTCDY
SEARRLIGTDNYRNLFYATLIPGQVGGYNFLNISRLFTRNIGDPVTSAISDIKWYIKS
NLLPRRVLKNLILREPGDGGWATLCADPYALNIQYTQLPTTYLKKHTQRTLLASASNP
LLSGVQIPSQHIEEELLAQFLLDREAVMPRVAHVIMESSILGRRKQIQGLIDTTPTII
KTALMHHPVSRRKTEKIVNYSIDYLTACHDFIIAQIEFPTSKEEMWENNFVDEDTCSV
IIAEFLRAVSWRNLLNGRIIQGVTSPDTIELITGSLIGENSYCRLCASGDNNYTWMFL
PGPTNITSPYVSSSKIRVPYLGSKTEERRTASMATVKGMSHHLKAALRGASVYIWAFG
DTEQNWEDALKIVSTRCNISINQLKLLTPTPSSSNIQHRLADGISVQKFTPAGLSRVS
SFVHICNDAQKLEKDDGQVDSNLIYQQIMLTGLAVFETIHPMNIEWVSYNQTLHLHTG
LSCCTREVEGSLVNPPSHELGEITITQQNKFLFDSEPIPEIENIKIALKEFKVMEINL
DGLSGYDSIKLLSKCTARLICECINEEGVSSSVKNDAVISFDNTINWISETLMCDIHY
LVTCIGQEILTQLAYQIYYLRIRGLNSILAYIESTLERIPVIQLANFALTISHHEIWR
RLELTGLRCNARVAYLANVDFIGASRDVILYGCRLYLQGLLIQEEPSYLFFDVCDGDL
NAKMEQFLARRLCIIVSLIGTTLNYPIIRQESPIQKCVTLSDFIETISVSDARCAATA
RVLQTVALSPSIDTVPTNLYYTTRRVLSNIRSSEISRAQITYLYNEDIPTHYDELGID
PVTTDDPIIQRGLFFNVELTADKLSTHVLPSVCGLLNDTSVPLNMEYDKPGFLITQLT
KSVGTSSTSWYKFAVWYATRMRQSVILGDSMYVGEGSGCVMTLFEYLDPSNNIFYNSL
FSSDMNPPQRNYGLSPYQFERSIVYKNILAGASSKYGFTQEFHKLWREIDAETNISEP
AFMNYALEVIKPHSCKRIVCDAEFDSGMPEERIIQAYTHIILLSSYALTKHGLILLKL
HCTSERITQFVFSSLLMIFGRVQIHRNGYMNLNNQEILVSATLGEVINYVSIPPILTR
IKALFDSGLTIIHPDNLRRIRTQEESLRIKLQQLERNVLSKAVKLQLCKTDILLLHLG
GSLIQPGQINIQELREKSAGELQKEIIELIDTAISEINVIKNEAVDLDIALMMSPYNI
NKSRKIATIARICTRRVIPIWLIMSIQLNSSSLASVCAVLERGVISWETCMTSREYIS
CSTRPRFIKKIIGASTVERLFKTCLL"
misc_feature 8350..11655
/gene="L"
/locus_tag="CDH63_gp6"
/note="Mononegavirales RNA dependent RNA polymerase;
Region: Mononeg_RNA_pol; pfam00946"
/db_xref="CDD:395756"
misc_feature 12049..14952
/gene="L"
/locus_tag="CDH63_gp6"
/note="mRNA capping enzyme, paramyxovirus family; Region:
paramyx_RNAcap; TIGR04198"
/db_xref="CDD:275046"
ORIGIN
1 atcttggggg cgacccttgc tgatcgagag ctcgattccg aaggcaaata tttgatatag
61 gaacaacctt cattatctag aatcatgtca tctgtattta gtgattatca agctctccag
121 gagcaacttg tcaagcctac cactaggcgg atggatgcag gttcaactgg attacttaaa
181 gcagaaatcc ctgtgtgtgt gacactatct aatgacccaa gagagagatg gaatctagcc
241 tgtataaatc ttcgatggtt aatcagtgag tcttccacaa tgccaatgag acaaggtgca
301 atcatctcaa ttttgagcct ccattctgat aatatgaggg ctcatgccac acttgcatct
361 aaggcagcag atgcagcaat caccgtcctt gaggtggaca atgtagatct ccagaatgga
421 attctggcat ttaaccccag gagcggagtc ccagacaaaa gagctcaaca gctgttggcc
481 attgcagatg acttaccaaa gtcatgccct aacaatagtc ctttggtgac acgagacatt
541 gaggaaagtg agccattgga cttgtctgaa accattgaaa ggctacaagg gattgccatc
601 caagtctggg tggccgcaat taagagcatg actgccccag atacagcatc agaatctgaa
661 agtaaaagat tagctaaata ccagcagcaa ggtagattga tgaagcaggt tatgctgcac
721 aattcagtac gccaagaatt cttaagagtg atcaggagta gcttggttat caggcacttc
781 atgattaatg aatgcaggag ggcagcaaca atggggaata acacatctag atactatgcc
841 attgtcggag acatcagcct ctactttaag aatgcaggat tgacagcctt ctttctcaca
901 ctgaaatttg gagtagggac aaaatacccg acattagcaa tgagcgcatt atctggtgaa
961 ctcaagaagc tagctgcact cattaaatta tataggaaca aaggcgagga tgcagcatac
1021 atggctttcc tagaggaccc agacatgggt cactttgctc ctgcaaatta tagcacaatc
1081 tactcttatg ctatgggagt gggtacagtg ctggagtcat cagtcacaaa ataccaattt
1141 gcgagggaat tcaccagtga aacatttttt agactgggtg ttgaaacagc acaaagccag
1201 caggcttcta ttgatgaaac cactgcagta gaaatgggtc ttacgagaga agcaaggaat
1261 caagttaaga ttctcgtaga gaatcttgac ctctcagctg gatcggatat ccaaaccagc
1321 gcccctcaat tcttagatga aagcgacagt cagcctcagg tcaattcaag aagcattccg
1381 accacaacca aaaactcaac acctgccaag cccagcaatc cagatgggga tgatctgtca
1441 atggactggt aatctacatc ccctcaaatt agccagtcaa aacgatcctg atctgagtga
1501 gataatctat tgaaattaat tctatgtttt gtgatttaag aaaaaataat ttgggggcga
1561 cccttctaat caccagcgca agtcatcact ctgtatccca atcacaatca agacccattc
1621 atcatggaat ttaaatcaga tgaggaaatc aatgatctac ttaatctcag ttcttctgta
1681 atcagtgaac ttcaaagagc tgagctaaag ccgcctcaga cactaggtaa gcctcaagtt
1741 ccatcaggga acacaacttc cctgatatct ctgtgggagg ctgagggtgc ccccgagaac
1801 aagctcggaa gaggcaacac tgggacagcc actgacactg aaggagaaca agaccaacaa
1861 attgtccaaa ctgaaataga gcaaacccac accgaagaca cttgtccaaa agaaatccca
1921 gtagacaacc caggaagctt cacgcaggag tcagacttag ataagacact taagaaactt
1981 gaacaacgga actcaaatct gctgaagaaa acggattcac cagatgcagg cacaactttt
2041 aaaaaggggg gacaaatagc tcccaaacat caaccactac cctcgcaggt catagaaggg
2101 aacctccctc ctcaggactg ccgacaatcc cgaccaagtc gcacagatgc atctcagaga
2161 ccctctacca ccccaaaagg ggctcatcca caactccacc ctttccagga catagaagag
2221 aatactcaat cagtaccact ggatcatcca ttgaagttat tagttggtgc aacccccgat
2281 gtgcaccaat tcgagcaatc ccaaggcgag aatggtgcac atgtgggaaa tgtcctggag
2341 agtgcctcct ttgccgagat gacattaagt gtcctaaatg aagtgctgat tagagttgcc
2401 aggatggaag aaaagatcaa tgacatactt aaaaccaact ctactattcc gttgataaga
2461 aatgatatca gccaacttaa ggcaacgacg gctcttctaa gcactcaaat ggcatcagtg
2521 caagtactag atcccgggaa tgcaggattc aagtcattaa gcgagatgaa ggcagcatca
2581 aagccagcta ttatagcaat ctctggcccg ggtgacatgg atgcagtacc cattcaagac
2641 aaattactag tcaaagacgt gttagggaga cccatctcag cggagaggaa cattcaggca
2701 aaagagacac cagatagcgt aattactcag tcagacaaag atgcgatcca gtctctaatt
2761 gatacacttg tcgaagatac atctaaacaa gccagactga aggcacaact ggagagagtg
2821 caggataagc cagggctact gaaactcaaa cgattgatat ataatgcgta aaatattgag
2881 aacaacttca aaatacacac tcccaatagc caagtgcatc agctgatcat aatcaatatc
2941 gattcaatcc aattcaagct aagaagagcc cagattcatg ccagacacgc agctccagct
3001 tcctcactgg acagcaagtc agccaacatg ttatcggatc atgttccaaa ccagatcaat
3061 taagaaaaaa caataatcgg gggcgaccta ctcaaaataa gcaacccaca accagactca
3121 cacaccgatt caatggcatc aacctcaatc ccgcttcata tcaatcagtc agatccatca
3181 tctgaacttc tatcattccc tttaatattc acgaataatg actctggtag caagacactt
3241 caaccgcagg taagattcag tcaactcggc gatatacagg gtgggaaaga tgaaacggtg
3301 ttcataacgc tctatggatt tattcagaca gagcaagact ctcttgatct cacacacaat
3361 caaagcacat ttcaagtcct gggtcaaaca tcaaaaccag acaccattac tgctgcatgc
3421 atccctcttg gagcaaccac tctacgaagt acaatcacta gaatggcgga agagtcacta
3481 gagctgttga ttctggtgaa gaagtcagca gtgtcgagcg agaagctagc tgtgtcattc
3541 atcaacattc caccatcact tgctggaata ttagtcatca gagcgggggg atttattcta
3601 agtgcagaag aatatgtcaa atcaccaagt aaattgcaag cagggtatca gtataaattc
3661 aagcctgttt ttatcacctg cactaggatt ttcaaaggga agctctataa ggtacccaag
3721 tcaatgcatt atatagcatc tgagcttctc tataaggctg tattagaaat acaatttcaa
3781 ctggatataa aacccgacca tccacaaaca aaaatgctga agaaacaaga cacaaatgaa
3841 gggcctgaat attatggctt tgtttggttt cacctcctta attttaagaa aacaactgct
3901 agaggtgaga ttcgcacact tgagaaaatc tcagataaaa ttcgtgcaat gggaataaaa
3961 gtgtcccttt atgacctttg gggcccaaca attcttgctg agatcactgg gaagaaaagc
4021 aaatatgccc agggattctt ttctttgaat ggatgtgcat gcctgccagt tgccagggcg
4081 tctcctgaaa tagcaaagtt gatttggtca tgttccacga gaattaagag tgcaactatc
4141 attgtccagt cctccgataa gagaggactt cttaattccg aggatctcga gataaagggt
4201 gcggttggag tcagtcctcg caaattaggc tcatacagcc tctttaagaa acattgagtg
4261 ttgaattcag aatcgaaaat caaggttaaa aaaataggct gtaagttgat aattgaagtc
4321 tgatcgatag tcacatatta ggacctacag gataactcat gatttaggga atattgattc
4381 agggtttata aaaaacctgg gggcgacatc tcactcaaag ctaggcaaca accaatatac
4441 aaaaaccatt ccagaatgta tgtaccaggt gtaattctag ctctcttgat gatcaatccc
4501 tgtctaactc tagacaattc taagctagca cccgtgggta ttattagtgc tgcggagcat
4561 gagttggcta tatatacgaa tacactctct ggctctattg ctgtcagatt cctgcccaat
4621 ttgccagcta atcttacaca ttgtcagaag acaatcttag ataactacaa tgtaactgtg
4681 acacgcattt tgaagccgat tgcggataat ctgaatatac tcaagcatgg attagaagtt
4741 ccaaaagaga gattagtagg tgctatcata ggcactgttg ctcttggtgt ggccacatca
4801 gctcaaatca cagctgcagt tgcagttgcc caagctcagc agaatgcaaa agatatctgg
4861 aagcttaaaa atgcaatcct tagtactaat gaggctgtac tagaattaaa gacaggcttg
4921 caacaaactg ccatcgcact agacaaaata caggattata tcaataatga gattatacca
4981 acagttaata atttaacctg tgaagtgatg gcaaacagac ttggtgtata tttgtccttg
5041 tatttgacgg agctaaccac agtatttggg aatcaaataa ccaatcctgc cctcagcaca
5101 atttcatatc aaggactgac gaatttgtgt gggaataata ttggagcact gacaaaatta
5161 atagggttaa aagatgataa tgtagaatca atatatgaag cgggattaat aactggtcaa
5221 gtagttgact atgaccctgc aagtcaaatc ttaatcatcc aggttagtta tccaagtata
5281 tcaagattga gtgatataag agctactgag ttaatcactg ttggtgtgac aactcctttt
5341 ggtgaaggaa gggcaattgt cccgaagtat gtagcacaga gcactgtatt aattgaggag
5401 ttggacatct catcttgtaa attcagttca actacattat actgtactca gattaatact
5461 cgcccgttac ctccgagagt atcaagctgc cttaaaggtg attatgagaa ttgtcagttt
5521 acaacagaag tgggggtgct tgcatctagg tatgcatcta tagggaaggg agtagtagtc
5581 aattgcagat caattatatg taaatgttta gagcctccta gaattatacc tcagaatagc
5641 ttggcatcta taacagtcat agatagcaag atctgtaaga agctccaatt acctgatgtt
5701 atattgcgtc tagatggtaa cctcgaatct cagtatttca ctaatatatc aatcaatggt
5761 gggcaagtga ccccttctgg gccacttgat attagcagtg agatagggaa catcaatcaa
5821 actgtaaatc gagttgagga tttgattcat gaatctgaaa gctggctgtc tcgagtcaat
5881 cccaagctaa tatcaaacac agcaatcatt gttctctgtg tcttatcatc gctgtgtgtg
5941 ctttggctta tattaatcac tgcattcatg gctaaattac taagtaatgt taaaaagata
6001 gaaaggaagg tagcggtatc ttccctaata ggtaatcctt atgtttatac caatcctggc
6061 tattcaggtt ctaagagcgc atgatcagaa gccaaaccta ttcagttaaa taaactccga
6121 tcagcatgac actttaaacc gctcacattg ttaatatcta aatacttggt aatttaataa
6181 aaaacagctt aaaattattg gaaagctggg ggcgacctct ctatttagta agatagattc
6241 gtcgttaact cctgtttaaa tttcgattgt atcactcccc aagtagatct catatctaca
6301 gtcatgaatt caagttactc tcaagataat ttatatacaa atcaaactgc tgctcaacct
6361 agaggaactt ggagagttct ttatagggcc gtatcattga tattccagat attaatcttc
6421 tcactagtac tgacaaatgt catccaatat tcaaatctcc atagcccctc tgtgtcagag
6481 atttctgcag ccactacaac tgagaccatt gatgggttaa aaccacactt agaaactcca
6541 cttaaccaga taaatgacat ctttcgctta actgcccttg acttgcccat acagatgaac
6601 acgatgactc gagaaatcac aagtcaactc aatatcctga ccagtggaat taatgagctt
6661 gttacctcga ataattcggg aagacttctc cagactacag accctgcata tacaggtggt
6721 attggagtct ttgtgctcaa taattactta gattatccac cgaatctgca gaacatgtca
6781 ttattagagc agcctaattt tgtacccggt tctaccacca ctgggggttg tacacggatt
6841 cccactttcc atttgtcatc aactcattgg tgttattctc ataacatcat tgagaaaggc
6901 tgccatgatg caggacactc gagtatgtac atatctattg gtgtggtcca agtatcctca
6961 cgcggtgttc cagtgtttct gacgactcag agtgtaattg ttgacgacga aaccaaccga
7021 aaatcctgta gcattgtgtc aactgaatat ggttgtgata tattatgcag catagttact
7081 gagcgtgagt cagatgacta taaatcagat ccacctacta gaatgctaca tggtagactc
7141 ttgttcaacg gctcttatgt agaagctgct gtcaaattca ccaatgacat caataaattc
7201 tccgcaaatt acccgggagt cggttcagga atcctcctag gcaataaaat tctattccct
7261 ctgtatggag gcataaagca gagtacagat ttgtttaatt acttacacaa caggactgct
7321 caagtatcaa acaataaaac agtatgtagc accggttatg ataaaaagaa actagaagct
7381 gcatatcgac cgccactaat tggagggaga ttttgggcaa tcgggatagt tatatgtaag
7441 ttcagcataa attcacttgg agattgcaga tacaaaatat atgacagcag cgtagtcatg
7501 atgggttcag aaaatcgcct catgaaggta ggcaatcagg tattcttgta tcagagatcc
7561 agctcatggt ggcctattgg attgacctac atactcaata gcactgactt gcttaacacc
7621 gattctgaca tagtcagcag tataatcccc atatatcata caaaattccc gcgccctact
7681 tatgatagga atgcatgcac tagaccaaac gtttgtcctg ccacatgcat agaaggtgtt
7741 tatgcagata tttggccact taataatccg gcagaaccga gtaaaattat atgggtcagt
7801 cattatctca attcagaagt agggagagaa ttccctgcta tcggtgttgc caaccaatat
7861 gaatgggtaa aagaatttcg tccacttcca cccacaacag gtgcagcgta tgcaactact
7921 tcttgtttta agaatacaat aagcaaccgc atcttctgtg ttagtgtagc tgaattcaag
7981 gacaatttat ttgggcaatt cagaatcgta ccgcttctat atgagattaa agtaatcaac
8041 taaccatcat aacccaacta tgggtaacac tttgaataac actttaaggt agatctacaa
8101 catggatgac acaaattctc cacgtttgtg gacactcaag caaatcttcc atgtcgaaat
8161 caagctacaa acttcaatat agggaatgat tactagtcat gtattgccta acccttatct
8221 ccaaaggggt tatccctaaa tcacatgcag atcctagaat gcacttgtca acatttaaga
8281 aaaaactaaa ttgggggcga ccctctaaca actatggatc agcgtcaatc cgataatatt
8341 atccatccag aagttcacct tgattcaccc ctggtaaaaa ataaattggc actcctgtgg
8401 aagttgttag gacttccgct acctaaagat ctacaagata ttgaattgat taatctgaca
8461 actgaagctg attttttgcg acaagaacag acgataaagg ataagttact tgcactccgt
8521 gacttaagca caaaacatct caagcgccat gggctattat ggaaccatat tgaacctgtt
8581 tgccacccgc ggacattatc ctggttactt aaactagaat gttcaaaggc acagcacctg
8641 cgagctaaga gagaacaggt gataaatcaa tcatttaaag agcacggtac aaatatacaa
8701 cacctattca cttcactaag ccacaaatta attagcaata gtggtttatt ttcatctggg
8761 gatcagccac aagaatcacc tcttccagct atctcatctg gtgcaaagac tctgatcaca
8821 tcataccggg cagcagtcaa cacagaatgg agcgaaggta gatggtgttg gctccatgtg
8881 aagcaggtga tgagatactt gatgtatcaa tcgagaattc ataagcattc tacaaatatt
8941 aaagtttgga gtgagaaatc caatataatc ggtgttacac ctgatgtcgt ggttgtaatc
9001 aatgtcctca gaaaaatcta cacagtattg acatttgaga tggtgctaat gtattcggat
9061 actgctgaag gtagagataa tgctattgta gttggacggc tttcaccctt cttgcaattg
9121 gttgtagata aacttggaat attatttgag ttgattgatt cactggcaat tgaaatcgga
9181 gaaaaaattt atgatgtcat tgcgacactt gagagcatgg cgtatgcatc agttcaacta
9241 catgatgcta gcatcgtgca agcaggtgaa tttctttcat ttaatttgag tgagttagta
9301 gagacattga attctttgat agatcctgca caagcgaaac gaattataga aattatcagg
9361 ctatgttaca caggattaag tgtggatcag agcgcagagc tgctgtgttt aatgcgatta
9421 tttggtcacc ctttactgtc agctaaagat gctgccaaga aagtaagaga atcaatgtgc
9481 tcgcctaaag ttgtagagtt tgatactata ttgcagactt tgtctttctt taaagggata
9541 cttatcaacg gttataggag ggcacactca ggaatttggc ctaatattga cccagacaca
9601 atattggatg aagatatcag acaactctac ttagaatctt cagaaatccc acactcaatc
9661 atgttaagga aatatcaggc attgagcttg ttagaattta aaaagagcat tgattttgac
9721 ttgtctgcag atttaagtgc ttatctcaag gataaggcta tttgtaggcc aaagccccaa
9781 tggagtgcaa tatttagaaa atcacttgtc gggaagtcaa gacaaatgaa taattcaact
9841 gacatcagga gcaaccggct cttaatagat ttcctggaat cagatgattt tgatccttat
9901 caggagttca actatgtagt tagtatggat taccttaaag accctgattt ttgcgcatct
9961 tattctctta aagagaaaga aatcaaaaca accggacgaa tttttgcaaa aatgactagg
10021 aaaatgagga gttgtcaagt tttactcgaa tcattgcttt caaaacacat ctgtaaattc
10081 tttaaggaga atggcgtgag catggagcaa ttatcattaa ctaagagtct actatctatg
10141 tctcaactag cgcctaggat ctcaactctc ggattacgcc caattcggaa taatcgtacc
10201 cgaccaaagt atgatgaaaa aaatgaaagt tcagcaaatt tcagtggaga ccctaggggt
10261 gcattagttc gtgacaagac ggttgttgca actttcttaa ccacggactt acaaaaatat
10321 tgtcttaatt ggagatattc gtcaattaaa ttatttgctc aagctctcaa tcaattattt
10381 ggacttgatc atggattcga atggatacac ttacgtttaa tggattctac gatgtttgtg
10441 ggtgatcctt attctccgcc agaatcagcc ctctatactg atttggatga tgctcctaac
10501 gatgatattt tcatagtatc tgcaagggga gggattgaag ggctgtgcca aaaactatgg
10561 actatgattt caattagtat aatccattgc gttgcagaaa agattggagc tagagttgca
10621 gcgatggtcc agggcgataa tcaagtaatt gcaatcactc gagaactgta tagtggagac
10681 tctgctgagt cattactgga tgaattggat catttaagtg atcaatactt tgctgaattc
10741 aaacgacaca actatggtat cggccataac ttgaaactca aggagacaat tcgaagtcat
10801 tcattttttg tctattcaaa acgagtattc tgggaaggac ggatcctcag ccagatactc
10861 aagaatgcta cgaagctctg ttatattgca gatcatgtag gtgaaaactc tgtgtcatcc
10921 tgtagcaact tgtcttctac tattgcccgg ttagtagaaa atggatacga aaaagacact
10981 gcgtttatac ttaaccaatc atacttgatg aaccaactga tgatagacga gcaatacact
11041 ctcacctgtg attatagtga agcaagacgt cttataggaa cagacaatta cagaaatttg
11101 ttttatgcaa cactcatccc tggtcaagtc ggaggctata actttctcaa catcagtaga
11161 ctgtttacaa gaaatattgg tgatccagtg acaagtgcca tctcagatat aaaatggtat
11221 attaaaagta acctgttgcc tcgtcgagta cttaaaaatc tgatactacg tgaacctggc
11281 gatggagggt gggctacttt gtgtgccgat ccttatgcac ttaacattca atatactcaa
11341 ttgccgacaa catacctcaa gaaacataca cagcgaacat tgcttgcatc agcgtctaat
11401 cctctattgt ccggagtgca aataccatca cagcatattg aagaggaatt acttgctcaa
11461 ttcctccttg atcgtgaggc agtaatgcct agagttgcgc acgtgatcat ggaatctagc
11521 attttgggcc gaagaaaaca gatccaagga ttgattgaca ccacccctac aattatcaaa
11581 accgctctaa tgcatcatcc tgtttctcga cggaagacag aaaaaattgt taattactcg
11641 atagattatc taactgcatg tcacgatttc attatagctc aaattgagtt ccctacctca
11701 aaggaggaga tgtgggaaaa taatttcgta gatgaggata cctgtagtgt cattattgcc
11761 gaattcttgc gagctgtcag ctggagaaat ctactcaatg gcagaatcat ccagggcgtg
11821 acatcacctg ataccatcga acttataaca ggatctttaa ttggagaaaa ctcttattgt
11881 cgcttatgtg catcaggaga caacaactat acatggatgt tcttacctgg ccctacgaac
11941 ataaccagcc catatgttag cagttcgaag attagagtac cctatttagg gtctaaaaca
12001 gaggaaagga gaactgcttc gatggctact gttaagggta tgtcccatca cctcaaggct
12061 gcgttaagag gtgcatcagt atatatttgg gcttttggtg acacggagca aaactgggag
12121 gatgctctta aaattgtgag cacaagatgt aacatctcta tcaaccaatt aaaactgctg
12181 actcccacac ctagcagctc caacattcag cacaggcttg cagacggtat tagtgtgcaa
12241 aagtttactc cagcaggatt atcaagagtt tcttcttttg tgcatatttg caatgatgca
12301 caaaaactag agaaggacga tggtcaagta gactccaatt tgatatatca gcagattatg
12361 cttacaggac tcgcagtatt tgagacaatt cacccaatga atatagaatg ggttagttat
12421 aatcagacac tgcatctgca tactggccta tcttgttgca cacgagaagt agaaggtagt
12481 ttagttaacc ctccttctca tgagcttggg gagattacta taactcagca aaataagttc
12541 ctatttgatt cagaacccat ccccgagata gaaaatatca agattgcact taaggaattc
12601 aaagtaatgg agataaatct tgacggccta tcaggatatg attcaattaa attgttgagc
12661 aagtgcacag caagattaat atgtgagtgt ataaatgaag aaggggttag ttcctcagtt
12721 aaaaatgatg cagtgattag cttcgacaat acaatcaatt ggatatcgga gactcttatg
12781 tgtgacattc attacctagt gacatgtatt ggacaagaga tattgactca gctggcttat
12841 caaatatact atctccgaat tcgaggattg aacagcattc ttgcatatat cgaaagcaca
12901 ttagagagaa tacctgtgat tcaactagca aatttcgctc tgactatatc tcatcatgaa
12961 atttggagga ggctggagct gactgggctc aggtgtaatg cacgagttgc atacctagcc
13021 aatgtagatt ttataggcgc aagtcgtgat gtaatcctat acgggtgcag actctacttg
13081 caagggctgt taatccaaga agaaccatcc taccttttct ttgatgtatg tgacggtgat
13141 cttaatgcta aaatggaaca gtttctagca aggcgtttat gcatcattgt ctctcttata
13201 ggtacgacac tcaattaccc tatcataaga caggagtctc ccattcaaaa atgtgtaact
13261 ctgagtgact tcattgaaac gatatctgta tctgatgcca ggtgcgcagc aactgctaga
13321 gtgctccaaa ctgttgcatt gtctccttca atagacacag tccccacgaa cttatattac
13381 acaactcgca gagtcctgtc aaatattagg agcagtgaga tctctagagc acagatcacg
13441 tacctttaca acgaggatat accgacacac tatgatgaat tagggataga tccagtgacc
13501 acagatgatc caattattca gaggggtttg ttcttcaacg tagaattgac tgcagacaag
13561 ttatcaactc atgtcttgcc ttcagtttgt gggctattga atgacacatc tgtcccgctt
13621 aatatggagt atgataaacc gggctttttg ataacacaac ttacaaaaag cgtaggtaca
13681 tctagcacga gctggtataa atttgcagta tggtatgcaa cacgtatgag acaatctgtc
13741 atccttggtg atagcatgta tgttggagag ggaagcggct gtgtgatgac tttattcgag
13801 taccttgacc cgagcaacaa tatattctac aattcgttat tcagtagtga catgaaccca
13861 ccccaaagaa attatgggtt gagtccatat caatttgaga gatcaatagt ttataagaat
13921 attttagcag gggcttcttc aaaatatggc tttacacaag agttccacaa attatggaga
13981 gagatagatg cagaaaccaa catatctgaa ccagccttta tgaattatgc tctagaagta
14041 ataaagccac acagttgtaa gcgaattgtc tgtgatgctg agtttgattc agggatgcct
14101 gaagagcgca taattcaagc atatactcat ataatcctgc tgtcatcata tgcattgaca
14161 aagcatggac tgattttact gaagttgcac tgtacatcag agaggattac acaatttgta
14221 ttctcgtccc tcctaatgat tttcggtcga gtacaaattc atcggaatgg ttacatgaac
14281 ttgaacaacc aggaaatttt agtatctgcg actcttgggg aagttataaa ttatgtttct
14341 attcccccaa tactcactcg cataaaagca ctgtttgatt caggacttac tataatacat
14401 cctgacaatt taaggagaat tagaactcaa gaggagtctc tcagaattaa gctgcagcaa
14461 ttagaaagaa atgtattgtc caaagcagtc aaactccaac tatgcaagac agatatctta
14521 ttacttcatc tcggtggctc acttattcaa cctggccaga tcaatattca ggaactgcga
14581 gagaagtcag ccggggaatt gcagaaggaa atcatagaac taatagacac agcaatatca
14641 gagataaatg taatcaaaaa cgaggcagtg gatttagata tagcgttgat gatgagccct
14701 tataatatta acaaatcaag gaagatagct actatagcta gaatatgcac gagaagagtt
14761 atccctattt ggttgataat gagtatccaa ctaaactcca gctcattggc atctgtctgt
14821 gccgtcttgg agaggggagt aatatcgtgg gaaacatgca tgacatcaag ggaatatata
14881 tcctgttcaa caagacccag atttatcaag aaaattattg gagctagtac agtggagcga
14941 ttattcaaga cctgtctctt atag
//
