LOCUS NC_039016 15180 bp RNA linear VRL 24-AUG-2018
DEFINITION Avian paramyxovirus UPO216 isolate APMV-15/WB/Kr/UPO216/2014,
complete genome.
ACCESSION NC_039016
VERSION NC_039016.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Avian paramyxovirus UPO216
ORGANISM Avian paramyxovirus UPO216
Viruses; Riboviria; Orthornavirae; Negarnaviricota;
Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae;
Avulavirinae; Orthoavulavirus; Orthoavulavirus upoense.
REFERENCE 1 (bases 1 to 15180)
AUTHORS Lee,H.J., Kim,J.Y., Lee,Y.J., Lee,E.K., Song,B.M., Lee,H.S. and
Choi,K.S.
TITLE A Novel Avian Paramyxovirus (Putative Serotype 15) Isolated from
Wild Birds
JOURNAL Front Microbiol 8, 786 (2017)
PUBMED 28529504
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 15180)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (24-AUG-2018) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 15180)
AUTHORS Lee,H.-J., Kim,J.-Y., Lee,Y.-J., Lee,E.-K., Song,B.-M., Lee,H.-S.
and Choi,K.-S.
TITLE Direct Submission
JOURNAL Submitted (25-JAN-2017) Avian Disease Division, Animal and Plant
Quarantine Agency, 177 Hyeokshin 8-ro, Gimcheon-si,
Gyeongsangbuk-do 39660, Republic of Korea
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to KY511044.
##Assembly-Data-START##
Sequencing Technology :: Sanger dideoxy sequencing
##Assembly-Data-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..15180
/organism="Avian paramyxovirus UPO216"
/mol_type="genomic RNA"
/serotype="15"
/isolate="APMV-15/WB/Kr/UPO216/2014"
/host="wild duck"
/db_xref="taxon:2006690"
/country="South Korea"
/collection_date="2014"
misc_feature 1..55
/note="leader"
gene 122..1597
/gene="NP"
/locus_tag="D1U15_gp1"
/db_xref="GeneID:37619974"
CDS 122..1597
/gene="NP"
/locus_tag="D1U15_gp1"
/codon_start=1
/product="nucleoprotein"
/protein_id="YP_009508499.1"
/db_xref="GeneID:37619974"
/translation="MSSVFEEYEQLLASQIKPSGSQGLGDKGGTLRVEIPVFTLNSDD
QEDRWHFAVFCLRVAVSEDANKPLRQGALISLLCAHSQVMRTHVALAGRQTEATMAIL
EIDSFSNGVPQFNNRSGVSDERTQRFMMIAGSLPRACSNGSPFTSSGAEDDVPEDITE
TLERILSIQVQIWVTVAKAMTAYETADESETRRINKYMQQGRVQKRYIMHPVCRSAIQ
MIIRQSLPVRTFLVSELKRGRNTAGGTSTYYNFVGDIDAYIRNTGLTAFFLTLKYGIN
TKTSALALSSLSGDIQKMKQLMRLYRAKGDNAAYMTLLGDSDQMNFAPAEYACLYSFA
MGMASIIDKGTTRYQFARDFMNTSFWRLGVEYAQAQGNSIDESMAAELKLTPAARRGL
AATAQKVSEESGSAEMPMQSAGVLTGISQTADRSDQPKGQSTKVPRDANADDTQFLDL
MRAVAAGMRDASQQNQGEPPSTGPPPPTPGGNQDQDQEWGY"
misc_feature <620..>1357
/gene="NP"
/locus_tag="D1U15_gp1"
/note="Paramyxovirus nucleocapsid protein; Region:
Paramyxo_ncap; pfam00973"
/db_xref="CDD:395775"
gene 1899..3098
/gene="P"
/locus_tag="D1U15_gp2"
/db_xref="GeneID:37619969"
CDS 1899..3098
/gene="P"
/locus_tag="D1U15_gp2"
/codon_start=1
/product="phosphoprotein"
/protein_id="YP_009508500.1"
/db_xref="GeneID:37619969"
/translation="MATFTDEEIDELFETSGTVIENIISAQPNPVETVGRSAIPQGKT
KALSLAWEKYANTPEADKREDTDKGPHASQPVPEVPTTGTPNLDNPSGSELDAGETPV
DPSEGCIRTGASSTLLSMLDKLGTKSPGTKKGSENAALTPGRSQMMYPVATGATQLVP
ALEQKQVTGAMVLNPNGNRDTGGSTASSGPQKGSLLSAGATHHAPRSDPSPGSTPVYA
GSVPLPADFVQLIMTMMETVTQKMNRIDYQLDLIVKQTASIPPLRTEIQQIKTSLAVM
EANLGMMKILDPGNAHISSLSDLRAAARQHPVLLAGPGDPSPYIAQSGEIAVNKLAQP
VSNPTEVVKASQAPVPDLNIEKETVRALIMSRPMHPASSSRLVAKLECATTIEEVRKI
KRLALNG"
misc_feature 1899..2072
/gene="P"
/locus_tag="D1U15_gp2"
/note="N-terminal region of Paramyxovirinae phosphoprotein
(P); Region: Soyouz_module; pfam14313"
/db_xref="CDD:316803"
misc_feature 2628..3089
/gene="P"
/locus_tag="D1U15_gp2"
/note="Paramyxovirus P/V phosphoprotein C-terminal;
Region: Paramyx_P_V_C; pfam03210"
/db_xref="CDD:281237"
gene 3326..4420
/gene="M"
/locus_tag="D1U15_gp3"
/db_xref="GeneID:37619970"
CDS 3326..4420
/gene="M"
/locus_tag="D1U15_gp3"
/codon_start=1
/product="matrix protein"
/protein_id="YP_009508501.1"
/db_xref="GeneID:37619970"
/translation="MDSTRTIGIHFDPTLPASSLLAFPIVLQETGDGKKQITPQYRIQ
KLDSWTESKDDSLFITTYGFIFRVGGGGSNMGTIEGTPTRELLSAAMLCIGSVSNTTD
PVEIARACLSLMITCKKSATNTERMIFSIVQAPQILQSCKVVANKYASVSAVKHVKAP
EKVPGDGTLEYKVNFVSLTVVPKRDVYRIPSTALRVSGPSLYNLALNVIIAVEVDDKS
PLTRSLTRTEEGFCANLFLHIGLMSTVDKKGKKISFDKLERKIRRLDLSVGLSDVLGP
SILIKARGARTRLMSPFFSSSGTACYPIANASPQVAKILWSQSASLRSVKIVIQAGTQ
KAIAVTADHEVMSTKLEKNHTISKFNPFKK"
misc_feature 3356..4378
/gene="M"
/locus_tag="D1U15_gp3"
/note="Viral matrix protein; Region: Matrix; pfam00661"
/db_xref="CDD:395535"
gene 4592..6247
/gene="F"
/locus_tag="D1U15_gp4"
/db_xref="GeneID:37619971"
CDS 4592..6247
/gene="F"
/locus_tag="D1U15_gp4"
/codon_start=1
/product="fusion protein"
/protein_id="YP_009508502.1"
/db_xref="GeneID:37619971"
/translation="MIFTMYHVTVLLLLSLLTLPLGIQLARASIDGRQLAAAGIVVTG
EKAINLYTSSQTGTIVVKLLPNVPQGREACMRDPLTSYNKTLTSLLSPLGEAIRRIHE
STTETAGLVQARLVGAIIGSVALGVATSAQITAAAALIQANKNAENILKLKQSIAATN
EAVHEVTDGLSQLAVAVGKMQDFINTQFNNTAQEIDCIRISQQLGVELNLYLTELTTV
FGPQITSPALSPLSIQALYNLAGGNLDVLLSKIGVGNNQLSALISSGLISGSPILYDS
QTQLLGIQVTLPSVSSLNNMRAIFLETLSVSTDKGFAAALIPKVVTTVGTVTEELDTS
YCIETDIDLFCTRIVTFPMSPGIYACLNGNTSECMYSKTQGALTTPYMSVKGSIVANC
KMTTCRCADPASIISQNYGEAVSLIDSSVCRVITLDGVTLRLSGSFDSTYQKNITIRD
SQVIITGSLDISTELGNVNNSINNALDKIEESNQILESVNVSLTSTNALIVYIICTAL
ALICGITGLILSCYIMYKMRSQQKTLMWLGNNTLDQMRAQTKM"
misc_feature 4682..6091
/gene="F"
/locus_tag="D1U15_gp4"
/note="Fusion glycoprotein F0; Region: Fusion_gly;
pfam00523"
/db_xref="CDD:395418"
gene 6454..8310
/gene="HN"
/locus_tag="D1U15_gp5"
/db_xref="GeneID:37619972"
CDS 6454..8310
/gene="HN"
/locus_tag="D1U15_gp5"
/codon_start=1
/product="hemagglutinin-neuraminidase protein"
/protein_id="YP_009508503.1"
/db_xref="GeneID:37619972"
/translation="MERGISEVALANDRTEEKNTWRLIFRITVLVVSVITLGLTAASL
VYSMNAAQPADFDGIIPAVQQVGTSLTNSIGGMQDVLDRTYKQVALESPLTLLNMEST
IMNAITSLSYKINNGGNSSGCGAPIHDPEYIGGIGKELLIDDNVDVTSFYPSAFKEHL
NFIPAPTTGAGCTRIPSFDLSATHYCYTHNVILSGCQDHSHSHQYIALGVLKLSDTGN
VFFSTLRSINLDDTANRKSCSISATPLGCDILCSKVTETELEDYKSEEPTPMVHGRLS
FDGTYSEKDLDVNNLFSDWTANYPSVGGGSYIGNRVWYAVYGGLKPGSNTDQSQRDKY
VIYKRYNNTCPDPEDYQINKAKSSYTPSYFGSKRVQQAILSIAVSPTLGSDPVLTPLS
NDVVLMGAEGRVMHIGGYTYLYQRGTSYYSPALLYPLNIQDKSATASSPYKFDAFTRP
GSVPCQADARCPQSCVTGVYTDPYPLIFAKDHSIRGVYGMMLNDVTARLNPIAAVFSN
ISRSQITRVSSSSTKAAYTTSTCFKVIKTNRIYCMSIAEISNTLFGEFRIVPLLVEIL
SNGGNTARSAGGTPVKESPKGWSDAIAEPLFCTPTNVTRYNADIRRYAYSWP"
misc_feature 6931..8145
/gene="HN"
/locus_tag="D1U15_gp5"
/note="Hemagglutinin-neuraminidase (HN) of parainfluenza
virus 5, Newcastle disease virus, and related
paramyxoviridiae; Region: HN; cd15469"
/db_xref="CDD:271233"
misc_feature order(6943..6960,7030..7032,7066..7068,7093..7095,
7099..7101,7135..7137,7141..7143,8101..8112,8122..8124,
8128..8136)
/gene="HN"
/locus_tag="D1U15_gp5"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:271233"
misc_feature 6970..7146
/gene="HN"
/locus_tag="D1U15_gp5"
/note="Sialidase propeller 1 [structural motif]; Region:
Sialidase propeller 1"
/db_xref="CDD:271233"
misc_feature order(6973..6975,7225..7227,7348..7350,7402..7404,
7540..7545,7654..7656,7699..7701,7705..7707,7849..7851,
7945..7947,8029..8031)
/gene="HN"
/locus_tag="D1U15_gp5"
/note="receptor binding site [chemical binding]; other
site"
/db_xref="CDD:271233"
misc_feature 7153..7311
/gene="HN"
/locus_tag="D1U15_gp5"
/note="Sialidase propeller 2 [structural motif]; Region:
Sialidase propeller 2"
/db_xref="CDD:271233"
misc_feature 7336..7641
/gene="HN"
/locus_tag="D1U15_gp5"
/note="Sialidase propeller 3 [structural motif]; Region:
Sialidase propeller 3"
/db_xref="CDD:271233"
misc_feature 7645..7788
/gene="HN"
/locus_tag="D1U15_gp5"
/note="Sialidase propeller 4 [structural motif]; Region:
Sialidase propeller 4"
/db_xref="CDD:271233"
misc_feature 7855..8004
/gene="HN"
/locus_tag="D1U15_gp5"
/note="Sialidase propeller 5 [structural motif]; Region:
Sialidase propeller 5"
/db_xref="CDD:271233"
misc_feature 8023..8145
/gene="HN"
/locus_tag="D1U15_gp5"
/note="Sialidase propeller 6 [structural motif]; Region:
Sialidase propeller 6"
/db_xref="CDD:271233"
gene 8411..15019
/gene="L"
/locus_tag="D1U15_gp6"
/db_xref="GeneID:37619973"
CDS 8411..15019
/gene="L"
/locus_tag="D1U15_gp6"
/codon_start=1
/product="large polymerase protein"
/protein_id="YP_009508504.1"
/db_xref="GeneID:37619973"
/translation="MAEPTGVRAEHQIILPESHLSSPLVKHKLLYYWKLTGLPLPEEC
EFDPLILGRQWRKILETGAPDTERMVKLGRLAHQNLNHNKPIRGLLHPRTLTMLTTIE
IPDSSKKFRTIEKKIQIHNKVFGGLFNTLCDQVEQKLLGRHSKQIISRSPEYLRLRED
PAFWFHSAWSSAKFAWLHIKQLQRHLTVCARSRMGPGNPITLIHNHGQVFVTPELVII
TENSSNQFTCLTQEMVLSYSDMLEGRDMVSFVSSTATHLLPLKDKIQSLLLLIDALAM
DMGNNVYEVISLMEGLAYGAVQLLEPSELFAGNFLSFNLHELKDILLPHFRIDIVQRI
ITIVSEVFSGLDQTQSAEMLCMLRLWGHPLLESRAAASAVRKQMCAPKLLDFDTVLQV
LSFFKGTIINGYRKKNAGVWPRVKQSTVYGSTITQLHADSAEISHEIMLKEYKNLSAL
EFEQCIDFDPVSNLSMFLKDKAIAHPKHNWLASFRKNLLSDTQKKEVRDATSTNRLLI
EFLESEDFDPYEEMKYLTTLEYLRDKNVAVSYSLKEKEVKVNGRIFAKLTKRLRNCQV
MAEGILADQIAPFFQGNGVIQDSISLTKSMLAMSQLSFNSNKKRIVDRKEGVSKDRHR
DGINRHRRRVATFITTDLQKYCLNWRYQTIKLFAHAINQLMGLPHFFEWIHLRLMDTT
MFVGDPFNPPSNPSDINLDDAQNDDIFIVSARGGIEGLCQKLWTMISISAIQLAAARA
HCRVACMVQGDNQVIAVTKEVDASDPPETVLQQLHEASNSFFNELMAVNHNIGHNLKD
RETLRSDTFFIYSKRIFKDGTILGQALKNASKLVLISGDLSENTVMSCSNISSTIARL
CENGLPKDFCYYLNYLMSCIQTYFDKEFSIFPYNEARRLDQNKEDIKFVHTYVLTPAQ
VGGLSNLQYSRLYTRNIGDPGTTAFAELKRLETAKLIPKQVIINILTRPPGNGDWASL
CNDPYSFNFETVSSPNIVLKKHTQRVLFETCSNPLLSGVHTEDNEAEEKMLAEFLLNQ
ESIHPRVAHAIMEASSVGRRKQIQGLVDTTNTVIKIALSRRPLGYKRLSRIINYSRMH
EELFKEEVFSAARRGSPLVNSEMCSLALADYARQRSWSILTGGRQILGVSNPDTIELV
EGEVLSLSGGCRLCDSGDEQFTWFHLPRNICLTDDTNSNPPMRVPYLGSKTQERRAAS
LAKIAHMSPHVKAALRASSVLIWAYGDNETNWSAALKIARSRCNISSEYLRLLSPLPT
AGNLQHRLDDGITQMTFTPASLYRVSPYVHISNDSQRLFTEEGVKEGNVVYQQIMLLG
LSLLESLFPLTTTRIFDEVTLHLHSKFSCCIREAPVSVPFELQGYLPDLRTVASNKFM
FDPQPITDTDFGRLNLTIFRSYELNLDSYPTIELMNVLAIASGKLIGQSVVSYDEDTS
IKNDAILVYDNTRNWISEAQNCDVVKLFEYAALEILLDCAYQLYYLRVRGLDNMVLYM
SSLLKNMPGILLSNIAATISHPVIHSRLHSVGLINHDGAHQLASVDFVETSARLLTTC
IRRIVTGLHSGNKYDLLFPSVLDDNLTEKMLQLISRLCCVLVLLYSTTKAIPKIRGLS
AEEKCATLTSYLLSDAVRPTMSSAQIDSLLSPNIVTFPANLYYMSRKSLNLIREREDR
DTVLALIFPPDVIMEAPDIRSLGSRTDDPMTKSPAAFIKELAINAPARYDTCFPSQLT
QMEGTQSRPDEMLIRYLFRGIGTASSSWYKAAHLLSIPEVRLARHGNSLFLAEGSGAI
MSLLELHVPHEVIFYNTLFSNEQNPPQRHFGPTPTQFLNSVVYKNLQANVPCKDGFVQ
EYVPLWRENADESDLSSDKSVSYITSTVPFKSVSLMHCDIEVPMGSNQSYLDQVATNL
ALIAMHTIRDKGVFIVKVLFSMGYYFHLLINLFFPCSTKCYVVSNGYACRGDLECYLI
FVMGYTGGSTFVREVVRMAKDLVRRNGTLLHSKDERTLMEVFNAQFMRVQELTSLPTP
GLIRILQKNIDGALIEAGGQPVRPLCRENLSPACFDATKATDIIASHIDTAIRSVIYI
EEGGALADTVFLFTPYNLSVEGKKLTSLTQCTRQIFDMILLSITKEDQIKISEMMGIV
LKGTVCLEDLIPLRMYLKRSTCPKYLKEVLGMQKLRELFKTTSRFVLSRSTQKYYMKI
IGNAIKGYYSMI"
misc_feature 8459..11686
/gene="L"
/locus_tag="D1U15_gp6"
/note="Mononegavirales RNA dependent RNA polymerase;
Region: Mononeg_RNA_pol; pfam00946"
/db_xref="CDD:395756"
misc_feature 12050..15001
/gene="L"
/locus_tag="D1U15_gp6"
/note="mRNA capping enzyme, paramyxovirus family; Region:
paramyx_RNAcap; TIGR04198"
/db_xref="CDD:275046"
misc_feature 15134..15180
/note="trailer"
ORIGIN
1 accaaacaga gaatctgtaa ggtacggtaa gagacgaaca agcaattgaa atcacacggg
61 tagaaggagt gaaatccgac tacgacatcg aacagcccgg tcgatcacta cctctgccaa
121 catgtctagc gtattcgagg agtacgagca attgcttgca tcacaaatca agcctagcgg
181 gagccaaggt ctaggggaca aggggggcac ccttcgggtt gagataccag tcttcacttt
241 gaatagtgat gaccaggaag acagatggca tttcgcagtt ttctgcctca gagtggcagt
301 tagtgaggat gctaataaac ctctgcgtca aggggcgctc atctctcttc tttgtgcaca
361 ctctcaggtg atgaggaccc atgttgccct agctggacga cagacagagg ctacaatggc
421 gatactagag atagactcgt tttccaatgg tgtcccacag ttcaacaaca gaagcggtgt
481 gtcagatgag agaactcagc ggttcatgat gattgcaggt tctctacctc gtgcctgcag
541 caatgggtca ccttttacct catcaggggc agaagatgat gttcccgagg atattacaga
601 gacgcttgaa aggatcctgt ccattcaagt gcagatctgg gtaacagtcg ccaaggccat
661 gacagcatat gagacagcag atgagtctga gaccaggaga atcaacaaat acatgcagca
721 agggagagta cagaagaggt atataatgca ccccgtatgt aggagtgcaa ttcagatgat
781 aattaggcaa tcccttccag tcagaacatt cttggtgagc gaactcaaac gaggacgcaa
841 tacggcaggt gggacttcaa cctactataa ctttgttggt gacattgatg cgtatatcag
901 gaatacaggg ctgactgcct tcttcctgac cctgaagtac ggtatcaata caaagacttc
961 agccctggca ctgagcagct tgtctggcga tattcagaag atgaagcagc ttatgagact
1021 ttatcgtgcc aagggtgaca atgcagcgta catgactctg ctaggtgaca gtgaccagat
1081 gaactttgct ccagctgagt atgcatgcct gtattcgttt gctatgggga tggcatcaat
1141 catagacaaa ggaaccacaa gatatcaatt tgcaagagat ttcatgaaca catcattctg
1201 gcggttgggt gtagaatatg cacaagccca agggaacagc attgatgaga gtatggcagc
1261 tgagcttaaa ttgactccag cagccagaag agggctagcg gccacagcac agaaggtgtc
1321 agaggaatcc gggagcgcag agatgcccat gcagtctgcg ggagtgctga ctgggatctc
1381 ccaaacggcc gacagatctg atcagcccaa aggccagtcc actaaggtgc cgagggatgc
1441 aaacgctgac gacacccaat tccttgatct gatgagagca gtagcagcag ggatgcgaga
1501 tgcctcacag caaaaccagg gcgagccacc cagcacgggc ccccctcctc ccaccccagg
1561 aggcaaccaa gaccaggatc aggaatgggg gtactaatca gagactcctg agcttaacct
1621 gacaggacac ccgccagaca atccccgaca tccccacccc agatgcagcc gctccatttc
1681 ccaaaccaaa tctcccacac atgaacccca tgaacaacca aaaaatcacc aaccagccgc
1741 cccaacaacg caaccacagc gccaaagaca ttgcttgcag cacaatcagc cgtcctacat
1801 tgattagaaa aaactacggg tagaagagtc aaccacccaa actcacccgg tgcccccctc
1861 catctcacga ccgagaactc cagacccaga aaccaaaaat ggccacattc acggacgagg
1921 agatcgatga gctcttcgag acaagcggca ctgtaataga gaacatcatc agtgctcagc
1981 ctaacccggt tgaaaccgtc gggaggagcg ccatccccca agggaaaacc aaagctctaa
2041 gcctggcctg ggaaaaatac gccaacacac ctgaagctga taaacgggag gacacagaca
2101 aaggcccaca cgcaagccaa ccagtcccag aggtcccaac cacaggcact ccaaacctgg
2161 acaaccccag tggatctgag ctcgatgcag gggagacgcc tgtcgaccca tcagaagggt
2221 gcatacggac aggtgcgagc tccactctcc tgtccatgct agacaagctt gggaccaagt
2281 cccctggaac taaaaaaggg tcagagaatg ctgccctgac accagggagg agtcagatga
2341 tgtatcctgt ggcaaccgga gccacgcagc tggttccagc tctggagcag aagcaagtga
2401 ccggagcaat ggttctgaac cccaatggaa accgggacac cggagggagc acagcatctt
2461 ctggacccca gaagggatca cttctctcag ctggtgcaac ccatcatgct ccccgatcag
2521 acccgagccc gggcagtact cctgtatatg cgggaagtgt cccgctacct gccgactttg
2581 tacaactgat catgactatg atggagacag tgacccagaa gatgaatcgg attgattatc
2641 aattagatct aattgttaag caaacagcat cgataccccc cttacgaact gaaatacagc
2701 agattaaaac ttcccttgca gtgatggagg ctaacttggg aatgatgaag atattagacc
2761 cagggaatgc gcatatatca tctttaagtg atctccgtgc agcagctcgc caacatccag
2821 tgttgcttgc tgggccagga gatccatcac cctacattgc acagtcaggt gaaatagctg
2881 tgaataagct cgcccaacca gtatctaatc cgacagaagt agtgaaggct agtcaggcgc
2941 cagtcccgga tctcaacata gagaaagaga ctgttcgcgc gctgatcatg tcgagaccca
3001 tgcaccctgc aagttcaagt aggctggttg ctaaactcga gtgtgcgact accattgaag
3061 aggtaagaaa gattaaacgc cttgctttga atggttaaca tataaaacac tgtcttattc
3121 aattaaatca gcaagagggc cattatagct aaccatgatc tgaatgtgat tcttgatcca
3181 tgtgatcctg tattgaatgc cagcatataa ttagtaagta agctgctact agacctcaga
3241 tcttaccaat gagatcatct ttgatcacaa acataggtat taagaaaaaa tacgggtaga
3301 agatcttatt gcatgtatcg caataatgga ctctacccgt accattggta tacattttga
3361 tcccaccctc cctgcgagta gcctattggc attccctatc gtgctacaag aaacaggaga
3421 tggaaagaaa cagatcaccc cgcaatatcg gatccaaaaa ttggattcct ggacagaatc
3481 aaaagatgac tctctgttca tcacaaccta tggttttata ttcagggttg gtggtggagg
3541 aagtaatatg ggaacaatcg aaggtacgcc caccagggaa ctgctgtccg ctgccatgct
3601 atgtattggt agtgtctcaa acacaactga tccagtagag atagcaaggg catgtctctc
3661 tctgatgatc acgtgcaaga agagtgcaac caacaccgag agaatgatat tctctattgt
3721 tcaagcccca cagatactcc aaagctgcaa agtggttgcc aataagtatg catccgtgag
3781 cgctgtgaaa catgtcaaag cacctgagaa agtacctggt gacggcacac tagagtacaa
3841 agtcaacttt gtgtcactaa ctgtggtacc caagcgtgat gtgtatcgta taccaagcac
3901 cgcactgagg gtatctgggc caagcttgta caatctggct ctcaatgtca tcattgcagt
3961 cgaggttgat gataagagcc ctttgactcg gtccttgact aggactgaag agggtttctg
4021 tgcaaacttg tttctacaca taggtctcat gtctacagtt gacaagaagg ggaagaaaat
4081 atcatttgac aagctggagc gcaagatcag aaggctggat ttatctgtcg ggttgagtga
4141 tgttctcggc ccttcaatcc tgatcaaagc aaggggtgct cgtacccgct tgatgtctcc
4201 tttcttctca agcagcggga ctgcgtgcta tcccattgcc aatgcatcgc cccaggttgc
4261 taagatctta tggagccaga gtgcaagctt gaggagtgtc aagattgtca tccaggcggg
4321 aactcaaaag gccattgccg tgactgcaga tcatgaggtg atgtcaacaa agctggagaa
4381 aaatcacacc atctcaaaat tcaatccttt taagaaataa attgataata ctatggccaa
4441 tcacacaatg atgatcacct caattataat tcgtcctaat taaatcaacc acaattgtgt
4501 caagtagtat tagcttgagc atttacaaaa aaaccatgca cggggagaac aacagatctc
4561 tgccctcctt tgataatcca agatctctgc aatgatattc accatgtatc acgtaactgt
4621 cctcttgcta ctatcgttgc ttaccctgcc actaggcatt caattagcta gagccagtat
4681 agacggcaga cagctggctg cagccgggat tgttgtaaca ggtgagaaag caatcaacct
4741 atacacatca tcgcagacag gcactatagt agttaaatta ctcccaaacg tacctcaagg
4801 gagagaagcc tgtatgagag atccacttac ttcttataac aagacactga catcacttct
4861 atcacccctt ggtgaagcaa tcaggcggat acacgagtca acgaccgaaa cagcaggatt
4921 agttcaggcg agactagtgg gtgctattat tgggagcgtt gctctcggtg tcgctacctc
4981 tgcccaaatc acagctgcag ctgcattgat tcaagccaat aaaaatgccg aaaatatatt
5041 gaagctcaag cagagtattg cagcgacaaa tgaggctgtg catgaagtga ctgatgggct
5101 atcacaatta gctgtggctg tcgggaagat gcaagacttt atcaacaccc agttcaataa
5161 cacggcacaa gaaattgact gtattagaat tagccaacaa ttaggtgtag aacttaatct
5221 gtacttgaca gaactaacta cggtatttgg gcctcagatc acatctccgg ctcttagtcc
5281 actcagtatt caagcactat ataatcttgc aggagggaat ttggatgtgt tgctttcaaa
5341 gattggtgtg gggaataatc aactcagtgc actcatcagc agcggcctga tctcaggcag
5401 cccgatcttg tatgattccc agactcagtt gcttggaatc caagttacgc taccatcggt
5461 gagtagccta aataacatga gagcgatttt ccttgagacg ctgtcagtta gtactgacaa
5521 aggattcgct gctgctctga ttcccaaagt tgttacaaca gtggggacag tcactgaaga
5581 gcttgataca tcttattgca ttgaaacaga tattgatctc ttttgcacca ggatagttac
5641 cttccctatg tctccaggta tatatgcatg cctcaatggg aacacttctg agtgcatgta
5701 ttctaaaact cagggggccc taaccacacc ctatatgagt gtgaagggtt ctatagtggc
5761 gaattgtaag atgacaacct gtagatgtgc agatcctgct tcgataattt cacagaacta
5821 tggagaggcc gtatctttga ttgatagctc tgtgtgcaga gtcatcactt tagatggtgt
5881 aacattgagg ctgagtgggt cctttgactc tacttaccaa aagaatatca caattcgaga
5941 tagccaggta ataataacag ggagtctgga tatatcaact gaattaggca atgttaataa
6001 ctctatcaat aatgcacttg ataagattga agagagtaat cagatacttg agagtgtcaa
6061 tgtatctcta accagcacta atgctttgat tgtatatatt atctgcacag ctttggcatt
6121 gatttgtggg attacaggtt taatactaag ctgttacata atgtataaga tgcgatccca
6181 acaaaagacc ctaatgtggt taggaaacaa taccttagat caaatgaggg cccagacgaa
6241 aatgtagtgg attcatacac tgtcttggga agctactctg atgctcttgt ttgcactaca
6301 atcacatgtc ataaagatca acactaatag caataaattt gtagagaagc tattagaaaa
6361 aaacggggag aactgtcagt acctctactg gatactgtca tctttcgttc tcctgtgaca
6421 ggtagtagta acacacatcg tgcagcttac agtatggagc gagggatcag tgaagttgca
6481 cttgcgaatg accgaactga agagaagaat acatggagac tcatcttccg gataacagtc
6541 ctggtggtca gtgtaataac acttggtctt actgctgcat cactagtcta tagcatgaat
6601 gcagcccaac cagcagattt tgatggtatt atacctgcgg tccaacaggt agggacttca
6661 cttactaata gcataggggg aatgcaagat gtcttggatc gcacctacaa acaggttgca
6721 ttggaaagcc cactgacact gcttaacatg gagtcaacta ttatgaatgc catcacatca
6781 ctctcttata aaatcaataa cggtgggaac tccagtggtt gtggtgcgcc aattcatgat
6841 cctgaataca tcggtgggat aggtaaggag ctactaattg atgataatgt agacgtaaca
6901 agtttctatc cttccgcttt caaagaacac cttaacttca ttccggcccc gactactggt
6961 gcaggctgta ctcggatccc atcatttgac ctcagtgcaa ctcattattg ttacactcac
7021 aatgtcatcc tgtcagggtg tcaagaccac tctcactcac accaatatat tgctcttggt
7081 gtcctcaaat tatcagatac aggcaatgtg ttcttctcga ccttgcgttc catcaaccta
7141 gacgacactg caaaccgcaa gtcttgcagc attagcgcaa caccattagg ctgtgatata
7201 ctatgctcta aagttaccga gaccgagctc gaagactaca agtcagagga accaactcct
7261 atggttcacg ggcggttaag ttttgacggc acatatagtg agaaagacct ggatgttaac
7321 aatttgttct ctgactggac agccaactac ccaagtgttg gaggaggtag ctatattgga
7381 aatagggtct ggtatgcggt atacggaggc ctgaagcccg gaagtaatac tgatcagagt
7441 cagagagata agtatgtcat atataaaagg tacaataata cctgcccgga ccctgaggat
7501 tatcagatca ataaggccaa atcttcgtat accccaagtt actttggcag caaaagagtt
7561 caacaggcga tattgtcaat tgctgtctcc cccacactgg gaagtgaccc ggtcttgact
7621 cctctgtcaa atgatgtagt cttgatggga gcagaaggga gagtcatgca cattggaggt
7681 tatacttatc tttatcaaag gggcacgtca tattattctc cagctctctt atacccgctg
7741 aatatacagg acaagagtgc aacagcgtca tctccttaca aattcgacgc tttcacacgc
7801 ccagggtctg tcccctgcca ggcggacgcg aggtgtccac aatcttgtgt tacaggagta
7861 tatacggacc cttacccttt gatttttgca aaagatcact ctatcagagg agtatatgga
7921 atgatgctta atgacgtgac cgccaggctc aatcccattg cagcagtatt tagcaacatc
7981 agcaggagcc agattactcg ggtgagctca agtagtacca aggctgcata tacaacatca
8041 acctgcttta aagtcataaa gactaatagg atatactgta tgagcattgc tgagatcagt
8101 aacaccctgt tcggtgaatt cagaattgtc cctctattgg tagaaatctt atcaaatggg
8161 ggtaacactg ctaggtccgc aggtggcact cctgtaaaag aaagccccaa gggatggagt
8221 gatgccatcg cagaacccct gttctgtacc ccgactaacg taaccagata caatgcagat
8281 atccgtcgtt atgcatacag ctggccataa agcctgacta cctctgtgag agataaaatg
8341 agacaagaga acgccaagtt gattcaacaa tccaattaga aaaaacaaaa aataaaatca
8401 cggggagaaa atggcagagc cgacaggtgt gagagctgaa caccagatca tcttaccaga
8461 atctcatttg tcctccccct tggttaaaca taaactttta tattattgga agttgacagg
8521 tttgccactt cctgaagaat gtgaattcga tccactgatc ctaggcaggc aatggaggaa
8581 gatattggaa accggagcgc ctgacacaga gcggatggtg aagctcgggc gactagccca
8641 ccagaatttg aatcacaaca aaccaatcag aggactactc catccaagaa cgctaacaat
8701 gcttactacc attgagatcc ctgactcaag caagaaattt aggacaattg aaaagaaaat
8761 acagatacat aataaagtgt tcggggggtt gtttaatacc ttatgtgatc aagtggaaca
8821 aaagctactc ggaagacaca gtaagcagat tataagtagg tcaccagagt acctgcgact
8881 aagagaagat cctgcatttt ggtttcattc tgcctggtcc agcgcaaaat ttgcatggct
8941 tcatattaaa cagctccagc gacatttgac tgtttgcgct aggtctcgga tgggccctgg
9001 caatcctatc acattaattc acaatcatgg ccaagttttc gtaacccctg aactcgtaat
9061 tattacagag aattcttcta atcagttcac atgtttgacc caagagatgg ttctttcata
9121 ctctgatatg ctggagggca gagatatggt gagttttgtg tcatctactg caacacacct
9181 gctgcccttg aaggataaga tccagtcact attgctctta attgatgcat tagcaatgga
9241 tatggggaat aatgtgtatg aagtgatttc cttaatggag ggattggcct acggggctgt
9301 ccaacttctt gagccatccg aactctttgc cgggaatttt ttgagcttta acctgcatga
9361 gcttaaagac atcttgttgc cacactttag aattgatata gtacaacgta taataaccat
9421 cgtaagtgaa gtctttagtg gcctagacca gacccaatca gctgagatgc tctgtatgtt
9481 gcgcctctgg ggccacccgt tactagaatc acgtgctgca gcatcagcag tcaggaagca
9541 gatgtgtgct cctaagcttt tggatttcga tacagtgctt caggtgttat ccttctttaa
9601 gggcaccatc atcaatggct atagaaagaa gaatgctggg gtatggccaa gagttaaaca
9661 gtcaactgtg tatggatcaa ccatcactca gctccatgcg gactccgctg aaatctctca
9721 tgaaatcatg ctaaaagagt acaaaaatct gtcagcatta gagttcgagc aatgcataga
9781 cttcgaccca gtctcaaatc tgagcatgtt tttaaaggat aaggccattg cacacccgaa
9841 gcataactgg ctagcatcat ttaggaagaa cctgctgtca gatacacaaa agaaggaggt
9901 cagggatgca acatcaacca accgattact gattgaattt ttggaatctg aggattttga
9961 tccttatgaa gaaatgaagt atttgactac tttagagtat ctcagagaca agaacgtagc
10021 agtatcttac tcattaaagg agaaagaagt aaaagtgaac ggtagaatct ttgcaaagct
10081 gacaaagcga cttagaaact gtcaagtcat ggcagaaggg atccttgcag atcagattgc
10141 gccattcttt caaggtaatg gagtaatcca agacagcatc tctttgacaa agagcatgct
10201 agcaatgagc cagttatcat tcaacagcaa taaaaagaga attgtggacc ggaaagaagg
10261 agttagtaaa gatcgacata gagatggaat taacagacat aggcgcagag tggccacctt
10321 catcactacg gatttgcaaa aatactgttt gaactggaga taccaaacca ttaaactctt
10381 tgctcatgcc attaatcagt tgatggggtt acctcacttc ttcgaatgga ttcatctcag
10441 attaatggat acaacaatgt ttgtggggga cccttttaat ccgcccagca acccatctga
10501 cataaacctg gatgatgcgc agaacgatga catattcatt gtaagtgcac gtggagggat
10561 agaaggatta tgccagaagc tgtggacaat gatttccata tctgctatcc agcttgctgc
10621 tgcaagagca cattgtagag tcgcatgcat ggtacaaggg gacaaccagg ttattgcagt
10681 gactaaagaa gtggatgcga gtgatccacc agagacagtc cttcagcaat tacatgaggc
10741 aagcaatagc tttttcaatg aattaatggc agtgaatcat aatatcggac acaatttaaa
10801 agacagagaa actttaagat ctgatacttt tttcatctat agtaagcgga ttttcaaaga
10861 cggaactatt ctaggccagg ctctgaagaa cgcctctaaa ttagtcctga tctctggcga
10921 cctgagtgaa aacacggtca tgtcatgttc caacatttcc tcaaccattg cgagattatg
10981 tgagaacggt ctaccgaagg acttttgtta ctacctcaat tatttgatgt cctgtataca
11041 gacatatttt gataaagaat tctctatatt cccatataac gaagctcgca gacttgatca
11101 aaacaaagag gacattaaat ttgtgcatac atatgtactg acacctgcac aagttggagg
11161 attgagtaac ctccagtatt cacgattata tacaagaaac ataggagacc ctggaactac
11221 tgcatttgca gaacttaaga gactagagac cgcaaaattg ataccgaaac aggtgattat
11281 aaacattctt actcgccctc caggcaatgg agattgggcc agcttatgta atgacccata
11341 ctcattcaac tttgagacag tatcaagccc gaatatagta ctgaagaagc atactcaacg
11401 cgtattgttt gagacctgct ctaatccatt attgtcaggc gtacacaccg aggacaatga
11461 agctgaagag aagatgttgg ctgaattcct gttaaatcaa gagtccatac atcccagagt
11521 agctcatgcg attatggagg caagctctgt cgggagaaga aaacagatac aaggcttagt
11581 tgacaccacg aatactgtga tcaagatcgc acttagtaga agaccactag gttacaaaag
11641 actcagcaga attatcaact actcacggat gcacgaggag ttgtttaagg aagaagtctt
11701 ctcagctgca agaagaggaa gcccactagt taattctgaa atgtgctcgc tggcgttagc
11761 agactatgca cgtcaacgga gttggtctat acttacagga gggaggcaaa ttctcggcgt
11821 ttcgaatcct gatactatcg aattagtaga aggagaagtg ttgagtttaa gtggagggtg
11881 tagattgtgc gactcaggag atgagcagtt cacctggttt catctcccta gaaatatttg
11941 cctcactgac gatacaaaca gtaatccccc tatgagggtc ccatacttag ggtcgaagac
12001 acaggagaga cgagctgcat ctctggcaaa aatcgcacat atgtcccctc atgtgaaagc
12061 agcccttcga gcttcatcag tacttatttg ggcatacgga gacaatgaga caaactggag
12121 tgctgcacta aaaattgccc gatcccggtg taatatatct tcagaatact tgagattgtt
12181 gtcaccgctc ccaacagcag gaaacctcca acatcgtctt gatgatggta tcacacagat
12241 gacatttacc cccgcatcat tatatagggt ttctccctat gtgcatattt caaatgactc
12301 gcaaagactg tttacagaag agggagtaaa agaaggaaac gtggtatacc agcaaataat
12361 gctattaggt ttatcacttc tggagtcgct tttcccactg accacgacac gaattttcga
12421 tgaggtgact cttcatctac acagcaaatt cagttgctgt attagggaag caccagtatc
12481 ggtacccttt gaactgcaag gatatttacc agatcttaga acggttgcgt caaacaaatt
12541 catgtttgac ccccaaccga tcactgacac tgactttggg cgccttaatc ttaccatatt
12601 taggagttat gagcttaact tagactctta ccccacgatt gaactgatga atgtgctggc
12661 tattgcaagc gggaaactca ttggacagtc agttgtttca tatgatgagg acacctcaat
12721 caagaatgat gcaattttag tgtatgacaa taccaggaat tggataagtg aggcacagaa
12781 ttgtgatgtt gtaaaactgt ttgaatatgc tgcgttggaa attttgctag actgcgcata
12841 ccagttgtat tatctacgag tcagaggttt agataacatg gtcctttata tgagcagctt
12901 gcttaaaaat atgccaggga ttctgctttc aaacatagca gcaaccatat ctcatcctgt
12961 catccactcg cgacttcact ctgttggtct gatcaatcat gatggtgcac atcaactggc
13021 gagtgtggat tttgttgaga catcagcaag attattgaca acatgtatca gaagaatcgt
13081 gactggactg cactcaggga acaaatatga tttgctattc ccatctgtct tggacgacaa
13141 tttgactgaa aagatgttac aattgatatc tcggctatgc tgtgtattag tgctacttta
13201 ttccacaaca aaagccatcc cgaagatcag gggattgagt gcagaagaaa aatgtgctac
13261 actgacaagt tatcttctgt ctgatgctgt gcgtcctacg atgagtagtg cccaaattga
13321 ctctctcttg tctcccaata ttgttacatt tcctgccaac ctttattaca tgtctagaaa
13381 aagtttaaac ctgattcgag aaagagagga tagagatact gtgttggccc tcatcttccc
13441 cccggatgtc atcatggagg ctccagacat tcggtcccta gggtccagga ctgatgaccc
13501 catgaccaag agccctgcag ccttcattaa agaactagct atcaatgccc cagctcgata
13561 tgacacctgt ttcccaagcc agctaaccca aatggaaggc acacagagta gaccagatga
13621 gatgctaata agatacttat tccggggaat cggtactgca tcatcatcat ggtataaggc
13681 agctcatcta ctttcaatac ctgaggtaag gctagccaga cacggaaatt ccttgttcct
13741 tgcagaaggc agtggggcga taatgagcct gctagagttg catgtgccgc atgaagtgat
13801 attctataat acccttttct caaatgaaca gaacccgcct caaagacact ttggacccac
13861 tccaacacaa tttttgaatt ctgtcgtata taagaattta caggcaaatg tgccttgcaa
13921 ggacggtttc gtacaggagt atgtcccgct atggagagag aatgcagatg agagtgactt
13981 gtcatcagat aaatcagtta gttacatcac ctccacagtg ccgtttaaga gtgtaagtct
14041 catgcattgt gacatcgagg tgccgatggg atccaatcag agctatcttg accaagttgc
14101 aacaaatttg gctctcattg ccatgcacac tatcagagat aaaggagtat ttattgtcaa
14161 ggtcctattt tctatggggt actatttcca tctacttatc aacttattct ttccatgttc
14221 tacaaaatgc tacgtggtct cgaatgggta tgcatgtcgt ggggatctag agtgctatct
14281 aatatttgtg atggggtaca caggaggatc gacctttgtg agagaggtgg tgaggatggc
14341 gaaggacctt gtccgcagga atggcacact gctgcacagc aaagatgagc gaacattgat
14401 ggaagtgttc aacgctcaat ttatgcgagt acaagagttg actagtctac ccaccccagg
14461 gcttattaga atactacaaa agaatataga tggtgcttta atagaggcag gtggccagcc
14521 cgtgaggcct ttgtgtcgtg agaatttatc acccgcatgc tttgacgcca ctaaagctac
14581 tgacatcatt gcaagccaca tagatactgc cattagatct gtgatctata tcgaagaagg
14641 cggtgcacta gcagacacag ttttcctttt caccccttat aatctctcag tggagggaaa
14701 gaagctgaca tctctcacac agtgcacaag gcagatattt gatatgatat tactatctat
14761 tacaaaagaa gaccaaatta aaattagtga gatgatgggt atagtcctca agggaacagt
14821 atgcctggaa gatttgatac cacttcgaat gtatctcaaa aggagcacct gcccaaaata
14881 tcttaaggag gtgctgggca tgcaaaagct gagagaatta tttaagacta cctctcggtt
14941 tgtactaagt agatcaactc agaagtatta tatgaagatt atcgggaatg caatcaaagg
15001 atactattcc atgatataat ataccagcag atggtaagag aaataataaa tttttatttt
15061 tttcttttgg ggtcataata atacaattat cgctttctga atcgattcag cacaaatcag
15121 aattaagaaa aaattagcac attcattgat attactcatt tcaccaaatc tttgtttggt
//
