LOCUS NC_039195 15342 bp RNA linear VRL 24-AUG-2018
DEFINITION Avian paramyxovirus 8 strain goose/Delaware/1053/76, complete
genome.
ACCESSION NC_039195
VERSION NC_039195.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Avian metaavulavirus 8 (APMV-8)
ORGANISM Avian metaavulavirus 8
Viruses; Riboviria; Orthornavirae; Negarnaviricota;
Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae;
Avulavirinae; Metaavulavirus; Metaavulavirus delawarense.
REFERENCE 1 (bases 1 to 15342)
AUTHORS Paldurai,A., Subbiah,M., Kumar,S., Collins,P.L. and Samal,S.K.
TITLE Complete genome sequences of avian paramyxovirus type 8 strains
goose/Delaware/1053/76 and pintail/Wakuya/20/78
JOURNAL Virus Res. 142 (1-2), 144-153 (2009)
PUBMED 19341613
REFERENCE 2 (bases 1 to 15342)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (24-AUG-2018) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 15342)
AUTHORS Paldurai,A., Kumar,S., Subbiah,M., Collins,P.L. and Samal,S.K.
TITLE Direct Submission
JOURNAL Submitted (18-MAR-2015) Veterinary Medicine, University of
Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
REMARK Sequence update by submitter
REFERENCE 4 (bases 1 to 15342)
AUTHORS Paldurai,A., Kumar,S., Subbiah,M., Collins,P.L. and Samal,S.K.
TITLE Direct Submission
JOURNAL Submitted (17-SEP-2008) Veterinary Medicine, University of
Maryland, 8075 Greenmead Drive, College Park, MD 20742, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to FJ215863.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..15342
/organism="Avian metaavulavirus 8"
/mol_type="genomic RNA"
/strain="goose/Delaware/1053/76"
/host="Canada goose"
/db_xref="taxon:2560318"
/country="USA"
/collection_date="1976"
/acronym="APMV-8"
misc_feature 1..55
/note="leader"
gene 141..1526
/gene="N"
/locus_tag="D1Y18_gp1"
/db_xref="GeneID:37626938"
CDS 141..1526
/gene="N"
/locus_tag="D1Y18_gp1"
/codon_start=1
/product="nucleoprotein"
/protein_id="YP_009512951.1"
/db_xref="GeneID:37626938"
/translation="MSSVFNEYQALQEQLVKPAVRRPDVASTGLLRAEIPVCVTLSQD
PGERWSLACLNIRWLVSDSSTTPMKQGAILSLLSLHSDNMRAHATLAARSADASLTIL
EVDEVDIGNSLIKFNARSGVSDKRSNQLLAIADDIPKSCSNGHPFLDTDIETRDPLDL
SETIDRLQGIAAQIWVSAIKSMTAPDTASESESKRLAKYQQQGRLVKQVLLHSVVRTE
FMRVIRGSLVLRQFMVSECKRASAMGGDTSRYYAMVGDISLYIKNAGLTAFFLTLKFG
VGTQYPTLAMSVFSSDLKRLAALIRLYKTKGDNAPYMAFLEDSDMGNFAPANYSTMYS
YAMGIGTILEASVSRYQYARDFTSENYFRLGVETAQSQQGAFDERTAREMGLTEESKQ
QVRSLLMSVDMGPSSVHEPSRPAFISQEENRQPAQNSSDTQGQTKPVPKQPAPRADSD
DIDPYENGLEW"
misc_feature 339..1493
/gene="N"
/locus_tag="D1Y18_gp1"
/note="Paramyxovirus nucleocapsid protein; Region:
Paramyxo_ncap; pfam00973"
/db_xref="CDD:395775"
gene 1693..2910
/gene="P"
/locus_tag="D1Y18_gp2"
/db_xref="GeneID:37626933"
CDS 1693..2910
/gene="P"
/locus_tag="D1Y18_gp2"
/codon_start=1
/product="phosphoprotein"
/protein_id="YP_009512952.1"
/db_xref="GeneID:37626933"
/translation="MDFANDEEIAELLNLSTNVIKEIQKSELKPPQTTGRPPVSQGNT
RNLTDLWEKETASQTKTPAQSPQTTQVQSDENEEGEIKSESIDGHIRGTVNQSEQVPE
QNQSRSSPGDDLDRALNKLEGRINSISSMDKEIKKGPRIQNLPGSQAATQQATHPLAG
DTPNMQAQTKALAKPHQEAINPGNQDTGESIHLPPSMAPPESLVGAIRNAPQFVPDQS
MTNVDAGSVQLHASCAEMISRMFVEVISKLDKLESRLNDIAKVVNTTPLIRNDINQLK
ATTALMSNQIASIQILDPGNAGVRSLSEMKSVTKKAAVVIAGFGDDPTQIIEEGIMAK
DALGKPVPPTSVISAKAQTSSGVSKGEIEGLIALVETLVDNDKKAAKLIKMIDQVKSH
ADYARVKQAIYNA"
misc_feature 1693..1866
/gene="P"
/locus_tag="D1Y18_gp2"
/note="N-terminal region of Paramyxovirinae phosphoprotein
(P); Region: Soyouz_module; pfam14313"
/db_xref="CDD:316803"
misc_feature 2440..2898
/gene="P"
/locus_tag="D1Y18_gp2"
/note="C-terminal domain of Measles virus phosphoprotein
and related proteins; Region: MEV_P-protein-C_like;
cl03936"
/db_xref="CDD:413868"
gene 3086..4195
/gene="M"
/locus_tag="D1Y18_gp3"
/db_xref="GeneID:37626934"
CDS 3086..4195
/gene="M"
/locus_tag="D1Y18_gp3"
/codon_start=1
/product="matrix protein"
/protein_id="YP_009512953.1"
/db_xref="GeneID:37626934"
/translation="MAYTTLKLWVDEGDMSSSLLSFPLVLKETDRGTKELQPQVRVDS
IGDVQNAKESSIFVTLYGFIQAIKESTDRSKFFHPKDDFKPETVTAGLVVVGAIRMMA
DVNTISNDALALEITVKKSATSQEKMTVMFHNSPPSLRTAITIRAGGFISNADENIKC
ASKLTAGVQYIFRPMFVSITKLHNGKLYRVPKSIHSISSTLLYSVMLEVGFKVDIGKD
HPQAKMLKKVTIGDADTYWGFAWFHLCNFKKTSSKGKPRTLDELKTKVKNMGLKLELH
DLWGPTIVVQITGKSSKYAQGFFSSNGTCCLPISRSAPGLGKLLWSCSATIGDATVVI
QSSEKGELLRSDDLEIRGAVASKKGRLSSFHPFKK"
misc_feature 3131..4144
/gene="M"
/locus_tag="D1Y18_gp3"
/note="Viral matrix protein; Region: Matrix; pfam00661"
/db_xref="CDD:395535"
gene 4499..6130
/gene="F"
/locus_tag="D1Y18_gp4"
/db_xref="GeneID:37626935"
CDS 4499..6130
/gene="F"
/locus_tag="D1Y18_gp4"
/codon_start=1
/product="fusion protein"
/protein_id="YP_009512954.1"
/db_xref="GeneID:37626935"
/translation="MGQISVYLINSVLLLLVYPVNSIDNTLIAPIGVASANEWQLAAY
TTSLSGTIAVRFLPVLPDNMTTCLRETITTYNNTVNNILGPLKSNLDALLSSETYPQT
RLIGAVIGSIALGVATSAQITAAVALKQAQDNARNILALKEALSKTNEAVKELSSGLQ
QTAIALGKIQSFVNEEILPSINQLSCEVTANKLGVYLSLYLTELTTIFGAQLTNPALT
SLSYQALYNLCGGNMAMLTQKIGIKQQDVNSLYEAGLITGQVIGYDSQYQLLVIQVNY
PSISEVTGVRATELVTVSVTTDKGEGKAIVPQFVAESRVTIEELDVASCKFSSTTLYC
RQVNTRALPPLVASCLRGNYDDCQYTTEIGALSSRYITLDGGVLVNCKSIVCRCLNPS
KIISQNTNAAVTYVDATICKTIQLDDIQLQLEGSLSSVYARNISIEISQVTTSGSLDI
SSEIGNINNTVNRVEDLIHQSEEWLAKVNPHIVNNTTLIVLCVLSALAVIWLAVLTAI
IIYLRTKLKTISALAVTNTIQSNPYVNQTKRESKF"
misc_feature 4589..5965
/gene="F"
/locus_tag="D1Y18_gp4"
/note="Fusion glycoprotein F0; Region: Fusion_gly;
pfam00523"
/db_xref="CDD:395418"
gene 6383..8116
/gene="HN"
/locus_tag="D1Y18_gp5"
/db_xref="GeneID:37626936"
CDS 6383..8116
/gene="HN"
/locus_tag="D1Y18_gp5"
/codon_start=1
/product="hemagglutinin-neuraminidase protein"
/protein_id="YP_009512955.1"
/db_xref="GeneID:37626936"
/translation="MSNIASSLENIVEQDSRKTTWRAIFRWSVLLITTGCLALSIISI
VQIGNLKIPSVGDLADEVVTPLKTTLSDTLRNPINQINDIFRIVALDIPLQVTNIQKD
LASQFNMLIDSLNAIKLGNGTNLIIPTSDKEYAGGIGNPVFTVDAGGSIGFKQFSLIE
HPSFIAGPTTTRGCTRIPTFHMSESHWCYSHNIIAAGCQDASASSMYISMGVLHVSSS
GTPIFLTTASELIDDGVNRKSCSIVATRFGCDILCSIVTEKEGDDYWSDTPTPMRHGR
FSFNGSFVEAELPVSSMFSSFSANYPAVGSGEIVKDRILFPIYGGIKQTSPEFTELVK
YGLFVSTPTTVCQSSWTYDQVKAAYRPDYISGRFWAQVILSCALDAVDLSSCIVKIMN
SSTVMMAAEGRIMKIGIDYFYYQRSSSWWPLAFVTKLDPQELADTNSIWLTNSIPIPQ
SKFPRPSYSENYCTKPAVCPATCVTGVYSDIWPLTSSSSLPSIIWIGQYLDAPVRRTY
PRFGIANQSHWYLQEDILPTSTASAYSTTTCFKNTARNRVFCVTIAEFADGLFGEYRI
TPQLYELVRNN"
misc_feature 6866..8098
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="Hemagglutinin-neuraminidase (HN) of parainfluenza
virus 5, Newcastle disease virus, and related
paramyxoviridiae; Region: HN; cd15469"
/db_xref="CDD:271233"
misc_feature order(6878..6895,6965..6967,7001..7003,7028..7030,
7034..7036,7070..7072,7076..7078,8054..8065,8075..8077,
8081..8089)
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="dimer interface [polypeptide binding]; other site"
/db_xref="CDD:271233"
misc_feature 6905..7081
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="Sialidase propeller 1 [structural motif]; Region:
Sialidase propeller 1"
/db_xref="CDD:271233"
misc_feature order(6908..6910,6980..6982,7583..7585,7628..7630,
7898..7900,7982..7984,8045..8047)
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="active site"
/db_xref="CDD:271233"
misc_feature order(6908..6910,7160..7162,7283..7285,7337..7339,
7469..7474,7583..7585,7628..7630,7634..7636,7802..7804,
7898..7900,7982..7984)
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="receptor binding site [chemical binding]; other
site"
/db_xref="CDD:271233"
misc_feature 7088..7246
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="Sialidase propeller 2 [structural motif]; Region:
Sialidase propeller 2"
/db_xref="CDD:271233"
misc_feature 7271..7570
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="Sialidase propeller 3 [structural motif]; Region:
Sialidase propeller 3"
/db_xref="CDD:271233"
misc_feature 7574..7735
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="Sialidase propeller 4 [structural motif]; Region:
Sialidase propeller 4"
/db_xref="CDD:271233"
misc_feature 7808..7960
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="Sialidase propeller 5 [structural motif]; Region:
Sialidase propeller 5"
/db_xref="CDD:271233"
misc_feature 7976..8098
/gene="HN"
/locus_tag="D1Y18_gp5"
/note="Sialidase propeller 6 [structural motif]; Region:
Sialidase propeller 6"
/db_xref="CDD:271233"
gene 8297..15013
/gene="L"
/locus_tag="D1Y18_gp6"
/db_xref="GeneID:37626937"
CDS 8297..15013
/gene="L"
/locus_tag="D1Y18_gp6"
/codon_start=1
/product="large polymerase protein"
/protein_id="YP_009512956.1"
/db_xref="GeneID:37626937"
/translation="MDIKQVDLIIQPEVHLDSPIILNKLALLWRLSGLPMPADLRQKS
VVMHIPDHILEKSEYRIKHRLGKIKSDITHYCQYFNINLANLDPITHPKSLYWLSRLT
IASAGTFRHMKDRILCTVGSEFGHKIQDLFSLLSHKLVGNGDLFNQSLSGTRLTASPL
SPLCDQFVSDIKSAVTTPWSEARWSWLHIKQTMRYLIKQSCTTNSAHLTEIIKEEWGL
VGITPDLVILFDRVNNSLTALTFEMVLMYSDVLESRDNIVLVGRLSTFLQPVVSRLEV
LFDLVDSLAKILGDTIYEIIAVLESLSYGSVQLHDASHSHAGSFFSFNMNELDNTLSK
RVDPKHKNTIMSIIRQCFSNLDVDQAAEMLCLMRLFGHPMLTAPDAAAKVRKAMCAPK
LVEHDTILQTLSFFKGIIINGYRRSHSGLWPNVEPSSIYDDDLRQLYLESAEISHHFM
LKNYKSLSMIEFKKSIDYDLHDDLSTFLKDRAICRPKSQWDVIFRKSLRRSHTQSQYL
DEIKSNRLLIDFLDSAEFDPEKEFAYVTTMDYLHDNEFCASYSLKEKEIKTTGRIFAK
MTRNMRSCQVILESLLSKHICKFFKENGVSMEQLSLTKSLLAMSQLSPKVSTLQDTAS
RHVGNSKSQIATSNPSRHHSTANQMSLSNRKTVVATFLTTDLEKYCLQWRYSTIKLFA
QALNQLFGIDHGFEWIHLRLMNSTLFVGDPYSPPEDPTLEDIDKAPNDDIFIVSPRGG
IEGLCQKMWTMISISAIHCVAEKIGARVAAMVQGDNQVIAITKELFRGEKACDVRDEL
DELGQVFFDEFKRHNYAIGHNLKLNETIQSQSFFVYSKRIFFEGRLLSQVLKNAAKLC
MVADHLGENTVSSCSNLSSTIARLVENGFEKDTAFVLNLVYIMTQILFDEHYSIVCDH
HSVKSLIGSKNHRNLLYSSLIPGQLGGFNFLNISRLFTRNIGDPVTCSLSDLKCFIAA
GLLPPYVLKNVVLREPGPGTWLTLCSDPYTLNIPYTQLPTTYLKKHTQRSLLSRAVNP
LLAGVQVPNQHEEEEVLARFLLDREYVMPRVAHVILETSVLGKRKQIQGLIDTTPTII
RTSLVNLPVSRKKCEKIINYSLNYIAECHDSLLSQVCFSDNKEYLWSTSLISVETCSV
TIADYLRAVSWSNILGGRNISGVTTPDTIELIQGCLIGENSSCTLCESHDDAFTWMHL
PGPLYIPEPSVTNSKMRVPYLGSKTEERKTASMAAIKGMSHHLRAVLRGTSVFIWAFG
DTDINWDNALQIAQSRCNITLDQMRLLTPIPSSSNIQHRLDDGISTQKFTPASLARIT
SFVHICNDSQRLEKDGSSVDSNLIYQQIMLLGLSIFETMYSMDQKWVFNNHTLHLHTG
HSCCPRELDISLVNPPRHQTPELTSTTTNPFLYDQLPLNQENLTTLEIKTFKFNELNI
DGLDFGEGIQLLSRCTARLMAECILEEGIGSSVKNEAIVNFDNSVNWISECLMCDIRS
LCVNLGQEILCSLAYQMYYLRIRGRRAILNYLDTTLQRIPVIQLANIALTISHPEIFR
RIVNTGIHNQIKGPYVATTDFIAASRDIILSGAREYLSYLSSGQEDCYTFFNCQDGDL
TPKMEQYLARRACLLTLLYNTGHQIPVIRSLTPIEKCKVLTEYNQQIEYADQEFSSVL
KVVNALLQNPKIDALVSNLYFTTRRVLSNLRSCDKARSYIEYLYTEDFGEKEDTVQYD
IMTTNDIILTHGLFTQIEISYQGNSLHKFLTPDNAPGSLIPFSISPNSLACDPLHHLL
KSVGTSSTSWYKYAIAYAVSEKRSARLGGSLYIGEGSGSVMTLLEYLEPSVDIFYNSL
FSNGMNPPQRNYGLMPLQFVNSVVYKNLTAKSECKLGFVQQFKPLWRDIDIETNVTDP
SFVNFALNEIPMQSLKRVNCVVEFDRGMPIERVIQGYTHILLVATYGLQQDSILWVKV
YRTSEKVFQFLLSAMIMIFGYVKIHRNGYMSTKEEEYILMSDCKEPVNYTAVPNILTR
VSDLVSKNLSLIHPEDLRKVRCETDSLNLKCNHIYEKIIARKIPLQVSSTDSLLLQLG
GVINSVGSTDPREVATLSSIECMDYVVSSIDLAILEANIVISESAGLDLALMLGPFNL
NKLKKIDTILKSSTYQLIPYWLRYEYSINPRSLSFLITKLQQCRISWSDMITISEFRK
KSKRPIFIKRVIGNQQLKSFFNESSSIVLTRAEVKVCIKFLGAIIKLK"
misc_feature 8333..11638
/gene="L"
/locus_tag="D1Y18_gp6"
/note="Mononegavirales RNA dependent RNA polymerase;
Region: Mononeg_RNA_pol; pfam00946"
/db_xref="CDD:395756"
misc_feature 12032..15004
/gene="L"
/locus_tag="D1Y18_gp6"
/note="mRNA capping enzyme, paramyxovirus family; Region:
paramyx_RNAcap; TIGR04198"
/db_xref="CDD:275046"
misc_feature 15172..15342
/note="trailer"
ORIGIN
1 accaaacaag gaatgcaaga ccaacgggaa ctttaaataa aacaatcgaa ttattggggg
61 cgaagcaagt ggatctcgag ctcgaggccg aaaccctgaa tttcactgga ggttttgaat
121 aggtcgctat aggactcaat atgtcatctg tattcaatga gtatcaggcg cttcaagaac
181 aacttgtaaa gccggctgtc aggagacctg atgttgcctc aacgggttta ctcagagcgg
241 aaatacctgt ctgtgtcaca ttatctcaag accccggtga gagatggagc cttgcttgct
301 tgaatatcag atggcttgtg agtgattcat caaccacacc aatgaagcaa ggagcaatat
361 tgtcactgct gagtctacat tcagacaata tgcgagctca cgcaacatta gcagcaaggt
421 ctgcagatgc ttcactcacc atacttgagg tagatgaagt agatattggc aactcactaa
481 tcaaattcaa cgccagaagt ggtgtatctg ataaacgctc aaatcaattg cttgcaattg
541 cggatgacat ccccaaaagt tgcagtaatg ggcatccatt tcttgacaca gacattgaga
601 ccagagaccc gctcgatcta tcagagacta tagaccgcct gcagggtatt gcagctcaga
661 tatgggtgtc agccataaag agcatgacag cgcctgacac cgcatcagag tcagaaagta
721 agaggctggc caaatatcaa caacaaggcc gactggttaa gcaagtactc ttgcattctg
781 tagtcaggac agaatttatg agagttattc ggggcagctt ggtactgcgc cagtttatgg
841 ttagcgagtg caagagggct tcagccatgg gcggagacac atctaggtac tatgctatgg
901 tgggcgacat cagtctgtac atcaagaatg caggattgac tgcatttttc ctcaccctga
961 agttcggagt tggtacccag tatccaacct tagcaatgag tgttttctcc agtgacctta
1021 aaaggcttgc tgcactaatc aggctataca aaaccaaggg agacaatgca ccatacatgg
1081 cattcctgga ggactccgat atgggaaatt ttgctccagc aaattatagc acaatgtact
1141 cttatgccat gggcattggg acaattctgg aagcatctgt atctcgatac cagtatgcca
1201 gagactttac cagtgagaat tatttccgtc ttggagttga gacagcccaa agccagcagg
1261 gagcatttga cgagagaaca gcccgagaaa tgggcttgac tgaggaatca aaacagcagg
1321 ttagatcact gctaatgtca gtagacatgg gtcccagttc agttcatgag ccatctcgcc
1381 ctgcatttat cagtcaagaa gaaaataggc agcctgccca gaactcgtca gatactcagg
1441 gtcagaccaa gccagtcccg aagcagcccg caccaagggc cgactcagat gacattgatc
1501 catacgagaa cgggctagaa tggtaattca accaccccga cacatccacc tatacaccaa
1561 ttctgtgaca tattaaccca atcaaacatt tcataaacta tagtagtcat tgatttaaga
1621 aaaaattggg ggcgacctca attgtgaaac ataccagatc cgtccacaac accactcaac
1681 aacccacaca caatggattt cgccaatgat gaagaaattg cagaactttt gaatctcagc
1741 accaatgtaa tcaaggagat tcagaaatcc gaactcaagc ctccccaaac caccggacga
1801 ccacctgtca gtcaagggaa cacaagaaat ctaactgatc tatgggaaaa agagactgca
1861 agtcagacca agacaccggc ccaatctcca caaaccacac aagttcagtc tgatgaaaat
1921 gaggagggag aaatcaagtc cgagtcaatt gatggccaca tcagaggaac tgttaatcaa
1981 tcagagcaag tcccagaaca aaaccagagc agatcttcac caggtgatga tctcgacaga
2041 gctctcaaca agcttgaagg gagaatcaat tcaatcagct caatggacaa agaaattaaa
2101 aagggccctc gcatccagaa tctccctggg tcccaggcgg caactcaaca ggcgacccac
2161 ccattggcag gggacacccc gaacatgcaa gcacagacaa aagccctggc gaagccacat
2221 caagaggcaa tcaatcctgg caaccaggac acaggagaga gtattcattt accaccttcc
2281 atggcaccac cagagtcatt agttggtgca atccgcaatg caccccaatt cgtgccagac
2341 caatctatga cgaatgtaga tgcggggagt gtccaactac atgcatcatg tgcagagatg
2401 ataagtagaa tgtttgtaga agttatatcc aagcttgata aactcgagtc gagactgaat
2461 gatatagcaa aagttgtgaa caccaccccc cttattagga atgatattaa ccaacttaag
2521 gccacaaccg cactgatgtc caaccaaatt gcttccatac aaattcttga cccagggaat
2581 gcaggggtga ggtccctctc tgaaatgaaa tctgtgacga agaaagctgc tgttgtaatt
2641 gcagggtttg gagacgaccc aactcaaatt attgaagaag gcattatggc caaagatgct
2701 cttggaaaac ctgtgcctcc aacatctgtt atctcagcta aagctcagac ttcttccggt
2761 gtgagtaagg gtgaaataga aggattgatt gcattggtgg aaacattagt tgacaatgac
2821 aagaaggcag caaaactgat taaaatgatt gatcaagtta aatcccacgc cgattacgcc
2881 cgagtcaagc aggcaatata taatgcgtaa tactgtaact atacaaacaa tcaatactgc
2941 tgtcggttgc acccacctca gcaaatcaat aatcttttag aatttattga ttaagaaaaa
3001 attgactact ataaggaaag aacaccaagt tgggggcgaa gacacgattg accacagtcg
3061 ctatctgtaa ggctcctcac caaaaatggc atatacaaca ttgaaactgt gggtggatga
3121 gggtgacatg tcgtcttcgc tcctatcatt cccgttggta ctaaaagaga cagacagagg
3181 cacaaaggag cttcaaccac aggtaagggt agattcaatt ggcgatgtgc agaacgccaa
3241 agagtcctcg atattcgtga ctctatatgg tttcatccaa gcaattaagg agagtacaga
3301 tcgatcgaaa ttcttccatc caaaagatga cttcaaacct gagacagtca ctgcaggact
3361 ggtagtggta ggtgcgatcc gaatgatggc tgatgttaat accatctcta atgacgcact
3421 agcgctggag atcactgtta agaaatctgc aacttctcaa gagaaaatga cggtgatgtt
3481 ccacaatagc cccccttcat tgagaactgc aataactatc cgagcaggag gtttcatctc
3541 gaatgcagac gagaatataa aatgtgccag caagttgact gcaggagtgc agtacatatt
3601 ccgcccaatg tttgtttcaa tcactaaatt acacaatggc aaactatata gggtgcccaa
3661 aagcatccac agcatctcgt ccactctact gtatagtgtg atgttggagg taggattcaa
3721 agtggatatt gggaaggatc atccccaggc aaagatgctg aagaaggtca caatcggcga
3781 tgcagacaca tactgggggt ttgcatggtt ccacctgtgc aatttcaaaa agacatcctc
3841 taagggaaag ccaagaacgc tagacgaact aaagacaaaa gtcaaaaaca tggggttgaa
3901 attggagtta catgacttgt ggggtccgac tattgtggtc caaatcactg gcaagagcag
3961 caaatatgct caaggatttt tttcctccaa tggtacttgt tgcctcccaa tcagcagatc
4021 tgcaccaggg cttgggaagc ttctgtggtc ctgttcagca actatcggtg acgcaacagt
4081 tgttatccag tcaagcgaga aaggggaact cctaaggtct gatgacctcg agatacgagg
4141 tgctgtggcc tccaagaaag gtagactgag ctcatttcac cccttcaaga aatgatgcag
4201 gacatagtac agagaattag agagccatta gatgtgcgca aaaaacataa cctgcgatga
4261 actgcccaga ctccacttta acctaggttg cagggaaata gtacacgaca tgcacaatac
4321 tatcacggtc accagcaatc aataaagttg atcaatcact atattaggaa tcaaatagga
4381 taacaattat taatccaatt tcctaattat aaaaaattgc tttaaaggtt attgacgagt
4441 cgggggcgaa atcttgccac ttagtctgca gtcaatctta gaatctacat attgaactat
4501 gggtcaaata tcagtatatc taattaatag cgtgctatta ttgctggtat atcctgtgaa
4561 ttcgattgac aatacactca ttgccccaat cggagttgcc agcgcaaatg aatggcagct
4621 tgctgcatat acaacatcac tttcagggac aattgccgtg cgattcctac ctgtgctccc
4681 ggataatatg actacctgtc ttagagaaac aatcactaca tataataata ctgtcaacaa
4741 catcttaggc ccactcaaat ccaatctgga tgcactgctc tcatctgaga cttatcccca
4801 gacaagatta attggggcag ttataggttc aattgctctc ggtgttgcaa catcggctca
4861 aatcactgct gcagttgctc tcaagcaagc gcaagacaat gcaaggaaca tactagcact
4921 caaagaagca ctgtccaaaa ccaatgaggc ggtcaaggag cttagtagtg ggttacaaca
4981 aacagctatt gcacttggta agatacagag ttttgtgaat gaggaaattc tgccatctat
5041 caaccaactg agctgcgagg tgacagccaa taaacttggg gtgtatttat ctctgtatct
5101 cacagaactg accaccatat tcggtgcaca gctgactaac cctgcattga cttcattatc
5161 atatcaagcg ctgtacaacc tgtgtggtgg caacatggca atgcttactc agaagattgg
5221 aattaaacaa caagacgtta attcgctata tgaagccgga ctaatcacag gacaagtcat
5281 tggttatgac tctcagtacc agctgctggt catccaggtc aattatccaa gcatttctga
5341 ggtcactggt gtacgtgcaa cagaattagt cactgttagt gtaacaacag acaagggtga
5401 agggaaagca attgtacccc aatttgtagc tgaaagtcgg gtgactattg aagagcttga
5461 tgtagcatct tgtaaattca gcagcacgac cctatattgc aggcaggtca acacaagggc
5521 acttcccccg ctagtagcta gctgtcttcg aggtaactat gatgattgtc aatataccac
5581 agagattgga gcattatcat cccggtatat aacactagat gggggggtct tagttaattg
5641 taagtcaatt gtttgtaggt gccttaatcc aagtaagatc atctctcaaa atacaaacgc
5701 tgcagtaaca tatgttgatg ccacaatctg caaaacaatt caattggatg atatacaact
5761 ccagctggaa gggtcactat catcagttta tgcaagaaac atctcaattg agatcagtca
5821 ggtgaccacc tccgggtctt tagatatcag cagtgagata ggaaacatca ataatacggt
5881 gaatcgtgtg gaggatttaa ttcaccaatc agaggaatgg ctggcaaagg ttaacccaca
5941 cattgttaat aatacaacac taatcgtact ctgtgtgtta agtgcgcttg ctgtgatctg
6001 gctggcagta ttaacggcta ttataatata cttgagaaca aagttgaaga ctatatcggc
6061 attagctgta accaatacaa tacagtctaa cccctatgtt aaccaaacga aacgtgaatc
6121 taagttttga tcattcaagc caaaacagag gatctaggct cgggttaata atagttcaat
6181 caatgtttga tttattaggt ttttcccact aattattaat atattcgtga ttagatgata
6241 acgttaaaag tcttaaatat ttaataaaaa atgtaacctg ggggcgaccc atttataggt
6301 tagtatatat taggaagtcc ttatattgca ctgtaatttc aaacaattat attacctcat
6361 atctaccttg tctaaagaca tcatgagtaa cattgcatcc agtttagaaa acattgtaga
6421 gcaggatagt cgaaaaacaa cttggagagc catctttaga tggtccgttc ttcttatcac
6481 aacaggatgc ttagccttat ccattattag catagttcaa attggaaatt tgaaaattcc
6541 ttctgtaggg gatctggctg atgaagtggt gacacccttg aaaaccactc tgtctgatac
6601 actcaggaat ccaattaacc agataaatga catatttagg attgttgccc ttgatattcc
6661 attgcaagtg accaatatcc aaaaagacct tgcaagtcaa tttaacatgt tgatagatag
6721 tttaaatgct atcaaattag gcaacgggac caaccttatc atacctacat cagacaagga
6781 gtatgcagga ggaattggaa accctgtatt tactgtcgat gctggaggtt ctataggatt
6841 caaacagttt agcttaatag aacatccgag ctttattgct ggacctacaa cgacccgagg
6901 ctgtacaaga atacccactt ttcacatgtc agaaagtcat tggtgctact cacacaacat
6961 catcgctgct ggctgtcaag atgccagtgc atccagtatg tatatctcaa tgggagttct
7021 ccatgtgtcc tcatctggca ctcccatttt tcttactact gcaagtgagc tgatagacga
7081 tggagttaac cgtaagtcat gcagcattgt agcaacccga tttggctgtg acattttgtg
7141 cagtattgtc acagagaagg agggagatga ttactggtct gatactccga ctccaatgcg
7201 ccacggccgt ttttcattca atggtagttt tgtagaagcc gaactaccag tgtccagtat
7261 gttctcgtca ttctctgcca actaccctgc tgtgggatca ggcgaaattg taaaagatag
7321 aatattattc ccaatttacg gaggtataaa gcagacttca ccagagttta ccgaattagt
7381 gaaatacgga ctctttgtat caacacctac aactgtgtgc cagagtagct ggacttatga
7441 ccaggtaaaa gcagcgtata ggccagatta catatcaggc cggttctggg cacaagtgat
7501 actcagctgc gctcttgatg cagtcgactt atcaagttgt attgtaaaga ttatgaatag
7561 cagcacagtg atgatggcag cggaaggaag gataatgaag atagggattg attactttta
7621 ctatcagcgg tcatcttctt ggtggccatt ggcatttgtt acaaaactag acccgcaaga
7681 attggcagac acaaactcaa tatggctgac caattccata ccaatcccgc aatcaaagtt
7741 ccctcggcct tcatattcag aaaattattg cacaaagcca gcagtttgcc ctgctacttg
7801 tgtcactggt gtgtactctg atatttggcc cctgacctca tcttcatcac tcccgagcat
7861 aatttggatc ggccagtacc ttgatgctcc tgttagaagg acttatccca gatttggaat
7921 tgcaaatcag tcacactggt acctccaaga agatattcta cccacttcca ccgcaagtgc
7981 gtattcaacc actacatgtt ttaagaatac tgccaggaat agagtgttct gcgtcaccat
8041 tgccgaattt gcagatgggt tgtttggaga gtacaggata acacctcagt tgtacgaatt
8101 agtgagaaat aattgaataa cgataatttt gagactcatt ttgtcgcaaa gtgaaattgt
8161 catctttaaa aataatcaat tctatgattt ttattgaaca tgattaagca atcatgtggg
8221 aaatttatta tctcataaat tctaatagtt gtaaatgacg aattaagaaa aaatggaggg
8281 cgacctctac acaaacatgg atataaaaca agttgacctg ataatacaac ccgaggttca
8341 tctcgattca cccatcatat tgaataaact ggcactatta tggcgcttga gtggtttacc
8401 catgcctgca gacctacgac aaaaatccgt agtgatgcac atcccggacc acatcttaga
8461 aaaatcagaa tatcggatca agcaccgtct agggaaaatc aagagtgaca taacacatta
8521 ctgccagtat tttaatatta atttggcaaa tcttgatccg ataacccacc ccaaaagttt
8581 gtattggtta tccagactaa caatagctag tgctggaacc tttagacata tgaaagatag
8641 aatcttgtgt acagttggct ctgaattcgg acacaaaatt caagatttat tttcactgtt
8701 gagccataaa ctagtaggta acggtgattt atttaatcaa agtctctcag gtacacgttt
8761 gactgcgagt ccgttatccc ctttatgcga tcaatttgtc tctgacatca agtctgcagt
8821 cacgacaccc tggtcagaag ctcgttggtc ttggcttcat atcaaacaaa caatgagata
8881 tctaataaaa caatcatgca ctacaaattc ggctcattta acagaaatca taaaagagga
8941 atggggttta gtaggtatta ctccagatct tgtcattctt tttgacagag tcaataatag
9001 tctgactgca ttaacatttg agatggttct aatgtattca gatgtattag aatcccgtga
9061 caatattgtg ttagtggggc gactatctac ctttctacag ccagtagtta gtagactgga
9121 ggtgttgttt gatctagtag attcattggc aaaaatctta ggtgacacaa tatatgagat
9181 tattgcagtg ttagagagct tgtcttatgg gtcagttcaa ctacatgatg caagtcactc
9241 tcatgcaggg tctttttttt catttaacat gaatgaactt gataacacac tatcaaagag
9301 ggtagatccg aaacacaaga acaccataat gagcattata agacaatgct tttctaatct
9361 agatgttgat caagctgcag agatgctatg cctgatgaga ttattcggac acccaatgtt
9421 aactgcaccg gatgcagcag ccaaagtgag gaaagcaatg tgtgctccaa aacttgttga
9481 acacgacacc atcttgcaga cattatcttt cttcaagggg ataattataa atgggtacag
9541 aagatcacac tctggcctgt ggcccaatgt agagccgtct tcaatttatg atgatgatct
9601 cagacagctg tacttagagt cagcagagat ttcccatcat ttcatgctta aaaactacaa
9661 gagtttgagc atgatagaat tcaagaagag catagactac gatcttcatg atgacttaag
9721 tactttctta aaggatagag caatttgccg gccgaaatcc cagtgggatg tcatatttcg
9781 taaatcttta cgcagatctc atacgcagtc ccagtatcta gacgaaatta agagcaaccg
9841 gttgctaatt gattttcttg attctgctga atttgaccct gaaaaagaat ttgcatatgt
9901 aaccacaatg gattatttgc acgataatga attttgtgct tcatattctc taaaggaaaa
9961 ggagatcaaa actactggga ggatatttgc aaaaatgaca cgcaatatga gaagttgcca
10021 agtaatactt gaatctttgt tatcaaagca tatatgcaag ttcttcaaag agaatggcgt
10081 ttcgatggag caattgtcat tgaccaagag tctacttgca atgtctcaac tctcaccaaa
10141 agtctcgact ttgcaggaca ctgcatcacg tcatgtaggc aactcaaaat ctcagattgc
10201 aaccagcaac ccatctcggc atcactcgac agccaatcag atgtcactct caaatcgaaa
10261 aacggttgta gcaactttct taacaactga cttggaaaaa tactgcctgc agtggcgata
10321 ctcaactatt aaattgtttg cacaagctct aaatcaactc tttgggattg atcacggatt
10381 tgaatggata catttaagac ttatgaacag caccttattt gttggcgatc cttactcgcc
10441 tcctgaagat ccaacactag aagatataga taaagcacca aatgatgata tcttcatagt
10501 ttctccaagg ggaggcatag agggtttatg tcagaaaatg tggaccatga tatcaattag
10561 tgctatacac tgtgtagcag agaaaattgg tgcacgagtg gcagcaatgg tgcagggtga
10621 taatcaagta atagctatca ccaaagaact attcagagga gaaaaagctt gtgatgtcag
10681 agatgagtta gacgagcttg gtcaagtgtt ttttgatgag ttcaagagac acaattatgc
10741 aattggacac aatcttaagc taaatgagac aatacaaagc caatcctttt ttgtatattc
10801 caaacgaata ttctttgaag ggcgattgct tagtcaagtc ctcaaaaatg ctgccaagtt
10861 atgtatggtt gctgaccatc taggtgaaaa cactgtatct tcctgtagca acctgagctc
10921 gacaattgcc cgcttggtgg aaaatgggtt tgagaaggac actgcttttg tgttgaacct
10981 agtctacatc atgactcaga ttctttttga tgagcattac tcgattgtat gcgatcacca
11041 tagtgtcaaa agtttgattg gatcaaaaaa ccatcggaat ttattgtact catctctaat
11101 accaggtcag ctcggcggtt tcaacttcct caatataagt cggttgttca ctaggaatat
11161 aggtgaccca gtaacatgta gtctgtctga tctcaaatgc ttcatagccg caggtctcct
11221 tccaccctat gtcctaaaaa atgtggttct gcgtgagcct ggtcctggga catggttgac
11281 gttgtgctct gatccttaca cccttaacat accatacaca cagcttccaa ccacatatct
11341 caaaaagcac acccagcgat cattgctttc acgtgcagta aatcctttat tagccggtgt
11401 acaagtgcca aatcagcatg aggaagaaga ggtgttggct cgctttctcc ttgatcgtga
11461 atatgtgatg ccccgcgttg ctcatgtaat actagaaaca tcggtccttg gcaaacggaa
11521 acaaatccaa ggcttaattg atacaactcc aaccatcatt agaacatctc tagttaatct
11581 gccagtgtct agaaagaaat gcgaaaaaat aatcaattac tctctcaatt atattgctga
11641 gtgtcatgac tccttactta gccaggtctg cttcagtgat aataaggaat acttgtggtc
11701 aacctcctta atatcagttg agacatgtag tgtgacaatc gcggactatc tgagagctgt
11761 cagctggtct aatatattag ggggaagaaa catatccggg gtgactacac ctgatactat
11821 tgaattaatt caaggttgtt taataggtga aaattctagt tgtactcttt gtgaatcgca
11881 tgatgacgca ttcacgtgga tgcacttgcc tggcccactt tacatccctg aaccatcagt
11941 tactaactct aaaatgcgtg tgccatatct gggttcgaaa acagaggagc gtaaaacagc
12001 ctcaatggca gcaataaaag gaatgtcaca tcacctgcgt gcagtcttaa gaggcacatc
12061 cgtatttatt tgggcatttg gggatacaga tattaattgg gataatgcat tgcagattgc
12121 ccaatcacgg tgtaacatca cattggatca aatgagatta cttacaccaa ttcctagcag
12181 ttcaaatatt caacatagac tcgatgacgg aatcagcacg cagaaattta ctcctgcaag
12241 ccttgctcga atcacatcct tcgttcacat ctgtaatgac agccagaggt tagagaagga
12301 tggctcatct gttgactcaa acttgattta ccagcaaatt atgttacttg gactcagcat
12361 ctttgaaaca atgtactcaa tggaccaaaa gtgggtattc aataaccata ccttgcattt
12421 gcacactgga cactcctgtt gtccaaggga actagacata agtttggtga acccgccgag
12481 acatcagacc ccggagctga ctagcacaac aaccaacccg ttcctatatg atcagctccc
12541 attaaatcaa gaaaacttga caacacttga gattaagaca tttaaattca atgagctcaa
12601 cattgatggt ttagattttg gtgaaggaat acaattattg agtcgttgta ctgcaagatt
12661 gatggcagaa tgtattctag aggagggaat aggctcgtca gttaaaaatg aagcaattgt
12721 caattttgat aattcagtca attggatttc agagtgccta atgtgtgata ttcgctcact
12781 ttgtgttaat ttaggtcaag agatactatg tagcctggca taccaaatgt attacttgcg
12841 aatcaggggt agacgggcca ttcttaatta cttggacaca actttgcaaa ggatccctgt
12901 gatacaatta gccaacattg cactcaccat ttcgcaccct gagatatttc gcagaattgt
12961 caacaccggg atccataacc agattaaggg cccatatgtc gcaacaacgg atttcatagc
13021 tgcaagtaga gatatcatat tatcaggtgc aagggagtat ctatcttatt taagcagtgg
13081 gcaggaagac tgttacacat tcttcaactg tcaagatggg gatcttactc caaaaatgga
13141 acagtatctt gcaaggaggg catgcctttt aacattattg tataatactg ggcaccagat
13201 ccccgttatc cgatcactga caccaataga gaagtgcaag gtgctcacag aatacaatca
13261 acaaattgag tatgcagatc aagagtttag ctctgtatta aaagtggtca atgcactact
13321 acaaaatcct aagatagatg cattagtttc aaatctctac ttcaccacca gacgtgttct
13381 atcaaacctc agatcatgtg ataaggctag atcatatatt gaatatttgt acactgagga
13441 cttcggagag aaagaggata cagtacaata tgacatcatg acaacaaacg atatcatact
13501 tactcatggt ctattcacac agatcgaaat atcttatcaa gggaatagtc tccataagtt
13561 ccttactccg gataacgcgc ctggatcttt gatcccattc tctatttcac caaattcact
13621 tgcatgtgat cctcttcatc acttgctcaa gtcggtcggt acatcaagca caagttggta
13681 caagtatgca atcgcctatg cagtgtctga aaagaggtca gctcgattag gagggagctt
13741 gtacattggt gaagggagcg gaagtgtgat gactttactc gagtatcttg agccatctgt
13801 tgacatattt tacaattcac tcttctcaaa tggtatgaac ccaccacaac gaaattatgg
13861 gcttatgcca ctacaatttg tgaattcggt ggtttataag aacttaacgg ctaaatcaga
13921 atgtaagcta gggtttgtcc agcaatttaa accgttgtgg agagacatag acattgagac
13981 taatgttaca gatccatcat ttgtcaattt tgcattgaat gaaatcccaa tgcaatcatt
14041 aaaacgagta aattgtgttg tggaatttga ccgtggtatg ccgattgaac gggttattca
14101 gggttatacc catatcttac ttgttgctac ttacggatta cagcaagatt caatactgtg
14161 ggtgaaggta tataggacat ctgaaaaagt atttcaattc ttactgagtg ccatgatcat
14221 gatctttggt tatgtcaaaa tccacaggaa tggttatatg tcgacaaagg aggaagagta
14281 catattgatg tctgactgca aggaacctgt aaactataca gctgtcccta acattcttac
14341 acgtgtaagt gatttagtgt cgaagaatct gagtcttatc catccagaag acctcagaaa
14401 agtaaggtgt gaaacagatt ccctgaattt gaagtgcaat catatttatg agaaaataat
14461 tgccagaaaa attccattac aggtatcatc aactgattct ttgctcctcc aattaggcgg
14521 tgttatcaac tcggtgggct caactgatcc tagagaggtt gcaacattat cttctattga
14581 gtgtatggac tatgttgtct catcaattga tttggctata ttggaggcaa atattgtaat
14641 ctcagagagt gctggtcttg acctcgcttt aatgttaggc ccattcaact tgaataagct
14701 taagaaaatt gatacaatcc ttaagtcaag cacctatcag ctaatcccgt actggttgcg
14761 ctatgagtac tctattaatc cgagatcttt gtcatttcta atcactaaat tacaacaatg
14821 ccgaatttca tggtcagata tgatcacgat ttctgaattt cgtaagaaat ccaagcggcc
14881 tatatttatc aaacgagtaa tagggaatca acagctaaaa tcattcttta atgaaagctc
14941 aagtattgtt ttgactcggg ctgaagttaa agtctgtata aagttcctcg gtgcaatcat
15001 caagttgaaa taatttctgc gattttaaag gggtgtaatg ttctaatttg cacttggagt
15061 aatatagctt gtaatcattc gataggggat aggataattt ctctaacctc tgaatctata
15121 tccctagagt ataacaaata tatacataat aaaaatgatt ttaagaaaaa atccgacact
15181 caaagaaaat tggtgcctgt aatattcttc ttgccagatg attgtggagt gtctagccta
15241 acttaaaaca atcgtattcg atagggaaga atggtatata aaataactaa taaaaaaatg
15301 tattagtaaa aattaccgta tttcctgtat tccatttctg gt
//
