LOCUS NC_039218 10376 bp RNA linear VRL 24-MAY-2019
DEFINITION Kyasanur forest disease virus polyprotein gene, complete cds.
ACCESSION NC_039218
VERSION NC_039218.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Kyasanur Forest disease virus
ORGANISM Kyasanur Forest disease virus
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
Amarillovirales; Flaviviridae; Orthoflavivirus; Orthoflavivirus
kyasanurense.
REFERENCE 1 (bases 1 to 10376)
AUTHORS Grard,G., Moureau,G., Charrel,R.N., Lemasson,J.J., Gonzalez,J.P.,
Gallian,P., Gritsun,T.S., Holmes,E.C., Gould,E.A. and de
Lamballerie,X.
TITLE Genetic characterization of tick-borne flaviviruses: new insights
into evolution, pathogenetic determinants and taxonomy
JOURNAL Virology 361 (1), 80-92 (2007)
PUBMED 17169393
REFERENCE 2 (bases 1 to 10376)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (24-AUG-2018) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 10376)
AUTHORS Charrel,R.N., Lemasson,J.-J., Grard,G., Garbutt,M., Feldmann,H. and
de Lamballerie,X.
TITLE Direct Submission
JOURNAL Submitted (13-JUN-2003) Unite des Virus Emergents, Universite de la
Mediterranee, Faculte de Medecine, 27 Blvd. Jean Moulin, Marseille
13005, France
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to AY323490.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..10376
/organism="Kyasanur Forest disease virus"
/mol_type="genomic RNA"
/db_xref="taxon:33743"
gene 1..10251
/gene="POLY"
/locus_tag="D1Y39_gp1"
/db_xref="GeneID:37627194"
CDS 1..10251
/gene="POLY"
/locus_tag="D1Y39_gp1"
/codon_start=1
/product="polyprotein"
/protein_id="YP_009513189.1"
/db_xref="GeneID:37627194"
/translation="MAKGAVLKGKGGGPPRRVPKETAKKTRQGPGRLPNGLVLMRMMG
VLWHMVAGTARNPILKRFWATVPVRQAIAALRKIRKTVGLLLDSLNKRRGKRRSTTGL
LTPILLACLATLVFSATVRRERTGNMVIRAEGKDAATQVEVMNGTCTILATDMGSWCD
DSIMYECVTIDSGEEPVDVDCFCKGVERVSLEYGRCGKPAGGRNRRSVSIPVHAHSDL
TGRGHKWLKGDSVKTHLTRVEGWVWKNKFLTAAFCAVVWMVTDSLPTRFIVITVALCL
APTYATRCTHLQNRDFVSGTQGTTRVSLVLELGGCVTLTAEGKPSVDVWLDDIHQENP
AKTREYCLHAKLANSKVAARCPAMGPATLPEEHQASTVCRRDQSDRGWGNHCGLFGKG
SIVACAKFSCEAKKKATGYVYDVNKITYVVKVEPHTGDYLAANESHSNRKTASFTTQS
EKTILTLGDYGDISLTCRVTSGVDPAQTVVLELDKTAEHLPKAWQVHRDWFEDLSLPW
RHGGAQEWNHADRLVEFGEPHAVKMDIFNLGDQTGILLKSLAGVPVANIEGSKYHLQS
GHVTCDVGLEKLKMKGMTYTVCEGSKFAWKRPPTDSGHDTVVMEVTYTGSKPCRIPVR
AVAHGEPNVNVASLITPNPSMETTGGGFVELQLPPGDNIIYVGELSHQWFQKGSTIGR
VLEKTRRGIERLTVVGEHAWDFGSVGGMLSSVGKALHTAFGAAFNTIFGGVGFLPRIL
LGVALAWLGLNSRNPTLSVGFLITGGLVLTMTLGVGADMGCAIDANRMELRCGEGLVV
WREVTDWYDGYAFHPESPSVLAASLKEAYEEGICGIVPQNRLEMAMWRRVEAVLNLAL
AESDANLTVVVDKRDPSDYRGGKVGTLRRSGKEMKTSWKGWSQSFVWSVPEAPRRFMV
GVEGAGECPLDKRRTGVFTVAEFGMGMRTKVFLDLRETASSDCDTGVMGAAVKSGHAV
HTDQSLWMRSHRNATGVFISELIVTDLRNCTWPASHTLDNAGVVDSKLFLPAGLAGPR
SHYNHIPGYAEQVKGPWSQTPLRVVREPCPGTAVKIDQSCDKRGASLRSTTESGKAIP
EWCCRTCELPPVTFRSGTDCWYAMEIRPVHQQGGLVRSMVLADNGAMLSEGGVPGIVA
VFVVLELVIRRRPTTGTSVVWCGMVVLGLVVTGLVTIEGLCRYVVAVGILMSMELGPE
IVALVLLQAVFDMRTGLLVAFAVKRAYTTREAVATYFLLLVLELGFPEASLSNIWKWA
DSLAMGALILQACGQEGRTRVGYLLAAMMTQKDMVIIHTGLTIFLSAATAMAVWSMIK
GQRDQKGLSWATPLAGLLGGEGVGLRLLAFRKLAERRNRRSFSEPLTVVGVMLTVASG
MVRHTSQEALCALVAGAFLLLMMVLGTRKMQLTAEWCGEVEWNPDLVNEGGEVNLKVR
QDAMGNLHLTEVEKEERAMALWLLAGLVASAFHWAGILIVLAVWTLFEMLGSGRRSEL
VFSGQETRTERNRPFEIKDGAYRIYSPGLLWGHRQIGVGYGAKGVLHTMWHVTRGAAL
VVDEAISGPYWADVREDVVCYGGAWSLESRWRGETVQVHAFPPGRPQETHQCQPGELI
LENGRKLGAVPIDLSKGTSGSPIINAQGEVVGLYGNGLKTNEAYVSSIAQGEAEKSRP
EIPLSVQGTGWMSKGQITVLDMHPGSGKTHRVLPELVRQCADRGMRTLVLAPTRVVLK
EMERALAGKKVRFHSPAVEGQTTAGAIVDVMCHATYVHRRLLPQGRQNWEVAIMDEAH
WTDPHSIAARGHLYSLAKENRCALVLMTATPPGRGDPFPESNGAIMSEERAIPDGEWR
VGFDWITEYEGRTAWFVPSISKGGAVARTLRQRGKSVICLNSKTFEKDYLRVREEKPD
FVVTTDISEMGANLDVSRVIDGRTNIKPEEVDGKVELTGTRKVTTASAAQRRGRVGRT
SGRTDEYIYSGQCDDDDTSLVQWKEAQILLDNITTLRGPVATFYGPEQVKMPEVAGHY
RLNEEKRKHFRHLMTQCDFTPWLAWHVATNTSNVLDRSWTWQGPEENAIDGADGDLVR
FKTPGGSERVLQPVWKDCRMFREGRDVKDFILYASGRRSVGDVLGGLAGVPGLLRHRC
ASALDVVYTLLNENPGSRAMRMAERDAPEAFLTIVEVAVLGVATLGILWCFVARTSVS
RMFLGTVVLFAALFLLWIGGVDYGHMAGIALIFYTLLTVLQPEPGKQRSSDDNRLAYF
LLGLFSLAGLVTANEMGMLDKTKADLAGLVWRGEQRHPAWEEWTNVDIQPARSWGAYV
LIVSLFTPYMLHQLQTKIQQLVNSSVASGAQAMRDLGGGTPFFGVAGHVIALGVTSLV
GATPMSLGLGVALAAFHLAIVASGLEAELTQRAHRVFFSAMVKNPMVDGDVINPFPDG
ETKPALYERRMSLILAIALCMGSVVLNRTAASMTEAGAVGLAALGQLVHPETETLWTM
PMACGMAGLVRGSFWGLLPMGHRLWLRTTGTRRGGAEGETLGDIWKRRLNGCSREEFF
QYRRSGVMETERDKARELLKRGETNMGLAVSRGTAKLAWLEERGYATLKGEVVDLGCG
RGGWSYYAASRPAVMGVKAYTIGGKGHEVPRLITSLGWNLIKFRTGMDVYSLEAHRAD
TILCDIGESSPDPLAEGERSRRVILLMEKWKLRNPDASCVFKVLAPYRPEVLEALHRF
QLQWGGGLVRVPFSRNSTHEMYFSTAISGNIINSVNTQSRKLLARFGDQRGPTKVPEV
DLGTGTRCVVLAEDKVREADVAERIAALKTQYGDSWHVDKEHPYRTWQYWGSYKTEAT
GSAASLINGVVKLLSWPWNAREDVVRMAMTDTTAFGQQRVFKEKVDTKAQEPQVGTKI
IMRAVNDWIFERLAGKKTPRLCTREEFIAKVRSNAALGAWSDEQNRWPNAREAVEDPE
FWRLVDEERERHLGGRCAQCVYNMMGKREKKLGEFGVAKGSRAIWYMWLGSRYLEFEA
LGFLNEDHWASRDLSGAGVEGTSLNYLGWHLKKLSELEGGLFYADDTAGWDTRITNAD
LEDEEQILRYLEGEHRTLAKTILEKAYHAKVVKVARPSSSGGCVMDIITRRDQRGSGQ
VVTYALNTLTNIKVQLIRMMEGEGVIGPSDSQDPRLLRVEAWLKEHGEERLTRMLVSG
DDCVVRPIDDRFGKALYFLNDMAKVRKDIGEWEPSEGYSSWEEVPFCSHHFHELTMKD
GRVIIVPCRDQDELVGRARVSPGCGWSVRETACLSKAYGQMWLLSYFHRRDLRTLGLA
ICSAVPIDWVPQGRTTWSIHASGAWMTTEDMLEVWNRVWILDNPFMGDKGKVREWRDI
PYLPKSQDGLCSSLVGRRERAEWAKNIWGSVEKVRRMIGPERYADYLSCMDRHELHWD
LKLESNII"
misc_feature 10..345
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Flavivirus capsid protein C; Region: Flavi_capsid;
pfam01003"
/db_xref="CDD:366413"
misc_feature 619..843
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Flavivirus envelope glycoprotein M; Region:
Flavi_M; cd17038"
/db_xref="CDD:341208"
misc_feature order(619..621,625..654,658..666,670..675,700..702,
790..792,823..825)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="glycoprotein E binding interface [polypeptide
binding]; other site"
/db_xref="CDD:341208"
misc_feature 847..1746
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Flavivirus glycoprotein, central and dimerization
domains; Region: Flavi_glycoprot; pfam00869"
/db_xref="CDD:395698"
misc_feature 1774..2028
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Immunoglobulin-like domain III (C-terminal domain)
of Flavivirus envelope glycoprotein E; Region: Flavi_E_C;
cl28075"
/db_xref="CDD:332896"
misc_feature order(1789..1794,1798..1803,1822..1827,1954..1956)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:213392"
misc_feature order(1810..1812,1858..1860,1915..1926,1930..1932)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="low pH domain interface [polypeptide binding];
other site"
/db_xref="CDD:213392"
misc_feature order(1813..1815,1858..1860,1909..1917,1966..1968)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="low pH trimer interface [polypeptide binding];
other site"
/db_xref="CDD:213392"
misc_feature 2041..2331
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="flavivirus envelope glycoprotein E, stem/anchor
domain; Region: flavi_E_stem; TIGR04240"
/db_xref="CDD:213897"
misc_feature 2338..3399
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Flavivirus non-structural Protein NS1; Region:
Flavi_NS1; pfam00948"
/db_xref="CDD:279316"
misc_feature 4534..4980
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Peptidase S7, Flavivirus NS3 serine protease;
Region: Peptidase_S7; pfam00949"
/db_xref="CDD:395758"
misc_feature 5044..5481
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Flavivirus DEAD domain; Region: Flavi_DEAD;
pfam07652"
/db_xref="CDD:400138"
misc_feature order(5074..5094,5341..5346)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:350689"
misc_feature 5497..5907
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="C-terminal helicase domain of the DEAD-like
helicases; Region: DEAD-like_helicase_C; cl38915"
/db_xref="CDD:365791"
misc_feature 5860..5862
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:350171"
misc_feature 6346..6777
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Flavivirus non-structural protein NS4A; Region:
Flavi_NS4A; pfam01350"
/db_xref="CDD:279666"
misc_feature 7561..8265
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="Cap-0 specific (nucleoside-2'-O-)-methyltransferase
of flaviviridae; Region: capping_2-OMTase_Flaviviridae;
cd20761"
/db_xref="CDD:394920"
misc_feature order(7576..7578,7585..7590,7594..7596,7987..7992,
8185..8187)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="nucleic acid substrate binding site [nucleotide
binding]; other site"
/db_xref="CDD:394920"
misc_feature order(7780..7788,7795..7800,7849..7854,7927..7932,
7975..7980)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="SAM binding site [chemical binding]; other site"
/db_xref="CDD:394920"
misc_feature order(7975..7977,8086..8088,8194..8196)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="active site"
/db_xref="CDD:394920"
misc_feature 8500..10191
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="catalytic core domain of RNA-dependent RNA
polymerase (RdRp) in the genus Flavivirus, within the
family Flaviviridae of positive-sense single-stranded RNA
(+ssRNA) viruses; Region: Flavivirus_RdRp; cd23204"
/db_xref="CDD:438054"
misc_feature order(8746..8748,8758..8760,8779..8784,8974..8976,
8986..8988,8998..9000,9019..9021,9346..9366,9916..9918,
9925..9927,9931..9933)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="inhibitor binding site [chemical binding];
inhibition site"
/db_xref="CDD:438054"
misc_feature 8902..8967
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="conserved polymerase motif F; other site"
/db_xref="CDD:438054"
misc_feature order(8911..8913,8962..8964,8968..8970,8986..8988,
8998..9000,9010..9012,9022..9024,9061..9063,9067..9075,
9346..9357,9361..9366,9523..9534,9667..9672,9727..9729,
9751..9753,9799..9804,9811..9816,9820..9825)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="RNA binding site [nucleotide binding]; other site"
/db_xref="CDD:438054"
misc_feature order(8914..8916,8923..8925,8947..8949,8956..8958,
9157..9159,9343..9348,9373..9375,9529..9534,9670..9672,
9727..9729,9751..9753,9922..9930)
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="NTP binding site [chemical binding]; other site"
/db_xref="CDD:438054"
misc_feature 9127..9171
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="conserved polymerase motif A; other site"
/db_xref="CDD:438054"
misc_feature 9340..9411
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="conserved polymerase motif B; other site"
/db_xref="CDD:438054"
misc_feature 9502..9552
/gene="POLY"
/locus_tag="D1Y39_gp1"
/note="conserved polymerase motif C; other site"
/db_xref="CDD:438054"
ORIGIN
1 atggccaaag gagccgtcct taaaggaaag gggggcggtc cccctaggcg agtgccgaaa
61 gagaccgcaa aaaagacgcg tcaaggacca ggccgattgc caaacggact ggtattgatg
121 cgcatgatgg gagtgctgtg gcatatggtc gctggaacgg ccaggaatcc gatcctcaag
181 cgattctggg cgactgttcc ggtacggcag gccattgcag cgctccgtaa aatccgaaag
241 acagttggac tgctattgga ctctttaaat aaaagaagag ggaagagaag gtcaaccacc
301 ggattgctca cgccaatctt gctagcttgc ctggcgaccc tggtgttctc tgcgacagtt
361 cgcagagaga gaacagggaa catggtgatc agggcagaag gaaaggacgc agccacgcaa
421 gtggaagtca tgaatggaac atgcaccatt cttgccacag acatggggag ttggtgtgat
481 gattcaatca tgtacgagtg tgtcaccatt gactcgggag aagaaccagt tgatgtggat
541 tgcttctgca aaggcgttga gcgagtgtca ctggaatacg gaaggtgtgg gaaaccagct
601 ggcggtagaa acaggaggtc agtgtcgatt ccggtgcatg ctcatagtga tctcaccgga
661 agagggcaca agtggcttaa aggggactca gtcaagacac atctgacacg tgtggaaggc
721 tgggtttgga aaaacaagtt cctgacagcg gccttttgtg cagttgtgtg gatggtaacg
781 gacagcctgc cgacaaggtt cattgtcata acggtggccc tttgcctggc tcctacatat
841 gccacacgat gcacacacct gcagaaccgg gactttgtct cagggaccca agggacgact
901 agagtttcat tggtgttgga attaggcggc tgtgtcaccc tcacagctga aggcaagcca
961 tcagtggatg tttggctcga cgacatacac caggagaacc cggccaagac acgagagtat
1021 tgtcttcatg ccaagctggc aaactccaag gtggccgcac gttgtccagc catgggtcca
1081 gcgacactgc cagaggagca ccaggcgagc acagtctgta gacgagacca gagtgacaga
1141 ggctggggta accattgtgg actgttcggg aagggcagca ttgtggcttg tgccaagttt
1201 agctgtgagg ccaaaaagaa ggcaactgga tatgtgtacg atgtcaacaa aatcacatat
1261 gtggtgaagg tggaacctca cacgggtgac tatctagcgg ccaacgagtc gcacagcaac
1321 cggaagacag catctttcac aacgcagtcc gagaagacca tcttgacact gggagattat
1381 ggagacatct ccctcacgtg ccgggtgact agtggagtgg atcctgccca gactgtggta
1441 ttggaactgg acaagacagc ggaacacttg cccaaggctt ggcaggtaca ccgagactgg
1501 tttgaggacc tctccttgcc atggcgacac gggggtgccc aggaatggaa ccatgctgac
1561 cggctcgtgg aatttggtga accgcacgct gtgaaaatgg acatttttaa ccttggggac
1621 cagacgggta tcctgttgaa gtctctggct ggagtgcccg tggctaacat agagggcagc
1681 aagtaccatc tccagagtgg tcatgtcacc tgcgatgtgg gccttgaaaa acttaagatg
1741 aaagggatga catacacggt ttgtgaggga tcaaaatttg cttggaaaag gccgccaacc
1801 gacagtggac atgataccgt agtcatggag gtgacttaca ccgggagcaa gccatgcaga
1861 ataccagtga gagccgtggc ccatggagaa cccaatgtta acgtggcaag tctaataacc
1921 ccaaacccat ccatggaaac aactggagga gggttcgttg agctacagct accaccagga
1981 gacaacatca tctatgttgg tgagctgagc caccagtggt ttcagaaggg cagcacaatt
2041 ggccgtgttc tggaaaagac caggaggggc atagagagac tcacagttgt gggagagcac
2101 gcctgggact tcggttcggt aggcggcatg ctatcatcag tggggaaggc tctacacacg
2161 gcttttggcg cagcatttaa taccattttt ggaggggtgg gattcctccc acgcattctg
2221 ctgggggtag ctctggcttg gctggggctc aactcacgga accccaccct ttcagtcggc
2281 tttttgatta ctggtggact tgtgttgaca atgacactgg gggttggtgc tgatatgggc
2341 tgtgcaattg atgctaacag gatggagcta cgatgtggtg agggccttgt tgtgtggaga
2401 gaggtcaccg actggtatga tggttacgca ttccacccag aatcgccctc tgtccttgcg
2461 gcatctctaa aagaagcata tgaggaagga atttgtggta ttgtgcccca gaaccggctt
2521 gagatggcca tgtggaggcg tgtggaggct gtgctcaact tggccctcgc agagagtgat
2581 gctaatctaa cggtggttgt ggacaaaaga gatcccagtg actacagggg aggcaaagtg
2641 ggaaccctaa ggcgttcagg caaggaaatg aagacgtcat ggaagggatg gagccaatcc
2701 tttgtgtgga gtgtcccaga agcgccacgg cgttttatgg ttggggttga gggggctgga
2761 gagtgtcctc ttgacaaacg ccgaacagga gtcttcacag tggcagagtt tgggatggga
2821 atgaggacca aggtcttctt ggacctacgt gagactgcct cctcagactg tgataccgga
2881 gtcatggggg ctgcagtcaa aagcggtcat gccgtccaca ccgaccaaag tctttggatg
2941 aggtcgcaca ggaatgcaac gggagtgttc atatctgagt tgatagtgac cgacctacgg
3001 aactgcacat ggccagccag ccacaccttg gacaacgccg gtgtcgtgga ctcaaaactc
3061 ttccttccag caggcctggc tggaccacgg tcgcactaca atcacattcc tgggtacgca
3121 gaacaggtta aggggccatg gagccaaacg cccctacggg tggtaaggga accctgccct
3181 gggactgcgg ttaagattga ccagagttgt gacaaaaggg gggcgtcgct gcgtagcacg
3241 acggaaagcg ggaaggccat accagaatgg tgttgccgca catgtgagct gcccccagtc
3301 acattccgta gtgggactga ttgctggtat gccatggaaa ttagaccagt ccaccaacag
3361 ggtggtctgg tgaggtcgat ggtgctggct gacaacggag ccatgctaag tgaaggtgga
3421 gtccctggca ttgtggctgt gttcgtggtc ctggagctgg tcatcaggag acgcccaaca
3481 actggcacct cagtggtgtg gtgtgggatg gttgtccttg gccttgttgt gactgggcta
3541 gtcaccattg agggcctatg ccgctatgtg gtggccgtcg gcatcttgat gagcatggag
3601 ctcggaccag agattgtggc actagttctg ctacaggcag tgtttgacat gaggactggc
3661 ctcctggtgg cttttgcagt caaaagggcc tacacaacta gagaggctgt ggcaacctat
3721 ttcttgctcc tcgtgctgga acttgggttt ccggaggcct cactgagtaa catctggaag
3781 tgggccgact ccttggcaat gggagcactg attctccagg cgtgtggtca ggagggtaga
3841 actcgagtgg gctatctcct ggcagctatg atgacccaaa aggacatggt aataatccac
3901 acaggcttga ccatttttct atcagctgcc acggcaatgg cggtctggag catgatcaag
3961 ggtcaacggg accagaaggg actttcctgg gccacaccac ttgcaggcct ccttggaggc
4021 gagggagtgg gtcttagatt gctggcgttt cgaaagcttg ccgagcgaag gaacagacgg
4081 tctttcagtg aaccactgac ggtggtggga gtcatgctca ctgtggcaag tgggatggtg
4141 agacacacat cccaggaagc actgtgcgct cttgtagctg gggcctttct cctcctcatg
4201 atggtactgg gaacacggaa gatgcagctc accgcagagt ggtgcggtga agtggaatgg
4261 aacccagacc tagtgaacga gggaggagag gttaatctga aagtgaggca ggacgccatg
4321 gggaatctcc atctcactga ggtggagaag gaagaacgtg cgatggcgtt atggcttctt
4381 gcagggttgg tggcttcagc cttccactgg gcaggcattc taatagtatt ggctgtgtgg
4441 acactttttg agatgctggg ctcggggcga aggtctgaac ttgtcttctc tggacaggag
4501 acccggaccg aaaggaatcg gccctttgag atcaaggatg gagcctatcg catctacagc
4561 cctggcttgc tttggggaca ccgccaaatt ggagtggggt atggagccaa gggagttctg
4621 cacaccatgt ggcacgtcac taggggggca gccctggttg tggatgaggc aatctctgga
4681 ccctattggg ctgacgtcag ggaagacgtt gtgtgctatg gtggagcatg gagtcttgag
4741 agccggtgga ggggtgagac cgttcaggtg cacgcgtttc caccagggag accccaagag
4801 acacaccagt gccagccggg tgaactcatc ctggagaatg gcaggaaact tggagcagtc
4861 cctattgacc tgagcaaagg cacctcggga agtcctatca ttaacgccca gggagaggtg
4921 gtgggtcttt atgggaacgg cctgaagacc aatgaagcct acgtcagcag catagcacaa
4981 ggagaagccg agaaaagcag accggaaatc ccgttgagtg tgcaaggaac aggctggatg
5041 tcaaaaggtc aaatcacggt gctggacatg catccggggt cagggaagac acatcgagtc
5101 ctcccggagc ttgtgaggca gtgtgcagac cgagggatga ggactctagt tcttgccccc
5161 acccgggtgg tcctgaagga gatggagaga gcgcttgctg gcaagaaggt ccgattccac
5221 tcacccgcgg tggaagggca gaccacagcg ggggccattg ttgacgtcat gtgccatgcc
5281 acgtacgtcc acagaaggct gctgccccaa gggagacaaa attgggaagt cgccataatg
5341 gatgaggccc attggactga tccgcacagt atcgcggcaa gagggcatct ttattcgctc
5401 gccaaagaga acaggtgcgc cttggtgctc atgacagcaa ctccacccgg ccggggagat
5461 cctttcccgg agtccaatgg agccattatg agtgaggaaa gggccattcc ggacggagag
5521 tggagagtgg gctttgactg gataacagag tatgagggtc gaacagcatg gttcgttcca
5581 tccatatcaa aaggtggggc ggttgcaaga accctgcgcc agagaggcaa aagtgtgatc
5641 tgtctcaaca gtaaaacctt tgagaaggat tacctgaggg tcagggaaga gaagccagat
5701 tttgtggtga caacagatat ctctgagatg ggtgccaacc tggatgtcag ccgagttatt
5761 gatggtagaa caaacataaa gccagaggag gtggatggaa aggtagagtt gactggaacc
5821 aggaaggtca cgacagcatc ggcggctcag cgccggggca gggtgggaag gacatctgga
5881 cgcactgatg agtacatata ctctggacag tgtgatgatg acgacaccag cctcgttcaa
5941 tggaaggagg cgcagatact cctggacaat atcaccacac tgaggggtcc ggtcgcaact
6001 ttttatggac ccgagcaggt gaagatgcca gaagtggctg gccactacag gctgaatgag
6061 gagaaaagga aacacttccg gcacttgatg actcaatgtg acttcactcc ctggctggcg
6121 tggcatgtcg ccaccaacac cagcaatgtg ttggatcgga gctggacctg gcaggggccg
6181 gaggaaaatg ccattgacgg ggccgacgga gatctggtgc ggtttaaaac gcctggcggc
6241 tcagaacgtg tcttgcagcc ggtgtggaag gactgcagaa tgttccgtga gggacgggac
6301 gtcaaagact tcatactgta cgcctccggg cgtcgcagtg ttggtgatgt tttgggtggt
6361 ctggcggggg tccccggtct cttgaggcac aggtgcgcca gcgcgcttga cgtagtttac
6421 acccttctca atgagaatcc gggcagcagg gcaatgcgca tggctgagag agatgcacca
6481 gaggcatttc tgactattgt tgaggttgct gttttaggag tggccactct tggcatactc
6541 tggtgctttg tggcaagaac ttcggtcagc cgcatgttcc tgggcacggt tgtgctcttt
6601 gctgccctct ttctgctgtg gattggtgga gtggactatg gacacatggc agggatagcc
6661 ctgatatttt acaccctcct cactgtgctg cagccagagc cgggaaaaca gcgaagtagc
6721 gatgacaaca gactggcata cttcctcctg gggcttttta gtttggctgg actcgtgacg
6781 gccaacgaaa tgggcatgtt ggacaagaca aaggctgacc ttgcagggct ggtgtggcgc
6841 ggagagcaga ggcatccagc ctgggaggag tggacaaatg tggacatcca accagcacga
6901 tcttgggggg cgtatgtgct gatcgtctct ctgttcactc cctacatgct gcaccagctt
6961 cagacaaaaa tacaacaact ggtgaacagt tcagtggcaa gtggtgctca ggctatgaga
7021 gatcttgggg gtgggacacc attcttcggg gtggccggcc atgtgattgc cttgggcgtc
7081 acgtcactcg tgggtgccac tcccatgtcc ttgggcttgg gggtggcttt ggctgctttc
7141 cacttggcca tcgtcgcctc gggattggaa gcagagctga cgcagagggc gcacagggta
7201 ttcttctcgg caatggttaa aaacccaatg gtggatggag acgtcatcaa tcccttcccc
7261 gatggagaga caaagccagc gctatacgag agaaggatga gtttaatcct ggccattgcc
7321 ttgtgcatgg gttcagtggt cctcaaccga accgcggcct caatgaccga ggctggggct
7381 gttggcctag cagcgctggg tcagctggtc catcccgaga ctgagacact ctggacaatg
7441 ccaatggcgt gtggtatggc ggggctcgtg cgggggagct tctggggcct gttgcccatg
7501 ggacaccgac tgtggcttag gacaactgga acacgcagag gaggtgccga gggagagact
7561 cttggggaca tctggaagag gcggctgaat ggttgctcta gggaggagtt ttttcagtac
7621 cggcgaagtg gagtcatgga gacggaacgt gacaaggctc gagagcttct gaagagaggt
7681 gagacaaaca tgggactggc tgtctctcga gggacggcta agctggcatg gctagaagaa
7741 cggggctatg cgaccttgaa aggtgaggtt gttgatctcg gctgtggcag aggcgggtgg
7801 tcatactacg ctgcttccag gccagctgtc atgggagtga aggcctacac gataggaggg
7861 aaaggccatg aggtcccaag actgatcaca agcctcggat ggaacctcat caagtttagg
7921 accggaatgg atgtgtactc cctagaggca cacagggctg acaccatcct ttgtgacatt
7981 ggtgagagta gtccggatcc cctggcggaa ggagagagga gccgccgtgt catcctcctc
8041 atggagaaat ggaaactccg caaccctgac gcgtcctgcg tgttcaaggt tttggctccg
8101 tacagaccag aggtgcttga ggctctccac agattccagc ttcaatgggg cggggggttg
8161 gtccgcgtcc ctttctcccg caattccacg catgagatgt acttctccac tgcgatcagt
8221 ggtaacatta tcaactcagt gaacactcag tccaggaagt tgttggccag atttggggat
8281 cagcggggac ccaccaaggt ccccgaggtg gatctgggaa ctggcacacg ctgtgtggta
8341 ctggcagaag acaaggtcag ggaagctgat gtggccgaaa gaatagctgc cctcaagacc
8401 caatatggtg attcttggca tgtggacaaa gaacatccat acagaacatg gcaatattgg
8461 ggaagctaca agacagaggc cacaggttcg gctgcctctc tgatcaacgg agtggtgaaa
8521 ctcctcagtt ggccctggaa tgctagggag gatgtggtgc gcatggcaat gacggacaca
8581 acggcctttg gccagcagag ggtttttaag gaaaaggtgg acaccaaagc gcaggagccg
8641 caggtgggaa ccaagatcat catgagggcc gttaacgact ggatctttga aagacttgcg
8701 ggaaagaaaa caccacgact gtgcacgcga gaggaattca tcgcaaaggt gcgctcaaac
8761 gctgcgctcg gagcctggtc agatgaacaa aatcgctggc caaacgcccg agaagcagtg
8821 gaggaccccg agttttggag gctcgttgat gaggaaagag agagacatct tggaggacgg
8881 tgtgcccagt gtgtgtacaa catgatgggt aagagagaga agaaactcgg tgagttcggt
8941 gtcgccaagg ggagccgtgc catctggtac atgtggttgg ggagccggta tctggaattt
9001 gaggcactgg gtttcctcaa tgaagaccac tgggcttcca gggacctcag tggagcgggg
9061 gttgagggga ccagtcttaa ctacctggga tggcatttga agaagctgtc cgaactcgaa
9121 ggagggcttt tctatgccga cgacaccgcc ggctgggaca caagaatcac caatgcagac
9181 cttgaggatg aggagcaaat tctgcgttat ctggaaggcg aacaccgaac cctcgcaaag
9241 acaatcttgg aaaaagctta ccatgccaaa gtggtcaaag tggcgcgccc ctccagctcg
9301 ggaggctgcg tcatggacat cataaccaga agagaccaac gtggttcagg ccaggtggtg
9361 acctacgctc taaacaccct cacgaacatc aaggtgcagc ttatccgcat gatggaggga
9421 gagggcgtga tcgggccatc tgactcacag gacccgcgac tcctacgtgt ggaagcctgg
9481 ctgaaagagc atggagagga gcgcctgacc cgcatgctgg tcagtgggga tgattgcgtt
9541 gtgagaccaa ttgacgaccg cttcgggaag gccctctact tcctaaatga catggccaag
9601 gtgagaaagg acattggaga gtgggagccc tcagaaggtt actccagctg ggaggaggtc
9661 cccttttgtt cccaccattt ccatgagttg acgatgaagg atggcagggt cataatcgtc
9721 ccatgcagag accaagatga gttggtgggg cgggcaagag tgtcacctgg gtgtggctgg
9781 agcgttaggg aaacagcatg tctctcaaag gcctatggac agatgtggct gctgagctac
9841 ttccacagga gggacctgag gacgctcggc ctggcaatct gctcagctgt gcccattgat
9901 tgggtcccgc agggacgaac cacatggagc atccacgcga gtggagcgtg gatgaccaca
9961 gaggacatgc tggaagtgtg gaaccgggtc tggattcttg acaacccctt catgggggac
10021 aaagggaaag tgagagaatg gagggacatc ccgtacctcc ctaagtccca ggatgggctg
10081 tgctcttccc tggtgggacg ccgagaacgg gcggaatggg caaagaacat ctggggatca
10141 gtggagaaag tgaggagaat gatcggcccc gagaggtatg ctgattatct ctcctgcatg
10201 gacaggcatg agctccactg ggacctgaag ttggaaagca atatcatcta aatgcaccaa
10261 ccatctggga ccagacaaga caacaccctc accgtgtgac aggggcaatc gcggtaagga
10321 ttgaaggagc cccaacgacg aactgtggca gcacaccatt tggtgacggg aagctg
//
