LOCUS NC_048213 27464 bp RNA linear VRL 15-MAY-2020
DEFINITION Infectious bronchitis virus isolate Ind-TN92-03, complete genome.
ACCESSION NC_048213
VERSION NC_048213.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Infectious bronchitis virus
ORGANISM Infectious bronchitis virus
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
Gammacoronavirus; Igacovirus; Avian coronavirus.
REFERENCE 1 (bases 1 to 27464)
AUTHORS Senthil Kumar,V., Raja,A., Vijayarani,K. and Roy,P.
TITLE Complete genome sequencing of Infectious bronchitis virus
Ind/TN92/03
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 27464)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (15-MAY-2020) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 27464)
AUTHORS Senthil Kumar,V., Raja,A., Vijayarani,K. and Roy,P.
TITLE Direct Submission
JOURNAL Submitted (26-MAY-2015) Animal Biotechnology, Madras Veterinary
College, Vepery, Chennai, Tamil Nadu 600007, India
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to KR902510.
##Assembly-Data-START##
Assembly Method :: DNA Star-Laser gene v. 7.1.0
Sequencing Technology :: Sanger dideoxy sequencing
##Assembly-Data-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..27464
/organism="Infectious bronchitis virus"
/mol_type="genomic RNA"
/isolate="Ind-TN92-03"
/isolation_source="kidneys"
/host="chicken"
/db_xref="taxon:11120"
/country="India"
/collection_date="2003"
/genotype="Mass41"
gene 529..20423
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/db_xref="GeneID:55060244"
CDS join(529..12360,12360..20423)
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/ribosomal_slippage
/codon_start=1
/product="ORF1ab polyprotein"
/protein_id="YP_009824996.1"
/db_xref="GeneID:55060244"
/translation="MASSLKQGVSPKLRDVILVSKDIPEQLCDALFFYTSHNPKDYAD
AFAVRHKFDRSLQTGKQFKFETVCGLFLLKGVDKITPGVPAKVLKSTSKLADLEDIFG
VSPFARKYRHLLKTACQWSLTVETLDARAQTLDEIFDPTEILWLQVAAKIQVSAMAMR
RLVGEVTAKVMEALGSNLSALFQIVKQQIARIFQKALAIFENVSELPQRIAALKMAFA
KCAKSITVVVVERTLIVKEFAGTCLASINGAVAKFFEELPNGFMGSKIFTTLAFFKEA
AVKIVENIPNAPRGTKGFEVVGNAKGTQVVVRGMRNDLTLLDQKVEIPVESEGWSAIL
EGHLCYVFKSGDRFYAAPLSGNFALHDVHCCERVVCLSDGVTPEINDGLILAAIYSSF
SVSELMAALKKGEPFKFLGHKFVYAKDAAVSFTLAKAATIADVLKLFQSARAKVEDVW
SSFTEKSFEFWKLAYGKVRILEDFVRPQLVRLKWSMGILATVLGEGIWHLVSQVIYKV
GGLFTKVVDFCEKYWKGFCAQLKRPKLIVTETLCVLKGVAQHCFQLLLDAIHSMYKSF
KKCALGRIHGDLLFWKGGVHKIIQEGDEIWFDAIDSIDVEDLGVVQEKSIDFEVCDNV
TLPENQPGHMVQIQNEDKNYMFFRFKKDENIYYTPMSQLGVINVVCKAGGKTVTFGET
TVQEIPPPDVVPIKVSIECCGEHGTQFSRKPIKEPIEVETDFTVEQLLSVIYEKMCDD
LKLFPEAPEPPPFEKVSLVEKQGKDLDCIKSCHWIYRDYESDDDIEEEDAEECDTDSG
DAEECDTNSECEEEDEDTKGLALIQDQPSYKYPLPLEEDYSVYNGCIVHKDALDVVNL
PSGEETFVVNDCFEGAVKPLPQKVIDVLGDWGEAVDAQEQLCQQESTQAAFERSVEDS
IGGCEAMAEQSVVDEHELLLVVEENQHGVVYTPADLEGVKETAEEVDEFILIADVSKE
EVVPQGKGESQVEQEPIQVVKSQREKKAKKFRVKPATCEKPKFLEYKTCVGDLTVVIA
KALDEFKEFCIVNAANEHMSHGGGVAKAIADFFGPDFVEYCEDYVKKHGPQQRLVTPS
FVKGIQCENNVVGLRHGDINSRQKLVAAYKNVLVDGVVNYAVPVLSLGIFGVDFKMSI
DAMREAFEGCTIRVLLFSLSQEHIDYFDVTCKQKTLYLTEDGVKYRSVVVKPGDSLSQ
FGQVFAKNKAVFTADDVEDKEILFVPTTDKTVLEYYPLDAQKYVIYLQTLAQKWNVQY
RDNFLILEWRDGNCWISSAIVLLQAAKIRFKGFLSEAWAKLLGGDPTDFVAWCYASCN
AKVGDFSDANWLLANFAEHFDADYKNAFLKKRVSCNCGVKSYELRGLEACIQPVRATN
LLHFKTQYSNCPTSGASNTDEVFEASLPYLLLFATDGPATVDCDEDAVGTVVFVGSTN
SVHCDTQAARQAFDNLAKDRKFGKKSPYKTAMYTRFAFKNENPLPVAKHSKGKSKSVK
EDVSNLATSSKASFDNLTDFEQWYTSNIYESLKVQESPYNFDKYVSFKIKEDSKLQKT
LKVRCIKSVFDFRSKDGFIYKLSPDTDENSKAPVYYPVLDSISLRAIWVEGSANFVVG
HPNYYSKFLHIPTFWENAENFVKMGDKIGGVSMGLWRAEHLNKPNLERIFNIAKKAIV
GSSVVTTQCGKLFGKAATFVADKVGDGVVRNITDSIKGLCGFTRGHFERKMSLQFLKT
LMFFLFYFLKASVKSVVSSYKIVLCKVVFVTLLIVWIVYTSNPVMFTGIRVLDFVFEG
SLCGPYKDYGKDSFDVLRNCAGDFTCRVCLHDRDSLHLFKYAYSVEQIYKDAASGINF
NWNWLYLVFLILFVKPVAGFVIICYCVKYLVLSSTVLQTGVGFLDWFVKTVFSHFNFM
GAGFYFWLFYKIYVQVHHILYCKDGTCGVCKRVARSTRQEVSVVVGGRQQIVHVYTNS
GYNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYPVVDEACLVD
DFVNLKYKAATPGKDNASSAVKCFSVTNFLKKAVFLKEALKCEQISNDGFIVCNTQSA
HALEEAKNAAVYYAQYLCKPILILDQALYEQLIVEPVSKSVVDKVCSILSNIISVDTA
ALNYKAGTLRDALLSITKDEEAVDMAIFCHNHEVEYTGDGFTNVIPSYGIDIDKLTPR
DRGFLINADASIANLRVKNAPPVVWKFSELIKLSDSCLKYLISATVKSGVRFFITKSG
VKQVIACHTQKLLVEKKAGGVISGTFKWFMSCFKWLLIFEILFTACCLGYYYLEVNKS
FVHPMYDVNSTLHFEGFQVIDNGVLRDIVPEDNCFSNKSVNFDAFWGKSYENNKNCPI
VTVVIDGHGTVAVGFPGFVSWVMDGVMFVHKTQTDRRPWYIPTWFNTDIVGYTQDSNI
TEDSFYTSIALFSARCLYLSASNTRQLYCFNRENDAPGALPFGSIIPHRVYFQPKGVR
LKVPQQILHTPYLVKLVSDSYCRGSVCEYTKPGYRVSLDPQWVLFNDEYTSKPGVFCG
STVRELMFNMVSTFFTGVNPNIYMQLATMFLILVVIVLIFAMVIKFQGVFKAYATIVF
TIMLVWVINAFVLCVHSYNSVLAVILLVLYCYASLVKSRNTGIIMHCGLVTMVGLIVP
TCLSCCFLGFILYMYTPLFFWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVIRGSEFV
KLTNEIGDKFEAYLSAYARLNYYSGTGSEQDYLQACRAWLAYALDQYRNSGVEIVYLP
PRYSIGVSRLQTGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHVLGKFS
GDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLEGAVLILQTAVANAETPKYKFVKAN
CGDSFTIACSYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHL
ELPNALHTGTDLTGEFYGGLVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSQP
KWLESTTVSIEDYNKWASDNGLTPFSTSTAITKLCAISGIDVCKLLRTIMVESAQWGS
EPILGQYNFEDEYTPESVFNQIGGVRLQSSFVSKATSWFWSRCVLACFLFVLCAIVLF
TAVPLKFYVYAAVILLLAVFFISFTVKHVMAYMDTFLLPTLITVIIGVCAEVPFMYNT
LISQVVIFLSQWYDPVFFDTMVPWMLLPLVLYTAFKCVQGCYMNSFNTSLLMLYQFMK
FGFGIYTSSNTLTAYTEGNWELFFELVHTTVLANVSSNSLFGLFVFKCAKWMLYYCNA
TYLYNYVLLAVMVNCIGWLCTCYFGLYWWVNKVFGLSFGKYNFKVSVDQYRYMCLHKI
YPPKTVWEVFTTNILIQGIGGDRVFPISTVQSKLSDVKCTTVVLMQLLTKLNVEANSK
MHAYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLGEYCDDILKRSTVLQSV
TQEFSHIPSYAEYERAKSIYEKVLADSKNGGVTQQELAAYRNAANIAKSVFDRDLAVQ
KKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQANSGV
VPLATVPIVCSNKLTLVIPDPETWVKCVEVMHVTYSTVVWNIDCVTDADGTELHPTST
GSGLTYCISGDNIAWPLKVNLTRNGHNKVDVALQNNELMPHGVKTKACVAGVDQAHCS
VESKCYYTSISGSSVVAAITSSNSNLKVASFLNEAGNQIYVDLDPPCKFGMKVGDKVE
VVYLYLIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDPADTYC
KYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGVSVCLYCRAHIAHPGG
AGNLDARCQFKGSFVQIPTTEKDPVGFCLRNKVCTVCQCWIGYGCQCDLLRQPKPSVQ
SVAVASDFDKNYLNQGTGWQCGSAVTPSSWMWPDVVWRAFDVCNKESAGMFQNLKRKC
GRFQEVRDTEDGILEYCDSYFGVKQTTPSNYEHEKACYEELKSEVTADHDFFVFNKNI
FNISRQRLTKYTKMDFCYALRHFDPKDCEVLKEILVTYGCIEDYHPKWFEENKDWYDP
IENPKYYAMLAKMGPIVRRALLNAIEFSNLMVEKGYVGVITLDNQDLNGKFYDFGDFQ
KTAPGAGVPVFDTYYSYKMPIIAKTDAFAPERYFEYDVHKGYKSYDLLKYDYTEEKQE
LFQKYFKYWDQEYHPNCRDCSDDRCLIHCAYFTILFSRLVPQTSFGNLCRKVFVDGVP
FIATCGYHSKELGVIKNQDNTMSFSKMGLCQLMQFVGDPALFVGTSNNFVDLRTSCFS
VCALSSGITHQTVKPGHFNKDFYDSAEKAGMFKEGSSLPLKHFFYPQTGNAAIYDYEY
YRYIRPTMFDICQILFCFEETSKYFECYEGGCIPAGQVLVNNFDKSPGYPFNKFGRAR
LYYEKSLEEQDQLFESTKKNVLPTISQKNLKYAISAKNRARTVAGVSILSTKTNRQFH
QKILKSIVNTRNAPVVIGTTKFYGGWDNMLRNLIQGVEDPILMGWDYPKCDRAMPNLL
RIAASFVLARKHTICCTWSERVYWLYIECAQVLSETVLATGGIYVKPGGTCSGDATTA
YANSVFNIIQATSAIVARLLSVITRDIVYEDIMSLQYELYQQVYWRVNFDPAFVEKFY
SYFCKNFSLMILSDDGVVCYNNTLAKQGLVADISGFREVLYYQNNVFMADSKCWVEPD
LEKGPHEFCSQHTMLVEVDGEPRYLPYPDPSRILCACVFVGDLDKTESVAVMERYIAL
AIDAYPLVHHENEEYKKVFFVLLSYIRKLYQELSQNMLMDYSFVMDIDKGSKFWEQEF
YENMYRAPTTLQSCGVCVVCNSQTILRCGNCIRKPFLCCKCCYDHVMHTDHKNVLSIN
PYICSQLCCGEADVTKLYLGAMSYFCGNHKPKLSIPLVSNGTVFGIYRANCAGSENVD
DFNQLATTNWSIVQPYILANRCRDSLRRFAAETVKATEELHMQQFASAEVREVFSDRE
LILSWEPGKTRPPLKRNYGFTGYHFTRTSKVQLGDFTFEKGEGKDVVYYKATSTAKLS
EGDIFVLSSHNVVSLEAPTLCPQQTFSRFVILRPIVMVPECFVNNIPLYHLVGMQKRT
TVQGPPGSGISHFAIGLAAYLSIARVVFTACSHAAVDALCEKAFMFLIVEDCTRIVPQ
RTSVDCFSKFIAIDTGKKYILRSIMALPEVSCDILLVDQVSMMTNYEMSFIIGMINYQ
YVEYVGHPAQLPAPRTLLIGSLSPKDYIVVTNLLVCVIPDIFLAKCYRCPKKIVDTVS
TLVYVGKFIANIPESRQCFKVIVIIGISDVGQESGSAYNTTQLEFVKDFVCRNMEWRE
ATFISPYNAMNQRAYRMLGLIVQTVDSSQGSEYDYVIFCVTADSQHALNIIRFNVALT
RAKRGILVVMRQREELYSALMFTELESVASLQGTGLFIICNKELSGVHPAYAVTTMAL
AATYIVIEELAALVIVEAGSEITYKHLISLLGFKMSVNVEGCHNMFITRDEAIRNVRG
WVGFDVEATHACGTNIGTNLPFQVGFSTGAHFVVTPEGLVDTSIGNNFEPVNSKAPPG
EQFNHLRALFKSAKPWHVVRPRIVQMLADNLCNVSDCVVLVTWRHGLELTTLCFFVKI
GKDQVCSCGSRATTFNSHTQAYACWKHCLGFDFVYNPLLVEIQQGGYSGNLQFNHDFH
CNVHGHAHVTSADAIMTRCLAILYAFCQNVNWDLTYPHFANEDEVNSSCRYLQRTYLN
ACVDALKVNVVYDIGNPKGIKCVRRGDLNFRFYRSNPIVPNVKQFEYDYNQHKDKFAD
GLCMFWNCNVDCYPRYSLVCRYDTRNLSVFNLPGCNGGSLYVNKHAFHTPYFDRTSFR
NLKAMPFFFYDSSPCETIRVDGVAQDLVSLATKDWITKCNIGGAVCKKHAQMYADFVT
SYNAAVTAGFTFWVTSYFNPYNLWKSFSALQSIDNIAYNMYKRGHYDAIAGEMPIIVT
GNKVFVIGQGVEKAVFVNQTILPTSVAFELYGKRNIRTLPNNRFLKGLGVDVTNGFVI
WDYTNQTPLYRNTVKVCAYTDIEPNGLIVLYDDRYGDYQSFLAADNAVYISTQCYKRY
SYVEIPSNMLVQNGIPLKDGANLYVYKRVNGAFVTLPNTLNTQGRSYEIFEPRSDVER
DFLDMSEEDFVEKYGKDLGLLHILYGEIDKPQLGGLHTVIGMYRLLRENKLNAKSVTN
SDSDVMQNYFVLADNGSYKQVCTVVDLLLDDFLELLRNILNEYGTNKSKVVTVSIDYH
SINFMTWFEDGIIKTCYPQLQSAWTCGYNMPELYKVQNCVMEPCNIPNYGVGIALPSG
IMMNVAKYTQLCQYFSKTTMCVPHNMRVMHFGAGGDKGMDPGNTVLKQYLPEGTLLGE
NGDVEYVSEARVSGLSDCKKYKTEHKFDLVISDMYTDNDSKRKHEGVDANNGNDAVFI
YLSSFLRNNLALGGSFTVKVTETSWHEVLYDIAQDCAWWTMFCTAVNASCSEEFLVGV
NYLGASEKVKVSGKTLHANCIFRRTCNYLQTSAYSIFDVVKFDLCLKAMPVVNWKTEQ
KRDLVFNFIKCGKLLVRDVGNTSFTSDSFVCTM"
misc_feature 568..1641
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="Replicase polyprotein 1a N-terminal domain; Region:
Nsp2a_N; pfam17896"
/db_xref="CDD:375411"
misc_feature 2608..2859
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="first ubiquitin-like (Ubl) domain located at the
N-terminus of coronavirus SARS-CoV non-structural protein
3 (Nsp3) and related proteins; Region:
Ubl1_cv_Nsp3_N-like; cl28922"
/db_xref="CDD:452900"
misc_feature 3640..4020
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="X-domain (or Mac1 domain) of viral non-structural
protein 3 and related macrodomains; Region:
Macro_X_Nsp3-like; cd21557"
/db_xref="CDD:438957"
misc_feature order(3658..3666,3676..3696,3919..3924,3928..3942,
4015..4017)
/locus_tag="HO266_gp1"
/note="ADP-ribose binding site [chemical binding]; other
site"
/db_xref="CDD:438957"
misc_feature 4054..4965
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus papain-like protease; Region:
gammaCoV_PLPro; cd21733"
/db_xref="CDD:409650"
misc_feature order(4264..4266,4339..4341,4348..4359,4504..4512,
4516..4521,4528..4533,4627..4632,4645..4647,4684..4692,
4696..4698,4759..4764,4768..4773,4819..4821,4840..4845,
4921..4923)
/locus_tag="HO266_gp1"
/note="ubiquitin binding site [polypeptide binding]; other
site"
/db_xref="CDD:409650"
misc_feature order(4504..4512,4771..4776,4819..4821,4828..4830,
4846..4848,4921..4923)
/locus_tag="HO266_gp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:409650"
misc_feature 5755..7329
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="C-terminus of gammacoronavirus non-structural
protein 3, including transmembrane and Y domains; Region:
TM_Y_gammaCoV_Nsp3_C; cd21710"
/db_xref="CDD:409658"
misc_feature 5755..5820
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="TM1 [structural motif]; Region: TM1"
/db_xref="CDD:409658"
misc_feature 6064..6132
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="TM2 [structural motif]; Region: TM2"
/db_xref="CDD:409658"
misc_feature 7369..8550
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="coronavirus non-structural protein 4 (Nsp4)
transmembrane domain; Region: cv_Nsp4_TM; cd21473"
/db_xref="CDD:394836"
misc_feature 7369..7437
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="putative TM helix 1 [structural motif]; Region:
putative TM helix 1"
/db_xref="CDD:394836"
misc_feature 8206..8271
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="putative TM helix 2 [structural motif]; Region:
putative TM helix 2"
/db_xref="CDD:394836"
misc_feature 8314..8379
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="putative TM helix 3 [structural motif]; Region:
putative TM helix 3"
/db_xref="CDD:394836"
misc_feature 8458..8526
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="putative TM helix 4 [structural motif]; Region:
putative TM helix 4"
/db_xref="CDD:394836"
misc_feature 8593..8862
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="Coronavirus nonstructural protein 4 C-terminus;
Region: Corona_NSP4_C; pfam16348"
/db_xref="CDD:406690"
misc_feature 8875..9792
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 5, also
called Main protease (Mpro); Region: gammaCoV_Nsp5_Mpro;
cd21667"
/db_xref="CDD:394888"
misc_feature order(8875..8877,8881..8883,8887..8904,8911..8913,
9229..9246,9274..9288,9361..9375,9721..9723,9727..9732,
9766..9771)
/locus_tag="HO266_gp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:394888"
misc_feature order(8944..8952,8992..8994,9283..9300,9352..9363,
9379..9381,9424..9441)
/locus_tag="HO266_gp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:394888"
misc_feature 9754..10671
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 6; Region:
gammaCoV-Nsp6; cd21559"
/db_xref="CDD:394845"
misc_feature 10672..10920
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 7; Region:
gammaCoV_Nsp7; cd21828"
/db_xref="CDD:409254"
misc_feature order(10675..10677,10684..10695,10702..10710,10714..10719,
10726..10728,10753..10755,10762..10764,10780..10782,
10816..10833,10837..10854,10873..10887)
/locus_tag="HO266_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409254"
misc_feature 10921..11550
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 8; Region:
gammaCoV_Nsp8; cd21832"
/db_xref="CDD:409259"
misc_feature order(10930..10938,10945..10950,10954..10959,10969..10971,
10987..10992,11122..11124,11131..11133,11140..11145,
11167..11172,11179..11184,11188..11196,11200..11208,
11212..11232,11236..11244,11248..11253,11260..11265,
11269..11271,11275..11280,11287..11298,11377..11379)
/locus_tag="HO266_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409259"
misc_feature 11545..11883
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 9; Region:
gammaCoV_Nsp9; cd21899"
/db_xref="CDD:409332"
misc_feature 11551..11568
/locus_tag="HO266_gp1"
/note="N-finger; other site"
/db_xref="CDD:409332"
misc_feature order(11557..11565,11569..11574,11761..11769,11812..11814,
11830..11835,11839..11847,11851..11859,11863..11868)
/locus_tag="HO266_gp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409332"
misc_feature 11887..12288
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 10; Region:
gammaCoV_Nsp10; cd21902"
/db_xref="CDD:409327"
misc_feature order(11887..11910,11920..11922,11926..11934,11938..11946,
11959..11964,11971..11976,11983..11985,12004..12021,
12058..12063,12091..12093,12097..12102,12112..12114,
12118..12135,12160..12168,12175..12186)
/locus_tag="HO266_gp1"
/note="Nsp14 interface [polypeptide binding]; other site"
/db_xref="CDD:409327"
misc_feature order(11926..11934,11938..11946,11959..11961,12004..12006,
12010..12021,12058..12066,12118..12129,12136..12138,
12181..12186,12238..12240)
/locus_tag="HO266_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409327"
misc_feature order(11959..11961,12010..12021,12058..12066,12136..12138,
12181..12186,12238..12240)
/locus_tag="HO266_gp1"
/note="homotrimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409327"
misc_feature order(12004..12027,12058..12063,12091..12102,12115..12120,
12124..12126,12175..12186)
/locus_tag="HO266_gp1"
/note="Nsp16 interface [polypeptide binding]; other site"
/db_xref="CDD:409327"
misc_feature join(12346..12360,12360..15137)
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus RNA-dependent RNA polymerase, also
known as non-structural protein 12: responsible for
replication and transcription of the viral RNA genome;
Region: gammaCoV_RdRp; cd21587"
/db_xref="CDD:394891"
misc_feature order(13149..13163,13311..13316,13320..13322,13326..13340,
13356..13367,13374..13376,13446..13448,13455..13460,
13464..13469,13476..13478,13482..13496,13500..13520,
13530..13532,13536..13538,13548..13553,13563..13565,
13857..13862,13869..13871,13884..13889,13893..13895,
13899..13910,14337..14339)
/locus_tag="HO266_gp1"
/note="putative Nsp8 interaction site [polypeptide
binding]; other site"
/db_xref="CDD:394891"
misc_feature order(13569..13583,13587..13589,13602..13604,13629..13631,
13635..13637,13662..13679,13989..13991,13995..13997,
14868..14870)
/locus_tag="HO266_gp1"
/note="putative Nsp7 interaction site [polypeptide
binding]; other site"
/db_xref="CDD:394891"
misc_feature order(13836..13838,13842..13850,13974..13976,14010..14012,
14016..14018,14034..14036,14046..14048,14058..14060,
14070..14072,14109..14111,14115..14117,14121..14123,
14385..14396,14403..14405,14613..14624,14778..14783,
14835..14837,14859..14861,14910..14915,14925..14927,
14931..14936)
/locus_tag="HO266_gp1"
/note="putative RNA binding site [nucleotide binding];
other site"
/db_xref="CDD:394891"
misc_feature 13842..13883
/locus_tag="HO266_gp1"
/note="conserved polymerase motif G; other site"
/db_xref="CDD:394891"
misc_feature 13953..14021
/locus_tag="HO266_gp1"
/note="conserved polymerase motif F; other site"
/db_xref="CDD:394891"
misc_feature order(13986..13988,14379..14387,14400..14402,14412..14414,
14616..14618)
/locus_tag="HO266_gp1"
/note="inhibitor binding site [chemical binding];
inhibition site"
/db_xref="CDD:394891"
misc_feature 14172..14222
/locus_tag="HO266_gp1"
/note="conserved polymerase motif A; other site"
/db_xref="CDD:394891"
misc_feature order(14193..14195,14616..14624)
/locus_tag="HO266_gp1"
/note="catalytic residues [active]"
/db_xref="CDD:394891"
misc_feature 14379..14468
/locus_tag="HO266_gp1"
/note="conserved polymerase motif B; other site"
/db_xref="CDD:394891"
misc_feature 14598..14642
/locus_tag="HO266_gp1"
/note="conserved polymerase motif C; other site"
/db_xref="CDD:394891"
misc_feature 14664..14729
/locus_tag="HO266_gp1"
/note="conserved polymerase motif D; other site"
/db_xref="CDD:394891"
misc_feature 14769..14804
/locus_tag="HO266_gp1"
/note="conserved polymerase motif E; other site"
/db_xref="CDD:394891"
misc_feature 15138..15422
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="Cys/His rich zinc-binding domain (CH/ZBD) of
coronavirus SARS NSP13 helicase and related proteins;
Region: ZBD_cv_Nsp13-like; cd21401"
/db_xref="CDD:439168"
misc_feature order(15270..15272,15333..15335,15339..15341,15378..15380,
15405..15419)
/locus_tag="HO266_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:439168"
misc_feature 15432..15572
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="stalk domain of coronavirus Nsp13 helicase and
related proteins; Region: stalk_CoV_Nsp13-like; cd21689"
/db_xref="CDD:410205"
misc_feature order(15441..15443,15528..15530)
/locus_tag="HO266_gp1"
/note="key interaction residues; other site"
/db_xref="CDD:410205"
misc_feature 15585..15818
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="1B domain of coronavirus SARS NSP13 helicase and
related proteins; Region: 1B_cv_Nsp13-like; cd21409"
/db_xref="CDD:394817"
misc_feature order(15669..15674,15678..15680,15771..15773)
/locus_tag="HO266_gp1"
/note="nucleic acid substrate binding site [nucleotide
binding]; other site"
/db_xref="CDD:394817"
misc_feature 15783..15791
/locus_tag="HO266_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:394817"
misc_feature 15888..16916
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="helicase domain of gammacoronavirus non-structural
protein 13; Region: gammaCoV_Nsp13-helicase; cd21720"
/db_xref="CDD:409653"
misc_feature order(15990..16007,16347..16349,16461..16463,16755..16757,
16761..16763,16842..16844)
/locus_tag="HO266_gp1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:409653"
misc_feature order(15999..16004,16257..16262,16347..16349,16842..16844)
/locus_tag="HO266_gp1"
/note="putative active site [active]"
/db_xref="CDD:409653"
misc_feature 16941..18494
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="nonstructural protein 14 of gammacoronavirus;
Region: gammaCoV_Nsp14; cd21658"
/db_xref="CDD:394957"
misc_feature order(16941..16943,16947..16958,16983..17012,17085..17087,
17097..17099,17112..17135,17235..17240,17304..17306,
17310..17312,17322..17327,17508..17510,17517..17522,
17529..17537,17580..17582)
/locus_tag="HO266_gp1"
/note="heterodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:394957"
misc_feature order(17202..17204,17208..17210,17505..17507,17733..17735,
17748..17750)
/locus_tag="HO266_gp1"
/note="ExoN active site [active]"
/db_xref="CDD:394957"
misc_feature order(17805..17807,17847..17849,17856..17861,17868..17870,
17928..17939,17943..17945,17985..17993,18018..18026,
18075..18089,18123..18125,18180..18182,18186..18191,
18198..18200,18204..18206,18435..18437)
/locus_tag="HO266_gp1"
/note="N7-MTase active site [active]"
/db_xref="CDD:394957"
misc_feature 18504..18683
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="N-terminal domain of gammacoronavirus Nonstructural
protein 15 (Nsp15), and related proteins; Region:
NTD_gammaCoV_Nsp15-like; cd22650"
/db_xref="CDD:439165"
misc_feature order(18504..18509,18561..18563,18567..18578,18600..18602,
18615..18617,18642..18644,18648..18659)
/locus_tag="HO266_gp1"
/note="putative hexamer interface [polypeptide binding];
other site"
/db_xref="CDD:439165"
misc_feature order(18525..18533,18537..18542,18579..18590,18594..18596,
18603..18605,18609..18626,18633..18644,18681..18683)
/locus_tag="HO266_gp1"
/note="putative trimer interface [polypeptide binding];
other site"
/db_xref="CDD:439165"
misc_feature 18693..19058
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="middle domain of gammacoronavirus Nonstructural
protein 15 (Nsp15), and related proteins; Region:
M_gcv_Nsp15-like; cd21168"
/db_xref="CDD:394906"
misc_feature 19053..19508
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="Nidoviral uridylate-specific endoribonuclease
(NendoU) domain of coronavirus Nonstructural protein 15
(Nsp15), arterivirus Nsp11, torovirus endoribonuclease,
Xenopus laevis endoribonuclease XendoU, and related
proteins; Region: NendoU_XendoU-like; cl41718"
/db_xref="CDD:455123"
misc_feature order(19167..19169,19179..19181,19203..19208,19212..19214,
19332..19334,19341..19346,19494..19496,19500..19502)
/locus_tag="HO266_gp1"
/note="putative active site [active]"
/db_xref="CDD:439156"
misc_feature 19515..20414
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="Coronavirus NSP13; Region: NSP13; pfam06460"
/db_xref="CDD:399456"
CDS 529..12480
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/codon_start=1
/product="ORF 1a polyprotein"
/protein_id="YP_009824997.1"
/db_xref="GeneID:55060244"
/translation="MASSLKQGVSPKLRDVILVSKDIPEQLCDALFFYTSHNPKDYAD
AFAVRHKFDRSLQTGKQFKFETVCGLFLLKGVDKITPGVPAKVLKSTSKLADLEDIFG
VSPFARKYRHLLKTACQWSLTVETLDARAQTLDEIFDPTEILWLQVAAKIQVSAMAMR
RLVGEVTAKVMEALGSNLSALFQIVKQQIARIFQKALAIFENVSELPQRIAALKMAFA
KCAKSITVVVVERTLIVKEFAGTCLASINGAVAKFFEELPNGFMGSKIFTTLAFFKEA
AVKIVENIPNAPRGTKGFEVVGNAKGTQVVVRGMRNDLTLLDQKVEIPVESEGWSAIL
EGHLCYVFKSGDRFYAAPLSGNFALHDVHCCERVVCLSDGVTPEINDGLILAAIYSSF
SVSELMAALKKGEPFKFLGHKFVYAKDAAVSFTLAKAATIADVLKLFQSARAKVEDVW
SSFTEKSFEFWKLAYGKVRILEDFVRPQLVRLKWSMGILATVLGEGIWHLVSQVIYKV
GGLFTKVVDFCEKYWKGFCAQLKRPKLIVTETLCVLKGVAQHCFQLLLDAIHSMYKSF
KKCALGRIHGDLLFWKGGVHKIIQEGDEIWFDAIDSIDVEDLGVVQEKSIDFEVCDNV
TLPENQPGHMVQIQNEDKNYMFFRFKKDENIYYTPMSQLGVINVVCKAGGKTVTFGET
TVQEIPPPDVVPIKVSIECCGEHGTQFSRKPIKEPIEVETDFTVEQLLSVIYEKMCDD
LKLFPEAPEPPPFEKVSLVEKQGKDLDCIKSCHWIYRDYESDDDIEEEDAEECDTDSG
DAEECDTNSECEEEDEDTKGLALIQDQPSYKYPLPLEEDYSVYNGCIVHKDALDVVNL
PSGEETFVVNDCFEGAVKPLPQKVIDVLGDWGEAVDAQEQLCQQESTQAAFERSVEDS
IGGCEAMAEQSVVDEHELLLVVEENQHGVVYTPADLEGVKETAEEVDEFILIADVSKE
EVVPQGKGESQVEQEPIQVVKSQREKKAKKFRVKPATCEKPKFLEYKTCVGDLTVVIA
KALDEFKEFCIVNAANEHMSHGGGVAKAIADFFGPDFVEYCEDYVKKHGPQQRLVTPS
FVKGIQCENNVVGLRHGDINSRQKLVAAYKNVLVDGVVNYAVPVLSLGIFGVDFKMSI
DAMREAFEGCTIRVLLFSLSQEHIDYFDVTCKQKTLYLTEDGVKYRSVVVKPGDSLSQ
FGQVFAKNKAVFTADDVEDKEILFVPTTDKTVLEYYPLDAQKYVIYLQTLAQKWNVQY
RDNFLILEWRDGNCWISSAIVLLQAAKIRFKGFLSEAWAKLLGGDPTDFVAWCYASCN
AKVGDFSDANWLLANFAEHFDADYKNAFLKKRVSCNCGVKSYELRGLEACIQPVRATN
LLHFKTQYSNCPTSGASNTDEVFEASLPYLLLFATDGPATVDCDEDAVGTVVFVGSTN
SVHCDTQAARQAFDNLAKDRKFGKKSPYKTAMYTRFAFKNENPLPVAKHSKGKSKSVK
EDVSNLATSSKASFDNLTDFEQWYTSNIYESLKVQESPYNFDKYVSFKIKEDSKLQKT
LKVRCIKSVFDFRSKDGFIYKLSPDTDENSKAPVYYPVLDSISLRAIWVEGSANFVVG
HPNYYSKFLHIPTFWENAENFVKMGDKIGGVSMGLWRAEHLNKPNLERIFNIAKKAIV
GSSVVTTQCGKLFGKAATFVADKVGDGVVRNITDSIKGLCGFTRGHFERKMSLQFLKT
LMFFLFYFLKASVKSVVSSYKIVLCKVVFVTLLIVWIVYTSNPVMFTGIRVLDFVFEG
SLCGPYKDYGKDSFDVLRNCAGDFTCRVCLHDRDSLHLFKYAYSVEQIYKDAASGINF
NWNWLYLVFLILFVKPVAGFVIICYCVKYLVLSSTVLQTGVGFLDWFVKTVFSHFNFM
GAGFYFWLFYKIYVQVHHILYCKDGTCGVCKRVARSTRQEVSVVVGGRQQIVHVYTNS
GYNFCKRHNWYCRNCDDYGHQNTFMSPEVAGELSEKLKRHVKPTAYAYPVVDEACLVD
DFVNLKYKAATPGKDNASSAVKCFSVTNFLKKAVFLKEALKCEQISNDGFIVCNTQSA
HALEEAKNAAVYYAQYLCKPILILDQALYEQLIVEPVSKSVVDKVCSILSNIISVDTA
ALNYKAGTLRDALLSITKDEEAVDMAIFCHNHEVEYTGDGFTNVIPSYGIDIDKLTPR
DRGFLINADASIANLRVKNAPPVVWKFSELIKLSDSCLKYLISATVKSGVRFFITKSG
VKQVIACHTQKLLVEKKAGGVISGTFKWFMSCFKWLLIFEILFTACCLGYYYLEVNKS
FVHPMYDVNSTLHFEGFQVIDNGVLRDIVPEDNCFSNKSVNFDAFWGKSYENNKNCPI
VTVVIDGHGTVAVGFPGFVSWVMDGVMFVHKTQTDRRPWYIPTWFNTDIVGYTQDSNI
TEDSFYTSIALFSARCLYLSASNTRQLYCFNRENDAPGALPFGSIIPHRVYFQPKGVR
LKVPQQILHTPYLVKLVSDSYCRGSVCEYTKPGYRVSLDPQWVLFNDEYTSKPGVFCG
STVRELMFNMVSTFFTGVNPNIYMQLATMFLILVVIVLIFAMVIKFQGVFKAYATIVF
TIMLVWVINAFVLCVHSYNSVLAVILLVLYCYASLVKSRNTGIIMHCGLVTMVGLIVP
TCLSCCFLGFILYMYTPLFFWCYGTTKNTRKLYDGNEFVGNYDLAAKSTFVIRGSEFV
KLTNEIGDKFEAYLSAYARLNYYSGTGSEQDYLQACRAWLAYALDQYRNSGVEIVYLP
PRYSIGVSRLQTGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDTIYCPRHVLGKFS
GDQWNDVLNLANNHEFEVTTQHGVTLNVVSRRLEGAVLILQTAVANAETPKYKFVKAN
CGDSFTIACSYGGTVVGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHL
ELPNALHTGTDLTGEFYGGLVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSQP
KWLESTTVSIEDYNKWASDNGLTPFSTSTAITKLCAISGIDVCKLLRTIMVESAQWGS
EPILGQYNFEDEYTPESVFNQIGGVRLQSSFVSKATSWFWSRCVLACFLFVLCAIVLF
TAVPLKFYVYAAVILLLAVFFISFTVKHVMAYMDTFLLPTLITVIIGVCAEVPFMYNT
LISQVVIFLSQWYDPVFFDTMVPWMLLPLVLYTAFKCVQGCYMNSFNTSLLMLYQFMK
FGFGIYTSSNTLTAYTEGNWELFFELVHTTVLANVSSNSLFGLFVFKCAKWMLYYCNA
TYLYNYVLLAVMVNCIGWLCTCYFGLYWWVNKVFGLSFGKYNFKVSVDQYRYMCLHKI
YPPKTVWEVFTTNILIQGIGGDRVFPISTVQSKLSDVKCTTVVLMQLLTKLNVEANSK
MHAYLVELHNKILASDDVGECMDNLLGMLITLFCIDSTIDLGEYCDDILKRSTVLQSV
TQEFSHIPSYAEYERAKSIYEKVLADSKNGGVTQQELAAYRNAANIAKSVFDRDLAVQ
KKLDSMAERAMTTMYKEARVTDRRAKLVSSLHALLFSMLKKIDSEKLNVLFDQANSGV
VPLATVPIVCSNKLTLVIPDPETWVKCVEVMHVTYSTVVWNIDCVTDADGTELHPTST
GSGLTYCISGDNIAWPLKVNLTRNGHNKVDVALQNNELMPHGVKTKACVAGVDQAHCS
VESKCYYTSISGSSVVAAITSSNSNLKVASFLNEAGNQIYVDLDPPCKFGMKVGDKVE
VVYLYLIKNTRSIVRGMVLGAISNVVVLQSKGHETEEVDAVGILSLCSFAVDPADTYC
KYVAAGNQPLGNCVKMLTVHNGSGFAITSKPSPTPDQDSYGGVSVCLYCRAHIAHPGG
AGNLDARCQFKGSFVQIPTTEKDPVGFCLRNKVCTVCQCWIGYGCQCDLLRQPKPSVQ
SVAVASDFDKNYLNRVRGGSAARLLPLAHGCGPMLYGEPLMFVIRNQPVCFKI"
misc_feature 568..1641
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="Replicase polyprotein 1a N-terminal domain; Region:
Nsp2a_N; pfam17896"
/db_xref="CDD:375411"
misc_feature 2608..2859
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="first ubiquitin-like (Ubl) domain located at the
N-terminus of coronavirus SARS-CoV non-structural protein
3 (Nsp3) and related proteins; Region:
Ubl1_cv_Nsp3_N-like; cl28922"
/db_xref="CDD:452900"
misc_feature 3640..4020
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="X-domain (or Mac1 domain) of viral non-structural
protein 3 and related macrodomains; Region:
Macro_X_Nsp3-like; cd21557"
/db_xref="CDD:438957"
misc_feature order(3658..3666,3676..3696,3919..3924,3928..3942,
4015..4017)
/locus_tag="HO266_gp1"
/note="ADP-ribose binding site [chemical binding]; other
site"
/db_xref="CDD:438957"
misc_feature 4054..4965
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus papain-like protease; Region:
gammaCoV_PLPro; cd21733"
/db_xref="CDD:409650"
misc_feature order(4264..4266,4339..4341,4348..4359,4504..4512,
4516..4521,4528..4533,4627..4632,4645..4647,4684..4692,
4696..4698,4759..4764,4768..4773,4819..4821,4840..4845,
4921..4923)
/locus_tag="HO266_gp1"
/note="ubiquitin binding site [polypeptide binding]; other
site"
/db_xref="CDD:409650"
misc_feature order(4504..4512,4771..4776,4819..4821,4828..4830,
4846..4848,4921..4923)
/locus_tag="HO266_gp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:409650"
misc_feature 5755..7329
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="C-terminus of gammacoronavirus non-structural
protein 3, including transmembrane and Y domains; Region:
TM_Y_gammaCoV_Nsp3_C; cd21710"
/db_xref="CDD:409658"
misc_feature 5755..5820
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="TM1 [structural motif]; Region: TM1"
/db_xref="CDD:409658"
misc_feature 6064..6132
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="TM2 [structural motif]; Region: TM2"
/db_xref="CDD:409658"
misc_feature 7369..8550
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="coronavirus non-structural protein 4 (Nsp4)
transmembrane domain; Region: cv_Nsp4_TM; cd21473"
/db_xref="CDD:394836"
misc_feature 7369..7437
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="putative TM helix 1 [structural motif]; Region:
putative TM helix 1"
/db_xref="CDD:394836"
misc_feature 8206..8271
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="putative TM helix 2 [structural motif]; Region:
putative TM helix 2"
/db_xref="CDD:394836"
misc_feature 8314..8379
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="putative TM helix 3 [structural motif]; Region:
putative TM helix 3"
/db_xref="CDD:394836"
misc_feature 8458..8526
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="putative TM helix 4 [structural motif]; Region:
putative TM helix 4"
/db_xref="CDD:394836"
misc_feature 8593..8862
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="Coronavirus nonstructural protein 4 C-terminus;
Region: Corona_NSP4_C; pfam16348"
/db_xref="CDD:406690"
misc_feature 8875..9792
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 5, also
called Main protease (Mpro); Region: gammaCoV_Nsp5_Mpro;
cd21667"
/db_xref="CDD:394888"
misc_feature order(8875..8877,8881..8883,8887..8904,8911..8913,
9229..9246,9274..9288,9361..9375,9721..9723,9727..9732,
9766..9771)
/locus_tag="HO266_gp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:394888"
misc_feature order(8944..8952,8992..8994,9283..9300,9352..9363,
9379..9381,9424..9441)
/locus_tag="HO266_gp1"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:394888"
misc_feature 9754..10671
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 6; Region:
gammaCoV-Nsp6; cd21559"
/db_xref="CDD:394845"
misc_feature 10672..10920
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 7; Region:
gammaCoV_Nsp7; cd21828"
/db_xref="CDD:409254"
misc_feature order(10675..10677,10684..10695,10702..10710,10714..10719,
10726..10728,10753..10755,10762..10764,10780..10782,
10816..10833,10837..10854,10873..10887)
/locus_tag="HO266_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409254"
misc_feature 10921..11550
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 8; Region:
gammaCoV_Nsp8; cd21832"
/db_xref="CDD:409259"
misc_feature order(10930..10938,10945..10950,10954..10959,10969..10971,
10987..10992,11122..11124,11131..11133,11140..11145,
11167..11172,11179..11184,11188..11196,11200..11208,
11212..11232,11236..11244,11248..11253,11260..11265,
11269..11271,11275..11280,11287..11298,11377..11379)
/locus_tag="HO266_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409259"
misc_feature 11545..11883
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 9; Region:
gammaCoV_Nsp9; cd21899"
/db_xref="CDD:409332"
misc_feature 11551..11568
/locus_tag="HO266_gp1"
/note="N-finger; other site"
/db_xref="CDD:409332"
misc_feature order(11557..11565,11569..11574,11761..11769,11812..11814,
11830..11835,11839..11847,11851..11859,11863..11868)
/locus_tag="HO266_gp1"
/note="homodimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409332"
misc_feature 11887..12288
/locus_tag="HO266_gp1"
/old_locus_tag="IBVgp1"
/note="gammacoronavirus non-structural protein 10; Region:
gammaCoV_Nsp10; cd21902"
/db_xref="CDD:409327"
misc_feature order(11887..11910,11920..11922,11926..11934,11938..11946,
11959..11964,11971..11976,11983..11985,12004..12021,
12058..12063,12091..12093,12097..12102,12112..12114,
12118..12135,12160..12168,12175..12186)
/locus_tag="HO266_gp1"
/note="Nsp14 interface [polypeptide binding]; other site"
/db_xref="CDD:409327"
misc_feature order(11926..11934,11938..11946,11959..11961,12004..12006,
12010..12021,12058..12066,12118..12129,12136..12138,
12181..12186,12238..12240)
/locus_tag="HO266_gp1"
/note="oligomer interface [polypeptide binding]; other
site"
/db_xref="CDD:409327"
misc_feature order(11959..11961,12010..12021,12058..12066,12136..12138,
12181..12186,12238..12240)
/locus_tag="HO266_gp1"
/note="homotrimer interface [polypeptide binding]; other
site"
/db_xref="CDD:409327"
misc_feature order(12004..12027,12058..12063,12091..12102,12115..12120,
12124..12126,12175..12186)
/locus_tag="HO266_gp1"
/note="Nsp16 interface [polypeptide binding]; other site"
/db_xref="CDD:409327"
gene 20374..23835
/gene="S"
/locus_tag="HO266_gp2"
/old_locus_tag="IBVgp2"
/db_xref="GeneID:55060242"
CDS 20374..23835
/gene="S"
/locus_tag="HO266_gp2"
/old_locus_tag="IBVgp2"
/note="surface protein"
/codon_start=1
/product="spike glycoprotein"
/protein_id="YP_009824998.1"
/db_xref="GeneID:55060242"
/translation="MLVTPLLLVTLLCVLCSAALYDSSSYVYYYQSAFRPPNGWHLHG
GAYAVVNISSESNNAGSSSGCTVGTIHGARVVNASSIAMTAPSSGMAWSSSQFCTAHC
NFSDTTVFVTHCYKYDGCPITGMLQQNLLRVSAMKNGQLFYNLTVSVAKYPTCKSFQC
VNNFTSVYLNGDLVYTSNETTDVTSAGVYFNAGGPITYKVMREVKALAYFVNGTAQDV
ILCGGSPRGLLACQYNTGNFSDGFYPFINSSLVKQKFIVYRENSVNTTFTLHYFSFHN
ETGANPNPSGVQNIQIYQTQTAQSGYYNFNFSFLSSFVYKESNFMYGSYHPSCIFRLE
TINNGWGFNSLSVSFAYGPLQGGCKQSVFSGRATCCYAYSYGGPSLCKGVYLGELKSD
FECGLLVYVTKSDGSRIQTATQPPVITQHIYKNITLNTCVDYNIYGRTGQGFITNVTD
SAVSYNYLADAGLAILDTSGSIDIFVVQGEYGLTYYKVNPCEDVNQQFVVSGGQLVGI
LTSRNEPGTQLLENQFYIKITNGTRRFRRSITEKVANCPYVSYGKFCIKPDGSIATIV
PKQLEQFVAPLLNVTENVLIPNSFNLTVTDEYIQTRMDKVQINCLQYVCGNSLDCREL
FQQYGPVCDNILSVVNSVGKKEDMELLNFYSSTKPAGFNTPVLSNVSTGEFNISLLLT
TPSSPRRRSFIEDLLFTSVESVGLPTDDAYKNCTAGPLGFLKDLACAREYNGLLVLPP
IITAEMQTLYTSSLVASMAFGGITAAGAIPFATQLQARINHLGITQSLLLKNQEKIAA
SFNKAIGRMQEGFRSTSLALQQIQDVVNKQSAILTETMASLIKNFGAISTMIQEIYQQ
FDAIQANAQVDRLITGRLSSLSVLASAKQAEHIRVSQQRELATQKINECVKSQSNRYS
FCGNGRHVLTIPQNAPNGIVFIHFSYTPDSFVNVTAIVGFCVKPANASQYAIVPVNGR
GIFIQVNGSYYITARDMYMPRAITAGDIVTLTSCQANYVSVNKTVITTFVDNDDFDFN
DELSKWWNATKHELPDFDKFNYTVPILDIDSEIDRIQGVIQGLNDSSIDLEKLSILKT
YIKWPWYVWLAIAFATIIFILILGWVFFMTGCCGCCCGCLGIMPLMRKCGKKSSYYTT
FDNDVVT"
misc_feature 21640..23622
/gene="S"
/locus_tag="HO266_gp2"
/old_locus_tag="IBVgp2"
/note="SD-1 and SD-2 subdomains, the S1/S2 cleavage
region, and the S2 fusion subunit of the spike (S)
glycoprotein from avian infectious bronchitis coronavirus
(IBV) and related gammacoronaviruses; Region:
gammaCoV_Spike_SD1-2_S1-S2_S2; cd22372"
/db_xref="CDD:411959"
misc_feature 22039..22116
/gene="S"
/locus_tag="HO266_gp2"
/note="S1/S2 cleavage region; other site"
/db_xref="CDD:411959"
misc_feature 22366..22416
/gene="S"
/locus_tag="HO266_gp2"
/note="fusion peptide; other site"
/db_xref="CDD:411959"
misc_feature 22444..22497
/gene="S"
/locus_tag="HO266_gp2"
/note="internal fusion peptide (IFP); other site"
/db_xref="CDD:411959"
misc_feature 22744..22941
/gene="S"
/locus_tag="HO266_gp2"
/old_locus_tag="IBVgp2"
/note="heptad repeat 1 [structural motif]; Region: heptad
repeat 1"
/db_xref="CDD:411959"
misc_feature 23506..23622
/gene="S"
/locus_tag="HO266_gp2"
/old_locus_tag="IBVgp2"
/note="heptad repeat 2 [structural motif]; Region: heptad
repeat 2"
/db_xref="CDD:411959"
gene 23862..24539
/gene="3"
/locus_tag="HO266_gp3"
/old_locus_tag="IBVgp3"
/db_xref="GeneID:55060241"
CDS 23862..24035
/gene="3"
/locus_tag="HO266_gp3"
/old_locus_tag="IBVgp3"
/codon_start=1
/product="3a protein"
/protein_id="YP_009824999.1"
/db_xref="GeneID:55060241"
/translation="MIQSPTSFLIVLIFLWCKLVLSCFREFIIALQQLIQVLLQIINS
NLQPSLTLCHSLD"
misc_feature 23862..24032
/gene="3"
/locus_tag="HO266_gp3"
/old_locus_tag="IBVgp3"
/note="IBV 3A protein; Region: IBV_3A; pfam03617"
/db_xref="CDD:281600"
CDS 24035..24229
/gene="3"
/locus_tag="HO266_gp3"
/old_locus_tag="IBVgp3"
/codon_start=1
/product="3b protein"
/protein_id="YP_009825000.1"
/db_xref="GeneID:55060241"
/translation="MLNLEAIFETGEQEIQKISFNLQHISRVLTTEVFDPFDYCYYRG
GNFWEIESAEDCSGDDEFIE"
misc_feature 24035..24226
/gene="3"
/locus_tag="HO266_gp3"
/old_locus_tag="IBVgp3"
/note="IBV 3B protein; Region: IBV_3B; pfam03622"
/db_xref="CDD:281605"
CDS 24210..24539
/gene="3"
/locus_tag="HO266_gp3"
/old_locus_tag="IBVgp3"
/note="E; small membrane protein; envelope protein"
/codon_start=1
/product="3c protein"
/protein_id="YP_009825001.1"
/db_xref="GeneID:55060241"
/translation="MMNLLNKSLEENGSFLTALYIIVGFLALYLLGRALQAFVQAADA
CCLFWYTWVVIPGAKGTAFVYKYTYGRKLNNPELEAVIVNEFPKNGWNNKNPANFQDV
QRDKLHS"
misc_feature 24213..24488
/gene="3"
/locus_tag="HO266_gp3"
/old_locus_tag="IBVgp3"
/note="IBV 3C protein; Region: IBV_3C; pfam03620"
/db_xref="CDD:281603"
gene 24511..25188
/gene="4"
/locus_tag="HO266_gp4"
/old_locus_tag="IBVgp4"
/db_xref="GeneID:55060243"
CDS 24511..25188
/gene="4"
/locus_tag="HO266_gp4"
/old_locus_tag="IBVgp4"
/note="M"
/codon_start=1
/product="membrane glycoprotein"
/protein_id="YP_009825002.1"
/db_xref="GeneID:55060243"
/translation="MSNETNCTLDFEQSVELFKEYNLFITAFLLFLTIILQYGYATRS
KFIYILKMVVLWCFWPLNIAVGVISCIYPPNTGGLVAAIILTVFACLSFVGYWIQSIR
LFKRCRSWWSFNPESNAVGSILLTNGQQCNFAIESVPMVLSPIIKNGVLYCEGQWLAK
CEPDHLPKDIFVCTPDRRNIYRMVQKYTGDQSGNKKRFATFVYAKQSVDTGELESVAA
GGGSLYT"
misc_feature 24529..25161
/gene="4"
/locus_tag="HO266_gp4"
/old_locus_tag="IBVgp4"
/note="gammacoronavirus Membrane (or Matrix) protein;
Region: gammaCoV_M; cd21566"
/db_xref="CDD:394852"
gene 25539..25981
/gene="5"
/locus_tag="HO266_gp5"
/old_locus_tag="IBVgp5"
/db_xref="GeneID:55060240"
CDS 25539..25736
/gene="5"
/locus_tag="HO266_gp5"
/old_locus_tag="IBVgp5"
/codon_start=1
/product="5a protein"
/protein_id="YP_009825003.1"
/db_xref="GeneID:55060240"
/translation="MKWLTSFVRAVISCYKPLLLTQLRVLEKLILDHGTNHILTCIRR
VILFQLDLVYRLAYTPTQSLV"
misc_feature 25539..25730
/gene="5"
/locus_tag="HO266_gp5"
/old_locus_tag="IBVgp5"
/note="Coronavirus 5a protein; Region: Corona_5a;
pfam06336"
/db_xref="CDD:283895"
CDS 25733..25981
/gene="5"
/locus_tag="HO266_gp5"
/old_locus_tag="IBVgp5"
/codon_start=1
/product="5b protein"
/protein_id="YP_009825004.1"
/db_xref="GeneID:55060240"
/translation="MNNSKDNPFRGAIARKARIYLREGLDCVYFLNKAGQAESCPACT
SLVFQGKTCEEHKYNNNLLSWQAVRQLERQTPQRQSSN"
misc_feature 25733..25978
/gene="5"
/locus_tag="HO266_gp5"
/old_locus_tag="IBVgp5"
/note="Coronavirus gene 5 protein; Region: Coronavirus_5;
pfam05528"
/db_xref="CDD:283238"
gene 25924..27153
/gene="6"
/locus_tag="HO266_gp6"
/old_locus_tag="IBVgp6"
/db_xref="GeneID:55060239"
CDS 25924..27153
/gene="6"
/locus_tag="HO266_gp6"
/old_locus_tag="IBVgp6"
/codon_start=1
/product="nucleocapsid protein"
/protein_id="YP_009825005.1"
/db_xref="GeneID:55060239"
/translation="MASGKATGKTDAPAPVIKLGGPKPPKVGSSGNVSWFQAIKAKKL
NTPPPKFEGSGVPDNENIKPSQQHGYWKRQARFKPGKGGRKPVPDAWYFYYTGTGPAA
DLNWGDTQDGIVWVAAKGADTKFRSNQGTSDSDKFDQYPLRFSDGGPDGNFRWDFFPL
NRGRSGRSTAASSAASSRAPSREVSRGRRSGSEDDLIARAARIIQDQQKKGSRITKAK
ADEMAHRRYCKRTIPPNYKVDQVFGPRTKGKEGNFGDDKMNEEGIKDGRVTAMLNLVP
SSHACLFGSRVTPRLQPDGLHFKFEFTTVVPRDDPQFDNYVKICDQCVDGVGTRPKDD
EPRPKSRSSSRPATRGNSPAPRQQRPKKEKKPKKQDDEVDKALTSDEERNNAQLEFDD
EPKVINWGDSALGENEL"
misc_feature 25987..26982
/gene="6"
/locus_tag="HO266_gp6"
/old_locus_tag="IBVgp6"
/note="N-terminal domain of nucleocapsid (N) protein of
coronavirus; Region: CoV_N-NTD; cl41918"
/db_xref="CDD:455263"
misc_feature order(26014..26037,26191..26193,26197..26199,26203..26205,
26317..26319,26338..26340)
/gene="6"
/locus_tag="HO266_gp6"
/note="RNA binding site [nucleotide binding]; other site"
/db_xref="CDD:439219"
ORIGIN
1 acttaagata gatattaata tatatctatc acactagcct tgcgctagat ttccaactta
61 acaaaacgga cttaaatacc tacagctggt cctcataggt gttccattgc agtgcacttt
121 agtgccctgg atggcacctg gccacctgtc aggtttttgt tattaaaatc ttattgttgc
181 tggtatcact gcttgttttg ccgtgtctca ctttatacat ccgttgcttg ggctacctag
241 tatccagcgt cctacgggcg ccgtggctgg ttcgagtgcg aagaacctct ggttcatcta
301 gcggtaggcg ggtgtgtgga agtagcactt cagacgtacc ggttctgttg tgtgaaatac
361 ggggtcacct ccccccacat acctctaagg gcttttgagc ctagcgtagg gctacgttct
421 cgcataaggt cggctatacg acgtttgtag ggggtagtgc caaacaaccc ctgaggtgac
481 aggttctggt ggtgtttagt gagcagacat acaatagaca gtgacaacat ggcttcaagc
541 ctaaaacagg gagtatctcc caaactaagg gatgtcattc ttgtatccaa agacattcct
601 gaacaacttt gtgacgcttt gtttttctat acgtcacaca accctaagga ttacgctgat
661 gcttttgcag ttaggcacaa gtttgaccgt agtctgcaga ctgggaaaca gttcaaattt
721 gaaactgtgt gtggtctctt cctcttgaag ggagttgaca aaataacacc tggtgtccca
781 gcaaaggttt taaaatccac ttctaagttg gcagatttag aagacatctt tggtgtctct
841 ccatttgcac ggaagtaccg tcatttgttg aaaacagcat gccagtggtc tcttactgta
901 gagacactgg atgctcgtgc acaaactctt gatgaaattt ttgaccctac tgaaatactt
961 tggcttcagg tggctgcaaa aattcaagtt tcagctatgg caatgcgcag gcttgttgga
1021 gaagtaactg caaaagtcat ggaagctctt ggctcaaatc tgagtgctct ctttcaaatt
1081 gttaaacaac aaatagccag aatctttcaa aaggcactgg ctatttttga aaatgtgagt
1141 gaattaccac agcgtattgc agcacttaag atggcctttg ccaagtgtgc taagtcaatt
1201 actgttgtgg ttgtggaaag aactctaatt gttaaagagt tcgcaggaac ttgtcttgca
1261 agcattaatg gtgctgttgc aaaattcttt gaagaacttc caaatggttt tatgggttct
1321 aaaatcttca caacattggc cttctttaaa gaagcagctg tgaaaattgt ggaaaatata
1381 ccaaatgcac caagaggcac taagggtttt gaagttgttg gcaatgccaa aggtacacaa
1441 gttgttgtgc gtggcatgcg aaatgaccta acattgcttg accaaaaagt tgaaattcct
1501 gttgagtcag aaggttggtc tgcaatttta gaaggacatc tctgttatgt ctttaagagt
1561 ggtgatcgtt tttatgcggc acctctttct ggaaattttg cgttgcatga tgtgcattgt
1621 tgtgagcgtg ttgtttgtct atctgatggt gtaacaccgg agataaatga tggactcatt
1681 ctcgctgcaa tttactcatc ttttagtgtc tcagaactca tggcagccct taaaaagggt
1741 gaaccattta agtttttggg ccataaattt gtgtatgcaa aggatgcagc agtgtctttt
1801 actttagcga aggctgccac tattgcagat gttttgaagc tgtttcaatc agcgcgtgcg
1861 aaagtcgaag atgtttggtc ttcatttact gaaaagtctt ttgaattctg gaagcttgca
1921 tatggaaaag tgcgcatcct tgaagacttt gtgagacctc agcttgtaag gctcaaatgg
1981 tcaatgggga ttctggcgac agtgcttgga gagggcattt ggcatcttgt ttcacaagtc
2041 atctataaag taggtggtct ttttactaaa gttgttgact tctgtgagaa atattggaaa
2101 ggtttttgtg cacagttgaa aaggcctaag ctcattgtca ctgaaaccct ctgtgtttta
2161 aaaggagttg cacagcattg ttttcaactg ttgctggatg caatacattc tatgtataag
2221 agttttaaga agtgtgcact tggtagaatt catggagatt tgctcttctg gaaaggaggt
2281 gtgcacaaaa ttattcaaga gggcgatgaa atttggtttg acgccattga tagcattgat
2341 gttgaagatc tgggtgttgt tcaagaaaaa tcgattgatt ttgaggtttg cgataatgtg
2401 acacttccag aaaaccaacc tggtcatatg gttcaaatcc agaatgagga taagaactat
2461 atgttcttcc gttttaaaaa ggatgagaac atttattata caccaatgtc tcaacttggt
2521 gtaattaatg tagtttgcaa agccggcggt aaaaccgtca cctttggaga aactactgtg
2581 caagaaatac caccacctga tgttgtgcct attaaggtta gcatcgagtg ttgtggtgaa
2641 catggaacac aattttcaag aaagcctatt aaagagccca ttgaagttga gacggacttc
2701 acagttgaac aattgctctc tgtgatctat gagaaaatgt gtgacgacct caagttgttt
2761 ccagaggcac ccgagcctcc accatttgag aaagtttcac ttgttgaaaa gcagggtaaa
2821 gatttggatt gtataaaatc ttgccattgg atctatcgtg actatgagag cgatgatgac
2881 atcgaggaag aagatgcaga agaatgtgac acggattcag gtgatgctga ggagtgtgac
2941 actaattcag aatgtgaaga agaagatgag gatactaaag ggttggccct tatacaagac
3001 cagccaagtt ataaataccc tcttccactg gaagaagatt atagcgtcta caatggatgt
3061 attgttcata aagacgctct tgatgttgtg aatctaccat ctggtgaaga aacttttgtt
3121 gttaatgact gttttgaggg agctgtaaaa ccgcttccgc agaaagttat tgatgttctt
3181 ggtgactggg gtgaggctgt tgatgcgcaa gaacaattgt gtcaacaaga atctactcaa
3241 gccgcatttg agagatcagt tgaggattct attggtggtt gtgaggcaat ggctgaacaa
3301 tctgtcgttg acgagcatga attattactt gtagttgaag aaaatcagca tggggttgtt
3361 tatacacctg ccgatctaga aggtgtaaaa gaaacagcag aagaggttga tgaatttatt
3421 ctcattgctg atgtttccaa agaagaagtt gtgcctcaag ggaaagggga gtcacaagtt
3481 gagcaagagc ctattcaagt tgttaaatca caacgtgaga agaaggctaa aaaattcaga
3541 gttaaaccag ccacatgcga aaaacccaaa tttttggagt ataaaacctg tgtgggtgat
3601 ttaactgttg taattgccaa ggcattggac gagtttaaag agttctgtat tgtaaacgcc
3661 gcgaatgagc atatgtctca tggtggtggc gttgcaaagg caattgcaga cttttttgga
3721 cctgattttg tggaatattg tgaggactat gttaaaaaac atgggccgca acagagactt
3781 gtcacacctt cgtttgttaa aggcattcaa tgtgagaata atgttgtggg actacgccat
3841 ggagacatta attcgcgtca gaagcttgtt gctgcataca agaatgtgct tgtagatggc
3901 gtagtcaatt atgctgtgcc agttctttca ttaggaattt ttggtgtgga ttttaaaatg
3961 tcaatagacg caatgcgtga agcctttgaa ggttgcacca tacgcgttct tttgttctct
4021 ctgagtcaag aacacatcga ttatttcgat gtaacttgca agcagaagac actctatctt
4081 acggaggatg gtgttaaata ccgctccgtt gttgtaaaac ctggtgactc attgagtcaa
4141 tttggacagg tttttgctaa aaataaggca gtctttacag ctgatgatgt tgaggataaa
4201 gaaatcctct tcgtacccac tactgacaag actgttcttg aatattatcc tttagatgcg
4261 caaaagtatg taatatattt gcaaacgctt gcgcagaaat ggaatgtcca atatagggac
4321 aattttctta tactagagtg gcgtgatgga aactgctgga ttagttcagc aattgttctc
4381 cttcaagctg ctaaaattag gtttaaaggt tttctatcag aagcatgggc taaactgttg
4441 ggtggagatc ctacagactt tgttgcctgg tgttatgcaa gttgcaatgc taaagttggt
4501 gatttttcag atgctaattg gcttttggcc aattttgcag aacattttga cgcagattac
4561 aaaaatgcct ttcttaagaa gcgcgtttcg tgcaactgtg gtgttaaaag ttatgagctt
4621 aggggccttg aagcttgtat tcagccagtt cgggcaacta atctgctaca ttttaaaacg
4681 caatattcaa attgcccaac cagtggggca agtaatacgg atgaagtatt tgaagcttcg
4741 ttaccgtact tattgctttt tgctactgat ggtcctgcta cagttgattg tgatgaagat
4801 gcagtgggga ctgtcgtgtt tgttggttct actaatagtg tccattgtga tacacaagct
4861 gcacggcaag cttttgataa tcttgctaaa gatagaaaat ttggaaagaa gtcgccttac
4921 aagactgcaa tgtatacgcg attcgctttt aagaatgaaa atcctttgcc tgttgctaaa
4981 catagtaagg gtaagtctaa gtcggtaaag gaagatgttt ctaaccttgc tactagttct
5041 aaggccagtt ttgataatct tactgacttc gaacagtggt atactagtaa catctatgaa
5101 agtcttaaag tgcaggaatc accatataac tttgataaat atgtgtcatt caaaataaag
5161 gaagattcta agttgcaaaa gacacttaag gttagatgta ttaaatcagt ttttgacttt
5221 agatcgaagg atggttttat ttataagtta tctcctgata ctgatgaaaa ttcaaaagca
5281 ccagtctact acccagtctt ggattctatt agtcttaggg caatatgggt ggaaggcagt
5341 gctaattttg ttgttgggca tccaaattat tatagtaagt ttctccatat tcctactttt
5401 tgggaaaatg cagagaattt tgttaaaatg ggtgataaaa ttggtggtgt atctatggga
5461 ctttggcgtg cagaacacct taataaacct aacttggaga gaattttcaa cattgctaag
5521 aaagccattg ttggatctag tgttgttact acacaatgcg gtaaattatt tggtaaagca
5581 gctacattcg ttgccgataa agtaggtgat ggtgtagttc gcaatattac agatagcatt
5641 aagggtcttt gtggattcac acgtggccat tttgaaagaa aaatgtccct acaattccta
5701 aagacgctta tgttcttttt attctatttc ttgaaggcta gtgttaagag tgttgtttct
5761 agctataaga ttgtgttatg taaggtggtg tttgttactt tacttatagt ttggattgtc
5821 tacacaagta acccagtaat gtttacagga atacgtgtgt tagattttgt attcgagggt
5881 tctttgtgtg gtccttataa agactatggt aaagattctt ttgatgtgtt acgcaattgt
5941 gcaggtgatt ttacttgtcg tgtgtgttta catgacagag attcacttca tctgttcaaa
6001 tatgcttata gcgtagagca gatttataag gatgcagctt ctggcattaa ctttaattgg
6061 aattggcttt atttggtctt tctaatatta tttgttaagc cagtggcagg ttttgttatt
6121 atttgttatt gtgttaagta tttggtattg agttcaactg tgttgcaaac tggtgtaggt
6181 tttttagatt ggtttgtaaa aacagttttt agtcacttta attttatggg cgcagggttt
6241 tatttctggc tattttacaa gatatacgta caggtgcatc atatactgta ttgtaaggat
6301 ggaacatgtg gagtgtgcaa gagagttgca cgcagcacca ggcaagaggt tagcgttgtt
6361 gttggtggac gccagcaaat agtgcatgtt tacactaatt ctggctataa cttttgtaaa
6421 agacataatt ggtattgtag aaattgtgat gattatggtc accaaaatac atttatgtcc
6481 cctgaagttg ctggcgagct ttctgaaaag cttaagcgcc atgttaaacc tacagcatat
6541 gcttaccccg ttgtggatga ggcatgcttg gtggatgatt ttgttaattt aaaatataaa
6601 gctgcaactc ctggtaagga taatgcatct tctgctgtta agtgtttcag tgttacaaat
6661 ttcttaaaga aagctgtttt tcttaaggag gcattgaaat gtgaacaaat atctaatgat
6721 ggttttatag tgtgtaatac acagagtgcg catgcattag aggaagcaaa gaatgcagcc
6781 gtctattatg cgcaatatct gtgtaagcca atacttatac ttgaccaggc actttatgag
6841 caattaatag tagagcctgt gtctaagagt gttgtagata aagtgtgtag cattttgtct
6901 aatataatat ctgtagatac tgcagcttta aattataagg caggcacact tcgtgatgct
6961 ctgctttcta ttactaaaga cgaagaagcc gtagatatgg ctatcttttg ccacaatcat
7021 gaagtggaat acactggtga tggttttact aacgtgatac cgtcatatgg tattgatatt
7081 gataagttga cacctcgtga tagagggttt ttgataaatg cagatgcttc tattgctaac
7141 ttaagagtaa aaaatgctcc gccggtagta tggaagtttt ctgagcttat taagttgtct
7201 gacagttgcc ttaaatattt aatttcagct actgtcaagt caggtgttcg tttctttata
7261 acaaagtctg gtgttaaaca agttattgct tgtcatacac agaagttgtt ggtagagaaa
7321 aaggcaggtg gtgttattag cggcaccttt aagtggttta tgagttgttt taaatggctt
7381 ttgatctttg aaatactttt taccgcatgt tgtttgggtt attactattt ggaggtgaat
7441 aaaagttttg ttcaccccat gtatgatgta aactctacac tgcattttga aggttttcaa
7501 gttatagata acggtgttct tagggatatt gtaccagaag ataattgttt ctctaataag
7561 tctgttaatt ttgacgcctt ttggggtaaa tcatatgaaa ataataaaaa ctgtccaatt
7621 gttacagttg ttattgatgg tcatgggaca gttgctgttg gttttcctgg ttttgtatca
7681 tgggttatgg atggtgttat gtttgtgcat aagacacaga ctgatcggag accttggtac
7741 attcctactt ggtttaatac agatattgtt ggttacactc aggattcaaa tatcactgag
7801 gatagttttt atacatctat tgcattattt tctgctagat gtttatattt atcagccagc
7861 aatacacgtc aattgtattg ttttaatcgc gagaatgatg cacctggagc cttaccattt
7921 ggtagtatta ttcctcatag agtatacttc caacctaagg gtgtaaggct taaagttccc
7981 caacaaatac tgcatacacc ctacctagta aagttggttt ccgacagcta ttgtaggggt
8041 agtgtgtgtg agtacactaa accaggttac cgtgtgtcac tagacccaca atgggttttg
8101 tttaatgatg aatacactag taaacctggc gttttctgtg gttctactgt tagagaactt
8161 atgtttaata tggttagtac attctttact ggtgtcaacc ctaatattta tatgcaatta
8221 gcaactatgt ttttaatact agttgttatt gtgttaattt ttgcaatggt tataaagttt
8281 caaggtgttt ttaaagctta tgcgactatt gtgtttacaa taatgttagt ttgggttatt
8341 aatgcatttg ttttgtgtgt acatagttat aacagtgttt tagctgttat attactagta
8401 ctttattgct atgcgtcatt ggttaaaagt cggaatactg gcataattat gcattgtggg
8461 cttgtcacta tggttggctt aatagtaccc acatgcttgt cttgctgctt cctgggattc
8521 attctttata tgtacacacc gttgtttttc tggtgttatg gtactactaa aaacactcgt
8581 aagttgtatg atggcaatga gtttgttggt aattatgacc ttgctgcgaa gagcactttt
8641 gttattcgtg gctctgaatt tgttaagctt acaaatgaga ttggtgataa atttgaggcc
8701 tatctttctg cgtatgctag attaaattac tattcaggca ctggcagtga gcaagattat
8761 ttgcaagctt gtcgtgcatg gttagcttat gctttggacc aatatagaaa tagtggtgtt
8821 gagattgttt atctcccacc ccgttactct attggtgtta gtagattaca aactggtttt
8881 aaaaaacttg tttctcctag tagtgctgtt gaaaagtgca ttgttagtgt ctcttataga
8941 ggtaataatc ttaatggact gtggcttggt gacactatct actgtcctcg tcatgtattg
9001 ggtaagtttt caggtgacca atggaatgat gtacttaatc ttgctaataa tcatgagttt
9061 gaagttacaa ctcaacatgg tgttactttg aatgttgtca gtaggcgttt agaaggtgca
9121 gttttaattt tacaaactgc agttgccaat gctgaaactc ctaagtataa gtttgttaaa
9181 gctaattgtg gtgatagttt cactatagct tgttcttatg gtggtacagt tgtaggactt
9241 taccctgtca ctatgcgttc taatggtact attagagcat cttttcttgc gggagcctgt
9301 ggctcagttg gttttaatat agaaaagggt gtagttaatt tcttttatat gcaccatctt
9361 gagttaccta atgcattaca cactggaact gacctaacgg gggagtttta tggtggttta
9421 gtagatgaag aggttgcgca aagagtgcca ccagataatt tagttactaa caatattgta
9481 gcatggctct atgcggcaat tattagtgtt aaggaaagta gcttttcaca acctaaatgg
9541 ttggagagta ctactgtttc tattgaagat tacaataagt gggctagtga caatggtctt
9601 actccatttt ccactagtac tgctattact aaattatgtg ctatatctgg gattgatgtt
9661 tgtaaacttc ttcgcactat tatggtagaa agtgctcaat ggggtagtga acccattctt
9721 ggccaatata atttcgaaga tgaatacaca ccagagtctg tttttaacca gattggtggt
9781 gttagattac agtcttcttt tgtatcaaaa gctacatctt ggttttggag tagatgtgtg
9841 ttagcttgct tcttatttgt gttgtgtgct attgtcttgt ttacggcagt gccacttaaa
9901 ttttatgtat atgcagctgt tattttgtta ttggctgtat tttttatttc ttttactgtt
9961 aaacatgtta tggcatatat ggatactttt ctattgccaa cattgattac agttattatt
10021 ggagtttgtg ctgaagtgcc tttcatgtac aatactctaa ttagtcaagt tgttattttc
10081 ttaagccaat ggtatgaccc tgtattcttt gatactatgg taccatggat gttattgcca
10141 ttagtgttgt acacagcttt taagtgtgta caaggttgct atatgaattc tttcaatact
10201 tctttgttaa tgctgtatca gtttatgaag tttggttttg gtatttacac ctcttcaaac
10261 actcttactg catacacaga aggtaattgg gagttattct tcgagttggt gcacactact
10321 gtgttggcta atgttagtag taattcttta tttggtttat ttgtttttaa gtgtgctaaa
10381 tggatgttgt attattgtaa tgcaacatac ttatacaatt atgtactatt ggcagttatg
10441 gttaactgca ttggctggct ctgcacttgt tactttgggt tgtattggtg ggttaataag
10501 gtttttggtt tatcctttgg taaatacaat tttaaagttt cagttgatca atataggtat
10561 atgtgtttgc acaagatata cccacctaaa actgtgtggg aagtctttac tacaaatata
10621 cttatacaag gaattggagg cgatcgtgtg tttcctatat ctacagttca atctaaattg
10681 agtgatgtaa agtgtacaac tgttgtttta atgcagctct tgactaagct taatgttgaa
10741 gcaaattcaa aaatgcatgc ttatcttgtt gagttacaca ataaaatcct cgcatctgat
10801 gatgttggag agtgcatgga taatttattg ggtatgctta taacactatt ttgtatagat
10861 tctactattg atttgggtga gtattgtgat gatatactta agaggtcaac tgtattacaa
10921 tcggttactc aagagttttc gcacataccc tcgtatgctg aatatgaaag agctaagagt
10981 atttatgaaa aggttttagc cgattctaaa aatggtggtg taacacagca agagcttgct
11041 gcatatcgta atgctgccaa tattgcaaag tcagtttttg atagagactt ggctgttcaa
11101 aagaagttag atagcatggc agaacgtgct atgacaacaa tgtacaaaga ggcgcgtgta
11161 actgatagaa gagcaaaatt agtttcatca ttacatgcac tacttttttc aatgcttaag
11221 aaaatagatt ctgaaaagct taatgtttta tttgaccagg cgaatagtgg tgttgtaccc
11281 ctagcaactg ttccaattgt ttgtagtaat aagcttaccc tcgttatacc tgacccagag
11341 acgtgggtca agtgtgtgga ggttatgcat gttacatatt caacagttgt ttggaatata
11401 gactgtgtta ctgatgccga tggcacagag ttacatccca cttctacagg tagtggattg
11461 acttactgta taagtggtga taatatagca tggcctttaa aggttaactt gactaggaat
11521 gggcataata aggttgatgt tgccttgcaa aacaatgagc ttatgcctca cggtgtaaag
11581 acaaaggctt gcgtagcagg tgtagatcaa gcacattgta gcgttgagtc taaatgttat
11641 tatacaagta ttagtggcag ttcagttgta gccgctatta cttcttcaaa ttcaaatctg
11701 aaagtagcct cttttttgaa tgaggcaggt aatcagattt atgtagactt agacccacca
11761 tgtaaatttg gtatgaaagt gggtgataag gttgaagttg tttacctgta tttaataaaa
11821 aatacgaggt ctatcgtaag aggtatggta cttggtgcta tatctaatgt tgttgtgtta
11881 caatctaaag gtcatgagac agaggaagtg gatgctgtag gcattctctc actttgttct
11941 tttgcagtag atcctgcgga tacatattgt aaatatgtgg cagcaggtaa tcaaccttta
12001 ggtaactgtg ttaaaatgtt gacagtacat aatggtagtg gttttgcaat aacatcaaag
12061 ccaagtccaa ctccagatca ggattcttat ggaggagttt ctgtgtgtct ttattgtaga
12121 gcacatatag cacaccctgg cggagcagga aatttagatg cacgctgtca atttaaaggt
12181 tcttttgtgc aaatacctac tacggagaaa gatcctgtcg gattctgtct acgtaacaag
12241 gtttgcactg tttgtcagtg ttggattggt tatggatgtc agtgtgattt acttagacaa
12301 cctaaacctt ctgttcagtc agttgctgtt gcatctgatt ttgataagaa ttatttaaac
12361 agggtacggg gtggcagtgc ggctcggctg ttacccctag ctcatggatg tggcccgatg
12421 ttgtatggcg agcctttgat gtttgtaata aggaatcagc cggtatgttt caaaatttga
12481 agcgtaaatg cggaagattc caagaagtac gggatactga agatggaatt cttgagtatt
12541 gtgattctta ttttggggtt aaacaaacca ctcctagtaa ttatgaacat gaaaaggctt
12601 gttatgaaga attaaagtca gaagtaacag ctgatcatga tttttttgtg ttcaataaga
12661 acatttttaa tattagtagg cagaggctta ctaagtatac taagatggac ttttgctacg
12721 ctttgaggca ttttgaccca aaggactgcg aagttcttaa agaaatactt gtcacttatg
12781 gttgtattga agattatcac cctaagtggt ttgaagagaa taaggattgg tacgacccaa
12841 ttgaaaaccc aaaatattat gccatgttgg ctaaaatggg gcctattgta cgacgtgctt
12901 tattgaatgc tattgagttc tcaaacctca tggttgaaaa aggttatgtt ggtgttatta
12961 cacttgataa ccaagatctt aatggcaaat tttatgactt tggtgatttt cagaagacag
13021 cacctggtgc tggtgttcct gtttttgata catattattc ttacaagatg cccatcattg
13081 ccaagacgga tgcttttgca cctgagaggt attttgaata tgatgtgcat aagggttata
13141 aatcttatga tctcctcaag tatgattata ctgaggagaa acaagagttg tttcaaaagt
13201 actttaagta ctgggatcaa gagtatcacc ctaactgtcg cgactgtagt gatgacaggt
13261 gtttgataca ttgtgcatac ttcaccatct tgttttctag acttgtaccg cagacttctt
13321 tcggtaattt gtgtagaaag gtttttgttg atggtgtgcc atttattgct acatgtggct
13381 atcattctaa ggaacttggt gttattaaga atcaagataa caccatgtca ttttcaaaaa
13441 tgggtttatg tcaactcatg cagtttgttg gagatcctgc tttgtttgtg ggaacatcca
13501 ataattttgt tgatcttaga acgtcttgtt ttagtgtttg tgcgttatca tctggtatta
13561 ctcatcaaac ggtaaagcca ggtcacttta acaaggattt ctatgattct gcagagaagg
13621 ctggtatgtt taaggagggt tcgtcgctac cacttaaaca ttttttctat cctcaaactg
13681 gtaatgctgc tatatacgat tatgaatatt atcgttatat caggcctacc atgtttgaca
13741 tatgtcaaat tctattttgt tttgaagaga cttctaaata ttttgaatgt tatgaaggcg
13801 gctgtatacc agcaggccaa gtgttggtta acaactttga taagagtcca ggttatccgt
13861 tcaataagtt tggaagggcc cggctctatt atgaaaagag tcttgaggag caggaccaac
13921 tctttgagag tacaaagaag aatgtcctac ctactatatc tcaaaagaat ttaaaatatg
13981 ccatatccgc gaaaaataga gcgcgtacag tggcaggtgt gtctatcctt tctactaaga
14041 ctaataggca gtttcatcag aagattctta agtctattgt caacactaga aacgctcctg
14101 ttgttattgg aacaaccaag ttttatggcg gttgggacaa catgttgaga aaccttattc
14161 agggtgttga agacccaatt cttatgggtt gggattatcc aaagtgtgat agagcaatgc
14221 ctaatttgtt gcgtattgcg gcatcttttg tactcgctcg taaacacact atttgttgta
14281 cttggtcaga acgcgtttat tggttgtata tagaatgcgc tcaggtttta tcagaaactg
14341 tcttagctac aggtggtata tatgtgaaac ctggtggtac ttgcagtgga gatgctacta
14401 ctgcttatgc aaacagtgtt ttcaacataa tacaagccac atctgctatt gttgcgcgtc
14461 ttttgagtgt tataacgcga gatattgtat atgaagacat tatgagcttg cagtatgaat
14521 tgtaccagca ggtctattgg cgagtcaatt ttgacccagc atttgttgaa aagttttatt
14581 cttatttttg taagaatttc tcattgatga tcttgtctga cgacggtgtt gtttgttaca
14641 acaacacatt agccaaacaa ggtcttgtag cagatatttc tggttttaga gaagttctct
14701 actatcaaaa taatgttttc atggccgatt ctaagtgttg ggttgagcct gacttagaga
14761 aaggcccaca tgaattttgt tcacaacaca caatgttagt ggaggttgat ggtgagccta
14821 gatacttgcc atatccagac ccatcacgta ttttgtgtgc atgtgttttt gtaggtgatt
14881 tggataagac agaatctgtg gctgttatgg agcgttatat cgctcttgcc atagatgcgt
14941 acccactagt acatcatgaa aatgaggagt acaagaaggt attctttgtg cttctttcat
15001 acatcagaaa actctatcaa gagctttctc agaatatgct tatggactac tcttttgtaa
15061 tggatataga taagggtagt aaattttggg aacaggagtt ctatgagaat atgtatagag
15121 ctcctacgac tttacaatct tgtggcgttt gtgtagtttg taatagtcaa actatactac
15181 gctgcggtaa ttgtattcgt aaaccgtttt tgtgttgtaa gtgttgctat gaccacgtca
15241 tgcatacgga ccacaaaaat gttttatcta taaatcctta tatttgctca cagctatgtt
15301 gcggtgaagc agatgttact aaattgtatc tcggggctat gtcgtacttc tgtggtaatc
15361 ataaaccgaa attgtcaata ccgttagtat ctaatggtac tgtttttgga atttacaggg
15421 ctaattgtgc tggtagtgaa aatgttgatg attttaatca actagctact actaattggt
15481 ccattgtcca accttatatt ttagcaaatc gctgtagaga ttcattgaga cgttttgctg
15541 cagagacagt aaaagccaca gaagaattac atatgcaaca atttgcaagt gcagaagtac
15601 gagaagtatt ctcagatcga gaattgattc tatcatggga accaggaaaa accaggccgc
15661 cattgaaaag aaattatgga ttcacaggtt atcactttac aagaactagt aaggtgcagc
15721 ttggtgattt tacatttgaa aaaggtgaag gtaaggatgt tgtctattat aaagcaacgt
15781 ctactgctaa attgtctgaa ggagacattt ttgttttatc ctcacacaat gttgtttctc
15841 ttgaagcgcc aacgttgtgt ccacagcaaa ccttttcaag gtttgttatt ttaagaccta
15901 ttgtaatggt accggaatgt tttgtgaaca acattccact ctatcattta gtaggtatgc
15961 agaagcgtac tacagtacaa ggtcccccag gcagtggtat atcacatttt gctataggcc
16021 ttgcagcata cttaagtatt gctcgtgttg tatttactgc atgttcgcat gcagctgtag
16081 atgctttatg tgaaaaagct tttatgtttc ttatagtaga agattgcact cgtatagtac
16141 cccaaaggac ttctgtcgat tgcttctcaa aatttatagc tatcgacaca ggcaaaaagt
16201 acattttaag aagtattatg gccttgccgg aagtaagttg tgatatactt ttggtagacc
16261 aggtaagtat gatgaccaat tacgaaatgt cctttattat tggtatgata aattaccaat
16321 atgtagagta tgtaggtcat ccggctcaat taccggcacc ccgcacttta cttattggtt
16381 cactttctcc aaaggattat attgttgtca caaacctttt ggtttgtgtt atacccgaca
16441 ttttccttgc aaagtgttac cgttgtccca agaaaattgt agacaccgtt tctactcttg
16501 tatatgttgg aaagtttatc gcaaatatcc cggaatcacg tcagtgtttc aaggttatag
16561 ttattattgg tatttcagat gtaggacaag aaagtggttc agcctacaac acaactcaat
16621 tagaatttgt gaaagatttt gtctgtcgca atatggaatg gcgggaagca acattcattt
16681 caccttacaa tgctatgaac cagagagcct accgtatgct tggacttatt gttcagacag
16741 tagactcgtc tcaaggttca gagtatgatt atgttatctt ctgtgttact gcagattcgc
16801 agcatgcact gaatattata agattcaatg tggcgcttac aagagccaag cgtggtatac
16861 tagttgtcat gcgtcagcga gaagaattgt attctgctct tatgtttaca gagctagaaa
16921 gtgtagcaag tctgcaaggt acaggcttgt ttataatttg caacaaagaa ttaagtggtg
16981 tccatccagc ttatgcagtc acaactatgg ctcttgctgc aacttatata gttatagaag
17041 aacttgctgc acttgttatc gtggaagctg gttcagaaat aacatataaa catcttattt
17101 ctttgttagg gtttaagatg agtgttaatg ttgaaggctg ccacaacatg tttataacac
17161 gtgatgaggc tatccgcaac gtaagaggtt gggtaggttt tgatgtagaa gcaacacatg
17221 cttgcggtac taacattggt actaacctgc ctttccaagt aggtttctct actggtgcac
17281 actttgtagt cacgcctgag ggacttgtag atacttcaat aggcaataat tttgagcctg
17341 tgaattctaa agcacctcca ggtgaacaat ttaaccactt gagagcgtta ttcaaaagtg
17401 ctaaaccttg gcatgttgta aggccaagga ttgtgcaaat gttagcggat aacctgtgca
17461 acgtttcaga ttgtgtagtg ttggtcacgt ggcgtcatgg cctagaatta actactttgt
17521 gtttttttgt taaaataggc aaggaccaag tttgttcttg tggttctaga gcaacaactt
17581 ttaattctca tactcaggct tatgcttgtt ggaagcattg cttgggtttt gattttgttt
17641 ataatccact cttagtggaa attcagcagg ggggttattc tgggaaccta caatttaacc
17701 atgattttca ttgtaatgtg catggacatg cacatgtaac ttctgcggat gccattatga
17761 cccgttgtct tgcaatatta tatgcatttt gtcaaaatgt caactgggac ttaacttacc
17821 ctcattttgc aaatgaggat gaagttaatt ctagctgtag atatttacaa cgcacgtatc
17881 ttaatgcatg tgttgatgct cttaaagtta acgttgtcta tgatataggc aaccctaaag
17941 gtataaaatg tgttagacgt ggagacttaa attttagatt ctatcgatcg aatccaatag
18001 tacccaatgt caagcagttt gagtatgatt ataatcagca caaagataag tttgctgatg
18061 gtctttgtat gttttggaat tgtaatgtgg attgttatcc tcgatattcc ttggtttgca
18121 gatacgacac acgaaatttg agtgtgttta acttacctgg ttgtaatggt ggtagcttgt
18181 atgtcaacaa gcatgcattc cacacacctt actttgatcg cactagcttt cgtaatttga
18241 aagctatgcc attctttttc tatgactcat cgccttgcga gaccattcga gtggatggag
18301 ttgcgcaaga ccttgtgtca ctagctacga aagattggat cacaaagtgc aacataggcg
18361 gcgctgtttg taaaaagcac gcacaaatgt atgcagattt tgtgacttct tataatgcag
18421 ctgttactgc tggttttact ttttgggtta catcatattt taacccatat aatttgtgga
18481 aaagtttttc agctctccag tctatcgaca atattgctta taatatgtat aagcgtggtc
18541 attatgatgc tattgcagga gaaatgccca ttatcgtaac aggaaataaa gtttttgtta
18601 taggtcaagg cgtagaaaaa gcagtttttg ttaatcaaac aattctgccc acatctgtgg
18661 cgtttgagtt gtatgggaag agaaacattc gcacactgcc aaacaaccgt tttttgaaag
18721 gtttgggtgt agatgtgacc aatgggtttg taatttggga ttacactaac caaacaccac
18781 tataccgtaa tactgttaag gtatgtgcat acacagacat agagccaaat ggcctaatag
18841 ttctgtatga tgatagatat ggtgattacc agtcttttct agctgctgat aatgctgttt
18901 atatttctac acagtgttac aagcggtatt catacgtaga aataccgtca aacatgcttg
18961 ttcagaacgg tattccacta aaagatggag cgaatctgta tgtttataag cgtgttaatg
19021 gtgcgtttgt tacgctaccc aatacattaa acacacaggg ccgcagttat gagatttttg
19081 aacctcgtag tgacgttgag cgtgattttc tcgacatgtc agaggaggat tttgtagaaa
19141 agtatggtaa agacttaggt ctactacaca tactgtatgg tgaaattgac aaaccccaat
19201 taggtggttt gcatactgtt ataggtatgt acagactttt gcgtgagaat aaattaaatg
19261 caaagtctgt cactaattcg gattccgatg tcatgcaaaa ttattttgta ttggcagaca
19321 atggttccta caagcaagtt tgcactgttg tggatttgct gcttgatgat ttcttagaac
19381 ttcttaggaa catactgaat gagtatggta ctaataagtc aaaagttgta acagtgtcaa
19441 ttgattacca tagcataaat tttatgactt ggtttgaaga tggcattatt aaaacatgtt
19501 atccacagct tcaatcagca tggacgtgtg gttataatat gcctgaactt tacaaagttc
19561 agaattgtgt tatggaacct tgcaacattc ctaattatgg tgttggaata gcgttgccaa
19621 gtggtattat gatgaatgtg gcaaaatata cacaactttg tcaatacttt tcgaaaacaa
19681 caatgtgtgt accgcataat atgcgagtaa tgcattttgg agctggaggt gacaaaggaa
19741 tggatccagg taatacggtt cttaaacaat acctgccaga agggacactc cttggcgaaa
19801 atggtgatgt agaatatgtg tctgaagcac gtgtttctgg gctttcagat tgcaagaaat
19861 ataagacaga gcacaagttt gatcttgtga tatctgatat gtatacagac aatgattcaa
19921 aaagaaagca tgaaggcgtc gatgccaaca atggcaatga tgccgttttc atatatctct
19981 cgagttttct tcgtaataat ttggctctag gtggtagttt tactgtaaaa gtgacagaga
20041 caagttggca cgaagtttta tatgacattg cacaggattg tgcatggtgg acaatgtttt
20101 gtacagcagt gaatgcctct tgttcagaag aattcttggt gggtgttaat tatttgggtg
20161 caagtgaaaa ggttaaggtt agtggaaaaa cgctgcacgc aaattgtata tttaggagga
20221 cttgtaatta tttacaaacc tctgcttata gtatatttga cgtggttaag tttgatttgt
20281 gtttgaaagc aatgccagtt gttaattgga aaactgaaca aaagagagac ttagtcttta
20341 attttattaa gtgtggtaag ttactggtaa gagatgttgg taacacctct tttactagtg
20401 actcttttgt gtgtactatg tagtgctgct ttgtatgaca gtagttctta cgtgtactac
20461 taccaaagtg ccttcagacc acctaatggt tggcatttac atgggggtgc ttatgcggta
20521 gttaatattt ctagcgaatc taataatgca ggctcttcat ctgggtgtac tgttggtact
20581 attcatggtg ctcgtgttgt taatgcttct tctatagcta tgacggcacc gtcatcaggt
20641 atggcttggt ctagcagtca gttttgtact gcacactgta acttttcaga tactacagtg
20701 tttgttacac attgttataa atatgatggg tgtcctataa ctggcatgct tcaacagaat
20761 ttattacgtg tatctgctat gaaaaatggc cagcttttct ataatttaac agttagtgta
20821 gccaagtacc ctacttgtaa atcatttcag tgtgttaata attttacatc cgtatattta
20881 aatggtgatc ttgtttacac ctctaatgag accacagatg ttacatctgc aggtgtttat
20941 tttaatgctg gtggacctat aacttataaa gttatgagag aagttaaagc cctggcttat
21001 tttgttaatg gtactgcaca agacgttatt ttgtgtggtg gttcacctag aggcttgtta
21061 gcatgccagt ataataccgg caatttttca gatggctttt atccttttat taatagtagt
21121 ttagttaagc agaagtttat agtctatcgt gaaaatagtg ttaatactac ttttacgtta
21181 cactatttca gttttcataa tgagactggc gccaacccta atcctagtgg tgttcagaat
21241 attcaaattt accaaacaca aacagctcag agtggttatt ataattttaa tttttccttt
21301 ctgagtagtt ttgtttataa ggagtctaat tttatgtatg gatcttatca cccaagttgt
21361 atttttagac tagaaactat taataatggc tgggggttta attcactttc agtttcattt
21421 gcttacggtc ctcttcaagg gggttgcaag caatctgtct ttagtggtag agcaacttgt
21481 tgttatgctt attcatacgg aggtccttcg ttgtgtaagg gtgtttattt aggtgagtta
21541 aaaagtgatt tcgaatgtgg actgttagtt tatgttacta agagcgatgg ctctcgtata
21601 caaacagcca ctcaaccgcc agttataact caacacattt acaaaaatat tactttaaat
21661 acttgtgttg attataatat atatggcaga actggccaag gttttattac taatgtaacc
21721 gactcagctg ttagttataa ttatctagca gacgcaggtt tggctatttt agatacatct
21781 ggttccatag acatctttgt tgtacaaggt gaatatggtc ttacttatta taaggttaac
21841 ccttgcgaag atgtcaacca gcagtttgta gtttctggtg gtcaattagt aggtattctt
21901 acttcacgta atgagcctgg tactcagctt cttgagaacc agttttacat caaaatcact
21961 aatggaacac gtcgttttag acgttctatt actgaaaaag ttgcaaattg cccttatgtt
22021 agttatggta agttttgtat aaaacctgat ggttcaattg ccacaatagt accaaaacaa
22081 ttggaacagt ttgtggcacc tttacttaat gttactgaaa atgtgctcat acctaacagt
22141 tttaatttaa ctgttacaga tgagtacata caaacgcgta tggataaggt ccaaattaat
22201 tgtctgcagt atgtttgtgg caattctctg gattgtagag agttgtttca acaatatggg
22261 cctgtttgcg acaacatatt gtctgtagta aatagtgttg gtaaaaaaga agatatggaa
22321 cttttgaatt tctattcttc tactaaaccg gctggtttta atacaccagt tcttagtaat
22381 gttagcactg gtgagtttaa tatttctctt ctgttaacaa ctcctagtag tcccagaagg
22441 cgttctttta ttgaagatct tctatttaca agcgttgaat ctgttggatt accaacagat
22501 gacgcataca aaaattgcac tgcaggacct ttaggctttc ttaaggacct tgcatgtgct
22561 cgtgaatata atggtttgct tgtgttgcct cccattataa cagcagaaat gcaaactttg
22621 tatactagtt ctctagtagc ttctatggct tttggtggta ttactgcagc tggtgctata
22681 ccttttgcca cacaactgca ggctagaatt aatcacttgg gtattaccca gtcacttttg
22741 ttgaagaatc aagaaaaaat tgctgcttcc tttaataagg ccatcggtcg tatgcaggaa
22801 ggttttagaa gtacatctct agcattacaa caaattcaag atgttgttaa taagcagagt
22861 gctattctta ctgagactat ggcatcactt attaaaaatt ttggtgctat ttctactatg
22921 attcaagaaa tataccagca atttgacgcc atacaagcaa atgctcaagt ggatcgtctt
22981 ataactggta gattgtcatc actttctgtt ttagcatctg ctaagcaggc ggagcatatt
23041 agagtgtcac aacagcgtga gttagctact cagaagatta atgagtgtgt taagtcacag
23101 tctaataggt actccttttg tggtaatgga cgacatgttc taaccatacc gcaaaatgca
23161 cctaatggta tagtgtttat acacttttct tatactccag atagttttgt taatgttact
23221 gcaatagtgg gtttttgtgt aaagccagct aatgctagtc agtatgcaat agtaccagtt
23281 aatggtaggg gtatttttat acaagttaat ggtagttact acatcactgc acgagatatg
23341 tatatgccaa gagctattac tgcaggagat atagttactc ttacttcttg tcaagcaaat
23401 tatgtaagtg taaataagac cgtcattact acattcgtag acaatgatga ttttgatttt
23461 aatgacgaat tgtcaaaatg gtggaatgct actaagcatg agctaccaga ctttgacaaa
23521 ttcaattaca cagtacctat acttgatatt gatagtgaaa ttgatcgtat tcaaggcgtt
23581 atacagggtc ttaatgactc ttcaatagac cttgaaaaac tttcaatact caaaacttat
23641 attaagtggc cttggtatgt gtggttagcc atagcttttg ccactattat cttcatctta
23701 atactaggat gggttttctt catgactgga tgttgtggtt gttgttgtgg atgccttggc
23761 attatgcctc taatgagaaa gtgtggtaaa aaatcctctt attacacgac ttttgataac
23821 gatgtggtaa cttaacaata cagacctaaa aagtctgttt aatgattcaa agtcccacgt
23881 ccttcctaat agtattaatt tttctttggt gtaaacttgt actaagttgt tttagagagt
23941 ttattatagc gctccaacaa ctaatacaag ttttactcca aattatcaat agtaacttac
24001 agcctagcct gaccctttgt cacagtctag actaatgtta aacttagaag caatttttga
24061 aactggtgag caagagattc aaaaaatcag ttttaattta cagcatattt caagagtatt
24121 aaccacagaa gtatttgacc cctttgacta ttgttattac agaggaggta atttttggga
24181 aatagagtca gctgaagatt gttcaggtga tgatgaattt attgaataag tcgctagagg
24241 agaatggaag ttttctaaca gcgctttaca taattgtagg atttttagca ctttatcttc
24301 taggtagagc acttcaagca tttgtacagg ctgctgatgc ttgttgttta ttttggtata
24361 catgggtagt aattccagga gctaagggta cagcctttgt atacaagtat acatatggta
24421 gaaaacttaa caatccggaa ttagaagcag ttattgttaa cgagtttcct aagaacggtt
24481 ggaataataa aaatccagca aattttcaag atgtccaacg agacaaattg cactcttgac
24541 tttgaacagt cagttgagct ttttaaagag tataatttat ttataactgc attcttgttg
24601 ttcttaacca taatacttca gtatggctat gcaacaagaa gtaagtttat ttatatactg
24661 aaaatggtag tgttatggtg tttttggccc cttaacattg cagtaggtgt aatttcatgt
24721 atatacccac caaacacagg aggtcttgtc gcagcgataa tacttacagt gtttgcgtgt
24781 ctgtcttttg taggttattg gatccagagt atcagactct ttaagcggtg taggtcatgg
24841 tggtcattta accccgaatc taatgccgta ggttcaatac tcctaactaa tggtcaacaa
24901 tgtaattttg ctatagagag tgtgccaatg gtgctttctc caattataaa gaatggtgtt
24961 ctttattgtg agggtcagtg gcttgctaag tgtgaaccag accacttgcc taaagatata
25021 tttgtttgta caccggatag acgtaatatc taccgtatgg tgcagaaata tactggtgac
25081 caaagcggaa ataagaaacg gtttgctacg tttgtctatg caaagcagtc agtagatact
25141 ggcgagctag aaagtgtagc agcaggagga ggtagtcttt acacataaat gtgtgtgtgt
25201 agagagtatt taaaattatt ctttaatagt gcctctattt taagagcgca taatagtatt
25261 atttttgagg atattaatat aaatcctctc tgttttatac tctcttttca agagctatta
25321 tttaaaaaac agtttttcca ctcttttgtg ccaaaaacta ttgttgttaa tggtgtaacc
25381 tttcaagtag ataatggaaa agtctactac gaaggaaaac caatttttca gaaaggttgt
25441 tgtaggttgt ggttgagtta taaaaaagat taaactacct actacactta tttttataag
25501 aggcgtttta tcttacaagc gcttaataaa tacggacgat gaaatggctg actagttttg
25561 taagggcagt tatttcgtgt tacaaacccc tattattaac tcaattaaga gtattagaaa
25621 agttaatttt agaccatgga acaaaccaca tcttaacgtg tattaggcgc gtgattttgt
25681 ttcaattaga tttagtttat aggttggcgt atacgcccac ccaatcgctg gtatgaataa
25741 tagtaaagat aatccttttc gcggagcaat agcaagaaaa gcgcgaattt atctgagaga
25801 aggattagat tgtgtttact ttcttaacaa agcaggacaa gcagagtctt gtcccgcgtg
25861 tacctctcta gtattccaag ggaaaacttg tgaggaacac aaatataata ataatctttt
25921 gtcatggcaa gcggtaaggc aactggaaag acagacgccc cagcgccagt catcaaacta
25981 ggaggaccaa agccacctaa agttggttct tctggaaatg tatcttggtt tcaagcaata
26041 aaagccaaga agttaaatac acctccgccc aagtttgaag gtagcggtgt tcctgataat
26101 gaaaacataa aaccaagcca gcagcatgga tactggaaac gccaagccag gtttaagcca
26161 ggtaaaggtg gaagaaaacc agtcccagat gcttggtact tttactatac tggaacagga
26221 ccagccgctg acctgaactg gggtgatacc caagatggta tagtgtgggt tgctgctaag
26281 ggtgctgata ctaaatttag atctaatcag ggtacaagtg attctgacaa gtttgaccaa
26341 tatccactac gattctcgga cggaggacct gatggtaatt tccgttggga cttctttcct
26401 ctgaatcgtg gcaggagtgg gagatcaaca gcagcttcat cagcagcatc tagtagagca
26461 ccatcacgtg aagtttcgcg tggtcgcagg agtggttctg aagatgatct tattgctcgt
26521 gcagcaagga taattcagga tcagcagaag aagggttctc gcattacaaa ggctaaggct
26581 gatgaaatgg ctcaccgccg gtattgcaag cgcactattc cacctaatta taaggttgat
26641 caagtgtttg gtccccgtac taaaggtaag gagggaaatt ttggtgatga caagatgaat
26701 gaggaaggta ttaaggatgg gcgcgttaca gcaatgctca acctagtccc tagcagccat
26761 gcttgtcttt tcggaagtag agtgacgccc agacttcaac cagatgggct gcacttcaaa
26821 tttgaattta ctactgtggt cccacgtgat gatccgcagt ttgataatta tgtaaaaatt
26881 tgtgatcagt gtgttgatgg tgtaggaaca cgtccaaaag atgatgaacc aagaccaaag
26941 tcacgctcaa gttcaagacc tgcaacaaga ggaaattctc cagcgccaag acagcagcgc
27001 cctaagaagg agaaaaagcc aaagaagcag gatgatgaag tggataaagc attgacctca
27061 gatgaggaga ggaacaatgc acagctggaa tttgatgatg aacccaaggt aattaactgg
27121 ggggattcag ccctaggaga gaatgaactt tgagtaaaat tcaatagtaa gagttaagga
27181 agataggcat gtagcttgat tacctacatg tctatcgcca gggaaatgtc taatctgtct
27241 acttagtagc ctggaaacga acggtagacc cttagatttt aatttagttt attttttagt
27301 ttagttaagt tagttagagt agtataaaga tgccagtgcc ggggccacgc ggagtacgac
27361 cgagggtaca gcactaggac gcccattagg ggaagagcta aattttttag tttttaagtt
27421 aaaggtttta aatttggact atacgttata ggttaaaaaa aaaa
//
