LOCUS NC_074955 7207 bp ss-RNA linear VRL 05-MAY-2023
DEFINITION Paslahepevirus balayani nonstructural protein and structural viral
protein genes, complete cds.
ACCESSION NC_074955
VERSION NC_074955.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Paslahepevirus balayani
ORGANISM Paslahepevirus balayani
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
Hepelivirales; Hepeviridae; Orthohepevirinae; Paslahepevirus.
REFERENCE 1 (bases 1 to 7207)
AUTHORS Tam,A.W., Smith,M.M., Guerra,M.E., Huang,C.C., Bradley,D.W.,
Fry,K.E. and Reyes,G.R.
TITLE Hepatitis E virus (HEV): molecular cloning and sequencing of the
full-length viral genome
JOURNAL Virology 185 (1), 120-131 (1991)
PUBMED 1926770
REFERENCE 2 (bases 1 to 7207)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (03-MAY-2023) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to M73218.
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..7207
/organism="Paslahepevirus balayani"
/mol_type="genomic RNA"
/db_xref="taxon:1678143"
gene 28..5109
/locus_tag="QJ743_gp1"
/db_xref="GeneID:80512052"
CDS 28..5109
/locus_tag="QJ743_gp1"
/note="putative"
/codon_start=1
/product="nonstructural protein"
/protein_id="YP_010775524.1"
/db_xref="GeneID:80512052"
/translation="MEAHQFIKAPGITTAIEQAALAAANSALANAVVVRPFLSHQQIE
ILINLMQPRQLVFRPEVFWNHPIQRVIHNELELYCRARSGRCLEIGAHPRSINDNPNV
VHRCFLRPVGRDVQRWYTAPTRGPAANCRRSALRGLPAADRTYCLDGFSGCNFPAETG
IALYSLHDMSPSDVAEAMFRHGMTRLYAALHLPPEVLLPPGTYRTASYLLIHDGRRVV
VTYEGDTSAGYNHDVSNLRSWIRTTKVTGDHPLVIERVRAIGCHFVLLLTAAPEPSPM
PYVPYPRSTEVYVRSIFGPGGTPSLFPTSCSTKSTFHAVPAHIWDRLMLFGATLDDQA
FCCSRLMTYLRGISYKVTVGTLVANEGWNASEDALTAVITAAYLTICHQRYLRTQAIS
KGMRRLEREHAQKFITRLYSWLFEKSGRDYIPGRQLEFYAQCRRWLSAGFHLDPRVLV
FDESAPCHCRTAIRKALSKFCCFMKWLGQECTCFLQPAEGAVGDQGHDNEAYEGSDVD
PAESAISDISGSYVVPGTALQPLYQALDLPAEIVARAGRLTATVKVSQVDGRIDCETL
LGNKTFRTSFVDGAVLETNGPERHNLSFDASQSTMAAGPFSLTYAASAAGLEVRYVAA
GLDHRAVFAPGVSPRSAPGEVTAFCSALYRFNREAQRHSLIGNLWFHPEGLIGLFAPF
SPGHVWESANPFCGESTLYTRTWSEVDAVSSPARPDLGFMSEPSIPSRAATPTLAAPL
PPPAPDPSPPPSAPALAEPASGATAGAPAITHQTARHRRLLFTYPDGSKVFAGSLFES
TCTWLVNASNVDHRPGGGLCHAFYQRYPASFDAASFVMRDGAAAYTLTPRPIIHAVAP
DYRLEHNPKRLEAAYRETCSRLGTAAYPLLGTGIYQVPIGPSFDAWERNHRPGDELYL
PELAARWFEANRPTRPTLTITEDVARTANLAIELDSATDVGRACAGCRVTPGVVQYQF
TAGVPGSGKSRSITQADVDVVVVPTRELRNAWRRRGFAAFTPHTAARVTQGRRVVIDE
APSLPPHLLLLHMQRAATVHLLGDPNQIPAIDFEHAGLVPAIRPDLGPTSWWHVTHRW
PADVCELIRGAYPMIQTTSRVLRSLFWGEPAVGQKLVFTQAAKPANPGSVTVHEAQGA
TYTETTIIATADARGLIQSSRAHAIVALTRHTEKCVIIDAPGLLREVGISDAIVNNFF
LAGGEIGHQRPSVIPRGNPDANVDTLAAFPPSCQISAFHQLAEELGHRPVPVAAVLPP
CPELEQGLLYLPQELTTCDSVVTFELTDIVHCRMAAPSQRKAVLSTLVGRYGGRTKLY
NASHSDVRDSLARFIPAIGPVQVTTCELYELVEAMVEKGQDGSAVLELDLCNRDVSRI
TFFQKDCNKFTTGETIAHGKVGQGISAWSKTFCALFGPWFRAIEKAILALLPQGVFYG
DAFDDTVFSAAVAAAKASMVFENDFSEFDSTQNNFSLGLECAIMEECGMPQWLIRLYH
LIRSAWILQAPKESLRGFWKKHSGEPGTLLWNTVWNMAVITHCYDFRDFQVAAFKGDD
SIVLCSEYRQSPGAAVLIAGCGLKLKVDFRPIGLYAGVVVAPGLGALPDVVRFAGRLT
EKNWGPGPERAEQLRLAVSDFLRKLTNVAQMCVDVVSRVYGVSPGLVHNLIGMLQAVA
DGKAHFTESVKPVLDLTNSILCRVE"
misc_feature 127..1086
/locus_tag="QJ743_gp1"
/note="Viral methyltransferase; Region: Vmethyltransf;
pfam01660"
/db_xref="CDD:396298"
misc_feature 1321..1803
/locus_tag="QJ743_gp1"
/note="Hepatitis E cysteine protease; Region:
Peptidase_C41; pfam05417"
/db_xref="CDD:283151"
misc_feature 2083..2382
/locus_tag="QJ743_gp1"
/note="Protein of unknown function (DUF3729); Region:
DUF3729; pfam12526"
/db_xref="CDD:372164"
misc_feature 2425..2757
/locus_tag="QJ743_gp1"
/note="X-domain (or Mac1 domain) of viral non-structural
protein 3 and related macrodomains; Region:
Macro_X_Nsp3-like; cd21557"
/db_xref="CDD:438957"
misc_feature order(2443..2451,2461..2481,2677..2682,2686..2700)
/locus_tag="QJ743_gp1"
/note="ADP-ribose binding site [chemical binding]; other
site"
/db_xref="CDD:438957"
misc_feature 2947..3582
/locus_tag="QJ743_gp1"
/note="Viral (Superfamily 1) RNA helicase; Region:
Viral_helicase1; pfam01443"
/db_xref="CDD:366646"
misc_feature 3961..4782
/locus_tag="QJ743_gp1"
/note="catalytic core domain of RNA-dependent RNA
polymerase (RdRp) in the family Hepeviridae of
positive-sense single-stranded RNA [(+)ssRNA] viruses;
Region: Hepeviridae_RdRp; cd23259"
/db_xref="CDD:438109"
misc_feature 4390..4434
/locus_tag="QJ743_gp1"
/note="conserved polymerase motif A; other site"
/db_xref="CDD:438109"
misc_feature 4570..4641
/locus_tag="QJ743_gp1"
/note="conserved polymerase motif B; other site"
/db_xref="CDD:438109"
misc_feature 4657..4701
/locus_tag="QJ743_gp1"
/note="conserved polymerase motif C; other site"
/db_xref="CDD:438109"
gene 5106..5477
/locus_tag="QJ743_gp2"
/db_xref="GeneID:80512050"
CDS 5106..5477
/locus_tag="QJ743_gp2"
/codon_start=1
/product="structural viral protein"
/protein_id="YP_010775525.1"
/db_xref="GeneID:80512050"
/translation="MNNMSFAAPMGSRPCALGLFCCCSSCFCLCCPRHRPVSRLAAVV
GGAAAVPAVVSGVTGLILSPSQSPIFIQPTPSPPMSPLRPGLDLVFANPPDHSAPLGV
TRPSAPPLPHVVDLPQLGPRR"
misc_feature 5133..5474
/locus_tag="QJ743_gp2"
/note="Hepatitis E virus ORF-2 (Putative capsid protein);
Region: HEV_ORF1; pfam02444"
/db_xref="CDD:280583"
gene 5147..7129
/locus_tag="QJ743_gp3"
/db_xref="GeneID:80512051"
CDS 5147..7129
/locus_tag="QJ743_gp3"
/codon_start=1
/product="structural viral protein"
/protein_id="YP_010775526.1"
/db_xref="GeneID:80512051"
/translation="MRPRPILLLLLMFLPMLPAPPPGQPSGRRRGRRSGGSGGGFWGD
RVDSQPFAIPYIHPTNPFAPDVTAAAGAGPRVRQPARPLGSAWRDQAQRPAVASRRRP
TTAGAAPLTAVAPAHDTPPVPDVDSRGAILRRQYNLSTSPLTSSVATGTNLVLYAAPL
SPLLPLQDGTNTHIMATEASNYAQYRVARATIRYRPLVPNAVGGYAISISFWPQTTTT
PTSVDMNSITSTDVRILVQPGIASELVIPSERLHYRNQGWRSVETSGVAEEEATSGLV
MLCIHGSLVNSYTNTPYTGALGLLDFALELEFRNLTPGNTNTRVSRYSSTARHRLRRG
ADGTAELTTTAATRFMKDLYFTSTNGVGEIGRGIALTLFNLADTLLGGLPTELISSAG
GQLFYSRPVVSANGEPTVKLYTSVENAQQDKGIAIPHDIDLGESRVVIQDYDNQHEQD
RPTPSPAPSRPFSVLRANDVLWLSLTAAEYDQSTYGSSTGPVYVSDSVTLVNVATGAQ
AVARSLDWTKVTLDGRPLSTIQQYSKTFFVLPLRGKLSFWEAGTTKAGYPYNYNTTAS
DQLLVENAAGHRVAISTYTTSLGAGPVSISAVAVLAPHSALALLEDTLDYPARAHTFD
DFCPECRPLGLQGCAFQSTVAELQRLKMKVGKTREL"
misc_feature 5342..7120
/locus_tag="QJ743_gp3"
/note="Structural protein 2; Region: SP2; pfam03014"
/db_xref="CDD:367296"
ORIGIN
1 aggcagacca catatgtggt cgatgccatg gaggcccatc agtttattaa ggctcctggc
61 atcactactg ctattgagca ggctgctcta gcagcggcca actctgccct ggcgaatgct
121 gtggtagtta ggccttttct ctctcaccag cagattgaga tcctcattaa cctaatgcaa
181 cctcgccagc ttgttttccg ccccgaggtt ttctggaatc atcccatcca gcgtgtcatc
241 cataacgagc tggagcttta ctgccgcgcc cgctccggcc gctgtcttga aattggcgcc
301 catccccgct caataaatga taatcctaat gtggtccacc gctgcttcct ccgccctgtt
361 gggcgtgatg ttcagcgctg gtatactgct cccactcgcg ggccggctgc taattgccgg
421 cgttccgcgc tgcgcgggct tcccgctgct gaccgcactt actgcctcga cgggttttct
481 ggctgtaact ttcccgccga gactggcatc gccctctact cccttcatga tatgtcacca
541 tctgatgtcg ccgaggccat gttccgccat ggtatgacgc ggctctatgc cgccctccat
601 cttccgcctg aggtcctgct gccccctggc acatatcgca ccgcatcgta tttgctaatt
661 catgacggta ggcgcgttgt ggtgacgtat gagggtgata ctagtgctgg ttacaaccac
721 gatgtctcca acttgcgctc ctggattaga accaccaagg ttaccggaga ccatcccctc
781 gttatcgagc gggttagggc cattggctgc cactttgttc tcttgctcac ggcagccccg
841 gagccatcac ctatgcctta tgttccttac ccccggtcta ccgaggtcta tgtccgatcg
901 atcttcggcc cgggtggcac cccttcctta ttcccaacct catgctccac taagtcgacc
961 ttccatgctg tccctgccca tatttgggac cgtcttatgc tgttcggggc caccttggat
1021 gaccaagcct tttgctgctc ccgtttaatg acctaccttc gcggcattag ctacaaggtc
1081 actgttggta cccttgtggc taatgaaggc tggaatgcct ctgaggacgc cctcacagct
1141 gttatcactg ccgcctacct taccatttgc caccagcggt atctccgcac ccaggctata
1201 tccaagggga tgcgtcgtct ggaacgggag catgcccaga agtttataac acgcctctac
1261 agctggctct tcgagaagtc cggccgtgat tacatccctg gccgtcagtt ggagttctac
1321 gcccagtgca ggcgctggct ctccgccggc tttcatcttg atccacgggt gttggttttt
1381 gacgagtcgg ccccctgcca ttgtaggacc gcgatccgta aggcgctctc aaagttttgc
1441 tgcttcatga agtggcttgg tcaggagtgc acctgcttcc ttcagcctgc agaaggcgcc
1501 gtcggcgacc agggtcatga taatgaagcc tatgaggggt ccgatgttga ccctgctgag
1561 tccgccatta gtgacatatc tgggtcctat gtcgtccctg gcactgccct ccaaccgctc
1621 taccaggccc tcgatctccc cgctgagatt gtggctcgcg cgggccggct gaccgccaca
1681 gtaaaggtct cccaggtcga tgggcggatc gattgcgaga cccttcttgg taacaaaacc
1741 tttcgcacgt cgttcgttga cggggcggtc ttagagacca atggcccaga gcgccacaat
1801 ctctccttcg atgccagtca gagcactatg gccgctggcc ctttcagtct cacctatgcc
1861 gcctctgcag ctgggctgga ggtgcgctat gttgctgccg ggcttgacca tcgggcggtt
1921 tttgcccccg gtgtttcacc ccggtcagcc cccggcgagg ttaccgcctt ctgctctgcc
1981 ctatacaggt ttaaccgtga ggcccagcgc cattcgctga tcggtaactt atggttccat
2041 cctgagggac tcattggcct cttcgccccg ttttcgcccg ggcatgtttg ggagtcggct
2101 aatccattct gtggcgagag cacactttac acccgtactt ggtcggaggt tgatgccgtc
2161 tctagtccag cccggcctga cttaggtttt atgtctgagc cttctatacc tagtagggcc
2221 gccacgccta ccctggcggc ccctctaccc ccccctgcac cggacccttc cccccctccc
2281 tctgccccgg cgcttgctga gccggcttct ggcgctaccg ccggggcccc ggccataact
2341 caccagacgg cccggcaccg ccgcctgctc ttcacctacc cggatggctc taaggtattc
2401 gccggctcgc tgttcgagtc gacatgcacg tggctcgtta acgcgtctaa tgttgaccac
2461 cgccctggcg gcgggctttg ccatgcattt taccaaaggt accccgcctc ctttgatgct
2521 gcctcttttg tgatgcgcga cggcgcggcc gcgtacacac taaccccccg gccaataatt
2581 cacgctgtcg cccctgatta taggttggaa cataacccaa agaggcttga ggctgcttat
2641 cgggaaactt gctcccgcct cggcaccgct gcatacccgc tcctcgggac cggcatatac
2701 caggtgccga tcggccccag ttttgacgcc tgggagcgga accaccgccc cggggatgag
2761 ttgtaccttc ctgagcttgc tgccagatgg tttgaggcca ataggccgac ccgcccgact
2821 ctcactataa ctgaggatgt tgcacggaca gcgaatctgg ccatcgagct tgactcagcc
2881 acagatgtcg gccgggcctg tgccggctgt cgggtcaccc ccggcgttgt tcagtaccag
2941 tttactgcag gtgtgcctgg atccggcaag tcccgctcta tcacccaagc cgatgtggac
3001 gttgtcgtgg tcccgacgcg tgagttgcgt aatgcctggc gccgtcgcgg ctttgctgct
3061 tttaccccgc atactgccgc cagagtcacc caggggcgcc gggttgtcat tgatgaggct
3121 ccatccctcc cccctcacct gctgctgctc cacatgcagc gggccgccac cgtccacctt
3181 cttggcgacc cgaaccagat cccagccatc gactttgagc acgctgggct cgtccccgcc
3241 atcaggcccg acttaggccc cacctcctgg tggcatgtta cccatcgctg gcctgcggat
3301 gtatgcgagc tcatccgtgg tgcatacccc atgatccaga ccactagccg ggttctccgt
3361 tcgttgttct ggggtgagcc tgccgtcggg cagaaactag tgttcaccca ggcggccaag
3421 cccgccaacc ccggctcagt gacggtccac gaggcgcagg gcgctaccta cacggagacc
3481 actattattg ccacagcaga tgcccggggc cttattcagt cgtctcgggc tcatgccatt
3541 gttgctctga cgcgccacac tgagaagtgc gtcatcattg acgcaccagg cctgcttcgc
3601 gaggtgggca tctccgatgc aatcgttaat aactttttcc tcgctggtgg cgaaattggt
3661 caccagcgcc catcagttat tccccgtggc aaccctgacg ccaatgttga caccctggct
3721 gccttcccgc cgtcttgcca gattagtgcc ttccatcagt tggctgagga gcttggccac
3781 agacctgtcc ctgttgcagc tgttctacca ccctgccccg agctcgaaca gggccttctc
3841 tacctgcccc aggagctcac cacctgtgat agtgtcgtaa catttgaatt aacagacatt
3901 gtgcactgcc gcatggccgc cccgagccag cgcaaggccg tgctgtccac actcgtgggc
3961 cgctacggcg gtcgcacaaa gctctacaat gcttcccact ctgatgttcg cgactctctc
4021 gcccgtttta tcccggccat tggccccgta caggttacaa cttgtgaatt gtacgagcta
4081 gtggaggcca tggtcgagaa gggccaggat ggctccgccg tccttgagct tgatctttgc
4141 aaccgtgacg tgtccaggat caccttcttc cagaaagatt gtaacaagtt caccacaggt
4201 gagaccattg cccatggtaa agtgggccag ggcatctcgg cctggagcaa gaccttctgc
4261 gccctctttg gcccttggtt ccgcgctatt gagaaggcta ttctggccct gctccctcag
4321 ggtgtgtttt acggtgatgc ctttgatgac accgtcttct cggcggctgt ggccgcagca
4381 aaggcatcca tggtgtttga gaatgacttt tctgagtttg actccaccca gaataacttt
4441 tctctgggtc tagagtgtgc tattatggag gagtgtggga tgccgcagtg gctcatccgc
4501 ctgtatcacc ttataaggtc tgcgtggatc ttgcaggccc cgaaggagtc tctgcgaggg
4561 ttttggaaga aacactccgg tgagcccggc actcttctat ggaatactgt ctggaatatg
4621 gccgttatta cccactgtta tgacttccgc gattttcagg tggctgcctt taaaggtgat
4681 gattcgatag tgctttgcag tgagtatcgt cagagtccag gagctgctgt cctgatcgcc
4741 ggctgtggct tgaagttgaa ggtagatttc cgcccgatcg gtttgtatgc aggtgttgtg
4801 gtggcccccg gccttggcgc gctccctgat gttgtgcgct tcgccggccg gcttaccgag
4861 aagaattggg gccctggccc tgagcgggcg gagcagctcc gcctcgctgt tagtgatttc
4921 ctccgcaagc tcacgaatgt agctcagatg tgtgtggatg ttgtttcccg tgtttatggg
4981 gtttcccctg gactcgttca taacctgatt ggcatgctac aggctgttgc tgatggcaag
5041 gcacatttca ctgagtcagt aaaaccagtg ctcgacttga caaattcaat cttgtgtcgg
5101 gtggaatgaa taacatgtct tttgctgcgc ccatgggttc gcgaccatgc gccctcggcc
5161 tattttgttg ctgctcctca tgtttttgcc tatgctgccc gcgccaccgc ccggtcagcc
5221 gtctggccgc cgtcgtgggc ggcgcagcgg cggttccggc ggtggtttct ggggtgaccg
5281 ggttgattct cagcccttcg caatccccta tattcatcca accaacccct tcgcccccga
5341 tgtcaccgct gcggccgggg ctggacctcg tgttcgccaa cccgcccgac cactcggctc
5401 cgcttggcgt gaccaggccc agcgccccgc cgttgcctca cgtcgtagac ctaccacagc
5461 tggggccgcg ccgctaaccg cggtcgctcc ggcccatgac accccgccag tgcctgatgt
5521 cgactcccgc ggcgccatct tgcgccggca gtataaccta tcaacatctc cccttacctc
5581 ttccgtggcc accggcacta acctggttct ttatgccgcc cctcttagtc cgcttttacc
5641 ccttcaggac ggcaccaata cccatataat ggccacggaa gcttctaatt atgcccagta
5701 ccgggttgcc cgtgccacaa tccgttaccg cccgctggtc cccaatgctg tcggcggtta
5761 cgccatctcc atctcattct ggccacagac caccaccacc ccgacgtccg ttgatatgaa
5821 ttcaataacc tcgacggatg ttcgtatttt agtccagccc ggcatagcct ctgagcttgt
5881 gatcccaagt gagcgcctac actatcgtaa ccaaggctgg cgctccgtcg agacctctgg
5941 ggtggctgag gaggaggcta cctctggtct tgttatgctt tgcatacatg gctcactcgt
6001 aaattcctat actaatacac cctataccgg tgccctcggg ctgttggact ttgcccttga
6061 gcttgagttt cgcaacctta cccccggtaa caccaatacg cgggtctccc gttattccag
6121 cactgctcgc caccgccttc gtcgcggtgc ggacgggact gccgagctca ccaccacggc
6181 tgctacccgc tttatgaagg acctctattt tactagtact aatggtgtcg gtgagatcgg
6241 ccgcgggata gccctcaccc tgttcaacct tgctgacact ctgcttggcg gcctgccgac
6301 agaattgatt tcgtcggctg gtggccagct gttctactcc cgtcccgttg tctcagccaa
6361 tggcgagccg actgttaagt tgtatacatc tgtagagaat gctcagcagg ataagggtat
6421 tgcaatcccg catgacattg acctcggaga atctcgtgtg gttattcagg attatgataa
6481 ccaacatgaa caagatcggc cgacgccttc tccagcccca tcgcgccctt tctctgtcct
6541 tcgagctaat gatgtgcttt ggctctctct caccgctgcc gagtatgacc agtccactta
6601 tggctcttcg actggcccag tttatgtttc tgactctgtg accttggtta atgttgcgac
6661 cggcgcgcag gccgttgccc ggtcgctcga ttggaccaag gtcacacttg acggtcgccc
6721 cctctccacc atccagcagt actcgaagac cttctttgtc ctgccgctcc gcggtaagct
6781 ctctttctgg gaggcaggca caactaaagc cgggtaccct tataattata acaccactgc
6841 tagcgaccaa ctgcttgtcg agaatgccgc cgggcaccgg gtcgctattt ccacttacac
6901 cactagcctg ggtgctggtc ccgtctccat ttctgcggtt gccgttttag ccccccactc
6961 tgcgctagca ttgcttgagg ataccttgga ctaccctgcc cgcgcccata cttttgatga
7021 tttctgccca gagtgccgcc cccttggcct tcagggctgc gctttccagt ctactgtcgc
7081 tgagcttcag cgccttaaga tgaaggtggg taaaactcgg gagttgtagt ttatttgctt
7141 gtgcccccct tctttctgtt gcttatttct catttctgcg ttccgcgctc cctgaaaaaa
7201 aaaaaaa
//
