GenomeNet

Database: RefSeq
Entry: NP_000780
LinkDB: NP_000780
Original site: NP_000780 
LOCUS       NP_000780               1306 aa            linear   PRI 29-DEC-2018
DEFINITION  angiotensin-converting enzyme isoform 1 precursor [Homo sapiens].
ACCESSION   NP_000780
VERSION     NP_000780.1
DBSOURCE    REFSEQ: accession NM_000789.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1306)
  AUTHORS   Lopez-Sublet M, Caratti di Lanzacco L, Danser AHJ, Lambert M,
            Elourimi G and Persu A.
  TITLE     Focus on increased serum angiotensin-converting enzyme level: From
            granulomatous diseases to genetic mutations
  JOURNAL   Clin. Biochem. 59, 1-8 (2018)
   PUBMED   29928904
  REMARK    GeneRIF: summary of current knowledge about circulating ACE
            elevation in patients with granulomatous and non-granulomatous
            diseases.
            Review article
REFERENCE   2  (residues 1 to 1306)
  AUTHORS   Wang ZY, Li HY, Jiang ZP and Zhou TB.
  TITLE     Relationship between angiotensin-converting enzyme
            insertion/deletion gene polymorphism and prostate cancer
            susceptibility
  JOURNAL   J Cancer Res Ther 14 (Supplement), S375-S380 (2018)
   PUBMED   29970692
  REMARK    GeneRIF: Angiotensin-converting enzyme insertion/deletion gene
            polymorphism is associated with prostate cancer susceptibility.
REFERENCE   3  (residues 1 to 1306)
  AUTHORS   Silva RFD, Lacchini R, Pinheiro LC, Dionisio TJ, Jacomini A,
            Tanus-Santos JE, Amaral SL, Santos CF and Zago AS.
  TITLE     Preliminary study about the relationship between estimated training
            status and RAS polymorphisms on blood pressure and ACE activity in
            the elderly
  JOURNAL   J Renin Angiotensin Aldosterone Syst 19 (2), 1470320318782622
            (2018)
   PUBMED   29923443
  REMARK    GeneRIF: This study aimed to investigate the relationship between
            estimated training status (TS), blood pressure and
            angiotensin-converting enzyme (ACE) activity in elderly people
            classified as low or high risk to develop hypertension according to
            genetic profile.
REFERENCE   4  (residues 1 to 1306)
  AUTHORS   Pan Y and Lu H.
  TITLE     Angiotensin-converting enzyme insertion/deletion polymorphism and
            susceptibility to Kawasaki disease: a meta-analysis
  JOURNAL   Afr Health Sci 17 (4), 991-999 (2017)
   PUBMED   29937869
  REMARK    GeneRIF: study found a significant association between the ACE
            insertion/deletion polymorphism and Kawasaki disease risk -
            meta-analysis
REFERENCE   5  (residues 1 to 1306)
  AUTHORS   Pavlyushchik,O.O., Afonin,V.Y., Sarokina,V.N., Chak,T.A.,
            Khapaliuk,A.V. and Anisovich,M.V.
  TITLE     Association of the ace I/D gene polymorphism with DNA damage in
            hypertensive men
  JOURNAL   Tsitol. Genet. 50 (5), 48-58 (2016)
   PUBMED   30480916
  REMARK    GeneRIF: The study suggests that the ACE I/D polymorphism may
            contribute to mechanisms and intensity of DNA damage in
            hypertensive and normotensive individuals.
REFERENCE   6  (residues 1 to 1306)
  AUTHORS   Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, Luc
            G, Bard JM, Bara L, Ricard S et al.
  TITLE     Deletion polymorphism in the gene for angiotensin-converting enzyme
            is a potent risk factor for myocardial infarction
  JOURNAL   Nature 359 (6396), 641-644 (1992)
   PUBMED   1328889
REFERENCE   7  (residues 1 to 1306)
  AUTHORS   Wei L, Clauser E, Alhenc-Gelas F and Corvol P.
  TITLE     The two homologous domains of human angiotensin I-converting enzyme
            interact differently with competitive inhibitors
  JOURNAL   J. Biol. Chem. 267 (19), 13398-13405 (1992)
   PUBMED   1320019
REFERENCE   8  (residues 1 to 1306)
  AUTHORS   Jeunemaitre X, Lifton RP, Hunt SC, Williams RR and Lalouel JM.
  TITLE     Absence of linkage between the angiotensin converting enzyme locus
            and human essential hypertension
  JOURNAL   Nat. Genet. 1 (1), 72-75 (1992)
   PUBMED   1338766
REFERENCE   9  (residues 1 to 1306)
  AUTHORS   Ehlers MR and Riordan JF.
  TITLE     Angiotensin-converting enzyme: zinc- and inhibitor-binding
            stoichiometries of the somatic and testis isozymes
  JOURNAL   Biochemistry 30 (29), 7118-7126 (1991)
   PUBMED   1649623
REFERENCE   10 (residues 1 to 1306)
  AUTHORS   Sancho,J., Re,R., Burton,J., Barger,A.C. and Haber,E.
  TITLE     The role of the renin-angiotensin-aldosterone system in
            cardiovascular homeostasis in normal human subjects
  JOURNAL   Circulation 53 (3), 400-405 (1976)
   PUBMED   174834
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK296566.1, AB208971.1 and
            AC113554.9.
            
            Summary: This gene encodes an enzyme involved in catalyzing the
            conversion of angiotensin I into a physiologically active peptide
            angiotensin II. Angiotensin II is a potent vasopressor and
            aldosterone-stimulating peptide that controls blood pressure and
            fluid-electrolyte balance. This enzyme plays a key role in the
            renin-angiotensin system. Many studies have associated the presence
            or absence of a 287 bp Alu repeat element in this gene with the
            levels of circulating enzyme or cardiovascular pathophysiologies.
            Multiple alternatively spliced transcript variants encoding
            different isoforms have been identified, and two most abundant
            spliced variants encode the somatic form and the testicular form,
            respectively, that are equally active. [provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (1), also known as the endothelial
            or somatic form, represents the longest transcript and encodes the
            longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04144.1, AB208971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1306
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     Protein         1..1306
                     /product="angiotensin-converting enzyme isoform 1
                     precursor"
                     /EC_number="3.4.15.1"
                     /note="kininase II; CD143 antigen; angiotensin converting
                     enzyme, somatic isoform; peptidase P; carboxycathepsin;
                     dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase
                     I; angiotensin I converting enzyme (peptidyl-dipeptidase
                     A) 1"
                     /calculated_mol_wt=146830
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2904
     variation       1
                     /replace="k"
                     /db_xref="dbSNP:1005792910"
     variation       1
                     /replace="l"
                     /db_xref="dbSNP:1262893315"
     variation       2
                     /replace="e"
                     /db_xref="dbSNP:558593002"
     variation       2
                     /replace="g"
                     /db_xref="dbSNP:777383710"
     variation       5
                     /replace="a"
                     /db_xref="dbSNP:797045079"
     variation       5
                     /replace="w"
                     /db_xref="dbSNP:1296229818"
     variation       6
                     /replace="a"
                     /db_xref="dbSNP:1267076673"
     variation       6
                     /replace="g"
                     /db_xref="dbSNP:1242537847"
     variation       7
                     /replace="g"
                     /db_xref="dbSNP:1285068027"
     variation       7
                     /replace="l"
                     /db_xref="dbSNP:1451926480"
     variation       8
                     /replace="w"
                     /db_xref="dbSNP:1333116255"
     variation       9
                     /replace="e"
                     /db_xref="dbSNP:1223694748"
     variation       9
                     /replace="w"
                     /db_xref="dbSNP:1320210312"
     variation       10
                     /replace="p"
                     /db_xref="dbSNP:1244971538"
     variation       11
                     /replace="r"
                     /db_xref="dbSNP:1405957884"
     variation       13
                     /replace="-"
                     /db_xref="dbSNP:751352152"
     variation       13
                     /replace="-"
                     /db_xref="dbSNP:997225102"
     variation       13
                     /replace="p"
                     /db_xref="dbSNP:1187548350"
     variation       14
                     /replace="-"
                     /db_xref="dbSNP:1190879686"
     variation       14
                     /replace="l"
                     /db_xref="dbSNP:1477654795"
     variation       14
                     /replace="ll"
                     /db_xref="dbSNP:900084108"
     variation       14
                     /replace="p"
                     /db_xref="dbSNP:1207951348"
     variation       14
                     /replace="rgpglll"
                     /db_xref="dbSNP:1400363158"
     variation       15
                     /replace="-"
                     /db_xref="dbSNP:1245808974"
     variation       15
                     /replace="l"
                     /db_xref="dbSNP:1355518990"
     variation       15
                     /replace="p"
                     /db_xref="dbSNP:1110991"
     variation       15
                     /replace="s"
                     /db_xref="dbSNP:1193133040"
     variation       16
                     /replace="-"
                     /db_xref="dbSNP:983649759"
     variation       16
                     /replace="p"
                     /db_xref="dbSNP:1352305726"
     variation       17
                     /replace="-"
                     /db_xref="dbSNP:767132000"
     variation       17
                     /replace="p"
                     /db_xref="dbSNP:1297066077"
     variation       17
                     /replace="q"
                     /db_xref="dbSNP:1441805434"
     variation       18
                     /replace="pl"
                     /db_xref="dbSNP:532691783"
     variation       18
                     /replace="pl"
                     /db_xref="dbSNP:886053218"
     variation       19
                     /replace="l"
                     /db_xref="dbSNP:1384710532"
     variation       19
                     /replace="p"
                     /db_xref="dbSNP:1157043147"
     variation       20
                     /replace="s"
                     /db_xref="dbSNP:752411292"
     variation       20
                     /replace="w"
                     /db_xref="dbSNP:770640756"
     variation       21
                     /replace="-"
                     /db_xref="dbSNP:1321632628"
     variation       21
                     /replace="l"
                     /db_xref="dbSNP:1348709880"
     variation       22
                     /replace="l"
                     /db_xref="dbSNP:1371697204"
     variation       23
                     /replace="p"
                     /db_xref="dbSNP:1309413856"
     variation       23
                     /replace="s"
                     /db_xref="dbSNP:1288779128"
     variation       24
                     /replace="-"
                     /db_xref="dbSNP:1440772953"
     variation       24
                     /replace="llllpp"
                     /db_xref="dbSNP:1437482955"
     variation       24
                     /replace="p"
                     /db_xref="dbSNP:1378411648"
     variation       25
                     /replace="*"
                     /db_xref="dbSNP:1237545952"
     variation       25
                     /replace="l"
                     /db_xref="dbSNP:968327653"
     variation       26
                     /replace="p"
                     /db_xref="dbSNP:1356599370"
     variation       27
                     /replace="a"
                     /db_xref="dbSNP:1287432671"
     variation       27
                     /replace="g"
                     /db_xref="dbSNP:774092241"
     variation       28
                     /replace="l"
                     /db_xref="dbSNP:746237814"
     variation       29
                     /replace="a"
                     /db_xref="dbSNP:772630581"
     mat_peptide     30..1306
                     /product="angiotensin-converting enzyme isoform 1"
                     /calculated_mol_wt=146830
     Region          30..630
                     /region_name="Peptidase M2 1"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P12821.1)"
     variation       30
                     /replace="f"
                     /db_xref="dbSNP:1450600177"
     variation       30
                     /replace="l"
                     /db_xref="dbSNP:1238903566"
     variation       30
                     /replace="s"
                     /db_xref="dbSNP:1196105733"
     variation       31
                     /replace="d"
                     /db_xref="dbSNP:1200169472"
     variation       32
                     /replace="p"
                     /db_xref="dbSNP:1481921937"
     variation       32
                     /replace="t"
                     /db_xref="dbSNP:1395554180"
     variation       33
                     /replace="r"
                     /db_xref="dbSNP:1363496774"
     variation       34
                     /replace="c"
                     /db_xref="dbSNP:1459096726"
     variation       34
                     /replace="l"
                     /db_xref="dbSNP:1165401040"
     variation       34
                     /replace="l"
                     /db_xref="dbSNP:775982372"
     variation       36
                     /replace="l"
                     /db_xref="dbSNP:769008922"
     variation       36
                     /replace="p"
                     /db_xref="dbSNP:776799364"
     variation       36
                     /replace="s"
                     /db_xref="dbSNP:761292178"
     variation       37
                     /replace="d"
                     /db_xref="dbSNP:1444014388"
     variation       37
                     /replace="r"
                     /db_xref="dbSNP:1401848309"
     variation       38
                     /replace="s"
                     /db_xref="dbSNP:1327600431"
     Region          40..623
                     /region_name="Peptidase_M2"
                     /note="Angiotensin-converting enzyme; pfam01401"
                     /db_xref="CDD:279709"
     variation       41
                     /replace="t"
                     /db_xref="dbSNP:926499615"
     variation       41
                     /replace="v"
                     /db_xref="dbSNP:868524073"
     variation       42
                     /replace="e"
                     /db_xref="dbSNP:1188476738"
     variation       42
                     /replace="n"
                     /db_xref="dbSNP:376354160"
     variation       43
                     /replace="a"
                     /db_xref="dbSNP:1310330954"
     variation       43
                     /replace="e"
                     /db_xref="dbSNP:1333836318"
     variation       44
                     /replace="a"
                     /db_xref="dbSNP:1437897719"
     variation       44
                     /replace="t"
                     /db_xref="dbSNP:765456530"
     variation       44
                     /replace="v"
                     /db_xref="dbSNP:1259851229"
     variation       45
                     /replace="a"
                     /db_xref="dbSNP:763151946"
     variation       45
                     /replace="r"
                     /db_xref="dbSNP:750712925"
     variation       46
                     /replace="t"
                     /db_xref="dbSNP:1156835126"
     variation       47
                     /replace="r"
                     /db_xref="dbSNP:767353320"
     variation       49
                     /replace="l"
                     /db_xref="dbSNP:752407759"
     variation       50
                     /replace="e"
                     /db_xref="dbSNP:866071512"
     variation       50
                     /replace="t"
                     /db_xref="dbSNP:1412092470"
     variation       51
                     /replace="*"
                     /db_xref="dbSNP:1184203291"
     variation       52
                     /replace="c"
                     /db_xref="dbSNP:756108093"
     variation       52
                     /replace="n"
                     /db_xref="dbSNP:777523880"
     variation       52
                     /replace="q"
                     /db_xref="dbSNP:1189819056"
     variation       52
                     /replace="r"
                     /db_xref="dbSNP:368265670"
     variation       53
                     /replace="c"
                     /db_xref="dbSNP:991760634"
     variation       54
                     /replace="s"
                     /db_xref="dbSNP:756763242"
     variation       55
                     /replace="f"
                     /db_xref="dbSNP:886053219"
     variation       56
                     /replace="r"
                     /db_xref="dbSNP:868605010"
     variation       57
                     /replace="a"
                     /db_xref="dbSNP:1402236637"
     variation       58
                     /replace="k"
                     /db_xref="dbSNP:866105888"
     variation       59
                     /replace="*"
                     /db_xref="dbSNP:868134438"
     variation       59
                     /replace="q"
                     /db_xref="dbSNP:147912715"
     variation       60
                     /replace="a"
                     /db_xref="dbSNP:1279850136"
     variation       60
                     /replace="l"
                     /db_xref="dbSNP:1400442990"
     variation       60
                     /replace="v"
                     /db_xref="dbSNP:1338383822"
     variation       61
                     /replace="l"
                     /db_xref="dbSNP:929042659"
     variation       61
                     /replace="q"
                     /db_xref="dbSNP:745572589"
     variation       62
                     /replace="f"
                     /db_xref="dbSNP:771828535"
     variation       62
                     /replace="s"
                     /db_xref="dbSNP:1345758652"
     variation       63
                     /replace="*"
                     /db_xref="dbSNP:1278390159"
     variation       63
                     /replace="q"
                     /db_xref="dbSNP:780601919"
     variation       63
                     /replace="r"
                     /db_xref="dbSNP:868424949"
     variation       64
                     /replace="g"
                     /db_xref="dbSNP:747292160"
     variation       64
                     /replace="n"
                     /db_xref="dbSNP:769225220"
     variation       65
                     /replace="m"
                     /db_xref="dbSNP:776943620"
     variation       65
                     /replace="v"
                     /db_xref="dbSNP:1047503443"
     variation       66
                     /replace="t"
                     /db_xref="dbSNP:1450630173"
     variation       66
                     /replace="v"
                     /db_xref="dbSNP:1377707308"
     variation       67
                     /replace="g"
                     /db_xref="dbSNP:887280103"
     variation       67
                     /replace="t"
                     /db_xref="dbSNP:868323704"
     variation       68
                     /replace="i"
                     /db_xref="dbSNP:1331734032"
     variation       68
                     /replace="r"
                     /db_xref="dbSNP:1170287329"
     variation       69
                     /replace="c"
                     /db_xref="dbSNP:867394500"
     variation       69
                     /replace="l"
                     /db_xref="dbSNP:867174380"
     variation       69
                     /replace="r"
                     /db_xref="dbSNP:1374541007"
     variation       70
                     /replace="a"
                     /db_xref="dbSNP:769922375"
     variation       70
                     /replace="v"
                     /db_xref="dbSNP:372565955"
     variation       71
                     /replace="d"
                     /db_xref="dbSNP:773257897"
     variation       71
                     /replace="q"
                     /db_xref="dbSNP:766548114"
     variation       72
                     /replace="y"
                     /db_xref="dbSNP:752559637"
     variation       74
                     /replace="d"
                     /db_xref="dbSNP:1331766879"
     variation       74
                     /replace="n"
                     /db_xref="dbSNP:760330379"
     variation       74
                     /replace="s"
                     /db_xref="dbSNP:1235548322"
     variation       75
                     /replace="f"
                     /db_xref="dbSNP:375602836"
     variation       76
                     /replace="s"
                     /db_xref="dbSNP:1465491488"
     variation       76
                     /replace="t"
                     /db_xref="dbSNP:753783787"
     variation       77
                     /replace="a"
                     /db_xref="dbSNP:184457276"
     variation       77
                     /replace="t"
                     /db_xref="dbSNP:867626302"
     variation       78
                     /replace="e"
                     /db_xref="dbSNP:1377377204"
     variation       78
                     /replace="q"
                     /db_xref="dbSNP:778615098"
     variation       79
                     /replace="h"
                     /db_xref="dbSNP:1436341380"
     variation       79
                     /replace="t"
                     /db_xref="dbSNP:749921316"
     variation       80
                     /replace="a"
                     /db_xref="dbSNP:370200820"
     variation       81
                     /replace="g"
                     /db_xref="dbSNP:1435418712"
     variation       81
                     /replace="k"
                     /db_xref="dbSNP:779520756"
     variation       82
                     /replace="p"
                     /db_xref="dbSNP:997125723"
     variation       83
                     /replace="h"
                     /db_xref="dbSNP:747410284"
     variation       83
                     /replace="k"
                     /db_xref="dbSNP:1344103805"
     variation       84
                     /replace="k"
                     /db_xref="dbSNP:1345164089"
     variation       85
                     /replace="k"
                     /db_xref="dbSNP:150382846"
     variation       86
                     /replace="a"
                     /db_xref="dbSNP:773215584"
     variation       87
                     /replace="a"
                     /db_xref="dbSNP:1368094472"
     variation       87
                     /replace="s"
                     /db_xref="dbSNP:1440389747"
     variation       88
                     /replace="l"
                     /db_xref="dbSNP:762976911"
     variation       89
                     /replace="h"
                     /db_xref="dbSNP:765857431"
     variation       90
                     /replace="g"
                     /db_xref="dbSNP:751050925"
     variation       90
                     /replace="n"
                     /db_xref="dbSNP:1221928144"
     variation       90
                     /replace="s"
                     /db_xref="dbSNP:754618480"
     variation       91
                     /replace="e"
                     /db_xref="dbSNP:1414717313"
     variation       92
                     /replace="g"
                     /db_xref="dbSNP:767149889"
     variation       93
                     /replace="l"
                     /db_xref="dbSNP:1407901466"
     variation       93
                     /replace="v"
                     /db_xref="dbSNP:1223622664"
     variation       94
                     /replace="v"
                     /db_xref="dbSNP:753078890"
     variation       96
                     /replace="a"
                     /db_xref="dbSNP:778109111"
     variation       96
                     /replace="p"
                     /db_xref="dbSNP:756407366"
     variation       96
                     /replace="v"
                     /db_xref="dbSNP:1193074438"
     variation       97
                     /replace="c"
                     /db_xref="dbSNP:1471264963"
     variation       99
                     /replace="e"
                     /db_xref="dbSNP:749853877"
     variation       100
                     /replace="e"
                     /db_xref="dbSNP:1407660027"
     variation       101
                     /replace="t"
                     /db_xref="dbSNP:757757495"
     variation       102
                     /replace="k"
                     /db_xref="dbSNP:778896429"
     variation       102
                     /replace="q"
                     /db_xref="dbSNP:1167640238"
     variation       103
                     /replace="d"
                     /db_xref="dbSNP:1439594637"
     variation       104
                     /replace="l"
                     /db_xref="dbSNP:1331429699"
     variation       105
                     /replace="c"
                     /db_xref="dbSNP:1220739409"
     variation       105
                     /replace="y"
                     /db_xref="dbSNP:745917371"
     variation       106
                     /replace="g"
                     /db_xref="dbSNP:1279075366"
     variation       106
                     /replace="q"
                     /db_xref="dbSNP:912523740"
     variation       107
                     /replace="p"
                     /db_xref="dbSNP:1278761839"
     variation       107
                     /replace="r"
                     /db_xref="dbSNP:772201818"
     variation       110
                     /replace="h"
                     /db_xref="dbSNP:780364983"
     variation       112
                     /replace="f"
                     /db_xref="dbSNP:1235076329"
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     variation       199
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     variation       254
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     variation       255
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     variation       263
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     variation       268
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     variation       268
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     variation       298
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     variation       299
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     variation       302
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     variation       304
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     variation       305
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     variation       305
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     variation       306
                     /replace="l"
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     variation       306
                     /replace="r"
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     variation       307
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     variation       307
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     variation       308
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     variation       309
                     /replace="a"
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     variation       309
                     /replace="i"
                     /db_xref="dbSNP:755789019"
     variation       309
                     /replace="t"
                     /db_xref="dbSNP:150754995"
     variation       310
                     /replace="g"
                     /db_xref="dbSNP:144137849"
     variation       310
                     /replace="n"
                     /db_xref="dbSNP:774789681"
     variation       310
                     /replace="s"
                     /db_xref="dbSNP:1386840090"
     variation       311
                     /replace="s"
                     /db_xref="dbSNP:746377185"
     variation       312
                     /replace="t"
                     /db_xref="dbSNP:201588518"
     variation       312
                     /replace="v"
                     /db_xref="dbSNP:367998749"
     variation       315
                     /replace="*"
                     /db_xref="dbSNP:760913528"
     variation       316
                     /replace="c"
                     /db_xref="dbSNP:561813163"
     variation       317
                     /replace="*"
                     /db_xref="dbSNP:1414333467"
     variation       318
                     /replace="n"
                     /db_xref="dbSNP:750747849"
     variation       319
                     /replace="a"
                     /db_xref="dbSNP:768781070"
     variation       319
                     /replace="s"
                     /db_xref="dbSNP:34126458"
     variation       320
                     /replace="a"
                     /db_xref="dbSNP:1384833654"
     variation       320
                     /replace="m"
                     /db_xref="dbSNP:139137100"
     variation       320
                     /replace="t"
                     /db_xref="dbSNP:547724686"
     variation       321
                     /replace="h"
                     /db_xref="dbSNP:770009289"
     variation       322
                     /replace="v"
                     /db_xref="dbSNP:1391141938"
     variation       324
                     /replace="q"
                     /db_xref="dbSNP:374029266"
     variation       324
                     /replace="w"
                     /db_xref="dbSNP:35141294"
     variation       325
                     /replace="m"
                     /db_xref="dbSNP:771762179"
     variation       325
                     /replace="v"
                     /db_xref="dbSNP:61738840"
     variation       326
                     /replace="q"
                     /db_xref="dbSNP:1474671878"
     variation       326
                     /replace="t"
                     /db_xref="dbSNP:1273653682"
     variation       328
                     /replace="e"
                     /db_xref="dbSNP:192205417"
     variation       328
                     /replace="k"
                     /db_xref="dbSNP:992848550"
     variation       330
                     /replace="l"
                     /db_xref="dbSNP:763740829"
     variation       331
                     /replace="i"
                     /db_xref="dbSNP:1444816395"
     variation       332
                     /replace="s"
                     /db_xref="dbSNP:767127845"
     variation       333
                     /replace="l"
                     /db_xref="dbSNP:983222441"
     variation       333
                     /replace="q"
                     /db_xref="dbSNP:761390621"
     variation       334
                     /replace="e"
                     /db_xref="dbSNP:1434755052"
     variation       334
                     /replace="q"
                     /db_xref="dbSNP:1336871330"
     variation       337
                     /replace="a"
                     /db_xref="dbSNP:764882826"
     variation       337
                     /replace="l"
                     /db_xref="dbSNP:750754792"
     variation       337
                     /replace="p"
                     /db_xref="dbSNP:758862141"
     variation       338
                     /replace="c"
                     /db_xref="dbSNP:1196439789"
     variation       338
                     /replace="i"
                     /db_xref="dbSNP:1422578392"
     variation       338
                     /replace="v"
                     /db_xref="dbSNP:1414191617"
     variation       339
                     /replace="s"
                     /db_xref="dbSNP:1455859263"
     variation       340
                     /replace="p"
                     /db_xref="dbSNP:3730026"
     variation       341
                     /replace="k"
                     /db_xref="dbSNP:201456235"
     variation       342
                     /replace="f"
                     /db_xref="dbSNP:1321931007"
     variation       342
                     /replace="s"
                     /db_xref="dbSNP:755446607"
     variation       343
                     /replace="*"
                     /db_xref="dbSNP:200225958"
     variation       346
                     /replace="l"
                     /db_xref="dbSNP:781272495"
     variation       346
                     /replace="r"
                     /db_xref="dbSNP:1331062614"
     variation       346
                     /replace="s"
                     /db_xref="dbSNP:34680431"
     variation       348
                     /replace="p"
                     /db_xref="dbSNP:769913687"
     variation       349
                     /replace="a"
                     /db_xref="dbSNP:778126198"
     variation       351
                     /replace="l"
                     /db_xref="dbSNP:2229839"
     variation       351
                     /replace="p"
                     /db_xref="dbSNP:771954829"
     variation       352
                     /replace="a"
                     /db_xref="dbSNP:369739909"
     variation       353
                     /replace="d"
                     /db_xref="dbSNP:933147418"
     variation       353
                     /replace="n"
                     /db_xref="dbSNP:148193919"
     variation       354
                     /replace="g"
                     /db_xref="dbSNP:1052121324"
     variation       354
                     /replace="r"
                     /db_xref="dbSNP:56394458"
     variation       355
                     /replace="q"
                     /db_xref="dbSNP:761322765"
     variation       355
                     /replace="r"
                     /db_xref="dbSNP:892186243"
     variation       355
                     /replace="w"
                     /db_xref="dbSNP:776297611"
     variation       356
                     /replace="k"
                     /db_xref="dbSNP:553718986"
     variation       357
                     /replace="m"
                     /db_xref="dbSNP:1273328602"
     variation       358
                     /replace="-"
                     /db_xref="dbSNP:770842341"
     variation       358
                     /replace="l"
                     /db_xref="dbSNP:764651696"
     variation       359
                     /replace="a"
                     /db_xref="dbSNP:774181017"
     variation       359
                     /replace="c"
                     /db_xref="dbSNP:750150414"
     Site            order(360..362,390..391,394,418,464,518..520,525,527,530)
                     /site_type="active"
                     /db_xref="CDD:188999"
     variation       360
                     /replace="h"
                     /db_xref="dbSNP:766770855"
     variation       360
                     /replace="y"
                     /db_xref="dbSNP:199690936"
     variation       361
                     /replace="t"
                     /db_xref="dbSNP:546455400"
     variation       362
                     /replace="s"
                     /db_xref="dbSNP:151281288"
     variation       362
                     /replace="t"
                     /db_xref="dbSNP:1274888100"
     variation       362
                     /replace="w"
                     /db_xref="dbSNP:142328237"
     variation       363
                     /replace="a"
                     /db_xref="dbSNP:756273416"
     variation       363
                     /replace="p"
                     /db_xref="dbSNP:1443267419"
     variation       363
                     /replace="v"
                     /db_xref="dbSNP:370491569"
     variation       364
                     /replace="c"
                     /db_xref="dbSNP:1325867826"
     variation       365
                     /replace="d"
                     /db_xref="dbSNP:1257546479"
     variation       366
                     /replace="f"
                     /db_xref="dbSNP:114488574"
     variation       367
                     /replace="c"
                     /db_xref="dbSNP:757510589"
     variation       368
                     /replace="k"
                     /db_xref="dbSNP:1482676646"
     variation       368
                     /replace="s"
                     /db_xref="dbSNP:369713789"
     variation       369
                     /replace="g"
                     /db_xref="dbSNP:373357172"
     variation       370
                     /replace="r"
                     /db_xref="dbSNP:1176719016"
     variation       373
                     /replace="k"
                     /db_xref="dbSNP:904500063"
     variation       373
                     /replace="s"
                     /db_xref="dbSNP:189243320"
     variation       375
                     /replace="r"
                     /db_xref="dbSNP:778168348"
     variation       376
                     /replace="q"
                     /db_xref="dbSNP:1190121193"
     variation       379
                     /replace="q"
                     /db_xref="dbSNP:13306085"
     variation       379
                     /replace="w"
                     /db_xref="dbSNP:750724647"
     variation       380
                     /replace="d"
                     /db_xref="dbSNP:752385390"
     variation       380
                     /replace="v"
                     /db_xref="dbSNP:996995671"
     variation       381
                     /replace="m"
                     /db_xref="dbSNP:150466411"
     variation       381
                     /replace="t"
                     /db_xref="dbSNP:777638081"
     variation       382
                     /replace="i"
                     /db_xref="dbSNP:770475936"
     variation       382
                     /replace="l"
                     /db_xref="dbSNP:370890237"
     variation       383
                     /replace="g"
                     /db_xref="dbSNP:374899854"
     variation       387
                     /replace="a"
                     /db_xref="dbSNP:1347736201"
     variation       388
                     /replace="v"
                     /db_xref="dbSNP:1411980064"
     variation       389
                     /replace="q"
                     /db_xref="dbSNP:1405848294"
     Site            order(390,394,418)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188999"
     variation       391
                     /replace="e"
                     /db_xref="dbSNP:745548368"
     variation       392
                     /replace="t"
                     /db_xref="dbSNP:138418851"
     variation       394
                     /replace="r"
                     /db_xref="dbSNP:775932125"
     variation       395
                     /replace="m"
                     /db_xref="dbSNP:760885341"
     variation       396
                     /replace="*"
                     /db_xref="dbSNP:769063911"
     variation       400
                     /replace="k"
                     /db_xref="dbSNP:771386010"
     variation       400
                     /replace="q"
                     /db_xref="dbSNP:374342422"
     variation       400
                     /replace="r"
                     /db_xref="dbSNP:548450663"
     variation       401
                     /replace="c"
                     /db_xref="dbSNP:765449601"
     variation       402
                     /replace="k"
                     /db_xref="dbSNP:568223557"
     variation       402
                     /replace="m"
                     /db_xref="dbSNP:1329993082"
     variation       403
                     /replace="a"
                     /db_xref="dbSNP:763292265"
     variation       404
                     /replace="v"
                     /db_xref="dbSNP:1229622121"
     variation       405
                     /replace="p"
                     /db_xref="dbSNP:4309"
     variation       405
                     /replace="r"
                     /db_xref="dbSNP:766454164"
     variation       406
                     /replace="i"
                     /db_xref="dbSNP:201117983"
     variation       407
                     /replace="f"
                     /db_xref="dbSNP:570424963"
     variation       407
                     /replace="s"
                     /db_xref="dbSNP:903738622"
     variation       408
                     /replace="l"
                     /db_xref="dbSNP:1253155590"
     variation       409
                     /replace="c"
                     /db_xref="dbSNP:199746395"
     variation       409
                     /replace="l"
                     /db_xref="dbSNP:371833006"
     variation       409
                     /replace="r"
                     /db_xref="dbSNP:373568007"
     variation       410
                     /replace="p"
                     /db_xref="dbSNP:145172277"
     variation       410
                     /replace="r"
                     /db_xref="dbSNP:1166655480"
     variation       410
                     /replace="w"
                     /db_xref="dbSNP:370836540"
     variation       411
                     /replace="r"
                     /db_xref="dbSNP:1347844823"
     variation       412
                     /replace="a"
                     /db_xref="dbSNP:746663455"
     variation       412
                     /replace="g"
                     /db_xref="dbSNP:759192800"
     variation       412
                     /replace="s"
                     /db_xref="dbSNP:779643154"
     variation       413
                     /replace="k"
                     /db_xref="dbSNP:1352223425"
     variation       413
                     /replace="s"
                     /db_xref="dbSNP:1308632106"
     variation       414
                     /replace="p"
                     /db_xref="dbSNP:138521921"
     variation       415
                     /replace="d"
                     /db_xref="dbSNP:1350271986"
     variation       415
                     /replace="s"
                     /db_xref="dbSNP:149252911"
     variation       417
                     /replace="r"
                     /db_xref="dbSNP:1229041283"
     variation       419
                     /replace="s"
                     /db_xref="dbSNP:1311367540"
     variation       420
                     /replace="t"
                     /db_xref="dbSNP:144494842"
     variation       422
                     /replace="d"
                     /db_xref="dbSNP:908511692"
     variation       423
                     /replace="m"
                     /db_xref="dbSNP:148018765"
     variation       423
                     /replace="v"
                     /db_xref="dbSNP:941378818"
     variation       425
                     /replace="a"
                     /db_xref="dbSNP:143321044"
     variation       425
                     /replace="v"
                     /db_xref="dbSNP:372626836"
     variation       426
                     /replace="r"
                     /db_xref="dbSNP:1295075641"
     variation       427
                     /replace="l"
                     /db_xref="dbSNP:1484293906"
     variation       427
                     /replace="s"
                     /db_xref="dbSNP:541236264"
     variation       428
                     /replace="g"
                     /db_xref="dbSNP:774484341"
     variation       428
                     /replace="l"
                     /db_xref="dbSNP:1368163348"
     variation       429
                     /replace="f"
                     /db_xref="dbSNP:1430341434"
     variation       431
                     /replace="p"
                     /db_xref="dbSNP:759771130"
     variation       432
                     /replace="q"
                     /db_xref="dbSNP:1388420671"
     variation       433
                     /replace="r"
                     /db_xref="dbSNP:763905584"
     variation       433
                     /replace="y"
                     /db_xref="dbSNP:1183298190"
     variation       434
                     /replace="l"
                     /db_xref="dbSNP:1297827633"
     variation       434
                     /replace="v"
                     /db_xref="dbSNP:753578845"
     variation       435
                     /replace="h"
                     /db_xref="dbSNP:912585098"
     variation       435
                     /replace="l"
                     /db_xref="dbSNP:757195769"
     variation       436
                     /replace="*"
                     /db_xref="dbSNP:1427700343"
     variation       436
                     /replace="k"
                     /db_xref="dbSNP:1335306599"
     variation       436
                     /replace="r"
                     /db_xref="dbSNP:765088731"
     variation       437
                     /replace="i"
                     /db_xref="dbSNP:144657113"
     variation       438
                     /replace="d"
                     /db_xref="dbSNP:757908100"
     variation       438
                     /replace="g"
                     /db_xref="dbSNP:779596083"
     variation       438
                     /replace="s"
                     /db_xref="dbSNP:1051245483"
     variation       439
                     /replace="l"
                     /db_xref="dbSNP:140529617"
     variation       440
                     /replace="l"
                     /db_xref="dbSNP:199697957"
     variation       440
                     /replace="p"
                     /db_xref="dbSNP:387906576"
     variation       440
                     /replace="r"
                     /db_xref="dbSNP:748465912"
     variation       441
                     /replace="d"
                     /db_xref="dbSNP:773913073"
     variation       441
                     /replace="n"
                     /db_xref="dbSNP:770430455"
     variation       442
                     /replace="c"
                     /db_xref="dbSNP:749779360"
     variation       442
                     /replace="p"
                     /db_xref="dbSNP:35865660"
     variation       442
                     /replace="r"
                     /db_xref="dbSNP:759696556"
     variation       442
                     /replace="v"
                     /db_xref="dbSNP:1442562714"
     variation       443
                     /replace="v"
                     /db_xref="dbSNP:1222899075"
     variation       444
                     /replace="t"
                     /db_xref="dbSNP:767666140"
     variation       445
                     /replace="d"
                     /db_xref="dbSNP:776411660"
     variation       445
                     /replace="s"
                     /db_xref="dbSNP:1167328695"
     variation       447
                     /replace="a"
                     /db_xref="dbSNP:761659396"
     variation       447
                     /replace="m"
                     /db_xref="dbSNP:746314800"
     variation       447
                     /replace="t"
                     /db_xref="dbSNP:34241302"
     variation       448
                     /replace="e"
                     /db_xref="dbSNP:1289663597"
     variation       449
                     /replace="t"
                     /db_xref="dbSNP:373076770"
     variation       450
                     /replace="n"
                     /db_xref="dbSNP:185115105"
     variation       451
                     /replace="t"
                     /db_xref="dbSNP:1158360384"
     variation       451
                     /replace="v"
                     /db_xref="dbSNP:1401663578"
     variation       454
                     /replace="*"
                     /db_xref="dbSNP:1404415405"
     variation       456
                     /replace="k"
                     /db_xref="dbSNP:746343783"
     variation       458
                     /replace="a"
                     /db_xref="dbSNP:1301877423"
     variation       458
                     /replace="v"
                     /db_xref="dbSNP:1388880245"
     variation       459
                     /replace="l"
                     /db_xref="dbSNP:772192946"
     variation       462
                     /replace="f"
                     /db_xref="dbSNP:1370566904"
     variation       462
                     /replace="n"
                     /db_xref="dbSNP:1289633744"
     variation       462
                     /replace="n"
                     /db_xref="dbSNP:1409924291"
     variation       463
                     /replace="a"
                     /db_xref="dbSNP:750404093"
     variation       464
                     /replace="s"
                     /db_xref="dbSNP:753436653"
     variation       465
                     /replace="l"
                     /db_xref="dbSNP:780081292"
     variation       468
                     /replace="c"
                     /db_xref="dbSNP:1170017440"
     variation       468
                     /replace="g"
                     /db_xref="dbSNP:747266293"
     variation       469
                     /replace="y"
                     /db_xref="dbSNP:1358284999"
     variation       471
                     /replace="m"
                     /db_xref="dbSNP:768818130"
     variation       473
                     /replace="q"
                     /db_xref="dbSNP:921227559"
     variation       474
                     /replace="*"
                     /db_xref="dbSNP:762742726"
     variation       474
                     /replace="r"
                     /db_xref="dbSNP:772897915"
     variation       475
                     /replace="c"
                     /db_xref="dbSNP:770628079"
     variation       475
                     /replace="l"
                     /db_xref="dbSNP:774394975"
     variation       475
                     /replace="r"
                     /db_xref="dbSNP:767165701"
     variation       477
                     /replace="e"
                     /db_xref="dbSNP:986987823"
     variation       477
                     /replace="g"
                     /db_xref="dbSNP:752204662"
     variation       478
                     /replace="g"
                     /db_xref="dbSNP:1246593224"
     variation       478
                     /replace="s"
                     /db_xref="dbSNP:1369270202"
     variation       479
                     /replace="f"
                     /db_xref="dbSNP:375631324"
     variation       479
                     /replace="v"
                     /db_xref="dbSNP:760413658"
     variation       480
                     /replace="n"
                     /db_xref="dbSNP:886053220"
     variation       482
                     /replace="c"
                     /db_xref="dbSNP:201540553"
     variation       482
                     /replace="l"
                     /db_xref="dbSNP:757694144"
     variation       483
                     /replace="t"
                     /db_xref="dbSNP:201780696"
     variation       484
                     /replace="p"
                     /db_xref="dbSNP:758865144"
     variation       484
                     /replace="r"
                     /db_xref="dbSNP:1365864797"
     variation       485
                     /replace="a"
                     /db_xref="dbSNP:202178737"
     variation       485
                     /replace="r"
                     /db_xref="dbSNP:28730839"
     variation       486
                     /replace="f"
                     /db_xref="dbSNP:748305912"
     variation       486
                     /replace="f"
                     /db_xref="dbSNP:758933315"
     variation       487
                     /replace="c"
                     /db_xref="dbSNP:149784122"
     variation       487
                     /replace="h"
                     /db_xref="dbSNP:376430907"
     variation       488
                     /replace="s"
                     /db_xref="dbSNP:948392443"
     variation       489
                     /replace="d"
                     /db_xref="dbSNP:745820101"
     variation       489
                     /replace="k"
                     /db_xref="dbSNP:145755731"
     variation       490
                     /replace="f"
                     /db_xref="dbSNP:775141617"
     variation       491
                     /replace="e"
                     /db_xref="dbSNP:1254289491"
     variation       491
                     /replace="e"
                     /db_xref="dbSNP:1257147672"
     variation       491
                     /replace="n"
                     /db_xref="dbSNP:371335496"
     variation       492
                     /replace="*"
                     /db_xref="dbSNP:1446625916"
     variation       493
                     /replace="c"
                     /db_xref="dbSNP:1182135727"
     variation       494
                     /replace="d"
                     /db_xref="dbSNP:760325775"
     variation       495
                     /replace="f"
                     /db_xref="dbSNP:374169715"
     variation       496
                     /replace="*"
                     /db_xref="dbSNP:397514688"
     variation       496
                     /replace="q"
                     /db_xref="dbSNP:761345398"
     variation       497
                     /replace="a"
                     /db_xref="dbSNP:766717973"
     variation       497
                     /replace="t"
                     /db_xref="dbSNP:1303300504"
     variation       498
                     /replace="r"
                     /db_xref="dbSNP:752110462"
     variation       499
                     /replace="c"
                     /db_xref="dbSNP:779110765"
     variation       500
                     /replace="r"
                     /db_xref="dbSNP:1330033201"
     variation       500
                     /replace="r"
                     /db_xref="dbSNP:748348196"
     variation       501
                     /replace="e"
                     /db_xref="dbSNP:767656727"
     variation       501
                     /replace="g"
                     /db_xref="dbSNP:752661267"
     variation       501
                     /replace="r"
                     /db_xref="dbSNP:886053221"
     variation       503
                     /replace="c"
                     /db_xref="dbSNP:1036966443"
     variation       503
                     /replace="s"
                     /db_xref="dbSNP:1485835785"
     variation       504
                     /replace="l"
                     /db_xref="dbSNP:557514021"
     variation       504
                     /replace="s"
                     /db_xref="dbSNP:778204413"
     variation       505
                     /replace="-"
                     /db_xref="dbSNP:766909364"
     variation       505
                     /replace="a"
                     /db_xref="dbSNP:148943954"
     variation       506
                     /replace="i"
                     /db_xref="dbSNP:747001287"
     variation       507
                     /replace="a"
                     /db_xref="dbSNP:1385293426"
     variation       507
                     /replace="s"
                     /db_xref="dbSNP:1225189746"
     variation       507
                     /replace="t"
                     /db_xref="dbSNP:768430819"
     variation       508
                     /replace="*"
                     /db_xref="dbSNP:367797185"
     variation       508
                     /replace="q"
                     /db_xref="dbSNP:746397573"
     variation       509
                     /replace="d"
                     /db_xref="dbSNP:769290119"
     variation       509
                     /replace="n"
                     /db_xref="dbSNP:772691613"
     variation       510
                     /replace="k"
                     /db_xref="dbSNP:371544905"
     variation       511
                     /replace="a"
                     /db_xref="dbSNP:762574298"
     variation       511
                     /replace="t"
                     /db_xref="dbSNP:1379724938"
     variation       514
                     /replace="g"
                     /db_xref="dbSNP:889903750"
     variation       514
                     /replace="n"
                     /db_xref="dbSNP:201762720"
     variation       515
                     /replace="s"
                     /db_xref="dbSNP:144294634"
     variation       516
                     /replace="g"
                     /db_xref="dbSNP:1225625626"
     variation       519
                     /replace="f"
                     /db_xref="dbSNP:551950090"
     variation       520
                     /replace="h"
                     /db_xref="dbSNP:753240067"
     variation       520
                     /replace="n"
                     /db_xref="dbSNP:767844081"
     variation       520
                     /replace="r"
                     /db_xref="dbSNP:1222739179"
     variation       523
                     /replace="d"
                     /db_xref="dbSNP:1053930450"
     variation       523
                     /replace="s"
                     /db_xref="dbSNP:1195088899"
     variation       524
                     /replace="a"
                     /db_xref="dbSNP:12720746"
     variation       524
                     /replace="m"
                     /db_xref="dbSNP:1198635867"
     variation       525
                     /replace="a"
                     /db_xref="dbSNP:764244232"
     variation       525
                     /replace="i"
                     /db_xref="dbSNP:1251832995"
     variation       526
                     /replace="l"
                     /db_xref="dbSNP:867015748"
     variation       526
                     /replace="p"
                     /db_xref="dbSNP:1257516028"
     variation       526
                     /replace="s"
                     /db_xref="dbSNP:754150700"
     variation       527
                     /replace="c"
                     /db_xref="dbSNP:376323371"
     variation       529
                     /replace="s"
                     /db_xref="dbSNP:368074905"
     variation       530
                     /replace="c"
                     /db_xref="dbSNP:745506888"
     variation       531
                     /replace="c"
                     /db_xref="dbSNP:551801825"
     variation       533
                     /replace="s"
                     /db_xref="dbSNP:775881026"
     variation       534
                     /replace="l"
                     /db_xref="dbSNP:1390757637"
     variation       535
                     /replace="i"
                     /db_xref="dbSNP:1190471425"
     variation       535
                     /replace="v"
                     /db_xref="dbSNP:1205798243"
     variation       536
                     /replace="l"
                     /db_xref="dbSNP:1474278474"
     variation       537
                     /replace="*"
                     /db_xref="dbSNP:1460738029"
     variation       537
                     /replace="h"
                     /db_xref="dbSNP:868856670"
     variation       537
                     /replace="r"
                     /db_xref="dbSNP:762937072"
     variation       538
                     /replace="l"
                     /db_xref="dbSNP:769230286"
     variation       539
                     /replace="*"
                     /db_xref="dbSNP:1474365321"
     variation       540
                     /replace="f"
                     /db_xref="dbSNP:1489956918"
     variation       540
                     /replace="qf"
                     /db_xref="dbSNP:771053807"
     variation       541
                     /replace="r"
                     /db_xref="dbSNP:776858777"
     variation       542
                     /replace="g"
                     /db_xref="dbSNP:1453609198"
     variation       543
                     /replace="a"
                     /db_xref="dbSNP:141369597"
     variation       543
                     /replace="g"
                     /db_xref="dbSNP:765347178"
     variation       543
                     /replace="s"
                     /db_xref="dbSNP:762055246"
     variation       544
                     /replace="l"
                     /db_xref="dbSNP:752477733"
     variation       545
                     /replace="c"
                     /db_xref="dbSNP:531131955"
     variation       547
                     /replace="*"
                     /db_xref="dbSNP:1319345885"
     variation       549
                     /replace="d"
                     /db_xref="dbSNP:1328713530"
     variation       549
                     /replace="g"
                     /db_xref="dbSNP:199955602"
     variation       550
                     /replace="c"
                     /db_xref="dbSNP:753761783"
     variation       551
                     /replace="e"
                     /db_xref="dbSNP:1226852760"
     variation       552
                     /replace="d"
                     /db_xref="dbSNP:145152527"
     variation       552
                     /replace="s"
                     /db_xref="dbSNP:1339063327"
     variation       553
                     /replace="p"
                     /db_xref="dbSNP:1224782851"
     variation       554
                     /replace="l"
                     /db_xref="dbSNP:1436729410"
     variation       555
                     /replace="y"
                     /db_xref="dbSNP:778451287"
     variation       557
                     /replace="r"
                     /db_xref="dbSNP:1012505443"
     variation       558
                     /replace="d"
                     /db_xref="dbSNP:1322341940"
     variation       559
                     /replace="v"
                     /db_xref="dbSNP:1205538057"
     variation       560
                     /replace="c"
                     /db_xref="dbSNP:745536540"
     variation       561
                     /replace="q"
                     /db_xref="dbSNP:780299861"
     variation       561
                     /replace="w"
                     /db_xref="dbSNP:4314"
     variation       563
                     /replace="a"
                     /db_xref="dbSNP:747313119"
     variation       563
                     /replace="i"
                     /db_xref="dbSNP:769142434"
     variation       564
                     /replace="e"
                     /db_xref="dbSNP:1171059871"
     variation       564
                     /replace="k"
                     /db_xref="dbSNP:1201621622"
     variation       565
                     /replace="t"
                     /db_xref="dbSNP:777339023"
     variation       566
                     /replace="e"
                     /db_xref="dbSNP:769805183"
     variation       566
                     /replace="g"
                     /db_xref="dbSNP:1387667902"
     variation       566
                     /replace="r"
                     /db_xref="dbSNP:748643856"
     variation       567
                     /replace="t"
                     /db_xref="dbSNP:1399318948"
     variation       567
                     /replace="v"
                     /db_xref="dbSNP:1422455629"
     variation       569
                     /replace="l"
                     /db_xref="dbSNP:1406269654"
     variation       569
                     /replace="p"
                     /db_xref="dbSNP:773305413"
     variation       569
                     /replace="v"
                     /db_xref="dbSNP:1318295451"
     variation       570
                     /replace="q"
                     /db_xref="dbSNP:371599063"
     variation       570
                     /replace="r"
                     /db_xref="dbSNP:1393920320"
     variation       570
                     /replace="w"
                     /db_xref="dbSNP:567828872"
     variation       571
                     /replace="n"
                     /db_xref="dbSNP:777717910"
     variation       572
                     /replace="v"
                     /db_xref="dbSNP:1336956105"
     variation       573
                     /replace="l"
                     /db_xref="dbSNP:1384775197"
     variation       573
                     /replace="p"
                     /db_xref="dbSNP:1365063879"
     variation       576
                     /replace="s"
                     /db_xref="dbSNP:1004119034"
     variation       576
                     /replace="v"
                     /db_xref="dbSNP:1243492273"
     variation       577
                     /replace="p"
                     /db_xref="dbSNP:749450863"
     variation       577
                     /replace="s"
                     /db_xref="dbSNP:939614410"
     variation       578
                     /replace="s"
                     /db_xref="dbSNP:367659273"
     variation       579
                     /replace="r"
                     /db_xref="dbSNP:774604598"
     variation       580
                     /replace="l"
                     /db_xref="dbSNP:897870088"
     variation       580
                     /replace="t"
                     /db_xref="dbSNP:759719543"
     variation       581
                     /replace="*"
                     /db_xref="dbSNP:768467806"
     variation       581
                     /replace="c"
                     /db_xref="dbSNP:1337718181"
     variation       583
                     /replace="d"
                     /db_xref="dbSNP:1198303493"
     variation       585
                     /replace="l"
                     /db_xref="dbSNP:930634473"
     variation       585
                     /replace="p"
                     /db_xref="dbSNP:776358299"
     variation       586
                     /replace="e"
                     /db_xref="dbSNP:371414386"
     variation       586
                     /replace="r"
                     /db_xref="dbSNP:1489606366"
     variation       587
                     /replace="d"
                     /db_xref="dbSNP:765157268"
     variation       587
                     /replace="n"
                     /db_xref="dbSNP:1182072433"
     variation       588
                     /replace="t"
                     /db_xref="dbSNP:1171932485"
     variation       588
                     /replace="v"
                     /db_xref="dbSNP:1429588559"
     variation       589
                     /replace="v"
                     /db_xref="dbSNP:140086153"
     variation       590
                     /replace="d"
                     /db_xref="dbSNP:1176792351"
     variation       590
                     /replace="g"
                     /db_xref="dbSNP:765969966"
     variation       590
                     /replace="s"
                     /db_xref="dbSNP:762585402"
     variation       592
                     /replace="g"
                     /db_xref="dbSNP:12709426"
     variation       592
                     /replace="n"
                     /db_xref="dbSNP:1450198005"
     variation       594
                     /replace="p"
                     /db_xref="dbSNP:781708329"
     variation       595
                     /replace="d"
                     /db_xref="dbSNP:1488115483"
     variation       595
                     /replace="y"
                     /db_xref="dbSNP:753055168"
     variation       596
                     /replace="a"
                     /db_xref="dbSNP:566908400"
     variation       596
                     /replace="s"
                     /db_xref="dbSNP:530248886"
     variation       596
                     /replace="v"
                     /db_xref="dbSNP:546796175"
     variation       598
                     /replace="l"
                     /db_xref="dbSNP:759009903"
     variation       598
                     /replace="p"
                     /db_xref="dbSNP:137910205"
     variation       598
                     /replace="s"
                     /db_xref="dbSNP:988156346"
     variation       599
                     /replace="l"
                     /db_xref="dbSNP:746108090"
     variation       599
                     /replace="l"
                     /db_xref="dbSNP:772221735"
     variation       601
                     /replace="e"
                     /db_xref="dbSNP:1188841988"
     variation       601
                     /replace="k"
                     /db_xref="dbSNP:1466827500"
     variation       601
                     /replace="r"
                     /db_xref="dbSNP:776418026"
     variation       602
                     /replace="y"
                     /db_xref="dbSNP:1408772607"
     variation       603
                     /replace="i"
                     /db_xref="dbSNP:1178062715"
     variation       605
                     /replace="p"
                     /db_xref="dbSNP:1260255294"
     variation       607
                     /replace="i"
                     /db_xref="dbSNP:1477242406"
     variation       608
                     /replace="p"
                     /db_xref="dbSNP:1427973166"
     variation       608
                     /replace="q"
                     /db_xref="dbSNP:761737635"
     variation       609
                     /replace="*"
                     /db_xref="dbSNP:769466912"
     variation       609
                     /replace="r"
                     /db_xref="dbSNP:1430977899"
     variation       610
                     /replace="l"
                     /db_xref="dbSNP:1248281826"
     variation       612
                     /replace="a"
                     /db_xref="dbSNP:773255356"
     variation       613
                     /replace="*"
                     /db_xref="dbSNP:935167896"
     variation       614
                     /replace="n"
                     /db_xref="dbSNP:886053222"
     variation       615
                     /replace="q"
                     /db_xref="dbSNP:149476654"
     variation       616
                     /replace="*"
                     /db_xref="dbSNP:762769560"
     variation       617
                     /replace="h"
                     /db_xref="dbSNP:1455120932"
     variation       617
                     /replace="n"
                     /db_xref="dbSNP:773951841"
     variation       617
                     /replace="s"
                     /db_xref="dbSNP:372497513"
     variation       618
                     /replace="g"
                     /db_xref="dbSNP:767343744"
     variation       618
                     /replace="s"
                     /db_xref="dbSNP:111269527"
     variation       619
                     /replace="a"
                     /db_xref="dbSNP:1221968598"
     variation       619
                     /replace="e"
                     /db_xref="dbSNP:948029758"
     variation       619
                     /replace="k"
                     /db_xref="dbSNP:375452338"
     variation       621
                     /replace="l"
                     /db_xref="dbSNP:756549549"
     variation       622
                     /replace="a"
                     /db_xref="dbSNP:772014965"
     variation       624
                     /replace="p"
                     /db_xref="dbSNP:138812566"
     variation       624
                     /replace="r"
                     /db_xref="dbSNP:972271442"
     variation       625
                     /replace="k"
                     /db_xref="dbSNP:754396876"
     variation       626
                     /replace="d"
                     /db_xref="dbSNP:757708886"
     variation       626
                     /replace="s"
                     /db_xref="dbSNP:778975417"
     variation       626
                     /replace="y"
                     /db_xref="dbSNP:1222623072"
     variation       627
                     /replace="r"
                     /db_xref="dbSNP:200963739"
     variation       628
                     /replace="*"
                     /db_xref="dbSNP:745879536"
     variation       628
                     /replace="c"
                     /db_xref="dbSNP:758471657"
     variation       629
                     /replace="p"
                     /db_xref="dbSNP:201594771"
     variation       630
                     /replace="l"
                     /db_xref="dbSNP:142818229"
     variation       630
                     /replace="p"
                     /db_xref="dbSNP:769674897"
     Region          631..1232
                     /region_name="Peptidase M2 2"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P12821.1)"
     variation       631
                     /replace="l"
                     /db_xref="dbSNP:749271989"
     variation       631
                     /replace="p"
                     /db_xref="dbSNP:770935701"
     variation       635
                     /replace="t"
                     /db_xref="dbSNP:774004648"
     variation       637
                     /replace="l"
                     /db_xref="dbSNP:767112824"
     variation       637
                     /replace="p"
                     /db_xref="dbSNP:200255554"
     variation       637
                     /replace="t"
                     /db_xref="dbSNP:759173310"
     variation       638
                     /replace="k"
                     /db_xref="dbSNP:760201372"
     variation       639
                     /replace="s"
                     /db_xref="dbSNP:72845024"
     variation       639
                     /replace="v"
                     /db_xref="dbSNP:754090770"
     variation       640
                     /replace="r"
                     /db_xref="dbSNP:1307478617"
     variation       641
                     /replace="e"
                     /db_xref="dbSNP:1300962232"
     variation       641
                     /replace="v"
                     /db_xref="dbSNP:759386648"
     Region          643..1221
                     /region_name="Peptidase_M2"
                     /note="Angiotensin-converting enzyme; pfam01401"
                     /db_xref="CDD:279709"
     variation       643
                     /replace="a"
                     /db_xref="dbSNP:1317871269"
     variation       643
                     /replace="m"
                     /db_xref="dbSNP:767279985"
     variation       644
                     /replace="s"
                     /db_xref="dbSNP:752660066"
     variation       644
                     /replace="t"
                     /db_xref="dbSNP:760553706"
     variation       645
                     /replace="a"
                     /db_xref="dbSNP:1281544974"
     variation       645
                     /replace="d"
                     /db_xref="dbSNP:753318005"
     variation       645
                     /replace="n"
                     /db_xref="dbSNP:763603427"
     variation       647
                     /replace="t"
                     /db_xref="dbSNP:1325764936"
     variation       652
                     /replace="y"
                     /db_xref="dbSNP:1393713094"
     variation       653
                     /replace="l"
                     /db_xref="dbSNP:1248095456"
     variation       655
                     /replace="*"
                     /db_xref="dbSNP:1371611657"
     variation       655
                     /replace="d"
                     /db_xref="dbSNP:1487276305"
     variation       656
                     /replace="y"
                     /db_xref="dbSNP:756717025"
     variation       658
                     /replace="q"
                     /db_xref="dbSNP:892146398"
     variation       658
                     /replace="r"
                     /db_xref="dbSNP:1338720214"
     variation       658
                     /replace="w"
                     /db_xref="dbSNP:778684365"
     variation       659
                     /replace="t"
                     /db_xref="dbSNP:1441313370"
     variation       660
                     /replace="c"
                     /db_xref="dbSNP:147429960"
     variation       661
                     /replace="l"
                     /db_xref="dbSNP:1406304639"
     variation       662
                     /replace="g"
                     /db_xref="dbSNP:1379553980"
     variation       662
                     /replace="v"
                     /db_xref="dbSNP:373521244"
     variation       663
                     /replace="l"
                     /db_xref="dbSNP:1178170347"
     variation       664
                     /replace="*"
                     /db_xref="dbSNP:1419177611"
     variation       665
                     /replace="n"
                     /db_xref="dbSNP:758871975"
     variation       666
                     /replace="k"
                     /db_xref="dbSNP:201804955"
     variation       667
                     /replace="c"
                     /db_xref="dbSNP:1434646780"
     variation       668
                     /replace="a"
                     /db_xref="dbSNP:747542111"
     variation       669
                     /replace="g"
                     /db_xref="dbSNP:1266247312"
     variation       669
                     /replace="k"
                     /db_xref="dbSNP:769228405"
     variation       670
                     /replace="d"
                     /db_xref="dbSNP:1177823963"
     variation       671
                     /replace="s"
                     /db_xref="dbSNP:538715770"
     variation       673
                     /replace="k"
                     /db_xref="dbSNP:564928656"
     variation       675
                     /replace="h"
                     /db_xref="dbSNP:1245129210"
     variation       675
                     /replace="n"
                     /db_xref="dbSNP:773535888"
     variation       678
                     /replace="v"
                     /db_xref="dbSNP:371131106"
     variation       679
                     /replace="a"
                     /db_xref="dbSNP:771872424"
     variation       679
                     /replace="i"
                     /db_xref="dbSNP:532375661"
     variation       679
                     /replace="t"
                     /db_xref="dbSNP:775205401"
     variation       680
                     /replace="t"
                     /db_xref="dbSNP:760606594"
     variation       681
                     /replace="d"
                     /db_xref="dbSNP:764154741"
     variation       682
                     /replace="n"
                     /db_xref="dbSNP:753705010"
     variation       683
                     /replace="s"
                     /db_xref="dbSNP:148491967"
     variation       684
                     /replace="n"
                     /db_xref="dbSNP:1453772021"
     variation       684
                     /replace="r"
                     /db_xref="dbSNP:1208760916"
     variation       686
                     /replace="l"
                     /db_xref="dbSNP:1237524761"
     variation       687
                     /replace="l"
                     /db_xref="dbSNP:759228081"
     variation       689
                     /replace="k"
                     /db_xref="dbSNP:141790596"
     variation       690
                     /replace="n"
                     /db_xref="dbSNP:1334386288"
     variation       691
                     /replace="v"
                     /db_xref="dbSNP:775191459"
     variation       692
                     /replace="*"
                     /db_xref="dbSNP:1260448350"
     variation       692
                     /replace="q"
                     /db_xref="dbSNP:760990165"
     variation       694
                     /replace="a"
                     /db_xref="dbSNP:150811476"
     variation       694
                     /replace="t"
                     /db_xref="dbSNP:764410917"
     variation       695
                     /replace="s"
                     /db_xref="dbSNP:762256846"
     variation       696
                     /replace="n"
                     /db_xref="dbSNP:1187097777"
     variation       697
                     /replace="s"
                     /db_xref="dbSNP:765315607"
     variation       698
                     /replace="l"
                     /db_xref="dbSNP:780083903"
     variation       699
                     /replace="k"
                     /db_xref="dbSNP:758500055"
     variation       700
                     /replace="y"
                     /db_xref="dbSNP:780199864"
     variation       701
                     /replace="s"
                     /db_xref="dbSNP:1172339137"
     variation       703
                     /replace="h"
                     /db_xref="dbSNP:751787326"
     variation       704
                     /replace="v"
                     /db_xref="dbSNP:756018163"
     variation       706
                     /replace="r"
                     /db_xref="dbSNP:777673950"
     variation       708
                     /replace="n"
                     /db_xref="dbSNP:1303374381"
     variation       709
                     /replace="v"
                     /db_xref="dbSNP:749263426"
     variation       710
                     /replace="i"
                     /db_xref="dbSNP:770923059"
     variation       713
                     /replace="q"
                     /db_xref="dbSNP:1024570279"
     variation       714
                     /replace="k"
                     /db_xref="dbSNP:778987310"
     variation       716
                     /replace="a"
                     /db_xref="dbSNP:745422986"
     variation       717
                     /replace="m"
                     /db_xref="dbSNP:771585066"
     variation       717
                     /replace="q"
                     /db_xref="dbSNP:1219522144"
     variation       718
                     /replace="r"
                     /db_xref="dbSNP:1316503803"
     variation       719
                     /replace="q"
                     /db_xref="dbSNP:371010069"
     variation       719
                     /replace="w"
                     /db_xref="dbSNP:200649158"
     variation       720
                     /replace="i"
                     /db_xref="dbSNP:1484498158"
     variation       721
                     /replace="m"
                     /db_xref="dbSNP:1424703433"
     variation       721
                     /replace="v"
                     /db_xref="dbSNP:769028657"
     variation       722
                     /replace="n"
                     /db_xref="dbSNP:188993222"
     variation       723
                     /replace="n"
                     /db_xref="dbSNP:1488331662"
     variation       725
                     /replace="e"
                     /db_xref="dbSNP:139263584"
     variation       726
                     /replace="d"
                     /db_xref="dbSNP:909163184"
     variation       726
                     /replace="v"
                     /db_xref="dbSNP:1420953232"
     variation       727
                     /replace="l"
                     /db_xref="dbSNP:765802481"
     variation       729
                     /replace="q"
                     /db_xref="dbSNP:201527082"
     variation       729
                     /replace="r"
                     /db_xref="dbSNP:35553988"
     variation       729
                     /replace="w"
                     /db_xref="dbSNP:375232467"
     variation       730
                     /replace="e"
                     /db_xref="dbSNP:767880620"
     variation       731
                     /replace="a"
                     /db_xref="dbSNP:4331"
     variation       731
                     /replace="v"
                     /db_xref="dbSNP:1374995262"
     variation       732
                     /replace="l"
                     /db_xref="dbSNP:1300293916"
     variation       732
                     /replace="l"
                     /db_xref="dbSNP:368447908"
     variation       734
                     /replace="s"
                     /db_xref="dbSNP:199785479"
     variation       735
                     /replace="*"
                     /db_xref="dbSNP:933390771"
     variation       737
                     /replace="l"
                     /db_xref="dbSNP:1314277860"
     variation       737
                     /replace="q"
                     /db_xref="dbSNP:757100327"
     variation       738
                     /replace="v"
                     /db_xref="dbSNP:1334538300"
     variation       741
                     /replace="k"
                     /db_xref="dbSNP:779433192"
     variation       742
                     /replace="k"
                     /db_xref="dbSNP:1460237403"
     variation       743
                     /replace="m"
                     /db_xref="dbSNP:1401450584"
     variation       744
                     /replace="c"
                     /db_xref="dbSNP:745767649"
     variation       745
                     /replace="l"
                     /db_xref="dbSNP:1240703640"
     variation       745
                     /replace="l"
                     /db_xref="dbSNP:945335086"
     variation       746
                     /replace="d"
                     /db_xref="dbSNP:1042309696"
     variation       748
                     /replace="g"
                     /db_xref="dbSNP:1362206431"
     variation       748
                     /replace="k"
                     /db_xref="dbSNP:921762904"
     variation       749
                     /replace="t"
                     /db_xref="dbSNP:746590318"
     variation       750
                     /replace="t"
                     /db_xref="dbSNP:374690585"
     variation       752
                     /replace="s"
                     /db_xref="dbSNP:780873477"
     variation       753
                     /replace="m"
                     /db_xref="dbSNP:140129129"
     variation       754
                     /replace="a"
                     /db_xref="dbSNP:747769267"
     variation       754
                     /replace="p"
                     /db_xref="dbSNP:1202344569"
     variation       754
                     /replace="v"
                     /db_xref="dbSNP:1319509042"
     variation       755
                     /replace="i"
                     /db_xref="dbSNP:200503880"
     variation       756
                     /replace="a"
                     /db_xref="dbSNP:377567489"
     variation       756
                     /replace="l"
                     /db_xref="dbSNP:773578992"
     variation       756
                     /replace="r"
                     /db_xref="dbSNP:772172179"
     variation       756
                     /replace="v"
                     /db_xref="dbSNP:1258404523"
     variation       757
                     /replace="y"
                     /db_xref="dbSNP:1232177858"
     variation       759
                     /replace="p"
                     /db_xref="dbSNP:199715246"
     variation       759
                     /replace="q"
                     /db_xref="dbSNP:143843660"
     variation       759
                     /replace="s"
                     /db_xref="dbSNP:1180603936"
     variation       763
                     /replace="y"
                     /db_xref="dbSNP:370481039"
     variation       764
                     /replace="q"
                     /db_xref="dbSNP:145819052"
     variation       766
                     /replace="l"
                     /db_xref="dbSNP:373339041"
     variation       767
                     /replace="g"
                     /db_xref="dbSNP:1421152152"
     variation       767
                     /replace="k"
                     /db_xref="dbSNP:148995315"
     variation       769
                     /replace="d"
                     /db_xref="dbSNP:907257051"
     variation       769
                     /replace="g"
                     /db_xref="dbSNP:559834728"
     variation       770
                     /replace="p"
                     /db_xref="dbSNP:886053223"
     variation       770
                     /replace="v"
                     /db_xref="dbSNP:374146846"
     variation       771
                     /replace="m"
                     /db_xref="dbSNP:780755664"
     variation       771
                     /replace="t"
                     /db_xref="dbSNP:747443207"
     variation       772
                     /replace="n"
                     /db_xref="dbSNP:1169638069"
     variation       773
                     /replace="m"
                     /db_xref="dbSNP:143830698"
     variation       774
                     /replace="v"
                     /db_xref="dbSNP:559585445"
     variation       775
                     /replace="v"
                     /db_xref="dbSNP:1357262996"
     variation       776
                     /replace="a"
                     /db_xref="dbSNP:199869667"
     variation       776
                     /replace="m"
                     /db_xref="dbSNP:769940023"
     variation       776
                     /replace="t"
                     /db_xref="dbSNP:4343"
     variation       778
                     /replace="q"
                     /db_xref="dbSNP:771819046"
     variation       778
                     /replace="r"
                     /db_xref="dbSNP:745724462"
     variation       780
                     /replace="y"
                     /db_xref="dbSNP:775525330"
     variation       782
                     /replace="e"
                     /db_xref="dbSNP:760477392"
     variation       783
                     /replace="l"
                     /db_xref="dbSNP:1368706438"
     variation       784
                     /replace="s"
                     /db_xref="dbSNP:1162307952"
     variation       784
                     /replace="y"
                     /db_xref="dbSNP:1476011360"
     variation       785
                     /replace="g"
                     /db_xref="dbSNP:763670346"
     variation       787
                     /replace="*"
                     /db_xref="dbSNP:775934699"
     variation       788
                     /replace="e"
                     /db_xref="dbSNP:565463716"
     variation       788
                     /replace="k"
                     /db_xref="dbSNP:761401927"
     variation       788
                     /replace="r"
                     /db_xref="dbSNP:1482032796"
     variation       789
                     /replace="d"
                     /db_xref="dbSNP:953051570"
     variation       789
                     /replace="g"
                     /db_xref="dbSNP:758874020"
     variation       791
                     /replace="*"
                     /db_xref="dbSNP:397514689"
     variation       791
                     /replace="q"
                     /db_xref="dbSNP:755385604"
     variation       792
                     /replace="d"
                     /db_xref="dbSNP:781340394"
     variation       792
                     /replace="h"
                     /db_xref="dbSNP:1291650441"
     variation       793
                     /replace="t"
                     /db_xref="dbSNP:748246753"
     variation       794
                     /replace="a"
                     /db_xref="dbSNP:61738817"
     variation       794
                     /replace="t"
                     /db_xref="dbSNP:756178155"
     variation       794
                     /replace="v"
                     /db_xref="dbSNP:373970727"
     variation       795
                     /replace="g"
                     /db_xref="dbSNP:1256296259"
     variation       797
                     /replace="t"
                     /db_xref="dbSNP:1486364002"
     variation       797
                     /replace="v"
                     /db_xref="dbSNP:1455404812"
     variation       798
                     /replace="v"
                     /db_xref="dbSNP:117647476"
     variation       799
                     /replace="-"
                     /db_xref="dbSNP:756402944"
     variation       800
                     /replace="q"
                     /db_xref="dbSNP:567706604"
     variation       801
                     /replace="f"
                     /db_xref="dbSNP:1256288128"
     variation       803
                     /replace="l"
                     /db_xref="dbSNP:367822781"
     variation       803
                     /replace="p"
                     /db_xref="dbSNP:138771270"
     variation       805
                     /replace="y"
                     /db_xref="dbSNP:761458810"
     variation       806
                     /replace="m"
                     /db_xref="dbSNP:769397961"
     variation       807
                     /replace="k"
                     /db_xref="dbSNP:924250238"
     variation       808
                     /replace="f"
                     /db_xref="dbSNP:773031583"
     variation       809
                     /replace="v"
                     /db_xref="dbSNP:762647568"
     variation       810
                     /replace="n"
                     /db_xref="dbSNP:766782146"
     variation       810
                     /replace="s"
                     /db_xref="dbSNP:1206246426"
     variation       811
                     /replace="r"
                     /db_xref="dbSNP:1255043434"
     variation       812
                     /replace="v"
                     /db_xref="dbSNP:751806358"
     variation       814
                     /replace="q"
                     /db_xref="dbSNP:375979946"
     variation       814
                     /replace="r"
                     /db_xref="dbSNP:753185179"
     variation       814
                     /replace="w"
                     /db_xref="dbSNP:142799747"
     variation       815
                     /replace="f"
                     /db_xref="dbSNP:935705219"
     variation       815
                     /replace="l"
                     /db_xref="dbSNP:201741777"
     variation       816
                     /replace="s"
                     /db_xref="dbSNP:777776998"
     variation       817
                     /replace="g"
                     /db_xref="dbSNP:757345880"
     variation       818
                     /replace="c"
                     /db_xref="dbSNP:369245002"
     variation       818
                     /replace="y"
                     /db_xref="dbSNP:146972400"
     variation       820
                     /replace="d"
                     /db_xref="dbSNP:138035588"
     variation       820
                     /replace="m"
                     /db_xref="dbSNP:757544710"
     variation       820
                     /replace="n"
                     /db_xref="dbSNP:1018632632"
     variation       821
                     /replace="a"
                     /db_xref="dbSNP:748110361"
     variation       821
                     /replace="v"
                     /db_xref="dbSNP:781086412"
     variation       822
                     /replace="e"
                     /db_xref="dbSNP:1340223445"
     variation       822
                     /replace="g"
                     /db_xref="dbSNP:758008802"
     variation       823
                     /replace="n"
                     /db_xref="dbSNP:995556379"
     variation       823
                     /replace="v"
                     /db_xref="dbSNP:777851729"
     variation       824
                     /replace="l"
                     /db_xref="dbSNP:748868465"
     variation       824
                     /replace="s"
                     /db_xref="dbSNP:149528336"
     variation       826
                     /replace="s"
                     /db_xref="dbSNP:1441728993"
     variation       827
                     /replace="c"
                     /db_xref="dbSNP:200757344"
     variation       827
                     /replace="s"
                     /db_xref="dbSNP:373925900"
     variation       828
                     /replace="t"
                     /db_xref="dbSNP:13306091"
     variation       828
                     /replace="v"
                     /db_xref="dbSNP:890006891"
     variation       829
                     /replace="y"
                     /db_xref="dbSNP:35580653"
     variation       830
                     /replace="k"
                     /db_xref="dbSNP:267604983"
     variation       831
                     /replace="i"
                     /db_xref="dbSNP:777098855"
     variation       832
                     /replace="l"
                     /db_xref="dbSNP:761838241"
     variation       834
                     /replace="l"
                     /db_xref="dbSNP:765320587"
     variation       835
                     /replace="e"
                     /db_xref="dbSNP:1368029138"
     variation       836
                     /replace="*"
                     /db_xref="dbSNP:1405858837"
     variation       839
                     /replace="qdle"
                     /db_xref="dbSNP:778824663"
     variation       840
                     /replace="l"
                     /db_xref="dbSNP:767425642"
     variation       840
                     /replace="r"
                     /db_xref="dbSNP:1378906822"
     variation       840
                     /replace="r"
                     /db_xref="dbSNP:3730036"
     variation       842
                     /replace="f"
                     /db_xref="dbSNP:777909386"
     variation       842
                     /replace="s"
                     /db_xref="dbSNP:537201274"
     variation       842
                     /replace="v"
                     /db_xref="dbSNP:200156271"
     variation       843
                     /replace="p"
                     /db_xref="dbSNP:1314869920"
     variation       843
                     /replace="r"
                     /db_xref="dbSNP:956900465"
     variation       844
                     /replace="e"
                     /db_xref="dbSNP:1164834510"
     variation       845
                     /replace="l"
                     /db_xref="dbSNP:749222932"
     variation       846
                     /replace="q"
                     /db_xref="dbSNP:990108624"
     variation       847
                     /replace="p"
                     /db_xref="dbSNP:1295993343"
     variation       848
                     /replace="l"
                     /db_xref="dbSNP:377651738"
     variation       848
                     /replace="v"
                     /db_xref="dbSNP:1263864253"
     variation       849
                     /replace="y"
                     /db_xref="dbSNP:1415088003"
     variation       850
                     /replace="l"
                     /db_xref="dbSNP:4975"
     variation       852
                     /replace="l"
                     /db_xref="dbSNP:778424815"
     variation       853
                     /replace="h"
                     /db_xref="dbSNP:771821963"
     variation       853
                     /replace="y"
                     /db_xref="dbSNP:377172559"
     variation       854
                     /replace="a"
                     /db_xref="dbSNP:1350354651"
     variation       854
                     /replace="d"
                     /db_xref="dbSNP:1258657289"
     variation       855
                     /replace="c"
                     /db_xref="dbSNP:1290778035"
     variation       855
                     /replace="y"
                     /db_xref="dbSNP:775109143"
     variation       856
                     /replace="m"
                     /db_xref="dbSNP:369111551"
     variation       857
                     /replace="g"
                     /db_xref="dbSNP:989791368"
     variation       857
                     /replace="l"
                     /db_xref="dbSNP:146089353"
     variation       858
                     /replace="q"
                     /db_xref="dbSNP:765246562"
     variation       858
                     /replace="w"
                     /db_xref="dbSNP:762333619"
     variation       859
                     /replace="t"
                     /db_xref="dbSNP:1474446784"
     variation       860
                     /replace="p"
                     /db_xref="dbSNP:773277069"
     variation       860
                     /replace="v"
                     /db_xref="dbSNP:1164595381"
     variation       861
                     /replace="h"
                     /db_xref="dbSNP:143699430"
     variation       861
                     /replace="l"
                     /db_xref="dbSNP:886053224"
     variation       861
                     /replace="y"
                     /db_xref="dbSNP:140056206"
     variation       862
                     /replace="c"
                     /db_xref="dbSNP:751363862"
     variation       862
                     /replace="h"
                     /db_xref="dbSNP:756018518"
     variation       864
                     /replace="y"
                     /db_xref="dbSNP:151293350"
     variation       865
                     /replace="r"
                     /db_xref="dbSNP:939884644"
     variation       866
                     /replace="s"
                     /db_xref="dbSNP:1037068942"
     variation       867
                     /replace="*"
                     /db_xref="dbSNP:1413766379"
     variation       868
                     /replace="h"
                     /db_xref="dbSNP:753727679"
     variation       869
                     /replace="v"
                     /db_xref="dbSNP:757164151"
     variation       870
                     /replace="n"
                     /db_xref="dbSNP:778706118"
     variation       871
                     /replace="l"
                     /db_xref="dbSNP:370952587"
     variation       871
                     /replace="l"
                     /db_xref="dbSNP:376968481"
     variation       871
                     /replace="q"
                     /db_xref="dbSNP:1272138201"
     variation       874
                     /replace="p"
                     /db_xref="dbSNP:139366898"
     variation       876
                     /replace="p"
                     /db_xref="dbSNP:1276783700"
     variation       876
                     /replace="s"
                     /db_xref="dbSNP:757874491"
     variation       877
                     /replace="g"
                     /db_xref="dbSNP:931392712"
     variation       878
                     /replace="n"
                     /db_xref="dbSNP:781252796"
     variation       878
                     /replace="q"
                     /db_xref="dbSNP:200196657"
     variation       879
                     /replace="l"
                     /db_xref="dbSNP:1049715807"
     variation       879
                     /replace="q"
                     /db_xref="dbSNP:886053225"
     variation       881
                     /replace="e"
                     /db_xref="dbSNP:1232536510"
     variation       881
                     /replace="g"
                     /db_xref="dbSNP:558624181"
     variation       882
                     /replace="s"
                     /db_xref="dbSNP:1466430617"
     variation       882
                     /replace="s"
                     /db_xref="dbSNP:771162255"
     variation       883
                     /replace="i"
                     /db_xref="dbSNP:759679121"
     variation       883
                     /replace="t"
                     /db_xref="dbSNP:1267969615"
     variation       883
                     /replace="v"
                     /db_xref="dbSNP:774518339"
     variation       884
                     /replace="r"
                     /db_xref="dbSNP:568842388"
     variation       885
                     /replace="a"
                     /db_xref="dbSNP:775546287"
     variation       885
                     /replace="p"
                     /db_xref="dbSNP:1173972262"
     variation       885
                     /replace="v"
                     /db_xref="dbSNP:1251602237"
     variation       887
                     /replace="a"
                     /db_xref="dbSNP:1181835738"
     variation       887
                     /replace="n"
                     /db_xref="dbSNP:761719023"
     variation       888
                     /replace="c"
                     /db_xref="dbSNP:1157631466"
     variation       888
                     /replace="s"
                     /db_xref="dbSNP:1468320560"
     variation       891
                     /replace="i"
                     /db_xref="dbSNP:764892659"
     variation       892
                     /replace="*"
                     /db_xref="dbSNP:762809850"
     variation       892
                     /replace="c"
                     /db_xref="dbSNP:750406199"
     variation       894
                     /replace="m"
                     /db_xref="dbSNP:150057535"
     variation       895
                     /replace="l"
                     /db_xref="dbSNP:1393589215"
     variation       896
                     /replace="m"
                     /db_xref="dbSNP:145422285"
     variation       896
                     /replace="v"
                     /db_xref="dbSNP:751127924"
     variation       898
                     /replace="f"
                     /db_xref="dbSNP:368583571"
     variation       901
                     /replace="s"
                     /db_xref="dbSNP:752266791"
     variation       902
                     /replace="p"
                     /db_xref="dbSNP:756520690"
     variation       903
                     /replace="s"
                     /db_xref="dbSNP:537418583"
     variation       903
                     /replace="w"
                     /db_xref="dbSNP:558504919"
     variation       904
                     /replace="t"
                     /db_xref="dbSNP:779560946"
     variation       905
                     /replace="d"
                     /db_xref="dbSNP:1196859745"
     variation       905
                     /replace="v"
                     /db_xref="dbSNP:745987517"
     variation       906
                     /replace="a"
                     /db_xref="dbSNP:1274588146"
     variation       906
                     /replace="i"
                     /db_xref="dbSNP:772024137"
     variation       906
                     /replace="t"
                     /db_xref="dbSNP:775805256"
     variation       908
                     /replace="k"
                     /db_xref="dbSNP:747159428"
     variation       909
                     /replace="s"
                     /db_xref="dbSNP:1290624816"
     variation       911
                     /replace="l"
                     /db_xref="dbSNP:769636081"
     variation       912
                     /replace="r"
                     /db_xref="dbSNP:1329922107"
     variation       913
                     /replace="e"
                     /db_xref="dbSNP:372614913"
     variation       913
                     /replace="r"
                     /db_xref="dbSNP:1026599078"
     variation       914
                     /replace="d"
                     /db_xref="dbSNP:1362563545"
     variation       915
                     /replace="s"
                     /db_xref="dbSNP:1271898535"
     variation       916
                     /replace="a"
                     /db_xref="dbSNP:755053417"
     variation       916
                     /replace="m"
                     /db_xref="dbSNP:3730043"
     variation       916
                     /replace="t"
                     /db_xref="dbSNP:1174230478"
     variation       917
                     /replace="a"
                     /db_xref="dbSNP:748317639"
     variation       917
                     /replace="r"
                     /db_xref="dbSNP:770741758"
     variation       918
                     /replace="r"
                     /db_xref="dbSNP:145809210"
     variation       920
                     /replace="t"
                     /db_xref="dbSNP:745827618"
     variation       922
                     /replace="e"
                     /db_xref="dbSNP:551723440"
     variation       928
                     /replace="f"
                     /db_xref="dbSNP:1327095929"
     variation       929
                     /replace="a"
                     /db_xref="dbSNP:1005152265"
     variation       929
                     /replace="t"
                     /db_xref="dbSNP:4348"
     variation       930
                     /replace="f"
                     /db_xref="dbSNP:1231385013"
     variation       931
                     /replace="l"
                     /db_xref="dbSNP:141180606"
     variation       931
                     /replace="p"
                     /db_xref="dbSNP:1317192622"
     variation       932
                     /replace="a"
                     /db_xref="dbSNP:768235439"
     variation       932
                     /replace="g"
                     /db_xref="dbSNP:776455909"
     variation       932
                     /replace="r"
                     /db_xref="dbSNP:1335323894"
     variation       933
                     /replace="l"
                     /db_xref="dbSNP:200269676"
     variation       934
                     /replace="l"
                     /db_xref="dbSNP:1214262041"
     variation       935
                     /replace="l"
                     /db_xref="dbSNP:537884559"
     variation       935
                     /replace="p"
                     /db_xref="dbSNP:370847170"
     variation       935
                     /replace="s"
                     /db_xref="dbSNP:199555061"
     variation       936
                     /replace="m"
                     /db_xref="dbSNP:752081336"
     variation       939
                     /replace="q"
                     /db_xref="dbSNP:755034079"
     variation       940
                     /replace="l"
                     /db_xref="dbSNP:975148117"
     variation       941
                     /replace="c"
                     /db_xref="dbSNP:1202055050"
     variation       941
                     /replace="r"
                     /db_xref="dbSNP:375020796"
     variation       942
                     /replace="h"
                     /db_xref="dbSNP:1290388486"
     variation       942
                     /replace="k"
                     /db_xref="dbSNP:201517271"
     variation       943
                     /replace="n"
                     /db_xref="dbSNP:1456982290"
     variation       943
                     /replace="r"
                     /db_xref="dbSNP:777955033"
     variation       944
                     /replace="q"
                     /db_xref="dbSNP:1221050110"
     variation       944
                     /replace="s"
                     /db_xref="dbSNP:866899407"
     variation       946
                     /replace="v"
                     /db_xref="dbSNP:1397259349"
     variation       947
                     /replace="k"
                     /db_xref="dbSNP:201076681"
     variation       948
                     /replace="-"
                     /db_xref="dbSNP:1292471704"
     variation       948
                     /replace="k"
                     /db_xref="dbSNP:771881312"
     variation       949
                     /replace="s"
                     /db_xref="dbSNP:779881202"
     variation       950
                     /replace="t"
                     /db_xref="dbSNP:746927014"
     variation       951
                     /replace="d"
                     /db_xref="dbSNP:752529945"
     variation       951
                     /replace="n"
                     /db_xref="dbSNP:776223808"
     variation       952
                     /replace="r"
                     /db_xref="dbSNP:987787902"
     variation       953
                     /replace="q"
                     /db_xref="dbSNP:143507892"
     variation       953
                     /replace="r"
                     /db_xref="dbSNP:922132884"
     variation       953
                     /replace="w"
                     /db_xref="dbSNP:772888815"
     variation       954
                     /replace="g"
                     /db_xref="dbSNP:780072379"
     variation       955
                     /replace="v"
                     /db_xref="dbSNP:766716582"
     variation       956
                     /replace="v"
                     /db_xref="dbSNP:774748647"
     variation       957
                     /replace="r"
                     /db_xref="dbSNP:759966983"
     variation       957
                     /replace="s"
                     /db_xref="dbSNP:767594429"
     Site            order(958..960,988..989,992,1016,1062,1116..1118,1123,
                     1125,1128)
                     /site_type="active"
                     /db_xref="CDD:188999"
     variation       958
                     /replace="h"
                     /db_xref="dbSNP:148024347"
     variation       959
                     /replace="a"
                     /db_xref="dbSNP:367799203"
     variation       959
                     /replace="d"
                     /db_xref="dbSNP:764275894"
     variation       959
                     /replace="t"
                     /db_xref="dbSNP:756159839"
     variation       960
                     /replace="l"
                     /db_xref="dbSNP:1420430019"
     variation       960
                     /replace="s"
                     /db_xref="dbSNP:758161582"
     variation       961
                     /replace="p"
                     /db_xref="dbSNP:779833433"
     variation       963
                     /replace="n"
                     /db_xref="dbSNP:1354629347"
     variation       966
                     /replace="d"
                     /db_xref="dbSNP:746934582"
     variation       966
                     /replace="n"
                     /db_xref="dbSNP:532039424"
     variation       967
                     /replace="g"
                     /db_xref="dbSNP:781271191"
     variation       967
                     /replace="s"
                     /db_xref="dbSNP:937878555"
     variation       969
                     /replace="y"
                     /db_xref="dbSNP:913463914"
     variation       970
                     /replace="f"
                     /db_xref="dbSNP:747700760"
     variation       971
                     /replace="l"
                     /db_xref="dbSNP:554004241"
     variation       971
                     /replace="w"
                     /db_xref="dbSNP:769406157"
     variation       974
                     /replace="r"
                     /db_xref="dbSNP:375442845"
     variation       975
                     /replace="c"
                     /db_xref="dbSNP:761107328"
     variation       975
                     /replace="g"
                     /db_xref="dbSNP:1318768216"
     variation       975
                     /replace="y"
                     /db_xref="dbSNP:1346738730"
     variation       977
                     /replace="i"
                     /db_xref="dbSNP:1439040577"
     variation       977
                     /replace="t"
                     /db_xref="dbSNP:768632989"
     variation       978
                     /replace="m"
                     /db_xref="dbSNP:141750591"
     variation       981
                     /replace="d"
                     /db_xref="dbSNP:868230881"
     variation       983
                     /replace="l"
                     /db_xref="dbSNP:1041542720"
     variation       983
                     /replace="l"
                     /db_xref="dbSNP:761795254"
     variation       983
                     /replace="p"
                     /db_xref="dbSNP:931669958"
     variation       984
                     /replace="v"
                     /db_xref="dbSNP:3730044"
     variation       985
                     /replace="v"
                     /db_xref="dbSNP:1343201751"
     variation       986
                     /replace="p"
                     /db_xref="dbSNP:1218838386"
     variation       987
                     /replace="h"
                     /db_xref="dbSNP:369689246"
     variation       987
                     /replace="y"
                     /db_xref="dbSNP:1285477249"
     Site            order(988,992,1016)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188999"
     variation       988
                     /replace="h"
                     /db_xref="dbSNP:767378617"
     variation       988
                     /replace="r"
                     /db_xref="dbSNP:1315238107"
     variation       989
                     /replace="k"
                     /db_xref="dbSNP:752685131"
     variation       990
                     /replace="i"
                     /db_xref="dbSNP:1227030637"
     variation       990
                     /replace="r"
                     /db_xref="dbSNP:1468555557"
     variation       991
                     /replace="s"
                     /db_xref="dbSNP:756019276"
     variation       992
                     /replace="d"
                     /db_xref="dbSNP:1244440863"
     variation       992
                     /replace="h"
                     /db_xref="dbSNP:373198685"
     variation       992
                     /replace="r"
                     /db_xref="dbSNP:771384705"
     variation       993
                     /replace="i"
                     /db_xref="dbSNP:75067113"
     variation       993
                     /replace="v"
                     /db_xref="dbSNP:753450698"
     variation       995
                     /replace="h"
                     /db_xref="dbSNP:778562737"
     variation       997
                     /replace="i"
                     /db_xref="dbSNP:1395070641"
     variation       997
                     /replace="v"
                     /db_xref="dbSNP:745486055"
     variation       998
                     /replace="k"
                     /db_xref="dbSNP:772433710"
     variation       999
                     /replace="c"
                     /db_xref="dbSNP:1325658187"
     variation       999
                     /replace="y"
                     /db_xref="dbSNP:146046369"
     variation       1002
                     /replace="l"
                     /db_xref="dbSNP:1436102382"
     variation       1003
                     /replace="-"
                     /db_xref="dbSNP:746977732"
     variation       1003
                     /replace="l"
                     /db_xref="dbSNP:377280373"
     variation       1007
                     /replace="k"
                     /db_xref="dbSNP:747362596"
     variation       1009
                     /replace="v"
                     /db_xref="dbSNP:769272334"
     variation       1010
                     /replace="a"
                     /db_xref="dbSNP:1041524189"
     variation       1012
                     /replace="p"
                     /db_xref="dbSNP:147806836"
     variation       1013
                     /replace="a"
                     /db_xref="dbSNP:540734174"
     variation       1013
                     /replace="s"
                     /db_xref="dbSNP:571848794"
     variation       1014
                     /replace="f"
                     /db_xref="dbSNP:1350437085"
     variation       1015
                     /replace="q"
                     /db_xref="dbSNP:144751624"
     variation       1015
                     /replace="r"
                     /db_xref="dbSNP:773600140"
     variation       1016
                     /replace="e"
                     /db_xref="dbSNP:1253480175"
     variation       1017
                     /replace="t"
                     /db_xref="dbSNP:1471502216"
     variation       1018
                     /replace="t"
                     /db_xref="dbSNP:4976"
     variation       1019
                     /replace="g"
                     /db_xref="dbSNP:752593254"
     variation       1019
                     /replace="r"
                     /db_xref="dbSNP:1418273122"
     variation       1020
                     /replace="d"
                     /db_xref="dbSNP:373427509"
     variation       1020
                     /replace="g"
                     /db_xref="dbSNP:1200211350"
     variation       1021
                     /replace="m"
                     /db_xref="dbSNP:764129854"
     variation       1023
                     /replace="t"
                     /db_xref="dbSNP:201529811"
     variation       1024
                     /replace="f"
                     /db_xref="dbSNP:753672462"
     variation       1025
                     /replace="a"
                     /db_xref="dbSNP:1489092015"
     variation       1026
                     /replace="a"
                     /db_xref="dbSNP:1372691116"
     variation       1026
                     /replace="m"
                     /db_xref="dbSNP:377550847"
     variation       1027
                     /replace="s"
                     /db_xref="dbSNP:756826166"
     variation       1027
                     /replace="y"
                     /db_xref="dbSNP:1170915014"
     variation       1028
                     /replace="m"
                     /db_xref="dbSNP:778331848"
     variation       1028
                     /replace="t"
                     /db_xref="dbSNP:750092571"
     variation       1029
                     /replace="s"
                     /db_xref="dbSNP:758105347"
     variation       1030
                     /replace="n"
                     /db_xref="dbSNP:374679629"
     variation       1032
                     /replace="l"
                     /db_xref="dbSNP:1355072990"
     variation       1033
                     /replace="h"
                     /db_xref="dbSNP:768882213"
     variation       1033
                     /replace="p"
                     /db_xref="dbSNP:747442787"
     variation       1035
                     /replace="l"
                     /db_xref="dbSNP:781732987"
     variation       1036
                     /replace="k"
                     /db_xref="dbSNP:142947404"
     variation       1037
                     /replace="l"
                     /db_xref="dbSNP:769998393"
     variation       1037
                     /replace="p"
                     /db_xref="dbSNP:1258035065"
     variation       1038
                     /replace="l"
                     /db_xref="dbSNP:773367295"
     variation       1039
                     /replace="n"
                     /db_xref="dbSNP:1368193999"
     variation       1040
                     /replace="t"
                     /db_xref="dbSNP:749362077"
     variation       1041
                     /replace="-"
                     /db_xref="dbSNP:768525377"
     variation       1041
                     /replace="e"
                     /db_xref="dbSNP:771342124"
     variation       1044
                     /replace="s"
                     /db_xref="dbSNP:150690061"
     variation       1045
                     /replace="d"
                     /db_xref="dbSNP:200011052"
     variation       1045
                     /replace="h"
                     /db_xref="dbSNP:140980792"
     variation       1046
                     /replace="k"
                     /db_xref="dbSNP:761601299"
     variation       1047
                     /replace="h"
                     /db_xref="dbSNP:762473590"
     variation       1048
                     /replace="g"
                     /db_xref="dbSNP:1313627969"
     variation       1049
                     /replace="v"
                     /db_xref="dbSNP:765835019"
     variation       1050
                     /replace="d"
                     /db_xref="dbSNP:751226904"
     variation       1050
                     /replace="s"
                     /db_xref="dbSNP:935304784"
     variation       1051
                     /replace="v"
                     /db_xref="dbSNP:4977"
     variation       1052
                     /replace="p"
                     /db_xref="dbSNP:1351048530"
     variation       1052
                     /replace="v"
                     /db_xref="dbSNP:989584821"
     variation       1054
                     /replace="k"
                     /db_xref="dbSNP:1210514649"
     variation       1055
                     /replace="i"
                     /db_xref="dbSNP:767184799"
     variation       1055
                     /replace="l"
                     /db_xref="dbSNP:144926742"
     variation       1056
                     /replace="a"
                     /db_xref="dbSNP:1007334111"
     variation       1056
                     /replace="t"
                     /db_xref="dbSNP:569898686"
     variation       1057
                     /replace="l"
                     /db_xref="dbSNP:756512070"
     variation       1058
                     /replace="d"
                     /db_xref="dbSNP:778470338"
     variation       1058
                     /replace="g"
                     /db_xref="dbSNP:1458584759"
     variation       1058
                     /replace="n"
                     /db_xref="dbSNP:1197014458"
     variation       1060
                     /replace="i"
                     /db_xref="dbSNP:754344947"
     variation       1060
                     /replace="v"
                     /db_xref="dbSNP:1458035301"
     variation       1061
                     /replace="s"
                     /db_xref="dbSNP:773695336"
     variation       1062
                     /replace="l"
                     /db_xref="dbSNP:778802598"
     variation       1063
                     /replace="i"
                     /db_xref="dbSNP:745951639"
     variation       1064
                     /replace="l"
                     /db_xref="dbSNP:1384728709"
     variation       1064
                     /replace="s"
                     /db_xref="dbSNP:747724861"
     variation       1065
                     /replace="f"
                     /db_xref="dbSNP:1300081096"
     variation       1067
                     /replace="c"
                     /db_xref="dbSNP:1382876528"
     variation       1067
                     /replace="h"
                     /db_xref="dbSNP:1342469069"
     variation       1068
                     /replace="l"
                     /db_xref="dbSNP:189373608"
     variation       1069
                     /replace="a"
                     /db_xref="dbSNP:1322398043"
     variation       1069
                     /replace="i"
                     /db_xref="dbSNP:147763588"
     variation       1069
                     /replace="v"
                     /db_xref="dbSNP:371996217"
     variation       1070
                     /replace="n"
                     /db_xref="dbSNP:571910640"
     variation       1071
                     /replace="k"
                     /db_xref="dbSNP:769531227"
     variation       1072
                     /replace="*"
                     /db_xref="dbSNP:773163752"
     variation       1073
                     /replace="c"
                     /db_xref="dbSNP:762807750"
     variation       1073
                     /replace="h"
                     /db_xref="dbSNP:141139841"
     variation       1074
                     /replace="*"
                     /db_xref="dbSNP:1266895232"
     variation       1075
                     /replace="r"
                     /db_xref="dbSNP:1164187187"
     variation       1076
                     /replace="l"
                     /db_xref="dbSNP:534480370"
     variation       1078
                     /replace="g"
                     /db_xref="dbSNP:375039288"
     variation       1079
                     /replace="e"
                     /db_xref="dbSNP:752369560"
     variation       1080
                     /replace="c"
                     /db_xref="dbSNP:1472584106"
     variation       1080
                     /replace="n"
                     /db_xref="dbSNP:1166034708"
     variation       1081
                     /replace="v"
                     /db_xref="dbSNP:761139845"
     variation       1084
                     /replace="k"
                     /db_xref="dbSNP:1455896148"
     variation       1086
                     /replace="y"
                     /db_xref="dbSNP:1292602898"
     variation       1088
                     /replace="h"
                     /db_xref="dbSNP:764489358"
     variation       1091
                     /replace="*"
                     /db_xref="dbSNP:1411245193"
     variation       1092
                     /replace="s"
                     /db_xref="dbSNP:768017942"
     variation       1094
                     /replace="g"
                     /db_xref="dbSNP:754412363"
     variation       1099
                     /replace="d"
                     /db_xref="dbSNP:775421383"
     variation       1100
                     /replace="l"
                     /db_xref="dbSNP:757051176"
     variation       1101
                     /replace="c"
                     /db_xref="dbSNP:1040513482"
     variation       1102
                     /replace="t"
                     /db_xref="dbSNP:145349565"
     variation       1103
                     /replace="p"
                     /db_xref="dbSNP:771498675"
     variation       1103
                     /replace="t"
                     /db_xref="dbSNP:745776314"
     variation       1104
                     /replace="a"
                     /db_xref="dbSNP:1458829834"
     variation       1104
                     /replace="s"
                     /db_xref="dbSNP:1447215842"
     variation       1105
                     /replace="p"
                     /db_xref="dbSNP:1339023151"
     variation       1107
                     /replace="t"
                     /db_xref="dbSNP:144974035"
     variation       1108
                     /replace="q"
                     /db_xref="dbSNP:746517733"
     variation       1109
                     /replace="g"
                     /db_xref="dbSNP:776400866"
     variation       1109
                     /replace="v"
                     /db_xref="dbSNP:768468260"
     variation       1110
                     /replace="d"
                     /db_xref="dbSNP:1269279770"
     variation       1111
                     /replace="l"
                     /db_xref="dbSNP:1465879181"
     variation       1112
                     /replace="d"
                     /db_xref="dbSNP:762107963"
     variation       1115
                     /replace="a"
                     /db_xref="dbSNP:773598878"
     variation       1115
                     /replace="d"
                     /db_xref="dbSNP:565263717"
     variation       1118
                     /replace="h"
                     /db_xref="dbSNP:192029734"
     variation       1118
                     /replace="y"
                     /db_xref="dbSNP:1192509168"
     variation       1121
                     /replace="s"
                     /db_xref="dbSNP:200201337"
     variation       1122
                     /replace="s"
                     /db_xref="dbSNP:149084065"
     variation       1123
                     /replace="m"
                     /db_xref="dbSNP:373319603"
     variation       1124
                     /replace="t"
                     /db_xref="dbSNP:1455545095"
     variation       1125
                     /replace="y"
                     /db_xref="dbSNP:1396260507"
     variation       1126
                     /replace="l"
                     /db_xref="dbSNP:567659245"
     variation       1127
                     /replace="s"
                     /db_xref="dbSNP:1229959665"
     variation       1128
                     /replace="c"
                     /db_xref="dbSNP:1481913226"
     variation       1128
                     /replace="y"
                     /db_xref="dbSNP:1181039131"
     variation       1129
                     /replace="f"
                     /db_xref="dbSNP:4362"
     variation       1130
                     /replace="-"
                     /db_xref="dbSNP:772585024"
     variation       1130
                     /replace="i"
                     /db_xref="dbSNP:575830312"
     variation       1130
                     /replace="m"
                     /db_xref="dbSNP:762468887"
     variation       1130
                     /replace="q"
                     /db_xref="dbSNP:770429365"
     variation       1130
                     /replace="v"
                     /db_xref="dbSNP:1173793027"
     variation       1131
                     /replace="i"
                     /db_xref="dbSNP:777258874"
     variation       1131
                     /replace="p"
                     /db_xref="dbSNP:775933853"
     variation       1132
                     /replace="l"
                     /db_xref="dbSNP:1308790992"
     variation       1133
                     /replace="i"
                     /db_xref="dbSNP:1431115842"
     variation       1135
                     /replace="k"
                     /db_xref="dbSNP:749711522"
     variation       1135
                     /replace="q"
                     /db_xref="dbSNP:1328570712"
     variation       1135
                     /replace="r"
                     /db_xref="dbSNP:771232505"
     variation       1137
                     /replace="*"
                     /db_xref="dbSNP:1341633213"
     variation       1138
                     /replace="f"
                     /db_xref="dbSNP:774866263"
     variation       1139
                     /replace="h"
                     /db_xref="dbSNP:112577612"
     variation       1139
                     /replace="y"
                     /db_xref="dbSNP:1281978641"
     variation       1140
                     /replace="e"
                     /db_xref="dbSNP:1276287470"
     variation       1140
                     /replace="k"
                     /db_xref="dbSNP:1228691156"
     variation       1143
                     /replace="c"
                     /db_xref="dbSNP:1339832494"
     variation       1144
                     /replace="*"
                     /db_xref="dbSNP:138675881"
     variation       1144
                     /replace="p"
                     /db_xref="dbSNP:775709106"
     variation       1145
                     /replace="v"
                     /db_xref="dbSNP:1444132860"
     variation       1147
                     /replace="g"
                     /db_xref="dbSNP:760643121"
     variation       1148
                     /replace="y"
                     /db_xref="dbSNP:1246627721"
     variation       1149
                     /replace="m"
                     /db_xref="dbSNP:764430271"
     variation       1149
                     /replace="t"
                     /db_xref="dbSNP:538459863"
     variation       1150
                     /replace="g"
                     /db_xref="dbSNP:766211295"
     variation       1150
                     /replace="v"
                     /db_xref="dbSNP:762872915"
     variation       1151
                     /replace="l"
                     /db_xref="dbSNP:1460629643"
     variation       1153
                     /replace="q"
                     /db_xref="dbSNP:1167765854"
     variation       1155
                     /replace="y"
                     /db_xref="dbSNP:1319412351"
     variation       1156
                     /replace="d"
                     /db_xref="dbSNP:1416666590"
     variation       1156
                     /replace="n"
                     /db_xref="dbSNP:751557067"
     variation       1156
                     /replace="r"
                     /db_xref="dbSNP:1403340480"
     variation       1157
                     /replace="i"
                     /db_xref="dbSNP:755026372"
     variation       1157
                     /replace="t"
                     /db_xref="dbSNP:1215104945"
     variation       1158
                     /replace="*"
                     /db_xref="dbSNP:1381445771"
     variation       1158
                     /replace="t"
                     /db_xref="dbSNP:1367062284"
     variation       1160
                     /replace="f"
                     /db_xref="dbSNP:1435131111"
     variation       1161
                     /replace="q"
                     /db_xref="dbSNP:34743858"
     variation       1163
                     /replace="a"
                     /db_xref="dbSNP:4979"
     variation       1163
                     /replace="s"
                     /db_xref="dbSNP:1299150514"
     variation       1164
                     /replace="g"
                     /db_xref="dbSNP:755556171"
     variation       1164
                     /replace="r"
                     /db_xref="dbSNP:145579007"
     variation       1165
                     /replace="q"
                     /db_xref="dbSNP:1346793506"
     variation       1166
                     /replace="c"
                     /db_xref="dbSNP:777499791"
     variation       1166
                     /replace="h"
                     /db_xref="dbSNP:201126192"
     variation       1167
                     /replace="v"
                     /db_xref="dbSNP:1227093005"
     variation       1168
                     /replace="e"
                     /db_xref="dbSNP:993733529"
     variation       1168
                     /replace="t"
                     /db_xref="dbSNP:771285769"
     variation       1169
                     /replace="t"
                     /db_xref="dbSNP:202056228"
     variation       1170
                     /replace="a"
                     /db_xref="dbSNP:566409012"
     variation       1170
                     /replace="t"
                     /db_xref="dbSNP:747412511"
     variation       1171
                     /replace="l"
                     /db_xref="dbSNP:776634959"
     variation       1174
                     /replace="a"
                     /db_xref="dbSNP:754265941"
     variation       1174
                     /replace="d"
                     /db_xref="dbSNP:1458534207"
     variation       1176
                     /replace="s"
                     /db_xref="dbSNP:748236790"
     variation       1177
                     /replace="s"
                     /db_xref="dbSNP:1385800001"
     variation       1178
                     /replace="l"
                     /db_xref="dbSNP:538659872"
     variation       1178
                     /replace="p"
                     /db_xref="dbSNP:759423545"
     variation       1179
                     /replace="*"
                     /db_xref="dbSNP:1406482731"
     variation       1180
                     /replace="a"
                     /db_xref="dbSNP:767177049"
     variation       1180
                     /replace="l"
                     /db_xref="dbSNP:775501006"
     variation       1180
                     /replace="p"
                     /db_xref="dbSNP:376216920"
     variation       1183
                     /replace="i"
                     /db_xref="dbSNP:756739847"
     variation       1183
                     /replace="t"
                     /db_xref="dbSNP:753388395"
     variation       1183
                     /replace="v"
                     /db_xref="dbSNP:376826294"
     variation       1186
                     /replace="m"
                     /db_xref="dbSNP:764893306"
     variation       1187
                     /replace="m"
                     /db_xref="dbSNP:12709442"
     variation       1187
                     /replace="t"
                     /db_xref="dbSNP:141429845"
     variation       1188
                     /replace="d"
                     /db_xref="dbSNP:1396533675"
     variation       1188
                     /replace="g"
                     /db_xref="dbSNP:982649386"
     variation       1189
                     /replace="r"
                     /db_xref="dbSNP:1210452594"
     variation       1190
                     /replace="l"
                     /db_xref="dbSNP:1264163829"
     variation       1190
                     /replace="s"
                     /db_xref="dbSNP:1295931503"
     variation       1193
                     /replace="n"
                     /db_xref="dbSNP:780228220"
     variation       1193
                     /replace="s"
                     /db_xref="dbSNP:747389681"
     variation       1194
                     /replace="d"
                     /db_xref="dbSNP:777388821"
     variation       1194
                     /replace="t"
                     /db_xref="dbSNP:755506668"
     variation       1195
                     /replace="l"
                     /db_xref="dbSNP:748284095"
     variation       1195
                     /replace="p"
                     /db_xref="dbSNP:1343107612"
     variation       1195
                     /replace="s"
                     /db_xref="dbSNP:769941358"
     variation       1196
                     /replace="t"
                     /db_xref="dbSNP:773596097"
     variation       1197
                     /replace="v"
                     /db_xref="dbSNP:201870045"
     variation       1198
                     /replace="l"
                     /db_xref="dbSNP:1257665286"
     variation       1200
                     /replace="y"
                     /db_xref="dbSNP:771913893"
     variation       1201
                     /replace="l"
                     /db_xref="dbSNP:775204602"
     variation       1203
                     /replace="l"
                     /db_xref="dbSNP:369760270"
     variation       1203
                     /replace="p"
                     /db_xref="dbSNP:140280723"
     variation       1205
                     /replace="l"
                     /db_xref="dbSNP:1390560241"
     variation       1206
                     /replace="a"
                     /db_xref="dbSNP:1291258688"
     variation       1206
                     /replace="d"
                     /db_xref="dbSNP:1168139461"
     variation       1209
                     /replace="g"
                     /db_xref="dbSNP:1353694784"
     variation       1209
                     /replace="h"
                     /db_xref="dbSNP:538166970"
     variation       1210
                     /replace="a"
                     /db_xref="dbSNP:1304453464"
     variation       1210
                     /replace="r"
                     /db_xref="dbSNP:12720742"
     variation       1210
                     /replace="t"
                     /db_xref="dbSNP:138240046"
     variation       1211
                     /replace="*"
                     /db_xref="dbSNP:766053859"
     variation       1212
                     /replace="d"
                     /db_xref="dbSNP:996589954"
     variation       1212
                     /replace="n"
                     /db_xref="dbSNP:1271336698"
     variation       1212
                     /replace="t"
                     /db_xref="dbSNP:574717474"
     variation       1213
                     /replace="e"
                     /db_xref="dbSNP:781769416"
     variation       1213
                     /replace="k"
                     /db_xref="dbSNP:149590791"
     variation       1214
                     /replace="l"
                     /db_xref="dbSNP:890761035"
     variation       1214
                     /replace="p"
                     /db_xref="dbSNP:1451027689"
     variation       1215
                     /replace="h"
                     /db_xref="dbSNP:144312383"
     variation       1215
                     /replace="r"
                     /db_xref="dbSNP:757974064"
     variation       1217
                     /replace="*"
                     /db_xref="dbSNP:534095139"
     variation       1217
                     /replace="d"
                     /db_xref="dbSNP:1248102885"
     variation       1219
                     /replace="l"
                     /db_xref="dbSNP:749373274"
     variation       1219
                     /replace="p"
                     /db_xref="dbSNP:140941300"
     variation       1220
                     /replace="g"
                     /db_xref="dbSNP:1433516779"
     variation       1220
                     /replace="s"
                     /db_xref="dbSNP:1418538736"
     variation       1222
                     /replace="l"
                     /db_xref="dbSNP:779175881"
     variation       1222
                     /replace="p"
                     /db_xref="dbSNP:111576990"
     variation       1222
                     /replace="s"
                     /db_xref="dbSNP:144888208"
     variation       1223
                     /replace="q"
                     /db_xref="dbSNP:867518041"
     variation       1224
                     /replace="h"
                     /db_xref="dbSNP:776554544"
     variation       1224
                     /replace="y"
                     /db_xref="dbSNP:866250489"
     variation       1225
                     /replace="n"
                     /db_xref="dbSNP:1033103629"
     variation       1225
                     /replace="t"
                     /db_xref="dbSNP:761685671"
     Site            1225
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Not glycosylated. {ECO:0000269|PubMed:9013598};
                     propagated from UniProtKB/Swiss-Prot (P12821.1)"
     variation       1226
                     /replace="*"
                     /db_xref="dbSNP:769710002"
     variation       1227
                     /replace="a"
                     /db_xref="dbSNP:772778762"
     variation       1227
                     /replace="k"
                     /db_xref="dbSNP:762495578"
     variation       1227
                     /replace="t"
                     /db_xref="dbSNP:751171602"
     variation       1228
                     /replace="l"
                     /db_xref="dbSNP:121912703"
     variation       1228
                     /replace="p"
                     /db_xref="dbSNP:201117207"
     variation       1228
                     /replace="s"
                     /db_xref="dbSNP:967933744"
     variation       1229
                     /replace="s"
                     /db_xref="dbSNP:753269825"
     variation       1230
                     /replace="f"
                     /db_xref="dbSNP:756742824"
     variation       1230
                     /replace="s"
                     /db_xref="dbSNP:778419134"
     variation       1231
                     /replace="t"
                     /db_xref="dbSNP:959741765"
     variation       1231
                     /replace="v"
                     /db_xref="dbSNP:1241356540"
     variation       1232
                     /replace="c"
                     /db_xref="dbSNP:750545791"
     variation       1232
                     /replace="l"
                     /db_xref="dbSNP:372282664"
     variation       1232
                     /replace="r"
                     /db_xref="dbSNP:375754441"
     variation       1233
                     /replace="l"
                     /db_xref="dbSNP:1474601688"
     variation       1233
                     /replace="s"
                     /db_xref="dbSNP:1167676961"
     variation       1236
                     /replace="l"
                     /db_xref="dbSNP:751737727"
     variation       1236
                     /replace="p"
                     /db_xref="dbSNP:755904563"
     variation       1237
                     /replace="l"
                     /db_xref="dbSNP:1334187394"
     variation       1239
                     /replace="e"
                     /db_xref="dbSNP:749019292"
     variation       1239
                     /replace="g"
                     /db_xref="dbSNP:777561376"
     variation       1240
                     /replace="s"
                     /db_xref="dbSNP:757286547"
     variation       1241
                     /replace="s"
                     /db_xref="dbSNP:367916721"
     variation       1242
                     /replace="c"
                     /db_xref="dbSNP:1226490350"
     variation       1242
                     /replace="h"
                     /db_xref="dbSNP:781198085"
     variation       1242
                     /replace="r"
                     /db_xref="dbSNP:372143589"
     variation       1243
                     /replace="i"
                     /db_xref="dbSNP:372416620"
     variation       1244
                     /replace="i"
                     /db_xref="dbSNP:1261338191"
     variation       1245
                     /replace="f"
                     /db_xref="dbSNP:963984458"
     variation       1245
                     /replace="l"
                     /db_xref="dbSNP:531181910"
     variation       1248
                     /replace="l"
                     /db_xref="dbSNP:768181342"
     variation       1249
                     /replace="a"
                     /db_xref="dbSNP:777124668"
     variation       1250
                     /replace="v"
                     /db_xref="dbSNP:1193002337"
     variation       1251
                     /replace="ld"
                     /db_xref="dbSNP:780845846"
     variation       1252
                     /replace="a"
                     /db_xref="dbSNP:770384980"
     variation       1252
                     /replace="v"
                     /db_xref="dbSNP:762056936"
     variation       1253
                     /replace="*"
                     /db_xref="dbSNP:1174820268"
     variation       1254
                     /replace="e"
                     /db_xref="dbSNP:56038824"
     variation       1255
                     /replace="a"
                     /db_xref="dbSNP:773663364"
     variation       1256
                     /replace="c"
                     /db_xref="dbSNP:763049172"
     variation       1256
                     /replace="h"
                     /db_xref="dbSNP:766377685"
     variation       1256
                     /replace="r"
                     /db_xref="dbSNP:751789079"
     Site            1257..1277
                     /site_type="transmembrane region"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P12821.1)"
     variation       1257
                     /replace="m"
                     /db_xref="dbSNP:759857038"
     variation       1257
                     /replace="v"
                     /db_xref="dbSNP:767628762"
     variation       1258
                     /replace="d"
                     /db_xref="dbSNP:1434928128"
     variation       1258
                     /replace="g"
                     /db_xref="dbSNP:753706300"
     variation       1258
                     /replace="s"
                     /db_xref="dbSNP:1347084405"
     variation       1259
                     /replace="*"
                     /db_xref="dbSNP:1282502522"
     variation       1259
                     /replace="p"
                     /db_xref="dbSNP:756978461"
     variation       1259
                     /replace="q"
                     /db_xref="dbSNP:1239908508"
     variation       1263
                     /replace="l"
                     /db_xref="dbSNP:1262562180"
     variation       1264
                     /replace="f"
                     /db_xref="dbSNP:1348880297"
     variation       1266
                     /replace="d"
                     /db_xref="dbSNP:778929865"
     variation       1266
                     /replace="g"
                     /db_xref="dbSNP:1309203619"
     variation       1267
                     /replace="i"
                     /db_xref="dbSNP:144242912"
     variation       1268
                     /replace="a"
                     /db_xref="dbSNP:1197920248"
     variation       1268
                     /replace="t"
                     /db_xref="dbSNP:757997489"
     variation       1269
                     /replace="l"
                     /db_xref="dbSNP:369306676"
     variation       1269
                     /replace="l"
                     /db_xref="dbSNP:746513914"
     variation       1270
                     /replace="l"
                     /db_xref="dbSNP:768399209"
     variation       1270
                     /replace="p"
                     /db_xref="dbSNP:1179455074"
     variation       1271
                     /replace="i"
                     /db_xref="dbSNP:780690514"
     variation       1271
                     /replace="v"
                     /db_xref="dbSNP:748570561"
     variation       1272
                     /replace="a"
                     /db_xref="dbSNP:1452608632"
     variation       1272
                     /replace="g"
                     /db_xref="dbSNP:770016471"
     variation       1272
                     /replace="t"
                     /db_xref="dbSNP:1425238764"
     variation       1273
                     /replace="t"
                     /db_xref="dbSNP:1054697649"
     variation       1275
                     /replace="g"
                     /db_xref="dbSNP:1473244016"
     variation       1276
                     /replace="-"
                     /db_xref="dbSNP:1367232864"
     variation       1277
                     /replace="s"
                     /db_xref="dbSNP:1402919954"
     variation       1279
                     /replace="q"
                     /db_xref="dbSNP:4980"
     variation       1279
                     /replace="w"
                     /db_xref="dbSNP:568401628"
     variation       1281
                     /replace="f"
                     /db_xref="dbSNP:1042056760"
     variation       1281
                     /replace="s"
                     /db_xref="dbSNP:1393052928"
     variation       1283
                     /replace="v"
                     /db_xref="dbSNP:1268051765"
     variation       1284
                     /replace="c"
                     /db_xref="dbSNP:375527470"
     variation       1284
                     /replace="h"
                     /db_xref="dbSNP:1333987335"
     variation       1284
                     /replace="r"
                     /db_xref="dbSNP:1238643055"
     variation       1286
                     /replace="c"
                     /db_xref="dbSNP:4364"
     variation       1286
                     /replace="p"
                     /db_xref="dbSNP:767828019"
     variation       1286
                     /replace="r"
                     /db_xref="dbSNP:1220775181"
     variation       1287
                     /replace="g"
                     /db_xref="dbSNP:1291502122"
     variation       1289
                     /replace="h"
                     /db_xref="dbSNP:1481281618"
     variation       1289
                     /replace="r"
                     /db_xref="dbSNP:1004296792"
     variation       1290
                     /replace="q"
                     /db_xref="dbSNP:12720745"
     variation       1290
                     /replace="w"
                     /db_xref="dbSNP:752812293"
     variation       1291
                     /replace="h"
                     /db_xref="dbSNP:1217507273"
     variation       1292
                     /replace="s"
                     /db_xref="dbSNP:1417948787"
     variation       1293
                     /replace="h"
                     /db_xref="dbSNP:1013454628"
     variation       1293
                     /replace="y"
                     /db_xref="dbSNP:765069550"
     variation       1294
                     /replace="r"
                     /db_xref="dbSNP:1422356094"
     variation       1295
                     /replace="l"
                     /db_xref="dbSNP:886053226"
     variation       1296
                     /replace="*"
                     /db_xref="dbSNP:1162756119"
     variation       1296
                     /replace="r"
                     /db_xref="dbSNP:4981"
     variation       1297
                     /replace="f"
                     /db_xref="dbSNP:750229908"
     variation       1298
                     /replace="c"
                     /db_xref="dbSNP:1024799181"
     variation       1299
                     /replace="f"
                     /db_xref="dbSNP:1394448757"
     variation       1299
                     /replace="s"
                     /db_xref="dbSNP:780111755"
     Site            1299
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000269|PubMed:12386153};
                     propagated from UniProtKB/Swiss-Prot (P12821.1)"
     variation       1300
                     /replace="d"
                     /db_xref="dbSNP:1244045213"
     variation       1300
                     /replace="g"
                     /db_xref="dbSNP:1385347177"
     variation       1300
                     /replace="k"
                     /db_xref="dbSNP:751134637"
     variation       1301
                     /replace="v"
                     /db_xref="dbSNP:1314816029"
     variation       1302
                     /replace="e"
                     /db_xref="dbSNP:4365"
     variation       1303
                     /replace="l"
                     /db_xref="dbSNP:1207267524"
     variation       1304
                     /replace="k"
                     /db_xref="dbSNP:1016285379"
     variation       1305
                     /replace="h"
                     /db_xref="dbSNP:1250173627"
     variation       1306
                     /replace="s"
                     /db_xref="dbSNP:1480573228"
     CDS             1..1306
                     /gene="ACE"
                     /gene_synonym="ACE1; CD143; DCP; DCP1"
                     /coded_by="NM_000789.4:35..3955"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS11637.1"
                     /db_xref="GeneID:1636"
                     /db_xref="HGNC:HGNC:2707"
                     /db_xref="MIM:106180"
ORIGIN      
        1 mgaasgrrgp glllplplll llppqpalal dpglqpgnfs adeagaqlfa qsynssaeqv
       61 lfqsvaaswa hdtnitaena rrqeeaalls qefaeawgqk akelyepiwq nftdpqlrri
      121 igavrtlgsa nlplakrqqy nallsnmsri ystakvclpn ktatcwsldp dltnilassr
      181 syamllfawe gwhnaagipl kplyedftal sneaykqdgf tdtgaywrsw ynsptfeddl
      241 ehlyqqlepl ylnlhafvrr alhrrygdry inlrgpipah llgdmwaqsw eniydmvvpf
      301 pdkpnldvts tmlqqgwnat hmfrvaeeff tslelspmpp efwegsmlek padgrevvch
      361 asawdfynrk dfrikqctrv tmdqlstvhh emghiqyylq ykdlpvslrr ganpgfheai
      421 gdvlalsvst pehlhkigll drvtndtesd inyllkmale kiaflpfgyl vdqwrwgvfs
      481 grtppsrynf dwwylrtkyq gicppvtrne thfdagakfh vpnvtpyiry fvsfvlqfqf
      541 healckeagy egplhqcdiy rstkagaklr kvlqagssrp wqevlkdmvg ldaldaqpll
      601 kyfqpvtqwl qeqnqqngev lgwpeyqwhp plpdnypegi dlvtdeaeas kfveeydrts
      661 qvvwneyaea nwnyntnitt etskillqkn mqianhtlky gtqarkfdvn qlqnttikri
      721 ikkvqdlera alpaqeleey nkilldmett ysvatvchpn gsclqlepdl tnvmatsrky
      781 edllwawegw rdkagrailq fypkyvelin qaarlngyvd agdswrsmye tpsleqdler
      841 lfqelqplyl nlhayvrral hrhygaqhin legpipahll gnmwaqtwsn iydlvvpfps
      901 apsmdtteam lkqgwtprrm fkeaddffts lgllpvppef wnksmlekpt dgrevvchas
      961 awdfyngkdf rikqcttvnl edlvvahhem ghiqyfmqyk dlpvalrega npgfheaigd
     1021 vlalsvstpk hlhslnllss eggsdehdin flmkmaldki afipfsylvd qwrwrvfdgs
     1081 itkenynqew wslrlkyqgl cppvprtqgd fdpgakfhip ssvpyiryfv sfiiqfqfhe
     1141 alcqaaghtg plhkcdiyqs keagqrlata mklgfsrpwp eamqlitgqp nmsasamlsy
     1201 fkplldwlrt enelhgeklg wpqynwtpns arsegplpds grvsflgldl daqqarvgqw
     1261 lllflgiall vatlglsqrl fsirhrslhr hshgpqfgse velrhs
//
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