LOCUS NP_000880 798 aa linear PRI 18-SEP-2023
DEFINITION integrin beta-7 isoform a precursor [Homo sapiens].
ACCESSION NP_000880
VERSION NP_000880.1
DBSOURCE REFSEQ: accession NM_000889.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 798)
AUTHORS Roy Choudhury S, Byrum SD, Alkam D, Ashby C, Zhan F, Tackett AJ and
Van Rhee F.
TITLE Expression of integrin beta-7 is epigenetically enhanced in
multiple myeloma subgroups with high-risk cytogenetics
JOURNAL Clin Epigenetics 15 (1), 18 (2023)
PUBMED 36737807
REMARK GeneRIF: Expression of integrin beta-7 is epigenetically enhanced
in multiple myeloma subgroups with high-risk cytogenetics.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 798)
AUTHORS Xu T, Liu J, Xia Y, Wang Z, Li X and Gao Q.
TITLE Integrated analysis reveals the participation of IL4I1, ITGB7, and
FUT7 in reshaping the TNBC immune microenvironment by targeting
glycolysis
JOURNAL Ann Med 53 (1), 916-928 (2021)
PUBMED 34134578
REMARK GeneRIF: Integrated analysis reveals the participation of IL4I1,
ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by
targeting glycolysis.
REFERENCE 3 (residues 1 to 798)
AUTHORS Hosen N, Yoshihara S, Takamatsu H, Ri M, Nagata Y, Kosugi H,
Shimomura Y, Hanamura I, Fuji S, Minauchi K, Kuroda J, Suzuki R,
Nishimura N, Uoshima N, Nakamae H, Kawano Y, Mizuno I, Gomyo H,
Suzuki K, Ozaki S, Nakamura S, Imai Y, Kizaki M, Negoro E, Handa H
and Iida S.
TITLE Expression of activated integrin beta7 in multiple myeloma patients
JOURNAL Int J Hematol 114 (1), 3-7 (2021)
PUBMED 33999338
REMARK GeneRIF: Expression of activated integrin beta7 in multiple myeloma
patients.
REFERENCE 4 (residues 1 to 798)
AUTHORS Mora JR, Bono MR, Manjunath N, Weninger W, Cavanagh LL, Rosemblatt
M and Von Andrian UH.
TITLE Selective imprinting of gut-homing T cells by Peyer's patch
dendritic cells
JOURNAL Nature 424 (6944), 88-93 (2003)
PUBMED 12840763
REFERENCE 5 (residues 1 to 798)
AUTHORS Erle DJ, Brown T, Christian D and Aris R.
TITLE Lung epithelial lining fluid T cell subsets defined by distinct
patterns of beta 7 and beta 1 integrin expression
JOURNAL Am J Respir Cell Mol Biol 10 (3), 237-244 (1994)
PUBMED 7509610
REFERENCE 6 (residues 1 to 798)
AUTHORS Jiang WM, Jenkins D, Yuan Q, Leung E, Choo KH, Watson JD and
Krissansen GW.
TITLE The gene organization of the human beta 7 subunit, the common beta
subunit of the leukocyte integrins HML-1 and LPAM-1
JOURNAL Int Immunol 4 (9), 1031-1040 (1992)
PUBMED 1382574
REFERENCE 7 (residues 1 to 798)
AUTHORS Ruegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R and Erle DJ.
TITLE Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte
adherence to fibronectin and VCAM-1 and in homotypic cell
clustering
JOURNAL J Cell Biol 117 (1), 179-189 (1992)
PUBMED 1372909
REFERENCE 8 (residues 1 to 798)
AUTHORS Parker CM, Cepek KL, Russell GJ, Shaw SK, Posnett DN, Schwarting R
and Brenner MB.
TITLE A family of beta 7 integrins on human mucosal lymphocytes
JOURNAL Proc Natl Acad Sci U S A 89 (5), 1924-1928 (1992)
PUBMED 1542691
REFERENCE 9 (residues 1 to 798)
AUTHORS Baker E, Sutherland GR, Jiang WM, Yuan Q, Leung E, Watson JD and
Krissansen GW.
TITLE Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13
by non-isotopic in situ hybridization
JOURNAL Mamm Genome 2 (4), 272-273 (1992)
PUBMED 1543919
REFERENCE 10 (residues 1 to 798)
AUTHORS Erle DJ, Ruegg C, Sheppard D and Pytela R.
TITLE Complete amino acid sequence of an integrin beta subunit (beta 7)
identified in leukocytes
JOURNAL J Biol Chem 266 (17), 11009-11016 (1991)
PUBMED 2040616
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC296007.1 and S80335.1.
Summary: This gene encodes a protein that is a member of the
integrin superfamily. Members of this family are adhesion receptors
that function in signaling from the extracellular matrix to the
cell. Integrins are heterodimeric integral membrane proteins
composed of an alpha chain and a beta chain. The encoded protein
forms dimers with an alpha4 chain or an alphaE chain and plays a
role in leukocyte adhesion. Dimerization with alpha4 forms a homing
receptor for migration of lymphocytes to the intestinal mucosa and
Peyer's patches. Dimerization with alphaE permits binding to the
ligand epithelial cadherin, a calcium-dependent adhesion molecule.
Alternate splicing results in multiple transcript variants.
Additional alternatively spliced transcript variants of this gene
have been described, but their full-length nature is not known.
[provided by RefSeq, Sep 2013].
Transcript Variant: This variant (1) encodes the longest isoform
(a). Variants 1 and 3-8 all encode the same isoform (a).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: S80335.1, SRR1163655.140810.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000267082.10/ ENSP00000267082.4
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..798
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q13.13"
Protein 1..798
/product="integrin beta-7 isoform a precursor"
/note="integrin beta-7; integrin beta 7 subunit; gut
homing receptor beta subunit"
/calculated_mol_wt=84881
sig_peptide 1..19
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2041
mat_peptide 20..798
/product="Integrin beta-7. /id=PRO_0000016352"
/note="propagated from UniProtKB/Swiss-Prot (P26010.1)"
/calculated_mol_wt=84881
Region 50..476
/region_name="INB"
/note="Integrin beta subunits (N-terminal portion of
extracellular region); smart00187"
/db_xref="CDD:197563"
Site 68
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26010.1)"
Region 98..124
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P26010.1)"
Site 279
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:22232704,
ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V; propagated
from UniProtKB/Swiss-Prot (P26010.1)"
Site 434
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:22232704,
ECO:0007744|PDB:3V4V; propagated from UniProtKB/Swiss-Prot
(P26010.1)"
Region 476..506
/region_name="I-EGF_1"
/note="Integrin beta epidermal growth factor like domain
1; pfam18372"
/db_xref="CDD:436446"
Site 477
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26010.1)"
Site 531
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26010.1)"
Site 590
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26010.1)"
Region 645..717
/region_name="Integrin_B_tail"
/note="Integrin beta tail domain; pfam07965"
/db_xref="CDD:429757"
Site 665
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26010.1)"
Site 674
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P26010.1)"
Site 724..746
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P26010.1)"
Region 747..790
/region_name="Integrin_b_cyt"
/note="Integrin beta cytoplasmic domain; pfam08725"
/db_xref="CDD:430176"
Site 778
/site_type="phosphorylation"
/note="Phosphotyrosine, by Tyr-kinases.
/evidence=ECO:0000250; propagated from
UniProtKB/Swiss-Prot (P26010.1)"
CDS 1..798
/gene="ITGB7"
/coded_by="NM_000889.3:177..2573"
/note="isoform a precursor is encoded by transcript
variant 1"
/db_xref="CCDS:CCDS8849.1"
/db_xref="GeneID:3695"
/db_xref="HGNC:HGNC:6162"
/db_xref="MIM:147559"
ORIGIN
1 mvalpmvlvl llvlsrgese ldakipstgd atewrnphls mlgscqpaps cqkcilshps
61 cawckqlnft asgeaearrc arreellarg cpleeleepr gqqevlqdqp lsqgargega
121 tqlapqrvrv tlrpgepqql qvrflraegy pvdlyylmdl sysmkddler vrqlghallv
181 rlqevthsvr igfgsfvdkt vlpfvstvps klrhpcptrl ercqspfsfh hvlsltgdaq
241 aferevgrqs vsgnldspeg gfdailqaal cqeqigwrnv srllvftsdd tfhtagdgkl
301 ggifmpsdgh chldsnglys rstefdypsv gqvaqalsaa niqpifavts aalpvyqels
361 klipksavge lsedssnvvq limdaynsls stvtlehssl ppgvhisyes qcegpekreg
421 kaedrgqcnh vrinqtvtfw vslqathclp ephllrlral gfseelivel htlcdcncsd
481 tqpqaphcsd gqghlqcgvc scapgrlgrl cecsvaelss pdlesgcrap ngtgplcsgk
541 ghcqcgrcsc sgqssghlce cddascerhe gilcggfgrc qcgvchchan rtgracecsg
601 dmdscispeg glcsghgrck cnrcqcldgy ygalcdqcpg cktpcerhrd caecgafrtg
661 platncstac ahtnvtlala pilddgwcke rtldnqlfff lveddargtv vlrvrpqekg
721 adhtqaivlg cvggivavgl glvlayrlsv eiydrreysr fekeqqqlnw kqdsnplyks
781 aitttinprf qeadsptl
//
