LOCUS NP_001003718 2774 aa linear VRT 24-SEP-2023
DEFINITION teneurin-2 isoform 2 [Gallus gallus].
ACCESSION NP_001003718 XP_040502733
VERSION NP_001003718.2
DBSOURCE REFSEQ: accession NM_001003718.2
KEYWORDS RefSeq.
SOURCE Gallus gallus (chicken)
ORGANISM Gallus gallus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
REFERENCE 1 (residues 1 to 2774)
AUTHORS Tang H, Finn RD and Thomas PD.
TITLE TreeGrafter: phylogenetic tree-based annotation of proteins with
Gene Ontology terms and other annotations
JOURNAL Bioinformatics 35 (3), 518-520 (2019)
PUBMED 30032202
REFERENCE 2 (residues 1 to 2774)
AUTHORS Burge S, Kelly E, Lonsdale D, Mutowo-Muellenet P, McAnulla C,
Mitchell A, Sangrador-Vegas A, Yong SY, Mulder N and Hunter S.
TITLE Manual GO annotation of predictive protein signatures: the InterPro
approach to GO curation
JOURNAL Database (Oxford) 2012, bar068 (2012)
PUBMED 22301074
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 2774)
AUTHORS Kenzelmann D, Chiquet-Ehrismann R, Leachman NT and Tucker RP.
TITLE Teneurin-1 is expressed in interconnected regions of the developing
brain and is processed in vivo
JOURNAL BMC Dev Biol 8, 30 (2008)
PUBMED 18366734
REMARK GeneRIF: Teneurin-1 and -2 are expressed by distinct interconnected
populations of neurons in the developing central nervous system
Publication Status: Online-Only
REFERENCE 4 (residues 1 to 2774)
AUTHORS Bagutti C, Forro G, Ferralli J, Rubin B and Chiquet-Ehrismann R.
TITLE The intracellular domain of teneurin-2 has a nuclear function and
represses zic-1-mediated transcription
JOURNAL J Cell Sci 116 (Pt 14), 2957-2966 (2003)
PUBMED 12783990
REFERENCE 5 (residues 1 to 2774)
AUTHORS Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong
WT, Tickle C, Brown WR, Wilson SA and Hubbard SJ.
TITLE A comprehensive collection of chicken cDNAs
JOURNAL Curr Biol 12 (22), 1965-1969 (2002)
PUBMED 12445392
REFERENCE 6 (residues 1 to 2774)
AUTHORS Rubin BP, Tucker RP, Brown-Luedi M, Martin D and Chiquet-Ehrismann
R.
TITLE Teneurin 2 is expressed by the neurons of the thalamofugal visual
system in situ and promotes homophilic cell-cell adhesion in vitro
JOURNAL Development 129 (20), 4697-4705 (2002)
PUBMED 12361962
REFERENCE 7 (residues 1 to 2774)
AUTHORS Tucker RP, Chiquet-Ehrismann R, Chevron MP, Martin D, Hall RJ and
Rubin BP.
TITLE Teneurin-2 is expressed in tissues that regulate limb and somite
pattern formation and is induced in vitro and in situ by FGF8
JOURNAL Dev Dyn 220 (1), 27-39 (2001)
PUBMED 11146505
REFERENCE 8 (residues 1 to 2774)
AUTHORS Rubin BP, Tucker RP, Martin D and Chiquet-Ehrismann R.
TITLE Teneurins: a novel family of neuronal cell surface proteins in
vertebrates, homologous to the Drosophila pair-rule gene product
Ten-m
JOURNAL Dev Biol 216 (1), 195-209 (1999)
PUBMED 10588872
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAENSK010000256.1.
On or before Dec 16, 2021 this sequence version replaced
XP_040502733.1, NP_001003718.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on transcript alignments.
##Evidence-Data-START##
RNAseq introns :: mixed sample support SAMEA103992290,
SAMEA103992323 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
inferred exon combination :: based on alignments, homology
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..2774
/organism="Gallus gallus"
/db_xref="taxon:9031"
/chromosome="13"
/map="13"
Protein 1..2774
/product="teneurin-2 isoform 2"
/note="teneurin-2; odd Oz/ten-m homolog 2; ten-2; ten-m2;
neurestin; tenascin-M2; protein Odd Oz/ten-m homolog 2;
odz, odd Oz/ten-m homolog 2"
/calculated_mol_wt=307343
Region 10..374
/region_name="Ten_N"
/note="Teneurin Intracellular Region; pfam06484"
/db_xref="CDD:428971"
Site 380..400
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 418..454
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 443
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 482
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 528..529
/site_type="cleavage"
/note="Cleavage. /evidence=ECO:0000305; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 575..734
/region_name="DUF5885"
/note="Family of unknown function (DUF5885); pfam19232"
/db_xref="CDD:437064"
Region <755..796
/region_name="DSL"
/note="Delta serrate ligand; cl19567"
/db_xref="CDD:450329"
Site 925
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 948
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1240..1570
/region_name="NHL"
/note="NHL repeat unit of beta-propeller proteins;
cl18310"
/db_xref="CDD:302697"
Region 1240..1279
/region_name="NHL repeat"
/note="NHL repeat [structural motif]"
/db_xref="CDD:271320"
Site 1267
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1272..1316
/region_name="NHL 1"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1291..1334
/region_name="NHL repeat"
/note="NHL repeat [structural motif]"
/db_xref="CDD:271320"
Region 1342..1386
/region_name="NHL 2"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1358..1396
/region_name="NHL repeat"
/note="NHL repeat [structural motif]"
/db_xref="CDD:271320"
Region 1401..1452
/region_name="NHL 3"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1414..1453
/region_name="NHL repeat"
/note="NHL repeat [structural motif]"
/db_xref="CDD:271320"
Region 1474..1501
/region_name="NHL 4"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1476..1509
/region_name="NHL repeat"
/note="NHL repeat [structural motif]"
/db_xref="CDD:271320"
Region 1530..1573
/region_name="NHL 5"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region <1544..>1598
/region_name="NHL"
/note="NHL repeat unit of beta-propeller proteins;
cl18310"
/db_xref="CDD:302697"
Region 1544..1570
/region_name="NHL repeat"
/note="NHL repeat [structural motif]"
/db_xref="CDD:271320"
Region 1546..1582
/region_name="NHL repeat"
/note="NHL repeat [structural motif]"
/db_xref="CDD:271320"
Region 1583..1602
/region_name="YD 1"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 1616
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1619..1639
/region_name="YD 2"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1682..1701
/region_name="YD 3"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1689..2454
/region_name="RhsA"
/note="Uncharacterized conserved protein RhsA, contains 28
RHS repeats [General function prediction only]; COG3209"
/db_xref="CDD:225750"
Region 1702..1724
/region_name="YD 4"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 1712
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 1749
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 1773
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 1807
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 1892
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1895..1914
/region_name="YD 5"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1936..1954
/region_name="YD 6"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1955..1975
/region_name="YD 7"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 1982..1999
/region_name="YD 8"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 1993
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2000..2021
/region_name="YD 9"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2022..2039
/region_name="YD 10"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2042..2062
/region_name="YD 11"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2065..2085
/region_name="YD 12"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2093..2113
/region_name="YD 13"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2119..2136
/region_name="YD 14"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2137..2163
/region_name="YD 15"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2165..2178
/region_name="YD 16"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2179..2202
/region_name="YD 17"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 2197
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2205..2225
/region_name="YD 18"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2226..2246
/region_name="YD 19"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2248..2268
/region_name="YD 20"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2280..2300
/region_name="YD 21"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2302..2322
/region_name="YD 22"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Site 2337
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2348..2389
/region_name="YD 23"
/note="propagated from UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2391..2468
/region_name="Rhs_assc_core"
/note="RHS repeat-associated core domain; TIGR03696"
/db_xref="CDD:274730"
Site 2648
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9DER5.1)"
Region 2690..2767
/region_name="Tox-GHH"
/note="GHH signature containing HNH/Endo VII superfamily
nuclease toxin; pfam15636"
/db_xref="CDD:434826"
CDS 1..2774
/gene="TENM2"
/gene_synonym="ODZ2; TEN2"
/coded_by="NM_001003718.2:390..8714"
/note="isoform 2 is encoded by transcript variant 2"
/db_xref="CGNC:1242"
/db_xref="GeneID:373854"
ORIGIN
1 mdikdrrhrs ltrgrcgkec rytsssldse dcrvptqksy sssetlkayd hdtrmhygnr
61 vsdlvhresd efprqgtnft laelgiceps phrsgycsdi gilhqgysls tgsdadsdte
121 ggmspehair lwgrgiksrr ssglssrens altltdsdne nksdeengrp ipptssssll
181 psaqlpsshn pppvscqmpl ldsntshqim dtnpdeefsp nsyllracsg pqqasssgps
241 nhhsqstlrp plppphnhsl shhhssansl nrnsltnrrn qihapapapn dlattpesvq
301 lqdswvlnsn vpletrhflf ktssgttplf sssspgyplt sgtvytpppr llprntfsrn
361 afklkkpsky cswkcaalsa iaaavllail layfiamhll glnwqlqpad ghtfsnglrp
421 gaagaedgaa appagrgpwv trnssidsge tevgrkvtqe vppgvfwrsq ihisqpqflk
481 fnislgkdal fgvyirrglp pshaqydfme rldgkekwsv vesprerrsi qtlvqneavf
541 vqyldvglwh lafyndgkdk evvsfstvil dsvqdcprnc hgngecvsgv chcfpgfhga
601 dcakaacpvl csgngqyskg tclcysgwkg pecdvpisqc idpscgghgs ciegncvcsi
661 gykgenceev dcldptcsnh gvcvngeclc spgwggince lpraqcpdqc sghgtylsdt
721 glcscdpnwm gpdcsvevcs vdcgthgvci ggacrceegw tgvacdqrvc hprctehgtc
781 kdgkcecreg wngehctigr qttgtetdgc pdlcngngrc tlgqnswqcv cqtgwrgpgc
841 nvametscad nkdnegdglv dcldpdcclq stcqnsllcr gsrdpldviq qshsgspavk
901 sfydrikllv gkdsthiipg enpfnsslvs lirgqvvttd gtplvgvnvs fvkypkygyt
961 itrqdgmfdl vanggssltl hferapfmsq ertvwlpwns fyamdtlvmk teensipscd
1021 lsgfvrpdpv iissplstff sdapgrnpiv petqvlheei evpgssikli ylssrtagyk
1081 sllkiimtqs lvplnlikvh lmvaveghlf qksflaspnl aytfiwdktd aygqkvygls
1141 davvsvgfey etcpslilwe krtallqgfe ldpsnlggws ldkhhvlnvk sgilhkgnge
1201 nqfltqqpav itsimgngrr rsiscpscng laegnkllap valavgidgs lfvgdfnyir
1261 rifpsrnvts ilelrnkefk hsnnpahkyy lavdpvsgsl yvsdtnsrri ykvksltgtk
1321 dlagnsevva gtgeqclpfd earcgdggka vdatlmsprg iavdkyglmy fvdatmirkv
1381 dqngiistll gsndltavrp lscdssmdvs qvrlewptdl avnpmdnsly vlennvilri
1441 tenhqvsiia grpmhcqvpg idyslsklai hsalesasai aishtgvlyi setdekkinr
1501 lrqvttngei cllagaasdc dckndvncnc ysgddgyatd ailnspssla vapdgtiyia
1561 dlgnirirav sknrpilnsf nqyeaaspge qelyvfnadg ihqytlslvt geylynftys
1621 sdndvtevmd sngnslkvrr dasgmprhll mpdnqivtla vgtngglklv stqtlelglm
1681 tyngnsglla tksdetgwtt fydydhegrl tnvtrptgvv tslhremeks itidiensnr
1741 dddvtvitnl ssveasytvv qdqvrnsyql cnngtlrvmy angmsisfhs ephvlagtvt
1801 ptigrcnisl pmenglnsie wrlrkeqikg kvtvfgrklr vhgrnllsid ydrnirteki
1861 yddhrkftlr iiydqlgrpf lwlpssglaa vnvsyffngr laglqrgams ertdidkqgr
1921 iisrmfadgk vwsytyleks mvlllqsqrq yifeydssdr lhavtmpsva rhsmsthtsv
1981 gyirniynpp esnasvifdy sddgrilkts flgtgrqvfy kygklsklse ivydstavtf
2041 gydettgvlk mvnlqsggfs ctiryrkigp lvdkqiyrfs eegmvnarfd ytyhdnsfri
2101 asikpiiset plpvdlyryd eisgkvehfg kfgviyydin qiittavmtl skhfdthgri
2161 kevqyemfrs lmywmtvqyd smgrvtkrel klgpyanttk ytydydgdgq lqsvavndrp
2221 twrysydlng nlhllnpgns vrlmplrydl rdritrlgdi pykidddgfl cqrgsdvfey
2281 nskglltray nkangwnvqy rydglgrras cktnlghhlq yfyadlhnpt rvthvynhsn
2341 seitslyydl qghlfamess sgeeyyvasd ntgtplavfs inglmikqlq ytaygeiyyd
2401 snpdfqlvig fhgglydplt klvhftqrdy dvlagrwtsp dytmwknigr epapfnlymf
2461 ksnnplsnel dlknyvtdvk swlvmfgfql sniipgfpra kmyfvsppye ltesqaceng
2521 qlitgvqqtt erhnqafmal egqviskrlh asirekaghw fatstpiigk gimfavkegr
2581 vttgissiat ddsrkiasvl nsahylekmh ysiegkdthy fvkigsadsd lvtlamtsgr
2641 kvldsgvnvt vsqptlling rtrrftnief qystllinir ygltadtlde ekarvldqar
2701 qralgsawak eqqkardgre gsrvwtdgek qqllntgrvq gyegyyvlpv eqypeladss
2761 sniqflrqne mgkr
//
