LOCUS NP_001004728 315 aa linear PRI 30-APR-2025
DEFINITION olfactory receptor 5A1 [Homo sapiens].
ACCESSION NP_001004728 XP_166899
VERSION NP_001004728.1
DBSOURCE REFSEQ: accession NM_001004728.2
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 315)
AUTHORS Malnic,B., Godfrey,P.A. and Buck,L.B.
TITLE The human olfactory receptor gene family
JOURNAL Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
PUBMED 14983052
REMARK Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE 2 (residues 1 to 315)
AUTHORS Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
Lehrach,H., Lancet,D. and Shamir,R.
TITLE DEFOG: a practical scheme for deciphering families of genes
JOURNAL Genomics 80 (3), 295-302 (2002)
PUBMED 12213199
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AP003778.3.
On Sep 19, 2004 this sequence version replaced XP_166899.3.
Summary: Olfactory receptors interact with odorant molecules in the
nose, to initiate a neuronal response that triggers the perception
of a smell. The olfactory receptor proteins are members of a large
family of G-protein-coupled receptors (GPCR) arising from single
coding-exon genes. Olfactory receptors share a 7-transmembrane
domain structure with many neurotransmitter and hormone receptors
and are responsible for the recognition and G protein-mediated
transduction of odorant signals. The olfactory receptor gene family
is the largest in the genome. [provided by RefSeq, Jul 2008].
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000641045.1/ ENSP00000493195.1
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..315
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q12.1"
Protein 1..315
/product="olfactory receptor 5A1"
/note="olfactory receptor, family 5, subfamily A, member 1
pseudogene; olfactory receptor OR11-249"
/calculated_mol_wt=35021
Site 8
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q8NGJ0.1)"
Region 29..306
/region_name="7tmA_OR5A1-like"
/note="olfactory receptor subfamily 5A1 and related
proteins, member of the class A family of
seven-transmembrane G protein-coupled receptors; cd15417"
/db_xref="CDD:320539"
Region 29..55
/region_name="TM helix 1"
/note="TM helix 1 [structural motif]"
/db_xref="CDD:320539"
Site 29..52
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ0.1)"
Site 61..82
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ0.1)"
Region 62..88
/region_name="TM helix 2"
/note="TM helix 2 [structural motif]"
/db_xref="CDD:320539"
Site order(84,87..88,100..105,107..108,111,156,158..162,198,
201..203,205..207,209..210,255,258..259,261..262,265,
271..272,274..276,279,282..283)
/site_type="other"
/note="putative ligand binding pocket [chemical binding]"
/db_xref="CDD:320539"
Region 100..130
/region_name="TM helix 3"
/note="TM helix 3 [structural motif]"
/db_xref="CDD:320539"
Site 104..123
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ0.1)"
Region 143..164
/region_name="TM helix 4"
/note="TM helix 4 [structural motif]"
/db_xref="CDD:320539"
Site 143..161
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ0.1)"
Region 198..228
/region_name="TM helix 5"
/note="TM helix 5 [structural motif]"
/db_xref="CDD:320539"
Site 199..222
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ0.1)"
Region 235..265
/region_name="TM helix 6"
/note="TM helix 6 [structural motif]"
/db_xref="CDD:320539"
Site 240..262
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ0.1)"
Region 272..297
/region_name="TM helix 7"
/note="TM helix 7 [structural motif]"
/db_xref="CDD:320539"
Site 276..295
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (Q8NGJ0.1)"
CDS 1..315
/gene="OR5A1"
/gene_synonym="OR11-249; OR5A1P; OST181"
/coded_by="NM_001004728.2:401..1348"
/db_xref="CCDS:CCDS31561.1"
/db_xref="GeneID:219982"
/db_xref="HGNC:HGNC:8319"
ORIGIN
1 msitkawnss svtmfillgf tdhpelqall fvtflgiylt tlawnlalif lirgdthlht
61 pmyfflsnls fidicyssav apnmltdffw eqktisfvgc aaqffffvgm glseclllta
121 maydryaais spllyptimt qglctrmvvg ayvggflssl iqassifrlh fcgpniinhf
181 fcdlppvlal scsdtflsqv vnflvvvtvg gtsflqllis ygyivsavlk ipsaegrwka
241 cntcashlmv vtllfgtalf vylrpsssyl lgrdkvvsvf yslvipmlnp liyslrnkei
301 kdalwkvler kkvfs
//
