GenomeNet

Database: RefSeq
Entry: NP_001009547
LinkDB: NP_001009547
Original site: NP_001009547 
LOCUS       NP_001009547             699 aa            linear   ROD 26-MAY-2018
DEFINITION  a disintegrin and metalloprotease domain 26b precursor [Mus
            musculus].
ACCESSION   NP_001009547 XP_356073
VERSION     NP_001009547.1
DBSOURCE    REFSEQ: accession NM_001009547.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 699)
  AUTHORS   Grayson P and Civetta A.
  TITLE     Positive selection in the adhesion domain of Mus sperm Adam genes
            through gene duplications and function-driven gene complex
            formations
  JOURNAL   BMC Evol. Biol. 13, 217 (2013)
   PUBMED   24079728
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 699)
  AUTHORS   Choi I, Oh J, Cho BN, Ahnn J, Jung YK, Han Kim D and Cho C.
  TITLE     Characterization and comparative genomic analysis of intronless
            Adams with testicular gene expression
  JOURNAL   Genomics 83 (4), 636-646 (2004)
   PUBMED   15028286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK015931.1 and AC134907.5.
            On Jan 12, 2005 this sequence version replaced XP_356073.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and paralogous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8"
     Protein         1..699
                     /product="a disintegrin and metalloprotease domain 26b
                     precursor"
                     /calculated_mol_wt=76336
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2668
     Region          39..144
                     /region_name="Pep_M12B_propep"
                     /note="Reprolysin family propeptide; pfam01562"
                     /db_xref="CDD:279848"
     Region          195..385
                     /region_name="Reprolysin"
                     /note="Reprolysin (M12B) family zinc metalloprotease;
                     pfam01421"
                     /db_xref="CDD:279729"
     Region          195..383
                     /region_name="ZnMc_adamalysin_II_like"
                     /note="Zinc-dependent metalloprotease; adamalysin_II_like
                     subfamily. Adamalysin II is a snake venom zinc
                     endopeptidase. This subfamily contains other snake venom
                     metalloproteinases, as well as membrane-anchored
                     metalloproteases belonging to the ADAM family; cd04269"
                     /db_xref="CDD:239797"
     Site            order(329..330,333,339)
                     /site_type="active"
                     /db_xref="CDD:239797"
     Region          401..474
                     /region_name="Disintegrin"
                     /note="Disintegrin; pfam00200"
                     /db_xref="CDD:278623"
     Region          477..613
                     /region_name="ACR"
                     /note="ADAM Cysteine-Rich Domain; smart00608"
                     /db_xref="CDD:214743"
     CDS             1..699
                     /gene="Adam26b"
                     /coded_by="NM_001009547.2:306..2405"
                     /db_xref="CCDS:CCDS22268.1"
                     /db_xref="GeneID:382007"
                     /db_xref="MGI:MGI:3588304"
ORIGIN      
        1 mflkfclwtm fffsawspig hakysslpev vtplrvtvtr gnntspgwls yslniggqrh
       61 iitmkpkknl msrnlillty tqqgdlleqr pfvpndcyyh gyvdedpesl vilntcfgsl
      121 qgtleingtt yeimpkssts tfehlaykmd ngdsepspmr cglseeeiaq qrklrernap
      181 tllqiphenw wthhrfieyf vvidhkqyvh rnnnittciq dmlqivngvn gyylqidtdv
      241 vltaleiwne knyinvelsi fkvlgdfctw kqnmfgnrir hdiihllvrq gyglylglay
      301 ladvctpync gvssflsdvm sdmahivahe mghnlgmkhd gigctcglkd clmapyktns
      361 pkfsncsyee mysvvtkrsc lydipealvt nltvcgnkvv eegeecdcgs tesclqdpcc
      421 ssdcvlkpga qcafglccqd cqflktgtvc reeknecdlp ewcngtsaec pgdvykadgi
      481 pcsgegycyk mechqrdeqc rkifgngsrs adeicymemn rrgdrfgncg ndsskykice
      541 ladvlcgriq cenviqlpqr rnhetvhyth fsnvtcwtmd yhfgitiddi gavsdgtaca
      601 pyhicvdrkc vsksdlvsnc ttklchmqgv cnnknhchct ntweppdcql rghggsldsg
      661 ppplhvpnss wafyfisfft illvitislv gitkrvkmn
//
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