LOCUS       NP_001017560             433 aa            linear   VRT 17-DEC-2022
DEFINITION  glycosyltransferase-like domain-containing protein 1 [Danio rerio].
ACCESSION   NP_001017560 XP_701787
VERSION     NP_001017560.1
DBSOURCE    REFSEQ: accession NM_001017560.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Thyme SB, Pieper LM, Li EH, Pandey S, Wang Y, Morris NS, Sha C,
            Choi JW, Herrera KJ, Soucy ER, Zimmerman S, Randlett O, Greenwood
            J, McCarroll SA and Schier AF.
  TITLE     Phenotypic Landscape of Schizophrenia-Associated Genes Defines
            Candidates and Their Shared Functions
  JOURNAL   Cell 177 (2), 478-491 (2019)
   PUBMED   30929901
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Aksoy I, Utami KH, Winata CL, Hillmer AM, Rouam SL, Briault S,
            Davila S, Stanton LW and Cacheux V.
  TITLE     Personalized genome sequencing coupled with iPSC technology
            identifies GTDC1 as a gene involved in neurodevelopmental disorders
  JOURNAL   Hum Mol Genet 26 (2), 367-382 (2017)
   PUBMED   28365779
  REMARK    GeneRIF: we utilized a zebrafish model to demonstrate a role for
            GTDC1 in the development of the central nervous system. Our
            findings highlight the importance of combining sequencing
            technologies with the iPSC technology for NDDs modelling that could
            be applied for personalized medicine.
REFERENCE   3  (residues 1 to 433)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 433)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC092932.1.
            
            On Jul 6, 2005 this sequence version replaced XP_701787.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2168446, SAMEA2168447
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Danio rerio"
                     /strain="Singapore"
                     /db_xref="taxon:7955"
                     /chromosome="9"
                     /map="9"
     Protein         1..433
                     /product="glycosyltransferase-like domain-containing
                     protein 1"
                     /calculated_mol_wt=49604
     Region          2..164
                     /region_name="DUF3524"
                     /note="Domain of unknown function (DUF3524); pfam12038"
                     /db_xref="CDD:432280"
     Region          167..368
                     /region_name="Glycosyltransferase_GTB-type"
                     /note="glycosyltransferase family 1 and related proteins
                     with GTB topology; cd01635"
                     /db_xref="CDD:340816"
     Region          194..244
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q568B7.2)"
     CDS             1..433
                     /gene="gtdc1"
                     /gene_synonym="zgc:110568"
                     /coded_by="NM_001017560.1:61..1362"
                     /db_xref="GeneID:550132"
                     /db_xref="ZFIN:ZDB-GENE-050417-8"
ORIGIN      
        1 msvllleafy ggshkqlldl lkesvedcvs ftlpakkwhw rartsalyfm qavlanssyr
       61 vlftssvlnl aelvalrpdl ghlkkvlyfh enqlvypvrk sqerdfqygy nqilsclvad
      121 vvvfnssfnm esflssistf mktmpdhrpk dlerlirpkc hvlhfpirfp dvtrflpahk
      181 rlrhpvrcdd ihapaakshi qtsspssypd veppekmlnv agtnqshept svtphqetas
      241 plcghegekl rplhivwphr wehdkdpqlf fqtllklkdr qlsfevsvlg etftdvpdif
      301 seakeqlvdh iqhwgfmpsk edylkvlcqa dvvvstakhe ffgvamleav hcgcyplcpk
      361 alvypeifpa tylystpeql ckrlqefckr pqlarqhvvq vslssfswds lgdnfrsllk
      421 adsgrmftdk hla
//