GenomeNet

Database: RefSeq
Entry: NP_001020761
LinkDB: NP_001020761
Original site: NP_001020761 
LOCUS       NP_001020761             302 aa            linear   ROD 26-SEP-2019
DEFINITION  G protein-activated inward rectifier potassium channel 2 isoform
            Girk2C [Mus musculus].
ACCESSION   NP_001020761 XP_622705 XP_622771
VERSION     NP_001020761.1
DBSOURCE    REFSEQ: accession NM_001025590.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 302)
  AUTHORS   McCall NM, Marron Fernandez de Velasco E and Wickman K.
  TITLE     GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental
            Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine
  JOURNAL   J. Neurosci. 39 (19), 3600-3610 (2019)
   PUBMED   30837265
REFERENCE   2  (residues 1 to 302)
  AUTHORS   Liu Y, LoCaste CE, Liu W, Poltash ML, Russell DH and Laganowsky A.
  TITLE     Selective binding of a toxin and phosphatidylinositides to a
            mammalian potassium channel
  JOURNAL   Nat Commun 10 (1), 1352 (2019)
   PUBMED   30902995
  REMARK    GeneRIF: These results reveal selective small molecule binding and
            uncover a mechanism by which rotation of the cytoplasmic domain can
            modulate GIRK*phosphatidylinositide interactions.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 302)
  AUTHORS   Vaswani AR, Weykopf B, Hagemann C, Fried HU, Brustle O and Blaess
            S.
  TITLE     Correct setup of the substantia nigra requires Reelin-mediated
            fast, laterally-directed migration of dopaminergic neurons
  JOURNAL   Elife 8, e41623 (2019)
   PUBMED   30689541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 302)
  AUTHORS   Joshi K, Shen L, Cao F, Dong S, Jia Z, Cortez MA and Snead OC 3rd.
  TITLE     Kcnj6(GIRK2) trisomy is not sufficient for conferring the
            susceptibility to infantile spasms seen in the Ts65Dn mouse model
            of down syndrome
  JOURNAL   Epilepsy Res. 145, 82-88 (2018)
   PUBMED   29929098
  REMARK    GeneRIF: The results of this study indicated that Kcnj6 triploid
            mice show an increase in GIRK2 protein levels compared to WT mice
            in the cortex and thalamus.
REFERENCE   5  (residues 1 to 302)
  AUTHORS   Gonzalez JC, Epps SA, Markwardt SJ, Wadiche JI and
            Overstreet-Wadiche L.
  TITLE     Constitutive and Synaptic Activation of GIRK Channels
            Differentiates Mature and Newborn Dentate Granule Cells
  JOURNAL   J. Neurosci. 38 (29), 6513-6526 (2018)
   PUBMED   29915136
REFERENCE   6  (residues 1 to 302)
  AUTHORS   Takeda H, Yoshiki A, Nishikawa S, Nishikawa S, Kunisada T, Sakakura
            T, Amanuma H and Kusakabe M.
  TITLE     Expression of c-kit, a proto-oncogene of the murine W locus, in
            cerebella of normal and neurological mutant mice:
            immunohistochemical and in situ hybridization analysis
  JOURNAL   Differentiation 51 (2), 121-127 (1992)
   PUBMED   1282111
REFERENCE   7  (residues 1 to 302)
  AUTHORS   Crepel,F. and Mariani,J.
  TITLE     Multiple innervation of Purkinje cells by climbing fibers in the
            cerebellum of the Weaver Mutant Mouse
  JOURNAL   J. Neurobiol. 7 (6), 579-582 (1976)
   PUBMED   1003203
REFERENCE   8  (residues 1 to 302)
  AUTHORS   Mallet,J., Huchet,M., Pougeois,R. and Changeux,J.P.
  TITLE     Anatomical, physiological and biochemical studies on the cerebellum
            from mutant mice. III. Protein differences associated with the
            weaver, staggerer and nervous mutations
  JOURNAL   Brain Res. 103 (2), 291-312 (1976)
   PUBMED   1252920
REFERENCE   9  (residues 1 to 302)
  AUTHORS   Sotelo,C.
  TITLE     Anatomical, physiological and biochemical studies of the cerebellum
            from mutant mice. II. Morphological study of cerebellar cortical
            neurons and circuits in the weaver mouse
  JOURNAL   Brain Res. 94 (1), 19-44 (1975)
   PUBMED   1148865
REFERENCE   10 (residues 1 to 302)
  AUTHORS   Murad,S. and Kishimoto,Y.
  TITLE     Alpha hydroxylation of lignoceric acid to cerebronic acid during
            brain development. Diminished hydroxylase activity in
            myelin-deficient mouse mutants
  JOURNAL   J. Biol. Chem. 250 (15), 5841-5846 (1975)
   PUBMED   1150661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165248.2.
            On or before Jul 23, 2005 this sequence version replaced
            XP_622705.1, XP_622771.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..302
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 55.44 cM"
     Protein         1..302
                     /product="G protein-activated inward rectifier potassium
                     channel 2 isoform Girk2C"
                     /note="potassium inwardly-rectifying channel J6; g
                     protein-activated inward rectifier potassium channel 2;
                     GIRK-2; G-protein-coupled inward rectifier K+ channel 2-B;
                     inward rectifier K(+) channel Kir3.2; potassium channel,
                     inwardly rectifying subfamily J member 6;
                     G-protein-coupled inward rectifier K+ channel 2-1;
                     G-protein-coupled inward rectifier K+ channel 2-A;
                     G-protein-coupled inward rectifier K+ channel 2-C"
                     /calculated_mol_wt=34662
     Region          41..>302
                     /region_name="Ion_trans_2"
                     /note="Ion channel; cl21560"
                     /db_xref="CDD:328796"
     CDS             1..302
                     /gene="Kcnj6"
                     /gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
                     wv"
                     /coded_by="NM_001025590.2:258..1166"
                     /note="isoform Girk2C is encoded by transcript variant
                     Girk2C"
                     /db_xref="CCDS:CCDS49921.1"
                     /db_xref="GeneID:16522"
                     /db_xref="MGI:MGI:104781"
ORIGIN      
        1 mdqdvespva ihqpklpkqa rddlprhisr drtkrkiqry vrkdgkcnvh hgnvretyry
       61 ltdifttlvd lkwrfnllif vmvytvtwlf fgmiwwliay irgdmdhied pswtpcvtnl
      121 ngfvsaflfs ietettigyg yrvitdkcpe giillliqsv lgsivnafmv gcmfvkisqp
      181 kkraetlvfs thavismrdg klclmfrvgd lrnshiveas iraklikskq tsegefipln
      241 qtdinvgyyt gddrlflvsp liisheinqq spfweiskaq lpkeeleivv ilegmveatg
      301 qf
//
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