LOCUS NP_001020761 302 aa linear ROD 26-SEP-2019
DEFINITION G protein-activated inward rectifier potassium channel 2 isoform
Girk2C [Mus musculus].
ACCESSION NP_001020761 XP_622705 XP_622771
VERSION NP_001020761.1
DBSOURCE REFSEQ: accession NM_001025590.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 302)
AUTHORS McCall NM, Marron Fernandez de Velasco E and Wickman K.
TITLE GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental
Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine
JOURNAL J. Neurosci. 39 (19), 3600-3610 (2019)
PUBMED 30837265
REFERENCE 2 (residues 1 to 302)
AUTHORS Liu Y, LoCaste CE, Liu W, Poltash ML, Russell DH and Laganowsky A.
TITLE Selective binding of a toxin and phosphatidylinositides to a
mammalian potassium channel
JOURNAL Nat Commun 10 (1), 1352 (2019)
PUBMED 30902995
REMARK GeneRIF: These results reveal selective small molecule binding and
uncover a mechanism by which rotation of the cytoplasmic domain can
modulate GIRK*phosphatidylinositide interactions.
Publication Status: Online-Only
REFERENCE 3 (residues 1 to 302)
AUTHORS Vaswani AR, Weykopf B, Hagemann C, Fried HU, Brustle O and Blaess
S.
TITLE Correct setup of the substantia nigra requires Reelin-mediated
fast, laterally-directed migration of dopaminergic neurons
JOURNAL Elife 8, e41623 (2019)
PUBMED 30689541
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 302)
AUTHORS Joshi K, Shen L, Cao F, Dong S, Jia Z, Cortez MA and Snead OC 3rd.
TITLE Kcnj6(GIRK2) trisomy is not sufficient for conferring the
susceptibility to infantile spasms seen in the Ts65Dn mouse model
of down syndrome
JOURNAL Epilepsy Res. 145, 82-88 (2018)
PUBMED 29929098
REMARK GeneRIF: The results of this study indicated that Kcnj6 triploid
mice show an increase in GIRK2 protein levels compared to WT mice
in the cortex and thalamus.
REFERENCE 5 (residues 1 to 302)
AUTHORS Gonzalez JC, Epps SA, Markwardt SJ, Wadiche JI and
Overstreet-Wadiche L.
TITLE Constitutive and Synaptic Activation of GIRK Channels
Differentiates Mature and Newborn Dentate Granule Cells
JOURNAL J. Neurosci. 38 (29), 6513-6526 (2018)
PUBMED 29915136
REFERENCE 6 (residues 1 to 302)
AUTHORS Takeda H, Yoshiki A, Nishikawa S, Nishikawa S, Kunisada T, Sakakura
T, Amanuma H and Kusakabe M.
TITLE Expression of c-kit, a proto-oncogene of the murine W locus, in
cerebella of normal and neurological mutant mice:
immunohistochemical and in situ hybridization analysis
JOURNAL Differentiation 51 (2), 121-127 (1992)
PUBMED 1282111
REFERENCE 7 (residues 1 to 302)
AUTHORS Crepel,F. and Mariani,J.
TITLE Multiple innervation of Purkinje cells by climbing fibers in the
cerebellum of the Weaver Mutant Mouse
JOURNAL J. Neurobiol. 7 (6), 579-582 (1976)
PUBMED 1003203
REFERENCE 8 (residues 1 to 302)
AUTHORS Mallet,J., Huchet,M., Pougeois,R. and Changeux,J.P.
TITLE Anatomical, physiological and biochemical studies on the cerebellum
from mutant mice. III. Protein differences associated with the
weaver, staggerer and nervous mutations
JOURNAL Brain Res. 103 (2), 291-312 (1976)
PUBMED 1252920
REFERENCE 9 (residues 1 to 302)
AUTHORS Sotelo,C.
TITLE Anatomical, physiological and biochemical studies of the cerebellum
from mutant mice. II. Morphological study of cerebellar cortical
neurons and circuits in the weaver mouse
JOURNAL Brain Res. 94 (1), 19-44 (1975)
PUBMED 1148865
REFERENCE 10 (residues 1 to 302)
AUTHORS Murad,S. and Kishimoto,Y.
TITLE Alpha hydroxylation of lignoceric acid to cerebronic acid during
brain development. Diminished hydroxylase activity in
myelin-deficient mouse mutants
JOURNAL J. Biol. Chem. 250 (15), 5841-5846 (1975)
PUBMED 1150661
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC165248.2.
On or before Jul 23, 2005 this sequence version replaced
XP_622705.1, XP_622771.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U51126.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849384 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..302
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="16"
/map="16 55.44 cM"
Protein 1..302
/product="G protein-activated inward rectifier potassium
channel 2 isoform Girk2C"
/note="potassium inwardly-rectifying channel J6; g
protein-activated inward rectifier potassium channel 2;
GIRK-2; G-protein-coupled inward rectifier K+ channel 2-B;
inward rectifier K(+) channel Kir3.2; potassium channel,
inwardly rectifying subfamily J member 6;
G-protein-coupled inward rectifier K+ channel 2-1;
G-protein-coupled inward rectifier K+ channel 2-A;
G-protein-coupled inward rectifier K+ channel 2-C"
/calculated_mol_wt=34662
Region 41..>302
/region_name="Ion_trans_2"
/note="Ion channel; cl21560"
/db_xref="CDD:328796"
CDS 1..302
/gene="Kcnj6"
/gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
wv"
/coded_by="NM_001025590.2:258..1166"
/note="isoform Girk2C is encoded by transcript variant
Girk2C"
/db_xref="CCDS:CCDS49921.1"
/db_xref="GeneID:16522"
/db_xref="MGI:MGI:104781"
ORIGIN
1 mdqdvespva ihqpklpkqa rddlprhisr drtkrkiqry vrkdgkcnvh hgnvretyry
61 ltdifttlvd lkwrfnllif vmvytvtwlf fgmiwwliay irgdmdhied pswtpcvtnl
121 ngfvsaflfs ietettigyg yrvitdkcpe giillliqsv lgsivnafmv gcmfvkisqp
181 kkraetlvfs thavismrdg klclmfrvgd lrnshiveas iraklikskq tsegefipln
241 qtdinvgyyt gddrlflvsp liisheinqq spfweiskaq lpkeeleivv ilegmveatg
301 qf
//
