LOCUS NP_001020761 302 aa linear ROD 27-APR-2025
DEFINITION G protein-activated inward rectifier potassium channel 2 isoform
Girk2C [Mus musculus].
ACCESSION NP_001020761 XP_622705 XP_622771
VERSION NP_001020761.1
DBSOURCE REFSEQ: accession NM_001025590.2
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 302)
AUTHORS Luo,H., Marron Fernandez de Velasco,E., Gansemer,B., Frederick,M.,
Aguado,C., Lujan,R., Thayer,S.A. and Wickman,K.
TITLE Amyloid-beta oligomers trigger sex-dependent inhibition of GIRK
channel activity in hippocampal neurons in mice
JOURNAL Sci Signal 17 (856), eado4132 (2024)
PUBMED 39353038
REFERENCE 2 (residues 1 to 302)
AUTHORS Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
Jackson,S.P. and Balmus,G.
CONSRTM Sanger Mouse Genetics Project
TITLE Genetic determinants of micronucleus formation in vivo
JOURNAL Nature 627 (8002), 130-136 (2024)
PUBMED 38355793
REFERENCE 3 (residues 1 to 302)
AUTHORS Lana-Elola,E., Aoidi,R., Llorian,M., Gibbins,D.,
Buechsenschuetz,C., Bussi,C., Flynn,H., Gilmore,T.,
Watson-Scales,S., Haugsten Hansen,M., Hayward,D., Song,O.R.,
Brault,V., Herault,Y., Deau,E., Meijer,L., Snijders,A.P.,
Gutierrez,M.G., Fisher,E.M.C. and Tybulewicz,V.L.J.
TITLE Increased dosage of DYRK1A leads to congenital heart defects in a
mouse model of Down syndrome
JOURNAL Sci Transl Med 16 (731), eadd6883 (2024)
PUBMED 38266108
REFERENCE 4 (residues 1 to 302)
AUTHORS Oh,Y., Yoo,E.S., Ju,S.H., Kim,E., Lee,S., Kim,S., Wickman,K. and
Sohn,J.W.
TITLE GIRK2 potassium channels expressed by the AgRP neurons decrease
adiposity and body weight in mice
JOURNAL PLoS Biol 21 (8), e3002252 (2023)
PUBMED 37594983
REMARK GeneRIF: GIRK2 potassium channels expressed by the AgRP neurons
decrease adiposity and body weight in mice.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 302)
AUTHORS Van Heesbeen,H.J., Von Oerthel,L., De Vries,P.M., Wagemans,C.M.R.J.
and Smidt,M.P.
TITLE Neuronal Dot1l Activity Acts as a Mitochondrial Gene-Repressor
Associated with Human Brain Aging via H3K79 Hypermethylation
JOURNAL Int J Mol Sci 24 (2), 1387 (2023)
PUBMED 36674903
REMARK Publication Status: Online-Only
REFERENCE 6 (residues 1 to 302)
AUTHORS Takeda,H., Yoshiki,A., Nishikawa,S., Nishikawa,S., Kunisada,T.,
Sakakura,T., Amanuma,H. and Kusakabe,M.
TITLE Expression of c-kit, a proto-oncogene of the murine W locus, in
cerebella of normal and neurological mutant mice:
immunohistochemical and in situ hybridization analysis
JOURNAL Differentiation 51 (2), 121-127 (1992)
PUBMED 1282111
REFERENCE 7 (residues 1 to 302)
AUTHORS Crepel,F. and Mariani,J.
TITLE Multiple innervation of Purkinje cells by climbing fibers in the
cerebellum of the Weaver Mutant Mouse
JOURNAL J Neurobiol 7 (6), 579-582 (1976)
PUBMED 1003203
REFERENCE 8 (residues 1 to 302)
AUTHORS Mallet,J., Huchet,M., Pougeois,R. and Changeux,J.P.
TITLE Anatomical, physiological and biochemical studies on the cerebellum
from mutant mice. III. Protein differences associated with the
weaver, staggerer and nervous mutations
JOURNAL Brain Res 103 (2), 291-312 (1976)
PUBMED 1252920
REFERENCE 9 (residues 1 to 302)
AUTHORS Sotelo,C.
TITLE Anatomical, physiological and biochemical studies of the cerebellum
from mutant mice. II. Morphological study of cerebellar cortical
neurons and circuits in the weaver mouse
JOURNAL Brain Res 94 (1), 19-44 (1975)
PUBMED 1148865
REFERENCE 10 (residues 1 to 302)
AUTHORS Murad,S. and Kishimoto,Y.
TITLE Alpha hydroxylation of lignoceric acid to cerebronic acid during
brain development. Diminished hydroxylase activity in
myelin-deficient mouse mutants
JOURNAL J Biol Chem 250 (15), 5841-5846 (1975)
PUBMED 1150661
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC165248.2.
On or before Jul 23, 2005 this sequence version replaced
XP_622705.1, XP_622771.1.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: U51126.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849384 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..302
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="16"
/map="16 55.44 cM"
Protein 1..302
/product="G protein-activated inward rectifier potassium
channel 2 isoform Girk2C"
/note="potassium inwardly-rectifying channel J6; g
protein-activated inward rectifier potassium channel 2;
GIRK-2; G-protein-coupled inward rectifier K+ channel 2-B;
inward rectifier K(+) channel Kir3.2; potassium channel,
inwardly rectifying subfamily J member 6;
G-protein-coupled inward rectifier K+ channel 2-1;
G-protein-coupled inward rectifier K+ channel 2-A;
G-protein-coupled inward rectifier K+ channel 2-C"
/calculated_mol_wt=34662
Region 41..180
/region_name="IRK"
/note="Inward rectifier potassium channel transmembrane
domain; pfam01007"
/db_xref="CDD:460023"
Region 187..>302
/region_name="IRK_C"
/note="Inward rectifier potassium channel C-terminal
domain; pfam17655"
/db_xref="CDD:465439"
CDS 1..302
/gene="Kcnj6"
/gene_synonym="BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver;
wv"
/coded_by="NM_001025590.2:258..1166"
/note="isoform Girk2C is encoded by transcript variant
Girk2C"
/db_xref="CCDS:CCDS49921.1"
/db_xref="GeneID:16522"
/db_xref="MGI:MGI:104781"
ORIGIN
1 mdqdvespva ihqpklpkqa rddlprhisr drtkrkiqry vrkdgkcnvh hgnvretyry
61 ltdifttlvd lkwrfnllif vmvytvtwlf fgmiwwliay irgdmdhied pswtpcvtnl
121 ngfvsaflfs ietettigyg yrvitdkcpe giillliqsv lgsivnafmv gcmfvkisqp
181 kkraetlvfs thavismrdg klclmfrvgd lrnshiveas iraklikskq tsegefipln
241 qtdinvgyyt gddrlflvsp liisheinqq spfweiskaq lpkeeleivv ilegmveatg
301 qf
//
