LOCUS       NP_001072815             336 aa            linear   VRT 05-AUG-2022
DEFINITION  N-lysine methyltransferase KMT5A [Xenopus tropicalis].
ACCESSION   NP_001072815
VERSION     NP_001072815.1
DBSOURCE    REFSEQ: accession NM_001079347.1
KEYWORDS    RefSeq.
SOURCE      Xenopus tropicalis (tropical clawed frog)
  ORGANISM  Xenopus tropicalis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Silurana.
REFERENCE   1  (residues 1 to 336)
  AUTHORS   Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
            Richardson P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev Dyn 225 (4), 384-391 (2002)
   PUBMED   12454917
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC121601.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC121601.1, CX439170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09788948, SAMN09788949
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..336
                     /organism="Xenopus tropicalis"
                     /db_xref="taxon:8364"
                     /chromosome="1"
                     /map="1"
     Protein         1..336
                     /product="N-lysine methyltransferase KMT5A"
                     /EC_number="2.1.1.361"
                     /note="SET domain-containing protein 8; histone-lysine
                     N-methyltransferase SETD8; lysine (K)-specific
                     methyltransferase 5A; SET domain containing (lysine
                     methyltransferase) 8; N-lysine methyltransferase SETD8;
                     lysine-specific methylase 5A; histone-lysine
                     N-methyltransferase KMT5A"
                     /calculated_mol_wt=38106
     Region          1..112
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q0V9E9.1)"
     Region          184..323
                     /region_name="SET_SETD8"
                     /note="SET domain found in SET domain-containing protein 8
                     (SETD8) and similar proteins; cd10528"
                     /db_xref="CDD:380926"
     Site            order(211..213,229,254..258,279..283,320)
                     /site_type="active"
                     /db_xref="CDD:380926"
     Site            order(211..213,254..255,279..283,320)
                     /site_type="other"
                     /note="SAM binding site"
                     /db_xref="CDD:380926"
     Site            order(229,243,246..247,253..254,256..259,291,302,318,
                     320..323)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:380926"
     CDS             1..336
                     /gene="kmt5a"
                     /gene_synonym="pr-set7; set07; set8; setd8"
                     /coded_by="NM_001079347.1:145..1155"
                     /db_xref="GeneID:780276"
                     /db_xref="Xenbase:XB-GENE-489177"
ORIGIN      
        1 mgrgkkmskp gdgrsgdvpd tgrtggtnen hpkingevah lgqpkiysfm sptkspsarp
       61 plqeensvah heskcpgkpl tetrkkaeve kkrissgtel svkpseqret ecnsigefld
      121 pkqeqtdvrr nialppadkl nhqkmvkdkp lrrkaqrkks pnrkltdyyp vrrscrkskt
      181 eleseekkri deliqtgkee gmkmdmitgk grgviatrdf qrgefvveyh gdlieitdak
      241 rreatyaqds ntgcymyyfq ylnktycida tretgrlgrl inhsksgnch tklhninnvp
      301 hlilvasrdi nvgeellydy gdrrksslea hpwlkn
//