LOCUS NP_001074663 1018 aa linear ROD 26-SEP-2023
DEFINITION potassium voltage-gated channel subfamily H member 4 [Mus
musculus].
ACCESSION NP_001074663 XP_354643
VERSION NP_001074663.1
DBSOURCE REFSEQ: accession NM_001081194.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 1018)
AUTHORS Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
TITLE Mouse screen reveals multiple new genes underlying mouse and human
hearing loss
JOURNAL PLoS Biol 17 (4), e3000194 (2019)
PUBMED 30973865
REMARK Publication Status: Online-Only
REFERENCE 2 (residues 1 to 1018)
AUTHORS Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
SA.
CONSRTM International Mouse Phenotyping Consortium; Jackson Laboratory;
Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
(ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
Center
TITLE High-throughput discovery of novel developmental phenotypes
JOURNAL Nature 537 (7621), 508-514 (2016)
PUBMED 27626380
REMARK Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE 3 (residues 1 to 1018)
AUTHORS Tuck E, Estabel J, Oellrich A, Maguire AK, Adissu HA, Souter L,
Siragher E, Lillistone C, Green AL, Wardle-Jones H, Carragher DM,
Karp NA, Smedley D, Adams NC, Bussell JN, Adams DJ, Ramirez-Solis
R, Steel KP, Galli A and White JK.
CONSRTM Sanger Institute Mouse Genetics Project
TITLE A gene expression resource generated by genome-wide lacZ profiling
in the mouse
JOURNAL Dis Model Mech 8 (11), 1467-1478 (2015)
PUBMED 26398943
REFERENCE 4 (residues 1 to 1018)
AUTHORS Cui Y, Li M, Walton KD, Sun K, Hanover JA, Furth PA and
Hennighausen L.
TITLE The Stat3/5 locus encodes novel endoplasmic reticulum and
helicase-like proteins that are preferentially expressed in normal
and neoplastic mammary tissue
JOURNAL Genomics 78 (3), 129-134 (2001)
PUBMED 11735219
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC150990.1 and AL591469.9.
On Feb 6, 2007 this sequence version replaced XP_354643.4.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
CDS exon combination :: BC150990.1, SRR7345562.1684267.1
[ECO:0000331]
RNAseq introns :: mixed sample support SAMN00849374,
SAMN00849375 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
NMD candidate :: translation inferred from conservation
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..1018
/organism="Mus musculus"
/db_xref="taxon:10090"
/chromosome="11"
/map="11 63.57 cM"
Protein 1..1018
/product="potassium voltage-gated channel subfamily H
member 4"
/calculated_mol_wt=111350
Region 41..>134
/region_name="PRK13557"
/note="histidine kinase; Provisional"
/db_xref="CDD:237425"
Region 177..>620
/region_name="PLN03192"
/note="Voltage-dependent potassium channel; Provisional"
/db_xref="CDD:215625"
Region 578..667
/region_name="cNMP_binding"
/note="Cyclic nucleotide-binding domain; pfam00027"
/db_xref="CDD:425428"
Region <712..1003
/region_name="PHA03247"
/note="large tegument protein UL36; Provisional"
/db_xref="CDD:223021"
CDS 1..1018
/gene="Kcnh4"
/gene_synonym="BEC2"
/coded_by="NM_001081194.2:174..3230"
/db_xref="CCDS:CCDS36334.1"
/db_xref="GeneID:380728"
/db_xref="MGI:MGI:2156184"
ORIGIN
1 mpvmkgllap qntfldtiat rfdgthsnfl lanaqgprgf pivycsdgfc eltgygrtev
61 mqktcscrfl ygpetsepal qrlqkalegh qehrteicfy rkdgsafwcl ldmmpiknem
121 gevvlflfsf kdisqsggpg lgspgihgdn nhenslgrrg tssrlrstkr qnrtvlhrlt
181 ghfgrrgqss vkansnlfep kpsvpeykva svggsrclll hysipkavwd glillatfyv
241 avtvpynvcf agdddtpits rhtlvsdiav emlfildiil nfrttyvsqs gqvisaprsi
301 glhylatwff vdliaalpfd llyvfnitvt slvhllktvr llrllrllqk lerysqcsav
361 vltllmsvfa llahwmacvw yvigrremea ndpllwdigw lhelgkrlee pyvngsaggp
421 srrsayiaal yftlssltsv gfgnvcantd aekifsictm ligalmhavv fgnvtaiiqr
481 mysrrslyhs rmkdlkdfir vhrlprplkq rmleyfqttw avnsgidane llrdfpdelr
541 adiamhlnre ilqlplfgaa srgclralsl hiktsfcapg eyllrrgdal qahyyvcsgs
601 levlrdnmvl ailgkgdlig adipelgqep gsgagpscvl ktsadvkalt ycglqqlssr
661 glaevlrlyp eyaaafragl prdltfnlrq gsennglgrf srsprlsqar sdtlgsssdk
721 tlpsiteteg gtepgagskp rrphllpnls parprgslvs llgeelppfs alvsspslsp
781 tpspalagrg qspsphgppr gsaawkppql lipplgtfgp pdlsprivdg iedssntaea
841 ptfrfskrpe ptrtrsqapp sgprlsrela teaaeevkek vcrlnqeisr lnqevsqlsr
901 elrqvmgllq arlgppshta gpawlpdlpc phqrlpcisp hmsgpppglq nttlavvhcp
961 asvgtveiga tpselrpsti ppypsepdpl gpspapeapp ltpsllkhsf qsgsdtfh
//
