GenomeNet

Database: RefSeq
Entry: NP_001075492
LinkDB: NP_001075492
Original site: NP_001075492 
LOCUS       NP_001075492             735 aa            linear   MAM 09-DEC-2018
DEFINITION  glycogen [starch] synthase, muscle [Oryctolagus cuniculus].
ACCESSION   NP_001075492
VERSION     NP_001075492.1
DBSOURCE    REFSEQ: accession NM_001082023.1
KEYWORDS    RefSeq.
SOURCE      Oryctolagus cuniculus (rabbit)
  ORGANISM  Oryctolagus cuniculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha;
            Leporidae; Oryctolagus.
REFERENCE   1  (residues 1 to 735)
  AUTHORS   Flotow H, Graves PR, Wang AQ, Fiol CJ, Roeske RW and Roach PJ.
  TITLE     Phosphate groups as substrate determinants for casein kinase I
            action
  JOURNAL   J. Biol. Chem. 265 (24), 14264-14269 (1990)
   PUBMED   2117608
REFERENCE   2  (residues 1 to 735)
  AUTHORS   Zhang WM, Browner MF, Fletterick RJ, DePaoli-Roach AA and Roach PJ.
  TITLE     Primary structure of rabbit skeletal muscle glycogen synthase
            deduced from cDNA clones
  JOURNAL   FASEB J. 3 (13), 2532-2536 (1989)
   PUBMED   2509275
REFERENCE   3  (residues 1 to 735)
  AUTHORS   Mahrenholz AM, Votaw P, Roach PJ, Depaoli-Roach AA, Zioncheck TF,
            Harrison ML and Geahlen RL.
  TITLE     Phosphorylation of glycogen synthase by a bovine thymus
            protein-tyrosine kinase, p40
  JOURNAL   Biochem. Biophys. Res. Commun. 155 (1), 52-58 (1988)
   PUBMED   3137939
REFERENCE   4  (residues 1 to 735)
  AUTHORS   Poulter L, Ang SG, Gibson BW, Williams DH, Holmes CF, Caudwell FB,
            Pitcher J and Cohen P.
  TITLE     Analysis of the in vivo phosphorylation state of rabbit skeletal
            muscle glycogen synthase by fast-atom-bombardment mass spectrometry
  JOURNAL   Eur. J. Biochem. 175 (3), 497-510 (1988)
   PUBMED   2842154
REFERENCE   5  (residues 1 to 735)
  AUTHORS   Mahrenholz AM, Wang YH and Roach PJ.
  TITLE     Catalytic site of rabbit glycogen synthase isozymes. Identification
            of an active site lysine close to the amino terminus of the subunit
  JOURNAL   J. Biol. Chem. 263 (22), 10561-10567 (1988)
   PUBMED   3134350
REFERENCE   6  (residues 1 to 735)
  AUTHORS   Cohen,P., Holmes,C.F., Poulter,L., Gibson,B. and Williams,D.H.
  TITLE     Identification of the C-terminus of rabbit skeletal muscle glycogen
            synthase
  JOURNAL   Biochem. Biophys. Res. Commun. 137 (1), 542-545 (1986)
   PUBMED   3087361
REFERENCE   7  (residues 1 to 735)
  AUTHORS   Kuret,J., Woodgett,J.R. and Cohen,P.
  TITLE     Multisite phosphorylation of glycogen synthase from rabbit skeletal
            muscle. Identification of the sites phosphorylated by casein
            kinase-I
  JOURNAL   Eur. J. Biochem. 151 (1), 39-48 (1985)
   PUBMED   3928373
REFERENCE   8  (residues 1 to 735)
  AUTHORS   Rylatt,D.B., Aitken,A., Bilham,T., Condon,G.D., Embi,N. and
            Cohen,P.
  TITLE     Glycogen synthase from rabbit skeletal muscle. Amino acid sequence
            at the sites phosphorylated by glycogen synthase kinase-3, and
            extension of the N-terminal sequence containing the site
            phosphorylated by phosphorylase kinase
  JOURNAL   Eur. J. Biochem. 107 (2), 529-537 (1980)
   PUBMED   6772446
REFERENCE   9  (residues 1 to 735)
  AUTHORS   Huang,T.S. and Krebs,E.G.
  TITLE     Effect of proteases on the structure and activity of rabbit
            skeletal muscle glycogen synthetase
  JOURNAL   FEBS Lett. 98 (1), 66-70 (1979)
   PUBMED   107043
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF017114.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00013637, SAMN00013641
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Oryctolagus cuniculus"
                     /db_xref="taxon:9986"
     Protein         1..735
                     /product="glycogen [starch] synthase, muscle"
                     /EC_number="2.4.1.11"
                     /function="catalyzes the formation of alpha 1,4-glycosidic
                     linkages in glycogen"
                     /note="glycogen synthase 1 (muscle)"
                     /calculated_mol_wt=83471
     Site            8
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by AMPK and PKA.
                     {ECO:0000269|PubMed:2842154, ECO:0000269|PubMed:6772446};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     Site            11
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000269|PubMed:2842154,
                     ECO:0000269|PubMed:3928373}; propagated from
                     UniProtKB/Swiss-Prot (P13834.4)"
     Region          26..615
                     /region_name="GT1_Glycogen_synthase_GSY2_like"
                     /note="Glycogen synthase, which is most closely related to
                     the GT1 family of glycosyltransferases, catalyzes the
                     transfer of a glucose molecule from UDP-glucose to a
                     terminal branch of a glycogen molecule, a rate-limit step
                     of glycogen biosynthesis. GSY2, the...; cd03793"
                     /db_xref="CDD:99967"
     Region          31..663
                     /region_name="Glycogen_syn"
                     /note="Glycogen synthase; pfam05693"
                     /db_xref="CDD:283373"
     Site            412
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P13807};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     Site            641
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by DYRK2, GSK3-alpha, GSK3-beta and
                     PASK. {ECO:0000269|PubMed:14593110,
                     ECO:0000269|PubMed:2820993, ECO:0000269|PubMed:2842154,
                     ECO:0000269|PubMed:6772446}; propagated from
                     UniProtKB/Swiss-Prot (P13834.4)"
     Site            645
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by GSK3-alpha and GSK3-beta.
                     {ECO:0000269|PubMed:2820993, ECO:0000269|PubMed:2842154,
                     ECO:0000269|PubMed:6772446}; propagated from
                     UniProtKB/Swiss-Prot (P13834.4)"
     Site            649
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by GSK3-alpha and GSK3-beta.
                     {ECO:0000269|PubMed:2820993, ECO:0000269|PubMed:2842154,
                     ECO:0000269|PubMed:6772446}; propagated from
                     UniProtKB/Swiss-Prot (P13834.4)"
     Site            652
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:A2RRU1};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     Site            653
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by GSK3-alpha and GSK3-beta.
                     {ECO:0000269|PubMed:2820993, ECO:0000269|PubMed:2842154};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     Site            657
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by CK2. {ECO:0000269|PubMed:2820993,
                     ECO:0000269|PubMed:2842154}; propagated from
                     UniProtKB/Swiss-Prot (P13834.4)"
     Site            698
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000269|PubMed:2842154,
                     ECO:0000269|PubMed:3928373}; propagated from
                     UniProtKB/Swiss-Prot (P13834.4)"
     Site            700
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000250|UniProtKB:P13807};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     Site            709
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:Q9Z1E4};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     Site            711
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P13807};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     Site            719
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine. {ECO:0000250|UniProtKB:Q9Z1E4};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     Site            725
                     /site_type="other"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000250|UniProtKB:P13807};
                     propagated from UniProtKB/Swiss-Prot (P13834.4)"
     CDS             1..735
                     /gene="GYS1"
                     /coded_by="NM_001082023.1:124..2331"
                     /db_xref="GeneID:100008660"
ORIGIN      
        1 mplsrtlsvs slpgledwed efdlensvlf evawevankv ggiytvlqtk akvtgdewgd
       61 nyflvgpyte qgvrtqvell epptpalkrt ldsmnskgck vyfgrwlieg gplvvlldvg
      121 asawalerwk gelwdtcnig vpwydreand avlfgflttw flgeflaqne ekphvvahfh
      181 ewlagiglcl crarrlpvat iftthatllg rylcagavdf ynnlenfnvd keagerqiyh
      241 rycmeraaah cahvfttvsq itaieaqhll krkpdivtpn glnvkkfsam hefqnlhaqs
      301 kariqefvrg hfyghldfnl dktlyffiag ryefsnkgad vflealarln yllrvngseq
      361 tvvaffimpa rtnnfnvetl kgqavrkqlw dtantvkekf grklyesllv gslpdmnkml
      421 dkedftmmkr aifatqrqsf ppvcthnmld dssdpiltti rriglfnssa drvkvifhpe
      481 flsstspllp vdyeefvrgc hlgvfpsyye pwgytpaect vmgipsistn lsgfgcfmee
      541 hiadpsaygi yildrrfrsl ddscsqltsf lysfcqqsrr qriiqrnrte rlsdlldwky
      601 lgryymsarh malakafpdh ftyepheada tqgyryprpa svppspslsr hssphqsede
      661 eeprdglpee dgerydedee aakdrrnira pewprrasct sssggskrsn svdtsslstp
      721 seplspassl geern
//
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