LOCUS NP_001075815 557 aa linear MAM 12-FEB-2023
DEFINITION complement component C9 precursor [Oryctolagus cuniculus].
ACCESSION NP_001075815
VERSION NP_001075815.1
DBSOURCE REFSEQ: accession NM_001082346.1
KEYWORDS RefSeq.
SOURCE Oryctolagus cuniculus (rabbit)
ORGANISM Oryctolagus cuniculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha;
Leporidae; Oryctolagus.
REFERENCE 1 (residues 1 to 557)
AUTHORS Husler T, Lockert DH, Kaufman KM, Sodetz JM and Sims PJ.
TITLE Chimeras of human complement C9 reveal the site recognized by
complement regulatory protein CD59
JOURNAL J Biol Chem 270 (8), 3483-3486 (1995)
PUBMED 7533152
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from U20055.1.
##Evidence-Data-START##
Transcript exon combination :: U20055.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA5760402, SAMEA5760429
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..557
/organism="Oryctolagus cuniculus"
/db_xref="taxon:9986"
/chromosome="11"
/map="11"
Protein 1..557
/product="complement component C9 precursor"
/note="complement component C9"
/calculated_mol_wt=60543
sig_peptide 1..21
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2138
mat_peptide 22..557
/product="complement component C9"
/experiment="experimental evidence, no additional details
recorded"
/calculated_mol_wt=60543
Region 43..88
/region_name="TSP1_spondin"
/note="Spondin-like TSP1 domain; pfam19028"
/db_xref="CDD:436909"
Region 100..135
/region_name="Ldl_recept_a"
/note="Low-density lipoprotein receptor domain class A;
pfam00057"
/db_xref="CDD:395011"
Site order(106,114,125..126)
/site_type="active"
/note="putative binding surface [active]"
/db_xref="CDD:238060"
Site order(118,121,125,131..132)
/site_type="other"
/note="calcium-binding site [ion binding]"
/db_xref="CDD:238060"
Site 128..132
/site_type="other"
/note="D-X-S-D-E motif"
/db_xref="CDD:238060"
Site 261
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P48747.1)"
Site 282
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P48747.1)"
Region 299..513
/region_name="MACPF"
/note="membrane-attack complex / perforin; smart00457"
/db_xref="CDD:214671"
Site 319..335
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P48747.1)"
Site 340..359
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P48747.1)"
Site 424
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (P48747.1)"
CDS 1..557
/gene="C9"
/coded_by="NM_001082346.1:13..1686"
/db_xref="GeneID:100009197"
ORIGIN
1 maashsfafv vcvleigalt agptpsyvhe piqrsdplqp idcrmspwse wshcdpclrq
61 mfrsrsievf gqfhgkscvd algdrracip teacedaeed cekdefhcgt grcikrrllc
121 ngdndcgdfs deddcetepr ltcrnrevqe selartagyg inilgmdpla tpfdneyyhg
181 lcdrvwdgnt lthyrkpwnv avlayetkid knfrteyyee qmqafksiie eetsnfnanl
241 alkftpteak askaeeaspk nkslddndkg fsskfqfsys knetyqlfls yssqkekmfl
301 lvkgiiqlgr fvmknrgvml tntflddiks lpttyekgey fafletygth ysssgslggr
361 yeliyvldka smkekgieln dikkclgfdl dlslnipgks aglsltgqan knnclksghg
421 navnitranl iddvislirg gtqkfafelk eklltkakmv dvtdfinwas slsdapvlin
481 qklspiynli pvkikdahqk rqnlergied yinefstkkc spcqnggtal lmdgqclctc
541 pfmfegiace iskrkla
//
