LOCUS       NP_001081207             527 aa            linear   VRT 24-JUN-2020
DEFINITION  bone morphogenetic protein receptor type 1A L homeolog precursor
            [Xenopus laevis].
ACCESSION   NP_001081207 NP_001081208
VERSION     NP_001081207.1
DBSOURCE    REFSEQ: accession NM_001087738.1
KEYWORDS    RefSeq.
SOURCE      Xenopus laevis (African clawed frog)
  ORGANISM  Xenopus laevis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae;
            Xenopus; Xenopus.
REFERENCE   1  (residues 1 to 527)
  AUTHORS   Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW and
            Richardson P.
  TITLE     Genetic and genomic tools for Xenopus research: The NIH Xenopus
            initiative
  JOURNAL   Dev. Dyn. 225 (4), 384-391 (2002)
   PUBMED   12454917
REFERENCE   2  (residues 1 to 527)
  AUTHORS   Graff JM, Thies RS, Song JJ, Celeste AJ and Melton DA.
  TITLE     Studies with a Xenopus BMP receptor suggest that ventral
            mesoderm-inducing signals override dorsal signals in vivo
  JOURNAL   Cell 79 (1), 169-179 (1994)
   PUBMED   7522972
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D32066.1.
            
            On Jul 25, 2007 this sequence version replaced NP_001081208.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D32066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00012418, SAMD00012419
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Xenopus laevis"
                     /db_xref="taxon:8355"
                     /chromosome="7L"
     Protein         1..527
                     /product="bone morphogenetic protein receptor type 1A L
                     homeolog precursor"
                     /note="BMP receptor"
                     /calculated_mol_wt=57416
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2389
     Region          57..132
                     /region_name="Activin_recp"
                     /note="Activin types I and II receptor domain; pfam01064"
                     /db_xref="CDD:426025"
     Region          233..519
                     /region_name="STKc_BMPR1a"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     Bone Morphogenetic Protein Type IA Receptor; cd14220"
                     /db_xref="CDD:271122"
     Site            order(235..239,243,254,256,284,304..307,311,313,357,359,
                     361..362,364,375,378,398..401)
                     /site_type="active"
                     /db_xref="CDD:271122"
     Site            order(235..241,243,254,256,304..305,307,311,361..362,364,
                     375)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:271122"
     Site            order(239,311,313,357,359,361,378,398..401)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:271122"
     Site            order(266..267,270..271,274,289,291)
                     /site_type="other"
                     /note="FKBP12 binding site [polypeptide binding]"
                     /db_xref="CDD:271122"
     Site            374..401
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:271122"
     CDS             1..527
                     /gene="bmpr1a.L"
                     /gene_synonym="acvrlk3; alk-3; alk3; cd292; skr5"
                     /coded_by="NM_001087738.1:367..1950"
                     /db_xref="GeneID:397711"
                     /db_xref="Xenbase:XB-GENE-17332218"
ORIGIN      
        1 mrerlfiacf galllvihtq gqdfnilphr tgmksnsdpk kqengvtlap edtlpflncy
       61 csgycpqnav nntcitngqc famieeddhg diiltsgcmk megsdfqckd spkalsrrti
      121 eccrtdfcnr dleptlspki sdgeyglrfi aliislvvcl ilivgfilii wiykhklhsq
      181 rmlynrnldp ddafipages lkalidisqs sgsgsglpll vqrtiakqiq mvrqigkgry
      241 gevwmgkwrg ekvavkvfft aeeaswfret eiyqtvlmrh enilgfiaad ikgtgswtqm
      301 yliteyheng slydflkctt ldtrsllkla ysaacglchl hteiygtqgk paiahrdlks
      361 knilikenwt cciadlglav kfnsdthevd iplntrvgtk rymapevlde slnknhfqay
      421 imadiysfsl iiwemtrrci tggiveeyql pyydmvpndp sfedmrevvc mkclrptvsn
      481 rwnsdeclra vlklmaecwa qnpasrltal rikktlakmv esqdvki
//