LOCUS       NP_001094537             404 aa            linear   MAM 18-DEC-2022
DEFINITION  ubiquitin-like modifier-activating enzyme 5 [Bos taurus].
ACCESSION   NP_001094537 XP_586224
VERSION     NP_001094537.1
DBSOURCE    REFSEQ: accession NM_001101067.2
KEYWORDS    RefSeq.
SOURCE      Bos taurus (cattle)
  ORGANISM  Bos taurus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
REFERENCE   1  (residues 1 to 404)
  AUTHORS   Duan R, Shi Y, Yu L, Zhang G, Li J, Lin Y, Guo J, Wang J, Shen L,
            Jiang H, Wang G and Tang B.
  TITLE     UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar
            Ataxia
  JOURNAL   PLoS One 11 (2), e0149039 (2016)
   PUBMED   26872069
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 404)
  AUTHORS   Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D,
            Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G,
            Roberts M, Subramanian P, Yorke JA and Salzberg SL.
  TITLE     A whole-genome assembly of the domestic cow, Bos taurus
  JOURNAL   Genome Biol 10 (4), R42 (2009)
   PUBMED   19393038
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC151254.1.
            
            On Aug 14, 2007 this sequence version replaced XP_586224.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC151254.1, SRR5571263.44533.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN03145412, SAMN03145413
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..404
                     /organism="Bos taurus"
                     /db_xref="taxon:9913"
                     /chromosome="1"
                     /map="1"
                     /breed="Hereford"
     Protein         1..404
                     /product="ubiquitin-like modifier-activating enzyme 5"
                     /note="UFM1-activating enzyme; ubiquitin-activating enzyme
                     5; ubiquitin-activating enzyme E1 domain-containing
                     protein 1"
                     /calculated_mol_wt=44566
     Site            45
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZZ9; propagated from
                     UniProtKB/Swiss-Prot (A7MAZ3.1)"
     Region          52..297
                     /region_name="ThiF_MoeB_HesA_family"
                     /note="ThiF_MoeB_HesA. Family of E1-like enzymes involved
                     in molybdopterin and thiamine biosynthesis family. The
                     common reaction mechanism catalyzed by MoeB and ThiF, like
                     other E1 enzymes, begins with a nucleophilic attack of the
                     C-terminal carboxylate of MoaD...; cd00757"
                     /db_xref="CDD:238386"
     Site            order(80,82,84,104,106,115,127,181,187)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:238386"
     Site            order(84,182..184,188,206..207,213,215,282,286,293,
                     295..296)
                     /site_type="other"
                     /note="substrate interface [chemical binding]"
                     /db_xref="CDD:238386"
     Region          334..346
                     /region_name="UFM1-interacting sequence (UIS).
                     /evidence=ECO:0000250|UniProtKB:Q9GZZ9"
                     /note="propagated from UniProtKB/Swiss-Prot (A7MAZ3.1)"
     Site            358
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZZ9; propagated from
                     UniProtKB/Swiss-Prot (A7MAZ3.1)"
     Site            393
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8VE47; propagated from
                     UniProtKB/Swiss-Prot (A7MAZ3.1)"
     CDS             1..404
                     /gene="UBA5"
                     /coded_by="NM_001101067.2:194..1408"
                     /db_xref="BGD:BT24476"
                     /db_xref="GeneID:509292"
                     /db_xref="VGNC:VGNC:36564"
ORIGIN      
        1 maesverlqq rveelerela qersrralgs gdggggrari ekmssevvds npysrlmalk
       61 rmgivsdyek irtftvaivg vggvgsvtae mltrcgigkl llfdydkvel anmnrlffqp
      121 hqaglskvqa aehtlrninp dvlfevhnyn ittvenfehf mnrisnggle egkpvdlvls
      181 cvdnfearmt intacnelgq twmesgvsen avsghiqlii pgesacfaca pplvvaanid
      241 ektlkregvc aaslpttmgv vagilvqnvl kfllnfgtvs fylgynamqd ffptmsmkpn
      301 pqcddrncrk qqkeykkkva alpkqeviqe egeiihedne wgielvseis eeelkkssgp
      361 ipdlpegiiv aytvpqkqed svpevtveds gesledlmak mkni
//