LOCUS       NP_001103000             325 aa            linear   ROD 21-MAR-2023
DEFINITION  SAM pointed domain-containing Ets transcription factor [Rattus
            norvegicus].
ACCESSION   NP_001103000 XP_001069981 XP_006256291
VERSION     NP_001103000.1
DBSOURCE    REFSEQ: accession NM_001109530.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 325)
  AUTHORS   Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P,
            Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM,
            Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E,
            Kivioja T and Taipale J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   2  (residues 1 to 325)
  AUTHORS   Ghadersohi A, Sharma S, Zhang S, Azrak RG, Wilding GE, Manjili MH
            and Li F.
  TITLE     Prostate-derived Ets transcription factor (PDEF) is a potential
            prognostic marker in patients with prostate cancer
  JOURNAL   Prostate 71 (11), 1178-1188 (2011)
   PUBMED   21656828
REFERENCE   3  (residues 1 to 325)
  AUTHORS   Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y,
            Gregorieff A, Clevers H and Whitsett JA.
  TITLE     SPDEF is required for mouse pulmonary goblet cell differentiation
            and regulates a network of genes associated with mucus production
  JOURNAL   J Clin Invest 119 (10), 2914-2924 (2009)
   PUBMED   19759516
REFERENCE   4  (residues 1 to 325)
  AUTHORS   Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M,
            Korving J, Peters PJ and Clevers H.
  TITLE     The ets-domain transcription factor Spdef promotes maturation of
            goblet and paneth cells in the intestinal epithelium
  JOURNAL   Gastroenterology 137 (4), 1333-45 (2009)
   PUBMED   19549527
REFERENCE   5  (residues 1 to 325)
  AUTHORS   Ghadersohi A, Odunsi K, Zhang S, Azrak RG, Bundy BN, Manjili MH and
            Li F.
  TITLE     Prostate-derived Ets transcription factor as a favorable prognostic
            marker in ovarian cancer patients
  JOURNAL   Int J Cancer 123 (6), 1376-1384 (2008)
   PUBMED   18567002
REFERENCE   6  (residues 1 to 325)
  AUTHORS   Park KS, Korfhagen TR, Bruno MD, Kitzmiller JA, Wan H, Wert SE,
            Khurana Hershey GK, Chen G and Whitsett JA.
  TITLE     SPDEF regulates goblet cell hyperplasia in the airway epithelium
  JOURNAL   J Clin Invest 117 (4), 978-988 (2007)
   PUBMED   17347682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000324.1.
            
            On or before Apr 8, 2021 this sequence version replaced
            XP_006256291.1, XP_001069981.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..325
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..325
                     /product="SAM pointed domain-containing Ets transcription
                     factor"
                     /calculated_mol_wt=36206
     Region          124..204
                     /region_name="SAM_PNT-PDEF-like"
                     /note="Sterile alpha motif (SAM)/Pointed domain of
                     prostate-derived ETS factor; cd08532"
                     /db_xref="CDD:188878"
     Region          238..324
                     /region_name="ETS"
                     /note="erythroblast transformation specific domain;
                     smart00413"
                     /db_xref="CDD:197710"
     CDS             1..325
                     /gene="Spdef"
                     /coded_by="NM_001109530.2:371..1348"
                     /db_xref="GeneID:689210"
                     /db_xref="RGD:1594842"
ORIGIN      
        1 mgsaspglsn vspgclllsp dvalrtgvek aasgamglek qewspsppat peqglsafyl
       61 syfnmypedg swvakvpeas aredhpeepe qcpvidsqas gntldehsle qvqsmvvgev
      121 lkdietackl lnitadpgdw spgnvqkwll wtehqyrlpp agkafqelgg kelcamseeq
      181 frqraplggd vlhahldiwk saawmkerts pgalhycast seegwtdgev dsscsgqpih
      241 lwqflkelll kphsygrfir wlnkekgifk iedsaqvarl wgvrknrpam nydklsrsir
      301 qyykkgiirk pdisqrlvyq fvhpv
//