LOCUS NP_001107242 798 aa linear MAM 30-JUN-2023
DEFINITION integrin beta-1 precursor [Ovis aries].
ACCESSION NP_001107242
VERSION NP_001107242.1
DBSOURCE REFSEQ: accession NM_001113770.1
KEYWORDS RefSeq.
SOURCE Ovis aries (sheep)
ORGANISM Ovis aries
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
REFERENCE 1 (residues 1 to 798)
AUTHORS Ghasemzadeh-Hasankolaei M, Eslaminejad MB, Batavani R and
Sedighi-Gilani M.
TITLE Comparison of the efficacy of three concentrations of retinoic acid
for transdifferentiation induction in sheep marrow-derived
mesenchymal stem cells into male germ cells
JOURNAL Andrologia 46 (1), 24-35 (2014)
PUBMED 23131047
REFERENCE 2 (residues 1 to 798)
AUTHORS He X, Li B, Wang F, Tian C, Rong W and Liu Y.
TITLE Identification of differentially expressed genes in Mongolian sheep
ovaries by suppression subtractive hybridization
JOURNAL Anim Reprod Sci 133 (1-2), 86-92 (2012)
PUBMED 22727452
REMARK GeneRIF: Four differentially expressed genes,ADAMTS1,ID3,
BMP6,ITGB1, were randomly selected and verified using relative
quantitative real-time polymerase chain reaction.
REFERENCE 3 (residues 1 to 798)
AUTHORS Du J, Chang H, Gao S, Cong G, Shao J, Lin T, Liu Z, Liu X and Cai
X.
TITLE Sheep (Ovis aries) integrins alphavbeta1 and alphavbeta6 related to
foot-and-mouth disease virus infection: molecular cloning, sequence
analysis and comparison with homologues
JOURNAL Mol Cell Probes 23 (5), 247-257 (2009)
PUBMED 19555755
REMARK GeneRIF: Sheep alphav, beta1, and beta6 integrin cDNAs were cloned
and compared to those of other species.
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from EU367988.1.
##Evidence-Data-START##
Transcript exon combination :: EU367988.1, SRR11036013.209120.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA103992853, SAMEA103992854
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..798
/organism="Ovis aries"
/db_xref="taxon:9940"
/chromosome="13"
/map="13"
Protein 1..798
/product="integrin beta-1 precursor"
/note="Integrin subunit beta-1; Integrin VLA-4 subunit
beta; integrin, beta 1 (fibronectin receptor, beta
polypeptide, antigen CD29 includes MDF2, MSK12);
fibronectin receptor subunit beta; integrin beta-1"
/calculated_mol_wt=85686
sig_peptide 1..22
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2443
Region 34..464
/region_name="INB"
/note="Integrin beta subunits (N-terminal portion of
extracellular region); smart00187"
/db_xref="CDD:197563"
Site 50
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Region 75..105
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 94
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 97
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Region 207..213
/region_name="CX3CL1-binding.
/evidence=ECO:0000250|UniProtKB:P05556"
/note="propagated from UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 212
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 247..267
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (B0FYY4.1)"
Region 295..314
/region_name="CX3CL1-binding.
/evidence=ECO:0000250|UniProtKB:P05556"
/note="propagated from UniProtKB/Swiss-Prot (B0FYY4.1)"
Region 383..465
/region_name="Interaction with TMEM182.
/evidence=ECO:0000250|UniProtKB:P07228"
/note="propagated from UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 406
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 417
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Region 466..495
/region_name="I-EGF_1"
/note="Integrin beta epidermal growth factor like domain
1; pfam18372"
/db_xref="CDD:436446"
Site 481
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 520
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 584
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Region 640..727
/region_name="Integrin_B_tail"
/note="Integrin beta tail domain; pfam07965"
/db_xref="CDD:429757"
Site 669
/site_type="glycosylation"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Region 752..795
/region_name="Integrin_b_cyt"
/note="Integrin beta cytoplasmic domain; pfam08725"
/db_xref="CDD:430176"
Region 762..767
/region_name="Signal for sorting from recycling endosomes,
interaction with ACAP1. /evidence=ECO:0000250"
/note="propagated from UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 777
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P05556; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 783
/site_type="phosphorylation"
/note="Phosphotyrosine.
/evidence=ECO:0000250|UniProtKB:P05556; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Region 785..792
/region_name="Interaction with ITGB1BP1.
/evidence=ECO:0000250"
/note="propagated from UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 785
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:P05556; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 789
/site_type="phosphorylation"
/note="Phosphothreonine.
/evidence=ECO:0000250|UniProtKB:P05556; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
Site 794
/site_type="acetylation"
/note="N6-acetyllysine, alternate.
/evidence=ECO:0000250|UniProtKB:P05556; propagated from
UniProtKB/Swiss-Prot (B0FYY4.1)"
CDS 1..798
/gene="ITGB1"
/coded_by="NM_001113770.1:1..2397"
/db_xref="GeneID:443141"
ORIGIN
1 mnlqlifwig lissvccvfg qadenrclka nakscgeciq agpncgwctn stflqegmpt
61 sarcddleal kkkgchpndi enprgskdik knknvtnrsk gtaeklqped itqiqpqqlv
121 lqlrsgepqt ftlkfkraed ypidlyylmd lsysmkddle nvkslgtdlm nemrritsdf
181 rigfgsfvek tvmpyisttp aklrnpctne qnctspfsyk nvlsltdkge vfnelvgkqr
241 isgnldspeg gfdaimqvav cgsligwrnv trllvfstda gfhfagdgkl ggivlpndgq
301 chlendmytm shyydypsia hlvqklsenn iqtifavtee fqpvykelkn lipksavgtl
361 sansgnviql iidaynslss evilensklp egvtinyksy ckngvngtge ngrkcsnisi
421 gdevqfeisi tankcpnkns etikikplgf teeveiilqf icececqseg ipgspkchdg
481 ngtfecgacr cnegrvgrhc ecstdevnse dmdaycrken sseicsnnge cvcgqcvcrk
541 rdntneiysg kfcecdnfnc drsnglicgg ngvckcrvce cnpnytgsac dcsldttscm
601 avngqicngr gvcecgackc tdpkfqgptc emcqtclgvc aehkecvqcr afnkgekkdt
661 caqecshfni tkvenrdklp qpgqvdplsh ckekdvddcw fyftysvngn neatvhvvet
721 pecptgpdii pivagvvagi vligpallli wkllmiihdr refakfekek mnakwdtgen
781 piyksavttv vnpkyegk
//
