GenomeNet

Database: RefSeq
Entry: NP_001125344
LinkDB: NP_001125344
Original site: NP_001125344 
LOCUS       NP_001125344             917 aa            linear   PRI 20-JUN-2020
DEFINITION  hexokinase-1 [Pongo abelii].
ACCESSION   NP_001125344
VERSION     NP_001125344.1
DBSOURCE    REFSEQ: accession NM_001131872.1
KEYWORDS    RefSeq.
SOURCE      Pongo abelii (Sumatran orangutan)
  ORGANISM  Pongo abelii
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pongo.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CR858409.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR858409.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..917
                     /organism="Pongo abelii"
                     /db_xref="taxon:9601"
                     /chromosome="10"
                     /map="10"
     Protein         1..917
                     /product="hexokinase-1"
                     /EC_number="2.7.1.1"
                     /note="HK I; hexokinase type I"
                     /calculated_mol_wt=102232
     Region          1..10
                     /region_name="Mitochondrial-binding peptide (MBP).
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P19367; propagated from
                     UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          12..460
                     /region_name="PTZ00107"
                     /note="hexokinase; Provisional"
                     /db_xref="CDD:240270"
     Region          21..219
                     /region_name="Hexokinase_1"
                     /note="Hexokinase; pfam00349"
                     /db_xref="CDD:278764"
     Region          73..207
                     /region_name="Hexokinase small subdomain 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01084"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Site            order(84..87,89,91,209,229..232)
                     /site_type="other"
                     /note="nucleotide binding site [chemical binding]"
                     /db_xref="CDD:212657"
     Region          84..91
                     /region_name="Glucose-6-phosphate 1 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          172..173
                     /region_name="Substrate 1 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          208..447
                     /region_name="Hexokinase large subdomain 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01084"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          208..209
                     /region_name="Substrate 1 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          225..459
                     /region_name="Hexokinase_2"
                     /note="Hexokinase; pfam03727"
                     /db_xref="CDD:281689"
     Region          291..294
                     /region_name="Substrate 1 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Site            337
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P05708; propagated from
                     UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          413..415
                     /region_name="Glucose-6-phosphate 1 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          462..907
                     /region_name="PTZ00107"
                     /note="hexokinase; Provisional"
                     /db_xref="CDD:240270"
     Region          469..667
                     /region_name="Hexokinase_1"
                     /note="Hexokinase; pfam00349"
                     /db_xref="CDD:278764"
     Region          521..655
                     /region_name="Hexokinase small subdomain 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01084"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Site            order(532..535,537,539,657,677..680)
                     /site_type="other"
                     /note="nucleotide binding site [chemical binding]"
                     /db_xref="CDD:212657"
     Region          532..536
                     /region_name="Glucose-6-phosphate 2 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          603..604
                     /region_name="Substrate 2 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          620..621
                     /region_name="Substrate 2 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          656..895
                     /region_name="Hexokinase large subdomain 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01084"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          656..657
                     /region_name="Substrate 2 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          673..907
                     /region_name="Hexokinase_2"
                     /note="Hexokinase; pfam03727"
                     /db_xref="CDD:281689"
     Region          682..683
                     /region_name="Substrate 2 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     Region          861..863
                     /region_name="Glucose-6-phosphate 2 binding.
                     /evidence=ECO:0000250|UniProtKB:P19367"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RC71.1)"
     CDS             1..917
                     /gene="HK1"
                     /coded_by="NM_001131872.1:95..2848"
                     /db_xref="GeneID:100172246"
ORIGIN      
        1 miaaqllayy ftelkddqvk kidkylyamr lsdetlidim trfrkemkng lsrdfnptat
       61 vkmlptfvrs ipdgsekgdf ialdlggssf rilrvqvnhe knqnvhmese vydtpenivh
      121 gsgsqlfdhv aeclgdfmek rkikdkkspv gftfsfpcqq skideavlit wtkrfkasgv
      181 egadvvklln kaikkrgdyd anivavvndt vgtmmtcgyd dqhcevglii gtgtnacyme
      241 elrhidlveg degrmcinte wgafgddgsl edirtefdre idrgslnpgk qlfekmvsgm
      301 ylgelvrlil vkmakegllf egritpellt rgkfntsdvs aieknkeglh nakeiltrlg
      361 vepsdddcvs vqhvctivsf rsanlvaatl gailnrlrdn kgtprlrttv gvdgslykth
      421 pqysrrfhkt lrrlvpdsdv rfllsesgsg kgaamvtava yrlaeqhrqi eetlahfhlt
      481 kdmllevkkr mraemelglr kqthnnaavk mlpsfvrrtp dgtengdfla ldlggtnfrv
      541 llvkirsgkk rtvemhnkiy aipieimqgt geelfdhivs cisdfldymg ikgprmplgf
      601 tfsfpckqts ldagilitwt kgfkatdcvg ndvatllrda ikrreefdld vvavvndtvg
      661 tmmtcayeep tcevglivgt gsnacymeem knvemvegdq gqmcinmewg afgdngcldd
      721 irthydrlvd eyslnagkqr yekmisgmyl geivrnilid ftkkgflfrg qiseplktrg
      781 ifetkflsqi esdrlallqv railqqlgln stcddsilvk tvcgvvsrra aqlcgagmaa
      841 vvdkirenrg ldrlnvtvgv dgtlyklhph fsrimhqtvk elspkcnvsf llsedgsgkg
      901 aalitavgvr lrteass
//
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