GenomeNet

Database: RefSeq
Entry: NP_001131031
LinkDB: NP_001131031
Original site: NP_001131031 
LOCUS       NP_001131031             643 aa            linear   PRI 20-JUN-2020
DEFINITION  anaphase-promoting complex subunit 5 isoform b [Homo sapiens].
ACCESSION   NP_001131031
VERSION     NP_001131031.1
DBSOURCE    REFSEQ: accession NM_001137559.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 643)
  AUTHORS   Xu M, Liu X, Xu Y, Zhu S and Gao Y.
  TITLE     Coexpression of Axin and APC gene fragments inhibits colorectal
            cancer cell growth via regulation of the Wnt signaling pathway
  JOURNAL   Mol Med Rep 16 (4), 3783-3790 (2017)
   PUBMED   28731177
  REMARK    GeneRIF: coexpression of APC5 and Axin genes significantly
            downregulated Wnt signaling in human SW480 CRC cells and inhibited
            cell growth.
REFERENCE   2  (residues 1 to 643)
  AUTHORS   Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M and
            Pandolfi PP.
  TITLE     Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a
            phosphatase-independent manner
  JOURNAL   Cell 144 (2), 187-199 (2011)
   PUBMED   21241890
REFERENCE   3  (residues 1 to 643)
  AUTHORS   Tran K, Kamil JP, Coen DM and Spector DH.
  TITLE     Inactivation and disassembly of the anaphase-promoting complex
            during human cytomegalovirus infection is associated with
            degradation of the APC5 and APC4 subunits and does not require
            UL97-mediated phosphorylation of Cdh1
  JOURNAL   J. Virol. 84 (20), 10832-10843 (2010)
   PUBMED   20686030
  REMARK    GeneRIF: Inactivation and disassembly of the anaphase-promoting
            complex during human cytomegalovirus infection is associated with
            degradation of the APC5 and APC4 subunits and does not require
            UL97-mediated phosphorylation of Cdh1.
REFERENCE   4  (residues 1 to 643)
  AUTHORS   Wasch R, Robbins JA and Cross FR.
  TITLE     The emerging role of APC/CCdh1 in controlling differentiation,
            genomic stability and tumor suppression
  JOURNAL   Oncogene 29 (1), 1-10 (2010)
   PUBMED   19826416
  REMARK    GeneRIF: Studies indicate that APC/C(Cdh1) is required to maintain
            genomic stability.
            Review article
REFERENCE   5  (residues 1 to 643)
  AUTHORS   Jin L, Williamson A, Banerjee S, Philipp I and Rape M.
  TITLE     Mechanism of ubiquitin-chain formation by the human
            anaphase-promoting complex
  JOURNAL   Cell 133 (4), 653-665 (2008)
   PUBMED   18485873
REFERENCE   6  (residues 1 to 643)
  AUTHORS   Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J and
            Peters JM.
  TITLE     Mitotic regulation of the human anaphase-promoting complex by
            phosphorylation
  JOURNAL   EMBO J. 22 (24), 6598-6609 (2003)
   PUBMED   14657031
REFERENCE   7  (residues 1 to 643)
  AUTHORS   Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F and Peters
            JM.
  TITLE     TPR subunits of the anaphase-promoting complex mediate binding to
            the activator protein CDH1
  JOURNAL   Curr. Biol. 13 (17), 1459-1468 (2003)
   PUBMED   12956947
REFERENCE   8  (residues 1 to 643)
  AUTHORS   Autieri MV.
  TITLE     Expression of anaphase-promoting complex 5 in balloon
            angioplasty-injured rat carotid arteries and mitogen-stimulated
            human vascular smooth muscle cells
  JOURNAL   Biochem. Biophys. Res. Commun. 282 (3), 723-728 (2001)
   PUBMED   11401522
REFERENCE   9  (residues 1 to 643)
  AUTHORS   Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV,
            Schleiffer A, Nasmyth K, Mann M and Peters JM.
  TITLE     Characterization of the DOC1/APC10 subunit of the yeast and the
            human anaphase-promoting complex
  JOURNAL   J. Biol. Chem. 274 (20), 14500-14507 (1999)
   PUBMED   10318877
REFERENCE   10 (residues 1 to 643)
  AUTHORS   Yu H, Peters JM, King RW, Page AM, Hieter P and Kirschner MW.
  TITLE     Identification of a cullin homology region in a subunit of the
            anaphase-promoting complex
  JOURNAL   Science 279 (5354), 1219-1222 (1998)
   PUBMED   9469815
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK025614.1, AA349724.1 and
            BX381618.2.
            
            Summary: This gene encodes a tetratricopeptide repeat-containing
            component of the anaphase promoting complex/cyclosome (APC/C), a
            large E3 ubiquitin ligase that controls cell cycle progression by
            targeting a number of cell cycle regulators such as B-type cyclins
            for 26S proteasome-mediated degradation through ubiquitination. The
            encoded protein is required for the proper ubiquitination function
            of APC/C and for the interaction of APC/C with transcription
            coactivators. It also interacts with polyA binding protein and
            represses internal ribosome entry site-mediated translation.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. These differences cause translation initiation
            at a downstream AUG and result in a shorter protein (isoform b),
            compared to isoform a. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR and
            lacks an in-frame portion of the internal coding region, compared
            to variant 1. These differences cause translation initiation at a
            downstream AUG and result in a shorter isoform (b) compared to
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025614.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     Protein         1..643
                     /product="anaphase-promoting complex subunit 5 isoform b"
                     /note="cyclosome subunit 5"
                     /calculated_mol_wt=72395
     Region          <1..66
                     /region_name="Apc5_N"
                     /note="N-terminal domain of the anaphase-promoting complex
                     subunit Apc5 (or Anapc5); cd16270"
                     /db_xref="CDD:293878"
     Site            order(5..7,10,14,44,48..51,53..54)
                     /site_type="other"
                     /note="CDC23 interaction interface [polypeptide binding]"
                     /db_xref="CDD:293878"
     Site            order(35,38..39,42,45..46)
                     /site_type="other"
                     /note="APC subunit 15 interaction interface [polypeptide
                     binding]"
                     /db_xref="CDD:293878"
     Region          149..183
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276806"
     Region          155..255
                     /region_name="ANAPC5"
                     /note="Anaphase-promoting complex subunit 5; pfam12862"
                     /db_xref="CDD:315526"
     Region          201..234
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276806"
     CDS             1..643
                     /gene="ANAPC5"
                     /gene_synonym="APC5"
                     /coded_by="NM_001137559.1:198..2129"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS45000.1"
                     /db_xref="GeneID:51433"
                     /db_xref="HGNC:HGNC:15713"
                     /db_xref="MIM:606948"
ORIGIN      
        1 maegelkdme qffddlsdsf sgtepevhkt svvglflrhm ilaysklsfs qvfklytalq
       61 qyfqngekkt vedadmelts rdegerkmek eeldvsvree evscsgplsq kqaefflsqq
      121 asllkndetk altpaslqke lnnllkfnpd faeahylsyl nnlrvqdvfs sthsllhyfd
      181 rliltgaesk sngeegygrs lryaalnlaa lhcrfghyqq aelalqeair iaqesndhvc
      241 lqhclswlyv lgqkrsdsyv llehsvkkav hfglprafag ktanklmdal kdsdllhwkh
      301 slselidisi aqktaiwrly grstmalqqa qmllsmnsle avnagvqqnn tesfavalch
      361 laelhaeqgc faaasevlkh lkerfppnsq haqlwmlcdq kiqfdramnd gkyhladslv
      421 tgitalnsie gvyrkavvlq aqnqmseahk llqkllvhcq klkntemvis vllsvaelyw
      481 rsssptialp mllqalalsk eyrlqylase tvlnlafaql ilgipeqals llhmaiepil
      541 adgaildkgr amflvakcqv asaasydqpk kaealeaaie nlneaknyfa kvdckerird
      601 vvyfqarlyh tlgktqernr camlfrqlhq elpshgvpli nhl
//
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