LOCUS NP_001131031 643 aa linear PRI 20-JUN-2020
DEFINITION anaphase-promoting complex subunit 5 isoform b [Homo sapiens].
ACCESSION NP_001131031
VERSION NP_001131031.1
DBSOURCE REFSEQ: accession NM_001137559.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 643)
AUTHORS Xu M, Liu X, Xu Y, Zhu S and Gao Y.
TITLE Coexpression of Axin and APC gene fragments inhibits colorectal
cancer cell growth via regulation of the Wnt signaling pathway
JOURNAL Mol Med Rep 16 (4), 3783-3790 (2017)
PUBMED 28731177
REMARK GeneRIF: coexpression of APC5 and Axin genes significantly
downregulated Wnt signaling in human SW480 CRC cells and inhibited
cell growth.
REFERENCE 2 (residues 1 to 643)
AUTHORS Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M and
Pandolfi PP.
TITLE Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a
phosphatase-independent manner
JOURNAL Cell 144 (2), 187-199 (2011)
PUBMED 21241890
REFERENCE 3 (residues 1 to 643)
AUTHORS Tran K, Kamil JP, Coen DM and Spector DH.
TITLE Inactivation and disassembly of the anaphase-promoting complex
during human cytomegalovirus infection is associated with
degradation of the APC5 and APC4 subunits and does not require
UL97-mediated phosphorylation of Cdh1
JOURNAL J. Virol. 84 (20), 10832-10843 (2010)
PUBMED 20686030
REMARK GeneRIF: Inactivation and disassembly of the anaphase-promoting
complex during human cytomegalovirus infection is associated with
degradation of the APC5 and APC4 subunits and does not require
UL97-mediated phosphorylation of Cdh1.
REFERENCE 4 (residues 1 to 643)
AUTHORS Wasch R, Robbins JA and Cross FR.
TITLE The emerging role of APC/CCdh1 in controlling differentiation,
genomic stability and tumor suppression
JOURNAL Oncogene 29 (1), 1-10 (2010)
PUBMED 19826416
REMARK GeneRIF: Studies indicate that APC/C(Cdh1) is required to maintain
genomic stability.
Review article
REFERENCE 5 (residues 1 to 643)
AUTHORS Jin L, Williamson A, Banerjee S, Philipp I and Rape M.
TITLE Mechanism of ubiquitin-chain formation by the human
anaphase-promoting complex
JOURNAL Cell 133 (4), 653-665 (2008)
PUBMED 18485873
REFERENCE 6 (residues 1 to 643)
AUTHORS Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J and
Peters JM.
TITLE Mitotic regulation of the human anaphase-promoting complex by
phosphorylation
JOURNAL EMBO J. 22 (24), 6598-6609 (2003)
PUBMED 14657031
REFERENCE 7 (residues 1 to 643)
AUTHORS Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F and Peters
JM.
TITLE TPR subunits of the anaphase-promoting complex mediate binding to
the activator protein CDH1
JOURNAL Curr. Biol. 13 (17), 1459-1468 (2003)
PUBMED 12956947
REFERENCE 8 (residues 1 to 643)
AUTHORS Autieri MV.
TITLE Expression of anaphase-promoting complex 5 in balloon
angioplasty-injured rat carotid arteries and mitogen-stimulated
human vascular smooth muscle cells
JOURNAL Biochem. Biophys. Res. Commun. 282 (3), 723-728 (2001)
PUBMED 11401522
REFERENCE 9 (residues 1 to 643)
AUTHORS Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV,
Schleiffer A, Nasmyth K, Mann M and Peters JM.
TITLE Characterization of the DOC1/APC10 subunit of the yeast and the
human anaphase-promoting complex
JOURNAL J. Biol. Chem. 274 (20), 14500-14507 (1999)
PUBMED 10318877
REFERENCE 10 (residues 1 to 643)
AUTHORS Yu H, Peters JM, King RW, Page AM, Hieter P and Kirschner MW.
TITLE Identification of a cullin homology region in a subunit of the
anaphase-promoting complex
JOURNAL Science 279 (5354), 1219-1222 (1998)
PUBMED 9469815
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK025614.1, AA349724.1 and
BX381618.2.
Summary: This gene encodes a tetratricopeptide repeat-containing
component of the anaphase promoting complex/cyclosome (APC/C), a
large E3 ubiquitin ligase that controls cell cycle progression by
targeting a number of cell cycle regulators such as B-type cyclins
for 26S proteasome-mediated degradation through ubiquitination. The
encoded protein is required for the proper ubiquitination function
of APC/C and for the interaction of APC/C with transcription
coactivators. It also interacts with polyA binding protein and
represses internal ribosome entry site-mediated translation.
Multiple transcript variants encoding different isoforms have been
found for this gene. These differences cause translation initiation
at a downstream AUG and result in a shorter protein (isoform b),
compared to isoform a. [provided by RefSeq, Nov 2008].
Transcript Variant: This variant (2) contains a distinct 5' UTR and
lacks an in-frame portion of the internal coding region, compared
to variant 1. These differences cause translation initiation at a
downstream AUG and result in a shorter isoform (b) compared to
isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK025614.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
SAMEA1965299, SAMEA1966682
[ECO:0000350]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..643
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="12"
/map="12q24.31"
Protein 1..643
/product="anaphase-promoting complex subunit 5 isoform b"
/note="cyclosome subunit 5"
/calculated_mol_wt=72395
Region <1..66
/region_name="Apc5_N"
/note="N-terminal domain of the anaphase-promoting complex
subunit Apc5 (or Anapc5); cd16270"
/db_xref="CDD:293878"
Site order(5..7,10,14,44,48..51,53..54)
/site_type="other"
/note="CDC23 interaction interface [polypeptide binding]"
/db_xref="CDD:293878"
Site order(35,38..39,42,45..46)
/site_type="other"
/note="APC subunit 15 interaction interface [polypeptide
binding]"
/db_xref="CDD:293878"
Region 149..183
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276806"
Region 155..255
/region_name="ANAPC5"
/note="Anaphase-promoting complex subunit 5; pfam12862"
/db_xref="CDD:315526"
Region 201..234
/region_name="TPR repeat"
/note="TPR repeat [structural motif]"
/db_xref="CDD:276806"
CDS 1..643
/gene="ANAPC5"
/gene_synonym="APC5"
/coded_by="NM_001137559.1:198..2129"
/note="isoform b is encoded by transcript variant 2"
/db_xref="CCDS:CCDS45000.1"
/db_xref="GeneID:51433"
/db_xref="HGNC:HGNC:15713"
/db_xref="MIM:606948"
ORIGIN
1 maegelkdme qffddlsdsf sgtepevhkt svvglflrhm ilaysklsfs qvfklytalq
61 qyfqngekkt vedadmelts rdegerkmek eeldvsvree evscsgplsq kqaefflsqq
121 asllkndetk altpaslqke lnnllkfnpd faeahylsyl nnlrvqdvfs sthsllhyfd
181 rliltgaesk sngeegygrs lryaalnlaa lhcrfghyqq aelalqeair iaqesndhvc
241 lqhclswlyv lgqkrsdsyv llehsvkkav hfglprafag ktanklmdal kdsdllhwkh
301 slselidisi aqktaiwrly grstmalqqa qmllsmnsle avnagvqqnn tesfavalch
361 laelhaeqgc faaasevlkh lkerfppnsq haqlwmlcdq kiqfdramnd gkyhladslv
421 tgitalnsie gvyrkavvlq aqnqmseahk llqkllvhcq klkntemvis vllsvaelyw
481 rsssptialp mllqalalsk eyrlqylase tvlnlafaql ilgipeqals llhmaiepil
541 adgaildkgr amflvakcqv asaasydqpk kaealeaaie nlneaknyfa kvdckerird
601 vvyfqarlyh tlgktqernr camlfrqlhq elpshgvpli nhl
//
